PATIENT INFOSYSTEMS INC
DEF 14A, 1998-05-26
MISC HEALTH & ALLIED SERVICES, NEC
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                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607

May 26, 1998


Dear Stockholder:

You are cordially invited to attend the Patient Infosystems, Inc. Annual Meeting
of Stockholders to be held at 9:30 a.m.  Eastern Daylight Time,  Thursday,  June
25, 1998 in the  Harvard-Oxford  Room at the Strathallan Hotel, 550 East Avenue,
Rochester, New York 14607.

The matters  proposed for  consideration  at the meeting are the election of six
directors,  the  ratification of the appointment of Deloitte & Touche LLP as the
Company's  auditors,  and to  transact  other  business  as may come  before the
meeting or any adjournment thereof. The accompanying Notice of Annual Meeting of
Stockholders  and Proxy Statement  discuss these matters in further  detail.  We
urge you to review this information carefully.

You will have an  opportunity  at the  meeting to discuss  each item of business
described in the Notice of Annual Meeting of  Stockholders  and Proxy  Statement
and to ask questions about the Company and its operations.

It is important that your shares be represented and voted at the Annual Meeting.
Whether or not you plan to attend,  please sign and promptly return the enclosed
proxy card,  using the envelope  provided.  If you do attend the Annual Meeting,
you may withdraw your proxy and vote your shares in person.


Sincerely,

Donald A. Carlberg
President and Chief Executive Officer


<PAGE>


                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 25, 1998

The Annual Meeting of Stockholders of Patient Infosystems,  Inc. will be held on
Thursday, June 25, 1998 at 9:30 a.m. Eastern Daylight Time in the Harvard-Oxford
Room at the Strathallan Hotel, 550 East Avenue, Rochester, New York 14607.

1. To elect six  directors  to hold  office  until the next  Annual  Meeting  of
Stockholders  or until their  respective  successors  have been duly elected and
qualified; 

2. To ratify the  appointment  of Deloitte & Touche LLP as auditors; and 

3. To transact  such other  business as may properly come before the meeting
or any adjournment thereof.

The Board of Directors has fixed the close of business on Thursday, May 21, 1998
as the record date for the  determination of stockholders  entitled to notice of
and to vote at the Annual Meeting of Stockholders.

The Company requests that all stockholders,  whether or not you expect to attend
this meeting,  sign the enclosed  proxy and return it as promptly as possible in
the  accompanying  postage paid envelope.  You may revoke your proxy at any time
before it is voted. If you are present at the meeting,  you may vote your shares
in person and the proxy will not be used.

You are respectfully urged to read the Proxy Statement contained in this booklet
for further  information  concerning  individuals  nominated as  directors,  the
appointment of Deloitte & Touche LLP as auditors and the use of the proxy.

A copy of the Company's  Annual Report to Stockholders for the fiscal year ended
December 31, 1997 accompanies this Proxy Statement.


By Order of the Board of Directors,

Donald A. Carlberg
President and Chief Executive Officer


May 26, 1998






                    IMPORTANT - PLEASE MAIL YOUR SIGNED PROXY
                        PROMPTLY IN THE ENCLOSED ENVELOPE



<PAGE>


                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607

                                 PROXY STATEMENT

         For the Annual Meeting of Stockholders to be held June 25, 1998

This Proxy Statement is furnished in connection with the solicitation of proxies
to be voted at the Annual Meeting of Stockholders of Patient  Infosystems,  Inc.
(the "Company" or "Patient Infosystems"), to be held on Thursday, June 25, 1998,
and at any postponements or adjournments  thereof, for the purposes set forth in
the accompanying Notice of Annual Meeting of Stockholders.  This Proxy Statement
and the proxy are being mailed to stockholders on or about May 26, 1998.

The  enclosed  proxy is  solicited  by the Board of Directors of the Company and
will be  voted  at the  Annual  Meeting  and any  adjournments  thereof.  Shares
represented by a properly  executed proxy in the accompanying form will be voted
at the Annual  Meeting in  accordance  with any  instructions  specified  by the
stockholder.  If no instructions  are given,  the  stockholder's  shares will be
voted in accordance with the  recommendations of the Board of Directors FOR each
of the proposals  presented in this Proxy Statement.  Those  recommendations are
described later in this Proxy Statement.

The proxy may be revoked at any time  before it is  exercised  by  delivering  a
written notice of revocation to the Assistant  Secretary of the Company.  If you
attend the Annual Meeting in person,  you may revoke your proxy by either giving
notice of revocation to the  inspectors of election at the Annual  Meeting or by
voting at the Annual Meeting in person.

The only items of  business  that the Board of  Directors  intends to present or
knows will be  presented at the Annual  Meeting are the items  discussed in this
Proxy  Statement.  The proxy confers  discretionary  authority  upon the persons
named therein, or their substitutes, to vote on any other items of business that
may properly come before the meeting.

Only stockholders of record at the close of business on May 21, 1998, the record
date for the Annual Meeting (the "Record  Date"),  are entitled to notice of and
to vote at the Annual  Meeting.  As of the Record Date the Company had 8,020,042
shares of Common Stock,  par value $.01 per share ("Common  Stock"),  issued and
outstanding.  Each share is entitled to one vote on each matter  submitted  to a
vote at the Annual  Meeting.  A majority  of the issued and  outstanding  shares
constitutes a quorum at the meeting.


                                VOTING PROCEDURES

The  directors  will be elected  by the  affirmative  vote of a majority  of the
shares of Common Stock present in person or  represented  by proxy at the Annual
Meeting,  provided  a quorum  exists.  A quorum  is  established  if, at least a
majority  of the  outstanding  shares of Common  Stock as of the Record Date are
present  in  person  or  represented  by  proxy  at  the  Annual  Meeting.   The
ratification  of Deloitte & Touche LLP as auditors and all other  matters at the
meeting will also be decided by the affirmative vote of a majority of the shares
of Common Stock cast with respect thereto,  provided a quorum exists. Votes will
be counted and certified by one or more  Inspectors of Election who are expected
to be employees of the Company or  Continental  Stock  Transfer & Trust Company,
the Company's stock transfer agent. In accordance with Delaware law, abstentions
and "broker  non-votes" (i.e.  proxies from brokers or nominees  indicating that
such persons have not received  instructions  from the beneficial owner or other
persons entitled to vote shares as to a matter with respect to which the brokers
or nominees do not have discretionary  power to vote) will be treated as present
for  purposes  of  determining  the  presence  of  a  quorum.  For  purposes  of
determining  approval of a matter presented at the meeting,  abstentions will be
deemed  present and  entitled to vote and will,  therefore,  have the same legal
effect as a vote "against" a matter  presented at the meeting.  Broker non-votes
will be  deemed  not  entitled  to vote on the  subject  matter  as to which the
non-vote is indicated and will,  therefore,  have no legal effect on the vote on
that particular  matter.  Each stockholder may revoke a previously granted proxy
at any time before it is exercised by filing with the Assistant Secretary of the
Company  either a notice of revocation or a duly executed  proxy bearing a later
date. The powers of the proxy holders will be suspended if the person  executing
the proxy  attends  the  meeting in person and so  requests.  Attendance  at the
meeting  will not, in itself,  constitute  revocation  of a  previously  granted
proxy.


                      VOTING SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT


The following  table sets forth  certain  information  regarding the  beneficial
ownership of the shares of the Company's Common Stock as of May 21, 1998, (i) by
each person the Company  knows to be the  beneficial  owner of 5% or more of the
outstanding  shares of Common Stock, (ii) each named executive officer listed in
the Summary  Compensation Table, (iii) each director of the Company and (iv) all
executive officers and directors of the Company as a group.

                                                Shares               Percentage
                                             Beneficially           Beneficially
Beneficial Owner (1)                             Owned                  Owned
- --------------------                             -----                  -----

Derace L. Schaffer (2)                          1,718,900               21.4%
John Pappajohn (3)                              1,456,880               18.2%
Edgewater Private Equity Fund II, L.P.
   666 Grand Avenue, Suite 200                    970,000               12.1%
Donald A. Carlberg (4)                            145,000                1.8%
Marion B. LaVigne (5)                              10,080                 *
                                                                   
Victoria Nelson Neidigh (6)                         3,360                 *
                                                                             
Kent Tapper (7)                                    14,500                 *
                                                                             
Barbara J. McNeil (8)                              21,600                 *
                                                                             
Carl F. Kohrt (7)                                  14,400                 *
                                                                             
David B. Nash (9)                                      -                  *
                                                    
All directors and executive officers as a group
   (9 persons) (10)                             3,384,720               42.3%


*  Less than one percent.

(1) Unless otherwise noted, the address of each of the listed persons is c/o the
Company at 46 Prince Street, Rochester, New York 14607.

(2) Includes 288,000 shares held by Dr. Schaffer's minor children. Also includes
14,400  shares which are  issuable  upon the exercise of options that are either
currently  exercisable  or which  become  exercisable  within 60 days of May 21,
1998.  Does not include 21,600 shares  subject to outstanding  options which are
not exercisable within 60 days of May 21, 1998.

(3) Includes 360,000 shares held by Halkis, Ltd., a sole proprietorship owned by
Mr. Pappajohn,  360,000 shares held by Thebes, Ltd., a sole proprietorship owned
by Mr.  Pappajohn's  spouse and 360,000 shares held directly by Mr.  Pappajohn's
spouse.  Mr.  Pappajohn  disclaims  beneficial  ownership of the shares owned by
Thebes, Ltd. and by his spouse. Includes options to purchase 14,400 shares which
are either currently  exercisable or which become  exercisable within 60 days of
May 21, 1998.  Does not include  21,600 shares  subject to  outstanding  options
which are not exercisable within 60 days of May 21, 1998.

(4) Includes 1,000 shares held by Mr. Carlberg's minor child. Represents options
to purchase  144,000  shares  which are either  currently  exercisable  or which
become  exercisable  within 60 days of May 21,  1998.  Does not  include  90,000
shares subject to outstanding  options which are not exercisable  within 60 days
of May 21, 1998.

(5)  Includes  options to  purchase  10,080  shares  which are either  currently
exercisable or which become exercisable within 60 days of May 21, 1998. Does not
include 57,920 shares subject to outstanding  options which are not  exercisable
within 60 days of May 21, 1998.

(6)  Includes  options and  warrants to purchase  3,360  shares which are either
currently  exercisable  or which  become  exercisable  within 60 days of May 21,
1998. Does not include 63,440 shares subject to outstanding options and warrants
which are not exercisable within 60 days of May 21, 1998.

(7)  Includes  options to  purchase  14,400  shares  which are either  currently
exercisable or which become exercisable within 60 days of May 21, 1998. Does not
include 21,600 shares subject to outstanding  options which are not  exercisable
within 60 days of May 21, 1998.

(8)  Includes  options and warrants to purchase  21,600  shares which are either
currently  exercisable  or which  become  exercisable  within 60 days of May 21,
1998. Does not include 14,400 shares subject to outstanding options and warrants
which are not exercisable within 60 days of May 21, 1998

(9)  Includes  options and  warrants to purchase  5,760  shares which are either
currently  exercisable  or which  become  exercisable  within 60 days of May 21,
1998. Does not include 64,640 shares subject to outstanding options and warrants
which are not exercisable within 60 days of May 21, 1998

(10)  Includes  options  and  warrants  to  purchase  242,400  which are  either
currently  exercisable  or which  become  exercisable  within 60 days of May 21,
1998.  Does not  include  376,800  shares  subject to  outstanding  options  and
warrants which are not exercisable within 60 days of May 21, 1998.


                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

At this year's Annual Meeting of Stockholders,  six directors will be elected to
hold office for a term expiring at the next Annual Meeting of Stockholders. Each
director  will be elected to serve until a successor is elected and qualified or
until the director's earlier resignation or removal.

Proxies granted by stockholders will be voted individually for the election,  as
directors of the Company,  of the persons listed below, unless a proxy specifies
that it is not to be voted in favor of a nominee for director.  In the event any
of the nominees  listed below shall be unable to serve,  it is intended that the
proxy will be voted for such other  nominees as are  designated  by the Board of
Directors.  Each of the  persons  named  below  has  indicated  to the  Board of
Directors of the Company that they are available to serve.

The names,  ages,  principal  occupations and other  information  concerning the
director  nominees,  based upon  information  received from them,  are set forth
below.

Derace L.  Schaffer,  M.D., 50 (Chairman of the Board of Directors  since 1995).
Dr.  Schaffer  has  been  the  President  of The Ide  Group,  P.C.,  a group  of
physicians  providing  radiological  services at multiple  locations in New York
State, since 1980, and since 1990 he has also been President of The Lan Group, a
venture  capital firm  specializing in health care  investments.  He serves as a
Clinical  Professor  at the  University  of  Rochester  School of Medicine and a
Director of American Physician Partners,  Inc., Medifax, Inc., NeuralMed,  Inc.,
NeuralTech,  Inc., Oncor, Inc., Preferred Oncology Networks of America, Inc. and
The Care Group, Inc. and as well as several not-for-profit corporations.

Donald A. Carlberg,  45 (Director since 1995).  Mr. Carlberg has been President,
Chief  Executive  Officer and a Director of the Company  since its  inception in
February 1995.  From February 1993 to December 1994 Mr. Carlberg served as Chief
Executive Officer of Patient Management  Technologies,  Inc., a medical services
consulting company,  which he founded.  From 1992 to 1994 Mr. Carlberg served as
Senior Vice President,  Sales and Marketing for Neurocare,  Inc./Paradigm Health
Corp.  From 1990 to 1992 Mr.  Carlberg  served as Director  of Managed  Care for
Baxter  Healthcare  International  where he started managed care initiatives for
its Caremark Division.  From 1985 to 1990 Mr. Carlberg held several senior level
positions in managed care at Blue Cross/Blue  Shield of Rochester,  New York and
Independence Blue Cross in Philadelphia, Pennsylvania.

Carl F. Kohrt,  Ph.D.,  54 (Director  since 1996).  Dr. Kohrt is Executive  Vice
President and Assistant  Chief  Operating  Officer of the Eastman Kodak Company,
where he has served in various  capacities  since 1971. Dr. Kohrt is a recipient
of a Sloan Fellowship for study at Massachusetts Institute of Technology.

Barbara J. McNeil,  M.D., Ph.D., 57 (Director since 1995). Dr. McNeil is Head of
the  Department  of Health Care Policy and a Professor  of  Radiology at Harvard
Medical School where she has served in various  capacities  since 1971. For four
years  she  has  served  as  Chair  of the  Blue  Cross  Massachusetts  Hospital
Association Fund for Cooperative Innovation and currently she is a member of the
National Council on Radiation Protection,  the American College of Radiology and
its Board of Chancellors,  the Society of Nuclear Medicine, the Advisory Council
for the Agency for Health Care Policy and Research  and the National  Academy of
Sciences'  Institute of Medicine where she is a Council member.  She also serves
as a Director of CV Therapeutics, Inc.

David B. Nash,  M.D.,  42 (Director  since April 1998) has been  Executive  Vice
President,  Medical  Affairs  of the  Company  since  April  1996.  Dr.  Nash is
currently  and has been for at least the last  five  years,  Director  of Health
Policy  and  Clinical  Outcomes  at Thomas  Jefferson  University  Hospital  and
Associate  Professor of Medicine at Jefferson  Medical College.  Dr. Nash is the
recipient of the 1995 Clifton  Latiolias Prize in Managed Care from the American
Managed Care Pharmacy Association. He also serves as a scientific advisory board
member of iSTAT  Corp.  Dr.  Nash  provides  his  services  to the  Company on a
part-time consulting basis.

John Pappajohn,  69 (Director since 1995). Mr. Pappajohn has been the sole owner
of Pappajohn  Capital  Resources,  a venture capital firm specializing in health
care investments, and President of Equity Dynamics, Inc., a financial consulting
firm, both located in Des Moines,  Iowa, since 1969. He serves as a Director for
the following public companies:  CORE, Inc., Drug Screening Systems, Inc., Fuisz
Technologies, Ltd., GalaGen, Inc., HealthDesk Corporation,  OncorMed, Inc., Pace
Health Management Systems, Inc. and The Care Group, Inc.

During the 1997 fiscal year there were five  meetings of the Board of Directors.
Each  Director  attended  at least  80% of the  aggregate  total  number  of the
meetings of the Board of Directors held during the year.

The Board of Directors has standing  Audit and  Compensation  Committees,  which
deal with certain specific areas of the Board's responsibility.

The Audit Committee,  which met once during the 1997 fiscal year, recommends the
firm to be appointed as  independent  public  accountants to audit the Company's
financial  statements  and  reviews the scope and results of the audit and other
services provided by the Company's  independent public accountants.  The members
of the Audit Committee are Mr. Pappajohn, Dr.
McNeil, and Dr. Kohrt.

The Compensation Committee, which met once during the 1997 fiscal year, develops
the Company's executive  compensation  philosophy and reviews and recommends the
compensation  programs  for  officers of the  Company,  including  salaries  and
incentive   compensation.   The  Compensation  Committee  also  administers  the
Company's Employee Stock Option Plan. The members of the Compensation  Committee
are Dr. Schaffer, Dr. McNeil and Dr. Kohrt.

Directors who are not currently receiving  compensation as officers or employees
of the Company are  entitled to  reimbursement  of expenses for  attending  each
meeting of the Board of Directors  and each meeting of any  committee.  Dr. Nash
provides  consulting  services to the Company with  respect to certain  medicine
matters. In 1997, Dr. Nash received $25,000 in consulting fees from the Company.

The Company's  directors are eligible to participate  in the Company's  Employee
Stock Option  Plan.  Pursuant to the  Employee  Stock Option Plan,  non-employee
directors  of the  Company  receive a one-time  grant of a  non-qualified  stock
option to purchase  36,000 shares of the  Company's  Common Stock at an exercise
price equal to fair market value per share on the date of their initial election
to the Company's Board of Directors. Such non-qualified stock option vests as to
20% of the option grant on the first  anniversary of the grant,  and 20% on each
subsequent  anniversary,  is exercisable only during the non-employee director's
term and automatically  expires on the date such director's service  terminates.
Upon the  occurrence  of a change of control,  as defined in the Employee  Stock
Option Plan, all outstanding unvested options immediately vest.

Section 16(a) of the Exchange Act requires that the Company's executive officers
and directors,  and beneficial owners of 10% or more of the Company's stock file
initial reports of ownership and of changes of ownership with the Securities and
Exchange Commission and the NASDAQ Stock Market.  Executive officers,  directors
and 10% beneficial owners are required by securities  regulations to furnish the
Company with copies of all Section 16(a) forms they file.

Based on a review of the copies of reports furnished to the Company, the Company
believes  that during the year ended  December 31, 1997 all filing  requirements
applicable to its officers,  directors  and ten percent  beneficial  owners were
met,  except that initial  reports of beneficial  ownership on Form 3 were filed
late for Leonard M. Serafino, the former Chief Operating Officer of the Company.



                             EXECUTIVE COMPENSATION

The following table sets forth the  compensation  paid or accrued by the Company
for services  rendered in all capacities  for executive  officers of the Company
who received  compensation in excess of $100,000 during the years ended December
31, 1997 and 1996 and during the period from  inception  on February 22, 1995 to
December 31, 1995.

                           Summary Compensation Table
<TABLE>
<CAPTION>
                                                                                               Long-Term
                                                                                              Compensation
                                                                                                 Awards
                                                            Annual Compensation                Securities
Name and Principal Position                 Year          Salary           Bonus         Underlying Options (#)
- ---------------------------                 ----          ------           -----         ----------------------
<S>                                          <C>           <C>              <C>             <C>    
                                           
                                                      
Donald A. Carlberg, President and Chief     1997          $161,538          $25,000                 0
Executive Officer                           1996          $131,731          $25,000            18,000
                                            1995 (1)       $96,417          $15,000           216,000

Kent Tapper, Chief Information Officer      1997          $101,923          $10,000                 0
                                            1996           $86,298           $5,000                 0
                                            1995 (1)       $32,308               $0            36,000
</TABLE>


(1) Reflects  compensation  paid from inception on February 22, 1995 to December
31, 1995.

Marion B. LaVigne,  Ph.D. and Victoria Nelson Neidigh, who were recently elected
as officers of the Company,  were not executive  officers  during the year ended
December 31, 1997.  However,  Ms. Neidigh received salary of $101,754 during the
year ended  December 31, 1997.  Ms.  LaVigne and Ms.  Neidigh are each currently
compensated  at the rate of $115,000  annually.  No options were granted  during
1997 to either of the named executive officers.  No stock options were exercised
by the Chief Executive Officer or other named executive  officers of the Company
during  1997.  The  following  table sets forth  certain  information  regarding
unexercised  options  held by the Chief  Executive  Officer  and the other named
executive officer of the Company at December 31, 1997.

                       Option Values on December 31, 1997
<TABLE>
<CAPTION>

                                  Number of Securities Underlying                 Value of Unexercised
                                      Unexercised Options at                     In-the-Money Options at
                                       December 31, 1997(#)                      December 31, 1997($)(1)
                                       --------------------                      -----------------------
  Name                        Exercisable          Unexercisable             Exercisable      Unexercisable
  ----                        -----------          -------------             -----------      -------------
<S>                            <C>                  <C>                       <C>              <C> 
 
 Donald A. Carlberg                  111,600           122,400                $295,740             $324,360
 Kent A. Tapper                       14,400            21,600                 $38,160              $57,240
</TABLE>

(1) Calculated based upon $2.65 market value of the underlying  securities as of
December 31, 1997.

The Company's Stock Option Plan (the "Plan") was originally adopted by the Board
of Directors and  stockholders  in June 1995.  Up to 1,080,000  shares of Common
Stock have been  authorized and reserved for issuance under the Plan.  Under the
Plan,  options may be granted in the form of incentive stock options ("ISOs") or
non-qualified  stock options  ("NQOs") from time to time to salaried  employees,
officers,  directors  and  consultants  of the  Company,  as  determined  by the
Compensation  Committee of the Board of Directors.  The  Compensation  Committee
determines the terms and conditions of options granted under the Plan, including
the exercise  price.  The Plan  provides that the  Committee  must  establish an
exercise price for ISOs that is not less than the fair market value per share at
the date of the grant.  However, if ISOs are granted to persons owning more than
10% of the voting  stock of the  Company,  the Plan  provides  that the exercise
price must not be less than 110% of the fair market  value per share at the date
of the grant. The Plan also provides for a non-employee  director to be entitled
to receive a one-time  grant of a NQO to purchase  36,000  shares at an exercise
price equal to fair market value per share on the date of their initial election
to the Company's  Board of Directors.  Such NQO is  exercisable  only during the
non-employee  director's  term  and  automatically  expires  on  the  date  such
director's service terminates.  Each option,  whether an ISO or NQO, must expire
within ten years of the date of the grant.

As of December 31, 1997 there were 798,060 options  outstanding  under the Plan,
having  exercise  prices ranging from $0.14 to $10.00 per share. As of March 17,
1998, the Board of Directors of the Company voted to reprice options to purchase
72,900 shares of common stock granted to 19 employees of the Company, which were
granted from November 1996 to June 1997 at prices  ranging from $5.13 to $10.00,
to an  exercise  price of $3.13,  being the fair market  value of the  Company's
common  stock on such date.  No  director  nor named  executive  officer had any
options  repriced on such date.  Marion B. LaVigne,  Ph.D.  and Victoria  Nelson
Neidigh had 16,800  options to purchase 1,800 and 15,000 shares of common stock,
respectively, repriced on such date.

Employment Agreement

The Company has entered into an employment  agreement  with Mr.  Carlberg as its
President and Chief Executive  Officer dated March 1, 1995,  which has a term of
one year and is  automatically  renewed for successive  one-year  periods unless
either  party  receives  written  notice  from the other  party of such  party's
intention not to renew within 60 days of the  agreement's  expiration  date. The
agreement  calls for Mr. Carlberg to receive a base salary of $125,000 per year,
which was increased to $150,000 per year in September  1996 and $175,000 in June
1997. Upon execution of the agreement,  Mr. Carlberg  received a $15,000 signing
bonus and an option to  purchase  up to  180,000  shares of Common  Stock of the
Company at an exercise price of $.14 per share, and in March of 1996 and 1997 he
received  bonuses of $25,000.  The option has a ten-year  term,  vests over five
years and was 20% vested upon grant. The remainder of the option vests at a rate
of 20% per year, and the option is therefore fully  exercisable  after the first
five years of employment. Mr. Carlberg is eligible for any discretionary bonuses
and additional  option grants in amounts to be determined by the Company's Board
of Directors  based upon the  performance of the Company and Mr.  Carlberg.  The
agreement  prohibits  Mr.  Carlberg  from  engaging  in  any  business  activity
involving  the  measurement  of clinical  outcomes  for  patients  with acute or
chronic  diseases,  or the  measurement of patient  compliance  with  prescribed
treatments for acute or chronic  diseases  within one year of the termination of
his employment with the Company.



                      REPORT OF THE COMPENSATION COMMITTEE
                            OF THE BOARD OF DIRECTORS

Compensation for the Company's executive officers was determined in light of the
responsibilities  involved in  commencing  the  Company's  business  operations,
developing its initial and ongoing customer  relationships,  commencing  patient
information  programs and  negotiating  with the Company's  investment  bankers.
During 1997, Mr. Carlberg received a bonus of $25,000  reflecting Mr. Carlberg's
efforts in connection  with the expansion of the  Company's  operations  and the
substantial roll-out of the Company's patient information systems.

The Compensation  Committee  evaluates the performance of each executive officer
of the Company in the context of the goals and challenges that the Company faces
over the next  year.  The  determinations  as to salary  and bonus are made in a
context of the challenges  faced in the Company,  the individual  performance of
the individual  and the salaries of executives at  comparative  companies in the
Company's industry.
                                                          Dr. Derace L. Schaffer
                                                           Dr. Barbara J. McNeil
                                                               Dr. Carl F. Kohrt

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

The Company was initially  capitalized  on February 22, 1995 through the sale of
3,600,000  shares of its  Common  Stock for $.14 per share.  Included  among the
participants in that  transaction  were Dr. Derace L. Schaffer,  Chairman of the
Board,  who purchased  1,656,000  shares,  Dr.  Schaffer's  spouse who purchased
144,000 shares, John Pappajohn, a director, who purchased 541,800 shares, a sole
proprietorship  owned by Mr.  Pappajohn  which  purchased  360,000  shares,  Mr.
Pappajohn's  spouse,  who purchased  360,000 shares,  and a sole  proprietorship
owned by Mr. Pappajohn's spouse which purchased 360,000 shares.

In August and September of 1995 the Company sold 1,800,000  shares of its Series
A Preferred Stock in a private placement for $1.00 per share. Included among the
participants in that  transaction  were Gregory D. Brown,  who was at such time,
the  Company's  Sr. Vice  President,  Chief  Financial  Officer,  Secretary  and
Treasurer,  who purchased  10,000 shares and Mr.  Pappajohn who purchased 10,000
shares. In addition,  Edgewater Private Equity Fund II, L.P.,  ("Edgewater"),  a
five percent owner of the Common Stock of the Company, acquired 1,000,000 shares
of Series A Convertible  Preferred  Stock in the Series A Convertible  Preferred
Stock  offering.  Each share of Series A  Convertible  Preferred  Stock has been
converted into .72 shares of the Company's Common Stock.

In May and June of  1996,  the  Company  sold  600,000  shares  of its  Series B
Convertible Preferred Stock in a private placement for $5.00 per share. Included
among the  participants in that  transaction  were Dr.  Schaffer,  who purchased
20,000 shares,  Mr.  Pappajohn,  who purchased 40,000 shares and Edgewater which
purchased 200,000 shares. Each share of Series B Convertible Preferred Stock has
been converted into 1.25 shares of the Company's Common Stock.


                            COMPANY PERFORMANCE GRAPH

The following  graph compares the  cumulative  total  stockholder  return on the
Common Stock of Patient  Infosystems,  Inc. from December 19, 1996 (the date the
Common Stock was first offered to the public at an initial public offering price
of $8.00 per share) through  December 31, 1997 with the cumulative  total return
on the NASDAQ Stock Market - U.S. Index and the  cumulative  total return on the
NASDAQ Health Services Index.  The Company did not pay any dividends during this
period.  The NASDAQ Stock  Market - U.S.  Index and the NASDAQ  Health  Services
Index are published daily.

The graph assumes an investment  of $100 in each of Patient  Infosystems,  Inc.,
the NASDAQ Stock Market - U.S.  Index and the NASDAQ  Health  Services  Index on
December  31,  1997.  The  Comparison   also  assumes  that  all  dividends  are
reinvested.


                      COMPARISON OF CUMULATIVE TOTAL RETURN
                AMONG PATIENT INFOSYSTEMS, INC., THE NASDAQ STOCK
            MARKET - U.S. INDEX AND THE NASDAQ HEALTH SERVICES INDEX
                                
(The following table is represented as a line chart in the printed material) 
                                                          
                                      12/19/96         12/31/96         12/31/97
                                      --------         --------         --------
Patient Infosystems, Inc.               100.00           115.63            33.13
NASDAQ Stock Market - U.S. Index        100.00            99.49           122.15
NASDAQ Health Services Index            100.00           100.55           103.16

The  comparisons  in this table are required by the rules of the  Securities and
Exchange  Commission  and are not  intended  to  forecast  or be  indicative  of
possible  future  performance  of the Company's  Common  Stock.  The stock price
performance  graph shall not be deemed to be incorporated  into any filing under
the Securities Act or the Exchange Act,  notwithstanding  any general  statement
contained in any such filing  incorporating  this Proxy  Statement by reference,
except to the extent that the Company specifically incorporates this information
by reference.

                                   PROPOSAL 2
                         RATIFICATION OF APPOINTMENT OF
                              INDEPENDENT AUDITORS

The independent public accounting firm utilized by the Company during the fiscal
years  ended  December  31,  1995,  1996  and 1997 was  Deloitte  & Touche  LLP,
independent  certified public accountants.  Although the appointment of auditors
is not  required  to be  submitted  to a vote  of  stockholders,  the  Board  of
Directors  believes that it is appropriate as a matter of policy to request that
the stockholders  ratify the appointment.  If the stockholders should not ratify
the  appointment,  the Audit  Committee  will  investigate  the  reasons for the
stockholders'   rejection  and  the  Board  of  Directors  will  reconsider  the
appointment.  It is expected that a representative of Deloitte & Touche LLP will
be present at the meeting.

The Board of Directors  unanimously  recommends that the  stockholders  vote FOR
ratification  of the  appointment  of  Deloitte  & Touche  LLP as the  Company's
independent auditors.


                  STOCKHOLDER PROPOSALS FOR 1999 ANNUAL MEETING

Stockholders who wish to present proposals  appropriate for consideration at the
Company's 1999 Annual Meeting of Stockholders must submit the proposal in proper
form to the  Company  at its  address  set forth on the first page of this Proxy
Statement  not later than  January 26, 1999 in order for the  proposition  to be
considered  for  inclusion in the  Company's  proxy  statement and form of proxy
relating to such annual meeting.  Any such  proposals,  as well as any questions
related thereto, should be directed to the Assistant Secretary of the Company.


                             ADDITIONAL INFORMATION

The expenses in connection with the solicitation of proxies will be borne by the
Company. Solicitation will be made by mail, but may also be made by telephone or
personal call by officers, directors or employees of the Company who will not be
specially  compensated  for such  solicitation.  The Company  may  request  that
brokerage  houses  and  other  nominees  or  fiduciaries  forward  copies of the
Company's Proxy Statement and Annual Report to Stockholders to beneficial owners
of stock held in their names,  and the Company may reimburse them for reasonable
out-of-pocket expenses incurred in doing so

A COPY OF THE COMPANY'S  ANNUAL  REPORT FOR THE YEAR ENDED  DECEMBER 31, 1997 IS
BEING  FURNISHED  HEREWITH  TO EACH  STOCKHOLDER  OF  RECORD  AS OF THE CLOSE OF
BUSINESS ON MAY 21, 1998.  COPIES OF THE  COMPANY'S  ANNUAL  REPORT ON FORM 10-K
WILL BE PROVIDED FOR A NOMINAL CHARGE UPON WRITTEN REQUEST TO:

                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607
                            Attention: Lynda J. Bates


                                         By Order of the Board of Directors,

                                         Donald A. Carlberg
                                         President and Chief Executive Officer



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