<PAGE>
Pursuant to Rule 424(b)(3)
File No. 333-41442
SUPPLEMENT TO PROSPECTUS
DATED AUGUST 3, 2000
MAXIM PHARMACEUTICALS, INC.
October 6, 2000
------------------------
The Prospectus dated August 3, 2000, as declared effective on August 3,
2000, is hereby supplemented as follows to restate, in its entirety, the
"Selling Stockholders" section on pages 12-13 of the Prospectus.
<PAGE>
SELLING STOCKHOLDERS
We are registering for resale certain shares of our common stock held by the
selling stockholders identified below, including shares of our common stock
issuable upon the exercise of outstanding warrants. The following table sets
forth:
- the name of the selling stockholders;
- the number and percent of shares of our common stock that the selling
stockholders beneficially owned prior to the offering for resale of any of
the shares of our common stock being registered by the registration
statement of which this prospectus is a part;
- the number of shares of our common stock that may be offered for resale
for the account of the selling stockholders pursuant to this prospectus;
and
- the number and percent of shares of our common stock to be held by the
selling stockholders after the offering of the resale shares (assuming all
of the resale shares are sold by the selling stockholders).
This information is based upon information provided by selling stockholders,
schedules 13G and/or other public documents filed with the SEC, and assumes the
sale of all of the resale shares by the selling stockholders. The term "selling
stockholders" includes the stockholders listed below and their transferees,
pledgees, donees or other successors. The applicable percentages of ownership
are based on an aggregate of 22,687,736 shares of common stock issued and
outstanding as of June 16, 2000.
In connection with our acquisition of Cytovia, Inc., we agreed to register
common stock for those stockholders for resale. We are unable to determine the
exact number of shares that actually have been or will be sold.
<TABLE>
<CAPTION>
SHARES
SHARES BENEFICIALLY BENEFICIALLY
OWNED PRIOR TO OWNED AFTER
OFFERING NUMBER OF OFFERING
------------------- SHARES BEING --------------------
SELLING STOCKHOLDERS NUMBER PERCENT OFFERED NUMBER PERCENT
------------------------------------------------ -------- -------- ------------ -------- ---------
<S> <C> <C> <C> <C> <C>
SBIC Partners II, L.P........................... 308,991 1.36% 308,991 -- --
Crosspoint Venture Partners 1997................ 231,743 1.02% 231,743 -- --
Crosspoint Associates
1997 LLC(1)................................. 16,066 * 16,066 -- --
Shott Capital Management
SBC Master Pension Trust(1)................. 6,105 * 6,105 -- --
The William & Flora Hewlett Foundation(1)..... 6,105 * 6,105 -- --
Northern Trust Company as Trustee for Lucent
Technologies Inc. Master Pension Trust(1)... 5,612 * 5,612 -- --
Harvard Private Capital Holdings, Inc.(1)..... 5,233 * 5,233 -- --
Church Pension Fund(1)........................ 4,360 * 4,360 -- --
Massachusetts Institute of Technology(1)...... 4,360 * 4,360 -- --
Shott Capital Management for Wellcome
Trust(1).................................... 4,360 * 4,360 -- --
Yale University(1)............................ 4,360 * 4,360 -- --
Leeway & Co.(1)............................... 3,545 * 3,545 -- --
Milder Community Property Trust(1)............ 3,183 * 3,183 -- --
Rich Shapero(1)............................... 3,181 * 3,181 -- --
Robert Hoff(1)................................ 3,181 * 3,181 -- --
Seth D. Nelman & Lauren Speeth Trustees(1).... 3,181 * 3,181 -- --
Mellon Bank, N.A. as Trustee for the Bell
Atlantic Master Trust(1).................... 3,052 * 3,052 -- --
Shott Capital Management for University of
Chicago(1).................................. 2,616 * 2,616 -- --
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
SHARES
SHARES BENEFICIALLY BENEFICIALLY
OWNED PRIOR TO OWNED AFTER
OFFERING NUMBER OF OFFERING
------------------- SHARES BEING --------------------
SELLING STOCKHOLDERS NUMBER PERCENT OFFERED NUMBER PERCENT
------------------------------------------------ -------- -------- ------------ -------- ---------
<S> <C> <C> <C> <C> <C>
Rector and Visitors of the University of
Virginia(1)................................. 2,616 * 2,616 -- --
John B. and Christine J. Mumford Trust(1)..... 2,539 * 2,539 -- --
HarbourVest Partners V--Partnership Fund
LP(1)....................................... 2,243 * 2,243 -- --
M.C. Partners III LLC(1)...................... 1,308 * 1,308 -- --
Computrol Limited, BVI(1)..................... 872 * 872 -- --
Harvard Master Trust(1)....................... 872 * 872 -- --
Norwest Equity Capital, LLC(1)................ 872 * 872 -- --
Shott Capital Management for Walton Ventures,
LLC(1)...................................... 872 * 872 -- --
HarbourVest Partners V--Parallel Partnership
Fund LP(1).................................. 374 * 374 -- --
Barbara N. Lubash(1).......................... 161 * 161 -- --
Mumford Special Trust #1(1)................... 160 * 160 -- --
Mumford Special Trust #2(1)................... 160 * 160 -- --
Mumford Special Trust #3(1)................... 160 * 160 -- --
Mumford Special Trust #4(1)................... 160 * 160 -- --
George A. Needham(1).......................... 109 * 109 -- --
Okoboji Trust dated 6/19/85(1)................ 109 * 109 -- --
Dench Living Trust dated 6/16/94(1)........... 87 * 87 -- --
Safi U. Qureshey Family Trust(1).............. 87 * 87 -- --
Stradling, Yocca, Carlson & Rauth Investment
Partnership of 1982(1)...................... 65 * 65 -- --
Andre Touma(1)................................ 44 * 44 -- --
Andrew Alcon(1)............................... 44 * 44 -- --
Brody Family Trust U/D/T 8/15/86(1)........... 44 * 44 -- --
C. Preston Butcher & Carolyn F. Butcher TTEES
CPB/CFB Revocable Trust U/D/T dated
2/2/98(1)................................... 44 * 44 -- --
Howard S. Flagg(1)............................ 43 * 43 -- --
John B. Mumford & Christine J. Mumford Trust
U/D/T dated 10/13/83(1)..................... 43 * 43 -- --
Kenneth & Roberta Eldred Revocable Trust U/A
dated 1/28/83 Kenneth & Roberta Eldred
TTEES(1).................................... 43 * 43 -- --
Silicon Valley Bancshares(1).................. 43 * 43 -- --
Wallace R. Hawley Family Holdings, Ltd.(1).... 43 * 43 -- --
Alan and Terri Hoops Trust UTD 6/17/87(1)..... 22 * 22 -- --
Barbara A. Cannon(1).......................... 22 * 22 -- --
Bret W. Jorgenson Sep. Prop. Trust dtd
7/16/99(1).................................. 22 * 22 -- --
Craig T. & Penny L. Davenport Family
Trust(1).................................... 22 * 22 -- --
DIMA Ventures(1).............................. 22 * 22 -- --
Donald R. Myll(1)............................. 22 * 22 -- --
Gordon Clemons(1)............................. 22 * 22 -- --
Helmet Investments, LLC(1).................... 22 * 22 -- --
John F. Nicholson(1).......................... 22 * 22 -- --
Joseph P. Tallman(1).......................... 22 * 22 -- --
Kenneth Virnig(1)............................. 22 * 22 -- --
Kriens Revocable Trust dated 10/29/96(1)...... 22 * 22 -- --
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
SHARES
SHARES BENEFICIALLY BENEFICIALLY
OWNED PRIOR TO OWNED AFTER
OFFERING NUMBER OF OFFERING
------------------- SHARES BEING --------------------
SELLING STOCKHOLDERS NUMBER PERCENT OFFERED NUMBER PERCENT
------------------------------------------------ -------- -------- ------------ -------- ---------
<S> <C> <C> <C> <C> <C>
Living Trust of Stephens F. Millard dated
9/16/91(1).................................. 22 * 22 -- --
Louis E. Hallman, III & Sherry L. Messman
Family Trust(1)............................. 22 * 22 -- --
Lubock Family Trust dated 5/14/91(1).......... 22 * 22 -- --
Michael Grimes(1)............................. 22 * 22 -- --
Price Trust U/T/A dated 10/5/84 as amended
Thomas A. Price Trustee(1).................. 22 * 22 -- --
Robert & Betsy Rosenbluth Revocable Living
Trust Dated 4/11/91(1)...................... 22 * 22 -- --
Robert C. Hawk(1)............................. 22 * 22 -- --
Robert M. Fell(1)............................. 22 * 22 -- --
Sheldon D. Asher Trust Dated 8/31/98(1)....... 22 * 22 -- --
The Byrnes Family Trust Dated 7/24/86(1)...... 22 * 22 -- --
Barbara Reiter(1)............................. 13 * 13 -- --
Mary Ellen Ashburn(1)......................... 13 * 13 -- --
Steve Foster(1)............................... 13 * 13 -- --
John Selling(1)............................... 11 * 11 -- --
Lydia Selling(1).............................. 11 * 11 -- --
George Abe(1)................................. 9 * 9 -- --
Antoinette Belt(1)............................ 5 * 5 -- --
Christine Burkett(1).......................... 5 * 5 -- --
Mark A. Tonnesen(1)........................... 5 * 5 -- --
Robert D. Lent(1)............................. 5 * 5 -- --
Aneel Bhusrl(1)............................... 4 * 4 -- --
Bruce Edwards(1).............................. 4 * 4 -- --
David McCarty(1).............................. 4 * 4 -- --
Keith Krach--Ariba, Inc.(1)................... 4 * 4 -- --
Mark Floyd(1)................................. 4 * 4 -- --
Adam Dell--Impact Venture Partners(1)......... 3 * 3 -- --
Domain Partners IV, L.P......................... 157,627 * 157,627 -- --
Eckard Weber(2)................................. 138,175 * 135,798 2,377 *
Domain Partners III, L.P........................ 123,581 * 123,581 -- --
Aurora Biosciences Corporation.................. 98,959 * 98,959 -- --
Sanderling Venture Partners IV, L.P............. 97,547 * 97,547 -- --
3i BioScience Investment Trust PLC.............. 88,047 * 88,047 -- --
Axys Pharmaceuticals, Inc....................... 70,900 * 70,900 -- --
Sanderling IV Limited, L.P...................... 38,055 * 38,055 -- --
Sanderling IV Biomedical, L.P................... 37,974 * 37,974 -- --
Sanderling [Feri Trust] Venture Partners IV,
G.P........................................... 10,821 * 10,821 -- --
Jeff & Oriana Vick as Community Property(3)..... 21,893 * 10,654 11,239 *
Sanderling IV Biomedical Co-Investment Fund..... 10,628 * 10,628 -- --
Sanderling Venture Partners IV Co-Investment
Fund.......................................... 10,628 * 10,628 -- --
Marvin Rosenthale(4)............................ 6,658 6,658 -- --
F. Richard Nichol(5)............................ 5,193 * 5,193 -- --
DP III Associates, L.P.......................... 4,182 * 4,182 -- --
GC&H Investments................................ 4,087 * 4,087 -- --
Bernd Seizinger(6).............................. 4,041 * 4,041 -- --
Comdisco(7)..................................... 3,958 * 3,958 -- --
DP IV Associates, L.P........................... 3,776 * 3,776 -- --
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
SHARES
SHARES BENEFICIALLY BENEFICIALLY
OWNED PRIOR TO OWNED AFTER
OFFERING NUMBER OF OFFERING
------------------- SHARES BEING --------------------
SELLING STOCKHOLDERS NUMBER PERCENT OFFERED NUMBER PERCENT
------------------------------------------------ -------- -------- ------------ -------- ---------
<S> <C> <C> <C> <C> <C>
Fred A. Middleton............................... 2,640 * 2,640 -- --
Robert G. McNeil(8)............................. 2,640 * 2,640 -- --
Lowell E. Sears as Trustee of the Sears Living
Trust Dtd 3/11/91............................. 2,452 * 2,452 -- --
Ingrid Rothe(1)................................. 2,000 * 2,000 -- --
Marker Gene Technologies, Inc................... 761 * 761 -- --
Wu Yang......................................... 680 * 680 -- --
Linda Francis(9)................................ 190 * 190 -- --
Tye Waterhouse.................................. 139 * 139 -- --
Susan L. Gawlak................................. 110 * 110 -- --
Shaojuan Jia(10)................................ 67 * 67 -- --
</TABLE>
------------------------
* Less than 1%
(1) Represents number of shares acquired pursuant to a transfer or distribution
from another selling stockholder after June 16, 2000. With respect to such
selling stockholder, we are unable to determine the number of shares of our
common stock beneficially held by it other than the shares being offered by
this Prospectus.
(2) Includes 2,377 shares subject to stock options exercisable within 60 days
from June 16, 2000.
(3) Includes 11,239 shares subject to stock options exercisable within 60 days
from June 16, 2000.
(4) Includes 6,658 shares subject to stock options exercisable within 60 days
from June 16, 2000.
(5) Includes 4,375 shares subject to stock options exercisable within 60 days
from June 16, 2000.
(6) Includes 4,041 shares subject to stock options exercisable within 60 days
from June 16, 2000.
(7) Includes 3,958 shares subject to warrants exercisable within 60 days from
June 16, 2000.
(8) Includes 167 shares held by Robert G. McNeil, Trustee of the Sanderling
Management Company, LLC Retirement Trust FBO Robert G. McNeil.
(9) Includes 190 shares subject to stock options exercisable within 60 days from
June 16, 2000.
(10) Includes 67 shares subject to stock options exercisable within 60 days from
June 16, 2000.
