POLYNOUS TRUST
497, 2000-01-06
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[Letterhead of PFPC Inc.
3200 Horizon Drive
P.O. Box 61503
King of Prussia, PA  19406-0903]

January 6, 2000

VIA EDGAR

Securities and Exchange Commission
Judiciary Plaza
Public Filing Desk
450 Fifth Street, NW
Washington, DC  20549

Re:	Polynous Trust (the "Trust")
File Nos.  333-04983 and 811-07649
Rule 497(j) Filing

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, on behalf
of the Trust, please accept this letter as confirmation that the Prospectus
and Statement of Additional Information for the Trust do not differ from those
contained in Post-Effective Amendment No. 4/6 (the "Amendment") to the Trust's
registration statement on Form N-1A.  This Amendment was filed electronically
on December 30, 1999.

Please call the undersigned at (610) 239-4727 with any questions you may have.

Very truly yours,

/s/ Thomas N. Calabria

Thomas N. Calabria
Compliance Administrator



cc:	Kevin Wenck, Polynous Capital Management, Inc.
Mitch Nichter, Esq., Paul, Hastings, Janofsky & Walker LLP




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