VULCAN VENTURES INC
SC 13D/A, 1999-10-21
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 _______________

                                 SCHEDULE 13D/A

                    Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*

                                 _______________

                                  VAXGEN, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    922390208
                                 (CUSIP Number)

 William D. Savoy                               Gail J. Gordon
 Vulcan Ventures Incorporated                   Foster Pepper & Shefelman PLLC
 110-110th Avenue N.E., Suite 550               1111 Third Avenue, Suite 3400
 Bellevue, WA  98004                            Seattle, WA  98101
 (206) 453-1940                                 (206) 447-4400

          (Name, Address and Telephone Number of Persons Authorized to
                      Receive Notices and Communications)

                                October 12, 1999
             (Date of Event which Requires Filing of This Statement)

                                 _______________

 If the filing person has previously  filed a statement on Schedule 13G to
 report the acquisition that is the subject of this Schedule 13D, and is filing
 this schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g),
 check the following box.  |_|

 Note: Schedules filed in paper format shall include a signed original and five
 copies of the schedule including all exhibits. See Sections 240.13d-7 for
 other parties to whom copies are to be sent.

 *The remainder of this cover page shall be filled out for a reporting person's
 initial filing on this form with respect to the subject class of securities,
 and for any subsequent amendment containing information which would alter
 disclosures provided in a prior cover page.

 The information required on the remainder of this cover page shall not be
 deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
 Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
 the Act but shall be subject to all other provisions of the Act(however, see
 the Notes).

<PAGE>

- ----------------------------             -------------------------------------
CUSIP NO.  922390208              13D     Page   2   of   9   Pages
- -----------------------------             -------------------------------------


- -------- ----------------------------------------------------------------------
   1     NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Vulcan Ventures Incorporated
- -------- ----------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*     (a) | |
                                                               (b) | |
- -------- ----------------------------------------------------------------------
   3     SEC USE ONLY


- -------- ----------------------------------------------------------------------
   4     SOURCE OF FUNDS*

                  WC
- -------- ----------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(E)                                       [_]

- -------- ----------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION

                  State of Washington
- -------- ----------------------------------------------------------------------
     NUMBER OF SHARES         7    SOLE VOTING POWER
  BENEFICIALLY OWNED BY                              -0- shares
           EACH
     REPORTING PERSON
           WITH
                            ------ --------------------------------------------
                              8    SHARED VOTING POWER
                                                     782,079 - shares  (1)

                            ------ --------------------------------------------
                              9    SOLE DISPOSITIVE POWER
                                                     -0- shares

                            ------ --------------------------------------------
                             10    SHARED DISPOSITIVE POWER
                                                     782,079 shares  (1)

- --------------------------- ------ --------------------------------------------
   11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                   782,079 shares  (1)
- --------- ---------------------------------------------------------------------
   12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)EXCLUDES CERTAIN SHARES*


- --------- ---------------------------------------------------------------------
   13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                   7.0%
- --------- ---------------------------------------------------------------------
   14     TYPE OF REPORTING PERSON*

                   CO
- --------- ---------------------------------------------------------------------
_______________
(1) Directly owned by Vulcan Ventures Incorporated. Paul G. Allen is the sole
shareholder of Vulcan Ventures Incorporated and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


- ---------------------------                ------------------------------------
CUSIP NO.   922390208              13D     Page   3   of   9   Pages
- ---------------------------                ------------------------------------


- --------- ---------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   Paul G. Allen
- --------- ---------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*     (a) |_|
                                                                (b) |_|

- --------- ---------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ---------------------------------------------------------------------
   4      SOURCE OF FUNDS*

                   AF
- --------- ---------------------------------------------------------------------
   5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
          ITEMS 2(d) OR 2(E)


- --------- ---------------------------------------------------------------------
   6      CITIZENSHIP OR PLACE OF ORGANIZATION

                   United States of America
- --------- ---------------------------------------------------------------------
  NUMBER OF SHARES BENEFICIALLY      7     SOLE VOTING POWER
            OWNED BY                                         -0- shares
              EACH
        REPORTING PERSON
              WITH
                                   ------- ------------------------------------
                                     8     SHARED VOTING POWER
                                                             782,079 shares (1)

                                   ------- ------------------------------------
                                     9     SOLE DISPOSITIVE POWER
                                                             -0- shares

                                   ------- ------------------------------------
                                     10    SHARED DISPOSITIVE POWER
                                                            782,079 shares  (1)

- ---------------------------------- ------- ------------------------------------
   11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                   782,079 shares  (1)
- --------- ---------------------------------------------------------------------
   12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)EXCLUDES CERTAIN SHARES*


- --------- ---------------------------------------------------------------------
   13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                   7.0%
- --------- ---------------------------------------------------------------------
   14     TYPE OF REPORTING PERSON*

                   IN
- --------- ---------------------------------------------------------------------
_______________
(1) Directly owned by Vulcan Ventures  Incorporated. Paul G. Allen is the sole
shareholder of Vulcan Ventures Incorporated and may be deemed to have shared
voting and dispositive power with respect to such shares.

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

Introductory Note

     The original statement on Schedule 13D to which this statement is filed as
Amendment No. 1 reported  that as of the filing date of the  Schedule 13D, the
reporting persons  beneficially  owned an  aggregate  of 871,158  shares of the
common stock,  $0.01 par value per share,  of VaxGen,  Inc. That number did not
account for a reverse 1-for-2 split effective  April 9, 1999, as to shares that
the reporting persons acquired in November 1998. The aggregate number of shares
that the reporting persons  beneficially owned as of the date on which the
Schedule 13D was filed was 739,579 shares representing approximately 6.9% of
the shares of common stock then outstanding. This Amendment No. 1 also reflects
subsequent open-market  purchases  by the reporting  persons and the  proposed
purchase of additional shares from the issuer in a private transaction.

Item 1.  Security and Issuer

         This statement relates to the common stock, $0.01 par value per share,
of VaxGen, Inc., a Delaware corporation (the "Issuer"). The Issuer's  principal
executive  offices are located at 1000 Marina  Boulevard, Suite 200,  Brisbane,
California 94005. Amounts stated in this statement reflect a one-for-two
reverse split of the number of shares of common stock issued and outstanding
effective April 9, 1999.

Item 2.  Identity and Background

         The persons filing this statement are Vulcan Ventures Incorporated
("Vulcan Ventures") and Paul G. Allen. Vulcan Ventures is a Washington
corporation whose principal business is investing in various companies.
Paul G. Allen is its sole shareholder.  The principal office of Vulcan Ventures
is located at 110-110th Avenue N.E., Suite 550, Bellevue, Washington 98004. All
of Vulcan Ventures' executive officers and directors are U.S. citizens.  Their
names, business addresses and principal occupations are as follows:

              Paul G. Allen, Vulcan  Ventures Incorporated, 110 - 110th Avenue
         N.E., Suite 550, Bellevue, Washington  98004. Mr. Allen is Chairman,
         President and sole shareholder of Vulcan Ventures and a Director and
         sole shareholder of Vulcan Northwest Inc.

              William D. Savoy, Vulcan Northwest Inc., 110-110th Avenue N.E.,
         Suite 550, Bellevue, Washington 98004. Mr. Savoy is Vice President and
         a Director of Vulcan Ventures and Chairman and President of Vulcan
         Northwest Inc.

              Bert E. Kolde, Vulcan Ventures Incorporated, 110 - 110th Avenue
         N.E., Suite 550, Bellevue, Washington 98004. Mr. Kolde is a
         Vice President, Secretary, Treasurer and a Director of Vulcan Ventures
         and a Vice President of Vulcan  Northwest Inc.

              Jo Allen Patton, Vulcan Northwest Inc., 110 - 110th Avenue N.E.,
         Suite 550, Bellevue, Washington 98004. Ms. Patton is Vice Chairman and
         a Vice President of Vulcan Ventures and Vulcan Northwest Inc.

         During the last five years, Mr. Allen and Vulcan Ventures have not,
nor, to the best knowledge of Vulcan Ventures, has any other person named in
this Item 2, been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors) or been a party to a civil  proceeding of
a judicial or administrative body of competent jurisdiction as a result of
which he is or was subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
federal or state securities laws or finding any violation with respect to such
laws.

Item 3:  Source and Amount of Funds or Other Consideration

     Vulcan Ventures acquired  131,579 shares of the Issuer's common stock from
the Issuer in a private transaction  on  November  20,  1998.  Vulcan  Ventures
purchased  an  additional 600,000  shares  of the  common  stock at the  public
offering price of $13.00 per share in the Issuer's initial  public  offering on
June 29, 1999. Vulcan

                                  Page 4 of 9
<PAGE>

Ventures  subsequently purchased an  additional  50,500 shares on the Nasdaq
Stock Market as more fully described in Item 5. Vulcan Ventures funded the
common stock purchases described in this paragraph from its own working
capital.  None of the funds used to purchase such common stock consisted of
funds or other consideration borrowed or otherwise obtained for the purpose of
acquiring, holding, trading or voting the shares of common stock.

         As more fully described in item 6 below, on October 12, 1999,  Vulcan
Ventures  entered  into a  non-binding letter of intent  with the Issuer and on
October 15, 1999  entered  into a Common Stock Purchase  Agreement  (the "Stock
Purchase  Agreement")  with the  Issuer  to purchase  2,173,913  shares  of the
Issuer's  common stock at $11.50 per share, for an aggregate  purchase price of
$24,999,999.50.  Vulcan  Ventures  has placed the funds  necessary  to fund the
purchase  under the Stock Purchase Agreement in escrow  pending  closing of the
transaction.  The  source of the escrowed  funds was Vulcan  Ventures'  working
capital.  None of the escrowed  funds consists of funds or other  consideration
borrowed or otherwise obtained for the purpose of acquiring, holding, trading
or voting the common stock to be acquired pursuant to Stock Purchase Agreement.

Item 4.  Purpose of Transaction

         Vulcan Ventures and Mr. Allen have acquired the Issuer's common stock
for investment purposes. Their pending acquisition of common stock pursuant to
the Stock Purchase Agreement is for investment purposes as well. Vulcan
Ventures or Mr. Allen may purchase additional shares of common stock from time
to time, depending on various factors, including, without limitation, the price
of the common stock, stock market conditions and the business prospects of the
Issuer.  Vulcan Ventures and Mr. Allen may also determine to dispose of some or
all of their beneficial holdings of the Issuer's securities. They reserve the
right to increase or decrease their holdings on such terms and at such times as
they may decide, subject to contractual limitations as set forth in Item 6.

        Except as set forth in this Item 4 and as contemplated by the Stock
Purchase Agreement described in Item 6 below, Vulcan Ventures and Mr. Allen
have no present plan or proposal that relates to or would  result in (i) the
acquisition of additional  securities or the  disposition  of securities of the
Issuer by any person, (ii) an extraordinary  corporate  transaction,  such as a
merger, reorganization, liquidation, or sale or transfer of a material amount
of assets involving the Issuer or any of its subsidiaries, (iii) any change in
the Issuer's present Board of Directors or management, (iv) any material change
in the Issuer's present capitalization or dividend policy or any other material
change in the Issuer's  business or corporate  structure, (v) any change in the
Issuer's charter or by-laws or other actions that may impede the acquisition of
control of the Issuer by any person, (vi) any change  that would  result in the
Issuer's common stock becoming eligible for termination of its registration
pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934, as
amended, or to cease to be authorized to be quoted  in  Nasdaq, or (vii) any
similar action.

Item 5.  Interest in Securities of the Issuer

         Vulcan Ventures and Mr. Allen beneficially own  782,079  shares of the
Issuer's common stock.  These shares represent approximately 7.0% of the shares
of the class outstanding based upon 11,250,152 shares outstanding as of October
15, 1999 as reported to Vulcan  Ventures by the Issuer. Vulcan Ventures and Mr.
Allen  share  the  power to vote and to  direct  the vote of, and the  power to
dispose and to direct the disposition  of, all 782,079  shares. If and when the
Stock Purchase Agreement closes, Vulcan Ventures and Mr. Allen will share
voting and  dispositive  power  over  2,955,992  shares  of common stock
representing approximately 22.0% of the Issuer's outstanding common stock,
assuming that the Issuer issues no shares other than the shares issuable under
the Stock Purchase Agreement until after the closing.

         To the best  knowledge of Vulcan Ventures and Mr. Allen, none of the
other parties named in Item 2 owns any of the Issuer's common stock.

         Since the date of the Issuer's initial public offering on June 29,
1999, Vulcan Ventures has made the following open-market purchases of the
Issuer's common stock on the Nasdaq Stock Market:

                                  Page 5 of 9
<PAGE>

         July 12, 1999     -  8,000 shares at $17.75
         August 11, 1999   - 22,500 shares at $16.125
         August 12, 1999   - 20,000 shares at $15.5938

Except as set forth in Item 6 of this statement, Vulcan Ventures and Mr. Allen
have not,  nor, to the  knowledge of Vulcan Ventures has any of its  executive
officers,  directors or controlling  persons, effected any  transactions in the
Issuer's common stock during the past sixty days.

Item 6.  Contracts, Arrangements, Understandings or Relationships with
         Respect to Securities of the Issuer.

         Under a Registration Rights Agreement by and among the Issuer, Vulcan
Ventures and certain  other of the Issuer's stockholders  entered in connection
with the Issuer's 1998 common stock offering, the holders of 40% or more of the
registrable securities, including the shares of common stock acquired by Vulcan
Ventures in the Issuer's 1998 common stock offering, are entitled to demand
that the Issuer register their registrable securities under the Securities Act
of 1933, as amended. The Issuer is not required to effect more than two
registrations pursuant to such demand registration rights. The holders of the
registrable securities are entitled to require the Issuer to include their
registrable securities in future registration statements that the Issuer may
file. The Issuer is not required to effect more that three registrations
pursuant to such  piggyback registration rights. These registration rights are
subject to  various  conditions and limitations, including the right of the
underwriters of an offering to limit the number of registrable securities that
may be included in the  offering.  In addition, holders of all of these shares
are restricted from exercising their demand rights until one year has elapsed
from June 29, 1999, the effective date of the Issuer's initial public offering.
The Issuer generally is required to bear all of the expenses of these
registrations, except underwriting discounts and selling commissions.
Registration of any of the registrable securities held by security holders with
registration rights will result in such shares becoming freely tradable without
restriction under the Securities Act immediately upon the effectiveness of such
registration.

         Vulcan Ventures has agreed not to offer to sell, sell or otherwise
dispose of, directly or indirectly, any shares of common stock during the
period ending 180 days after June 29, 1999, the date of the prospectus in the
Issuer's initial public offering, without the consent of Prudential Securities
Incorporated on behalf of the underwriters.

         On October 12, 1999, Vulcan Ventures entered into a non-binding letter
of intent with the Issuer and on October  15, 1999 entered into a Common Stock
Purchase Agreement (the "Stock Purchase  Agreement") with the Issuer to
purchase 2,173,913 shares of the  Issuer's common stock at $11.50 per share,
for an aggregate  purchase price of $24,999,999.50. Closing of the transaction
is subject to certain conditions, including the expiration or termination of
the applicable waiting period (and any  extension) under the  Hart-Scott-Rodino
Antitrust  Improvements Act of 1976, as amended. Vulcan Ventures has placed the
purchase  price in escrow,  and the Issuer has placed in escrow an  irrevocable
letter of  instruction  to the Issuer's transfer  agent  directing the transfer
agent to issue  the  shares to  Vulcan Ventures.  The  purchase  price  will be
released  to the Issuer and the letter of instruction  will be  released to the
transfer  agent upon receipt by the escrow agent of joint  escrow  instructions
from Vulcan  Ventures and the Issuer confirming  that the conditions to closing
have been satisfied.

         Under the Stock Purchase Agreement, the Issuer has  granted  to Vulcan
Ventures for one year following the closing of the transaction a right of first
refusal to purchase its pro rata share of "New  Securities."  "New  Securities"
means any of the Issuer's common stock issued in exchange for cash in a private
placement  transaction other than (i)  securities  issuable  upon  exercise  of
existing rights to acquire common stock issued to consultants or vendors of the
Issuer, or (ii) any other  issuances of 268,481 shares of common stock or less,
or securities of the Issuer exercisable for or convertible  into 268,481 shares
of common stock or less.

         Under a Registration Rights Agreement into which the Issuer and Vulcan
Ventures entered as of October 1, 1999, Vulcan Ventures and certain related
parties to whom it may transfer shares of the common stock that it has agreed
to purchase under the Stock Purchase Agreement are entitled to demand one
registration of such shares under the Securities Act. The Issuer must receive a
written request from the holders of at least 80% of such shares outstanding.
These registration rights are subject to various conditions and limitations,
including the

                                  Page 6 of 9
<PAGE>

right of the underwriters  in an  underwritten  offering to limit the number of
registrable securities  that  may be  included  in  the  offering.  The  Issuer
generally is required to bear all of the expenses of these registrations,
except underwriting discounts and selling  commissions. Registration  of any of
the registrable securities held by security holders with registration rights
will result in such shares becoming freely tradable without restriction under
the Securities Act immediately upon the effectiveness of such registration.

         The reporting persons will file an amendment to this statement along
with required exhibits if and after the closing of the transaction contemplated
by the Stock Purchase Agreement.

         Except as set forth in Item 4 of this statement and this Item 6,
Vulcan Ventures and Mr. Allen do not have, nor, to the knowledge of
Vulcan Ventures does any of the executive officers, directors or controlling
persons of Vulcan Ventures have, any contracts, arrangements, understandings or
relationships (legal or otherwise) with any person with respect to any
securities of the Issuer, finder's fees, joint ventures, loan or option
agreements, puts or calls, guarantees of profits, division of profits or loss,
or the giving or withholding of proxies.

Item 7.  Material To Be Filed as Exhibits.

        Exhibit   Description

          99.1    Joint Filing Agreement(Previously filed as Exhibit 1 to
                  the Schedule 13D.)

          99.2    Form of Lock-up Agreement (Previously filed as Exhibit 2
                  to the Schedule 13D.)

          99.3    Power of Attorney (Incorporated by reference to the Reporting
                  Persons' Schedule 13G for Pathogenesis Corporation filed
                  August 30, 1999.)


                                  Page 7 of 9
<PAGE>

                                   SIGNATURES

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

                                      VULCAN VENTURES INCORPORATED



         October 20, 1999             By:/s/ William D. Savoy
(Date)                                   William D. Savoy, Vice President


         October 20, 1999                       *
(Date)                                   Paul G. Allen


                                      *By:     /s/ William D. Savoy
                                             William D. Savoy, Attorney-in-Fact



                                  Page 8 of 9

<PAGE>

                                 EXHIBIT INDEX


        Exhibit   Description

         99.1     Joint Filing Agreement (Previously filed as Exhibit 1 to
                  the Schedule 13D.)

         99.2     Form of Lock-up Agreement (Previously filed as Exhibit 2
                  to the Schedule 13D.)

         99.3     Power of Attorney (Incorporated by reference to the Reporting
                  Persons' Schedule 13G for Pathogenesis Corporation filed
                  August 30, 1999.)

Page 9 of 9
<PAGE>


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