WORLDWIDE HEALTH SCIENCES PORTFOLIO
N-8A/A, 1999-01-13
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM N-8A

                    AMENDMENT TO NOTIFICATION OF REGISTRATION

                      FILED PURSUANT TO SECTION 8(a) OF THE
                         INVESTMENT COMPANY ACT OF 1940


     The  undersigned  investment  company  hereby  amends its  notification  of
registration filed with the Securities and Exchange  Commission on July 22, 1996
pursuant to the provisions of Section 8(a) of the Investment Company Act of 1940
and in connection with such amendment to  notification  of registration  submits
the following information:

Name:    Worldwide Health Sciences Portfolio

Address of Principal Business Office:
         24 Federal Street
         Boston, MA  02110

Telephone Number:    (617) 482-8260

Name and address of agent for service of process:
         Alan R. Dynner
         24 Federal Street
         Boston, Massachusetts   02110


Check Appropriate Box:

     Registrant is filing a Registration  Statement  pursuant to Section 8(b) of
     the  Investment  Company Act of 1940  concurrently  with the filing of Form
     N-8A: YES [ ] NO [X]

Item 1.        Name of Registrant:  Worldwide Health Sciences Portfolio.

Item 2.        State and Date of Organization:  New York; March 26, 1996.

Item 3.        Form of Organization:  Trust.

Item 4.        Classification of Registrant:  Management Company.

Item 5(a).     Registrant is an open-end company.

Item 5(b).     Registrant is a diversified company.

Item 6.        Investment Adviser of Registrant: OrbiMed Advisors, Inc., 767 3rd
               Avenue, 6th floor, New York, NY 10017.
<PAGE>

Item 7.        Board of Trustees of Registrant:

                           Jessica M. Bibliowicz(1)
                           Donald R. Dwight(2)
                           James B. Hawkes*
                           Samuel L. Hayes, III(3)
                           Norton H. Reamer(4)
                           Lynn A. Stout(5)
                           John L. Thorndike(6)
                           Jack L. Treynor(7)

               Officers of Registrant:

                           President:                James B. Hawkes*
                           Vice President:           Samuel D. Isaly(8)
                           Secretary:                Alan R. Dynner*
                           Treasurer:                James L. O'Connor*
                           Assistant Secretary/
                              Assistant Treasurer:   Janet E. Sanders*
                           Assistant Treasurer:      Barbara E. Campbell*
                           Assistant Secretary:      A. John Murphy*
                           Assistant Secretary:      Eric G. Woodbury*

               The address for each of the above-named  Trustees and Officers of
               Registrant is as follows: (1) One Rockefeller Plaza, New York, NY
               10020;  (2) Clover  Mill Lane,  Lyme,  NH 04768;  (3) 345 Nahatan
               Street,  Westwood, MA 02090; (4) One International Place, Boston,
               MA 02110;  (5) Georgetown  University Law Center,  600 New Jersey
               Avenue, NW, Washington,  DC 20001; (6) 10 Main Street,  Dover, MA
               02030; (7) 504 Via Almar, Palos Verdes Estates, CA 90274; (8) 767
               3rd Avenue,  6th floor,  New York, NY 10017;  *24 Federal Street,
               Boston, MA 02110.

Item 8.        Inapplicable.

Item 9(a).     No;   Registrant  is  not  currently  issuing  and  offering  its
               securities directly to the public.

Item 9(b).     Inapplicable.

Item 9(c).     No;  Registrant  does  not  presently  propose  to make a  public
               offering of its securities.

Item 9(d).     Yes.

Item 9(e).     As of December 31,  1998,  there were four  beneficial  owners of
               Registrant's outstanding securities. As of December 31, 1998, the
               following   investors  held  10%  or  more  of  the   outstanding
               securities  of  the  Registrant:  Eaton  Vance  Worldwide  Health
               Sciences Fund - 99.8%.  No other  Holders of Interests  held more
               than 10% of the  Registrant's  outstanding  securities as of that
               date.

Item 10.       Current Value of Registrant's Total Assets:  $206,243,024

Item 11.       No.

Item 12.       Registrant   incorporates   by  reference  the  August  31,  1998
               financial  statements as previously filed electronically with the
               Commission    on    November    4,    1998     (Accession     No.
               0000950109-98-004915).
<PAGE>



                                    SIGNATURE

     Pursuant to the  requirements  of the  Investment  Company Act of 1940, the
Registrant has caused this amendment to  Notification of Registration to be duly
signed on its behalf in the City of Boston and  Commonwealth of Massachusetts on
the 11th day of January, 1999.


                           WORLDWIDE HEALTH SCIENCES PORTFOLIO


                           By: /s/ James B. Hawkes
                               -----------------------
                               James B. Hawkes
                               President

Attest: /s/ Janet E. Sanders
        -------------------------
        Janet E. Sanders
        Assistant Secretary


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