VYSIS INC
S-8, 2000-03-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

     As filed with the Securities and Exchange Commission on March 30, 2000
                                                                   File No. 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                               -----------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933

                               -----------------

                                   VYSIS, INC.
             (Exact Name of Registrant as Specified in its Charter)

               Delaware                                  36-3803405
      State or Other Jurisdiction           (I.R.S. Employer Identification No.)
   of Incorporation or Organization)

        3100 Woodcreek Drive
       Downers Grove, Illinois                             60515
(Address of Principal Executive Offices)                 (Zip Code)


                                   VYSIS, INC.

                    1999 Outside Directors Stock Option Plan
                    1998 Outside Director Stock Option Grants
                            (Full Title of the Plans)

                                 John L. Bishop
                      President and Chief Executive Officer
                                   Vysis, Inc.
                              3100 Woodcreek Drive
                          Downers Grove, Illinois 60515
                     (Name and Address of Agent For Service)

                                 (630) 271-7000
          (Telephone Number, Including Area Code, of Agent For Service)

                               -----------------

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
- ------------------------------------ --------------------- ------------------- --------------------- ---------------
                                                            PROPOSED MAXIMUM     PROPOSED MAXIMUM      AMOUNT OF
        TITLE OF SECURITIES              AMOUNT TO BE        OFFERING PRICE     AGGREGATE OFFERING    REGISTRATION
          TO BE REGISTERED              REGISTERED(1)         PER SHARE(2)           PRICE(2)             FEE
- ------------------------------------ --------------------- ------------------- --------------------- ---------------
<S>                                  <C>                   <C>                 <C>                   <C>
Common Stock, $0.001 par value              115,000            $10.77               $1,238,550            $327
- ------------------------------------ --------------------- ------------------- --------------------- ---------------
</TABLE>

(1)      Also registered hereby are an indeterminate number of additional shares
         that may become issuable pursuant to the anti-dilution provisions of
         the plan.

(2)      In accordance with Rule 457(h)(1), the offering price for the 30,000
         shares currently subject to options was computed based upon the
         weighted average exercise price of $4.675 per share; the offering price
         of the remaining 85,000 shares for which options have not been awarded
         was computed upon the basis of the average of the high and low sale
         prices of the shares reported on the NASDAQ National Market System on
         March 23, 2000, which was $12.92.


<PAGE>


                                     PART II

                             INFORMATION REQUIRED IN
                           THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

        The following documents, which have been filed by Vysis, Inc., a
corporation organized under the laws of the State of Delaware (the "Company" or
the "Registrant"), with the Securities and Exchange Commission (the
"Commission") pursuant to the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), are incorporated by reference herein and shall be deemed to be
a part hereof:

         (a)      The Company=s Annual Report on Form 10-K for the fiscal year
                  ended December 31, 1999, filed with the Commission pursuant to
                  Section 13(a) under the Exchange Act. (Exchange Act File No.
                  000-23659)

         (b)      The description of the Company's common stock, par value $.001
                  per share (the "Common Stock") under the caption "Description
                  of Registrant=s Securities to be Registered" included in the
                  Company's Registration Statement on Form 8-A. (Exchange Act
                  File No. 000-23659)

         All documents subsequently filed by the Company pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, shall be deemed
to be incorporated herein by reference and shall be deemed a part hereof from
the date of filing of such documents.

ITEM 4.  DESCRIPTION OF SECURITIES.

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         The validity of the shares of Common Stock offered hereby will be
passed upon for the Company by William E. Murray, General Counsel of the
Company. As of March 24, 2000, Mr. Murray owned options to purchase 91,424
shares of Common Stock of the Company.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         (a) The Delaware General Corporation Law (Section 145) gives Delaware
corporations broad powers to indemnify their present and former directors and
officers and those of affiliated corporations against expenses incurred in the
defense of any lawsuit to which they are made parties by reason of being or
having been such directors or officers, subject to specified conditions and
exclusions, gives a director or officer who successfully defends an action the
right to be so indemnified, and authorizes the Company to buy directors' and
officers' liability insurance. Such indemnification is not exclusive of any
other rights to which those indemnified may be entitled under any by-laws,
agreement, vote of stockholders or otherwise.

         (b) Article 10 of the Certificate of Incorporation of the Company and
Article 6 of the Company's By-laws provides for indemnification of directors and
officers to the fullest extent permitted by law.

         The Company maintains directors and officers liability insurance for
the benefit of its directors and certain of its officers.


                                      II-1
<PAGE>


ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

ITEM 8.  EXHIBITS.

         See Exhibit Index which is incorporated herein by reference.

ITEM 9.  UNDERTAKINGS.

         The undersigned Registrant hereby undertakes:

         1.       To file, during any period in which offers or sales are being
                  made, a post-effective amendment to this registration
                  statement:

                  (i)      To include any prospectus required by section
                           10(a)(3) of the Securities Act of 1933, as amended
                           (the "Securities Act");

                  (ii)     To reflect in the prospectus any facts or events
                           arising after the effective date of the registration
                           statement (or the most recent post-effective
                           amendment thereof) which, individually or in the
                           aggregate, represent a fundamental change in the
                           information set forth in the registration statement.
                           Notwithstanding the foregoing, any increase or
                           decrease in volume of securities offered (if the
                           total dollar value of securities offered would not
                           exceed that which was registered) and any deviation
                           from the low or high and of the estimated maximum
                           offering range may be reflected in the form of
                           prospectus filed with the Commission pursuant to Rule
                           424(b) if, in the aggregate, the changes in volume
                           and price represent no more than 20 percent change in
                           the maximum aggregate offering price set forth in the
                           ACalculation of Registration Fee@ table in the
                           effective registration statement;

                  (iii)    To include any material information with respect to
                           the plan of distribution not previously disclosed in
                           the registration statement or any material change to
                           such information in the registration statement;

                           PROVIDED, HOWEVER, that paragraphs (1)(i) and (1)(ii)
                           do not apply if the registration statement is on Form
                           S-3 or Form S-8, and the information required to be
                           included in a post-effective amendment by those
                           paragraphs is contained in periodic reports filed
                           with or furnished to the Commission by the Registrant
                           pursuant to section 13 or section 15(d) of the
                           Exchange Act that are incorporated by reference in
                           the registration statement.

         2.       That, for the purpose of determining any liability under the
                  Securities Act, each such post-effective amendment shall be
                  deemed to be a new registration statement relating to the
                  securities offered therein, and the offering of such
                  securities at that time shall be deemed to be the initial bona
                  fide offering thereof.

         3.       To remove from registration by means of a post-effective
                  amendment any of the securities being registered which remain
                  unsold at the termination of the offering.

         4.       The undersigned Registrant hereby undertakes that, for
                  purposes of determining any liability under the Securities
                  Act, each filing of the Registrant's annual report pursuant to
                  section 13(a) or section 15(d) of the Exchange Act (and, where
                  applicable, each filing of an employee benefit plan's annual


                                      II-2
<PAGE>

                  report pursuant to section 15(d) of the Exchange Act) that is
                  incorporated by reference in the registration statement shall
                  be deemed to be a new registration statement relating to the
                  securities offered therein, and the offering of such
                  securities at that time shall be deemed to be the initial bona
                  fide offering thereof.

         5.       Insofar as indemnification for liabilities arising under the
                  Securities Act may be permitted to directors, officers and
                  controlling persons of the Registrant pursuant to the
                  foregoing provisions, or otherwise, the Registrant has been
                  advised that in the opinion of the Commission such
                  indemnification is against public policy as expressed in the
                  Securities Act and is, therefore, unenforceable. In the event
                  that a claim for indemnification against such liabilities
                  (other than the payment by the Registrant of expenses incurred
                  or paid by a director, officer or controlling person of the
                  Registrant in the successful defense of any action, suit or
                  proceeding) is asserted by such director, officer or
                  controlling person in connection with the securities being
                  registered, the Registrant will, unless in the opinion of its
                  counsel the matter has been settled by controlling precedent,
                  submit to a court of appropriate jurisdiction the question
                  whether such indemnification by it is against public policy as
                  expressed in the Securities Act and will be governed by the
                  final adjudication of such issue.


                                      II-3
<PAGE>

                                POWER OF ATTORNEY

           KNOW ALL MEN BY THESE PRESENTS, that each of the undersigned
directors and officers of Vysis, Inc. hereby constitutes and appoints John L.
Bishop and William E. Murray, and each of them, severally, as his true and
lawful attorney-in-fact and agent, for him and in his name, place and stead, in
any and all capacities, with full power to act alone, to sign any and all
amendments to this registration statement, and to file each such amendment to
this registration statement with all exhibits thereto, and any and all documents
in connection therewith, with the Securities and Exchange Commission, hereby
granting unto said attorney-in-fact and agent full power and authority to do and
perform any and all acts and things requisite and necessary to be done in and
about the premises, as fully and to all intents and purposes as he might or
could do in person, hereby ratifying and confirming all that said
attorney-in-fact and agent may lawfully do or cause to be done by virtue hereof.


                                      II-4
<PAGE>


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in Downers Grove, Illinois, on the 29th day of March, 2000.

                                       VYSIS, INC.

                                       By:   /s/ John L. Bishop
                                           -------------------------------------
                                           Name: John L. Bishop
                                           Title:  President and Chief Executive
                                                   Officer

          Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the date indicated.


<TABLE>
<CAPTION>
              NAME                                        TITLE (CAPACITY)                         DATE
              ----                                        ----------------                         ----
<S>                                           <C>                                          <C>
                                               President and Chief Executive Officer
/s/ John L. Bishop                               Officer and Director                        March 29, 2000
- --------------------------------------           (Principal Executive Officer and
John L. Bishop                                   Director)


                                               Vice President of Finance and
/s/ Alfred H. Ellsworth                          Chief Financial Officer                     March 29, 2000
- --------------------------------------           (Principal Financial and
Alfred H. Ellsworth                              Accounting Officer)


/s/ Eileen A. Kamerick                         Director                                      March 29, 2000
- --------------------------------------
Eileen A. Kamerick


/s/ Kenneth L. Melmon                          Director                                      March 29, 2000
- --------------------------------------
Kenneth L. Melmon


/s/ Anthony J. Nocchiero                       Director                                      March 29, 2000
- --------------------------------------
Anthony J. Nocchiero


/s/ Walter R. Quanstrom                        Director                                      March 29, 2000
- --------------------------------------
Walter R. Quanstrom


/s/ Frank J. Sroka                             Director                                      March 29, 2000
- --------------------------------------
Frank J. Sroka
</TABLE>

                                      II-5
<PAGE>


                                  EXHIBIT INDEX

<TABLE>
<CAPTION>
         Exhibit
         Number                         Description of Exhibit
         ------                         ----------------------
<S>                         <C>
         4.1                 Certificate of Incorporation of the Registrant
                             (Incorporated by reference to Exhibit 3.1.1 to
                             3.1.8 to the Registrant's Registration Statement on
                             Form S-1 (File No. 333-38109))

         4.2                 By-Laws of the Registrant, as amended (Incorporated
                             by reference to Exhibit 3.2 to the Registrant's
                             Form 10-K for the year ended December 31, 1999
                             (File No. 000-23659)

         4.3                 Specimen certificate evidencing the Common Stock of
                             the Registrant (Incorporated by reference to
                             Exhibit 4.1 to the Registrant's Registration
                             Statement on Form S-1 (File No. 333-38109))

         4.4                 The 1999 Outside Directors Stock Option Plan of the
                             Registrant (Incorporated by reference to Exhibit A
                             to the Registrant's Proxy Statement for the 1999
                             Annual Meeting of Shareholders filed pursuant to
                             Section 14(a) of the Exchange Act (Exchange Act
                             File No. 000-23659)

         5.1                 Opinion of William E. Murray regarding the validity
                             of the offered securities

         23.1                Consent of William E. Murray (appears in Exhibit 5.1)

         23.2                Consent of Deloitte & Touche LLP

         23.3                Consent of PriceWaterhouseCoopers LLP

         24.1                Power of Attorney (appears on the page preceding the
                             signature page of this Registration Statement)
</TABLE>




<PAGE>

                                                                    Exhibit 5.1

March 29, 2000

Vysis, Inc.
3100 Woodcreek Drive
Downers Grove, IL 60515

         Re: VYSIS, INC. REGISTRATION STATEMENT ON FORM S-8

Dear Sirs:

I have represented Vysis, Inc., a Delaware corporation (the "Company"), in
connection with the registration of 115,000 shares of common stock, $0.001
par value per share, of the Company (the "Shares").

In connection with my representation, I have examined the corporate records
of the Company, including its Certificate of Incorporation and all amendments
thereto, its Bylaws, and other corporate records and documents and have made
such other examinations as I consider necessary to render this opinion. Based
upon the foregoing, it is my opinion that:

     1.  The Company is a corporation duly organized and validly existing in
         good standing under the laws of the State of Delaware; and

     2.  The Shares are legally authorized and, upon receipt by the Company of
         the purchase price therefor, will be legally issued and outstanding,
         fully paid and nonassessable.

I consent to the filing of this opinion as an exhibit to the Registration
Statement referred to above and to all references to the undersigned in such
Registration Statement.

Sincerely yours,


William E. Murray
General Counsel & Secretary
Vysis, Inc.



<PAGE>


                                                           EXHIBIT 23.2

INDEPENDENT AUDITORS' CONSENT

We consent to the incorporation by reference in this Registration Statement
on Form S-8 pertaining  to the Vysis, Inc. 1999 Outside Directors Stock
Option Plan and 1998 Outside Director Stock Option Grants of our report dated
March 10, 2000, appearing in the Annual Report on Form 10-K of Vysis, Inc.
for the year ended December 31, 1999.

DELOITTE & TOUCHE LLP


Chicago, Illinois
March 29, 2000



<PAGE>

                                                           EXHIBIT 23.3


                      CONSENT OF INDEPENDENT ACCOUNTANTS


We hereby consent to the incorporation by reference in this Registration
Statement on Form S-8 of Vysis, Inc. of our report dated March 13, 1998
relating to the consolidated effort financial statements and financial
statement schedule which appears on pages 34 of the Vysis Inc. Annual Report
on Form 10-K for the year ended December 31, 1999.



PRICEWATERHOUSECOOPERS LLP



Chicago, Illinois
March 29, 2000






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