PATIENT INFOSYSTEMS INC
S-8, 2000-05-03
MISC HEALTH & ALLIED SERVICES, NEC
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                 --------------

                                    FORM S-8
                             REGISTRATION STATEMENT

                        UNDER THE SECURITIES ACT OF 1933

                                 --------------

                            PATIENT INFOSYSTEMS, INC.
             (Exact name of registrant as specified in its charter)

         Delaware                                   16-1476509
         --------                                   ----------
(State or other jurisdiction               (I.R.S. Employer Identification No.)
 of incorporation or organization)

46 Prince Street, Rochester, New York                  14607
- -------------------------------------                  -----
(Address of principal executive offices)            (Zip Code)

                   PATIENT INFOSYSTEMS, INC. STOCK OPTION PLAN
                   -------------------------------------------
                            (Full title of the plan)

                          Mr. Roger Louis Chaufournier
                      President and Chief Executive Officer

                                46 Prince Street
                            Rochester, New York 14607

                     (Name and address of agent for service)

                                 (716) 242-7200

          (Telephone number, including area code, of agent for service)

                                    Copy to:
                             Jeffrey A. Baumel, Esq.
                 Gibbons, Del Deo, Dolan, Griffinger & Vecchione

                              One Riverfront Plaza
                          Newark, New Jersey 07102-5497

                                 (973) 596-4500

                         Calculation of Registration Fee

<TABLE>
<CAPTION>

                                                             Proposed          Proposed
                                          Amount          Maximum Offering      Maximum           Amount of
Title of Securities                       To Be               Price            Aggregate        Registration
to be Registered                       Registered(1)       Per Share(2)     Offering Price(2)       Fee(2)
- ----------------                       -------------       ------------     -----------------       ------
<S>                                    <C>                <C>             <C>                    <C>

Common Stock,  $.01 par value per share   1,680,000          $1.1875         $1,995,000             $526.68
</TABLE>

         (1)  Pursuant  to Rule  416(c)  under the  Securities  Act of 1933,  as
amended,  this  registration  statement also covers  additional shares of Common
Stock pursuant to the anti-dilution provisions of the Plan.

         (2) Estimated in accordance with Rule 457(c) solely for the purposes of
calculating the  registration  fee, based on the average high and low prices per
share of the Registrant's Common Stock as reported on The Nasdaq National Market
System on April 27, 2000.

<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

         The following documents previously filed by Patient  Infosystems,  Inc.
(the "Company") with the Securities and Exchange  Commission (the  "Commission")
are incorporated by reference in this Registration Statement:

     (1)  The Company's  Annual Report on Form 10-K (File No.  000-22319)  filed
          March 30, 2000 under the  Securities  Exchange Act of 1934, as amended
          (the  "Exchange  Act") and the Company's  Notice of Annual Meeting and
          Proxy  Statement  (File No.  000-22319)  filed May 18,  1999 under the
          Exchange Act (the "Proxy Statement");

     (2)  The  description  of the Company's  common  stock,  $.01 par value per
          share  (the  "Common   Stock"),   contained  in  the  foregoing  Proxy
          Statement; and

     (3)  All documents  subsequently  filed by the Company pursuant to Sections
          13(a),  13(c),  14 and 15(d) of the  Securities  Exchange Act of 1934,
          prior to the filing of a post-effective  amendment that indicates that
          all  securities  offered  have  been  sold  or  that  deregisters  all
          securities then remaining  unsold,  shall be deemed to be incorporated
          by reference in this  Registration  Statement  and to be a part hereof
          from the respective  date of filing of such  documents.  Any statement
          contained in a document  incorporated by reference  herein is modified
          or  superseded  for  all  purposes  to the  extent  that  a  statement
          contained in this Registration  Statement or in any other subsequently
          filed document that is incorporated by reference  modifies or replaces
          such statement.

Item 4.  Description of Securities.

         Not applicable.

Item 5.  Interests of Named Experts and Counsel.

         Not applicable.

Item 6.  Indemnification of Directors and Officers.

         Section  145 of the  General  Corporation  Law of the State of Delaware
provides  for the  indemnification  of  officers  and  directors  under  certain
circumstances  against  expenses  incurred in successfully  defending  against a
claim and  authorizes  Delaware  corporations  to indemnify  their  officers and
directors under certain  circumstances against expenses and liabilities incurred
in legal  proceedings  involving  such persons  because of their being or having
been an officer or director.

         Section  102(b)  of the  Delaware  General  Corporation  Law  permits a
corporation,  by so providing in its certificate of incorporation,  to eliminate
or limit  director's  liability  to the  corporation  and its  stockholders  for
monetary  damages  arising out of certain  alleged  breaches of their  fiduciary
duty. Section 102(b)(7) provides that no such limitation of liability may affect
a director's liability with respect to any of the following: (i) breaches of the
director's duty of loyalty to the corporation or its stockholders;  (ii) acts or
omissions  not made in good faith or that involve  intentional  misconduct  or a
knowing   violation  of  law;  (iii)  liability  for  dividends  paid  or  stock
repurchased or redeemed in violation of the Delaware General Corporation Law; or
(iv) any  transaction  from  which the  director  derived an  improper  personal
benefit.  Section  102(b)(7) does not authorize any limitation on the ability of
the  corporation  or its  stockholders  to obtain  injunctive  relief,  specific
performance or other equitable relief against directors.

         Article 8 of the Company's  Certificate of Incorporation  provides that
no  director  of the Company  shall be  personally  liable to the Company or its
stockholders  for monetary  damages for breach of fiduciary  duty as a director,
except to the extent such exemption from liability or limitation  thereof is not
permitted under the Delaware General Corporation Law.

Item 7.  Exemption from Registration Claimed.

         Not applicable.

Item 8.  Exhibits.

Exhibit No.           Description
- -----------           -----------
     4.1  Patient Infosystems, Inc. Stock Option Plan, as amended.

     4.2  The Company's  Certificate of Incorporation,  as amended, in effect as
          of the date of this Registration Statement  (incorporated by reference
          to Exhibit 3.1 to the  Company's  Registration  Statement  on Form S-1
          (File No. 333-07643), filed July 3, 1996).

     4.3  By-Laws of the Company  (incorporated  by  reference to Exhibit 3.3 to
          the Company's Registration Statement on Form S-1 (File No. 333-07643),
          filed July 3, 1996).
     5.1  Opinion of Gibbons, Del Deo, Dolan, Griffinger & Vecchione.
     23.1 Consent of Deloitte & Touche LLP.
     23.2 Consent of Gibbons,  Del Deo, Dolan,  Griffinger & Vecchione (included
          in Exhibit 5.1).

Item 9.  Undertakings.

         The undersigned registrant hereby undertakes:

     (1) To file,  during any period in which  offers or sales are being made, a
post-effective amendment to this registration statement:

          (i) To include  any  prospectus  required  by Section  10(a)(3) of the
     Securities Act of 1933;

          (ii) To reflect in the  prospectus  any facts or events  arising after
     the  effective  date of the  registration  statement  (or the  most  recent
     post-effective amendment thereof) which,  individually or in the aggregate,
     represent  a  fundamental  change  in  the  information  set  forth  in the
     registration  statement.  Notwithstanding  the  foregoing,  any increase or
     decrease  in volume of  securities  offered (if the total  dollar  value of
     securities  offered  would not exceed  that which was  registered)  and any
     deviation from the low or high end of the estimated  maximum offering range
     may be  reflected  in the form of  prospectus  filed  with  the  Commission
     pursuant  to Rule  424(b) if, in the  aggregate,  the changes in volume and
     price represent no more than a 20% change in the maximum aggregate offering
     price set  forth in the  "Calculation  of  Registration  Fee"  table in the
     effective registration statement;

          (iii) To include any material  information with respect to the plan of
     distribution not previously disclosed in the registration  statement or any
     material change to such information in the registration statement.

     (2) That, for the purpose of determining any liability under the Securities
Act of 1933,  each  such  post-effective  amendment  shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3) To remove from registration by means of a post-effective  amendment any
of the securities  being registered that remain unsold at the termination of the
offering.

     The  undersigned   registrant  hereby  undertakes  that,  for  purposes  of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual report pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934 (and where  applicable,  each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934) that is incorporated by reference in the  registration  statement shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


<PAGE>


                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Rochester,  State of New York, on this 2nd day of May
2000.

                                                     PATIENT INFOSYSTEMS, INC.

                                                    /s/ Roger Louis Chaufournier
                                                    ----------------------------
                                                    Roger Louis Chaufournier
                                                    President and Chief
                                                      Executive Officer

     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  registration  statement  has been signed by the  following  persons in the
capacities and on the dates indicated.

Signature                           Title                            Date
- ---------                           -----                            ----
/s/Roger Louis Chaufournier         Director, President and Chief    May 2, 2000
- ---------------------------------   Executive Officer
Roger Louis Chaufournier           (Principal Executive Officer)


/s/Kent A. Tapper                   V.P. Financial Planning          May 2, 2000
- ---------------------------------
Kent A. Tapper


/s/Derace L. Schaffer, M.D.         Chairman of the Board            May 2, 2000
- ---------------------------------
Derace L. Schaffer, M.D.


/s/John Pappajohn                   Director                         May 2, 2000
- ---------------------------------
John Pappajohn


/s/Barbara J. McNeil, M.D., Ph.D.   Director                         May 2, 2000
- ---------------------------------
Barbara J. McNeil, M.D., Ph.D


/s/Carl F. Kohrt, Ph.D.             Director                         May 2, 2000
- ---------------------------------
Carl F. Kohrt, Ph.D.

<PAGE>


<TABLE>
<CAPTION>



                                  EXHIBIT INDEX

  No.              Description                               Method of Filing
  ---              -----------                               ----------------
<S>      <C>                                       <C>

  4.1    Patient Infosystems, Inc. Stock Option    Filed by reference to Exhibit 4.1.

  4.2    Certificate of Incorporation, as amended  Filed by reference to Exhibit 3.1 to the
                                                   Company's Registration Statement on Form
                                                   S-1 (File No. 333-07643) filed July 3, 1996.

  4.3    By-Laws                                   Filed by reference to Exhibit 3.3 to the
                                                   Company's Registration Statement on Form
                                                   S-1 (File No. 333-07643) filed July 3, 1996.

  5.1    Opinion of Gibbons, Del Deo, Dolan,       Filed with this Registration Statement.

  23.1   Consent of Deloitte & Touche LLP          Filed with this Registration Statement.

  23.2   Consent of Gibbons, Del Deo, Dolan,       Included in Exhibit 5.1.
</TABLE>


                                                                     Exhibit 4.1

                            PATIENT INFOSYSTEMS, INC.
                     AMENDED AND RESTATED STOCK OPTION PLAN

     1. Purpose. The PATIENT INFOSYSTEMS, INC. AMENDED AND RESTATED STOCK OPTION
PLAN (hereinafter  referred to as the "Plan") is designed to furnish  additional
incentive to both key employees and  Directors of Patient  Infosystems,  Inc., a
Delaware corporation (hereinafter referred to as the "Company"), and its parents
or  subsidiaries,  upon whose  judgment,  initiative  and efforts the successful
conduct of the business of the Company  largely  depends,  by  encouraging  such
persons to acquire a  proprietary  interest in the  Company or to  increase  the
same,  and to strengthen the ability of the Company to attract and retain in its
employ,  or as a  member  of  the  Board  of  Directors,  persons  of  training,
experience  and ability.  Such purpose will be effected  through the granting of
"Incentive  Stock  Options"  within the meaning of Section  422 of the  Internal
Revenue Code of 1986, as amended  (hereinafter  the "Code") and options which do
not qualify as incentive stock options ("Non-Qualified Options").

     2. Administration.

     (a) The Plan shall be  administered  by a committee  chosen by the Board of
Directors  of the Company  (the  "Committee")  and  decisions  of the  Committee
concerning the  interpretation and construction of any provisions of the Plan or
of any option granted pursuant to the Plan shall be final. In the absence of the
Committee,  the Plan  will be  administered  by the  Board of  Directors  of the
Company.  The  Company  shall  effect  the  grant of  options  under the Plan in
accordance  with the decisions of the  Committee,  which may, from time to time,
adopt rules and  regulations  for the carrying out of the Plan.  For purposes of
the Plan, an option shall be deemed to be granted when a written Option Contract
is signed on behalf of the Company by a member of the Committee.  Subject to the
express  provisions of the Plan, the Committee shall have the authority,  in its
discretion  and without  limitation:  to determine  the  individuals  to receive
options,  the times when such individuals  shall receive options,  the number of
Shares to be subject to each  option,  the term of each  option,  the date(s) on
which each  option  shall  become  exercisable,  whether an option is subject to
vesting pursuant to Section 5(c) hereof,  whether an option shall be exercisable
in whole,  in part,  or in  installments,  the number of Shares to be subject to
each installment,  the date each installment shall become exercisable,  the term
of each installment,  the option price of each option,  and the terms of payment
for Shares  purchased by the exercise of each option;  to accelerate the date of
exercise of any installment;  and to make all other determinations  necessary or
advisable for administering the Plan.

     (b) The Committee may grant Incentive Stock Options and Non-Qualified Stock
Options  pursuant to a single option agreement so long as each option is clearly
identified  as to its status.  Notwithstanding  anything  else  contained in the
Plan, if the  Committee  issues a single option  agreement  which  contains both
Incentive  Stock Options and  Non-Qualified  Stock Options,  the exercise of one
cannot affect the exercise of the other.

     3. Eligibility.  The persons who shall be eligible to receive options under
the Plan shall be Directors and those employees of the Company, or of any of its
parents  or  subsidiaries  within the  meaning of Section  424(e) and (f) of the
Code,  who are exempt from the overtime  provisions of the Fair Labor  Standards
Act of 1938, as amended, by reason of employment in an executive, administrative
or  professional  capacity under 29 U.S.C.  ss.  213(a)(1);  provided,  however,
Directors,  who  are not  employees  of the  Company  or any of its  parents  or
subsidiaries,  shall  not  be  eligible  to  receive  Incentive  Stock  Options.
Additionally,  no Incentive Stock Option shall be granted to a person who would,
at the time of the grant of such  option,  own, or be deemed to own for purposes
of Section  422(b)(6) of the Code,  more than 10% of the total  combined  voting
power of all  classes  of  shares  of stock of the  Company  or its  parents  or
subsidiaries  unless at the time of the grant of the Incentive Stock Option both
of the following conditions are met:

     (a) The  option  price is at least  110% of the  fair  market  value of the
shares of stock  subject to the Incentive  Stock  Option,  as defined in Section
4(a) hereof, and

     (b) the option is, by its terms,  not  exercisable  after the expiration of
five years from the date the Incentive Stock Option is granted.

     4. Shares Subject to Options.

     (a)  Subject to the  provisions  of Section  5(g)  hereof,  options  may be
granted  under the Plan to purchase  in the  aggregate  not more than  1,680,000
shares of the $.01 par value Common Stock of the Company  (hereinafter  referred
to as "Shares"),  which Shares may, in the discretion of the Committee,  consist
either in whole or in part of authorized  but unissued  Shares or Shares held in
the  treasury  of the  Company.  Any Shares  subject to an option  which for any
reason expires or is terminated  unexercised as to such Shares shall continue to
be available for options under the Plan.

     (b) To the extent the  aggregate  fair market  value,  determined as of the
time the option is granted,  of Shares for which stock  options are  exercisable
for the first time by such individual in any calendar year,  under all incentive
stock  option  plans of the Company or in any  corporation  which is a parent or
subsidiary of the Company,  exceeds  $100,000,  such options shall be treated as
Non-Qualified  Options.  However,  the value of the Shares  for which  Incentive
Stock Options may be granted to such individual from the Company in a given year
may exceed $100,000.

     5.  Terms and  Conditions  of  Options.  Options  shall be  granted  by the
Committee  pursuant to the Plan and shall be subject to the following  terms and
conditions:

     (a) Price.  Each  option  shall  state the number of Shares  subject to the
option and the option price,  which,  in the case of an Incentive  Stock Option,
shall be not less than the fair market value of the Shares with respect to which
the option is granted at the time of the  granting of the option.  In  addition,
the option  price shall be at least 110% of fair  market  value in the case of a
grant of an  Incentive  Stock  Option  to a person  who would at the time of the
grant,  own, or be deemed to own for purposes of Section  422(b)(6) of the Code,
more than 10% of the total combined voting power of all classes of Shares of the
Company or its parents or subsidiaries.  For purposes of this subsection,  "fair
market value" shall mean:

     (i) the mean between the bid and asked price for the Shares on the business
day immediately preceding the date of the grant of the option;

     (ii) the most  recent sale price for the Shares as of the date of the grant
of the option; or

     (iii) such price as shall be  determined  by the Board of  Directors of the
Company in an attempt  made in good  faith to meet the  requirements  of Section
422(b)(4) of the Code.

     (b) Term. The term of each option shall be determined by the Committee, but
in no event shall an option be exercisable  either in whole or in part after the
expiration  of ten years from the date on which it is  granted.  Notwithstanding
the foregoing, the Committee and an optionee may, by mutual agreement, terminate
any option  granted  to such  optionee  under the Plan.  In the event of merger,
consolidation,  dissolution or liquidation  which results in a change of control
as defined in Section 368(c) of the Code (using the attribution rules of Section
318), all unexercised  options will become immediately  exercisable for a period
of one year, the  effectiveness of such expiration shall be conditioned upon the
consummation of any such transaction.

     (c) Vesting.  The Committee shall determine the vesting  schedule,  if any,
for each  issuance of options  hereunder on a  case-by-case  basis,  in its sole
discretion.

     (d)  Non-Assignment  During Life. During the lifetime of the optionee,  the
option  shall  be  exercisable  only  by him  and  shall  not be  assignable  or
transferable  by him,  whether  voluntarily or by operation of law or otherwise,
and no other person shall acquire any rights therein.

     (e) Death of Optionee. In the event that an optionee shall die prior to the
complete  exercise  of  options  granted to him under the Plan,  such  remaining
options may be  exercised  in whole or in part after the date of the  optionee's
death only:  (i) by the  optionee's  estate or by or on behalf of such person or
persons to whom the optionee's rights under the option pass under the optionee's
Will or the  laws of  descent  and  distribution;  (ii) to the  extent  that the
optionee was entitled to exercise the option at the date of his death; and (iii)
prior to the expiration of the term of the option.

     (f)  Termination  of  Employment.   An  Incentive  Stock  Option  shall  be
exercisable  during the  lifetime of the optionee to whom it is granted only if,
at all times  during the period  beginning  on the date of the  granting  of the
option and ending on the day three months before the date of such  exercise,  he
is an  employee  of the  Company or any of its  parents or  subsidiaries,  or an
employee of a corporation or a parent or subsidiary of such corporation  issuing
or assuming an option granted hereunder in a transaction to which Section 424(a)
of the Code applies;  provided,  however, that in the case of an optionee who is
disabled  within the meaning of Section  22(e)(3)  of the Code,  the three month
period after  cessation  of  employment  during which an Incentive  Stock Option
shall be exercisable shall be one year. Notwithstanding the foregoing, no option
shall be exercisable  after the expiration of its term thereof.  For purposes of
this subsection, an employment relationship will be treated as continuing intact
while the optionee is on military  duty,  sick leave or other bona fide leave of
absence,  such as temporary employment by the Government,  if the period of such
leave does not exceed 90 days,  or, if longer,  so long as a statute or contract
guarantees the optionee's right to re-employment with the Company, or any of its
parents or subsidiaries,  or another  corporation  issuing or assuming an option
granted  hereunder in a transaction to which Section 424(a) of the Code applies.
When  the  period  of  leave  exceeds  90 days  and the  individual's  right  to
re-employment is not guaranteed either by statute or by contract, the employment
relationship will be deemed to have terminated on the 91st day of such leave.

     (g) Anti-Dilution  Provisions.  Subject to the provisions of Section 422 of
the Code and the regulations  promulgated  thereunder,  the aggregate number and
kind of Shares  available for options under the Plan, and the number and kind of
Shares  subject to, and the option  price of, each  outstanding  option shall be
proportionately  adjusted by the Committee for any increase,  decrease or change
in the total outstanding  Shares of the Company resulting from a stock dividend,
recapitalization,  merger,  consolidation,  combination,  exchange  of Shares or
similar  transaction (but not by reason of the issuance or purchase of Shares by
the Company in consideration for money, services or property).

     (h) Power to  Establish  Other  Provisions.  Subject to the  provisions  of
Section  422 of the Code and the  regulations  promulgated  thereunder,  options
granted  under the Plan shall  contain  such other terms and  conditions  as the
Committee shall deem advisable.

     6. Exercise of Option. Options shall be exercised as follows:

     (a) Notice and Payment.  Each option, or any installment thereof,  shall be
exercised,  whether in whole or in part, by giving written notice to the Company
at its  principal  office,  specifying  the number of Shares  purchased  and the
purchase price being paid, and accompanied by the payment of all or such part of
the purchase price as shall be specified in the option,  by cash or by certified
or bank check payable to the order of the Company.  If a registration  statement
covering the issuance of the Shares has not been filed under the  Securities Act
of 1933, as amended  (hereinafter  referred to as the "Act"), and at the time of
exercise is not effective and current in accordance with the requirements of the
Act,  then each such notice shall also contain  appropriate  representations  on
behalf of the optionee regarding,  among other things,  compliance with the Act,
available exemptions from registration,  investment intent and restrictions upon
resale of the Shares, as are deemed appropriate by the Company.

     Appropriate legends may be placed on any certificate for Shares received by
an optionee pursuant to the exercise of an option in order to give notice of the
transfer  restrictions set forth herein, and the Company may cause stop transfer
orders to be placed against such  certificates.  It shall be a further condition
to any exercise of the option and the purchase of Shares  pursuant  thereto that
the Company  counsel be  satisfied  that the  issuance of such shares will be in
compliance with the Act and any other laws applicable  thereto,  and the Company
shall be  entitled to receive  such other  information,  assurances,  documents,
representations  or warranties as it or its counsel may reasonably  require with
respect to such compliance.

     (b)  Issuance  of  Certificates.   Certificates   representing  the  Shares
purchased  by the  optionee  shall be  issued as soon as  practicable  after the
optionee has complied with the provisions of Section 6(a) hereof.

     (c)  Rights  as a  Shareholder.  The  optionee  shall  have no  rights as a
Shareholder  with respect to the Shares purchased until the date of the issuance
to him of a Certificate representing such Shares.

     (d)  Disposition  of Shares.  Subject  to the  provisions  of Section  6(a)
hereof,  any  disposition,  within the meaning of Section 424(c) of the Code, of
Shares  acquired by the exercise of an Incentive  Stock Option  within two years
from the date of grant of the option or within one year  after the  transfer  of
the Shares to the optionee  shall be a  disqualifying  disposition as defined in
Section  421(b) of the  Code;  provided,  however,  that the  foregoing  holding
periods  shall not  apply to the  disposition  of Shares  after the death of the
optionee by the estate of the  optionee,  or by a person who acquired the Shares
by  bequest  or  inheritance  or by  reason of the  death of the  optionee.  For
purposes of the  preceding  sentence,  in the case of a transfer of Shares by an
insolvent optionee to a trustee, receiver or similar fiduciary in any proceeding
under Title 11 of the United States Code or any similar  insolvency  proceeding,
neither the transfer,  nor any other  transfer of such Shares for the benefit of
his creditors in such proceeding, shall constitute a disposition.

     (e) Order of Option Exercise.  An optionee may exercise the options granted
by the Company  under the Plan in any order the optionee  chooses  regardless of
the chronological order in which the options were granted by the Company.

     7. Special  Provisions  Regarding Option Grants to Non-Employee  Directors.
Pursuant  to the  terms  of  this  Plan,  each  non-employee  Director  of  this
Corporation  shall be  entitled to receive a one-time  grant of a  Non-Qualified
Option,  effective  upon the date of his/her  initial  election  to the Board of
Directors of the Corporation,  to purchase 36,000 Shares. The exercise price for
such option shall equal the fair market value of the Corporation's  Common Stock
on the grant date. Each such option shall vest as to exercisability with respect
to the first 20% of the shares subject thereto on the first  anniversary date of
the grant date of such option, and as to an additional 20% of the shares subject
thereto on each of the second,  third, fourth and fifth anniversary dates of the
grant  date.  Any  such  options  granted  to  non-employee   Directors  of  the
Corporation  shall be exercisable only during the holder's term as a Director of
the Corporation, and shall automatically expire upon the date that a Director is
no longer serving as a Director,  except that an option may be exercisable after
the  death,   disability,   as  defined   in  Section   22(e)(3)   of  the  Code
("Disability"),  or  retirement  from the  Board at the age of 65 or  thereafter
("Retirement"),  of a holder  while a Director  of the Company at any time until
the  earlier  to  occur of (i) the one year  anniversary  of the date of  death,
Disability, or Retirement and (ii) the expiration of the term of such option. No
shares of Common  Stock  issuable  upon the  exercise  of an option may be sold,
assigned,  pledged or otherwise transferred for a period of six months after the
later to occur of (x) the adoption of the Plan by the Company's shareholders and
(y) the grant of the option,  as is  specified in Rule 16b-3 (or other period of
time  specified  in such rule as such rule may be amended  from time to time) of
the  Securities  Exchange Act of 1934, as amended (the  "Exchange  Act").  It is
intended  that  this  part  of the  Plan  as it  applies  to  option  grants  to
non-employee  Directors  will  constitute a "formula plan" within the meaning of
Rule 16b-3 under the  Exchange  Act, and the  provisions  of the Plan and of any
option  agreement  made  pursuant  to the Plan will be  interpreted  and applied
accordingly. At any time the Committee may suspend or terminate this part of the
Plan and make  such  additions  or  amendments  thereto  as it deems  advisable;
provided,  that such  additions or amendments  are made in compliance  with Rule
16b-3 of the Exchange  Act (as such rule may be amended from time to time);  and
provided,  further,  that the terms of this paragraph  shall not be amended more
than once every six months  (other than to comply  with the  federal  securities
laws, the Code, or ERISA).

     8. Term of Plan.  Options may be granted  pursuant to the Plan from time to
time  within a period of ten years  after  the date the Plan is  adopted  by the
Board of  Directors  of the  Company  or the date  the Plan is  approved  by the
holders of a majority of the outstanding  Shares of the Company,  whichever date
is  earlier.  However,  the Plan shall not take  effect  until  approved  by the
holders  of a  majority  of the  outstanding  Shares of the  Company,  at a duly
constituted meeting thereof,  held within 12 months before or after the date the
Plan is adopted by the Board of Directors.

     9.  Amendment and  Termination  of Plan.  The  Committee,  without  further
approval  of the  Shareholders  of the  Company,  may at  any  time  suspend  or
terminate the Plan,  or may amend it from time to time in any manner;  provided,
however,  that no amendment  shall be effective  without  prior  approval of the
Shareholders of the Company which would:  (i) except as provided in Section 5(g)
hereof,  increase the maximum  number of Shares for which options may be granted
under the  Plan;  (ii)  change  the  eligibility  requirements  for  individuals
entitled  to receive  options  under the Plan;  or (iii) cause  Incentive  Stock
Options  granted or to be granted under the Plan to fail to qualify as Incentive
Stock  Options  under  Section 422 of the Code and the  regulations  promulgated
thereunder.

     10.  Shares  Reserved.  The Board of Directors of the Company  shall at all
times  during the term of this Plan  reserve and keep  available  such number of
Shares as will be sufficient to satisfy the requirements of this Plan, and shall
pay all original issue taxes on the exercise of options,  and all other fees and
expenses necessarily incurred by the Company in connection therewith.

     11.  Application  of  Proceeds.  The  proceeds of the sale of Shares by the
Company under the Plan will  constitute  general funds of the Company and may be
used by the Company for any purpose.

Date approved by

Board of Directors - _______________

Shareholders - _____________________




                                                                     Exhibit 5.1

                                                     May 2, 2000

Patient Infosystems, Inc.
46 Prince Street
Rochester, New York 14607

Re:      Patient Infosystems, Inc.

Gentlemen:

     We have acted as counsel to Patient  Infosystems,  Inc. (the  "Company") in
connection  with all  proceedings  relating to the  authorization  and  proposed
issuance  and sale by you of shares of  common  stock,  $.01 par value per share
("Common  Stock") upon the exercise of stock options granted pursuant to Patient
Infosystems,  Inc.  Stock Option Plan, as amended (the "Plan"),  as described in
the Registration Statement on Form S-8 (the "Registration Statement"),  filed by
you with the  Securities  and Exchange  Commission  under the  Securities Act of
1933, as amended (the "Act").

     Based upon our  examination  of such  documents and  proceedings as we have
deemed necessary and pertinent, we are of the opinion that:

     1.  Patient  Infosystems,  Inc.  (the  "Company")  is  a  corporation  duly
organized and existing under the laws of the State of Delaware;

     2. The Plan has been duly authorized and approved by the Board of Directors
and the stockholders of the Company;

     3. The shares of Common  Stock  reserved by the Board of  Directors  of the
Company for issuance upon the exercise of stock  options  granted under the Plan
have been duly authorized; and

     4. When the shares of Common  Stock are  issued  upon the due  exercise  of
stock options  granted in accordance  with the Plan, such shares of Common Stock
will be duly and  validly  issued  and  outstanding  and will be fully  paid and
non-assessable.

     We hereby  consent  to the  filing of this  opinion  as an  exhibit  to the
Registration Statement.

Very truly yours,

/s/ Gibbons, Del Deo, Dolan, Griffinger & Vecchione
- ---------------------------------------------------
GIBBONS, DEL DEO, DOLAN, GRIFFINGER & VECCHIONE
A Professional Corporation




                                                                    Exhibit 23.1

                         CONSENT OF INDEPENDENT AUDITORS

     We consent to the incorporation by reference in this Registration Statement
of Patient  Infosystems,  Inc. on Form S-8 of our report dated  January 28, 2000
(March 21, 2000 as to Note 11 therein),  appearing in the Annual  Report of Form
10-K of Patient Infosystems, Inc. for the year ended December 31, 1999, which is
part of this Registration Statement.



Deloitte & Touche LLP
Rochester, New York
May 3, 2000


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