<PAGE> 1
Filed Pursuant to Rule 424(b)(3)
Registration Statement No. 333-34075
Supplement
to
Prospectus dated September 22, 1997
The table of Selling Shareholders on pages 12, 13 and 14 is hereby
replaced in its entirely with the following table:
<TABLE>
<CAPTION>
Shares Shares of
Common Common
Stock Stock
Beneficially Shares Beneficially
Owned Prior Offered Owned After
to the Offering Hereby the Offering
--------------------- ------------------ ------------------
<S> <C> <C> <C>
NAME OF SHAREHOLDERS
Bruce Addis 151 151 -
Lourdes P. Aguda 29 29 -
Ellen Beaumont 124 124 -
Walter Blair 94,716 94,716 -
John E. Bramfitt and Pamela I. Bramfitt, 12,961 12,961 -
Co-Trustees FBO Bramfitt Family Trust
U/A/D/ 01/20/93
John H. Bunch 279 279 -
Jeffrey P. Callister 23,401 23,401 -
Cedar-Sinai Medical Center 3,544 3,544 -
Laura Dietch 1,868 1,868 -
Catherine Diez-Luckie 26,051 26,051 -
Neal Eigler 251,216 251,216 -
Hartmut & Maria Eysell, JT TEN 1,119 1,119 -
Glenn K. Furuta 30,566 30,466 100
Mark D. Milani, Trusteee of the 22,418 22,418 -
Gabriela M. Hess Trust U/T/A/
dated November 30, 1994
Robert Hess and Rosemarie Hess, 581,396 581,396 -
Trustees FBO Hess Family Trust
U/A/D/ dated 8/3/89
Mark D. Milani, Trustee of the 22,418 22,418 -
Verona K. Hess 1994 Trust U/T/A/
dated November 30, 1994
William B. Hess 1,119 1,119 -
Jerome Jackson 8,161 8,161 -
Litvack-Curtis Children's Trust, 33,628 33,628 -
Robert Harabedian, Trustee
Frank Litvack 591,304 591,304 -
Judy Litvack Ravinsky 371 371 -
Yoh Chie Lu 8,717 8,717 -
Paul McCormick 14,303 14,303 -
</TABLE>
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<TABLE>
<S> <C> <C> <C>
Nathan Ramaswami 111 111 -
Lisa Rauh 28 28 -
Nancy Shanley 933 933 -
Fred Zuber 242 242 -
Fukuda Denshi Co., Ltd. 125,189 125,189 -
Arnhold & S. Bleichroeder, Inc. 800 800 -
(for Michelle Drasher)
Arnhold & S. Bleichroeder, Inc. 36,030 36,030 -
(for First Eagle Fund, NV)
Arnhold & S. Bleichroeder, Inc. 4,002 4,002 -
(for Gary Fuhrman)
Arnhold & S. Bleichroeder, Inc. 4,002 4,002 -
(for Harold Levy)
Stephen Aiello 599 599 -
AS Fansea 399 399 -
Howard Berlin 3,002 3,002 -
John Bohan 399 399 -
David L. Cohen 3,202 3,202 -
Bryan C. Donohue, M.D. 3,930 3,930 -
Michael Dovey 1,000 1,000 -
Paine Webber in Trust of the Jonathan Edelson IRA 800 800 -
Evelin Eigler, Trustee of the Seldon Baker Trust 999 999 -
Stuart M. Essig 1,000 1,000 -
John S. Geis 4,002 4,002 -
Claudio Gibelli 2,000 2,000 -
GSAM Oracle Fund, Inc. 24,020 24,020 -
Hare & Co. 26,021 26,021 -
William M. Helvey, M.D. 1,000 1,000 -
John B. Henneman, III 399 399 -
Steven Hochberg 800 800 -
Hoegh Invest AS 2,601 2,601 -
Alice Jack 1,000 1,000 -
Earl L. and Julia Ender Jackson 1,000 1,000 -
as Community Property
FBO Ronald P. Karlsberg Cardiovascular Group 899 599 300
of Southern California 401(k)
Profit Sharing Plan DTD 1/1/89
Gerald T. Keusch 599 599 -
Kurt H. Kruger 800 800 -
Jack Litvack, Cyst Investment Corp. 3,000 1,000 2,000
Patrick A. McBrayer 399 399 -
J. Casey McGlynn 159 159 -
David Moyne 800 800 -
David B. Musket 5,724 5,724 -
Cowen & Co., 900 900 -
Custodian FBO David B. Musket SEP IRA
August J. Neudecker 4,002 4,002 -
Och-Ziff Capital Management, L.P. 30,025 30,025 -
Daniel P. Paduano 3,002 3,002 -
</TABLE>
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<PAGE> 3
<TABLE>
<S> <C> <C> <C>
Munro W. Pitt 600 600 -
ProMed Partners, L.P. 13,510 13,510 -
Prudential Securities 2,001 2,001 -
C/F Colin Morris A/C AA-R54811
Randall Rose 16,013 16,013 -
Clinton T. Rubin (SUNY - Stony Brook) 399 399 -
J. Curt Schnackenberg 1,000 1,000 -
Lorraine A. Schwarz 1,000 1,000 -
Dieter Stoeckel 559 359 200
Lawrence J, Tedesco, Sr. 439 439 -
The Travelers Indemnity Company 44,036 44,036 -
The Travelers Insurance Company 85,071 85,071 -
The Travelers Life and Annuity Company 5,003 5,003 -
The Phoenix Insurance Company 6,004 6,004 -
Westfield Performance Fund, L.P. 20,016 20,016 -
WS Investment Company 96A 1,440 1,440 -
James Whiting 536 536 -
Wilson, Sonsini, Goodrich & Rosati Profit Sharing 399 399 -
Plan, Mario M. Rosati and Douglas
M. Laurice, Trustees, FBO J. Casey McGlynn
Federico Gutierrez 163 163
David B. Modesitt 1,305 1,305
Sheldon King 4,292 4,292
Martin Leon M.D. 7,153 7,153
Paul Teirstein M.D. 8,117 8,117
Wood Grundy (London) Ltd. 111 111 -
Ashtree Corporation 1,793 1,793 -
Jim Lane 1,793 1,793 -
Paine Webber Inc., as custodian of the IRA 1,075 1,075 -
account of Jason F. Fensterstock
Paine Webber Inc., as custodian of the IRA 1,793 1,793 -
account of Joyce Fensterstock
Paine Webber Inc., as custodian of the IRA 896 896 -
IRA account of Blair Fensterstock
Richard Yancy 896 896 -
Stephen Case 896 896 -
Brad Stephens 537 537 -
Edward Kosinski 1,793 1,793 -
Janet Tweed-Arkush 537 537 -
Gary Schonwald 896 896 -
JIBJEB Partners 896 896 -
John Friedman 2,102 2,102 -
Steven Casey 470 470 -
Khalid Quadir 74 74 -
Edward Casey 537 537 -
Auldgate Investments 4,192 4192 -
===================== ================== ==================
Total: 2,270,022 2,267,422 2,600
===================== ================== ==================
</TABLE>
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