CN BIOSCIENCES INC
SC 13G/A, 1998-03-03
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13G


                                 (Rule 13d-102)


             INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2


                   Under the Securities Exchange Act of 1934
                          (Amendment No.____________)*


               CN Biosciences Inc.
             -----------------------------------------------------
                                (Name of Issuer)

              Common-stock
             -----------------------------------------------------
                         (Title of Class of Securities)

               125946103
             -----------------------------------------------------
                                 (CUSIP Number)



Check the following box if a fee is  being paid with this statement [ ].


- ----------
*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

<PAGE>

CUSIP No. 125946103_____                       13G         Page _2_ of _4_ Pages



- --------------------------------------------------------------------------------
   1.  NAME OF REPORTING PERSON(S)
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON(S)

 
 
Standish,Ayer & Wood, Inc. 04- 1863660
- --------------------------------------------------------------------------------
   2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [x  ]


- --------------------------------------------------------------------------------
   3.  SEC USE ONLY




- --------------------------------------------------------------------------------
   4.  CITIZENSHIP OR PLACE OF ORGANIZATION



Massachusetts
- --------------------------------------------------------------------------------
   NUMBER OF      5.   SOLE VOTING POWER
     SHARES            318,900
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      6.   SHARED VOTING POWER
      EACH               0
   REPORTING      --------------------------------------------------------------
     PERSON       7.   SOLE DISPOSITIVE POWER
      WITH               318,900
                  --------------------------------------------------------------
                  8.   SHARED DISPOSITIVE POWER
                        0

- --------------------------------------------------------------------------------
   9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


              318,900
- --------------------------------------------------------------------------------
  10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*



- --------------------------------------------------------------------------------
  11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        5.64%
- --------------------------------------------------------------------------------
  12.  TYPE OF REPORTING PERSON*



           IA
- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
 
                                       13G                 Page _3 of 4__ Pages





Item 1.     (a)   Name of Issuer:
                     CN Biosciences Inc.
                  --------------------------------------------------------------
            (b)   Address of Issuer's Principal Executive Offices:
                    10394 Pacific Center Court, San Diego, CA. 92121
                  --------------------------------------------------------------
Item 2.     (a)   Name of Person Filing:
                      Standish, Ayer & Wood, Inc.
                -------------------------------------------------- ------------
            (b)   Address of Principal Business Office, or if None, Residence:
                    One Financial Center, Boston, MA. 02111
                 --------------------------------------------------------------
            (c)   Citizenship:
                                    U.S. (a Massachusetts corporation)
                               -------------------------------------------------
            (d)   Title of Class of Securities:
                    Common Stock
                  --------------------------------------------------------------
            (e)   CUSIP Number:
                                   125946103
                               -------------------------------------------------
Item 3.     If this statement  is filed  pursuant to Rules  13d-1(b), or
            13d-2(b), check whether the person filing is a:

            (a)   [ ]   Broker or Dealer  registered under Section  15 of  the
                        Act,

            (b)   [ ]   Bank as defined in Section 3(a)(6) of the Act,

            (c)   [ ]   Insurance Company  as defined  in Section  3(a)(19) of
                        the Act,

            (d)   [ ]   Investment Company registered under  Section 8 of  the
                        Investment Company Act,

            (e)   [ x]   Investment Adviser registered under Section 203 of the
                        Investment Advisers Act of 1940,

            (f)   [ ]   Employee Benefit Plan,  Pension Fund which is  subject
                        to the  provisions of  the Employee Retirement  Income
                        Security Act of  1974 or Endowment  Fund; see  Section
                        240.13d-1(b)(ii)(F); see Item 7,

            (g)   [ ]   Parent  Holding  Company, in  accordance  with Section
                        240.13d-1(b)(1)(ii)(G); see Item 7,

            (h)   [ ]   Group, in accordance with Section
                        240.13d-1(b)(1)(ii)(H).


<PAGE>
 
                                      13-G                   Page __ of __ Pages



Item 4.     Ownership.


            If more than five percent of the class is owned, indicate:

            (a) Amount beneficially owned: See page 2, No. 9
                                          -------------------------------------,

            (b) Percent of class:   See page 2, No. 11
                                 ----------------------------------------------,

            (c) Number of shares as to which such person has:

                  (i) Sole power to vote or to direct the vote See page 2, no.5
                                                              -----------------,

                  (ii) Shared power to vote or to direct the vote none
                                                                 --------------,

                  (iii) Sole power to dispose or to direct the disposition of
                           see page 2, no. 7
                        -------------------------------------------------------,


                  (iv) Shared power to dispose or to direct the disposition of
                           none
                        --------------------------------------------------, and


            (d) Shares which there is a right to acquire:
                                                         ----------------------.



Item 5.     Ownership of Five Percent or Less of a Class.
              If this statement is being filed to report the fact that as of 
             the date hereof the reporting person has ceased to be the 
beneficial owner of more than 5% of the class of securities, check the following

Item 6.     Ownership of More Than Five Percent on Behalf of Another Person.
            All securities reported upon in this schedule are owned by advisory
            clients of Standish,Ayer & Wood, Inc., no one of which to the 
            knowledge of Standish, Ayer & Wood, Inc. owns more than 5% of the 
            class.


Item 7.     Identification and Classification of the Subsidiary which Acquired
            the Security Being Reported on By the Parent Holding Company.
            Not Applicable

Item 8.     Identification and Classification of Members of the Group.
            Not Applicable

Item 9.     Notice of Dissolution of Group.
            Not Applicable
 
Item 10.    Certification.

            By  signing  below  -I/we-  certify  that,  to the  best  of  my/our
            knowledge and belief, the securities referred to above were acquired
            in the  ordinary  course of business  and were not  acquired for the
            purpose of and do not have the effect of changing or influencing the
            control of the issuer of such  securities  and were not  acquired in
            connection with or as a participant in any  transaction  having such
            purpose or effect.


<PAGE>


                                  Signature.


            After  reasonable  inquiry  and to the  best  of my  knowledge  and
            belief,  -I/we-  certify  that the  information  set  forth in this
            statement is true, complete and correct.


Date:

February 5,1998
- ----------------------------------
                      (Signature)*

Beverly Banfield, Associate Director
- ----------------------------------
                      (Name/Title)


* Attention. Intentional misstatements or omissions of fact constitute federal
  criminal violations (see 18 U.S.C. 1001).




(022597DTI)


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