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<PAGE> 1
Filed Pursuant to Rule 424(b)(3)
Registration Statement No. 333-34075
Supplement
to
Prospectus dated September 22, 1997
The table of Selling Shareholders on pages 12, 13 and 14 is hereby
replaced in its entirety with the following table:
<TABLE>
<CAPTION>
Shares Shares of
Common Common
Stock Stock
Beneficially Shares Beneficially
Owned Prior Offered Owned After
to the Offering Hereby the Offering
--------------- ------- ------------
<S> <C> <C> <C>
NAME OF SHAREHOLDERS
Bruce Addis 151 151
Lourdes P. Aguda 29 29
Ellen Beaumont 124 124
Walter Blair 70,007 70,007
John E. Bramfitt and Pamela I. Bramfitt, 13,024 13,024
Co-Trustees FBO Bramfitt Family Trust
U/A/D/ 01/20/93
John H. Bunch 279 279
Jeffrey P. Callister 23,516 23,516
Laura Dietch 5,628 5,628
Catherine Diez-Luckie 24,862 24,862
Neal Eigler 252,469 252,469
Hartmut & Maria Eysell, JT TEN 1,123 1,123
Glenn K. Furuta 19,810 19,710 100
Mark D. Milani, Trusteee of the 22,528 22,528
Gabriela M. Hess Trust U/T/A/
dated November 30, 1994
Robert Hess and Rosemarie Hess, 584,298 584,298
Trustees FBO Hess Family Trust
U/A/D/ dated 8/3/89
Mark D. Milani, Trustee of the 22,528 22,528
Verona K. Hess 1994 Trust U/T/A/
dated November 30, 1994
William B. Hess 1,123 1,123
Jerome Jackson 8,201 8,201
Litvack-Curtis Children's Trust, 33,794 33,794
Robert Harabedian, Trustee
Frank Litvack 597,817 597,817
Judy Litvack Ravinsky 372 372
Yoh Chie Lu 8,758 8,758
Paul McCormick 8,445 8,445
Nathan Ramaswami 111 111
Lisa Rauh 28 28
Nancy Shanley 937 937
Fred Zuber 242 242
Fukuda Denshi Co., Ltd. 125,812 125,812
Arnhold & S. Bleichroeder, Inc. 803 803
(for Michelle Drasher)
Arnhold & S. Bleichroeder, Inc. 36,208 36,208
(for First Eagle Fund, NV)
Arnhold & S. Bleichroeder, Inc. 4,021 4,021
(for Gary Fuhrman)
Arnhold & S. Bleichroeder, Inc. 4,021 4,021
(for Harold Levy)
Stephen Aiello 600 600
AS Fansea 400 400
Howard Berlin 3,016 3,016
John Bohan 400 400
David L. Cohen 3,216 3,216
Bryan C. Donohue, M.D. 3,013 3,013
Michael Dovey 1,004 1,004
</TABLE>
<PAGE> 2
<TABLE>
<S> <C> <C> <C>
Paine Webber in Trust of the Jonathan Edelson IRA 803 803
Evelin Eigler, Trustee of the Seldon Baker Trust 1,003 1,003
Stuart M. Essig 1,004 1,004
John S. Geis 4,021 4,021
Claudio Gibelli 2,009 2,009
GSAM Oracle Fund, Inc. 24,139 24,139
Hare & Co. 26,149 26,149
William M. Helvey, M.D. 1,004 1,004
John B. Henneman, III 400 400
Steven Hochberg 803 803
Hoegh Invest AS 2,613 2,613
Alice Jack 1,004 1,004
Earl L. and Julia Ender Jackson 1,004 1,004
as Community Property
FBO Ronald P. Karlsberg Cardiovascular Group 900 600 300
of Southern California 401(k)
Profit Sharing Plan DTD 1/1/89
Gerald T. Keusch 600 600
Kurt H. Kruger 803 803
Jack Litvack, Cyst Investment Corp. 3,004 1,004 2,000
Patrick A. McBrayer 400 400
J. Casey McGlynn 159 159
David Moyne 803 803
David B. Musket 5,751 5,751
Cowen & Co., 904 904
Custodian FBO David B. Musket SEP IRA
August J. Neudecker 4,021 4,021
Och-Ziff Capital Management, L.P. 30,173 30,173
Daniel P. Paduano 3,016 3,016
Munro W. Pitt 601 601
ProMed Partners, L.P. 13,576 13,576
Prudential Securities 2,010 2,010
C/F Colin Morris A/C AA-R54811
Randall Rose 16,091 16,091
Clinton T. Rubin (SUNY - Stony Brook) 400 400
J. Curt Schnackenberg 1,004 1,004
Lorraine A. Schwarz 1,004 1,004
Dieter Stoeckel 559 359 200
Lawrence J, Tedesco, Sr. 440 440
The Travelers Indemnity Company 44,255 44,255
The Travelers Insurance Company 85,494 85,494
The Travelers Life and Annuity Company 5,025 5,025
The Phoenix Insurance Company 6,033 6,033
Westfield Performance Fund, L.P. 20,113 20,113
WS Investment Company 96A 1,445 1,445
James Whiting 537 537
Wilson, Sonsini, Goodrich & Rosati Profit Sharing 400 400
Plan, Mario M. Rosati and Douglas
M. Laurice, Trustees, FBO J. Casey McGlynn
Federico Gutierrez 84 84
David B. Modesitt 479 479
Sheldon King 3,377 3,377
Martin Leon M.D. 5,630 5,630
Paul Teirstein M.D. 2,816 2,816
Wood Grundy (London) Ltd. 138 138
Ashtree Corporation 1,807 1,807
Jim Lane 1,807 1,807
Paine Webber Inc., as custodian of the IRA 1,083 1,083
account of Jason F. Fensterstock
Paine Webber Inc., as custodian of the IRA 1,807 1,807
</TABLE>
<PAGE> 3
<TABLE>
<S> <C> <C> <C>
account of Joyce Fensterstock
Paine Webber Inc., as custodian of the IRA 903 903
IRA account of Blair Fensterstock
Richard Yancy 903 903
Stephen Case 903 903
Brad Stephens 540 540
Edward Kosinski 1,807 1,807
Janet Tweed-Arkush 540 540
Gary Schonwald 903 903
JIBJEB Partners 903 903
John Friedman 2,104 2,104
Steven Casey 470 470
Khalid Quadir 74 74
Edward Casey 540 540
Auldgate Investments 4,192 4,192
Adzich, Vaso 299 299
Avanzado, Jocelyn S. 74 74
Ayrapetian, Angela 130 130
Bachrach, Alan 1,124 1,124
Baldwin, Scott 1,800 1,800
Bauer, Laura L. 224 224
Calvarese, Barry 14,079 14,079
Chernomorsky, Ary S. 1,035 1,035
Cooper, Irvin 1,687 1,687
Elam, Eric W. 188 188
Forrester, M.D., James 7,884 7,884
Goldenberg, Tsvi 2,251 2,251
Hamamoto, Kiyoko 55 55
Hammack, Amy L. 279 279
Herd, Allison 261 261
Holmes, M.D., David 3,377 3,377
Khaira, Gurpreet 56 56
Krasney, Karen 575 575
Kuhn, Larry 1,687 1,687
Lin, Stuart H. 188 188
Madriz, Cecilia 94 94
Maharaj, Kishore 74 74
McCormic, Frank P. 289 289
McKenzie, Jim 1,703 1,703
Mendoza, Graciela Ortega 111 111
Meyer, Barry D. 580 580
Mrakovic, Iskra 154 154
Padron, Ana Maria 62 62
Park, Kinam 1,862 1,862
Pena, Uriel 88 88
Pinon, Hortensia 289 289
Ramzipoor, Kamal 1,912 1,912
Reitman, Martha 1,350 1,350
Steigler, Markus O. 317 317
Sudaria, Rodolfo 149 149
Surgener, David L. 224 224
Trinidad, Jocelyn 74 74
van der Zweep, Michael B. 1,034 1,034
Viravouth, Chandavone 74 74
Wilson, Sally J. 1,923 1,923
--------- --------- -----
Total: 2,281,621 2,279,021 2,600
========= ========= =====
</TABLE>
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