VYSIS INC
S-8, 1998-03-06
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

   As filed with the Securities and Exchange Commission on  March 6, 1998
                                                              File No. 333-

==============================================================================

                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549
                                  ------------------

                                       FORM S-8
                                REGISTRATION STATEMENT
                                        Under
                              THE SECURITIES ACT OF 1933

                                  ------------------

                                     VYSIS, INC.
                (Exact Name of Registrant as Specified in its Charter)

           Delaware                               36-3803405
(State or Other Jurisdiction         (I.R.S. Employer Identification No.)
of Incorporation or Organization)

       3100 Woodcreek Drive
       Downers Grove, Illinois                      60515
(Address of Principal Executive Offices)         (Zip Code)

                                     VYSIS, INC.
                              1996 STOCK INCENTIVE PLAN
                               (Full Title of the Plan)

                                   John L. Bishop
                       President and Chief Executive Officer
                                    Vysis, Inc.
                                3100 Woodcreek Drive
                            Downers Grove, Ilinois 60515
                      (Name and Address of Agent For Service)

                                    (630) 271-7000
            (Telephone Number, Including Area Code, of Agent For Service)

                                  ------------------


                           CALCULATION OF REGISTRATION FEE
==============================================================================
<TABLE>
<CAPTION>
                                         PROPOSED      PROPOSED
                                         MAXIMUM       MAXIMUM      AMOUNT
                                         OFFERING      AGGREGATE      OF
   TITLE OF SECURITIES  AMOUNT TO BE     PRICE PER     OFFERING    REGISTRA-
    TO BE REGISTERED    REGISTERED(1)    SHARE(2)      PRICE(2)    TION FEE
<S>                     <C>              <C>          <C>          <C>
Common Stock, $0.001
par value . . . . . .      971,826         $1.61      $1,569,217     $463
==============================================================================
</TABLE>
(1)  Also registered hereby are an indeterminate number of additional shares
     that may become issuable pursuant to the anti-dilution provisions of the
     plan.
(2)  In accordance with Rule 457(h)(1), the offering price of shares currently
     subject to options was computed upon the basis of the exercise price. 
     41,305 shares have an exercise price of $12.00,  33,577 shares have an
     exercise price of $6.85, 127,698 shares have an exercise price of $2.74,
     37,899 shares have an exercise price of $1.34 and 726,005 shares have an
     exercise price of $.53.  The offering price for the remaining 5,342  shares
     for which options have not been awarded was computed upon the basis of the
     average of the high and low sale prices of the shares reported on the
     NASDAQ National Market System on March 2, 1998, which was $10.88.

==============================================================================
<PAGE>

                                       PART II


                               INFORMATION REQUIRED IN
                              THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

     The following documents, which have been filed by Vysis, Inc., a 
corporation organized under the laws of the State of Delaware (the "Company" 
or the "Registrant"), with the Securities and Exchange Commission (the 
"Commission") pursuant to the Securities Act of 1933, as amended (the 
"Securities Act"), and the Securities Exchange Act of 1934, as amended (the 
"Exchange Act"), are incorporated by reference herein and shall be deemed to 
be a part hereof:

     (a)  The Company's Prospectus dated February 4, 1998, filed with the
          Commission pursuant to Rule 424(b) under the Securities Act.  (File
          No. 333-38109)

     (b)  The description of the Company's common stock, par value $.001 per
          share (the "Common Stock") under the caption "Description of
          Registrant's Securities to be Registered" included in the Company's
          Registration Statement on Form 8-A.  (Exchange Act File No. 000-23659)

     All documents subsequently filed by the Company pursuant to Sections 
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a 
post-effective amendment which indicates that all securities offered have 
been sold or which deregisters all securities then remaining unsold, shall be 
deemed to be incorporated herein by reference and shall be deemed a part 
hereof from the date of filing of such documents.

ITEM 4.  DESCRIPTION OF SECURITIES.

     Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

     The validity of the shares of Common Stock offered hereby will be passed 
upon for the Company by William E. Murray, General Counsel of the Company.  
As of March 4, 1998, Mr. Murray owned options to purchase  16,424 shares of 
Common Stock of the Company.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS. 

     (a)  The Delaware General Corporation Law (the "Delaware GCL") (Section 
145) gives Delaware corporations broad powers to indemnify their present and 
former directors and officers and those of affiliated corporations against 
expenses incurred in the defense of any lawsuit to which they are made 
parties by reason of being or having been such directors or officers, subject 
to specified conditions and exclusions, gives a director or officer who 
successfully defends an action the right to be so indemnified, and authorizes 
the Company to buy directors' and officers' liability insurance.  Such 
indemnification is not exclusive of any other rights to which those 
indemnified may be entitled under any by-laws, agreement, vote of 
stockholders or otherwise.

      (b)  Article 10 of the Certificate of Incorporation of the Company and 
Article 6 of the Company's By-laws provides for indemnification of directors 
and officers to the fullest extent permitted by law. 

     The Company maintains directors and officers liability insurance for the 
benefit of its directors and certain of its officers.

                                       II-1
<PAGE>

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

     Not applicable.

ITEM 8.  EXHIBITS.

     See Exhibit Index which is incorporated herein by reference.

ITEM 9.  UNDERTAKINGS.

     The undersigned Registrant hereby undertakes:

     1.   To file, during any period in which offers or sales are being made, a
          post-effective amendment to this registration statement:

          (i)  To include any prospectus required by section 10(a)(3) of the
               Securities Act;

         (ii)  To reflect in the prospectus any facts or events arising after
               the effective date of the registration statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in the registration statement. 
               Notwithstanding the foregoing, any increase or decrease in volume
               of securities offered (if the total dollar value of securities
               offered would not exceed that which was registered) and any
               deviation from the low or high and of the estimated maximum
               offering range may be reflected in the form of prospectus filed
               with the Commission pursuant to Rule 424(b) if, in the aggregate,
               the changes in volume and price represent no more than 20 percent
               change in the maximum aggregate offering price set forth in the
               "Calculation of Registration Fee" table in the effective
               registration statement;

        (iii)  To include any material information with respect to the plan
               of distribution not previously disclosed in the registration
               statement or any material change to such information in the
               registration statement;

               PROVIDED, HOWEVER, that paragraphs (1)(i) and (1)(ii) do not
               apply if the registration statement is on Form S-3 or  Form S-8,
               and the information required to be included in a post-effective
               amendment by those paragraphs is contained in periodic reports
               filed with or furnished to the Commission by the Registrant
               pursuant to section 13 or section 15(d) of the Exchange Act that
               are incorporated by reference in the registration statement.

     2.   That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial bona fide offering thereof.

     3.   To remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering.

     The undersigned Registrant hereby undertakes that, for purposes of 
determining any liability under the Securities Act, each filing of the 
Registrant's annual report pursuant to section 13(a) or section 15(d) of the 
Exchange Act (and, where applicable, each filing of an employee benefit 
plan's annual report pursuant to section 15(d) of the Exchange Act) that is 
incorporated by reference in the registration statement shall be deemed to be 
a new registration

                                       II-2
<PAGE>

statement relating to the securities offered therein, and the offering of 
such securities at that time shall be deemed to be the initial bona fide 
offering thereof.

     Insofar as indemnification for liabilities arising under the Securities 
Act may be permitted to directors, officers and controlling persons of the 
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant 
has been advised that in the opinion of the Commission such indemnification 
is against public policy as expressed in the Securities Act and is, 
therefore, unenforceable.  In the event that a claim for indemnification 
against such liabilities (other than the payment by the Registrant of 
expenses incurred or paid by a director, officer or controlling person of the 
Registrant in the successful defense of any action, suit or proceeding) is 
asserted by such director, officer or controlling person in connection with 
the securities being registered, the Registrant will, unless in the opinion 
of its counsel the matter has been settled by controlling precedent, submit 
to a court of appropriate jurisdiction the question whether such 
indemnification by it is against public policy as expressed in the Securities 
Act and will be governed by the final adjudication of such issue.

                                       II-3
<PAGE>
                                  POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each of the undersigned directors 
and officers of Vysis, Inc. hereby constitutes and appoints John L. Bishop, 
James J. Habschmidt and William E. Murray, and each of them, severally, as 
his true and lawful attorney-in-fact and agent, for him and in his name, 
place and stead, in any and all capacities, with full power to act alone, to 
sign any and all amendments to this registration statement, and to file each 
such amendment to this registration statement with all exhibits thereto, and 
any and all documents in connection therewith, with the Securities and 
Exchange Commission, hereby granting unto said attorney-in-fact and agent 
full power and authority to do and perform any and all acts and things 
requisite and necessary to be done in and about the premises, as fully and to 
all intents and purposes as he might or could do in person, hereby ratifying 
and confirming all that said attorney-in-fact and agent may lawfully do or 
cause to be done by virtue hereof.

                                       II-4
<PAGE>
                                      SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in Downers Grove, Illinois, on the 27th day of 
February, 1998.

                                   VYSIS, INC.


                                   By:   /s/ John L. Bishop
                                      ----------------------------------------
                                      Name: John L. Bishop
                                      Title:  President and Chief Executive
                                               Officer

     Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed below by the following persons in the 
capacities and on the date indicated.

          NAME           TITLE (CAPACITY)                      DATE


/s/ John L. Bishop        President and Chief Executive
- ----------------------    Officer and Director                 February 27, 1998
John L. Bishop            (Principal Executive Officer and
                          Director)

/s/ James J. Habschmidt   Vice President of Finance and
- -----------------------   Chief Financial Officer              February 27, 1998
James J. Habschmidt       (Principal Financial and
                          Accounting Officer)

/s/ William M. Bartlett   Director                             February 27, 1998
- ----------------------
William M. Bartlett

/s/ Robert C. Carr        Director                             February 27, 1998
- ----------------------
Robert C. Carr

/s/ Kenneth L. Melmon     Director                             February 19, 1998
- ----------------------
Kenneth L. Melmon

/s/ Walter R. Quanstrom   Director                             February 27, 1998
- ----------------------
Walter R. Quanstrom

/s/ Frank J. Sroka        Director                             February 23, 1998
- ----------------------
Frank J. Sroka

/s/ Richard C. Williams   Director                             February 20, 1998
- ----------------------
Richard C. Williams

                                       II-5
<PAGE>

                                    EXHIBIT INDEX


EXHIBIT
NUMBER              DESCRIPTION OF EXHIBIT

4.1  Certificate of Incorporation of the Registrant (Incorporated by reference
     to Exhibit 3.1.1 to 3.1.8 to the Registrant's Registration Statement on
     Form S-1 (File No. 333-38109)) 

4.2  By-Laws of the Registrant, as amended (Incorporated by reference to
     Exhibit 3.2 to the Registrant's Registration Statement on Form S-1 
     (File No. 333-38109))
 
4.3  Specimen certificate evidencing the Common Stock of the Registrant
     (Incorporated by reference to Exhibit 4.1 to the Registrant's Registration
     Statement on Form S-1 (File No. 333-38109)) 

4.4  The 1996 Stock Incentive Plan of the Registrant (Incorporated by reference
     to Exhibit 10.1 to the Registrant's Registration Statement on Form S-1
     (File No. 333-38109))

5.1  Opinion of William E. Murray regarding the validity of the offered
     securities 

23.1 Consent of William E. Murrray (appears in Exhibit 5.1)

23.2 Consent of Independent Accountants

24.1 Power of Attorney (appears on the page preceding the signature page of this
     Registration Statement)



<PAGE>

                                                           EXHIBIT 5.1

                              [VYSIS LETTERHEAD]


March 6, 1998


Vysis, Inc.
3100 Woodcreek Drive
Downers Grove, IL 60515

VYSIS, INC. REGISTRATION STATEMENT ON FORM S-8

Dear Sirs:

I have represented Vysis, Inc., a Delaware corporation (the "Company"), in 
connection with the registration of 971,826 shares of common stock, $0.001 
par value per share, of the Company (the "Shares").

In connection with my representation, I have examined the corporate records 
of the Company, including its Certificate of Incorporation and all amendments 
thereto, its Bylaws, and other corporate records and documents and have made 
such other examinations as I consider necessary to render this opinion. Based 
upon the foregoing, it is my opinion that:

     1.   The Company is a corporation duly organized and validly existing
          in good standing under the laws of the State of Delaware; and

     2.   The Shares are legally authorized and, upon receipt by the Company 
          of the purchase price therefor, will be legally issued and 
          outstanding, fully paid and nonassessable.

I consent to the filing of this opinion as an exhibit to the Registration 
Statement referred to above and to all references to the undersigned in such 
Registration Statement.

Sincerely yours,




/s/ William E. Murray
- ---------------------------------
William E. Murray
General Counsel & Secretary
Vysis, Inc.

WEM/lbh


<PAGE>

                                                           EXHIBIT 23.2



                     CONSENT OF INDEPENDENT ACCOUNTANTS


We hereby consent to the incorporation by reference in this Registration 
Statement on Form S-8 of our report dated November 21, 1997 relating to the 
consolidated financial statements of Vysis, Inc., which appears on page F-2 
of the Prospectus dated February 4, 1998 relating to the Registration 
Statement on Form S-1 (No. 333-38109) of Vysis, Inc. We also consent to the 
application of such report to the Financial Statement Schedule for the three 
years ended December 31, 1996 and the nine months ended September 30, 1997 
listed under Item 16(b) of the Registration Statement on Form S-1 (No. 
333-38109) when such schedule is read in conjunction with the consolidated 
financial statements referred to in our report. The audits referred to in 
such report also include this schedule.




PRICE WATERHOUSE LLP



Chicago, Illinois
March 6, 1998





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