AVAX TECHNOLOGIES INC
8-K, 1999-12-16
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                           ---------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                      December 16, 1999 (November 26, 1999)
                Date of Report (Date of earliest event reported)

                             AVAX TECHNOLOGIES, INC.
             (Exact name of Registrant as specified in its charter)

           Delaware                   000-29222                  13-3575874
 (State or other jurisdiction   (Commission File Number)       (IRS Employer
       of incorporation)                                  Identification Number)

                                4520 Main Street
                                    Suite 930
                              Kansas City, MO 64111
                    (Address of principal executive offices)

                                 (816) 960-1333
              (Registrant's telephone number, including area code)


<PAGE>

Item 5. Other Events

      (a) Long-term Follow-up Data of Patients Treated with M-Vax(TM).

      On November 26, 1999, the Company's Executive Vice President presented
nine-year follow-up data of stage III melanoma patients from Company-sponsored
Phase 2 studies of M-Vax, an immunotherapy designed for the treatment of
melanoma and the Company's lead development product, at the 26th Annual
Scientific Meeting of the Clinical Oncological Society of Australia in
Melbourne. The data was obtained from an ongoing study of a group of 71 patients
with advanced skin cancer who were cancer-free two years following treatment
with M-Vax, and then monitored for up to 9.8 years. The median follow-up time as
of November, 1999 was 5.3 years.

      David Berd, M.D., Professor of Medicine at Thomas Jefferson University,
and the inventor of M-Vax, began studies of M-Vax in 1989. At the time M-Vax was
administered, 39 of the 71 patients were deemed to have little chance of
long-term survival because their cancer had spread to one or more lymph nodes.
Of those 71 patients, 49 survived 5 years or more. Moreover, the overall
survival rate for the 6 patients that have been monitored for more than 9 years,
is approximately 85% (5 of 6 had survived). No serious or long-term toxic
effects of M-Vax were observed in any of these patients.

      In addition, the data have confirmed earlier findings by showing that a
patient's clinical outcome was strongly influenced by the development of a
positive immune response to the patient's own tumor cells, as measured by a
delayed type hypersensitivity test. A delayed type hypersensitivity test
measures the activity of T-lymphocytes, which are cells that are crucial in
triggering the body's immune system.

      (b) Australian Joint Venture.

      On November 25, 1999, the Company executed a definitive joint venture
agreement with Neptunus International Holdings Limited ("NIHL") in Australia,
under the subsidiary name, AVAX Holdings Australia Pty Limited ("AVAX
Holdings"). Pursuant to the joint venture agreement, AVAX Holdings, through its
affiliated entities, will manufacture and market M-Vax in Australia, and has
similar rights in New Zealand.

      As part of the agreement, NIHL paid $3,600,000 (AUD), and will pay an
additional $400,000 (AUD) by December 25, 1999 , for the purchase of a 20%
interest in the joint venture entities. NIHL also has the option to purchase an
additional 30% interest in the joint venture entities for $6,000,000 (AUD).
Under the terms of the agreement, the Company has been granted options to
purchase common stock equivalent to 5% of NIHL's fully diluted shares.

      On June 15, 1999, the Company announced that it had entered into a letter
agreement with NIHL, and that subject only to licensure of a manufacturing
facility by Australia's Therapeutic Goods Administration, the Company would
begin to market M-Vax in Australia. The Company is currently in the final stages
of choosing a location for its clean-room facility, which will be the
manufacturing and distribution center for M-Vax in Australia. The Company
expects to begin the build-out of this facility by January, 2000.


                                       2
<PAGE>

Item 7. Financial Statements and Exhibits.

      Exhibits.

      10.1  Shareholders Agreement dated November 25, 1999, among AVAX Australia
            Holdings Pty Limited, Eastpac Inc., Jetona Pty Ltd and Neptunus
            International Holdings Limited

                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                   AVAX TECHNOLOGIES, INC.

Date: December 16, 1999

                                   By: /s/ Jeffrey M. Jonas
                                      --------------------------
                                   Name:  Jeffrey M. Jonas, M.D.
                                   Title: President and Chief Executive Officer


                                       3
<PAGE>

                                Exhibit Index

Exhibit Number                            Description
- --------------                            -----------

    10.1                        Shareholders Agreement dated November 25, 1999.


                                       4

                                                                   Exhibit 10.1

                            Shareholders Agreement

                            Date:  25 November 1999

                       AVAX Australia Holdings Pty Limited

                                  AVAX Holdings

                                  Eastpac Inc.

                                    NIHL Sub

                                 Jetona Pty Ltd

                                 NIHL ServiceCo

                     Neptunus International Holdings Limited

                                      NIHL

                    [GRAPHIC OMITTED] Copyright Clayton Utz


                                                                               1

Liability is limited by the Solicitors Scheme under the Professional Standards
                                  Act 1994 NSW
<PAGE>


                                TABLE OF CONTENTS

Clause                                                                    Page

1.  DEFINITIONS AND INTERPRETATION                                           1

2.  THE COMPANIES                                                            7

3.  BUSINESS OF THE COMPANIES                                                9

4.  CONTRIBUTION OF WORKING CAPITAL AND OWNERSHIP OF THE COMPANIES          10

5.  DIRECTORS OF THE COMPANIES                                              12

6.  CHAIRMAN OF THE BOARD                                                   15

7.  MANAGEMENT OF THE COMPANIES                                             15

8.  TRANSACTION AGREEMENTS                                                  18

9.  NIHL OPTIONS                                                            18

10.   CONFIDENTIALITY                                                       18

11.   CONFIDENTIALITY OF COMMERCIAL CONTACTS                                20

12.   NO COMPETITION WITH THE COMPANIES                                     21

13.   FINANCIAL REPORTS AND DIVIDEND AND BORROWING POLICIES                 23

14.   CHANGE OF CONTROL, DEFAULT AND LIQUIDATION                            26

15.   ELECTION NOT TO CONTRIBUTE WORKING CAPITAL                            31

16.   PRE-EMPTION RIGHTS WHERE BONA FIDE OFFER                              32

17.   STATEMENT ON SHARE CERTIFICATES                                       35

18.   FURTHER JOINT VENTURES                                                35

                                                                               1
<PAGE>
                                TABLE OF CONTENTS

Clause                                                                    Page

19.   FURTHER AVAX LICENCES                                                 36

20.   PUBLICITY                                                             38

21.   GUARANTEE AND INDEMNITY                                               39

22.   TERM                                                                  42

23.   NOTICES                                                               42

24.   GOVERNING LAW AND JURISDICTION                                        45

25.   ARBITRATION                                                           45

26.   MISCELLANEOUS                                                         46

                                                                               2
<PAGE>

SHAREHOLDERS AGREEMENT dated 25 November 1999

BETWEEN          AVAX AUSTRALIA HOLDINGS PTY LIMITED, ACN 089 164 090 of c/-
                 Clayton Utz, Level 31, 1 O'Connell Street, Sydney, New South
                 Wales, Australia ("AVAX Holdings")

AND              EASTPAC INC.,  of c/- Tengis  Limited,  11/F Tower 2, The
                 Gateway,  25-27 Canton Road, Kowloon, Hong Kong ("NIHL Sub")

AND              JETONA PTY LTD, ACN 089 914 152 of Level 8, 157-159 Walker
                 Street, North Sydney, New South Wales, Australia ("NIHL
                 ServiceCo")

AND              NEPTUNUS INTERNATIONAL HOLDINGS LIMITED, ARBN 065 824 302 of
                 Level 8, 157-159 Walker Street, North Sydney, New South Wales,
                 Australia ("NIHL")

RECITALS

A.    AVAX Holdings is the legal and beneficial owner of the whole of the issued
      capital of AVAX Australia and AVAX Manufacturing.

B.    The parties hereto have reached agreement on the manner in which those
      companies will be owned, controlled and funded by them and wish by this
      document to record their said agreement.

C.    NIHL ServiceCo will provide certain services to AVAX Australia and will
      receive a fee in relation thereto.

D.    NIHL Sub and NIHL ServiceCo are wholly owned subsidiaries of NIHL and, in
      consideration of AVAX Holdings entering into this Agreement, NIHL has
      agreed to guarantee to AVAX Holdings the due and punctual performance by
      NIHL Sub and NIHL ServiceCo of the Obligations and to indemnify AVAX
      Holdings in respect of any breach by NIHL Sub or NIHL ServiceCo of any of
      the Obligations.

THE PARTIES AGREE:

1.    DEFINITIONS AND INTERPRETATION

1.1   Definitions

      In this Agreement:


                                                                               1
<PAGE>

      ""A" Class Ordinary Shares" means the shares in the capital of the
      Companies referred to in clause 2.2(a).

      "Additional Shareholder" has the meaning given in clause 15.2(e).

      A reference to a person who is an "associate" of another person is a
      reference to a person who is an associate of that other person within the
      meaning of the Corporations Law.

      "AVAX Australia" means AVAX Australia Pty Limited, ACN 089 164 536.

      "AVAX Australia Licence and Distribution Agreement" means the agreement
      annexed to this agreement and marked "A".

      "AVAX Manufacturing" means AVAX Australia Manufacturing Pty Limited, ACN
      089 164 563.

      "AVAX Manufacturing Licence Agreement" means the agreement annexed to this
      agreement and marked "B".

      "AVAX Technologies" means AVAX Technologies, Inc., a company incorporated
      in Delaware, United States of America, and having its address at 4520 Main
      Street, Suite 930, Kansas City, Missouri 64111, United States of America.

      ""B" Class Ordinary Shares" means the shares in the capital of the
      Companies referred to in clause 2.2(b).

      "Business" means (in relation to AVAX Australia) the business described in
      clause 3.1(a) and means (in relation to AVAX Manufacturing) the business
      described in clause 3.1(b) and, where appropriate, will mean both of them.

      "Business Day" means any day (not being a Saturday or Sunday) on which
      banks are open for general banking business in Melbourne, Australia and
      Kansas City, Missouri, USA.

      ""C" Class Ordinary Shares" means the shares in the capital of the
      Companies referred to in clause 2.2(c).

      "Companies" means each of AVAX Australia and AVAX Manufacturing.

      "Confidential Information" means all the information relating to the
      Business, the Licensed Products, Proprietary Property, other products of
      AVAX Technologies and its affiliates, licensors, and licensees,
      information provided by the Originators and information derived from
      efforts to Develop the Licensed Products which is or has


                                                                               2
<PAGE>

      been disclosed by AVAX Holdings (or any of its representatives) to either
      of the Companies, NIHL, NIHL ServiceCo or NIHL Sub (or any of their
      representatives) (orally or in writing) but excludes the Excluded
      Information.

      "Constitution" means (in relation to AVAX Australia) the Constitution of
      AVAX Australia and means (in relation to AVAX Manufacturing) the
      Constitution of AVAX Manufacturing and "Constitutions" means each of them.

      "Contacts" means, in relation to the parties, any names, addresses,
      telephone or facsimile numbers of institutions, buyers, sellers,
      suppliers, investors, brokers, financiers or other parties involved or to
      be involved with the Business or who would be interested in using the
      Business.

      "Corporations Law" means the Corporations Law of Victoria and includes
      where applicable a separate reference to the Corporations Law of each
      State or Territory of Australia other than Victoria.

      "Develop" in relation to the Licensed Products means the conduct of
      research into the Licensed Products and the development of the Licensed
      Products.

      "Development Agreement" means the agreement annexed to this Agreement and
      marked "C".

      "Directors" means the directors of the Companies from time to time.

      A reference to a person "entitled to" shares in a company is a reference
      to a person entitled to those shares within the meaning of the
      Corporations Law.

      "Event of Default" has the meaning given in clause 14.2.

      "Excluded Information" means information and/or material and/or Contacts,
      other than Proprietary Property, which is, in relation to the recipient:

      (a)   at the time of supply or access to the recipient:

            (i)   already in or subsequently enters the public domain through no
                  fault, action or omission of the recipient; or

            (ii)  already lawfully known to the recipient; or

      (b)   subsequently received by the recipient without any breach by the
            recipient of its obligations to the Originator under this Agreement
            as will be documented by the written records of the recipient
            maintained in the ordinary course of business.


                                                                               3
<PAGE>

      The recipient will bear the burden of proving by clear and convincing
      evidence the existence of any of the exceptions provided in this
      definition of "Excluded Information" prior to any use or disclosure of
      Confidential Information other than as provided by this Agreement. If the
      recipient elects to rely on any such exception with respect to any
      Confidential Information, then, prior to any use or disclosure of
      Confidential Information other than as provided by this Agreement, the
      recipient will notify the disclosing party in writing of its intent to so
      use or disclose, which will include:

      (a)   an identification of the specific Confidential Information and
            exception to be relied on;

      (b)   the basis for the recipient's reliance on such exception with
            respect to such Confidential Information; and

      (c)   the nature of the intended use or disclosure.

      In the event that the disclosing party fails to advise the recipient in
      writing within forty-five (45) calendar days after its receipt of such
      notice that, in its opinion, the so-identified exception(s) provided in
      this definition of "Excluded Information" do not apply to the identified
      Confidential Information, then the disclosing party will be deemed to have
      waived any objection to the identified use or disclosure of the identified
      Confidential Information. If, however, the disclosing party objects within
      such time period to the identified use or disclosure of the identified
      Confidential Information, then the recipient will not make such use or
      disclosure without:

      (a)   the written consent of the disclosing party; or

      (b)   complying with the dispute resolution provisions of clause 25
            hereof.

      "Executive Service Agreement" means the agreement annexed to this
      Agreement and marked "D".

      "Group" means (in relation to AVAX Holdings) AVAX Holdings and its Related
      Bodies Corporate and means (in relation to NIHL Sub) NIHL Sub and its
      Related Bodies Corporate and means (in relation to Additional
      Shareholders) the Additional Shareholders and their respective Related
      Bodies Corporate.

      "GST" means any goods and services tax implemented in Australia under any
      legislation (such legislation including without limitation the A New Tax
      System (Goods and Services Tax) Act 1999).

      "holding company" has the meaning given in section 9 of the Corporations
      Law.


                                                                               4
<PAGE>

      "Introduction" means the introduction by one party to another party of
      third parties involved or proposed to be involved in the Business.

      "Joint Venture" means the incorporated joint venture between the
      Shareholders formed and governed by this Agreement.

      "Licensed Products" means (in relation to AVAX Australia) those products
      referred to as "Products" in the AVAX Australia Licence and Distribution
      Agreement and means (in relation to AVAX Manufacturing) those products
      referred to as "Products" in the AVAX Manufacturing Licence Agreement.

      "Material Contract" means any contract to which a Company is party that:

      (b)   potentially affects the value of the assets or liabilities of the
            relevant Company by $50,000 or more;

      (c)   involves capital expenditure by the relevant Company in excess of
            $50,000;

      (d)   may result in a significant or permanent change to the nature or
            operation of the Business; or

      (e)   relates to key personnel or the supply of key services to the
            relevant Company.

      "NIHL Option Deed" means the deed annexed to this Agreement and marked
      "E".

      "Non-Voting Shares" means shares in the Companies that have the same
      dividend rights as "A" Class Ordinary Shares but do not carry any voting
      rights in any circumstances.

      "Obligations" means all of the obligations of NIHL Sub and NIHL ServiceCo
      under this Agreement.

      "Ordinary Shares" means the "A" Class Ordinary Shares, the "B" Class
      Ordinary Shares and the "C" Class Ordinary Shares and, for the avoidance
      of doubt, excludes the Non-Voting Shares.

      "Originators" means the parties who created the intellectual property
      which enables the manufacture of the Licensed Products and who granted to
      AVAX Holdings the right to license those rights.

                                                                               5
<PAGE>

      "Proprietary Property" means all trade secrets, confidential information,
      designs, technical drawings, processes, procedures, formulae,
      specifications and other information relating to the Licensed Products.

      "Related Body Corporate" of an entity means any body corporate which is
      related to that entity within the meaning of the Corporations Law provided
      that, for the purposes of this Agreement, AVAX Australia and AVAX
      Manufacturing shall be deemed not to be Related Bodies Corporate of any of
      the Shareholders.

      "Shares" means issued shares in the Companies from time to time.

      "Shareholder" means one of NIHL Sub or AVAX Holdings or any Additional
      Shareholder and "Shareholders" means all of them.

      "Taxes" means all income, stamp and other taxes, levies, imposts,
      deductions, charges and withholdings plus interest thereon and penalties,
      if any, and charges, fees or other amounts made on or in respect thereof.

      "Territory" means Australia and New Zealand.

      "Transaction Agreements" means this Agreement, the AVAX Australia Licence
      and Distribution Agreement, the AVAX Manufacturing Licence Agreement and
      the Development Agreement or any of them.

      "Working Capital" means TEN MILLION DOLLARS ($10,000,000) to be
      contributed by NIHL Sub to AVAX Australia. The parties acknowledge that
      the working capital needs of the Companies include research and
      development for the Licensed Products.

1.2   Interpretation

      In this Agreement:

      (a)   headings are for convenience only and do not affect interpretation;

      and unless the context indicates a contrary intention:

      (b)   the expression "person" includes an individual, the estate of an
            individual, a corporation, an authority, an association or a joint
            venture (whether incorporated or unincorporated), a partnership and
            a trust;

      (c)   a reference to any party includes that party's executors,
            administrators, successors and permitted assigns, including any
            person taking by way of novation;

                                                                               6
<PAGE>

      (d)   a reference to any document (including this Agreement) is to that
            document as varied, novated, ratified or replaced from time to time;

      (e)   a reference to any statute or to any statutory provision includes
            any statutory modification or re-enactment of it or any statutory
            provision substituted for it, and all ordinances, by-laws,
            regulations, rules and statutory instruments (however described)
            issued under it;

      (f)   words importing the singular include the plural (and vice versa),
            and words indicating a gender include every other gender;

      (g)   references to parties, clauses, schedules, exhibits or annexures are
            references to parties, clauses, schedules, exhibits and annexures to
            or of this Agreement, and a reference to this Agreement includes any
            schedule, exhibit or annexure to this Agreement;

      (h)   where a word or phrase is given a defined meaning, any other part of
            speech or grammatical form of that word or phrase has a
            corresponding meaning; and

      (i)   a reference to "$" or "dollar" is to Australian currency.

1.3   Recitals and annexures

      The Recitals and annexures form part of this Agreement, and defined terms
      in the Recitals have the meaning given them in clause 1.1.

2.    THE COMPANIES

2.1   Current Shareholdings

      The Shareholders acknowledge that AVAX Holdings currently holds the whole
      of the issued capital of the Companies.

2.2   Division of share capital in the Companies

      The issued capital of the Companies will be divided into:

      (a)   "A" Class Ordinary Shares which will be held by AVAX Holdings;

      (b)   "B" Class Ordinary Shares which will be held by NIHL Sub;

                                                                               7
<PAGE>

      (c)   "C" Class Ordinary Shares which will be held by Additional
            Shareholders, if any; and

      (d)   Non-Voting Shares which will be held by AVAX Holdings.

      The only differentiation between the "A" Class Ordinary Shares, the "B"
      Class Ordinary Shares and the "C" Class Ordinary Shares will be the
      different voting rights to be exercised by the Directors appointed by the
      holders of those Ordinary Shares, as described in clause 5 and clause
      15.2(e)(i).

2.3   Subscription for Shares

      AVAX Holdings will, if it has not already done so, subscribe for
      sufficient Shares so that it holds 5,200 "A" Class Ordinary Shares in each
      of the Companies for a total consideration of $104 ($52 for each Company)
      and will pay the Companies for its said Shares in full upon subscribing.

2.4   Constitutions

      (a)   At the request of any Shareholder, the Constitutions will be amended
            so as to be consistent with the terms of this Agreement.

      (b)   If there is any inconsistency between the provisions of this
            Agreement and a Constitution, the former will prevail to the extent
            of the inconsistency.

2.5      First Directors

      (a)   The first Directors of AVAX Australia will be Jeffrey Martin Jonas,
            David Lothrop Tousley and Kelvin Edward Hopper (who will be regarded
            as having been appointed by AVAX Holdings) and Peter Buchanan
            Simpson, Richard Langley Stewart Hill and Hudson Hak Fun Chen (who
            will be regarded as having been appointed by NIHL Sub).

      (b)   The first Directors of AVAX Manufacturing will be Jeffrey Martin
            Jonas, Ernest Warren Yankee and Kelvin Edward Hopper (who will be
            regarded as having been appointed by AVAX Holdings) and Peter
            Buchanan Simpson, Richard Langley Stewart Hill and Hudson Hak Fun
            Chen (who will be regarded as having been appointed by NIHL Sub).

2.6      Secretary and public officer

      The first secretary of the Companies will be Peter Buchanan Simpson and
      the first public officer will be Peter Buchanan Simpson.


                                                                               8
<PAGE>

2.7   Registered office

      The registered office of the Companies will be c/- Clayton Utz, Level 31,
      1 O'Connell Street, Sydney, Australia or at such other location as
      determined by the Directors.

2.8   Banking

      The Companies' banker will be the North Sydney (Cnr Miller & Berry
      Streets) branch of the Commonwealth Bank of Australia and the first
      signatory to the Companies' bank account will be Peter Buchanan Simpson,
      except that any cheque for $50,000 or more must be counter-signed by
      Kelvin Edward Hopper or any other person nominated by AVAX Holdings.

2.9   Auditors

      The auditors of the Companies will be Ernst & Young.

2.10  Financial year

      Subject to receipt of the necessary consents from the relevant Australian
      regulatory authorities, the financial year of the Companies will be the 12
      month period from 1 January to 31 December in each year provided that the
      first financial year of the Company will be the period from the date of
      this Agreement until the next following 31 December.

3.    BUSINESS OF THE COMPANIES

3.1   Nature of business

      (a)   The business of AVAX Australia will be the sale and distribution of
            the Licensed Products in accordance with the AVAX Australia Licence
            and Distribution Agreement.

      (b)   The business of AVAX Manufacturing will be the manufacture of the
            Licensed Products in accordance with the AVAX Manufacturing Licence
            Agreement and the conduct of research and development in relation to
            the Licensed Products in accordance with the Development Agreement.

3.2   Place where Business will be carried on

      The Business of the Companies will be carried on in the Territory.


                                                                               9
<PAGE>

4.    CONTRIBUTION OF WORKING CAPITAL AND OWNERSHIP OF THE COMPANIES

4.1   Initial ownership

      (a)   AVAX Holdings will initially own the whole of the issued capital of
            the Companies.

      (b)   Subject to clause 4.4, NIHL Sub will earn up to a 50% interest in
            the Companies by the contribution of Working Capital pursuant to
            clause 4.2.

4.2   Contribution of Working Capital by NIHL Sub

      NIHL Sub will contribute the Working Capital to AVAX Australia in
      accordance with the following:

      (a)   $3,600,000 on the date of execution of this Agreement;

      (b)   $400,000 on the date which is 30 days after the date of execution of
            this Agreement;

      (c)   subject to clause 4.4, $3,000,000 on 31 March 2000; and

      (d)   subject to clause 4.4, $3,000,000 on 30 June 2000.

4.3   Issue of Shares following contribution of Working Capital

      Upon NIHL Sub:

      (a)   making the contribution referred to in clause 4.2(a), AVAX Holdings
            will procure that the Companies issue to NIHL Sub:

            (i)   1,141 "B" Class Ordinary Shares in AVAX Australia for a total
                  consideration of $3,598,859; and

            (ii)  1,141 "B" Class Ordinary Shares in AVAX Manufacturing for a
                  total consideration of $1,141,

            such that AVAX Holdings holds 82% of the Ordinary Shares and NIHL
            Sub holds 18% of the Ordinary Shares;

      (b)   making the contribution referred to in clause 4.2(b), the
            Shareholders will procure that the Companies issue to NIHL Sub:

                                                                              10
<PAGE>

            (i)   159 "B" Class Ordinary Shares in AVAX Australia for a total
                  consideration of $399,841; and

            (ii)  159 "B" Class Ordinary Shares in AVAX Manufacturing for a
                  total consideration of $159,

            such that AVAX Holdings holds 80% of the Ordinary Shares and NIHL
            Sub holds 20% of the Ordinary Shares;

      (c)   making the contribution referred to in clause 4.2(c), the
            Shareholders will procure that the Companies issue to NIHL Sub:

            (i)   1,500 "B" Class Ordinary Shares in AVAX Australia for a total
                  consideration of $2,998,500; and

            (ii)  1,500 "B" Class Ordinary Shares in AVAX Manufacturing for a
                  total consideration of $1,500,

            such that AVAX Holdings holds 65% of the Ordinary Shares and NIHL
            Sub holds 35% of the Ordinary Shares; and

      (d)   making the contribution referred to in clause 4.2(d), the
            Shareholders will procure that the Companies issue:

            (i)   to NIHL Sub:

                  A.    2,400 "B" Class Ordinary Shares in AVAX Australia for a
                        total consideration of $2,997,600; and

                  B.    2,400 "B" Class Ordinary Shares in AVAX Manufacturing
                        for a total consideration of $2,400; and

            (ii)  to AVAX Holdings, 10 Non-Voting Shares in each of the
                  Companies for a total consideration of $20 ($10 for each
                  Company),

            such that AVAX Holdings holds 50% of the Ordinary Shares and NIHL
            Sub holds 50% of the Ordinary Shares and AVAX Holdings holds all of
            the Non-Voting Shares.

4.4   Election to contribute Working Capital

      (a)   NIHL Sub must make the contributions referred to in clauses 4.2(a)
            and (b) and has no right to elect otherwise.


                                                                              11
<PAGE>

      (b)   NIHL Sub must, prior to the dates referred to in clauses 4.2(c) and
            (d), elect in writing to AVAX Holdings whether or not it will make
            the relevant contribution, with such election being binding upon
            NIHL Sub.

      (c)   If NIHL Sub fails to make an election in accordance with paragraph
            (b), it will be deemed to have elected to make the relevant
            contribution provided that NIHL Sub will not be entitled to elect to
            make a contribution, and will not be deemed to have elected to make
            that contribution, where the previous contribution due from NIHL Sub
            has not been paid in full.

4.5   Payment of Working Capital

      NIHL Sub will pay the contributions referred to in clause 4.2 into bank
      accounts respectively nominated by AVAX Australia and AVAX Manufacturing
      for the amounts referred to in clause 4.3.

4.6   Equal ownership proportions

      Each Shareholder must at all times hold the same proportion of the issued
      capital of AVAX Australia as it does in AVAX Manufacturing.

4.7   Funding of AVAX Manufacturing

      The Shareholders will ensure that AVAX Australia provides loan funds to
      AVAX Manufacturing in such amounts and on such terms as the respective
      Boards of Directors of the Companies from time to time agree.

4.8   Further contributions

      Subject to the provisions of this clause 4, neither Shareholder will be
      obliged to contribute further funds to the Companies either by way of loan
      or subscription for Shares unless otherwise agreed in writing.

5.    DIRECTORS OF THE COMPANIES

5.1   Number of Directors

      Subject to clauses 5.2 and 15.2(e)(i), the number of Directors of the
      Companies will be 6.

5.2   Appointment of Directors


                                                                              12
<PAGE>

      (a)   Subject to clauses 5.2(b), (c) and (d), each of AVAX Holdings and
            NIHL Sub will be entitled to appoint 3 nominees to the Boards of the
            Companies and will be entitled to replace any such nominee.

      (b)   If NIHL Sub does not make the contribution referred to in clause
            4.2(a), NIHL Sub:

            (i)   will not be entitled to appoint any nominees to the Boards of
                  the Companies;

            (ii)  will cause the nominees of NIHL Sub (if any) to resign from
                  their office as Director forthwith; and

            (iii) will lose its rights under clause 5.4(b).

      (c)   If NIHL Sub does not make the contribution referred to in clause
            4.2(b) or clause 4.2(c), NIHL Sub:

            (i)   will only be entitled to appoint one nominee to the Boards of
                  the Companies and will be entitled to replace any such
                  nominee; and

            (ii)  will cause the other 2 nominees of NIHL Sub to resign from
                  their office as Director forthwith.

(d)              If NIHL Sub makes the contribution referred to in clause 4.2(c)
                 but does not make the contribution referred to in clause
                 4.2(d), NIHL Sub:

            (i)   will only be entitled to appoint 2 nominees to the Boards of
                  the Companies and will be entitled to replace any such
                  nominee; and

            (ii)  will cause the other nominee of NIHL Sub to resign from his or
                  her office as Director forthwith.

5.3   Alternate Directors

      Each Director will have power to appoint any person, who is approved for
      that purpose by a majority of the other Directors after receipt of an
      instrument appointing an alternate director, to be the alternate of the
      Director to act in his place during such times as such Director
      determines.

5.4   Directors' votes


                                                                              13
<PAGE>

      (a)   Those Directors nominated by AVAX Holdings will be entitled to a
            vote equal to the percentage of the Ordinary Shares owned by AVAX
            Holdings.

      (b)   Subject to clause 5.2(b), those Directors nominated by NIHL Sub will
            be entitled to a vote equal to the percentage of the Ordinary Shares
            owned by NIHL Sub.

      (c)   Those Directors nominated by Additional Shareholders, if any, will
            be entitled to a vote equal to the percentage of the Ordinary Shares
            owned by Additional Shareholders.

      (d)   If less than all nominees of a Shareholder attend a meeting of
            Directors, the attending nominee(s) may exercise all of the
            Directors' votes referred to in paragraph (a), (b) or (c) (as
            appropriate).

      (e)   The Chairman of Directors will not, in the case of an equality of
            votes, have a second or casting vote.

5.5   Quorum for meetings of Directors and Shareholders

      (a)   Subject to clause 5.5(b), the quorum for a meeting of Directors or
            members of the Companies will be one representative from each of
            AVAX Holdings, NIHL Sub and (if applicable) Additional Shareholders.

      (b)   The quorum for a meeting of Directors of the Companies at which any
            decision set out in clauses 7.4(a) to (j) will be made will be all
            Directors of the relevant Company.

      (c)   Each of the Shareholders will use its reasonable endeavours to
            ensure that:

            (i)   at least one representative from that Shareholder attends each
                  meeting of Directors or members of the Companies referred to
                  in clause 5.5(a); and

            (ii)  all Directors attend each meeting of Directors of the
                  Companies referred to in clause 5.5(b).

5.6      Use of technology for meetings

         The Directors may confer or hold meetings through the use of any
         technology, including radio, telephone, closed circuit television or
         other electronic means or telecommunications device for audio or
         audio-visual communication.


                                                                              14
<PAGE>

6.    CHAIRMAN OF THE BOARD

      The Shareholders will cause the Directors to elect a chairman of the
      Companies and to elect him according to the following rules:

      (a)   until 31 December 2000 the chairman of the Companies will be a
            Director appointed by AVAX Holdings;

      (b)   subject to paragraph (c):

            (i)   during the calendar year immediately following 31 December
                  2000, the chairman of the Companies will be a Director
                  appointed by NIHL Sub; and

            (ii)  during subsequent calendar years, the chairmanship of the
                  Companies will alternate between a Director appointed by AVAX
                  Holdings and a Director appointed by NIHL Sub;

      (c)   whilstever NIHL Sub holds less than 50% of the Ordinary Shares, the
            chairman of the Companies will be a Director appointed by AVAX
            Holdings.

7.    MANAGEMENT OF THE COMPANIES

7.1   Conduct of Business

      The Boards of Directors of the Companies will control the manner in which
      the Business is conducted.

7.2   Business plans

      The Shareholders will cause the Directors to prepare or have prepared in
      relation to each financial year of the Companies a business plan and
      annual budget and will cause the Directors of the Companies to see that
      during the relevant financial year the Business is managed in accordance
      with the relevant business plan and annual budget.

7.3   Expenditure by management

      Any item or items of expenditure in excess of $50,000 in relation to any
      one capital item or an aggregate of $50,000 per annum in respect of
      expense items for either Company will to the extent that such expenditure
      is not provided for in the relevant business plan and annual budget
      require the prior approval of the relevant Board of


                                                                              15
<PAGE>

      Directors before any commitment in relation thereto is entered into by the
      relevant Company.

7.4   Board decisions

      Decisions of the Boards of Directors of the Companies will be by simple
      majority of all Directors of the respective Company, except that, subject
      to clause 15.2(d), the following decisions will require a special majority
      of not less than 85% up to 31 March 2000, not less than 70% from 31 March
      2000 to 30 June 2000 and not less than 65% thereafter:

      (a)   pursuant to clause 7.3, expenditures in excess of $50,000;

      (b)   entry into, or termination of, a Material Contract;

      (c)   termination of operations;

      (d)   disposal of the Business;

      (e)   material change in the Business;

      (f)   corporate restructure;

      (g)   establishment of and later changes to planning and strategy relating
            to:

            (i)   regulatory compliance and development;

            (ii)  intellectual property; and

            (iii) manufacturing;

      (h)   approval of a business plan or annual budget for the Business;

      (i)   decisions materially affecting the parties' respective rights in
            respect of the licensing of rights relating to the Licensed
            Products; and

      (j)   subject to clause 15.2(e), any issue of Shares other than as
            provided for in this Agreement.

7.5   No materially prejudicial action

      Notwithstanding the provisions of clause 7.4, but subject to clause 15.2,
      neither Shareholder will act in a manner likely to materially prejudice
      the interests of the other Shareholder in relation to the Joint Venture,
      except where:


                                                                              16
<PAGE>

      (a)   the other Shareholder is in breach of this Agreement or any other
            Transaction Agreement; or

      (b)   the firstmentioned Shareholder is acting in accordance with the
            terms of this Agreement,

      and each Shareholder will procure that none of their respective Related
      Bodies Corporate so act.

7.6   Peter Buchanan Simpson

      NIHL Sub will procure that Peter Buchanan Simpson acts as Managing
      Director of the Companies to assist in the management of the Business for
      a minimum period of 2 years and, in this regard, will procure that Peter
      Buchanan Simpson enters into the Executive Service Agreement.

7.7   Obligations of NIHL ServiceCo

      NIHL ServiceCo will:

            (a)   locate and recommend the employment of appropriate persons to
                  manage the Companies;

            (b)   establish the means to conduct the Business;

            (c)   advise AVAX Australia on matters to commercialise and develop
                  the Licensed Products in the Territory;

            (d)   provide management of the marketing and sales for AVAX
                  Australia,

      and will:

            (e)   enter into a contract to that effect satisfactory to AVAX
                  Holdings, if required;

            (f)   provide quarterly reports to AVAX Australia summarising the
                  results of its activities referred to in paragraphs (a) to (d)
                  above; and

            (g)   where required by the GST law, issue a tax invoice or other
                  documentation which enables AVAX Australia to claim a credit
                  or refund of GST in a timely manner.

7.8   NIHL ServiceCo fee


                                                                              17
<PAGE>

      (a)   Subject to clause 7.8(b), in consideration of the services provided
            by NIHL ServiceCo under clause 7.7, the Shareholders will agree upon
            a quarterly fee (if any) ("NIHL ServiceCo Fee") to be paid by AVAX
            Australia to NIHL ServiceCo for such services and will procure that
            AVAX Australia pays the NIHL ServiceCo Fee to NIHL ServiceCo.

      (b)   Whilstever AVAX Australia is either unprofitable or has profits less
            than the NIHL ServiceCo Fee, NIHL ServiceCo will not receive a fee
            pursuant to clause 7.8(a), unless otherwise agreed in writing by the
            parties.

7.9   Technical Services

      Technical services will only be provided to the Companies:

      (a)   by AVAX Technologies or one of its Related Bodies Corporate; and

      (b)   at the request of and on terms approved by the Managing Director of
            the relevant Company,

      unless otherwise agreed by the parties.

8.    TRANSACTION AGREEMENTS

8.1   Contemporaneous Execution

      Each of the Shareholders acknowledge that all of the Transaction
      Agreements will be entered into contemporaneously and, where necessary,
      will procure that the Companies, as applicable, enter into the Transaction
      Agreements.

8.2   Compliance with Transaction Agreements

      The Shareholders will procure that the Directors vote in such a manner so
      as to ensure that the Companies comply with all of their obligations under
      the Transaction Agreements.

9.    NIHL OPTIONS

      Contemporaneously with this Agreement, NIHL will enter into the NIHL
      Option Deed with AVAX Technologies pursuant to which NIHL will grant to
      AVAX Technologies options to acquire 5.03% of the issued share capital of
      NIHL as at the date of this Agreement.

10.   CONFIDENTIALITY


                                                                              18
<PAGE>

10.1  Confidential Information and Proprietary Property

      In consideration for access to the Proprietary Property being granted to
      NIHL Sub and the Companies, each of NIHL, NIHL Sub and NIHL ServiceCo
      acknowledges and agrees that:

      (a)   the Confidential Information is disclosed to NIHL Sub (and NIHL and
            NIHL ServiceCo , if applicable) in confidence and is and will at all
            times be owned by AVAX Holdings or some Related Body Corporate of
            AVAX Holdings (other than AVAX Australia or AVAX Manufacturing) and
            it will not claim any ownership interest in the Proprietary
            Property, either for itself or for AVAX Australia or AVAX
            Manufacturing;

      (b)   it must, subject to the terms of this Agreement, hold all
            Confidential Information and/or Proprietary Property in strict
            confidence;

      (c)   it must not reveal any Confidential Information and/or Proprietary
            Property to any person except strictly on a need-to-know basis to
            persons approved in writing by AVAX Holdings and for the purposes of
            this Agreement and to persons who have executed written
            confidentiality undertakings at least as comprehensive as provided
            in this Agreement, a copy of which will be provided to AVAX
            Holdings;

      (d)   it will not use any Confidential Information and/or Proprietary
            Property except for the purposes of this Agreement;

      (e)   it must take all reasonable steps to ensure that its officers,
            employees, contractors and agents also observe the obligations of
            these provisions; and

      (f)   it will not make, use, sell, duplicate, transfer or have made, used,
            sold, duplicated or transferred to others (except AVAX Holdings or
            any of its Related Bodies Corporate) or assist or permit any other
            party to make, use, sell, duplicate, transfer any product or process
            in whole or in part comprising or incorporating any of the
            Proprietary Property without the prior written permission of AVAX
            Holdings. Only after obtaining such written permission from AVAX
            Holdings may NIHL Sub permit any third party to have any access to
            or use any of the Proprietary Property.

10.2  Disclosure

      For the purposes of this Agreement, it is agreed that each of the parties
      may disclose those terms of the Transaction Agreements and any other
      agreements between AVAX Holdings, AVAX Australia, AVAX Technologies, AVAX
      International IP


                                       19
<PAGE>

      Holdings Inc and the Originators relating to the Licensed Products as is
      necessary to enable them to observe their legal obligations, whether
      arising under the Corporations Law, the Official Listing Rules of the
      Australian Stock Exchange Limited or the United States Securities Exchange
      Commission or otherwise, provided that the party first provides written
      notice to each of the other parties of the exact terms of the intended
      disclosure and obtains the written consent of each of the other parties to
      the disclosure, which consent will not be unreasonably withheld.

11.   CONFIDENTIALITY OF COMMERCIAL CONTACTS

11.1  Subject to the provisions of clause 10, each of the parties covenant and
      agree with each other that:

      (a)   an Introduction may lead to Contacts;

      (b)   the Contacts are the result of the acts of the other party and are
            the property of the other party and, unless authorised in writing by
            the other party, should not be used for any purpose other than in
            relation to the Business; and

      (c)   in consideration of the Introduction and the disclosure of the
            Confidential Information they will not disclose any Contact or
            attempt to negotiate or negotiate or attempt to participate or
            participate in any transaction with any Contact unless authorised in
            writing by the other party.

11.2  Each of the parties covenant and agree with each other that in
      consideration of the Introduction and disclosure of the Confidential
      Information, unless authorised in writing by each other party they will:

      (a)   keep absolutely secret the fact of supply and all of the
            Confidential Information received by it;

      (b)   not make or cause to be made any copy, duplicate, replica, summary,
            precis or otherwise make or construct any document, material or
            thing similar to any of the Confidential Information;

      (c)   not allow any other person, firm, corporation or other entity
            whatsoever to view, read, encode, copy, record whether on computer
            disk, tape or other electronic or mechanical means, or otherwise, to
            come into contact with the Confidential Information;

      (d)   not discuss in detail or general the fact that the Confidential
            Information has been supplied, the purpose of the supply of the
            Confidential


                                                                              20
<PAGE>

            Information or the contents of the Confidential Information with any
            person, firm, corporation or other entity whatsoever;

      (e)   return each copy of the Confidential Information supplied by the
            other party as and when required to do so, without retaining any
            copies or allowing any other entity to do so; and

      (f)   not utilise in any way directly or indirectly any Confidential
            Information supplied by the other party to its financial, managerial
            or strategic benefit or to the financial, managerial and strategic
            detriment of the other party however such detriment may arise.

11.3  Each of the parties must procure that its Related Bodies Corporate,
      officers, employees, agents and advisers (whether or not still employed or
      engaged in that capacity) do not do or omit to do anything which, if done
      or omitted to be done by them, would be a breach of their obligations
      under this Agreement.

11.4  Each of the parties covenant and agree with each other that their
      covenants in accordance with clause 10 and this clause 11 apply world-wide
      and will continue beyond the termination of this Agreement until they are
      released in writing by all other parties.

11.5  Each of the parties acknowledges that damages are not a sufficient remedy
      for any other party for any breach of clauses 10 and 11 hereof and the
      party whose rights under clauses 10 and 11 hereof are breached is entitled
      to specific performance or injunctive relief (as appropriate) as a remedy
      for any such breach or threatened breach by any other party in addition to
      any other remedies available at equity or in law.

12.   NO COMPETITION WITH THE COMPANIES

12.1  During the term of this Agreement

      Subject to clause 12.3, each Shareholder covenants with the other
      Shareholder(s) and for the benefit of the Companies that while any member
      of the firstmentioned Shareholder's Group holds Shares, neither the
      firstmentioned Shareholder nor any member of the firstmentioned
      Shareholder's Group will, without the prior written consent of the other
      Shareholder(s), directly or indirectly engage or otherwise than through
      the Companies, be concerned or interested in any business in the Territory
      which involves the manufacture, development and/or marketing of cancer
      therapeutics, whether on its own or as an associate of another person.

12.2  Covenant not to compete


                                                                              21
<PAGE>

      (a)   Subject to clause 12.3, in the event that a Shareholder(s):

            (i)   acquires another Shareholder's interest in the Companies
                  pursuant to clause 14.7(a); or

            (ii)  terminates this Agreement pursuant to clause 14.7(b),

            neither the defaulting party (as defined in clause 14.6) nor any
            member of the defaulting party's Group will, without the prior
            written consent of the other Shareholder(s), directly or indirectly,
            engage, be concerned or interested in any business in the Territory
            which involves the manufacture, development and/or marketing of
            cancer therapeutics, whether on its own or as an associate of
            another person for 3 calendar years thereafter.

      (b)   Subject to clause 12.3, in the event that AVAX Holdings exercises
            its option pursuant to clause 15.2(c), neither NIHL Sub nor any
            member of NIHL Sub's Group will, without the prior written consent
            of AVAX Holdings, directly or indirectly, engage, be concerned or
            interested in any business in the Territory which involves the
            manufacture, development and/or marketing of cancer vaccines or
            immunotherapies, whether on its own or as an associate of another
            person for 3 calendar years thereafter.

12.3  Exceptions

      The restrictions imposed by clauses 12.1 and 12.2 will not apply to:

      (a)   any holding by any member of either Group of shares in a listed
            company which confer not more than 5% of the votes which could be
            cast at a general meeting of the company concerned on matters and in
            circumstances not being such as to bring into play any special
            voting rights or restrictions on voting rights;

      (b)   any interest which any member of either Group has for no longer than
            6 months after it has become a member of its Group and which arises
            as a result of an acquisition of a corporation the business of which
            does not consist mainly of a business the same as or similar to the
            Business; or

      (c)   any holding by any member of either Group of shares in a company
            which was previously a member of that Group while the Group's shares
            in the company confer the right to not more than 5% of the dividends
            payable by the company and confer not more than 5% of the votes
            which could be cast at a general meeting of the company on matters
            and in circumstances not being such as to bring into play any
            special voting rights or restrictions on voting rights.


                                                                              22
<PAGE>

13.   FINANCIAL REPORTS AND DIVIDEND AND BORROWING POLICIES

13.1  Financial reports

      The Shareholders will ensure that each of the Companies:

      (a)   causes its financial affairs to be audited in accordance with
            statutory requirements at the end of each financial year and at the
            request and cost of the requesting Shareholder at such other times
            as either Shareholder may request;

      (b)   provides to each of the Directors and to each of the Shareholders as
            soon as available, and in any event within 60 days after the end of
            each financial year of the Companies, a copy of its audited balance
            sheet as at the end of that financial year, and a copy of its
            audited profit and loss account for that financial year in all
            reasonable detail and subject to any contrary determination by the
            Directors prepared in conformity with generally accepted Australian
            accounting principles and practices at the relevant time (including
            the Australian Accounting Standards and the Approved Accounting
            Standards) consistently applied;

      (c)   provides to each of the Directors as soon as available, and in any
            event not later than 60 days after the end of each financial half
            year, a copy of its balance sheet at the end of that financial half
            year and a copy of its profit and loss account for that financial
            half year prepared in reasonable detail sufficient to present to the
            auditors of the Companies if an audit is required by either
            Shareholder;

      (d)   provides such figures and confirmations to each Shareholder as may
            be reasonably required by that Shareholder for inclusion in or for
            the preparation of its own accounts and reports within 30 days after
            the end of each financial half year and each financial year of that
            Shareholder or within such other period as may be agreed upon by the
            Shareholders; and

      (e)   provides to each of the Directors and to each Shareholder within 21
            days after the end of the relevant month all monthly reports and as
            soon as available other financial accounts, projections, budgets and
            reports that may be prepared on its behalf from time to time as well
            as any other information as may be required by the Directors from
            time to time.

13.2     Profits of AVAX Australia


                                                                              23
<PAGE>

      The Shareholders will co-operate to ensure that unless otherwise
      determined by the Directors:

      (a)   AVAX Australia is managed so as to maximise its long term Profits
            (as defined in clause 13.3) and the return on its Shareholders'
            funds in the long term and so as to make the most profitable use of
            its resources; and

      (b)   the whole of the Profits of AVAX Australia arising in each financial
            year are distributed by way of dividend in accordance with this
            Agreement.

13.3  Meaning of "Profits"

      In this clause 13 the expression "Profits" means the actual realised
      profits of a Company available for distribution after tax in accordance
      with Australian law after excluding any profits arising on the revaluation
      of the Company's assets from time to time plus:

      (a)   the markup referred to in clause 13.6(b)(i); and

      (b)   the fee referred to in clause 13.6(b)(ii).

13.4  Declaration of dividends

      Unless otherwise determined by the Directors the Shareholders will cause
      it to be the case that the Directors make the following declarations of
      dividend to the Shareholders in each financial year:

      (a)   by 30 April an interim dividend of an amount equal to the Profits as
            subsequently determined for the first 3 months of the financial
            year;

      (b)   by 31 July an interim dividend of an amount equal to the Profits as
            subsequently determined for the first half of the financial year;

      (c)   by 31 October an interim dividend of an amount equal to the Profits
            as subsequently determined for the first 9 months of the financial
            year;

      (d)   by 31 January or the day following the annual general meeting of the
            Company, whichever is the later, a final dividend of an amount equal
            to the Profits as subsequently determined for the financial year;
            and

      (e)   at any other time determined by the Directors such dividend or
            interim dividend as such Directors determine,


                                                                              24
<PAGE>

      in each case after deducting the amount of any previous interim dividend
      declared in respect of that financial year and after making provision for
      any loss expected to be incurred during the remainder of the financial
      year.

13.5  Payment of dividends

      The Shareholders will cause it to be the case that any interim dividend
      declared as aforesaid will be paid by the relevant Company promptly after
      the date of declaration and that any final dividend will be declared and
      paid promptly after the annual general meeting of the Company at which the
      relevant accounts of the Company are approved by the Shareholders.

13.6  Dividend entitlement

      (a)   Notwithstanding any other provision of this Agreement (other than
            this clause 13.6) or the other Transaction Agreements, the Profits
            of the Companies will be distributed to the Shareholders by way of
            dividend in such a manner as to ensure that each Shareholder
            receives Profits in proportion to the number of Ordinary Shares and
            Non-Voting Shares held by that Shareholder.

      (b)   Solely for the purposes of calculating the proportion of Profits to
            be paid by way of dividend to the Shareholders:

            (i)   any markup earnt by AVAX Holdings pursuant to clause 3.2 of
                  the AVAX Australia Licence and Distribution Agreement will be
                  notionally treated as Profit received by AVAX Holdings;

            (ii)  any fee paid to NIHL ServiceCo pursuant to clause 7.8 of this
                  Agreement will be notionally treated as Profit received by
                  NIHL Sub;

            (iii) the licence fee payable to AVAX Holdings under clause 10.3 of
                  the AVAX Australia Licence and Distribution Agreement will be
                  recognised as an expense of AVAX Australia and will not be
                  notionally treated as Profit received by AVAX Holdings;

            (iv)  any additional Taxes (excluding GST) incurred by AVAX
                  Australia as a direct result of the procedure whereby Licensed
                  Products are manufactured by AVAX Manufacturing and first sold
                  to AVAX Holdings before being sold to AVAX Australia will be
                  notionally treated as Profit received by AVAX Holdings; and


                                                                              25
<PAGE>

            (v)   any additional Taxes (excluding GST) incurred by AVAX
                  Australia as a direct result of any fee paid to NIHL Sub
                  pursuant to clause 7.8 of this Agreement will be notionally
                  treated as Profit received by NIHL Sub.

            For the avoidance of doubt, the parties agree that additional Taxes
            will be deemed to be incurred by AVAX Australia if, in the case of
            AVAX Holdings, the amount of the markup referred to in clause
            13.6(b)(i) is not claimable by AVAX Australia as a tax deduction
            and, in the case of NIHL Sub, the amount of the fee referred to in
            clause 13.6(b)(ii) is not claimable by AVAX Australia as a tax
            deduction.

13.7  Disputes

      Any dispute, controversy or claim arising from the distribution of Profits
      pursuant to clause 13.6 will be referred to and finally settled in
      accordance with clause 25, provided that the Shareholders shall first seek
      an opinion from the auditors of the Company concerned.

14.   CHANGE OF CONTROL, DEFAULT AND LIQUIDATION

14.1  Effect

      Each of the Shareholders covenant and agree with each other that in the
      event that:

      (a)   subject to clause 14.3, a person who is at the date of this
            Agreement entitled to less than 10% of the voting shares of a
            Shareholder ("target company"):

            (i)   becomes entitled to more than 10% of the voting shares of the
                  target company; and

            (ii)  at any time thereafter finds himself in a situation whereunder
                  he and/or his associates constitute half or more of the board
                  of directors of the target company or whereunder the board of
                  directors of the target company customarily acts in accordance
                  with the wishes of that person and/or his associates or
                  customarily consults with that person and/or his associates in
                  relation to major business decisions of the target company; or

      (b)   an Event of Default occurs and the defaulting party fails to remedy
            the default within 30 days after written notice from any other
            Shareholder requiring it to do so; or


                                                                              26
<PAGE>

      (c)   a Shareholder is in breach of any of its material obligations under
            this Agreement and fails to remedy such breach within 30 days after
            written notice to that Shareholder from any other Shareholder
            requiring it to do so; or

      (d)   there is a persistent or serious failure by a Shareholder to comply
            with the terms of this Agreement or any further or other agreement
            entered into pursuant to the terms of this Agreement; or

      (e)   NIHL Sub does not make the contribution referred to in clause 4.2(a)
            or clause 4.2(b) or following an election, or a deemed election, by
            NIHL Sub to make a further contribution to Working Capital pursuant
            to clause 4.4, NIHL Sub fails to make the relevant contribution to
            Working Capital,

      the provisions of clause 14.7 will apply.

14.2  Events of Default

      Each of the Shareholders covenant and agree with each other that for the
      purpose of clause 14.1(b), the following will be the Events of Default:

      (a)   if a petition is presented or a resolution is passed for the
            winding-up of a party or a notice of intention to propose such
            resolution is given (except for the purposes of reconstruction or
            amalgamation);

      (b)   if a receiver of the undertaking of or any part of the income of the
            party is appointed;

      (c)   if any part of the assets of any party is resumed or confiscated or
            fortified and in the reasonable opinion of the other party such
            event would prejudice the carrying out of the obligations of the
            party so affected;

      (d)   if any distress of execution is issued against any party or any of
            the assets thereof for any amount in excess of $10,000 and is not
            stayed or satisfied within 7 days;

      (e)   if a party ceases to carry on business or stops or suspends payment
            or states its intention to do so;

      (f)   if a party is unable to pay its creditors within the meaning of the
            Corporations Law or proposes or makes a composition or arrangement
            with its creditors or any of them;


                                                                              27
<PAGE>

      (g)   if a party without the prior written consent of the other party has
            reduced or attempts to reduce its capital; and

      (h)   if a party is placed under official management or if a written
            request is received from any creditor thereof to summon a meeting
            therefore.

14.3  Listed companies

      Clause 14.7 will not apply where an entitlement under clause 14.1(a)
      arises as a result of an acquisition of shares in a company whose shares
      are listed on a recognised stock exchange as at the date of this
      Agreement.

14.4  Reconstructions

      Notwithstanding anything contained in clause 14.1(a), clause 14.7 will not
      apply if a corporation becomes the holding company of a Shareholder as a
      result of a corporate reconstruction.

14.5  Breach incapable of being remedied

      For the purposes of clause 14.1(c), a breach which is not a wilful breach
      and which by its nature cannot be remedied will be deemed to have been
      remedied if the act or conduct constituting the breach ceases immediately
      upon receipt of the notice referred to in clause 14.1(c) and does not
      occur again for a period of at least 6 months.

14.6  Meaning of "defaulting party"

      In clauses 14.7, 14.8 and 14.9, the expression the "defaulting party"
      means the target company (as that expression is defined in clause
      14.1(a)); or, as the case may require, the Shareholder in relation to
      which there has occurred one of the events referred to in clause 14.1(b);
      or, as the case may require, the Shareholder mentioned first in clauses
      14.1(c) or (d); or, as the case may require, NIHL Sub in clause 14.1(e).

14.7  Consequences of "default"

      If, by clause 14.1, this clause 14.7 is made to apply, any of the other
      Shareholders will have the right to:

      (a)   acting jointly or individually, acquire the defaulting party's
            interest (pro rata in the event Additional Shareholders exist and
            Shareholders act jointly) in the Companies free of any encumbrance,
            for an amount equal to the value of the defaulting party's interest
            in accordance with clause 14.8; or


                                                                              28
<PAGE>

      (b)   acting jointly, terminate this Agreement in accordance with clause
            14.9.

14.8  Acquisition of defaulting party's interest

      If any other Shareholder(s) elects to exercise its or their rights
      pursuant to clause 14.7(a), the following procedure will apply:

      (a)   the other Shareholder(s) making such election will serve a notice in
            writing ("Election Notice") on the defaulting party not later than
            12 months (in the case of 14.1(a)), 6 months (in the case of 14.1
            (d) or (e)) and one month (in the case of 14.1(b) or (c)) from the
            date upon which such other Shareholder(s) becomes aware of the
            relevant event setting out:

            (i)   such other Shareholder's election to exercise its or their
                  rights pursuant to clause 14.7(a);

            (ii)  a description of the relevant event that created those rights;

      (b)   when an Election Notice has been given, the Shareholders will cause
            their respective chief executive officers to meet and discuss the
            selection of an appropriate valuer to value the defaulting party's
            interest in the Companies no later than one month or any longer
            period which the Shareholders agree upon after the giving of the
            Election Notice and the Shareholders will make bona fide efforts to
            agree upon a valuer within that period;

      (c)   if, at the expiration of the period referred to in paragraph (b),
            the Shareholders have been unable to agree on the selection of a
            valuer, the valuation of the defaulting party's interest in the
            Companies will be referred to arbitration in accordance with clause
            25, the result of which will be binding on the Shareholders;

      (d)   upon receipt of a valuation by the agreed valuer or the arbitrator
            (as the case may be) ("Valuation"), the defaulting party must
            transfer all of its Shares to the other Shareholder(s) who have made
            such election, pro rata in accordance with their respective holdings
            of Ordinary Shares, against payment of a purchase price equal to the
            Valuation, in the manner specified below. Settlement of the sale and
            purchase will occur within 10 days of receipt of the valuer's or
            arbitrator's decision. The defaulting party is obliged to deliver at
            the place nominated for settlement duly executed transfers of its
            Shares, together with all share certificates relating thereto,
            immediately on receipt of full payment (by way of cash or bank
            cheque) for the Shares, but not otherwise;

                                                                              29
<PAGE>

      (e)   the costs of the agreed valuer or arbitrator will either:

            (i)   be paid by the defaulting party from its proceeds of sale; or

            (ii)  deducted from the purchase price and remitted by such other
                  Shareholder(s) to the agreed valuer or arbitrator; and

      (f)   all rights and obligations of the parties under this Agreement with
            respect to the defaulting party will cease from the date of
            settlement of the sale and purchase pursuant to clause 14.8(d)
            (except for the confidentiality provisions in clauses 10 and 11 and
            the non-compete provisions in clause 12).

14.9  Consequences of termination

      If the other Shareholder(s) elects to terminate this Agreement in
      accordance with clause 14.7(b):

      (a)   the other Shareholder(s) making such election will serve a notice in
            writing on the defaulting party not later than 12 months (in the
            case of 14.1(a)), 6 months (in the case of 14.1 (d) or (e)) and one
            month (in the case of 14.1(b) or (c)) from the date upon which such
            other Shareholder(s) becomes aware of the relevant event setting
            out:

            (i)   such other Shareholder's election to exercise its or their
                  rights pursuant to clause 14.7(b); and

            (ii)  a description of the relevant event that created those rights;

      (b)   all rights and obligations of the parties under this Agreement will
            cease from the date of the notice referred to in clause 14.9(a)
            (except for the confidentiality provisions in clauses 10 and 11 and
            the non-compete provisions in clause 12);

      (c)   the assets of the Companies will be sold and any proceeds will be
            distributed to each Shareholder in accordance with the percentage of
            the Ordinary Shares owned by it; and

      (d)   the Shareholders will co-operate to effect the winding-up of the
            Companies.

14.10 Shareholders to cause Directors to give effect to clause 14


                                                                              30
<PAGE>

      Each Shareholder will cause its appointees to the Board of directors or
      the Companies to give effect to this clause 14.

14.11 Rights

      Each of the Shareholders covenant and acknowledge that the exercise of any
      rights pursuant to this clause 14 are without prejudice to any other
      rights accruing to any party.

15.   ELECTION NOT TO CONTRIBUTE WORKING CAPITAL

15.1  Effect

      Notwithstanding any other provision of this Agreement, in the event that:

      (a)   NIHL Sub elects to cease to make further contributions to Working
            Capital pursuant to clause 4.4(b); or

      (b)   NIHL Sub is a defaulting party (as defined in clause 14.6) for the
            purposes of clause 14.1,

      the provisions of clause 15.2 will apply from the date of such election or
      default (as the case may be) in addition, in the circumstances referred to
      in paragraph (b), to the provisions of clause 14.

15.2  Consequences

      If, by clause 15.1, this clause 15.2 is made to apply, the parties agree
      that:

      (a)   NIHL Sub will lose its rights under clause 18 of this Agreement;

      (b)   NIHL Sub will lose its rights under clause 19 of this Agreement;

      (c)   AVAX Holdings will have the option to acquire NIHL Sub's interest in
            the Companies free of any encumbrance, for an amount equal to the
            value of NIHL Sub's interest and, in this regard:

            (i)   the procedure set out in clause 14.8 will apply as though NIHL
                  Sub were a defaulting party; and

            (ii)  the period referred to in clause 14.8(a) will be 6 months;


                                                                              31
<PAGE>

      (d)   the decisions set out in clause 7.4 will no longer require the
            special majorities set out in that clause so that all decisions of
            the Boards of Directors of the Companies will be by simple majority;

      (e)   if directed by AVAX Holdings, as determined in its sole discretion,
            the Companies may issue new shares in the Companies to a third party
            or parties ("Additional Shareholders") and that:

            (i)   each Additional Shareholder will be entitled to appoint 3
                  Directors to the Boards of the Companies who will be entitled
                  to a vote equal to the percentage of the Ordinary Shares owned
                  by the relevant Additional Shareholder;

            (ii)  AVAX Holdings may divulge Confidential Information to
                  prospective and actual Additional Shareholders; and

            (iii) if directed by AVAX Holdings, as determined in its sole
                  discretion, the parties will make whatever other changes to
                  this Agreement as are required to allow an Additional
                  Shareholder to become a party to this Agreement; and

      (f)   the provisions of clause 5.2 shall apply (as appropriate).

16.   PRE-EMPTION RIGHTS WHERE BONA FIDE OFFER

16.1  Disposal

      Subject to clause 16.8, a Shareholder must not dispose of any of its
      Shares unless that Shareholder receives a Bona Fide Offer, in which case
      no Shares will be disposed of unless and until the pre-emption rights in
      this clause 16 have been exhausted.

16.2  Interpretation

      For the purposes of this clause 16:

      "Bona Fide Offer" means a bona fide written offer setting out the terms
      and conditions on which a third party (except a Related Body Corporate of
      a Shareholder) has offered to purchase all (but not some only) of those of
      the Shares held by a Shareholder, including the Purchase Price in
      Australian dollars, being an offer which is open and remains open for
      acceptance at least until the provisions of clause 16.7 apply.

      "dispose" means sell, assign, transfer or otherwise dispose of.


                                                                              32
<PAGE>

      "Offering Shareholder" means a Shareholder proposing to dispose of its
      Shares.

      "Purchase Price" means the cash consideration for the disposal of the Sale
      Shares specified in a Transfer Notice.

      "Sale Shares" means the Shares which are the subject of a Transfer Notice,
      being all (but not some only) of those of the Shares held by the relevant
      Shareholder.

      "Transfer Notice" means a notice in writing to the other Shareholder(s)
      specifying the identity of the third party making the Bona Fide Offer and
      annexing a true and complete copy of the Bona Fide Offer.

16.3  Offering Shareholder to give notice

      An Offering Shareholder must give a Transfer Notice to the other
      Shareholder(s). A Transfer Notice is not revocable except with the
      sanction of the Directors of the Companies.

16.4  Nature of offer

      The Transfer Notice constitutes an offer to sell the Sale Shares for the
      Purchase Price free of any mortgage, charge, lien, encumbrance or adverse
      interest.

16.5  Time

      (a)   A Transfer Notice must be given to the other Shareholder(s) within
            14 days after the date on which the Offering Shareholder receives a
            Bona Fide Offer which it intends, subject to this clause 16, to
            accept.

      (b)   A Transfer Notice must specify the period within which the offer
            constituted by the Transfer Notice may be accepted and will be
            deemed to be declined if not accepted, that period being not less
            than 30 days or more than 60 days, provided that, where consent is
            required under the Foreign Acquisitions and Takeovers Act, that
            period will be no less than 60 days.

16.6  Transfer of Sale Shares

      If the other Shareholder(s) (each an "Accepting Shareholder") accepts the
      offer constituted by the Transfer Notice, the Offering Shareholder must
      transfer the Sale Shares against payment of the Purchase Price in the
      manner specified below. Settlement of the sale and purchase will occur
      within 10 days of the Offering Shareholder becoming bound under this
      clause 16.6 to transfer the Sale Shares to the


                                                                              33
<PAGE>

      Accepting Shareholder(s). The Offering Shareholder is obliged to deliver
      at the place nominated for settlement duly executed transfers of the Sale
      Shares, together with all share certificates relating thereto, immediately
      on receipt of full payment (by way of cash or bank cheque) for the Sale
      Shares, but not otherwise. Unless otherwise agreed by the Accepting
      Shareholder(s), the Accepting Shareholder(s) will purchase the Sale Shares
      pro rata in accordance with their respective holdings of Ordinary Shares.

16.7  Sale to third party

      (a)   If the offer constituted by the Transfer Notice is declined or
            deemed to be declined under clause 16.5(b) or the Accepting
            Shareholder(s) fail to make full and proper payment to the Offering
            Shareholder under clause 16.6, the Offering Shareholder is, subject
            to clause 16.7(b), at liberty to dispose of the Sale Shares in
            accordance with the terms of the Bona Fide Offer to the person or
            persons making that offer within 3 calendar months after the date of
            such decline.

      (b)   It will be a condition of transfer of the Sale Shares to a third
            person pursuant to clause 16.7(a) that:

            (i)   the third person enter into a Deed of Assumption under which
                  the third person agrees to be bound by this Agreement on terms
                  acceptable to the other Shareholder(s) acting reasonably; and

            (ii)  the third person is acceptable to the other Shareholder(s),
                  acting reasonably, taking into account the third person's
                  business reputation, respectability and financial stability.

16.8  Pre-emption procedure inapplicable

      The preceding provisions of this clause 16 do not apply in relation to a
      disposal of Shares where:

      (a)   all the Directors of the Companies unanimously consent in writing to
            that effect; or

      (b)   the person to whom the Shares are to be disposed is a Related Body
            Corporate of the Offering Shareholder.

16.9  Directors obligation to register

      The Directors of the Companies are bound to register any transfer of
      Shares made in accordance with this clause 16.


                                                                              34
<PAGE>

17.   STATEMENT ON SHARE CERTIFICATES

      The Shareholders will cause the Companies to endorse on each of the
      Companies' share certificates the following legend:

            "The shares to which this certificate relates are subject to and
            transferable only in accordance with the provisions of the
            Shareholders Agreement dated [         ] among AVAX Australia
            Holdings Pty Limited, Eastpac Inc., Jetona Pty Ltd and Neptunus
            International Holdings Limited."

18.   FURTHER JOINT VENTURES

18.1  Right of first refusal

      AVAX Holdings agrees to grant to NIHL Sub a right of first refusal to
      participate, on a 50% basis, with an Additional Joint Venturer in Further
      Joint Ventures in accordance with this clause 18.

18.2  Interpretation

      For the purposes of this clause 18:

      "Additional Joint Venturer" means AVAX Holdings or any Related Body
      Corporate of AVAX Holdings that becomes entitled to develop, manufacture,
      sell and/or distribute the Licensed Products in one or more of the
      Countries.

      "Countries" means the Peoples Republic of China, Thailand, Malaysia,
      Singapore and the Philippines.

      "Notice" means a notice in writing to NIHL Sub identifying the Further
      Joint Venture and annexing a copy of a joint venture agreement to be
      entered into between the Additional Joint Venturer and NIHL Sub in
      relation to the Further Joint Venture.

      "Further Joint Venture" means future joint ventures between an Additional
      Joint Venturer and a third party involving the development, manufacture,
      sale and/or distribution of the Licensed Products in one or more of the
      Countries.

18.3  Additional Joint Venturer to give Notice

      Prior to the entry by an Additional Joint Venturer into a Further Joint
      Venture with a third party, the Additional Joint Venturer must give a
      Notice to NIHL Sub. A Notice is not revocable


                                                                              35
<PAGE>

18.4  Nature of offer

      A Notice constitutes an offer by the Additional Joint Venturer to enter
      into a joint venture with NIHL Sub on the terms of the joint venture
      agreement annexed to the Notice.

18.5  Time

      A Notice must specify the period within which the offer constituted by the
      Notice may be accepted, that period being not less than 30 days. NIHL Sub
      will make a good faith effort to respond to the offer constituted by the
      Notice in less than 30 days and, if NIHL Sub fails to accept the offer
      constituted by the Notice within the time period specified in the Notice,
      NIHL Sub will be deemed to have rejected that offer.

18.6  Entry into Further Joint Venture

If    NIHL Sub accepts the offer constituted by the Notice, the Additional Joint
      Venturer and NIHL Sub must enter into the joint venture agreement in the
      form annexed to the Notice within 10 days of the acceptance of the offer
      by NIHL Sub.

18.7  Joint venture with a third party

      If the offer constituted by the Notice is rejected or deemed to be
      rejected under clause 18.5 or NIHL Sub fails to enter into the joint
      venture agreement in the form annexed to the Notice within the time period
      set out in clause 18.6, the Additional Joint Venturer will be at liberty
      to enter into a joint venture with a third party on terms no more
      favourable to the third party than those contained in the Notice within 3
      calendar months after the date of such rejection or deemed rejection.

18.8  Compliance by Additional Joint Venturer

      AVAX Holdings will procure that an Additional Joint Venturer complies with
      the provisions of this clause 18.

19.   FURTHER AVAX LICENCES

19.1  Right of first refusal

      AVAX Holdings agrees to grant to NIHL Sub a right of first refusal to be
      granted rights in the Territory in respect of any right an Additional
      Rights Licensor may acquire in respect of the sale and distribution of
      products under:

      (a)   the Rutgers Licence; and


                                                                              36
<PAGE>

      (b)   the Texas A&M Licence,

      in accordance with this clause 19.

19.2  Interpretation

      For the purposes of this clause 19:

      "Additional Rights Licensor" means AVAX Holdings or any Related Body
      Corporate of AVAX Holdings that is entitled to grant a licence in respect
      of the sale and distribution of products under the Rutgers Licence and/or
      the Texas A&M Licence (or both of them) in the Territory.

      "Notice" means a notice in writing to NIHL Sub identifying the Rights and
      annexing a copy of a licence and distribution agreement to be entered into
      between the Additional Rights Licensor and NIHL Sub in relation to the
      Rights.

      "Rights" means those rights acquired by an Additional Rights Licensor in
      respect of the sale and distribution of products in the Territory under
      the Rutgers Licence or the Texas A&M Licence (or both of them) which the
      Additional Rights Licensor proposes to license in the Territory.

      "Rutgers Licence" means the interest of AVAX Technologies in its licence
      agreements with Rutgers University and the University of Medicine and
      Dentistry of New Jersey, certain patent applications relating to a series
      of topoisomerase inhibitor compounds for the potential treatment of cancer
      and infectious diseases.

      "Texas A&M Licence" means the interest of AVAX Technologies in its licence
      agreements with Texas A&M University System, an issued US patent and
      certain patent applications relating to a series of novel anti-estrogen
      compounds for the potential treatment of cancer.

19.3  Additional Rights Licensor to give Notice

      Prior to the grant of any Rights by an Additional Rights Licensor to a
      third party, the Additional Rights Licensor must give a Notice to NIHL
      Sub. A Notice is not revocable.

19.4  Nature of offer

      A Notice constitutes an offer by the Additional Rights Licensor to license
      the Rights to NIHL Sub on the terms of the licence and distribution
      agreement annexed to the Notice.


                                                                              37
<PAGE>

19.5  Time

      A Notice must specify the period within which the offer constituted by the
      Notice may be accepted, that period being not less than 30 days. NIHL Sub
      will make a good faith effort to respond to the offer constituted by the
      Notice in less than 30 days and, if NIHL Sub fails to accept the offer
      constituted by the Notice within the time period specified in the Notice,
      NIHL Sub will be deemed to have rejected that offer.

19.6  License of the Rights

      If NIHL Sub accepts the offer constituted by the Notice, the Additional
      Rights Licensor and NIHL Sub must enter into the licence and distribution
      agreement in the form annexed to the Notice within 10 days of the
      acceptance of the offer by NIHL Sub.

19.7  License to third party

      If the offer constituted by the Notice is rejected or deemed to be
      rejected under clause 19.5 or NIHL Sub fails to enter into the licence and
      distribution agreement in the form annexed to the Notice within the time
      period set out in clause 19.6, the Additional Rights Licensor will be at
      liberty to license the Rights to a third party on terms no more favourable
      to the third party than those contained in the Notice within 3 calendar
      months after the date of such rejection or deemed rejection.

19.8  Compliance by Additional Rights Licensor

      AVAX Holdings will procure that an Additional Rights Licensor complies
      with the provisions of this clause 19.

19.9  Property of AVAX Technologies

      NIHL Sub acknowledges that the Rights are and remain the sole property of
      AVAX Technologies (or one or more of its Related Bodies Corporate), and
      NIHL Sub will not in any way question, dispute or infringe them.

20.   PUBLICITY

20.1  No announcements without consent

      Each Shareholder will not and, will procure that no member of its Group
      will, issue, give or make any announcement or other publicity concerning
      the making or the contents of this Agreement without the prior written
      consent of each other


                                                                              38
<PAGE>

      Shareholder save as required by any statutory or regulatory authority,
      including the Securities Exchange Commission and the Australian Stock
      Exchange Limited.

20.2  Procedure for approving announcements

      In the case of written announcements or other written publicity to be
      issued, given or made concerning the business of the Companies by a
      Shareholder, the Shareholder intending to make the announcement or to give
      or issue the publicity will:

      (a)   deliver a copy of the proposed announcement or publicity to each
            other Shareholder;

      (b)   give each other Shareholder a reasonable opportunity to see and
            comment on the same before issue; and

      (c)   promptly after making the announcement or issuing the publicity give
            a copy of the final version to each other Shareholder.

      Each other Shareholder's consent to the issue of a proposed announcement
      or other publicity will not be unreasonably withheld.

21.   GUARANTEE AND INDEMNITY

21.1  Guarantee

      NIHL irrevocably and unconditionally guarantees to AVAX Holdings the due
      and punctual performance by NIHL Sub and NIHL ServiceCo of the
      Obligations.

21.2  Indemnity

      NIHL as a separate, additional and primary liability hereby irrevocably
      and unconditionally agrees to indemnify AVAX Holdings and at all times
      hereafter to keep AVAX Holdings indemnified against any loss or damage
      suffered by AVAX Holdings arising out of:

      (a)   any failure by NIHL Sub or NIHL ServiceCo to duly and punctually
            perform the Obligations; or

      (b)   any obligation or liability that would otherwise form part of the
            Obligations of NIHL Sub or NIHL ServiceCo being void, voidable or
            enforceable against or irrevocable from NIHL Sub or NIHL ServiceCo
            by AVAX Holdings in full for any reason.

21.3 Principal obligation


                                                                              39
<PAGE>

      NIHL acknowledges that this guarantee and indemnity is a continuing
      security and principal obligation between NIHL and AVAX Holdings and will
      not be affected by:

      (a)   any claim which NIHL Sub or NIHL ServiceCo may have or claim to have
            against AVAX Holdings on any account; or

      (b)   any termination by NIHL, settlement of account, intervening payment,
            express or implied revocation or any other matter or thing,

      until a final discharge thereof has been given to NIHL.

21.4  Liability of NIHL absolute

      The liability of NIHL under this Agreement is absolute. It is not subject
      to the execution of any other instrument or document by any person and is
      not subject to the performance of any condition precedent or subsequent
      between or amongst any person or persons.

21.5  Payable on demand

      Unless otherwise provided, all money payable under this Agreement by NIHL
      will be paid on demand from AVAX Holdings in immediately available funds
      to the account and in the manner notified from time to time by AVAX
      Holdings to NIHL. All money received or recovered by AVAX Holdings on
      account of the Obligations of NIHL Sub or NIHL ServiceCo will be treated
      as payments in gross and may be appropriated in such manner and at such
      times as AVAX Holdings determines in its absolute discretion.

21.6  Reimbursement of expenses

      NIHL will on demand reimburse AVAX Holdings for, and keep AVAX Holdings
      indemnified against, all expenses (including legal fees, costs and
      disbursements on a solicitor/own client basis) incurred by AVAX Holdings
      in connection with the enforcement, attempted enforcement or preservation
      of any rights under this guarantee.

21.7  No prior demand on NIHL Sub or NIHL ServiceCo

      AVAX Holdings will not be required to make any claim or demand on NIHL Sub
      or NIHL ServiceCo or to enforce any right, power or remedy against NIHL
      Sub or NIHL ServiceCo before making any demand or claim upon NIHL under
      this Agreement.


                                                                              40
<PAGE>

21.8  NIHL's further acknowledgements

      NIHL further acknowledges that its liability will not be impaired by:

      (a)   AVAX Holdings granting time or other indulgence to or making any
            composition with NIHL Sub, NIHL ServiceCo or any other guarantor;

      (b)   NIHL Sub, NIHL ServiceCo or any other guarantor being a corporate
            body being wound up or passing a resolution for its liquidation, or
            by the appointment of a receiver, provisional liquidator or official
            manager thereof;

      (c)   AVAX Holdings having previously obtained, or at any time after the
            date of this Agreement obtaining, any further or other covenant or
            security or guarantee in respect of the Obligations of NIHL Sub or
            NIHL ServiceCo from NIHL Sub, NIHL ServiceCo or from any other
            person or corporation;

      (d)   AVAX Holdings forbearing or neglecting to exercise any remedy or
            right it may have at any time in the future for the enforcement of
            the Obligations of NIHL Sub or NIHL ServiceCo or this guarantee and
            indemnity;

      (e)   the promises, undertakings or agreements of NIHL Sub or NIHL
            ServiceCo in this Agreement, or by any other instrument or
            transaction being or becoming illegal, invalid, void or
            unenforceable by reason of any past, present or future statute,
            matter, act, or omission by any person;

      (f)   the absence of any notice to NIHL of default by NIHL Sub or NIHL
            ServiceCo, or by any other guarantor;

      (g)   the existence now, or at any future time, of any legal disability in
            NIHL Sub or NIHL ServiceCo or NIHL;

      (h)   AVAX Holdings waiving any breach or default by NIHL Sub or NIHL
            ServiceCo or NIHL; or

      (i)   NIHL Sub, NIHL ServiceCo, NIHL or any other guarantor, being a
            natural person, becoming bankrupt, or entering into any composition
            or arrangement with his creditors, or assigning his estate or any
            part thereof for the benefit of creditors, or becoming of unsound
            mind, or dying.

21.9  NIHL's consent etc. unnecessary


                                                                              41
<PAGE>

      NIHL acknowledges that nothing in this Agreement will be construed as a
      requirement that NIHL consent to, or be made aware of, any transaction
      between AVAX Holdings and NIHL Sub or NIHL ServiceCo, including any
      variation, release or compromise of the Obligations of NIHL Sub or NIHL
      ServiceCo, or any document in which they are set forth.

21.10 No reduction if payment is a voidable preference

      NIHL acknowledges that no payment will operate to discharge or reduce
      NIHL's liability if such payment is voidable as a preference under any law
      relating to bankruptcy or the winding up of companies, and no grant of
      discharge or release consequent upon such a payment will discharge the
      liability of NIHL hereunder.

22.   TERM

      This Agreement will terminate automatically if one Shareholder acquires
      all of those Shares held by all other Shareholders pursuant to this
      Agreement.

23.   NOTICES

      Any communication under or in connection with this Agreement:

      (a)   must be in writing;

      (b)   must be addressed as shown below:

            To AVAX Holdings

                  4520 Main Street
                  Suite 930
                  Kansas City, Missouri 64111
                  United States of America

                  Fax number:      (816) 960 1334
                  Attention:               Mr David Tousley

            with a copy to:

                  Clayton Utz
                  Levels 27-35
                  No. 1 O'Connell Street
                  Sydney  NSW  2000
                  Australia


                                                                              42
<PAGE>

                  Fax number:      61 2 9251 7832
                  Attention:               Graham Taylor

           and

                  Shook, Hardy & Bacon LLP
                  1200 Main Street
                  Kansas City, Missouri 64105
                  United States of America

                  Fax number:      (816) 421 5547
                  Attention:       Kevin R Sweeney

            To NIHL Sub

                  Richard Hill & Associates
                  Level 8
                  157-159 Walker Street
                  North Sydney  NSW  2060
                  Australia

                  Fax number:      61 2 9957 5948
                  Attention:       Richard Hill

            with a copy to:

                  Herbert Geer & Rundle
                  Level 21
                  385 Bourke Street
                  Melbourne  VIC  3000
                  Australia

                  Fax number:      61 3 9641 8700
                  Attention:       Ian McCubbin

            To NIHL ServiceCo

                  Richard Hill & Associates
                  Level 8
                  157-159 Walker Street
                  North Sydney  NSW  2060
                  Australia

                  Fax number:      61 2 9957 5948


                                                                              43
<PAGE>

                  Attention:       Richard Hill

            with a copy to:

                  Herbert Geer & Rundle
                  Level 21
                  385 Bourke Street
                  Melbourne  VIC  3000
                  Australia

                  Fax number:      61 3 9641 8700
                  Attention:       Ian McCubbin

            To NIHL

                  Richard Hill & Associates
                  Level 8
                  157-159 Walker Street
                  North Sydney  NSW  2060
                  Australia

                  Fax number:      61 2 9957 5948
                  Attention:       Richard Hill

            with a copy to:

                  Herbert Geer & Rundle
                  Level 21
                  385 Bourke Street
                  Melbourne  VIC  3000
                  Australia

                  Fax number:      61 3 9641 8700
                  Attention:       Ian McCubbin

            (or as otherwise notified by that party to the other parties from
            time to time);

      (c)   must be signed by the party making the communication or (on its
            behalf) by the solicitor for, or by any attorney, director,
            secretary, or authorised agent of, that party;

      (d)   must be delivered or posted by prepaid post to the address, or sent
            by fax to the number, of the addressee, in accordance with clause
            23(b); and


                                                                              44
<PAGE>

      (e)   will be deemed to be received by the addressee:

                  (i)   (in the case of prepaid post) on the third Business Day
                        after the date of posting to an address within
                        Australia, and on the fifth Business Day after the date
                        of posting to an address outside Australia;

                  (ii)  (in the case of fax) at the local time (in the place of
                        receipt of that fax) which then equates to the time at
                        which that fax is sent as shown on the transmission
                        report which is produced by the machine from which that
                        fax is sent and which confirms transmission of that fax
                        in its entirety, unless that local time is a non
                        Business Day, or is after 5.00 pm on a Business Day,
                        when that communication will be deemed to be received at
                        9.00 am on the next Business Day; and

                  (iii) (in the case of delivery by hand) on delivery at the
                        address of the addressee as provided in clause 23(b),
                        unless that delivery is made on a non Business Day, or
                        after 5.00 pm on a Business Day, when that communication
                        will be deemed to be received at 9.00 am on the next
                        Business Day.

24.   GOVERNING LAW AND JURISDICTION

24.1  This Agreement will be construed in accordance with and will be governed
      by the laws in force in the State of Missouri in the United States of
      America without giving effect to the choice-of-law rules thereof.

24.2  This Agreement will be deemed to have been made and executed in Kansas
      City, Missouri, United States of America.

25.   ARBITRATION

25.1  Any dispute, controversy or claim arising out of or relating to this
      Agreement or a breach hereof will be exclusively and finally resolved by
      arbitration in accordance with the International Arbitration Rules of the
      American Arbitration Association. Unless otherwise agreed in writing by
      the parties hereto, the arbitral panel will consist of one (1) arbitrator
      to be appointed by the American Arbitration Association within sixty (60)
      calendar days after any such dispute, controversy or claim has been
      referred to arbitration hereunder.

25.2  The arbitration proceedings will be in the English language and will be
      held in Kansas City, Missouri, United States of America. The arbitral
      award will be in writing in English, will not be contrary to the governing
      law of this Agreement, will not award punitive, consequential or exemplary
      damages, will provide reasons for the award, and will be final and binding
      upon the parties hereto.


                                                                              45
<PAGE>

25.3  Each party waives any right it may have by statute, treaty or law to
      contest the jurisdiction or venue of any court or service made pursuant to
      clause 23 hereof in an action or proceeding to enforce an arbitral award,
      including without limitation any right under the Foreign Sovereign
      Immunities Act of the United States, the Hague Convention on the Service
      Abroad of Judicial and Extrajudicial Documents in Civil or Commercial
      Matters and the Hague Convention on the Taking of Evidence Abroad in Civil
      or Commercial Matters, and each party agrees that the validity of arbitral
      awards will only be challenged in accordance with Article V of the United
      Nations Convention on the Recognition and Enforcement of Foreign Arbitral
      Awards.

25.4  The provisions of this clause 25 will survive any expiration or
      termination of this Agreement, and will be severable and binding on the
      parties hereto, notwithstanding that any other provision of this Agreement
      may be held or declared to be invalid, illegal or unenforceable.

26.   MISCELLANEOUS

26.1  Entire agreement

      To the extent permitted by law, in relation to the subject matter of this
      Agreement, this Agreement:

      (a)   embodies the entire understanding of the parties, and constitutes
            the entire terms agreed on between the parties; and

      (b)   supersedes any prior written or other agreement between the parties.

26.2  Amendments

      This Agreement may only be varied by a document signed by or on behalf of
      each of the parties.

26.3  Assignment

      A party cannot assign, novate or otherwise transfer any of its rights or
      obligations under this Agreement without the prior written consent of each
      other party.

26.4  Counterparts

      This Agreement may be executed in any number of counterparts and by the
      parties on separate counterparts. Each counterpart constitutes an original
      of this Agreement, all of which together constitute one agreement.


                                                                              46
<PAGE>

26.5  No representation or reliance

      (a)   Each party acknowledges that no party (nor any person acting on its
            behalf) has made any representation or other inducement to it to
            enter into this Agreement, except for representations or inducements
            expressly set out in this Agreement.

      (b)   Each party acknowledges and confirms that it does not enter into
            this Agreement in reliance on any representation or other inducement
            by or on behalf of any other party, except for any representation or
            inducement expressly set out in this Agreement.

26.6  Waiver

      (a)   Failure to exercise or enforce or a delay in exercising or enforcing
            or the partial exercise or enforcement of any right, power or remedy
            provided by law or under this Agreement by any party will not in any
            way preclude, or operate as a waiver of, any exercise or
            enforcement, or further exercise or enforcement of that or any other
            right, power or remedy provided by law or under this Agreement.

      (b)   Any waiver or consent given by any party under this Agreement will
            only be effective and binding on that party if it is given or
            confirmed in writing by that party.

      (c)   No waiver of a breach of any term of this Agreement will operate as
            a waiver of another breach of that term or of a breach of any other
            term of this Agreement.

26.7  Further acts

      Each party will promptly do and perform all further acts and execute and
      deliver all further documents (in form and content reasonably satisfactory
      to that party) required by law or reasonably requested by any other party
      to give effect to this Agreement.

26.8  Indemnities

      Each indemnity in this Agreement, if any, is a continuing obligation,
      separate and independent from the other obligations of the parties, and
      survives termination, completion or expiration of this Agreement.


                                                                              47
<PAGE>

      It is not necessary for a party to incur expense or to make any payment
      before enforcing a right of indemnity conferred by this Agreement.

26.9  No partnership or agency

      Nothing in this Agreement will create or constitute or be deemed to create
      or constitute a partnership between the Shareholders for the purposes of
      the Partnership Act 1892 (NSW), the Income Tax Assessment Act or any other
      law of any jurisdiction and except as specifically provided herein neither
      Shareholder will act or represent or hold itself out as having authority
      to act as agent of or in any way bind or commit the other Shareholder to
      any obligation.

26.10 Rights and obligations are several

      The rights, duties, obligations and liabilities of the Shareholders will
      be several and not joint or collective and nothing herein contained will
      be construed as creating a partnership of any kind or an association or a
      trust each Shareholder being individually responsible for only its own
      obligations as set out in this Agreement.

26.11 Severance

      If any provision of this Agreement or part thereof is held illegal,
      unenforceable or otherwise invalid that provision or part will be deemed
      to be severed from this Agreement and the remainder of this Agreement will
      continue in effect.

26.12 Costs and Stamp Duty

      Each of the parties to this Agreement will be responsible for its own
      costs and expenses of and in connection with the negotiation, preparation,
      execution, stamping, registration and completion of this Agreement and of
      any document contemplated by this Agreement. Any stamp duty payable on
      this Agreement will be borne in equal proportions by AVAX Holdings and
      NIHL Sub.

26.13 Force majeure

      No failure or omission to carry out or observe any term of this Agreement
      will give rise to a claim by any party against another or result in a
      breach of this Agreement if such failure or omission arises by reason of
      delay or inability to perform caused by war, whether declared or not,
      civil rebellion, strike, fire, storm or other severe action of the
      elements, accident, government or statutory restriction or from other
      similar causes which are unavoidable or beyond the reasonable control of
      the defaulting party.

26.14 No exclusion of rights


                                                                              48
<PAGE>

      Except as expressly provided herein, the rights, powers or remedies
      provided in this Agreement are cumulative with and not exclusive of any
      rights, powers or remedies provided independently of this Agreement.

26.15 Application of legislation

      Unless application is mandatory by law, no legislation, proclamation,
      order, regulation or moratorium whether present or future shall apply to
      this Agreement so as to extinguish, impair, delay or otherwise alter the
      rights, powers or remedies of any of the parties.

26.16 Powers of attorney

      In the event that this Agreement is executed under power of attorney, each
      of the Attorneys executing this Agreement hereby warrants that he has at
      the time of executing this Agreement no notice of revocation of the power
      of attorney under the authority of which he executes this Agreement.

26.17 Withholding of moneys

      The parties acknowledge that AVAX Australia and AVAX Manufacturing are
      entitled to withhold from any Shareholder any moneys they are required to
      withhold under Australian law and to remit those moneys to the appropriate
      authority.

SIGNED as an agreement.

EXECUTED by AVAX AUSTRALIA HOLDINGS   )
PTY LIMITED, ACN 089 164 090 by or    )
in the presence of:                   )

/s/ Jeff Jonas                             /s/ David L. Tousley
- ------------------------------------       ------------------------------------
(Signature of Secretary/Director)          (Signature of Director)

          Jeff Jonas                                David L. Tousley
- ------------------------------------       ------------------------------------
(Name of Secretary/Director in Full)       (Name of Director in Full)

THE COMMON SEAL of EASTPAC INC. was   )
affixed by the authority of the       )
Board of Directors in the presence of:)
                                      )

                                                                              49
<PAGE>

/s/ Richard Langley Stewart Hill           /s/ Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
Authorised Signatory                       (Signature of Director)
(Secretary/Director)


    Richard Langley Stewart Hill                    Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
(Name of Secretary/Director in Full)       (Name of Director in Full)

EXECUTED by JETONA PTY LTD,              )
ACN 089 914 152 by or in the presence of:)
                                         )
                                         )


/s/ Richard Langley Stewart Hill           /s/ Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
(Signature of Secretary/Director)          (Signature of Director)


    Richard Langley Stewart Hill                    Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
(Name of Secretary/Director in Full)       (Name of Director in Full)


                                                                              50
<PAGE>

THE COMMON SEAL of NEPTUNUS           )
INTERNATIONAL HOLDINGS LIMITED,       )
ARBN 065 824 302 was affixed by the   )
authority of the Board of Directors
in the presence of:


/s/ Richard Langley Stewart Hill           /s/ Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
Authorised Signatory (Secretary/Director)  Authorised Signatory (Director)


    Richard Langley Stewart Hill                    Hudson Hak Fun Chen
- -------------------------------------      ------------------------------------
(Name of Secretary/Director in Full)       (Name of Director in Full)


                                                                              51


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