CN BIOSCIENCES INC
10-Q, 1998-08-14
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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<PAGE>   1

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

(Mark One)
[X]     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
        EXCHANGE ACT OF 1934

        FOR THE QUARTERLY PERIOD ENDED JUNE 30, 1998
                                       OR

[ ]     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
        SECURITIES EXCHANGE ACT OF 1934

        FOR THE TRANSITION PERIOD FROM _____ TO _____

                        COMMISSION FILE NUMBER 000-21281

                              CN BIOSCIENCES, INC.
             (Exact name of registrant as specified in its charter)

DELAWARE                                                     33-0509785
- --------                                                     ----------
(State or other jurisdiction of                              (I.R.S. Employer
incorporation or organization)                               Identification No.)

10394 PACIFIC CENTER COURT, SAN DIEGO, CA                    92121
- -----------------------------------------                    -----
(Address of principal executive offices)                     (Zip Code)

Registrant's telephone number, including area code:          (619) 450-5500
                                                             --------------

                                       N/A
                                       ---
              (Former name, former address and former fiscal year,
                          if changed since last report)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant
was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes (X) No ( )

Indicate the number of shares of each of the issuer's classes of common stock,
as of the latest practicable date:

Class                                                        August 9, 1998
- -----                                                        --------------

Common Stock, $.01 Par Value                                 5,699,905



<PAGE>   2

                              CN BIOSCIENCES, INC.
                               INDEX TO FORM 10-Q



<TABLE>
<S>                                                                                  <C>
PART I.  FINANCIAL INFORMATION

Item 1. Financial Statements

        Condensed Consolidated Balance Sheets as of June 30, 1998
        (unaudited) and December 31, 1997                                             3

        Condensed Consolidated Statements of Income for the Three Months
        and Six Months Ended June 30, 1998 and 1997 (unaudited)                       4

        Condensed Consolidated Statements of Cash Flows for the Six Months
        Ended June 30, 1998 and 1997 (unaudited)                                      5

        Notes to Interim Condensed Consolidated Financial Statements (unaudited)      6

Item 2. Management's Discussion and Analysis of Financial Condition
        and Results of Operations                                                     7

Item 3. Quantitative and Qualitative Disclosures About Market Risk                   16


PART II.  OTHER INFORMATION

Item 4. Submission of Matters to a Vote of Security Holders                          17

Item 6. Exhibits and Reports on Form 8-K                                             17

SIGNATURES

INDEX OF EXHIBITS
</TABLE>





                                       2
<PAGE>   3

PART I.  FINANCIAL INFORMATION

Item 1.  Financial Statements

                              CN BIOSCIENCES, INC.
                      CONDENSED CONSOLIDATED BALANCE SHEETS


<TABLE>
<CAPTION>
                                                         JUNE 30, 1998    DECEMBER 31, 1997
                                                         -------------    -----------------
                                                          (UNAUDITED)          (Note)
<S>                                                      <C>                <C>         
ASSETS

Current assets:
    Cash, cash equivalents and short-term                                              
    investments                                          $  5,571,000       $ 17,692,000
    Accounts receivable, net                                8,039,000          5,914,000
    Inventories                                            19,800,000         18,309,000
    Other current assets                                    3,090,000          2,800,000
                                                         ------------       ------------
Total current assets                                       36,500,000         44,715,000

Property and equipment, net                                 4,786,000          4,528,000
Intangible assets, net                                      9,909,000         10,330,000
Other assets                                                1,667,000            838,000
                                                         ------------       ------------
Total assets                                             $ 52,862,000       $ 60,411,000
                                                         ============       ============

LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts payable, trade                                $  2,608,000       $  2,505,000
  Liability for purchase of business                               --         10,500,000
  Accrued expenses                                          2,986,000          3,898,000
  Other current liabilities                                 1,729,000            837,000
                                                         ------------       ------------
Total current liabilities                                   7,323,000         17,740,000

Other liabilities                                           3,493,000          3,565,000

Stockholders' equity:
  Common stock                                                 57,000             56,000
  Additional paid-in capital                               43,276,000         42,481,000
  Accumulated deficit                                        (505,000)        (3,043,000)
  Foreign currency translation adjustment                    (782,000)          (388,000)
                                                         ------------       ------------
Total stockholders' equity                                 42,046,000         39,106,000
                                                         ------------       ------------
Total liabilities and stockholders' equity               $ 52,862,000       $ 60,411,000
                                                         ============       ============
</TABLE>


See accompanying notes.


Note:   The balance sheet at December 31, 1997 has been derived from the audited
        consolidated financial statements at that date, but does not include all
        of the disclosures required by generally accepted accounting principles.





                                       3
<PAGE>   4

                              CN BIOSCIENCES, INC.
                   CONDENSED CONSOLIDATED STATEMENTS OF INCOME
                                   (UNAUDITED)


<TABLE>
<CAPTION>
                                  THREE MONTHS ENDED JUNE 30,    SIX MONTHS ENDED JUNE 30,
                                      1998           1997          1998           1997
                                  -----------    -----------    -----------    -----------
<S>                               <C>            <C>            <C>            <C>        
Sales                             $13,064,000    $10,206,000    $25,546,000    $19,791,000
Cost of sales                       5,852,000      4,530,000     11,497,000      8,890,000
                                  -----------    -----------    -----------    -----------
Gross profit                        7,212,000      5,676,000     14,049,000     10,901,000
Operating expenses:
  Selling, general and
     administrative                 4,213,000      3,578,000      8,426,000      7,049,000
  Research and development            843,000        614,000      1,693,000      1,236,000
                                  -----------    -----------    -----------    -----------
Total operating expenses            5,056,000      4,192,000     10,119,000      8,285,000
                                  -----------    -----------    -----------    -----------
Income from operations              2,156,000      1,484,000      3,930,000      2,616,000
Interest income, net                   33,000        128,000         78,000        244,000
                                  -----------    -----------    -----------    -----------
                                                                                          
Income before income taxes          2,189,000      1,612,000      4,008,000      2,860,000
Provision for income taxes            798,000        550,000      1,470,000        988,000
                                  -----------    -----------    -----------    -----------
     Net income                   $ 1,391,000    $ 1,062,000    $ 2,538,000    $ 1,872,000
                                  ===========    ===========    ===========    ===========
Net income per share
     Basic                        $       .25    $       .20    $       .45    $       .35
                                  ===========    ===========    ===========    ===========
     Diluted                      $       .24    $       .19    $       .43    $       .33
                                  ===========    ===========    ===========    ===========
Shares used in per share
  computations
     Basic                          5,671,000      5,426,000      5,662,000      5,294,000
                                  ===========    ===========    ===========    ===========
     Diluted                        5,886,000      5,726,000      5,874,000      5,626,000
                                  ===========    ===========    ===========    ===========
</TABLE>








See accompanying notes.





                                       4
<PAGE>   5

                              CN BIOSCIENCES, INC.
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                   (UNAUDITED)


<TABLE>
<CAPTION>
                                                    SIX MONTHS ENDED JUNE 30,
                                                    1998               1997
                                                ------------       ------------
<S>                                             <C>                <C>         
OPERATING ACTIVITIES
Net income                                      $  2,538,000       $  1,872,000
Adjustments to reconcile net income to net
    cash used in operations:
  Depreciation and amortization                    1,438,000          1,171,000
  Additions to inventory reserve                     220,000            180,000
  Changes in assets and liabilities:
     Accounts receivable, trade                   (2,298,000)        (2,165,000)
     Inventories                                  (1,923,000)        (1,403,000)
     Other current assets                           (306,000)           176,000
     Other assets                                 (1,766,000)          (333,000)
     Accounts payable, trade                         173,000            253,000
     Accrued expenses                               (839,000)           383,000
     Other current liabilities                       921,000           (594,000)
     Other liabilities                               114,000           (190,000)
                                                ------------       ------------
Net cash used in operating activities             (1,728,000)          (650,000)

INVESTING ACTIVITIES
Purchases of property and equipment                 (800,000)          (705,000)
Purchase of business                             (10,500,000)                --
Other                                               (300,000)                --
                                                ------------       ------------
Net cash used in investing activities            (11,600,000)          (705,000)

FINANCING ACTIVITIES
Proceeds from the sale of common stock             1,245,000          3,491,000
                                                ------------       ------------
Net cash provided by financing activities          1,245,000          3,491,000

Effect of exchange rate changes on cash
  equivalents                                        (38,000)          (107,000)
                                                ------------       ------------
Net increase (decrease) in cash and
  cash equivalents                               (12,121,000)         2,029,000

Balance at beginning of period                    17,692,000         14,704,000
                                                ------------       ------------
Balance at end of period                        $  5,571,000       $ 16,733,000
                                                ============       ============
Supplemental cash flow information:
  Interest paid during the period               $     31,000       $     53,000
                                                ============       ============
  Income taxes paid during the period           $    102,000       $    875,000
                                                ============       ============
</TABLE>



See accompanying notes.





                                       5

<PAGE>   6

                              CN BIOSCIENCES, INC.
          NOTES TO INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                   (UNAUDITED)


        1. BASIS OF PRESENTATION

        The interim unaudited condensed consolidated financial statements of CN
Biosciences, Inc. (the "Company") contained herein have been prepared in
accordance with generally accepted accounting principles for interim financial
information. Accordingly, they do not include all of the information and
footnotes required by generally accepted accounting principles for complete
financial statements. These consolidated financial statements should be read in
conjunction with the consolidated financial statements and notes thereto for the
year ended December 31, 1997 included in the Company's Annual Report on Form
10-K filed with the Securities and Exchange Commission. In management's opinion,
the unaudited information includes all adjustments (consisting only of normal
recurring adjustments) necessary for a fair presentation of the financial
position, results of operations and cash flows for the periods presented.
Interim results are not necessarily indicative of results to be expected for the
full year.

        2. NEW ACCOUNTING STANDARDS

        Effective January 1, 1998, the Company adopted the Financial Accounting
Standards Board's Statement No. 130, Comprehensive Income, ("SFAS 130"), and
Statement No. 131, Disclosures about Segments of an Enterprise and Related
Information ("SFAS 131"). SFAS 130 establishes new rules for the reporting and
display of comprehensive income and its components, however, the adoption of
SFAS 130 had no impact on the Company's net income or stockholder's equity. SFAS
130 requires the change in the foreign currency translation adjustment be
included in comprehensive income. As adjusted for this item, comprehensive
income is $2,290,000 and $1,459,000 for the six-month periods ended June 30,
1998 and 1997, and $1,297,000 and $1,037,000 for the three-month periods ended
June 30, 1998 and 1997. SFAS 131 establishes standards for the way that public
business enterprises report information about operating segments in annual
financial statements and requires that those enterprises report selected
information about operating segments in interim financial reports. SFAS 131 also
establishes standards for related disclosures about products and services,
geographic areas and major customers. The adoption of SFAS 131 did not affect
results of operations or financial position, and did not affect the disclosure
of segment information because SFAS 131 is not required to be applied to interim
financial statements in the initial year of adoption.

        3. PUBLIC OFFERING

        In April 1997, the Company effected a public offering of 1,150,000
shares of common stock, par value $.01 per share, at $13.50 per share. The
offering consisted of 910,190 shares sold by one of the Company's founding
stockholders and 239,810 newly issued shares sold by the Company. The Company
raised gross proceeds of $3,237,000 before underwriters' commissions and
expenses. Proceeds from the offering will be used for general corporate purposes
and possible future acquisitions. Pending such uses, proceeds will be invested
in high-quality investment-grade securities of short maturity consistent with
the Company's investment policy.

        4. INVENTORIES

        Inventories consist of the following:

<TABLE>
<CAPTION>
                                                          June 30, 1998     December 31, 1997
                                                          -------------     -----------------
        <S>                                                <C>                <C>         
        Finished products                                  $ 16,222,000       $ 15,542,000
        Semi-finished products, raw materials and             6,696,000          6,056,000
        supplies
        Work-in-progress                                        668,000            517,000
                                                           ------------       ------------
                                                             23,586,000        22,115,000
        Reserves for excess materials                        (3,786,000)        (3,806,000)
                                                           ------------       ------------
             Total                                         $ 19,800,000       $ 18,309,000
                                                           ============       ============
</TABLE>





                                       6
<PAGE>   7

Item 2.

                     MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                  FINANCIAL CONDITION AND RESULTS OF OPERATIONS


        OVERVIEW

        The Company was formed in 1992 with the purchase of the Company's
subsidiaries, including the Calbiochem biochemical and immunochemical operations
headquartered in San Diego, California, and the Novabiochem peptide operations
headquartered in Laufelfingen, Switzerland, from Biodor Holding AG, Ixora
Holding AG and Biodor US Holding Corporation.

        In August 1995, the Company expanded its immunochemical and molecular
biology capabilities with the purchase of the Oncogene Research Products
business from Oncogene Science, Inc. (now know as OSI Pharmaceuticals, Inc. ,
"OSI") for $6.2 million cash, which was funded by bank debt. The acquisition and
successful integration of this business enhanced the depth and breadth of the
Company's scientific resources, while providing a complementary base of products
and customers.

        In December 1997, the Company expanded its molecular biology
capabilities with the purchase of all of the outstanding capital stock of
Novagen, Inc. ("Novagen"), a privately owned company, together with all of the
outstanding capital stock of its parent holding company, for a purchase price of
$10.5 million cash. Assets acquired included receivables and inventory, and
intangible assets including in-process technology valued at $6.8 million, which
was written off effective as of the purchase date. The acquisition of this
business further broadened the Company's product line and added an important
brand identity in molecular biology.

        The Company uses general and specialty catalogs to market a broad range
of brand-name research products to life sciences researchers worldwide at
pharmaceutical and biotechnology companies, academic institutions and government
laboratories. The Company invests significantly in producing each of its
catalogs, and associated costs are capitalized and amortized over the estimated
useful life of the catalog, generally 12 to 24 months.

        Since 1993, the Company has increasingly focused its strategy on its
higher margin core business of providing standard laboratory quantity sizes of
products (generally ranging from 100 nanograms to 100 grams), and has reduced
the focus on its bulk business. Bulk quantities (generally up to ten kilograms)
are generally offered at discounts to catalog prices, and bulk sales are
characterized as relatively high dollar sales made to a limited number of
customers. Thus, the absence or presence of bulk sales has had and could have a
material impact on results of operations in any individual period.

        The Company maintains significant levels of inventory relative to its
net sales in order to meet short delivery times required by researchers. In
addition, products manufactured internally are made in economic batch sizes
which often represent quantities sufficient to supply more than one year of
sales. The Company's products generally have a relatively long shelf life, often
in excess of five years, and quality and storage conditions are continually
monitored to ensure that quality products are delivered to customers. The
Company regularly evaluates the level and composition of inventory through the
analysis of recent sales history and forecasted product demand to ensure that
inventory reserve levels are adequate to properly reflect their net realizable
value. Recent fluctuations in inventory reserve levels have not been material to
the Company's financial position or results of operations.

        The Company's reporting currency is the U.S. dollar. Historically, a
majority of the Company's sales have been denominated in U.S. dollars, with the
balance denominated in foreign currencies. These foreign currency sales have
been effected principally by the Company's international subsidiaries. In
accordance with U.S. accounting requirements, sales denominated in foreign
currencies are translated into the local functional currency and then into U.S.
dollars, at an average exchange rate in effect during the period. In addition,
the Company incurs manufacturing costs in Swiss Francs in connection with its
Swiss operations





                                       7
<PAGE>   8

and also incurs operating expenses in local currencies at each of its other
international locations. Thus, changes from reporting period to reporting period
in the exchange rates between various foreign currencies and the U.S. dollar
have had, and will in the future continue to have, an impact on revenues and
expenses reported by the Company, and such effect may be material in any
individual reporting period. To the extent that the Company incurs operating
expenses in local currencies at its foreign subsidiaries, the Company has a
natural hedge against a portion of the possible fluctuation in foreign currency
exchange rates of billings in such currencies. Although the Company does not
engage in significant amounts of foreign currency hedging transactions, the
Company has, from time to time, entered into forward contracts to hedge certain
of its foreign currency exposures, principally related to fixed expense
commitments of its Japanese subsidiary. Additionally, the balance sheets of the
Company's international subsidiaries are translated into U.S. dollars and
consolidated with the balance sheets of the Company's domestic entities in
accordance with U.S. accounting requirements. Changes in the U.S. dollar value
of the foreign currency denominated assets are accounted for as an adjustment to
stockholders' equity. Therefore, changes from reporting period to reporting
period in the exchange rates between various foreign currencies and the U.S.
dollar have had, and will continue to have an impact on the foreign currency
translation component of stockholders' equity reported by the Company, and such
effect may be material in any individual reporting period.


        RESULTS OF OPERATIONS

        The following table sets forth, for the periods indicated, items from
the Company's Condensed Consolidated Statements of Income expressed as a
percentage of sales.

<TABLE>
<CAPTION>
                                                           PERCENTAGE OF SALES
                                                     THREE MONTHS         SIX MONTHS
                                                    ENDED JUNE 30,      ENDED JUNE 30,
                                                    1998      1997      1998      1997
                                                   -----     -----     -----     -----
        <S>                                        <C>       <C>       <C>       <C>  
        Sales:
          Core                                      80.0%     82.4%     81.6%     83.0%
          Bulk                                      20.0      17.6      18.4      17.0
                                                   -----     -----     -----     -----
        Total sales                                100.0     100.0     100.0     100.0
        Cost of sales                               44.8      44.4      45.0      44.9
                                                   -----     -----     -----     -----
        Gross profit                                55.2      55.6      55.0      55.1
          Selling, general and administrative       32.2      35.1      33.0      35.6
          Research and development                   6.5       6.0       6.6       6.2
                                                   -----     -----     -----     -----
        Income from operations                      16.5      14.5      15.4      13.3
        Interest income, net                         0.3       1.3       0.3       1.2
                                                   -----     -----     -----     -----
        Income before income taxes                  16.8      15.8      15.7      14.5
        Provision for income taxes                   6.2       5.4       5.8       5.0
                                                   -----     -----     -----     -----
             Net income                             10.6%     10.4%      9.9%      9.5%
                                                   =====     =====     =====     =====
</TABLE>






                                       8
<PAGE>   9


        Three Months Ended June 30, 1998 Compared to the Three Months Ended June
30, 1997

        Sales. Sales increased 28.0% to $13.1 million for the three-month period
ended June 30, 1998 from $10.2 million for the comparable period in 1997. This
increase resulted from a 24.2% increase in core product sales, and a 45.7%
increase in bulk sales. These gains in sales were made despite the general
strengthening of the U.S. dollar which had the effect of decreasing the dollar
value of sales denominated in foreign currencies recorded in the three-month
period ended June 30, 1998. The increase in core product sales included the
sales of Novagen, Inc., which was acquired in December, 1997. Additional factors
which management believes contributed to the increase in sales during the period
include increased orders from the Company's recently introduced specialty
catalogs and updated general catalogs, and other marketing initiatives,
including advertising in various publications.

        Gross Profit. The Company's gross profit percentage decreased to 55.2%
for the three-month period ended June 30, 1998 from 55.6% for the comparable
period in 1997. This decrease resulted primarily from the increased level of
lower margin bulk sales in the current period, offset by an increase in sales of
higher margin core products (including the Novagen products) and improved
operating efficiencies from increased volume and selected price increases.

        Selling, General and Administrative. Selling, general and administrative
expenses increased 17.7% to $4.2 million for the three-month period ended June
30, 1998 from $3.6 million for the comparable period in 1997, but decreased to
32.2% of sales for the current period from 35.1% for the comparable period in
1997. The dollar increase in selling, general and administrative expenses was
primarily the result of incremental costs related to the Novagen business,
increased administrative salaries and selling costs related to expanded
advertising programs and additional general and specialty catalogs. The decrease
in selling, general and administrative expenses as a percentage of sales was
attributable to the increased level of sales.

        Research and Development. Research and development expenses increased
37.3% to $843,000 for the three-month period ended June 30, 1998 from $614,000
for the comparable period in 1997, and increased to 6.5% of sales for the
current period from 6.0% for the comparable period in 1997. The increase in
research and development expenses was primarily the result of incremental costs
related to the Novagen business, and increased research in the niche areas of
neurosciences and glycobiology.

        Interest income. Interest income decreased to $33,000 for the
three-month period ended June 30, 1998 from $128,000 for the comparable period
in 1997. The decrease resulted from decreased cash balances as a result of the
completion of the Novagen acquisition.

        Income Taxes. Income tax expense increased to $798,000 for the
three-month period ended June 30, 1998 from $550,000 for the comparable period
in 1997. The increase resulted from increased profitability and increased
estimated tax rates due to utilization of certain operating loss carryforwards
in prior years.

        Net Income. As a result of the above factors, net income increased 31.0%
to $1,391,000 for the three-month period ended June 30, 1998 from $1,062,000 for
the comparable period in 1997.


        Six Months Ended June 30, 1998 Compared to the Six Months Ended June 30,
1997

        Sales. Sales increased 29.1% to $25.5 million for the six-month period
ended June 30, 1998 from $19.8 million for the comparable period in 1997. This
increase resulted from a 27.0% increase in core product sales and a 39.2%
increase in bulk sales. These gains in sales were made despite the general
strengthening of the U.S. dollar which had the effect of decreasing the dollar
value of sales denominated in foreign currencies recorded in the six-month
period ended June 30, 1998. The increase in core product sales included the
sales of Novagen, Inc., which was acquired in December, 1997. Additional factors
which management believes contributed to the increase in sales during the period
include increased orders from the Company's recently introduced specialty
catalogs and updated general catalogs, and other marketing initiatives,
including advertising in various publications.





                                       9
<PAGE>   10

        Gross Profit. The Company's gross profit percentage decreased slightly
to 55.0% for the six-month period ended June 30, 1998 from 55.1% for the
comparable period in 1997. This decrease resulted primarily from the increased
level of lower margin bulk sales in the current period.

        Selling, General and Administrative. Selling, general and administrative
expenses increased 19.5% to $8.4 million for the six-month period ended June 30,
1998 from $7.0 million for the comparable period in 1997, but decreased to 33.0%
of sales for the current period from 35.6% for the comparable period in 1997.
The dollar increase in selling, general and administrative expenses was
primarily the result of incremental costs related to the Novagen business,
increased administrative salaries and selling costs related to expanded
advertising programs and additional general and specialty catalogs. The decrease
in selling, general and administrative expenses as a percentage of sales was
attributable to the increased level of sales.

        Research and Development. Research and development expenses increased
37.0% to $1.7 million for the six-month period ended June 30, 1998 from $1.2
million for the comparable period in 1997, and increased to 6.6% of sales for
the current period from 6.2% for the comparable period in 1997. The increase in
research and development expenses was primarily the result of incremental costs
related to the Novagen business, and increased research in the niche areas of
neurosciences and glycobiology.

        Interest income. Interest income decreased to $78,000 for the six-month
period ended June 30, 1998 from $244,000 for the comparable period in 1997. The
decrease resulted from decreased cash balances as a result of the completion of
the Novagen acquisition.

        Income Taxes. Income tax expense increased to $1.5 million for the
six-month period ended June 30, 1998 from $1.0 million for the comparable period
in 1997. The increase resulted from increased profitability and increased
estimated tax rates due to utilization of certain operating loss carryforwards
in prior years.

        Net Income. As a result of the above factors, net income increased 35.6%
to $2.5 million for the six-month period ended June 30, 1998 from $1.9 million
for the comparable period in 1997.


        LIQUIDITY AND CAPITAL RESOURCES

        The Company used $1.7 million of cash in operating activities in the
six-months ended June 30, 1998, as compared to $650,000 in the comparable prior
period. Operating activities for both periods required cash primarily to support
increases in accounts receivable and inventory resulting from the growth in
product sales.

        Net cash used in investing activities was $11.6 million in the six-month
period ended June 30, 1998, as compared to $705,000 in the comparable prior
period. Cash used in investing activities during the six-month period ended June
30, 1998 included the funding of the purchase of Novagen Inc., and capital
expenditures related primarily to improvements to manufacturing and distribution
capabilities at various locations.

        In October 1996, the Company completed the initial public offering of
1,840,000 shares of Common Stock at $12.50 per share. In April 1997, the Company
completed a public offering of 1,150,000 shares of Common Stock (including
910,190 shares sold by a founding stockholder of the Company) at $13.50 per
share.

        The Company is a holding company, the principal assets of which are the
capital stock of its subsidiaries, and has no independent means of generating
revenues. As a holding company, the Company depends on dividends and other
permitted payments from its subsidiaries, including its international
subsidiaries, to meet its cash needs. The Company maintains cash balances at its
various subsidiaries based upon local results of operations. The amount of
foreign-sourced earnings to be repatriated to the United States is determined
based upon foreign entity capitalization, local cash needs, local and U.S. tax





                                       10
<PAGE>   11

implications and requirements for cash in the U.S. operations.

        At June 30, 1998, the Company had cash, cash-equivalents and short term
investments of $5.6 million and working capital of $29.2 million. At June 30,
1998, $5.0 million was available under a Credit Facility with a commercial bank
which expires in June 2000.

        The Company may be required to conduct business in the new European
currency (the "Euro) effective in January 1999. Management has established a
plan to convert necessary systems and marketing materials to the Euro. The
effect of the introduction of the Euro on the Company's business and results of
operations is uncertain.

        The Company believes that its existing capital resources will be
adequate to fund its operations. If, however, the Company were to undertake a
significant acquisition or if working capital or other capital requirements are
greater than currently anticipated, the Company could be required to seek
additional funds through sales of equity, debt or convertible securities or
increased credit facilities. There can be no assurance that additional financing
will be available or that, if available, will be on terms favorable to the
Company and its stockholders.


        IMPACT OF YEAR 2000

        During 1997, the Company developed a plan, and installed new operating
systems software and computer hardware, to address anticipated Year 2000 issues
in connection with its information systems and business relationships. It is
currently estimated that the net cost for review, analysis, modification and
testing of existing computer programs for both internal and external software
will be between $300,000 and $500,000. The Company has incurred a portion of
such expenses in the current and prior fiscal years and it is anticipated that a
substantial portion of the remaining estimated cost will be incurred during the
remainder of this year and next year. In accordance with generally accepted
accounting principles, these costs are expensed as incurred.


        FORWARD-LOOKING STATEMENTS

        This Quarterly Report on Form 10-Q contains forward-looking statements,
which involve risks and uncertainties. The Company's actual results in the
future could differ significantly from the results discussed in such
forward-looking statements. Factors that could cause or contribute to such a
difference include, but are not limited to, those set forth under the captions
Risk Factors and Management's Discussion and Analysis of Financial Condition and
Results of Operations.


        RISK FACTORS

        Dependence on Research and Development Budgets and Government Research
Funding. The Company's customers include research scientists at pharmaceutical
and biotechnology companies, academic institutions and government and private
research laboratories. Fluctuations in the research and development budgets of
these companies and institutions can have a significant effect on the demand for
the Company's products. Such budgets are based on a wide variety of factors
including the resources available to make such expenditures, the spending
priorities among various types of research and the policies regarding such
expenditures during recessionary periods. Any decrease in life sciences research
and development expenditures by such companies and institutions could have a
material adverse effect on the Company's business, financial condition and
results of operations.

        A significant portion of the Company's sales have been to research
scientists, universities, government research laboratories, private foundations
and other institutions whose funding is dependent on grants from government
agencies such as the U.S. National Institutes of Health ("NIH") and similar
domestic and international agencies. The funding associated with approved NIH
grants generally becomes available at particular times of the year, as
determined by the federal government, and may result in fluctuations in the





                                       11
<PAGE>   12

Company's operating results. Although research funding has increased during the
past several years, grants have, in the past, been frozen for extended periods
or have otherwise become unavailable to various institutions, sometimes without
advance notice. Furthermore, government proposals aiming to reduce or eliminate
budgetary deficits have in the past included reduced allocations to the NIH and
the other government agencies that fund research and development activities. If
government funding, especially NIH grants, were to become unavailable to
researchers for any extended period of time or if overall research funding were
to decrease, there could be a material adverse effect on the Company's business,
financial condition and results of operations.

        Risks Inherent in Growth, Expansion and Acquisition Strategy. The
Company has sought and will continue to seek growth in sales and profitability
primarily through the internal development and acquisition of new product lines,
additional customers and new businesses. A significant portion of the Company's
historical revenue growth is attributable to internal product development,
sourcing of third-party products and more recently from its acquisition of
Novagen, Inc. The ability of the Company to achieve its expansion objectives and
to manage its growth effectively depends upon a variety of factors, including
(i) the ability to internally develop products, (ii) the ability to identify and
license products sourced from third parties, (iii) the ability to successfully
position and market its products, (iv) the ability to identify and consummate
attractive acquisitions and (v) the ability to integrate new businesses,
facilities and personnel into existing operations. If the Company is unable to
manage growth effectively, there could be a material adverse effect on the
Company's business, financial condition and results of operations.

        The Company competes for acquisition and expansion opportunities with
other companies that have significantly greater financial and other resources
than those of the Company. There can be no assurance that suitable acquisition
or investment opportunities will be identified, consummated, or, if consummated,
integrated successfully and profitably into the Company's operations. Moreover,
there can be no assurance that the Company's historic rate of growth or
expansion will continue, or that further growth or expansion will result in
continued profitability. The Company successfully completed the purchase of
Novagen, Inc. in December 1997. Although management expects to be able to
integrate the business activities of Novagen into its existing marketing and
distribution facilities and to gain synergies and growth, there can be no
assurance that such integration will be successful or that sales and profits
will increase. If the Company is unable to integrate Novagen, there could be a
material adverse effect on the Company's business financial condition and
results of operations.

        Reliance on Niche Research Market Strategy. Key elements of the
Company's strategy include the targeting and penetration of emerging life
sciences niche research markets and the continued development of the niche
research markets currently served by the Company. If the Company is unable to
successfully target and penetrate these niche research markets or is unable to
continue developing the niche research markets currently served or if the
Company's new products are not accepted by research scientists, there could be a
material adverse effect on the Company's business, financial condition and
results of operations. In addition, the Company currently benefits from its
participation in emerging niche research markets which, as they expand, may
attract the attention of the Company's competitors. Further, as these niche
research markets mature, products that were once innovative, thus commanding
higher margins, may become commodities.

        Dependence on New Products; Rapid Technological Change. The life
sciences research products market is characterized by rapid technological change
and frequent product introductions. The Company's future success will depend, in
part, on its ability to develop and introduce, on a timely basis, products that
address the evolving needs of its customers. There can be no assurance that the
Company will not experience difficulties that could delay or prevent the
successful development, introduction and marketing of products. The Company has
experienced, and may in the future experience, delays in the development and
introduction of products, and there can be no assurance that the Company will
keep pace with the rapid rate of change in life sciences research, and will not
experience additional delays in the future. In addition, there can be no
assurance that new products will adequately meet the requirements of the
marketplace or achieve market acceptance. Factors affecting whether such
products will be accepted by the market include use of the product by research
scientists, citation of the product in published research, the timing of market
entry of the product relative to competitive products and general trends in life
sciences research. If the 





                                       12
<PAGE>   13

Company is unable, for technological or other reasons, to develop and introduce
products in a timely manner in response to changing market environments or
customer requirements, there could be a material adverse effect on the Company's
business, financial condition and results of operations.

        Dependence on Licensing as a Source of Products. Many of the Company's
products are manufactured or sold pursuant to license agreements under which the
Company pays royalties to the patent holder based upon a percentage of the
product's sales. There can be no assurance that the Company will be able to
continue to successfully identify new products developed by others, and if
identified, to negotiate license agreements on favorable terms. Additionally,
there can be no assurance that the Company will be able to renew any existing
license agreements upon their expiration.

        Highly Competitive Market. The market for the Company's products is
highly competitive, and the Company expects competition to increase.
Furthermore, although the life sciences research products market continues to
grow, its rate of growth in recent years has been declining and may continue to
decline. The Company competes with many other life sciences research products
suppliers, both larger and smaller than the Company. Some of the Company's
competitors, including two of its largest competitors, Sigma-Aldrich Corporation
and Roche Molecular Biochemicals, offer a broad range of equipment, laboratory
supplies and other products, including many of the research products offered by
the Company. To the extent that researchers exhibit loyalty to the supplier that
first supplies them with a particular research product, the Company's
competitors may have an advantage over the Company with respect to products
first developed by such competitors. In addition, many of the Company's
competitors have significantly greater research and development, marketing,
financial and other resources than the Company, and therefore represent and will
continue to represent significant competition in the Company's existing and
future markets. Because of their size and the breadth of their product
offerings, certain of these companies have been able to establish managed
accounts by which, through a combination of direct computer links and volume
discounts, they seek to gain a disproportionate share of orders for research
products from particular academic institutions or pharmaceutical or
biotechnology companies. Such managed accounts raise significant competitive
barriers for the Company. The Company currently benefits from its participation
in emerging niche research markets which, as they expand, may attract the
attention of the Company's competitors.

        Reliance on Catalogs, Distributors and Direct Marketing Efforts; Limited
Sales Force. The Company sells its products principally through catalogs
distributed to research scientists and laboratories, and uses only a very
limited number of salespeople in certain of its markets. There can be no
assurance that the Company would be able to successfully establish other methods
of marketing and sales of its products should it become necessary or desirable
in the future. Additionally, the Company's catalogs are generally reissued every
12 to 24 months and price adjustments between catalog publication dates have
historically been infrequent. A significant portion of the Company's
international sales are made through independent distributors over which the
Company has no control and who also represent products of other companies. The
loss of any of these distribution methods could have a material adverse effect
on the Company's business, financial condition and results of operations.

        Volatility of Bulk Sales Business. In addition to sales of its core
products in standard laboratory quantity sizes (generally ranging from 100
nanograms to 100 grams), the Company offers certain products in bulk quantities
(generally up to ten kilograms) at discounts from catalog prices. Bulk sales,
which represented 20.0% of net sales during the quarter ended June 30, 1998, are
generally characterized as relatively high dollar sales made to a limited number
of customers. Thus, the absence or presence of a bulk sale could have a material
impact on quarterly results. Furthermore, the Company's bulk sales business
fluctuates more and is less predictable than its core business, and the
uncertain timing and volatility of bulk sales has in the past and may continue
in the future to materially affect the Company's business, financial condition
and results of operations.

        Significant Fluctuations in Quarterly Earnings. The Company's quarterly
operating results may vary significantly from quarter to quarter as a result of
a number of factors including new editions of existing catalogs, introduction of
additional specialty catalogs and bulk sales of the Company's products. Other
factors which may affect quarterly operating results include the timing of the
U.S. Government approval of the NIH budget, lower European and academic sales
during the summer months and various holiday breaks





                                       13
<PAGE>   14

and fluctuations in weather. The Company's current and planned expense levels
are based in part upon its expectations as to future revenues. Consequently, if
revenues in a particular quarter do not meet expectations, the Company may not
be able to adequately adjust operating expenses to compensate for the shortfall.
Operating results may therefore vary significantly from quarter to quarter and
will not necessarily be indicative of results in subsequent periods.

        Uncertainty of Future Operating Results. Although the Company had net
income for 1995, 1996 and the first two quarters of 1998, the Company incurred a
net loss for the year ended December 31, 1997 due to a one time write-off of
in-process technology associated with the acquisition of Novagen, Inc. Future
operating results will depend on many factors, including demand for the
Company's products, the levels and timing of government and private sector
funding of life sciences research and development activities, the timing of the
introduction of products and catalogs by the Company or its competitors, and the
Company's ability to control costs. Furthermore, the Company's gross margins can
be significantly affected by the presence or absence of bulk sales during any
particular period and quarterly fluctuations in sales relative to operating
expenses. There can be no assurance that the Company will be able to grow in
future periods or remain profitable.

        Risks Relating to International Sales and Operations. Historically,
product sales to customers outside the United States have accounted for
approximately 50% of the Company's net sales, and the Company expects that
international sales will continue to account for a significant percentage of
revenues in the future. International sales and operations may be materially
adversely affected by trade restrictions, changes in tariffs and taxes, export
license requirements, difficulties in staffing and managing international
operations, difficulties in converting systems and marketing materials to the
Euro, market acceptance of the Euro, problems in establishing or managing 
distributor relationships and general economic conditions.

        A majority of the Company's sales are denominated in U.S. dollars, with
the balance denominated in foreign currencies. Additionally, the Company
publishes a number of its catalogs priced in foreign currencies and price
adjustments between catalog publication dates to reflect fluctuations in the
value of foreign currencies relative to the U.S. dollar have historically been
infrequent. Consequently, fluctuations in the value of foreign currencies
relative to the U.S. dollar, the introduction of the Euro in January of 1999,
and changes in general international economic conditions including market
acceptance of the Euro could have a material adverse effect on the Company's 
business, financial condition and results of operations.

        Risk of Patent Infringement. Because of the breadth of the Company's
product offerings and ambiguities in intellectual property law, the Company
periodically receives in the ordinary course of business notices of potential
infringement of patents held by others. Although the Company historically has
been able to satisfactorily resolve such claims and believes that any
outstanding claims will be satisfactorily resolved, there can be no assurance
that the Company may not be forced to discontinue the sale of one or more of its
products, some or all of which could be material. Additionally, the Company
believes that the molecular biology area, in which Novagen, its newly acquired
brand, competes, has a higher incidence of involvement in patent disputes. As
the Company develops product offerings focused on certain niche research
markets, intellectual property rights of the Company or others related to such
markets may become increasingly important, and the Company's failure to obtain
and retain such rights may have a material adverse effect on the Company's
business, financial condition and results of operations.

        Dependence on Key Personnel. The Company's future success depends in
significant part on the continued service of, and on the Company's continuing
ability to attract and retain, highly qualified technical, managerial and sales
personnel. Competition for such personnel is intense in the Company's industry
and geographic locations, and there can be no assurance that the Company will be
able to retain or attract such employees in the future. The loss of key
personnel or the inability to hire or retain qualified personnel could have a
material adverse effect on the Company's business, financial condition and
results of operations. The Company has entered into employment agreements with
Stelios B. Papadopoulos, its Chairman, Chief Executive Officer and President,
and Ben Matzilevich, its Vice President, Market Development -- Niche
Applications.

        Risk Relating to the Influence of the Internet on Marketing and
Catalogs. The Internet has begun to





                                       14
<PAGE>   15

change marketing patterns in a wide variety of industries. The high degree of
personal computer usage within scientific research organizations may lead to
entirely new methods of marketing and sales of research products. While the
Company has established home pages on the Internet for the Calbiochem,
Novabiochem, Oncogene Research Products and Novagen brands, the Company may not
be able to keep pace with the rate of change in its markets brought about by the
Internet and may invest in catalogs or Internet-based projects which future
changes may render obsolete.

        Compliance with Government and Environmental Regulations. The Company is
subject to various forms of government regulations, including environmental and
safety laws and regulations and laws governing use and storage of hazardous
materials. The Company has in the past been notified of minor violations of
government and environmental regulations. The Company has promptly corrected
such violations without any material impact on the Company's operations. Any
future violation of, and the cost of compliance with, these laws and regulations
could have a material adverse effect on the Company's business, financial
condition and results of operations.

        Because of the nature of its operations and the use of hazardous
substances in its ongoing manufacturing and research and development activities,
the Company is subject to stringent federal, state and local laws, rules,
regulations and policies governing the use, generation, manufacturing, storage,
air emission, effluent discharge, handling and disposal of certain materials and
wastes. Prior to the Company's inception, its U.S. subsidiary, at the time it
was owned by its former owners, was involved in two separate incidents related
to the release of hazardous materials into the environment at a leased facility
which is no longer occupied by the Company. The Company believes from a review
of correspondence from various regulatory agencies that these incidents were
investigated and remediated by the U.S. subsidiary's former owners. Although the
Company believes it is in material compliance with all applicable government and
environmental laws, rules, regulations, and policies, there can be no assurance
that the Company's business, financial condition and results of operations will
not be materially adversely affected by current or future environmental laws,
rules, regulations and policies or by liability arising out of any past or
future releases or discharges of materials that could be hazardous.

        Product Liability Risk; Limited Insurance Coverage. Although the Company
does not sell products intended for use in humans, or, with the exception of its
Clinalfa products, sell products intended for use in human clinical trials, the
Company's business could expose it to potential liability risks. The Company
currently has only limited product liability insurance, and there can be no
assurance that it will be able to maintain such insurance or obtain additional
insurance on acceptable terms or that insurance will provide adequate coverage
against potential liabilities. A successful product liability claim or a series
of claims brought against the Company in excess of its insurance coverage limits
could have a material adverse effect on the Company's business, financial
condition and results of operations.

        Holding Company Structure. The Company is a holding company, the
principal assets of which are certain cash balances and the capital stock of its
subsidiaries, and has no independent means of generating operating revenues. As
a holding company, the Company depends primarily on dividends and other
permitted payments from its subsidiaries, including its international
subsidiaries, to meet its cash needs. The Company maintains cash balances at its
various subsidiaries adequate to support local operations. The amount of
foreign-sourced earnings to be repatriated to the United States is determined
based upon foreign entity capitalization, local cash needs, local and U.S. tax
implications and requirements for cash in the U.S. operations.

        Substantial Influence of Principal Stockholder. The Company's principal
stockholder, Warburg, Pincus Investors, L.P. ("Warburg") beneficially owns
approximately 40% of the Company's Common Stock, par value $.01 per share (the
"Common Stock"). Because of such ownership, Warburg has substantial influence
over the election of all members of the Board of Directors and corporate actions
requiring stockholder approval. Additionally, pursuant to an agreement with the
Company, Warburg has certain rights to nominate directors as long as it
continues to own specified percentages of the outstanding shares of Common
Stock.

        Anti-Takeover Provisions. Under the Company's Amended and Restated
Certificate of Incorporation





                                       15
<PAGE>   16

(the "Certificate of Incorporation"), the Company's Board of Directors has the
authority to issue up to 5,000,000 shares of Preferred Stock and to determine
the price, rights, preferences and privileges of those shares without any
further vote or action by the stockholders. The rights of the holders of Common
Stock will be subject to, and may be adversely affected by, the rights of the
holders of any Preferred Stock that may be issued in the future. The issuance of
Preferred Stock, while providing desirable flexibility in connection with
possible acquisitions and other corporate purposes, could have the effect of
making it more difficult for a third party to acquire a majority of the
outstanding voting stock of the Company. The Company has no present plans to
issue shares of Preferred Stock. The Company is also subject to the provisions
of Section 203 of the Delaware General Corporation Law, an anti-takeover law.
Additionally, the Company has entered into severance arrangements with each of
its executive officers which provide, among other things, for severance payments
if, within 90 days of a "change in control" of the Company (as defined in the
applicable agreements), the executive's employment is terminated other than for
cause or the executive resigns. Such arrangements could have an anti-takeover
effect.


Item 3. Quantitative and Qualitative Disclosures About Market Risk

        Not required.































                                       16

<PAGE>   17

                           PART II - OTHER INFORMATION

Item 4. Submission of Matters to a Vote of Security Holders

        The Company held its Annual Meeting of Stockholders (the "Annual
        Meeting") on April 21, 1998. Of the 5,653,785 shares of Common Stock
        which could be voted at the Annual Meeting, 5,184,886 shares of Common
        Stock, representing 91.7%, were represented at the Annual Meeting in
        person or by proxy, which constituted a quorum. Voting results were as
        follows:

        (a) Election of the following persons to the Company's Board of
        Directors, to hold office until the next annual meeting of stockholders
        and until their successors have been duly elected and qualified:

<TABLE>
<CAPTION>
                                                FOR                WITHHELD
                                             ---------             --------
        <S>                                  <C>                     <C>  
        Joseph P. Landy                      5,182,526               2,360
        Dr. Richard A. Lerner                5,148,526              36,360
        S. Joshua Lewis                      5,182,526               2,360
        Robert E. McGill III                 5,182,526               2,360
        Stelios B. Papadopoulos              5,182,526               2,360
</TABLE>

        (b) Amendment of the Company's Amended and Restated 1992 Stock Option
        Plan to increase the number of shares of Common Stock reserved for
        issuance thereunder by 350,000 shares from 1,085,000 shares to 1,435,000
        shares:

                         FOR                   AGAINST              ABSTAIN
                         ---                   -------              -------
                      4,347,268                508,250                860

        (c)    Ratification of the appointment by the Board of Directors of
               Ernst & Young LLP as the independent public
        auditors of the Company for the fiscal year ending December 31, 1998:

                         FOR                   AGAINST              ABSTAIN
                         ---                   -------              -------
                      5,180,626                 1,600                2,660

Item 6. Exhibits and Reports on Form 8-K.

        (a) Exhibits:

           3(a)              Amended and Restated Certificate of Incorporation*

           3(b)              Amended and Restated By-Laws*

           10(n)(xxiv)       Amendment to Loan Agreement, dated June 23, 1998,
                             by and between Silicon Valley Bank and Calbiochem-
                             Novabiochem Corporation.

           11                Statement re computation of per share earnings

           27                Financial Data Schedule

        (b) Reports on Form 8-K:

        No reports on Form 8-K were filed by the Registrant during the three
months ended June 30, 1997.

- ---------------------
*   Incorporated by reference from the Registrant's Form 10-Q for the quarterly
    period ended September 30, 1996 (File No. 000-21281)






                                       17
<PAGE>   18

                                   SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                        CN BIOSCIENCES, INC.



August 12, 1998                         /s/ Stelios B. Papadopoulos
                                        ----------------------------------------
                                        Stelios B. Papadopoulos
                                        Chief Executive Officer, Chairman
                                        and President
                                        (duly authorized officer)


August 12, 1998                         /s/ James G. Stewart
                                        ----------------------------------------
                                        James G. Stewart
                                        Vice President, Chief Financial Officer
                                        and Secretary
                                        (principal financial officer)













                                       18
<PAGE>   19


                                INDEX OF EXHIBITS



<TABLE>
<CAPTION>
Exhibit Number      Description
- --------------      -----------
<S>                 <C>
3(a)                Amended and Restated Certificate of Incorporation*

3(b)                Amended and Restated By-Laws*

10(n)(xxiv)         Amendment to Loan Agreement, dated June 23, 1998, by and 
                    between Silicon Valley Bank and Calbiochem-Novabiochem 
                    Corporation.

11                  Statement re computation of per share earnings

27                  Financial Data Schedule
</TABLE>



- ---------------------
*   Incorporated by reference from the Registrant's Form 10-Q for the quarterly
    period ended September 30, 1996 (File No. 000-21281)











                                       19

<PAGE>   1
                                                             EXHIBIT 10(n)(xxiv)
                                                                                


SILICON VALLEY BANK



                           AMENDMENT TO LOAN AGREEMENT



BORROWER:             CALBIOCHEM-NOVABIOCHEM CORPORATION

ADDRESS:              10394 PACIFIC CENTER COURT
                      SAN DIEGO, CALIFORNIA  92121

DATE:                 JUNE 23, 1998


        THIS AMENDMENT TO LOAN AGREEMENT is entered into between SILICON VALLEY
BANK ("Silicon") and the borrower named above (the "Borrower").

        The Parties agree to amend, effective as of the date hereof, the Loan
and Security Agreement between them dated July 28, 1995, as amended by that
Amendment to Loan Agreement dated November 22, 1995, effective as of September
30, 1995, as amended by that Amendment to Loan Agreement dated January 24, 1996,
as amended by that Amendment to Loan Agreement dated May 27, 1997, as amended by
that Amendment to Loan Agreement dated June 27, 1997, as amended by that
Amendment to Loan Agreement dated December 22, 1997 and as amended by that
Amendment to Loan Agreement dated April 10, 1998 (as so amended and as otherwise
amended from time to time, the "Loan Agreement") as follows: (Capitalized terms
used but not defined in this Amendment, shall have the meanings set forth in the
Loan Agreement.)

        1. EXTENDED MATURITY DATE. The Maturity Date as set forth in the section
of the Schedule to the Loan Agreement entitled "Maturity Date (Section 5.1), is
hereby amended to be "July 1, 2000."

        2. MODIFICATION TO FINANCIAL COVENANT. The Tangible Net Worth financial
covenant set forth in the section of the Schedule to the Loan Agreement entitled
"Financial Covenants (Section 4.1)" is hereby amended to read as follows:

        "TANGIBLE NET WORTH:   Parent shall maintain a tangible net worth of not
                               less than $31,000,000."

        3. ADDITIONAL PERMITTED INDEBTEDNESS. Without Silicon's prior written
consent, notwithstanding any term or provision of the Loan Agreement to the
contrary, Borrower may incur additional indebtedness in the aggregate amount of
$1,000,000 outstanding at any one time, provided that, after giving effect
thereto, no Event of Default has occurred and no event has occurred which, with
notice or passage of time or both, would constitute an Event of Default:.

        4. FEE. Borrower shall pay to Silicon a fee in the amount of $12,500,
which shall be in addition to interest and to all other amounts payable
hereunder, and which shall not be refundable.

        5. REPRESENTATIONS TRUE. Borrower represents and warrants to Silicon
that all representations and warranties set forth in the Loan Agreement, as
amended hereby, are true and correct.





                                      -1-

<PAGE>   2

        6. GENERAL PROVISIONS. This Amendment, the Loan Agreement, any prior
written amendments to the Loan Agreement signed by Silicon and the Borrower, and
the other written documents and agreements between Silicon and the Borrower set
forth in full all of the representations and agreements of the parties with
respect to the subject matter hereof and supersede all prior discussions,
representations, agreements and understandings between the parties with respect
to the subject hereof. Except as herein expressly amended, all of the terms and
provisions of the Loan Agreement, and all other documents and agreements between
Silicon and the Borrower shall continue in full force and effect and the same
are hereby ratified and confirmed.

CALBIOCHEM-NOVABIOCHEM CORPORATION         SILICON VALLEY BANK



                                           By /s/ SUSAN BATCHEN
                                              ---------------------------------
                                           Title  Vice President
                                                 -------------------------------


By  /s/ JAMES G. STEWART
   ---------------------------------
   President


By  /s/ ARTHUR E. ROKE
   ---------------------------------
   Secretary



















                                      -2-

<PAGE>   3

                                                                        
                                                

                                     CONSENT


        The undersigned guarantors acknowledge that their consent to the
foregoing Amendment is not required, but the undersigned nevertheless do hereby
consent to the foregoing Amendment and to the documents and agreements referred
to therein and to all future modifications and amendments thereto, and to any
and all other present and future documents and agreements between or among the
foregoing parties. Nothing herein shall in any way limit any of the terms or
provisions of the Guaranties executed by the undersigned in favor of Silicon,
all of which are hereby ratified and affirmed and shall continue in full force
and effect.



CN BIOSCIENCES, INC.                       CALBIOCHEM-NOVABIOCHEM AG



By: /s/ JAMES STEWART                      By:  /s/ STELIOS B. PAPADOPOULOS
   ---------------------------------           ---------------------------------

Title: V.P.                                Title:  Director
      ------------------------------              ------------------------------























                                      -3-


<PAGE>   1

                                                                    Exhibit 11.1



                              CN BIOSCIENCES, INC.

                        COMPUTATION OF EARNINGS PER SHARE
                  (AMOUNTS IN THOUSANDS, EXCEPT PER SHARE DATA)


<TABLE>
<CAPTION>
                                                    THREE MONTHS ENDED     SIX MONTHS ENDED
                                                          JUNE 30               JUNE 30
                                                    ------------------     ----------------
                                                      1998       1997       1998       1997
                                                     -----      -----      -----      -----
<S>                                                  <C>        <C>        <C>        <C>  
Net income                                           1,391      1,062      2,538      1,872

Average common shares outstanding                    5,671      5,426      5,662      5,294

Net effect of dilutive common share equivalents
based on the treasury stock method                     215        300        212        332

Adjustments to reflect requirements of the
Securities and Exchange Commission (Effect
of SAB 83)                                              --         --         --         --
                                                     -----      -----      -----      -----

Adjusted shares outstanding                          5,886      5,726      5,874      5,626
                                                     -----      -----      -----      -----

Historical net income per share reflecting
requirements of the SEC                              $0.24      $0.19      $0.43      $0.33
                                                     -----      -----      -----      -----
Effect of assumed conversion of preferred
shares from date of issuance                            --         --         --         --
                                                     -----      -----      -----      -----
Adjusted shares outstanding                          5,886      5,726      5,874      5,626
                                                     -----      -----      -----      -----
Pro Forma net income per share                       $0.24      $0.19      $0.43      $0.33
                                                     =====      =====      =====      =====
</TABLE>





<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
REGISTRANT'S CONDENSED CONSOLIDATED FINANCIAL STATEMENTS AS OF AND FOR THE SIX
MONTHS ENDED JUNE 30, 1998 AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH
INTERIM CONSOLIDATED FINANCIAL STATEMENTS.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-START>                             JAN-01-1998
<PERIOD-END>                               JUN-30-1998
<CASH>                                           5,571
<SECURITIES>                                         0
<RECEIVABLES>                                    8,039
<ALLOWANCES>                                         0
<INVENTORY>                                     19,800
<CURRENT-ASSETS>                                36,500
<PP&E>                                           4,786
<DEPRECIATION>                                       0
<TOTAL-ASSETS>                                  52,862
<CURRENT-LIABILITIES>                            7,323
<BONDS>                                              0
                                0
                                          0
<COMMON>                                            58
<OTHER-SE>                                      43,275
<TOTAL-LIABILITY-AND-EQUITY>                    52,862
<SALES>                                         25,546
<TOTAL-REVENUES>                                25,546
<CGS>                                           11,497
<TOTAL-COSTS>                                   10,119
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                                  4,008
<INCOME-TAX>                                     1,470
<INCOME-CONTINUING>                              2,538
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     2,538
<EPS-PRIMARY>                                     0.43
<EPS-DILUTED>                                     0.43
        

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