CN BIOSCIENCES INC
S-8, 1996-11-21
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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<PAGE>
    As filed with the Securities and Exchange Commission on November 21, 1996

                                                     Registration No. 333-

================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                              ---------------------
                                    Form S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                              ---------------------
                              CN Biosciences, Inc.
             (Exact name of registrant as specified in its charter)
            Delaware                                           33-0509785
  (State or other jurisdiction                              (I.R.S. Employer
of incorporation or organization)                          Identification No.)
                              ---------------------
                           10394 Pacific Center Court
                           San Diego, California 92121
                                 (619) 450-5500
               (Address, including zip code, and telephone number,
                 including area code, of registrant's principal
                               executive offices)
                              ---------------------
        CN Biosciences, Inc. Amended and Restated 1992 Stock Option Plan
                            (Full title of the plan)
                              ---------------------
                                James G. Stewart
              Vice President, Chief Financial Officer and Secretary
                              CN Biosciences, Inc.
                           10394 Pacific Center Court
                           San Diego, California 92121
                                 (619) 450-5500
             (Name, address, including zip code and telephone number
                   including area code, of agent for service)
                              ---------------------
                                 with copies to:
                              Peter H. Jakes, Esq.
                            Willkie Farr & Gallagher
                               One Citicorp Center
                              153 East 53rd Street
                            New York, New York 10022
                                 (212) 821-8000

<TABLE>
                                         CALCULATION OF REGISTRATION FEE
<CAPTION>

==========================================================================================================

Title of Each Class of Securities  Amount to be    Proposed Maximum     Proposed Maximum      Amount of
       to be Registered(1)         Registered(1)    Offering Price     Aggregate Offering    Registration
                                                    per Share (2)          Price (2)             Fee

<S>                                   <C>              <C>              <C>                   <C>
==========================================================================================================

Common Stock, $.01 par value          753,473          $17.875          $13,468,329.87        $4,081.31
==========================================================================================================
</TABLE>

(1)  Represents  the  shares  of  Common  Stock  issuable  pursuant  to  the  CN
     Biosciences,  Inc.  Amended  and  Restated  1992  Stock  Option  Plan.
(2)  Calculated  pursuant  to Rule 457(c) and (h) on the basis of the average of
     the high and low prices of the Common Stock as reported on the Nasdaq Stock
     Market on November 19, 1996.


================================================================================



<PAGE>

                                     PART II

                           INFORMATION REQUIRED IN THE
                             REGISTRATION STATEMENT

Item 3.  INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

         The  following  documents,  filed  with  the  Securities  and  Exchange
Commission (the  "Commission") by CN Biosciences,  Inc., a Delaware  corporation
(the "Company"), are incorporated by reference into this Registration Statement:
(a) the Prospectus that was part of the Company's Registration Statement on Form
S-1 (Registration No. 333-8335),  which Prospectus was filed with the Commission
on October 2, 1996 pursuant to Rule 424(b) under the  Securities Act of 1933, as
amended (the "Securities Act"); (b) the Company's  Quarterly Report on Form 10-Q
for the  quarter  ended  September  30,  1996;  and (c) the  description  of the
Company's Common Stock contained in the Company's Registration Statement on Form
8-A filed with the Commission, and any amendment or report filed for the purpose
of updating such description.

         All documents filed by the Company  pursuant to Sections 13(a),  13(c),
14 and 15(d) of the Securities  Exchange Act of 1934, as amended,  subsequent to
the date of this  Registration  Statement and prior to the  termination  of this
offering of securities  shall be deemed to be incorporated  by reference  herein
and to be a part  hereof  from  the  date  of the  filing  of such  reports  and
documents.  Any statement  contained in a document  incorporated or deemed to be
incorporated  by reference  herein shall be deemed to be modified or  superseded
for  purposes  of this  Registration  Statement  to the extent  that a statement
contained herein or in any other subsequently filed document which also is or is
deemed to be  incorporated  by  reference  herein  modifies or  supersedes  such
statement.  Any such  statement so modified or  superseded  shall not be deemed,
except as so modified or superseded,  to constitute a part of this  Registration
Statement.


Item 4.  DESCRIPTION OF SECURITIES

         Inapplicable.

Item 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         Inapplicable.

Item 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         The Company's  Amended and Restated  Certificate of Incorporation  (the
"Certificate of  Incorporation")  provides that the Company shall indemnify each
person who is or was a director or officer of the Company to the fullest  extent
permitted  under  the  Delaware  General  Corporation  Law.  Section  145 of the
Delaware  General  Corporation Law empowers a Delaware  corporation to indemnify
any  person  who was or is a party  or is  threatened  to be made a party to any
threatened,  pending or completed  action,  suit or  proceeding,  whether civil,
criminal,  administrative  or  investigative  (other than an action by or in the
right of such  corporation)  by reason of the fact that such  person is or was a
director,  officer, employee or agent of such corporation,  or is or was serving
at the request of such corporation as a director,  officer, employee or agent of
another  corporation  or  enterprise.  A corporation  may indemnify  such person
against expenses (including attorneys' fees), judgments,  fines and amounts paid
in settlement actually and reasonably incurred by such person in connection with
such  action,  suit or  proceeding  if he acted in good faith and in a manner he
reasonably  believed  to be in or not  opposed  to  the  best  interests  of the
corporation,  and,  with respect to any criminal  action or  proceeding,  had no
reasonable  cause to believe his conduct was  unlawful.  A  corporation  may, in
advance of the final  disposition  of any  civil,  criminal,  administrative  or
investigative action, suit or proceeding, pay the expenses (including attorneys'
fees)  incurred by any officer or director in defending  such  action,  provided
that the  director  or  officer  undertakes  to repay  such  amount  if it shall
ultimately  be  determined  that he is not  entitled  to be  indemnified  by the
corporation.



<PAGE>


         A Delaware  corporation may also indemnify officers and directors in an
action by or in the right of the  corporation to procure a judgment in its favor
under the same conditions,  except that no  indemnification is permitted without
judicial  approval  if the  officer or  director is adjudged to be liable to the
corporation.  Where an  officer  or  director  is  successful  on the  merits or
otherwise in the defense of any action referred to above,  the corporation  must
indemnify him against the expenses (including attorneys' fees) which he actually
and reasonably incurred in connection therewith. The indemnification provided is
not deemed to be  exclusive  of any other rights to which an officer or director
may  be  entitled  under  any  corporation's   by-laws,   agreements,   vote  of
stockholders or disinterested directors or otherwise.

         The  Certificate  of  Incorporation  provides  that a  director  of the
Company will not be  personally  liable to the Company or its  stockholders  for
monetary  damages  for  breach  of  fiduciary  duty as a  director,  except  for
liability (i) for any breach of the director's duty of loyalty to the Company or
its stockholders,  (ii) for acts or omissions not in good faith or which involve
intentional misconduct or a knowing violation of law, (iii) under Section 174 of
the Delaware  General  Corporation  Law,  which  concerns  unlawful  payments of
dividends, stock purchases or redemptions or (iv) for any transaction from which
the director derived an improper personal benefit.

         While  the  Certificate  of  Incorporation   provides   directors  with
protection from awards for monetary  damages for breaches of their duty of care,
it does not eliminate such duty.  Accordingly,  the Certificate of Incorporation
will  have no  effect  on the  availability  of  equitable  remedies  such as an
injunction  or  rescission  based on a  director's  breach of his or her duty of
care. The provisions of the Certificate of  Incorporation  described above apply
to an officer of the Company  only if he or she is a director of the Company and
is acting in his or her  capacity as  director,  and do not apply to officers of
the Company who are not directors.

         The  Company's  Amended and Restated  By-Laws  provide that the Company
shall indemnify any and all of its directors or officers,  who shall serve as an
officer or director of the Company or of any other corporation at the request of
the Company,  to the fullest extent  permitted  under and in accordance with the
laws of the State of Delaware.

         The Company has entered into indemnification agreements with certain of
its   directors   and   officers   pursuant  to  which  the   Company   provides
indemnification and contribution against expenses and losses incurred for claims
brought  against  them by reason of their  being an officer or  director  of the
Company.  Members of the Stock Option  Committee  of the Board of Directors  are
also indemnified by the Company in connection with their  administration  of the
Amended and Restated 1992 Stock Option Plan. The Company  maintains a directors'
and officers' liability insurance policy.

         Joseph P.  Landy and S.  Joshua  Lewis,  nominees  of  Warburg,  Pincus
Investors, L.P. ("Warburg") to the Company's Board of Directors, are entitled to
indemnification by Warburg for liabilities incurred as a result of their service
as directors of the Company.


Item 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Inapplicable.


<PAGE>





Item 8.  EXHIBITS

Exhibit Number             Description of Document
- --------------             -----------------------

     5                     Opinion of Willkie Farr & Gallagher
     23.1                  Consent of Ernst & Young LLP, Independent Auditors
     23.2                  Consent of Willkie  Farr &  Gallagher  (included
                             in their  opinion  filed as  Exhibit 5 hereto)
     24                    Powers of Attorney (included on the signature
                             page hereto)
     99                    CN Biosciences, Inc. Amended and Restated
                             1992 Stock Option Plan

Item 9.  UNDERTAKINGS

        (a)  The undersigned Registrant hereby undertakes:

        (1) To file during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:

            (i)  To  include any  prospectus  required by section  10(a)(3) of
the Securities Act.

            (ii) To reflect in the  prospectus any facts or events arising after
        the  effective  date of the  registration  statement (or the most recent
        post-effective   amendment  thereof)  which,   individually  or  in  the
        aggregate,  represent a fundamental  change in the information set forth
        in  the  registration  statement.  Notwithstanding  the  foregoing,  any
        increase  or  decrease  in volume of  securities  offered  (if the total
        dollar  value of  securities  offered  would not  exceed  that which was
        registered)  and any deviation from the low or high end of the estimated
        maximum  offering range may be reflected in the form of prospectus filed
        with the Commission  pursuant to Rule 424(b) if, in the  aggregate,  the
        changes in volume and price  represent no more than a 20 percent  change
        in the maximum aggregate offering price set forth in the "Calculation of
        Registration Fee" table in the effective registration statement.

            (iii) To include any material  information  with respect to the plan
        of distribution not previously  disclosed in the registration  statement
        or  any  material  change  to  such   information  in  the  registration
        statement;

            Provided,  however,  that paragraphs (1)(i) and (1)(ii) above do not
        apply if the  information  required to be  included in a  post-effective
        amendment by those  paragraphs  is contained in periodic  reports  filed
        with or  furnished  to the  Commission  by such  registrant  pursuant to
        section 13 or section 15(d) of the Securities  Exchange Act of 1934 (the
        "Exchange Act") that are  incorporated by reference in the  registration
        statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         (b) The undersigned  registrant hereby undertakes that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Exchange Act (and, where  applicable,  each filing of an employee benefit plan's
annual  report   pursuant  to  Section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.


<PAGE>



         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant  to the  foregoing  provision,  or  otherwise,  the
registrant  has  been  advised  that  in  the  opinion  of the  Commission  such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.


<PAGE>




                                   SIGNATURES

         Pursuant to the  requirements  of the  Securities  Act, the  Registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of San Diego, State of California, on November 21, 1996.


                                   CN BIOSCIENCES, INC.


                                   By: /s/ James G. Stewart
                                       --------------------------------------
                                       Name:  James G. Stewart
                                       Title: Vice President, Chief Financial
                                                Officer and Secretary



                                POWER OF ATTORNEY

         Each of the undersigned officers and directors of CN Biosciences,  Inc.
hereby severally  constitutes and appoints Stelios B.  Papadopoulos and James G.
Stewart, and each of them as the attorneys-in-fact  for the undersigned,  in any
and all  capacities,  with  full  power  of  substitution,  to sign  any and all
amendments to this  Registration  Statement,  and to file the same with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange  Commission,  granting unto said  attorneys-in-fact,  and each of them,
full  power  and  authority  to do and  perform  each and  every  act and  thing
requisite and  necessary to be done in and about the  premises,  as fully to all
intents and  purposes as he might or could do in person,  hereby  ratifying  and
confirming all that each said attorney-in-fact,  or either of them, may lawfully
do or cause to be done by virtue hereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

<TABLE>
<CAPTION>

         Signature                            Title                                Date
         ---------                            -----                                ----

<S>                               <C>                                          <C>

/s/ Stelios B. Papadopoulos       Chairman of the Board of Directors,          November 21, 1996
- ---------------------------       Chief Executive Officer and
Stelios B. Papadopoulos           President
                                  (Principal executive officer)

/s/ James G. Stewart              Vice President, Chief Financial              November 21, 1996
- ---------------------------       Officer and Secretary
James G. Stewart                  (Principal financial and
                                  accounting officer)


/s/ Frederick L. Bryant           Director                                     November 21, 1996
- ---------------------------
Frederick L. Bryant




<PAGE>





/s/ Joseph P. Landy               Director                                     November 21, 1996
- ---------------------------
Joseph P. Landy


/s/ S. Joshua Lewis               Director                                     November 21, 1996
- ---------------------------
S. Joshua Lewis

/s/ Robert E. McGill, III         Director                                     November 21, 1996
- ---------------------------
Robert E. McGill, III
</TABLE>







<PAGE>



                                INDEX TO EXHIBITS


Exhibit Number             Description of Document
- --------------             -----------------------

      5                    Opinion of Willkie Farr & Gallagher
      23.1                 Consent of Ernst & Young LLP, Independent Auditors
      23.2                 Consent of Willkie  Farr &  Gallagher
                             (included  in their  opinion  filed as  Exhibit 5
                             hereto)
      24                   Powers of Attorney (included on the signature
                             page hereto)
      99                   CN Biosciences, Inc. Amended and Restated 1992
                             Stock Option Plan



<PAGE>

                                                                     Exhibit 5

                            Willkie Farr & Gallagher
                              One Citicorp Center
                              153 East 53rd Street
                            New York, New York 10022




November 21, 1996



CN Biosciences, Inc.
10394 Pacific Center Court
San Diego, CA 92121

Ladies and Gentlemen:

We are delivering this opinion in connection with the Registration Statement on
Form S-8 (the "Registration Statement") filed by CN Biosciences, Inc. (the
"Company") on November 21, 1996, with the Securities and Exchange Commission
under the Securities Act of 1933, as amended (the "Act"), with respect to
753,473 shares (the "Shares"), par value $.01 per share, of common stock of the
Company (the "Common Stock"). The Shares are issuable upon the exercise of stock
options granted and to be granted to participants (the "Participants") under the
CN Biosciences, Inc. Amended and Restated 1992 Stock Option Plan (the "Plan").

We have examined and are familiar with originals or copies, certified or
otherwise identified to our satisfaction, of such documents, corporate records
and other instruments, and have made such investigations of law, as we have
deemed necessary and advisable. In such examination, we have assumed the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals and the conformity to authentic originals of all documents
submitted to us as copies.

Based upon the foregoing, we are of the opinion that:

     The Shares have been duly authorized and, when issued, delivered and sold
     by the Company and paid for by the Participants pursuant to the terms of
     the Plan for consideration in excess of $.01 per share, will be validly
     issued, fully paid and non-assessable shares of Common Stock of the
     Company.


<PAGE>


CN Biosciences, Inc.
November 21, 1996
Page 2


We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement referred to above. We do not admit by giving this consent
that we are in the category of persons whose consent is required under Section 7
of the Act.

Very truly yours,



/s/ Willkie Farr & Gallagher










<PAGE>
                                                                 Exhibit 23.1


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in the Registration Statement on
Form S-8 pertaining to the Amended and Restated 1992 Stock Option Plan of CN
Biosciences, Inc. of our reports dated July 16, 1996, with respect to the
consolidated financial statements and schedule of CN Biosciences, Inc. included
in its Registration Statement on Form S-1, filed with the Securities and
Exchange Commission.

                                                             ERNST & YOUNG LLP



San Diego, California
November 18, 1996



<PAGE>
                                                                      Exhibit 99


                              CN BIOSCIENCES, INC.
                  AMENDED AND RESTATED 1992 STOCK OPTION PLAN

                                     * * *

                                   ARTICLE I

                                    Purpose
                                    -------

         The CN Biosciences, Inc. Amended and Restated 1992 Stock Option Plan
(the "Plan") is intended as an incentive to improve the performance, encourage
the continued employment, and increase the proprietary interest of certain
directors, officers, key employees and consultants of CN Biosciences, Inc. (the
"Company") and its subsidiaries who shall participate in the Plan. The Plan is
designed to grant such directors, officers, key employees and consultants the
opportunity to share in the Company's long-term success through stock ownership
and to afford them the opportunity for additional compensation related to the
value of the Company's stock.

         The word "Employer", when used in the Plan, shall include the Company
or one of its subsidiaries, whichever one employs the Participant. The word
"subsidiary", when used in the Plan, shall mean any subsidiary corporation of
the Company within the meaning of Section 424(f) of the Internal Revenue Code of
1986, as amended (the "Code").

         It is intended that certain options granted under the Plan and
designated as incentive stock options in the option agreements qualify as
"incentive stock options" under Section 422 of the Code.

         For purposes of the Plan, the term "Effective Date" shall mean April 1,
1992.

                                   ARTICLE II

                                 Administration
                                 --------------

         The Plan shall be administered by a Stock Option Committee (the
"Committee") appointed by the Board of Directors of the Company (the "Board")
from among its members and shall consist of not less than two members thereof.
Unless otherwise determined by the Board, the membership of the Committee shall
be structured so as to qualify option grants for the exemption from Section
16(b) of the Securities Exchange Act of 1934 (the "Exchange Act") provided by
Rule 16b-3, promulgated by the Securities and Exchange Commission under the
Exchange Act, as in effect from time to time.



<PAGE> 2


         Subject to the provisions of the Plan, the Committee shall have sole
authority, in its absolute discretion: (a) to determine which of the eligible
Participants (as hereinafter defined) shall be granted options; (b) to authorize
the granting of both incentive stock options and non-qualified stock options;
(c) to determine the times when options shall be granted and the number of
shares to be subject to options; (d) to determine the option price of the shares
subject to each option, which price shall be not less than the minimum specified
in ARTICLE V; (e) to determine the time or times when each option becomes
exercisable, the duration of the exercise period and any other restrictions on
the exercise of options issued hereunder; (f) to accelerate the exercisability
of any outstanding option; (g) to prescribe the form or forms of the option
agreements under the Plan (which forms shall be consistent with the terms of the
Plan but need not be identical and may contain such terms as the Committee may
deem appropriate to carry out the purposes of the Plan); (h) to determine the
nature of any rights and restrictions to be imposed on shares subject to options
issued hereunder; (i) to adopt, amend and rescind such rules and regulations as,
in its opinion, may be advisable in the administration of the Plan; (j) to
construe and interpret the Plan, the option agreements under the Plan and the
rules and regulations adopted from time to time, if any; and (k) to make all
other determinations deemed necessary or advisable for the administration of the
Plan. All decisions, determinations and interpretations of the Committee shall
be final and binding on all optionees.

                                  ARTICLE III

                                     Stock
                                     -----

         The stock to be subject to options granted under the Plan shall be
shares of authorized but unissued common stock, par value $0.01 (the "Stock"),
of the Company, or previously issued shares of such Stock reacquired by the
Company and held in its treasury, as determined by the Board. Under the Plan,
the total number of shares of Stock which may be purchased pursuant to options
granted hereunder shall not exceed, in the aggregate, 835,000 shares, except as
such number of shares shall be adjusted in accordance with the provisions of
ARTICLE X hereof.

         Each option granted under the Plan shall be evidenced by an option
agreement between the Company and the optionee containing such provisions as may
be determined by the Committee, but shall be subject to the following terms and
conditions:

         (a) Each share of Stock purchased through the exercise of an option
shall be paid for in full at the time of the exercise; and

         (b) Each option shall become exercisable by the optionee in accordance
with any vesting schedule established by the Committee pursuant to ARTICLE VI of
the Plan.

<PAGE> 3


         The number of shares of Stock available for grant of options under the
Plan shall be decreased by the sum of the number of shares with respect to which
options have been issued and are then outstanding and the number of shares
issued upon exercise of options. In the event that any outstanding option for
any reason expires, lapses, or is canceled prior to the end of the period during
which options may be granted, the shares of Stock called for by the unexercised
portion of such option may again be subject to an option under the Plan.

                                   ARTICLE IV

                          Eligibility of Participants
                          ---------------------------

         Subject to ARTICLE VII, directors, officers, key employees and
consultants of the Company and its subsidiaries who have been selected by the
Committee as participants (collectively referred to as "Participants" and
individually as a "Participant") shall be eligible to receive grants of options
under the Plan; provided, however, that notwithstanding any other provision of
the Plan to the contrary, only employees of the Company or any of its
subsidiaries shall be eligible to receive incentive stock options. Participation
in the Plan shall be limited to eligible Participants who have entered into
option agreements with the Company. No Participant, however, shall at any time
have a right to be selected for participation in the Plan.

                                   ARTICLE V

                                  Option Price
                                  ------------

         The option price of each option granted under the Plan shall be
determined by the Committee; provided, however, that in the case of each
incentive stock option granted under the Plan, the option price shall not be
less than the fair market value at the time the option is granted. In no event
shall the option price of any option be less than the par value per share of
Stock on the date an option is granted.

         At any time when the Stock is quoted on the National Association of
Securities Dealers Automated Quotation System ("NASDAQ"), the fair market value
shall be deemed to be the mean between the last quoted bid and asked prices on
NASDAQ on the date immediately preceding the date on which the option is
granted, or, if not quoted on that day, then on the last preceding date on which
such stock is quoted. If the Stock is listed on one or more national securities
exchanges, the fair market value shall be deemed to be the mean between the
highest and lowest sale prices reported on the principal national
securities exchange on which such stock is listed and traded on the date
immediately preceding the date on which the option is granted, or, if there is
no such sale on that date, then on the last preceding date on which such a sale
was reported. If the

<PAGE> 4

Stock is not quoted on NASDAQ or listed on an exchange, or representative quotes
are not otherwise available, the fair market value of the Stock shall mean the
amount determined by the Committee to be the fair market value based upon a good
faith attempt to value the Stock accurately and computed in accordance with
applicable regulations of the Internal Revenue Service.

                                   ARTICLE VI

                        Terms and Conditions of Options
                        -------------------------------

         Options granted under the Plan shall vest and become exercisable in
such installments as the Committee shall determine at the time of grant. Options
may be exercisable in whole or in part and if an option is exercisable in part,
the portion thereof which is exercisable and not exercised shall remain
exercisable.

         Any other provision of the Plan notwithstanding and subject to ARTICLE
VII, (i) no option shall be granted after the date which is ten years from the
Effective Date, (ii) no option may be exercised after the date which is ten
years after the date that the option was granted (the "Termination Date"), and
(iii) in the event the Company files a registration statement under the
Securities Act of 1933 (the "Securities Act") for the initial public offering of
its equity securities (an "IPO"), the Company may restrict the exercisability of
options granted under the Plan during the 180-day period (or such longer period
required by the underwriter of such initial public offering) immediately
following the effective date of such registration statement.

         Options granted hereunder may provide that if prior to the Termination
Date an optionee shall cease to be employed by the Employer for any reason other
than death, disability or for cause, the option will remain exercisable by the
optionee for a period not extending beyond three months after the date of
cessation of employment, but in no event later than the Termination Date, to the
extent it was exercisable at the time of cessation of employment. Options
granted hereunder may provide that if prior to the Termination Date an optionee
shall cease to be employed by the Employer for reasons of death or disability,
the option will remain exercisable by the optionee or, in the event of his
death, by the person or persons to whom the optionee's rights under the option
would pass by will or the applicable laws of descent and distribution for a
period not extending beyond one year after the date of death or disability, but
in no event later than the Termination Date, to the extent it was exercisable at
the time of death or disability. Options granted hereunder may provide that if
prior to the Termination Date an optionee shall cease to be employed by the
Employer by reason of termination of employment by the Employer for cause, or by
voluntary termination at a time when the Employer is entitled to terminate such
optionee's employment for cause, the option shall terminate immediately. For
purposes of the Plan, the Employer shall have "cause" to terminate an optionee's
employment

<PAGE> 5



hereunder upon (i) the commission by the optionee of a proven act of fraud or
embezzlement against the Employer, (ii) the engaging by the optionee in willful
misconduct or gross negligence which is demonstrably and materially injurious to
the Employer, monetarily or otherwise, (iii) failure of the optionee to render
services to the Employer in accordance with such optionee's duties as an
employee of the Employer or (iv) the optionee being convicted of a misdemeanor
involving an act of moral turpitude or a felony. Alternatively, options granted
hereunder may provide that "cause" has the meaning set forth in an employment
agreement between the optionee and the Employer.

         For purposes of the Plan, in the case of a Participant who is a
director, references to employment herein shall be deemed to refer to such
director's service to the Employer in such capacity.

         Notwithstanding the foregoing, stock options granted hereunder shall
provide that no option shall be exercisable after the optionee's cessation of
employment with the Employer if at the time of exercise the By-Laws of the
Company limit the ownership of common stock of the Company to selected persons,
including employees of the Company and its wholly-owned subsidiaries.

                                  ARTICLE VII

                         Special Provisions Applicable
                        Only to Incentive Stock Options
                        -------------------------------

         To the extent the aggregate fair market value (determined at the time
the option is granted) of the Stock with respect to which incentive stock
options may be exercisable for the first time by an optionee during any calendar
year (under this Plan and any other stock option plan of the Company and any
parent or subsidiary thereof) exceeds $100,000, such incentive stock options
shall be treated as options which are non-qualified stock options.

         No incentive stock option may be granted to an individual who, at the
time the option is granted, owns directly, or indirectly within the meaning of
Section 424(d) of the Code, stock possessing more than 10% of the total combined
voting power of all classes of stock of the Company or of any parent or
subsidiary thereof, unless such option (i) has an option price of at least 110%
of the fair market value of the Stock on the date of the grant of such option;
and (ii) such option by its terms cannot be exercised more than five years after
the date it is granted.

         Each optionee who receives an incentive stock option must agree to
notify the Company in writing immediately after the optionee makes a
disqualifying disposition of any Stock acquired pursuant to the exercise of an
incentive stock option. A

<PAGE> 6




disqualifying disposition is any disposition (including any sale) of such Stock
before the later of (a) two years after the date the optionee was granted the
incentive stock option or (b) one year after the date the optionee acquired
Stock by exercising the incentive stock option.

                                  ARTICLE VIII

                               Payment for Shares
                               ------------------

         Payment for shares of Stock acquired pursuant to an option granted
hereunder shall be made in full, upon exercise of the option, in immediately
available funds in United States dollars, by certified or bank cashier's check.
Payment may also be made by any other method established by the Committee
including, without limitation, the tendering of previously owned shares of Stock
which have been held for at least six months, or pursuant to procedures for
cashless "broker-assisted" exercises approved by the Committee. Payment in full
shall include payment of any amounts required under paragraph (b) of ARTICLE
XIX.

                                   ARTICLE IX

                 Non-Transferability of Option Rights and Stock
                 ----------------------------------------------

         During the lifetime of the optionee, the option shall be exercisable
only by the optionee. No option shall be transferable, except by will or the
laws of descent and distribution.

                                   ARTICLE X

                 Adjustment for Recapitalization, Merger, Etc.
                 ---------------------------------------------

         The aggregate number of shares of Stock which may be purchased or
acquired pursuant to options granted hereunder, the number of shares of Stock
covered by each outstanding option and the price per share thereof in each such
option shall be appropriately adjusted for any increase or decrease in the
number of outstanding shares of Stock resulting from a stock split or other
subdivision or consolidation of shares of Stock or for other capital adjustments
or payments of stock dividends or distributions or other increases or decreases
in the outstanding shares of Stock effected without receipt of consideration by
the Company. Any adjustment shall be conclusively determined by the Committee.

        If the Company shall be the surviving corporation in any merger or
reorganization or other business combination, any option granted hereunder shall
cover the securities or other property to which a holder of the number of shares
of Stock covered by the unexercised portion of the option would have been
entitled pursuant to the terms of the merger. Upon any merger or reorganization
or other business combination in which the Company

<PAGE> 7



shall not be the surviving corporation, or a dissolution or liquidation of the
Company, or a sale of all or substantially all of the Company's assets, all
outstanding options shall terminate; provided, however, that the Company shall
cause either (i) the optionees to be paid an amount equal to the difference
between (A) the aggregate fair market value (determined in accordance with
ARTICLE V of the Plan) of the Stock subject to options held by the optionees at
the time of such transaction and (B) the aggregate exercise price of such
options, or (ii) the surviving or resulting corporation to grant the optionees
substitute options to purchase its shares on such terms and conditions, both as
to the number of shares and otherwise, which the Committee shall deem
appropriate.

         Stock option agreements under the Plan may, at the discretion of the
Committee, provide that upon stockholder approval of a merger, reorganization or
other business combination, whether or not the Company is the surviving
corporation, or a sale of all or substantially all of the Company's assets, all
unmatured installments of the options shall vest and become immediately
exercisable in full.

         The foregoing adjustments and the manner of application of the
foregoing provisions, including the issuance of any substitute options, shall be
determined by the Committee in its sole discretion. Any such adjustment may
provide for the elimination of any fractional share which might otherwise become
subject to an option.

                                   ARTICLE XI

                        No Obligation to Exercise Option
                        --------------------------------

         Granting of an option shall impose no obligation on the recipient to
exercise such option.

                                  ARTICLE XII

                                Use of Proceeds
                                ---------------

         The proceeds received from the sale of Stock pursuant to the Plan shall
be used for general corporate purposes.

                                  ARTICLE XIII

                            Rights as a Stockholder
                            -----------------------

         An optionee shall have no rights as a stockholder with respect to any
share covered by his option until such person shall have become the holder of
record of such share, and such person shall not be entitled to any dividends or
distributions or other rights in respect of such share for which the record date
is prior to the date on which such person shall have become the



<PAGE> 8

holder of record thereof, except as otherwise provided in ARTICLE X.

                                  ARTICLE XIV

                               Employment Rights
                               -----------------

         No provision in the Plan or in any option granted hereunder shall
confer on any optionee any right to continue in the employ of the Company, or to
interfere in any way with the right of the Company to terminate the optionee's
employment at any time.

                                   ARTICLE XV

                              Compliance with Law
                              -------------------

         The Company is relieved from any liability for the non-issuance or
non-transfer or any delay in the issuance or transfer of any shares of Stock
subject to options under the Plan which results from the inability of the
Company to obtain, or from any delay in obtaining, from any regulatory body
having jurisdiction or authority, any requisite approval to issue or transfer
any such shares if counsel for the Company deems such approval necessary for
lawful issuance or transfer thereof.

         Each option granted under the Plan is subject to the requirement that
if at any time the Board determines, in its discretion, that the listing,
registration or qualification of shares of Stock issuable upon exercise of
options is required by any securities exchange or under any state or Federal
law, or that the consent or approval of any governmental regulatory body is
necessary or desirable as a condition of, or in connection with, the grant of
options or the issuance of shares of Stock, no shares of Stock shall be issued,
in whole or in part, unless such listing, registration, qualification, consent
or approval has been effected or obtained free of any conditions or with such
conditions as are acceptable to the Board.

                                  ARTICLE XVI

                            Cancellation of Options
                            -----------------------

         The Committee, in its discretion, may, with the consent of any
optionee, cancel any outstanding option hereunder.

                                 ARTICLE XVII

                    Effective Date; Expiration Date of Plan
                    ---------------------------------------

         The Plan shall become effective upon adoption by the Company's Board of
Directors and approval by the stockholders of the Company in a manner which
complies with both Rule 16b-3 under the Exchange Act and Section 422(b)(1) of
the Code and the

<PAGE> 9



Treasury Regulations thereunder. The expiration date of the Plan, after which no
option may be granted hereunder, shall be the tenth anniversary of the later of
(i) adoption of the Plan by the Board of Directors or (ii) the approval of the
Plan by the stockholders of the Company pursuant to the previous sentence.

                                 ARTICLE XVIII

                      Amendment or Discontinuance of Plan
                      -----------------------------------

         The Board may terminate, amend or modify the Plan in its sole
discretion at any time or from time to time after the Effective Date.
Notwithstanding the preceding provisions of this ARTICLE XVIII, no such action
shall, without shareholder approval, increase the number of shares as to which
options may be granted under the Plan.

                                  ARTICLE XIX

                                 Miscellaneous
                                 -------------

         (a) Options shall be evidenced by option agreements (which need not be
identical) in such forms as the Committee may from time to time approve. Such
agreements shall conform to the terms and conditions of the Plan and may provide
that the grant of any option under the Plan and Stock acquired pursuant to the
Plan shall also be subject to such other conditions (whether or not applicable
to the option or Stock received by any other optionee) as the Committee
determines appropriate, including without limitation, provisions to assist the
optionee in financing the purchase of Stock through the exercise of options,
provisions for the forfeiture of, or restrictions on, resale or other
disposition of shares under the Plan, provisions giving the Company the right to
repurchase shares acquired under the Plan in the event the participant elects to
dispose of such shares, and provisions to comply with Federal and state
securities laws and Federal and state income tax withholding requirements.

         (b) The Company may, in its discretion, require that an optionee pay to
the Company, at the time of exercise, such amount as the Company deems necessary
to satisfy its obligations to withhold Federal, state, or local income or other
taxes incurred by reason of the exercise or the transfer of shares thereupon.

         (c) Each optionee shall file with the Committee a written designation
of one or more persons as beneficiary, who shall be entitled to exercise options
which are exercisable, if any, or to receive shares of Stock distributable, if
any, under the Plan upon the optionee's death. An optionee may, from time to
time, revoke or change his beneficiary designation without the consent of any
prior beneficiary by filing a new designation with the Committee. The last such
designation received by the Committee shall be controlling; provided, however,
that no designation, or change or revocation thereof, shall be effective

<PAGE> 10

unless received by the Committee prior to the optionee's death, and in no event
shall it be effective as of a date prior to such receipt.

         (d) If the Committee shall find that any person to whom any amount is
payable under the Plan is unable to care for his affairs because of illness or
accident, or is a minor, or has died, then any payment due to such person or his
estate (unless a prior claim therefor has been made by a duly appointed legal
representative), may, if the Committee so directs the Company, be paid to his
spouse, child, relative, an institution maintaining or having custody of such
person, or any other person deemed by the Committee to be a proper recipient on
behalf of such person otherwise entitled to payment. Any such payment shall be a
complete discharge of the liability of the Committee and the Company therefor.

         (e) No member of the Committee shall be personally liable by reason of
any contract or other instrument executed by such member or on his behalf in his
capacity as a member of the Committee nor for any mistake of judgment made in
good faith, and the Company shall indemnify and hold harmless each member of the
Committee and each other employee, officer or director of the Company to whom
any duty or power relating to the administration or interpretation of the Plan
may be allocated or delegated, against any cost or expense (including counsel
fees) or liability (including any sum paid in settlement of a claim) arising out
of any act or omission to act in connection with the Plan unless arising out of
such person's own fraud or bad faith; provided, however, that approval of the
Board shall be required for the payment of any amount in settlement of a claim
against any such person. The foregoing right of indemnification shall not be
exclusive of any other rights of indemnification to which such persons may be
entitled under the Company's Certificate of Incorporation or By-Laws, as a
matter of law, or otherwise, or any power that the Company may have to indemnify
them or hold them harmless.

         (f) The Plan shall be governed by and construed in accordance with the
internal laws of the State of Delaware without reference to the principles of
conflicts of law thereof.

         (g) No provision of the Plan shall require the Company, for the purpose
of satisfying any obligations under the Plan, to purchase assets or place any
assets in a trust or other entity to which contributions are made or otherwise
to segregate any assets, nor shall the Company maintain separate bank accounts,
books, records or other evidence of the existence of a segregated or separately
maintained or administered fund for such purposes. Optionees shall have no
rights under the Plan other than as unsecured general creditors of the Company,
except that insofar as they may have become entitled to payment of additional
compensation by performance of services, they shall have the same rights as
other employees under general law.

<PAGE> 11


         (h) Each member of the Committee and each member of the Board shall be
fully justified in relying, acting or failing to act, and shall not be liable
for having so relied, acted or failed to act in good faith, upon any report made
by the independent public accountant of the Company and upon any other
information furnished in connection with the Plan by any person or persons other
than such member.

         (i) Except as otherwise specifically provided in the relevant plan
document, no payment under the Plan shall be taken into account in determining
any benefits under any pension, retirement, profit-sharing, group insurance or
other benefit plan of the Company.

         (j) The expenses of administering the Plan shall be borne by the
Company.

         (k) Masculine pronouns and other words of masculine gender shall refer
to both men and women.

                                     * * *

As Amended and Restated
by the Board of Directors
of CN Biosciences, Inc. on
November 13, 1996









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