AVAX TECHNOLOGIES INC
4, 1999-12-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

|_|  Check this box if no longer subject to Section 16. Form 4 or Form 5
     obligations may continue. See Instruction 1(b).

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1. Name and Address of Reporting Person*

   Yankee, Ernest W.
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   (Last)               (First)                 (Middle)


11508 Cedar Street
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                                    (Street)


Leawood, KS 66211
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   (City)               (State)                 (Zip)


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2. Issuer Name and Ticker or Trading Symbol

   AVAX Technologies, Inc. (AVXT)
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3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)


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4. Statement for Month/Year

   December, 1999
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5. If Amendment, Date of Original (Month/Year)


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6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   |_|   Director                             |_|   10% Owner
   |X|   Officer (give title below)           |_|   Other (specify below)

         Executive Vice President
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7. Individual or Joint/Group Filing (Check Applicable Line)

   |X|  Form filed by one Reporting Person
   |_|  Form filed by more than one Reporting Person

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* If the Form is filed by more than one Reporting Person, see Instruction
  4(b)(v).
<PAGE>

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           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                     6.
                                                      4.                              5.             Owner-
                                                      Securities Acquired (A) or      Amount of      ship
                                         3.           Disposed of (D)                 Securities     Form:     7.
                                         Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                           2.            Code         ----------------------------    Owned at End   (D) or    Indirect
1.                         Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security          Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                 (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                        <C>            <C>      <C>    <C>         <C>    <C>       <C>           <C>       <C>
- ------------------------------------------------------------------------------------------------------------------------------------
N/A
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====================================================================================================================================
</TABLE>

Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.


                                   Page 1 of 2
<PAGE>

FORM 4 (continued)

Table       II -- Derivative Securities Acquired, Disposed of, or Beneficially
            Owned (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                          9.        10.
                                                                                                          Number    Owner-
                                                                                                          of        ship
                  2.                                                                                      Deriv-    Form of
                  Conver-                    5.                                7.                         ative     Deriv-   11.
                  sion                       Number of                         Title and Amount           Secur-    ative    Nature
                  of                         Derivative    6.                  of Underlying     8.       ities     Secur-   of
                  Exer-             4.       Securities    Date                Securities        Price    Bene-     ity:     In-
                  cise     3.       Trans-   Acquired (A)  Exercisable and     (Instr. 3 and 4)  of       ficially  Direct   direct
                  Price    Trans-   action   or Disposed   Expiration Date     ----------------  Deriv-   Owned     (D) or   Bene-
1.                of       action   Code     of(D)         (Month/Day/Year)              Amount  ative    at End    In-      ficial
Title of          Deriv-   Date     (Instr.  (Instr. 3,    ----------------              or      Secur-   of        direct   Owner-
Derivative        ative    (Month/  8)       4 and 5)      Date       Expira-            Number  ity      Month     (I)      ship
Security          Secur-   Day/     ------   ------------  Exer-      tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)        ity      Year)    Code V    (A)   (D)    cisable    Date     Title     Shares  5)       4)        4)       4)
- ----------------------------------------------------------------------------------------------------------------------------------
<S>               <C>      <C>      <C>  <C>  <C>   <C>    <C>         <C>       <C>     <C>     <C>      <C>       <C>      <C>
- ----------------------------------------------------------------------------------------------------------------------------------
Statutory Stock   $2.75    11/17/99 A(2)      48,386       11/17/99(3) 11/17/06  Common  48,386           283,386   D
Option(1)                                                                        Stock
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====================================================================================================================================
</TABLE>
Explanation of Responses:

(1) Represents a Right to Purchase.
(2) Acquired through Authorization of the Board of Directors.
(3) The Option vests in 16 equal installments commencing on November 17, 1999
and continuing at a rate of 1/16 per calendar quarter. This Option terminates on
November 17, 2006.

- --------
**  Intentional misstatements or omissions of facts constitute Federal Criminal
    Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).


/s/ Ernest W. Yankee                                             12-9-99
- ---------------------------------------------            -----------------------
** Signature of Reporting Person                                  Date

Note: File three copies of this Form, one of which must be manually signed. If
      space provided is insufficient, see Instruction 6 for procedure.


                                   Page 2 of 2



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