NYMOX PHARMACEUTICAL CORP
F-1, 2000-02-29
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM F-1

                             REGISTRATION STATEMENT

                                      UNDER

                           THE SECURITIES ACT OF 1933

                        NYMOX PHARMACEUTICAL CORPORATION

             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

<TABLE>
<S>                                                   <C>                       <C>
         QUEBEC, CANADA                               8071                      NOT APPLICABLE
(Province or other jurisdiction of         (Primary Standard Industrial        (I.R.S. Employer
  incorporation or organization)            Classification Code Number)       Identification No.)
</TABLE>

                         9900 Cavendish Blvd., Suite 306
                         St. Laurent, QC, Canada H4M 2V2
                                 (800) 936-9669

   (Address and telephone number of Registrant's principal executive offices)

                                Nymox Corporation
                         5516 Nicholson Lane, Suite 100A
                              Kensington, MD 20895
                                  (800) 93NYMOX

            (Name, address and telephone number of agent for service)

                                   Copies to:

<TABLE>
               <S>                                       <C>
                      Marc J. Marotta                              Jack Gemmell
                      Foley & Lardner                   Nymox Pharmaceutical Corporation
                  777 East Wisconsin Avenue              9900 Cavendish Blvd. Suite 306
                Milwaukee, Wisconsin 53202-5367          St.-Laurent, QC, Canada H4M 2V2
                        (414) 271-2400                           (514) 332-3222
</TABLE>

   Approximate date of commencement of proposed sale to the public: As soon as
        practicable after this Registration Statement becomes effective.

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, check the following box. [X]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

If this Form is a post effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

<PAGE>   2
                         CALCULATION OF REGISTRATION FEE

All financial information in this prospectus is in United States dollars unless
otherwise noted.

<TABLE>
<CAPTION>
- ----------------------- ---------------------- --------------------- ----------------------- -----------------
Title of each class         Amount to be         Proposed maximum       Proposed maximum        Amount of
of securities to be          registered        aggregate price per     aggregate offering    registration fee
registered                                             unit                  price
- ----------------------- ---------------------- --------------------- ----------------------- -----------------
<S>                         <C>                        <C>              <C>                      <C>
                              Up to
Common shares               4,800,000 (1)              (2)              $12,000,000 (3)           $3,168
- ----------------------- ---------------------- --------------------- ----------------------- -----------------
                               Up to
Common shares(4)              200,000                 $4.52                $904,000              $238.66
- ----------------------- ---------------------- --------------------- ----------------------- -----------------
                              Up to
Total                       5,000,000                                   $12,904,000            $3,406.66
- ----------------------- ---------------------- --------------------- ----------------------- -----------------
</TABLE>

(1)  Estimated solely for the purpose of calculating the registration fee
     pursuant to Rule 457 under the Securities Act of 1933.

(2)  The price per common share will vary based on the average daily price of
     Nymox's shares during the draw down periods provided for in the common
     stock purchase agreement described in this registration statement. The
     purchase price will be equal to 94% of the average daily price for each
     trading day within such draw down pricing periods. The agreement allows for
     24 draws over a period of 30 months for amounts up to $750,000 per draw.

(3)  $12,000,000 represents the maximum total purchase price that Jaspas is
     obliged to pay Nymox under the common stock purchase agreement; the maximum
     net proceeds Nymox can receive is $12,000,000 less a 3% placement fee
     payable to its placement agents, Ladenburg Thalmann & Co. Inc., or
     $11,640,000.

(4)  These common shares represent the shares issuable on the exercise of a
     stock purchase warrant issued by Nymox to Jaspas on November 12, 1999 under
     the common stock purchase agreement. Under the warrant, Jaspas may purchase
     up to 100,000 shares any time between November 30, 1999 and November 30,
     2004. Jaspas may purchase the remaining 100,000 shares if and only if Nymox
     does not draw down $7,000,000 within eighteen months of this registration
     statement becoming effective.


                               __________________


     The Registrant hereby amends this registration statement on such date or
     dates as may be necessary to delay its effective date until the Registrant
     shall file a further amendment which specifically states that this
     registration statement shall thereafter become effective in accordance with
     Section 8(a) of the Securities Act of 1933 or until the registration
     statement shall become effective on such date as the Securities and
     Exchange Commission ("Commission"), acting pursuant to Section 8(a), may
     determine.





<PAGE>   3

The information in this prospectus is incomplete and may be changed. The selling
security holders may not sell these securities until the registration statement
filed with the Securities and Exchange Commission is effective. This prospectus
is not an offer to sell these securities and is not soliciting an offer to buy
these securities in any state where the offer or sale is not permitted.

                                                          PRELIMINARY PROSPECTUS

                                  [NYMOX LOGO]

                        NYMOX PHARMACEUTICAL CORPORATION

                        5,000,000 SHARES OF COMMON STOCK

<TABLE>
<S>                                                        <C>

                                                           Jaspas Investments Limited may use this
                                                           prospectus to resell up to 5,000,000 shares of
NYMOX PHARMACEUTICAL CORPORATION                           common stock of Nymox Pharmaceutical
                                                           Corporation.


9900 Cavendish Blvd.                                       Nymox will not receive any of the proceeds from
Suite 306                                                  the sale of the shares by Jaspas. However, we will
St.-Laurent, Quebec, Canada                                receive the sale price of any common stock that we
H4M 2V2                                                    sell to Jaspas under the common stock purchase
(800) 936-9669                                             agreement or under the stock purchase warrant
                                                           described in this prospectus. Nymox will pay the
                                                           costs of registering the shares under this
                                                           prospectus, including legal fees.


                                                           Jaspas may offer shares of common stock of
Nymox's common stock is listed on the Nasdaq               Nymox to purchasers in transactions on the Nasdaq
SmallCap Market under the symbol "NYMX". The               SmallCap Market, in negotiated transactions, or
last reported sales price for Nymox's common               otherwise, or by a combination of these methods.
stock on the Nasdaq SmallCap Market on ______              Jaspas may sell the shares through broker-dealers
_____ was $ ________  per share.                           who may receive compensation from Jaspas in the
                                                           form of discounts or commissions. Jaspas does not
                                                           intend to effect resales in Canada or through any
                                                           Canadian exchange. Jaspas is an "underwriter"
                                                           within the meaning of the Securities Act of 1933 in
                                                           connection with such sales.
</TABLE>

INVESTING IN THE COMMON STOCK OF NYMOX INVOLVES A HIGH DEGREE OF RISK. SEE "RISK
FACTORS" BEGINNING ON PAGE 8.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES, OR DETERMINED IF
THIS PROSPECTUS IS TRUTHFUL OR ACCURATE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.
                   _________________________________________

           The date of this prospectus is ___________________ , 2000.

                   _________________________________________

                                       1



<PAGE>   4

                               NOTE ABOUT CURRENCY

This prospectus provides financial information in United States dollars unless
otherwise noted. The following table sets forth the high and low noon exchange
rates, the average rates (average of the exchange rates on the last day of each
month during the period) and the end of period rates for one United States
dollar, expressed in Canadian dollars, from Dec.31, 1995 to Dec.31, 1999 as
reported by the Federal Reserve Bank of New York. The noon exchange rate was
$ ________ Canadian dollars to the United States dollar on _________________,
2000.

RECENT HISTORY OF THE EXCHANGE RATE FOR CANADIAN DOLLARS TO UNITED STATES
DOLLARS.

<TABLE>
<CAPTION>
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
PERIOD ENDED        Dec.31/95         Dec.31/96         Dec.31/97         Dec.31/98         Dec.31/99
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
<S>                 <C>               <C>               <C>               <C>               <C>
Period end          $1.3655           $1.3697           $1.4288           $1.5375           $1.4440
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
Average             $1.3725           $1.3638           $1.3849           $1.4836           $1.4858
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
High                $1.4238           $1.3822           $1.4398           $1.5770           $1.5302
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
Low                 $1.3285           $1.3310           $1.3357           $1.4075           $1.4440
- ------------------- ----------------- ----------------- ----------------- ----------------- -----------------
</TABLE>

                                       2


<PAGE>   5
In this prospectus, the term "Nymox" refers to both Nymox Pharmaceutical
Corporation and its wholly-owned subsidiary, Nymox Corporation and, where
applicable, a predecessor private corporation, DMS Pharmaceuticals Inc.

                                   THE COMPANY

Nymox is a development stage biopharmaceutical company based in Kensington,
Maryland and Saint Laurent, Quebec, Canada.

We specialize in the research and development of therapeutics and diagnostics
for the aging population with an emphasis on Alzheimer's disease. Alzheimer's
disease is a progressive, terminal brain disease of the elderly marked by an
irreversible decline in mental abilities, including memory and comprehension,
and often accompanied by changes in behavior and personality. It currently
afflicts an estimated four million people in the United States and at least 20
million people worldwide. As the baby-boomer generation continues to age, these
figures are expected to rise sharply.

AD7C(TM) Test

We market a proprietary diagnostic test for Alzheimer's disease, known as the
AD7C(TM) Test, in the United States through our reference laboratory in
Kensington, Maryland. The test is available both as a urine test, where the
patient provides a first-morning urine sample for testing, and as a
cerebrospinal fluid test, where a doctor draws a small sample of spinal fluid
from the patient. The test measures the level of a brain protein that is
elevated early in both the urine and the cerebrospinal fluid of patients with
Alzheimer's disease. The test is accurate and specific to Alzheimer's disease
and helps physicians make an early diagnosis of the disease.

The early diagnosis of Alzheimer's disease is important to physicians, patients
and their families and enables them to make informed and early social, legal and
medical decisions about treatment and care. Early diagnosis of Alzheimer's
disease has become increasingly important with new improvements in drug
treatment and care. Even a modest delay in institutionalization can mean
substantial social and financial savings. Conversely, any testing procedure that
could rule out Alzheimer's disease would eliminate the tremendous uncertainty
and anxiety patients and their families otherwise face and would allow
physicians to focus on the other, often reversible, causes of cognitive changes.
Early diagnosis as facilitated by the AD7C(TM) test represents a potentially
large cost-savings in the form of a reduced number of office visits, lab tests,
scans and other procedures required by the traditional methods of diagnosis.

Products in Development

We are in the process of developing the following products:


                                       3




<PAGE>   6

7C GOLD(TM) AN IMPROVED VERSION OF OUR AD7C(TM) TEST

     We are developing an improved version of our AD7C(TM) Test that aids
     physicians in the diagnosis of Alzheimer's disease. This version is known
     as the 7C Gold test. At present, the AD7C(TM) Test is conducted in a
     specialized reference laboratory to which physicians send patient samples
     to be tested. The 7C Gold test is designed as a kit which permits the
     testing of patient samples either in a general purpose medical laboratory
     or in a physician's office. Subject to further laboratory and clinical
     validation and to any necessary regulatory approvals, we intend to sell the
     7C Gold test worldwide within the next 12 to 18 months.

OTHER BIOCHEMICAL INDICATORS OF ALZHEIMER'S DISEASE

     We also hold exclusive patent rights to several other biochemical
     indicators for Alzheimer's disease, such as a protein referred to as 35i9
     derived from the brain. We intend to use our extensive scientific, medical
     and commercial experience and know-how in the field of Alzheimer's disease
     in order to develop new diagnostic tests and treatments for the disease
     from these and other indicators.

DRUGS TARGETING SPHERONS

     We are a world leader in research and development into drugs for the
     treatment of Alzheimer's disease that target spherons. Spherons are
     microscopic, compact balls of protein found in the brains of all humans
     from age 1. Nymox researchers believe that spherons are the cause of
     Alzheimer's disease and that stopping or inhibiting the transformation of
     spherons into senile plaques, the characteristic injury found in the brains
     of Alzheimer's disease patients, will stop or slow the progress of this
     illness. We now have several drug candidates, which have shown promise in
     animal and other preclinical studies and for which we plan to seek
     regulatory approval to begin clinical studies for humans. You should be
     aware that there is no consensus among researchers about the causes or
     possible treatments of Alzheimer's disease and that other researchers do
     not share this belief that Spherons are the cause of Alzheimer's disease or
     are a target for the development of treatments for the disease. Nymox has
     patents covering both methods for using spherons as targets for developing
     drugs and for the actual drug candidates discovered.

NEW ANTIBACTERIAL AGENTS AGAINST INFECTIONS AND FOOD CONTAMINATION

     Outside of the area of the treatment and diagnosis of Alzheimer's disease,
     we are developing a new class of antibacterial agents for the treatment of
     urinary tract and other bacterial infections in humans which have proved
     highly resistant to conventional antibiotic treatments and for the
     treatment of E. coli 0157:H7 bacterial contamination in hamburger meat and
     other food and drink products.

Nymox Pharmaceutical Corporation was incorporated in Canada in May, 1995 to
acquire all of the common shares of DMS Pharmaceutical Inc., a private company
which had been carrying on research and development since 1989 on diagnostics
and drugs for brain disorders and diseases of the aged with an emphasis on
Alzheimer's disease.


                                       4




<PAGE>   7

Nymox's principal executive offices are located at:

     Nymox Pharmaceutical Corporation

          9900 Cavendish Boulevard, Suite 306
          St.-Laurent, Quebec, Canada
          H4M 2V2
          Phone: (800) 936-9669
          Fax: (514) 332-2227

     Nymox Corporation

          5516 Nicholson Lane Suite 100A
          Kensington, Maryland 20895
          Phone: (301) 984-0500
          Fax: (301) 984-2286.

           CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS

You should be aware that this prospectus contains forward-looking statements
about, among other things, the anticipated operations, product development,
financial condition and operating results of Nymox, proposed clinical trials and
proposed transactions, including collaboration agreements.

By forward-looking statements, we mean any statements that are not statements of
historical fact, including (but are not limited to) statements preceded by or
that include the words, "believes", "expects", "anticipates", "hopes", "targets"
or similar expressions.

In connection with the "safe harbor" provisions in the Private Securities
Litigation Reform Act of 1995, we are including this cautionary statement to
identify some of the important factors that could cause Nymox's actual results
or plans to differ materially from those projected in forward-looking statements
made by, or on behalf of, Nymox. These factors, many of which are beyond the
control of Nymox, include Nymox's ability to:

     -    identify and capitalize on possible collaboration, strategic
          partnering or divestiture opportunities,

     -    obtain suitable financing to support its operations and clinical
          trials,

     -    manage its growth and the commercialization of its products,


                                       5




<PAGE>   8
     -    achieve operating efficiencies as it progresses from a
          development-stage to a later-stage biotechnology company,

     -    successfully compete in its markets,

     -    realize the results it anticipates from the clinical trials of its
          products,

     -    succeed in finding and retaining joint venture and collaboration
          partners to assist it in the successful marketing, distribution and
          commercialization of its products,

     -    achieve regulatory clearances for its products,

     -    obtain on commercially reasonable terms adequate product liability
          insurance for its commercialized products,

     -    adequately protect its proprietary information and technology from
          competitors and avoid infringement of proprietary information and
          technology of its competitors,

     -    assure that its products, if successfully developed and commercialized
          following regulatory approval, are not rendered obsolete by products
          or technologies of competitors and

     -    not encounter problems with third parties, including key personnel,
          upon whom it is dependent.

Although Nymox believes that the forward-looking statements contained in this
registration statement are reasonable, it cannot ensure that its expectations
will be met. These statements involve risks and uncertainties. Actual results
may differ materially from those expressed or implied in these statements.
Factors that could cause such differences include, but are not limited to, those
discussed under "Risk Factors."

                                  RISK FACTORS

An investment in shares of common stock of Nymox involves a high degree of risk.

You should carefully consider each of the risks and uncertainties described
below along with all of the other information in this prospectus before deciding
to invest in these shares.

IT IS UNCERTAIN WHEN, IF EVER, WE WILL MAKE A PROFIT.

We first began operations in 1995 and are only in the early stages of commercial
marketing of our diagnostic test, the AD7C(TM) test. We have never made a
profit. We incurred a net loss of CAN$6.9 million in 1998 and CAN$3.5 million
for the first nine months of 1999. As of September 30, 1999, Nymox's accumulated
deficit was CAN$21.2 million.

                                       6



<PAGE>   9

We cannot say when, if ever, Nymox will become profitable. Profitability will
depend on our uncertain ability to generate revenues from the sale of our
products and the licensing of our technology that will offset the significant
expenditures required for us to advance our research, protect and extend our
intellectual property and develop, manufacture, license, market, distribute and
sell our technology and products successfully. Similar types of expenditures in
the past have helped produce the net losses reported above.

WE MAY NOT BE ABLE TO RAISE ENOUGH CAPITAL TO DEVELOP AND MARKET OUR PRODUCTS.

Nymox has funded its operations primarily by selling shares of its common stock.
Since late 1998, a small portion of the funds came from service revenues.
However, service revenues have not been, and may not be in the foreseeable
future, sufficient to meet our anticipated financial requirements.

We will continue to need to raise substantial amounts of capital for our
business activities including our research and development programs, the conduct
of clinical trials needed to obtain regulatory approvals and the marketing and
sales of our products. Additional financing may not be available when needed,
or, if available, may not be available on acceptable terms. If adequate funds on
acceptable terms are not available, we may have to curtail or eliminate
expenditures for research and development, testing, clinical trials, promotion
and marketing for some or all of our products.

WE FACE CHALLENGES IN DEVELOPING AND IMPROVING OUR PRODUCTS.

The pharmaceutical and diagnostic industries are driven by rapid technological
and scientific developments and changing customer needs. Nymox's success
depends, in large part, on its ability to respond to our customers' requirements
in a timely manner by developing or acquiring rights to new products or
improvements to our existing products. We are still developing many of our
products and have not yet brought them to market. We cannot assure you that we
will be able to develop or acquire rights to such products and to market them
successfully.

WE FACE SIGNIFICANT AND GROWING COMPETITION.

Rapidly evolving technology and intense competition are the hallmarks of modern
pharmaceutical and biotechnology industries. Our competitors include:

     -    major pharmaceutical, diagnostic, chemical and biotechnology
          companies, many of which have financial, technical and marketing
          resources significantly greater than ours;

     -    biotechnology companies, either alone or in collaborations with large,
          established pharmaceutical companies to support research, development
          and commercialization of products that may be competitive with ours;
          and


                                       7
<PAGE>   10

     -    academic institutions, government agencies and other public and
          private research organizations which are conducting research into
          Alzheimer's disease and which increasingly are patenting, licensing
          and commercializing their products either on their own or through
          joint ventures.

WE MAY NOT BE ABLE TO SUCCESSFULLY MARKET OUR PRODUCTS.

To increase our marketing, distribution and sales capabilities both in the
United States and around the world, we will need to enter into licensing
arrangements, contract sales agreements and co-marketing deals. We cannot assure
you that we will be able to enter into agreements with other companies on terms
acceptable to us, that any licensing arrangement will generate any revenue for
the company or that the costs of engaging and retaining the services of a
contract sales organization will not exceed the revenues generated.

OUR PRODUCTS AND SERVICES MAY NOT RECEIVE NECESSARY REGULATORY APPROVALS.

Our AD7C(TM) testing service and our products in development are subject to a
wide range of government regulation governing laboratory standards, product
safety and efficacy. The actual regulatory schemes in place vary from country to
country and regulatory compliance can take several years and involve substantial
expenditures.

We cannot be sure that we can obtain necessary regulatory approvals on a timely
basis, if at all, for our products in development and all of the following could
have a material adverse effect on our business:

     -    failure to obtain or significant delays in obtaining requisite
          approvals;

     -    loss of or changes to previously obtained approvals; and

     -    failure to comply with existing or future regulatory requirements.

The operation of our clinical reference laboratory in Maryland is regulated by
the Health Care Financing Administration (HCFA) under the Clinical Laboratories
Improvement Act of 1988. In addition, individual states like New York and
Maryland have their own requirements for reference laboratories like ours that
offer diagnostic services. In addition, the United States Food and Drug
Administration (FDA) has its own regulations governing in vitro diagnostic
products, including some of the reagents used in clinical reference
laboratories. Any changes in HCFA or state law requirements or in the FDA
regulations could have a detrimental impact on our ability to offer or market
any reference laboratory services and/or on our ability to obtain reimbursement
from the Medicare and Medicaid programs and providers.


                                       8
<PAGE>   11

Our diagnostic product in development, 7C Gold, will require prior approval from
the FDA before being marketed, distributed and sold in the United States.
Similar requirements exist in many other countries. In general, such approval
requires clinical testing as to the safety and efficacy of the device and
preparation of an approval application with extensive supporting documentation.
If approved, the device would then be subject to postmarketing record and
reporting obligations and manufacturing requirements. Obtaining these approvals
and complying with the subsequent regulatory requirements can be both
time-consuming and expensive.

In the United States, our drugs in development will require FDA approval, which
comes only at the end of a lengthy, expensive and often arduous two-step
process. We cannot predict with any certainty the amount of time the FDA will
take to approve one of our drugs or even whether any such approval will be
forthcoming. Similar requirements exist in many other countries.

PROTECTING OUR PATENTS AND PROPRIETARY INFORMATION IS COSTLY AND DIFFICULT.

We believe that patent and trade secret protection is important to our business,
and that our success will depend, in part, on our ability to obtain strong
patents, to maintain trade secret protection and to operate without infringing
the proprietary rights of others.

The commercial success of products incorporating our technologies may depend, in
part, upon our ability to obtain strong patent protection. We cannot assure you
that additional patents covering new products or improvements will be issued or
that any new or existing patents will be of commercial benefit or be valid and
enforceable if challenged.

HEALTH CARE PLANS MAY NOT COVER OR ADEQUATELY PAY FOR OUR PRODUCTS AND SERVICES.

Throughout the developed world, both public and private health care plans are
under considerable financial and political pressure to contain their costs. The
two principal methods of restricting expenditures on drugs and diagnostic
products and services are to deny coverage or, if coverage is granted, to limit
reimbursement. For single-payer government health care systems, a decision to
deny coverage or to severely restrict reimbursement for one of our products can
have an adverse effect on our business and revenues.

In the United States, where, to a significant degree, the patient population for
our products is elderly, Medicare and Medicaid are sources of reimbursement. In
general, any restriction on reimbursement, coverage or eligibility under either
program could adversely affect reimbursement to Nymox for products and services
provided to beneficiaries of the Medicare and/or Medicaid programs. Many elderly
people are covered by a variety of private health care organizations either
operating private health care plans or Medicare or Medicaid programs subject to
government regulation. These organizations are also under considerable financial
constraints and we may not be able to secure coverage or adequate reimbursement
from these organizations. Without coverage, we will have to look to the patients
themselves who may be unwilling or unable to pay for the product; in turn,
doctors may be reluctant to order or prescribe our products in the absence of
coverage of the product for the patient.


                                       9
<PAGE>   12

THE FUTURE SALE OF ELIGIBLE SHARES MAY DILUTE NYMOX'S STOCK PRICE.

The issuance of further shares and the eligibility of issued shares for sale
will dilute our common stock and may lower its share price. There are 20,003,804
common shares of Nymox currently issued and outstanding, not including the
Shares covered by this prospectus. All but 36,600 of these shares are eligible
for sale under Rule 144 or are otherwise freely tradable. Finally, 1,130,500
share options are outstanding, of which 891,000 are currently vested. The great
majority of these options expire in 6 to 10 years. These options have been
granted to employees, officers, directors and consultants of the company.
Moreover, Nymox may use its shares as currency in acquisitions.

WE FACE POTENTIAL LOSSES DUE TO FOREIGN CURRENCY EXCHANGE RISKS.

A large portion of the corporation's expenses are derived in U.S. dollars. As a
result, we are exposed to the risk of losses due to fluctuations in the exchange
rates between the United States dollar and the Canadian dollar. We protect
ourselves against this risk by maintaining cash balances in both currencies. We
do not currently engage in hedging activities. We cannot say with any assurance
that the company will not suffer losses as a result of unfavorable fluctuations
in the exchange rates between the United States dollar and Canadian dollar.

WE HAVE NEVER PAID A DIVIDEND AND ARE UNLIKELY TO DO SO IN THE FORESEEABLE
FUTURE.

Nymox has never paid any dividends and does not expect to do so in the
foreseeable future. We expect to retain any earnings or positive cash flows in
order to finance and develop Nymox's business.


                                       10
<PAGE>   13

                        TRADING MARKET FOR COMMON SHARES

Nymox's common shares trade on the Nasdaq Stock Market. Nymox's common shares
traded on the Nasdaq National Market from December 1, 1997 until September 16,
1999 when they began trading on the Nasdaq SmallCap Market. Nymox's common
shares also traded on the Montreal Exchange from December 18, 1995 until
November 19, 1999.

The following tables set out the high and low reported trading prices of the
common shares on the Nasdaq Stock Market during the periods indicated.

<TABLE>
<CAPTION>
- ------------------- ------------------------- ------------------------------ ------------------------------
Year                Quarterly Period                High Sales Price               Low Sales Price
- ------------------- ------------------------- ------------------------------ ------------------------------
<S>                <C>                                   <C>                            <C>
       1997         4th Quarter                           $8.75                          $6.25
- ------------------- ------------------------- ------------------------------ ------------------------------
       1998         1st Quarter                          $13.625                        $5.688
                    ------------------------- ------------------------------ ------------------------------
                    2nd Quarter                          $8.375                          $5.75
                    ------------------------- ------------------------------ ------------------------------
                    3rd Quarter                          $7.375                         $2.5625
                    ------------------------- ------------------------------ ------------------------------
                    4th Quarter                           $6.25                          $2.50
- ------------------- ------------------------- ------------------------------ ------------------------------
       1999         1st Quarter                          $5.875                         $2.875
                    ------------------------- ------------------------------ ------------------------------
                    2nd Quarter                          $4.188                          $2.75
                    ------------------------- ------------------------------ ------------------------------
                    3rd Quarter                          $4.750                          $2.50
                    ------------------------- ------------------------------ ------------------------------
                    4th Quarter                          $4.625                          $2.50
- ------------------- ------------------------- ------------------------------ ------------------------------
</TABLE>

According to information furnished to Nymox by the transfer agent for the common
shares, as of January 31, 2000, total shares outstanding were 20,003,804. There
were 891 holders of record of the common shares and 3,261 beneficial
shareholders in total. Of these, 90 were holders of record of the common shares
and 1,304 were beneficial shareholders with addresses in the United States and
such holders owned an aggregate of 1,886,798 shares, representing 9.4% of the
outstanding shares of common stock.

                      SELECTED CONSOLIDATED FINANCIAL DATA

The following table sets forth selected consolidated financial data for Nymox
for the periods indicated, derived from financial statements prepared in
accordance with generally accepted accounting principles ("GAAP"). The financial
data for the years ended December 31, 1996, 1997 and 1998, has been extracted
from audited financial statements included elsewhere in this registration
statement. The financial data for the 1994 and 1995 (July and December) periods
has been extracted from audited financial statements not included in this
prospectus.

The selected financial data as at and for the nine months ended September 30,
1999 has been extracted from unaudited financial statements included elsewhere
in this prospectus. Such unaudited financial statements include all adjustments
(consisting of normal recurring adjustments) which, in the opinion of
management, are necessary for a fair presentation of the information for the
period presented.

We prepare our basic financial statements in accordance with Canadian GAAP and
include, as a note to the statements, a reconciliation of material differences
to United States GAAP.

                                       11
<PAGE>   14
Effective August 1, 1995, Nymox changed its fiscal year from a July 31 year-end
to a December 31 year-end.

NYMOX PHARMACEUTICAL CORPORATION
Selected Consolidated Financial Data
(expressed in Canadian dollars)

<TABLE>
<CAPTION>

                                                                                                        9 Months
                                                                                                         ending
                              July 31,    July 31,     Dec. 31,                                         Sept. 30,
                                1994        1995         1995      Dec. 31,    Dec. 31,     Dec. 31,      1999
                             (12 months) (12 months)  (5 months)      1996        1997        1998     (Unaudited)
                             ----------- ----------- ------------ ----------- ----------- ------------ -----------
<S>                            <C>         <C>         <C>         <C>         <C>          <C>         <C>
Canadian GAAP

   Current Assets               -  0  -      11,963    2,268,097   2,896,234   2,526,335    3,909,241   1,855,966

   Capital Assets                12,576     338,953      366,155   1,317,973   1,419,462    1,846,979   1,610,772

   Total Assets                 239,403     350,916    2,634,252   4,214,207   3,945,797    5,756,220   3,466,738

   Total Liabilities             95,376     121,589      151,297     384,226     292,330      434,440     275,667

   Shareholders' Equity         194,027     229,327    2,482,955   3,829,981   3,653,467    5,321,780   3,191,071

   Revenues                     -  0  -     -  0  -      -  0  -     226,940     101,110      394,837     220,912

   Research & Development
     Expenditures (note 1)       55,325     371,939      571,215   2,116,000   2,412,349    3,013,237   1,221,866

   Net Loss                      58,325     377,570      693,846   3,699,064   4,999,455    6,903,611   3,479,058

   Loss per Share (note 2)      -  0  -        0.03         0.04        0.21        0.27         0.36        0.17

U.S. GAAP (note 3)

   Net Loss                      71,668     393,841    1,639,194   4,330,230   5,198,988    7,385,188   3,551,140

   Loss per Share (note 2)       - 0  -        0.03         0.11        0.25        0.28         0.38        0.18

   Shareholders' Equity         127,312     146,341    2,391,515   3,107,375   2,731,328    3,918,064   1,715,273
</TABLE>

Notes:
1)   We earn investment tax credits by making qualifying research and
     development expenditures. These amounts shown are net of investment tax
     credits.
2)   For periods prior to December 31, 1995, the number of shares outstanding is
     assumed to be 15,000,000 representing the number of shares issued by Nymox
     to DMS Pharmaceuticals Inc. in September 1995. Nymox has never paid
     dividends on its common stock.
3)   Reference is made to Note 10 of Nymox's audited financial statements as at
     and for the year ended December 31, 1998 for a reconciliation of
     differences between Canadian and U.S. GAAP.

                                       12



<PAGE>   15

                          INFORMATION ABOUT THE COMPANY

DIAGNOSTIC PRODUCTS FOR ALZHEIMER'S DISEASE

Alzheimer's disease is the most common cause of dementia in persons 65 years of
age and older and is the fourth leading cause of death among the elderly.
Despite the need for an accurate clinical test, the definitive diagnosis of the
disease is possible only after the death of the patient by expert, pathologic
examination of brain tissue.

The Surgeon General's Report on Mental Health, released on December 13, 1999,
identified the importance and the need for the early detection and diagnosis of
Alzheimer's disease. The report described the current approach to Alzheimer's
disease diagnosis, clinical examination and the exclusion of other common causes
of its symptoms, as time- and labor-intensive, costly and largely dependent on
the expertise of the examiner. As a result, the illness is currently
underrecognized, especially in primary care settings, where most older patients
seek care. The report joined other experts writing in the field in recognizing
the need for a better, more reliable method for diagnosing the disease in living
patients and in particular, the need of a simple, accurate and convenient test
that could detect a biochemical change early in patients with Alzheimer's
disease. We believe our AD7C(TM) provides such a test.

The AD7C(TM) Test measures the level of a brain protein called neural thread
protein which is elevated early in Alzheimer's disease as reported both in the
scientific literature and at scientific conferences. Researchers at the
Massachusetts General Hospital and Brown University led by Doctors Suzanne de la
Monte and Jack Wands first found large amounts of the protein in the brains of
patients known to have died with Alzheimer's disease. Subsequent research led to
the characterization of the protein and the development of a highly sensitive
test to detect the presence of the protein not only in brain tissue but also in
the spinal fluid and urine of patients diagnosed with Alzheimer's disease. There
is evidence that the protein is associated with the growth and sprouting of
brain cells and accordingly one possible explanation for its increased
production in the brains of patients with Alzheimer's disease may be as one of
the body's responses to the widespread destruction of brain cells that occurs
with AD. The protein is also associated with cell death in brain cell cultures
in the laboratory and therefore may also play a role in the cell loss in the
disease.

Nymox believes that its AD7C(TM) test can assist a physician faced with the task
of diagnosing whether a patient has Alzheimer's disease. In company funded
trials to date, involving over 500 clinical samples, the test results were
positive for over 80% of the patients with verified Alzheimer disease and
negative in over 89% of subjects without the disease (known as a low false
positive rate). The low rate of positive results for patients without the
disease is important for doctors investigating patients with subtle or marginal
symptoms of mental, emotional, cognitive, or behavioral changes. If the doctor
can rule out Alzheimer's with more assurance, a great deal of patient and family
anguish and anxiety will be avoided. A low test score will help the doctor to be
more certain that Alzheimer's disease is not the cause of the patient's symptoms
and to target the other, often reversible causes of the patient's symptoms, such
as depression.


                                       13



<PAGE>   16
These trials have been confirmed by verification of the diagnosis through
postmortem examination of brain tissue. To date, several studies published in
scientific publications or presented at scientific conferences have confirmed
the accuracy of the AD7C(TM) test. These publications include the Journal of
Clinical Investigation (1997; vol.100; pages 3093-3104), the Journal of
Contemporary Neurology (1998; art. 4a) and two publications in the Journal of
Clinical Laboratory Analysis (1998; vol.12: 285-288) and (1998; vol.12:223-226).

There can be no assurance that further studies will repeat the same level of
success experienced to date.

Nymox provides the AD7C(TM) test for both spinal fluid and urine samples through
its reference laboratory in Kensington, Maryland. A patient provides the
necessary sample to his or her doctor who then forward the sample to our
laboratory where our technical staff performs the tests. We then report the
results to the doctor.

The AD7C(TM) test is an aid to diagnosis, to be considered together with patient
history, physical examination and other relevant medical data. The test does not
replace a physician's diagnosis. We believe that the appropriate use of the test
leads to better, earlier and quicker diagnoses and associated cost-savings
through the elimination of unnecessary and intrusive tests and examinations.

Nymox is developing an improved version of the AD7C(TM) test known as 7C Gold.
The 7C Gold test when completely developed will permit the testing of urine or
spinal fluid samples in a general purpose medical laboratory or a doctor's
office rather than in a highly specialized reference laboratory. We expect that
the 7C Gold test will increase the availability and acceptance of our test while
lowering its cost to the patient or health care payer.

Nymox also is developing a new diagnostic test for Alzheimer's disease that
detects a distinctive brain antigen referred to as 35i9 which we believe is also
associated with Alzheimer's disease.

DEVELOPMENT OF THERAPEUTIC PRODUCTS FOR ALZHEIMER'S DISEASE

At present, there is no cure for Alzheimer's disease. There are two drugs
approved by the FDA, tacrine (brand-name Cognex) and donezepil (brand-name
Aricept) for the treatment of Alzheimer's disease. However, at most these drugs
offer symptomatic relief for the loss of mental function associated with the
disease and possibly help to delay the illness-progression. There is no
consensus as to the cause of Alzheimer's disease or even whether it is one
disease or many.


                                       14



<PAGE>   17

There is an urgent need for an effective treatment for the illness, caused in
part by the rising health care, institutional and social costs for the treatment
and care of Alzheimer's disease sufferers. The Surgeon General's Report on
Mental Health released on December 13, 1999, put the direct health care costs
for the illness in the United States at almost $18 billion for 1996. In a 1998
statement to the House Appropriations Subcommittee, the Director of the National
Institute on Aging, Dr. Richard J. Hodes, estimated that the cost of care to
family, caregivers and society in general was as much as $100 billion per year.

These costs are expected to rise sharply as the baby boom generation ages and
more people become at risk for the disease. According to Dr. Hodes, the number
of Americans aged 65 or over, now some 34 million, is expected to more than
double by year 2030. Within this group, the population of persons over the age
of 85 is the fastest growing segment. As people live longer, they become more at
risk of developing Alzheimer's disease.

Nymox's research into drug treatments for Alzheimer's disease is aimed at
compounds that could arrest the progression of the disease and therefore are
targeted for long term use.

Nymox researchers believe that spherons are the cause of senile plaques, the
characteristic injury found in the brains of patients suffering from Alzheimer's
disease and widely believed to be at the root of the illness. Spherons are
unique, microscopic-sized balls of protein found in every person's brain from
age 1. As we age, our spherons grow larger until the cells they are in can no
longer hold them. Nymox researchers believe that, once freed, the spherons burst
to form senile plaques and so set off a chain of events leading to the loss of
brain cells and brain function associated with Alzheimer's disease. In 1998,
Nymox researchers summarized their findings in the Journal of Alzheimer's
Disease and in IOS Press - Drug News & Perspectives. These summaries set forth
20 important criteria of validity correlating the disappearance of spherons in
old age with the appearance of senile plaques and implicating spherons as the
cause of Alzheimer's disease

Based on these research findings, Nymox developed proprietary screening systems
and used them to discover, develop and test drug candidates to inhibit the
formation of Alzheimer plaques from spherons. These candidates have the
potential to slow or stop the progression of the disease. Its most promising
compound, NXD-2858, has shown the capability of being taken orally and of
crossing the blood-brain barrier into the brain. To date, this compound shows no
significant evidence of toxicity or significant potential side effects. Nymox
also has two other distinct new drug candidates, NXD-3109 and NXD-1191, neither
of which demonstrate significant toxicity and both of which had positive animal
testing results.

Nymox also developed a unique drug screening system, based on the research that
led to its AD7C(TM) test, to identify other potential drug candidates for the
treatment of Alzheimer's disease. Dr. Suzanne de la Monte and other researchers
at the Massachusetts General Hospital identified the gene that produces neural
thread protein, the brain protein detected by Nymox's AD7C(TM) test. In this
system, researchers inserted the AD7C gene into human brain cells, triggering
the production of the AD7C brain protein associated with Alzheimer's disease.
The genetically-altered cells then begin to sprout new growths, start to
degenerate and finally die prematurely. Nymox screened compounds for their
ability to impede this process of premature cell death and thus potentially slow
or halt the loss of brain cells in the Alzheimer's disease brain. Nymox licensed
this technology in 1997 from the Massachusetts General Hospital as part of a
sponsored research and licensing agreement.


                                       15
<PAGE>   18

In November, 1999, Dr. Ben Wolozin of Loyola University Medical Center in
Chicago reported at the annual meeting of the Society for Neuroscience his
findings that some members of a class of anti-cholesterol drugs called statins
may delay or prevent the onset of Alzheimer's disease. Dr. Wolozin licensed the
commercial and patent rights to this discovery to Nymox.

ANTI-INFECTIVES

In the last ten years there has been a growing recognition of the increasing
problem of antibiotic-resistant infections and the need for truly novel
antibacterial drugs. A recent example of this recognition can be found in the
European Commission report dated May 28, 1999, "Opinion of the Scientific
Steering Committee on Antimicrobial Resistance."

In the field of infectious disease treatments, Nymox has developed three new
antibacterial agents:

     -    NXB-4221 for the treatment of difficult chronic and persistent urinary
          tract infections;

     -    NXB-5886 for the treatment of streptococcal infection; and

     -    NXT-1021 for the treatment of staphylococcal infection.

Urinary tract infections in women caused by bacteria such as E. coli have become
increasingly resistant to conventional antibiotic treatment. Some varieties of
streptococcus and staphylococcus bacteria, a common source of infection in
humans, have acquired a broad immunity to antibiotic treatments. Infections from
these antibiotic resistant bacteria are difficult to treat and can be life
threatening. Nymox's three antibacterial agents have all shown the ability to
kill their bacterial targets in culture with no signs of toxicity.

E. coli contamination of food and drink is a serious public health problem
worldwide and a major concern for meat processors in particular. E. coli
bacteria occur normally and usually harmlessly in the gastrointestinal tracts of
humans, cows and other animals. However, one mutant variety of the E. coli
bacteria, E. coli 0157:H7, can cause life-threatening illness and has been
implicated in cases of severe diarrhea, intestinal bleeding and kidney failure,
leading, in some cases, to death in children and the elderly. E. coli
contamination in hamburger meat and other food products and in drinking water
affects about 100,000 people a year.


                                       16
<PAGE>   19

Nymox developed a potent new antibacterial agent, NXC-4720. Tests of NXC-4720
show it to be highly effective against all known substrains of E. coli 0157:H7,
the bacteria implicated in these severe cases of food and drink contamination.
Tests of NXC-4720 show that it destroys E. coli 0157 strains, including H7,
efficiently, rapidly and at a very low dose. In 1999, we began further trials
for this agent and expect to complete them in 2000. Nymox has patent rights to
these and other antibacterial agents.

COMPETITION

In the field of Alzheimer's disease diagnosis, our AD7C(TM) Test faces growing
competition which could detrimentally impact on our ability to successfully
market and sell our diagnostic test. Our competitors include:

     -    Athena Diagnostics, Inc. which is currently marketing three tests
          claimed to aid in the diagnosis of Alzheimer's disease: a genetic test
          for the rare cases of familial, early-onset Alzheimer's disease; a
          genetic test for a relatively common mutation of a gene said to
          increase the likelihood of a person with at least one of the genes
          contracting the disease; and a test for two proteins in the spinal
          fluid of patients.

     -    Mitokor, Inc. which developed a blood test known as Mito-Load that
          looks for certain mutations in mitochondrial DNA said to be associated
          with Alzheimer's disease. Mitokor recently entered into a
          non-exclusive licensing agreement in Japan for the marketing and sale
          of its product there.

     -    Synapse Technologies, Inc. which developed a blood test known as p97
          Diagnostic that detects a protein said to be diagnostic of Alzheimer's
          disease. Synapse Technologies also licensed its technology for use in
          Japan.

     -    NeuroLogic, Inc. announced in September, 1999 that it acquired an
          exclusive world-wide license to a cellular test for Alzheimer's
          disease.

There are also a number of other proposed biochemical signs of the disease that
could potentially be developed into a commercial diagnostic test as well as
various scanning and imaging technologies which might compete some day for a
portion of the diagnostic market for Alzheimer's disease.

We also face intense competition for the development of an effective treatment
for Alzheimer's disease. The market conditions for an Alzheimer's disease drug
strongly favor the entry of other corporations into the area. The current market
for therapeutic drugs for Alzheimer's disease is an estimated $2 billion. This
market is expected to grow rapidly as new drugs enter the market and as the baby
boom generation becomes more at risk for developing Alzheimer's disease. As a
result, most of the major pharmaceutical companies and many biotechnology
companies have ongoing research and development programs for drugs and
treatments for Alzheimer's disease. Many of these companies have much greater
scientific, financial and marketing resources than we have and may succeed in
developing and introducing effective treatments for Alzheimer's disease before
we can. At present, only one drug for Alzheimer's disease is being widely
marketed in the United States, Aricept by Pfizer. Aricept only treats some of
the symptoms of Alzheimer's disease by enhancing memory and other mental
functions and not the underlying causes of the illness.


                                       17
<PAGE>   20

A similar competitive reality prevails in the field of novel anti-infectives.
Over the past ten years, there has been an increasing awareness of the medical
need and of emerging market opportunities for new treatments for antibiotic
resistant bacterial infections. Many of the major pharmaceutical companies are
developing anti-infective drugs that either modify their existing drugs or
involve new anti-bacterial properties. Many biotechnology companies are
developing new classes of anti-bacterial drugs. At least three major
pharmaceutical companies have vaccines against bacterial infections in
development. To the extent that these companies are able to develop drugs or
vaccines that offer treatment for some or all of the indications for our
anti-infectives, the market for our products may be adversely affected.

The problem of E. coli 0157:H7 contamination of hamburger meat and other food
products is also well-known and a number of companies and researchers have been
pursuing various potential solutions, including irradiation with x-rays, better
detection of contamination, electronic pasteurization, vaccination and
competitive exclusion of the pathogenic E. coli bacteria by harmless bacteria.
The development of alternative solutions to the problem of E. coli infection may
adversely affect the market for our treatment for E. coli 0157:H7 infection in
cattle and contamination of food products.

GOVERNMENT REGULATION

Any therapeutic product developed by Nymox would have to receive regulatory
approval. In the United States, once a product receives regulatory approval to
begin clinical testing, it must go through four distinct development and
evaluation stages:

     - Product Evaluation.

     Nymox must conduct preliminary studies of potential drug candidates using
     various screening methods to evaluate their products for further testing,
     development and marketing.

     - Optimization of Product Formulation.

     The activities in this stage of development involve consultations between
     the Company and investigators and scientific personnel. Preliminary
     selection of screening candidates to become product candidates for further
     development and further evaluation of drug efficacy is based on a panel of
     research based biochemical measurements. Extensive formulation work and in
     vitro testing are conducted for each of various selected screening
     candidates and/or product candidates.


                                       18
<PAGE>   21

     - Clinical Screening and Evaluation.

     During this phase of development, portions of which may overlap with
     product evaluation and optimization of product formulation, initial
     clinical screening of product candidates is undertaken and full scale
     clinical trials commence.

     - Final Product Development.

     The activities to be undertaken in final product development include
     performing final clinical evaluations, conducting large-scale experiments
     to confirm the reproducibility of clinical responses, making clinical lots
     for any additional extensive clinical testing that may be required,
     performing any further safety studies required by the FDA, carrying out
     process development work to allow pilot scale production of the product,
     completing production demonstration runs for each potential product, filing
     new drug applications, product license applications, investigational device
     exemptions (and any necessary supplements or amendments) and undergoing
     comprehensive regulatory approval programs and processes.

Nymox cannot assure you that it will successfully complete the development and
commercialization of any therapeutic products.

PROPERTY

Our laboratory facilities in Kensington, Maryland comprise 5,504 square feet of
leased space. The lease expires on March 31, 2000. Our office and research
facilities in Saint Laurent, Quebec, Canada comprise 6,923 square feet of leased
space. The lease agreement expires on August 31, 2003. Nymox owns a full
complement of equipment used in all aspects of its research and development work
and its reference laboratory. Nymox believes that its facilities are adequate
for its current needs and that additional space, if required, would be available
on commercially reasonable terms.

LEGAL PROCEEDINGS

Nymox's United States subsidiary, Nymox Corporation, commenced an action against
a former employee, Hossein Ali Ghanbari, in Montgomery County, Maryland, for
repayment of two promissory notes. On August 5, 1999, the court granted Nymox
Corporation's Motion for Partial Summary Judgment in the sum of $168,731.83.

Hossein Ali Ghanbari has made counterclaims against Nymox Corporation. On
February 3, 2000, the large majority of these counterclaims were dismissed on a
motion for summary dismissal. The remaining counterclaims allege that Nymox
Corporation allegedly defamed Ghanbari, that Nymox Corporation wrongfully
discharged Ghanbari and that Nymox Corporation failed to apply on time to the
Province of Quebec for a tax holiday for Ghanbari. Ghanbari has claimed that he
is entitled to compensatory damages totaling $10.5 million and punitive damages
totaling $10 million. Nymox Corporation denies the allegations raised in the
counterclaims, believes the counterclaims lack merit and is vigorously defending
these counterclaims.

                                       19
<PAGE>   22

                      MANAGEMENT'S DISCUSSION AND ANALYSIS
                OF RESULTS OF OPERATIONS AND FINANCIAL CONDITION

OVERVIEW

We are a development stage biopharmaceutical company that specializes in the
research and development of therapeutics and diagnostics for the aging
population with an emphasis on Alzheimer's disease.

We market and provide a clinical laboratory test, the AD7C(TM) test that is an
aid to the diagnosis of Alzheimer's disease. We have under development an
improved version of the AD7C(TM) test, 7C Gold, which, when completed and
approved, can be used in a general purpose medical laboratory or a doctor's
office rather than in a highly specialized reference laboratory.

We also have under development therapeutic agents for the treatment of
Alzheimer's disease and of certain antibiotic-resistant infections as well as
antibacterial agents for E. coli contamination of food and drink products.

We began generating revenue from sales of our AD7C(TM) test in 1997.

LIQUIDITY AND CAPITAL RESOURCES

We fund our operations and projects primarily by selling shares of Nymox's
common stock. However, since 1997, a small portion of our funding came from
service revenues. This source of funding became more significant in late 1998,
following the launch of our urinary version of the AD7C(TM) test. Since its
incorporation in May, 1995, Nymox raised the capital necessary to fund its
on-going research and development work and its marketing and sales operations
primarily through private placements of its shares.

In December 1995, Nymox completed an initial private placement of 1,578,635
common shares at a price of CAN$2.00 per share for CAN$3,157,270 to finance its
activities.

On December 18, 1995, the shares of Nymox were listed on the Montreal Stock
Exchange. Since then, the private placements completed by Nymox are as follows:

     -    April 1996, 877,300 common shares at a per share price of CAN$6.00 for
          aggregate net proceeds of CAN$5,263,800;

     -    May 1997, 696,491 common shares at a price of CAN$6.50 and warrants
          exercisable at a price of CAN$8.50 per share for a total consideration
          of CAN$4,527,191. In 1998, all 696,491 of these warrants were
          exercised for additional proceeds to Nymox of CAN$5,920,174;


                                       20
<PAGE>   23

     -    May 1998, 231,630 common shares at a price of CAN$8.50 for total
          proceeds of CAN$1,968,855. A total of 110,000 warrants were issued as
          well, exercisable at prices of CAN$8.50 per share (50,000) and
          CAN$10.00 per share (60,000). These warrants have since expired;

     -    January, 1999, 190,000 common shares at CAN$8.50 per share, for total
          proceeds of CAN$1,615,000. A total of 95,000 warrants were issued as
          well, exercisable at the price of CAN$10.00 per share. These warrants
          have since expired; and

     -    September, 1999, 122,000 common shares at CAN$5.00 per share, for
          total proceeds of CAN$610,000

In total, Nymox has raised over CAN$24 million, since its incorporation in May
1995.
We expect the stock purchase agreement with Jaspas, described below in the
section entitled "The Common Stock Purchase Agreement", to provide significant,
long-term financing that will enable us to advance our research and product
development for the next three years. We plan to seek additional capital within
the limits on financing contained in the common stock purchase agreement in
order to accelerate product development and marketing and obtaining necessary
regulatory approvals.
We have no financial obligations of significance other than long-term lease
commitments for our premises in Canada and the United States of CAN$27,562 per
month and ongoing research funding payments to a U.S. medical facility totaling
$172,000 for 1999.

RESULTS OF OPERATIONS
NINE MONTHS ENDED SEPTEMBER 30, 1999 COMPARED TO NINE MONTHS ENDED
SEPTEMBER 30, 1998
Revenue
In the last quarter of 1998, we launched our urinary version of the AD7C(TM)
test. This resulted in a 196% increase in our revenues from this service from
CAN$60,135 for the nine months ending September 30, 1998 to CAN$178,496 for the
same period in 1999. This increase is attributable to more sales of our AD7C(TM)
test.
Our 7C Gold test successfully completed its initial key validation studies in
September 1999 and we plan to apply for FDA approval in 2000. We expect that
approval of the 7C Gold test will have a positive impact on the acceptance of
our test in the medical and health care communities and on our marketing and
sales.


                                       21
<PAGE>   24
Expenses
We were able to reduce expenses from CAN$5,510,528 for the nine months ending
September 30, 1998 to CAN$3,767,349 for the same period in 1999. The two
principal areas of savings were in marketing, with a reduction in expenditures
from CAN$2,570,594 to CAN$1,057,545 and, to a lesser extent, in research and
development, from CAN$2,198,823 to CAN$1,241,011. These savings were partly
offset by a rise in general, administrative and cost of sales from CAN$608,894
to CAN$1,305,242. This rise is attributable to an increase in cost of sales of
CAN$258,252 resulting from the increase in sales of the AD7C(TM) test, in
professional fees of CAN$287,540, mostly legal fees, and in salaries of
CAN$150,000 (re: hiring of an additional executive level employee).

The result of an increase in revenue and a decrease in expenses was a decline in
the net loss per share from CAN$0.27 for the nine months ending September 30,
1998 to CAN$0.17 for the nine months ending September 30, 1999.

LIQUIDITY AND CAPITAL RESOURCES

As of September 30, 1999, cash, short term investments and subscriptions
receivable totaled CAN$1,335,765. We invested CAN$136,418 in additional capital
assets in the nine months ended September 30, 1999, consisting mostly of patent
costs, compared to CAN$298,169 in the same period in 1998. The decrease is
attributable to a reduction in purchases of equipment.

YEAR ENDED DECEMBER 31, 1998 COMPARED TO YEAR ENDED DECEMBER 31, 1997


Revenue

Revenues on service fees for the AD7C(TM) test amounted to Can$151,263 for the
year ended December 31, 1998, compared with CAN$24,584 for the year ended
December 31, 1997. More than half of these revenues were generated in the last
two months of 1998 when we launched the urinary version of our AD7C(TM) urine
test service through our reference laboratory service in Kensington, Maryland.
All of the service fee revenue was derived in the United States.

Interest revenue increased to CAN$243,574 in 1998 compared to CAN$76,526 in
1997, derived from interest earned on the cash and short-term investments
received from the private placements referred to previously.

Expenses

Research and development expenditures amounted to CAN$3,019,015 for the year
ended December 31, 1998, compared with CAN$2,562,349 for the year ended December
31, 1997. The increase is principally attributable to increased expenditures on
reagents and clinical studies related to R&D in therapeutics and anti-infectives
(net increase CAN$476,677) at the Rockville, Maryland laboratory during the
year. In 1998, research tax credits amounted to CAN$5,778 compared to
CAN$150,000 in 1997. The reduction in tax credits is attributable to the
transfer of research and development activities to the United States.

Marketing expenses amounted to CAN$3,240,242 for the year ended December 31,
1998 compared to CAN$1,925,654 for the year ended December 31, 1997. A major
marketing effort in 1998 accounted for the increased expenditures; the effort
focused specifically on mass mailings and publicity (net increase CAN$827,189)
and presentations at conferences (net increase CAN$579,496). We anticipated
reducing expenditures in this area in 1999 and in fact did so.


                                       22
<PAGE>   25
General and administrative expenses amounted to CAN$896,201 for the year ended
December 31, 1998, compared with CAN$589,524 in the year ended December 31,
1997. The increase is attributable to increases in professional fees (net
increase CAN$193,736) and increased costs related to shareholder relations (net
increase CAN$73,146). Increases in both areas result from first time contracts
in 1998 with shareholder relations and public relations firms.

Net losses for the period ended December 31, 1998 were CAN$6,903,611, or
CAN$0.36 per share, compared to CAN$4,999,455, or CAN$0.27 per share, for the
period ended December 31, 1997.

YEAR ENDED DECEMBER 31, 1997 COMPARED TO YEAR ENDED DECEMBER 31, 1996

Expenses

Research and development expenditures represented our most significant
expenditure and amounted to CAN$2,562,349 for the year ended December 31, 1997,
compared with CAN$2,356,000 for the year ended December 31, 1996. The increased
expenses were largely attributable to increased expenditures related to
laboratory expenses (CAN$178,000) at the Rockville, Maryland laboratory during
the year. The Rockville facility was in operation for only 10 months in 1996. We
also paid its third installment under its research and license agreement with
Massachusetts General Hospital in the amount of CAN$311,310, which was
CAN$36,000 higher than the 1996 payment. Under the agreement, we were obligated
to make certain regularly scheduled payments to Massachusetts General as
research grants in exchange for royalties from any sales of resulting products.
Gross research and development expenditures were partially offset by research
tax credits available to us in Quebec. In 1997, research tax credits amounted to
CAN$150,000 compared to CAN$240,000 in 1996. The reduction was attributable to
the transfer of certain research and development activities to the United
States.

Marketing expenses in 1997 amounted to CAN$1,925,654 for the year ended December
31, 1997 compared to CAN$1,253,894 for the year ended December 31, 1996.
Expenditures in 1997 consisted largely of the costs of establishing and
maintaining a sales and marketing force (CAN$1,135,000) and costs related to
marketing activities such as presentations at conferences, publicity, travel,
general expenses, printing and postage (CAN$790,000). Expenditures in 1996,
consisted of publicity related costs in connection with pre-marketing of the
AD7C(TM) test (CAN$746,000), salaries (CAN$178,000) and other costs related to
marketing activities (CAN$330,000).


                                       23
<PAGE>   26

General and administrative expenses amounted to CAN$589,524 for the year ended
December 31, 1997 compared with CAN$497,179 in the year ended December 31, 1996.
The increase was attributable to legal costs and expenses related to United
States public company registration and the NASDAQ listing (CAN$119,600).

INFLATION

We do not believe that inflation has had a significant impact on the results of
our operations.

                                       24
<PAGE>   27


                               RECENT DEVELOPMENTS

ACQUISITION OF A CONTROLLING INTEREST IN SEREX, INC.
On January 8, 2000, we entered into an agreement to acquire a controlling
interest in Serex, Inc. under a share purchase agreement with Dr. Judith
Fitzpatrick, the Chief Executive Officer and majority shareholder of Serex. On
March ____, 2000, we closed this acquisition.
Under the share purchase agreement, we purchased 1,008,250 shares of Serex or
72.3% of the common stock of Serex from Dr. Judith Fitzpatrick in exchange for
187,951 shares of Nymox and warrants to purchase 115,662 shares of Nymox at a
price of $3.70. The acquisition price was based on the closing market price for
Nymox shares as of Nov. 16, 1999 wich was $3.3438.
The Nymox shares and warrants we issued to Dr. Fitzpatrick are subject to
restrictions on their resale or transfer both under United States securities
laws, rules and regulations and under the stock purchase agreement. We agreed to
file a registration statement with the Securities and Exchange Commission
covering the Nymox shares and warrants by November 8, 2000. However, Dr.
Fitzpatrick has also agreed that her Nymox shares would only become eligible for
sale, subject to any restrictions imposed by United States securities laws, in
accordance with the following schedule:

     -    35,000 shares immediately eligible for sale upon issuance;

     -    30,000 shares on April 8, 2000;


                                       25
<PAGE>   28

     -    30,000 shares on July 8, 2000;

     -    30,000 shares on October 8, 2000;

     -    30,000 shares on January 8, 2001; and
     -    32,951 shares on April 8, 2001.
Dr. Fitzpatrick has also agreed that she may only exercise her warrants to
purchase 115,662 Nymox shares according to the following timetable:

     -    30,000 warrants, to be exercisable on or after January 8, 2001;

     -    30,000 warrants, to be exercisable on or after January 8, 2002;

     -    30,000 warrants, to be exercisable on or after January 8, 2003; and

     -    25,662 warrants, to be exercisable on or after January 8, 2004.

The warrants have a five-year term beginning on January 8, 2000.

Serex has issued convertible preferred shares, 10,137 to a major pharmaceutical
company and 10,137 to a major diagnostic company, under a series of licensing
and development agreements. The holders of these preferred shares have the right
to convert their preferred shares to common shares according to a formula set
out in Serex's amended articles of incorporation. At present, one preferred
share would convert to ten common shares. If converted to common stock, the
preferred shares would represent 14.5% of the outstanding common stock of Serex.

The preferred shareholders have a right to vote with the holders of the common
stock of Serex as if they had converted their preferred shares to common stock.

The preferred shareholders also have a right to redeem up to 50% of their shares
in certain circumstances after March 31, 2000 for a payment of $39.46 per
preferred share redeemed. Thus, if the full 50% of preferred shares were
redeemed, the redemption price would be $400,000.

The preferred shares also have preferential rights ahead of the common shares,
to any dividends and to the assets of the corporation on liquidation,
dissolution or winding up of the affairs of Serex. On merger or consolidation of
Serex, the preferred shareholders may, in certain circumstances, elect to treat
the merger or consolidation as a liquidation and to receive the redemption price
for their shares; otherwise the preferred shares would be converted into common
shares based on the conversion formula and treated like the other common shares.


                                       26



<PAGE>   29

SEREX, INC.

Serex is a privately held diagnostic company that was founded in 1983 and is
based in Maywood, New Jersey.

Serex developed and patented its particle valence technology, a unique, highly
sensitive, new method to detect very small amounts of biochemical indicators in
body fluids such as blood, urine and saliva. Serex incorporated this technology
in its LabTab(TM) assay, which enables the easy and rapid testing of samples by
general-purpose medical laboratories or in doctors' offices. Serex also licensed
the Japanese rights to two of its principal patents to Mizuho Medy Co. Ltd. of
Japan.

Serex's diagnostic technology can be adapted to detect a wide range of
biochemical indicators for diseases, conditions and drug use.

Serex developed its NicoMeter(TM) which can reliably detect one of the metabolic
products of nicotine in human urine and saliva, enabling it to determine the
level of exposure to tobacco products. The urine-based NicoMeter(TM) is
currently being manufactured under contract by Mizuho USA and marketed and sold
under a distribution agreement dated June 10, 1999 by Jant Pharmacal
Corporation.

Serex is developing Nymox's 7C Gold test, using its patented diagnostic
technology to detect in urine and spinal fluid the levels of the brain protein
implicated in Alzheimer's disease and measured by Nymox's AD7C(TM) test.

Serex has under development a test that can detect biochemical indicators of
cholesterol in human saliva and therefore provide an inexpensive, convenient and
reliable method of determining and monitoring cholesterol levels.
In November, 1999, Serex was granted a United States patent for an antibody and
for the use of the antibody in its technology in order to detect one of the
biochemical indicators for the loss of bone matter, which is a sign of
osteoporosis, the most common bone disease in people. Osteoporosis results from
the progressive loss of bone material and can cause disabling and potentially
life-threatening bone fractures in particular of the spine and the hips. It is
most common in the elderly and in post-menopausal women.
Serex has also used its patented technology to develop products to detect an
early indicator of pregnancy and to detect a brain protein implicated in certain
brain diseases.

Serex also did preliminary work on tests designed to detect indicators for heart
disease and for blood sugar levels in a type of diabetes and to monitor
therapeutic drug levels.

Since 1996, Serex has collaborated with at least three major pharmaceutical
companies and two diagnostic companies under licensing and development
agreements concerning the development of some of these products. These
agreements contain confidentiality provisions that prohibit the disclosure of
their terms.


                                       27






<PAGE>   30

EMPLOYMENT AGREEMENT WITH DR. JUDITH FITZPATRICK

Dr. Judith Fitzpatrick has also agreed to assume a position as Vice-President
for Scientific Affairs of Nymox and to continue on as Chief Executive Officer of
Serex.

Dr. Fitzpatrick, 53, received a Ph.D. in immunology from Mt. Sinai Medical
School (City College of NY) in 1981 and from 1981 to 1984 was employed by Becton
Dickinson as a Senior Scientist. She founded Serex in 1984 and has extensive
experience both in the scientific and commercial aspects of the development of
diagnostic tests. From 1984 to the early 1990s, she developed and supervised the
manufacture of laboratory tests for drugs and proteins of interest to the life
insurance industry. At one point, Serex was providing over six million tests per
year. In the early 1990s, Serex switched to a strip format technology to exploit
the emerging point-of-care markets. Dr. Fitzpatrick is a co-inventor of Serex's
patented diagnostic system.

The employment agreement between Nymox and Dr. Fitzpatrick has a term of four
years, renewing automatically at the end of the term on a year-to-year basis
subject termination by either party. Dr. Fitzpatrick's compensation is $125,000
a year and includes the grant of options to purchase 40,000 Nymox shares at
$3.70 per share under the Nymox Share Option Plan. The agreement provides that
these options shall vest as follows:

     -    10,000 on January 8, 2001;

     -    10,000 on January 8, 2002;

     -    10,000 on January 8, 2003; and

     -    10,000 on January 8, 2004.

The options expire on January 7, 2009.

The employment agreement envisages Dr. Fitzpatrick continuing with the
development of Nymox's 7C Gold test and Serex's diagnostic products as well as
participating in Nymox's research and development of treatments for Alzheimer's
disease, its anti-infectives program and other scientific projects.

                                 USE OF PROCEEDS

We will not realize any proceeds from the sale of the common shares by Jaspas;
rather, Jaspas will receive those proceeds directly. However, we will receive
cash infusions of capital if and when Jaspas purchases our common shares in
accordance with the stock purchase agreement with Jaspas or with the stock
purchase warrant. We intend to use the proceeds from the sale of common shares
to Jaspas to fund our continuing research, our product development programs and
necessary clinical trials, as well as for marketing, working capital and other
general corporate purposes.


                                       28



<PAGE>   31

                       THE COMMON STOCK PURCHASE AGREEMENT

SUMMARY
Nymox and Jaspas Investments Limited, a British Virgin Islands corporation,
signed a common stock purchase agreement dated November 1, 1999 for the future
issuance and purchase of Nymox's common shares. The transaction closed on
November 12, 1999. The stock purchase agreement establishes what is sometimes
termed an equity line of credit or an equity draw down facility.
In general, the draw down facility operates like this: the investor, Jaspas,
committed up to $12 million to purchase Nymox's common shares of Nymox over a
thirty month period. Once a month, Nymox may request a draw of up to $750,000 of
that money, subject to a formula based on average stock price and average
trading volume, setting the maximum amount of any request for any given draw. At
the end of a 22 day trading period following the draw down request, the amount
of money that Jaspas will provide to Nymox and the number of shares Nymox will
issue to Jaspas in return for that money is settled based on the formula in the
stock purchase agreement. Jaspas receives a six (6%) percent discount to the
market price for the 22 day period and Nymox receives the settled amount of the
draw down less a 3% placement fee payable to the placement agent, Ladenburg
Thalmann & Co. Inc., which introduced Jaspas to Nymox. Ladenburg Thalmann is not
obligated to purchase any Nymox shares.

The facility is based on a "use-it-or-lose" principle. We are under no
obligation to request a draw for any month. However if we do not request a draw
for a given month, we may never to be able to draw those funds again. We may
make up to a maximum of twenty-four (24) draws; however, the aggregate total of
all draws cannot exceed $12 million.

In lieu of providing Jaspas with a minimum draw down commitment, we agreed to
issue to Jaspas a stock purchase warrant to purchase up to 200,000 shares of our
common stock with an exercise price of 110% of our share price on the closing
date of November 12, 1999 or $4.53. Jaspas may purchase under the warrant up to
100,000 Nymox shares any time between November 30, 1999 and November 30, 2004.
Jaspas may purchase the remaining 100,000 shares if and only if we do not draw
down at least $7 million within 18 months of _____________, 2000.

THE DRAW DOWN PROCEDURE AND THE STOCK PURCHASES

We may make up to twenty-four draw downs during the term of the stock purchase
agreement.

We may request a draw down by faxing a draw down notice to Jaspas, setting out
the amount of the draw down we wish to exercise and the minimum threshold price,
if any, at which we are willing to sell the shares.

The minimum draw down amount is $150,000. The maximum is $750,000 subject to the
following limiting formulas:


                                       29



<PAGE>   32

- - For draw downs greater than $500,000 and up to $500,000

<TABLE>
<S>                               <C>
Maximum amount of draw down        = 20% of average stock price multiplied by average trading volume multiplied
                                     by 22

where

Average Stock Price                = Average of the daily price of Nymox's shares for the 22 trading days PRIOR to
                                     the draw down period

Average Trading Volume             = Average daily trading volume for the 45 trading days PRIOR to the draw down
                                     period.
</TABLE>

- - For draw downs greater than $500,000 and up to $750,000

If, during the 30 Trading Days prior to the draw down notice, the average daily
trading volume is at least 60,000 shares and the average of the average daily
price is at least $4.50 per share, then we may draw up to $750,000.

The next 22 trading days immediately following the draw down notice are used to
determine the actual amount of money Jaspas will provide and the number of
shares Nymox will issue in return. The 23rd trading day is the draw down
exercise date when the amount of the draw and the number of shares to be issued
is calculated based on the following formula:

<TABLE>
<S>                                      <C>
number of common shares                   = Sum over each of
                                            the 22 trading days of 1/22 of the
                                            draw down amount divided by 94% of
                                            the daily price for Nymox shares on
                                            each trading day.
</TABLE>

If the daily price for any given trading day during the draw down period is
below the threshold price set by Nymox in the draw down notice, then that day is
not included in the calculation of the number of shares to be issued and the
draw down amount that Jaspas is to pay to Nymox is correspondingly reduced by
1/22 for that day. Thus, if the daily price for that day is below the threshold
price Nymox will not issue any shares and Jaspas will not purchase any shares
for that day.

The following is an example of the calculation of the draw down amount and the
number of shares to be issued to Jaspas in connection with that draw down based
on certain assumptions.


                                       30



<PAGE>   33

Sample draw down amount calculation.

     -    Nymox provides a draw down notice to Jaspas that it wishes to draw
          down $400,000.

     -    The average of daily volume weighted average price of Nymox's common
          shares for 22 trading days prior to the draw down notice is $3.50.

     -    The average daily trading volume for the 45 trading days prior to the
          draw down notice is 25,000 shares.

     -    The maximum dollar amount that can be drawn down is:

          20% of $3.50 multiplied by 25,000 multiplied by 22 or $385,000.

On these assumed facts, Nymox could draw $385,000 out of the $400,000 requested
in the draw down notice.

Sample calculation of number of shares

Assume that the maximum draw down amount for the draw down period is $385,000
and assume that the daily volume weighted average price for Nymox's shares is as
set out in the table below. The number of shares to be issued based on any
trading day during the draw down period is calculated from the formula:

     (1/22 of the draw down amount) divided by (94% of the daily price).

For the first trading day in the example in the table below, the calculation is
as follows:

     (1/22 of $385,000) divided by (94% of $3.50 per share) or 5,319 shares.

The number of shares to be issued for the draw down period in the example is
calculated as follows:

     -    for each trading day in the 22 day period, the number of shares to be
          issued is based on the daily price of Nymox's shares for that day and
          calculated using the formula above; and

     -    the number of shares to be issued for each of the 22 trading days is
          then totaled to arrive at the number of shares to be issued to Jaspas
          at the end of the draw down period for the purchase price of $385,000,
          the draw down amount.


                                       31



<PAGE>   34

<TABLE>
<CAPTION>
- ------------------------ -------------------------- ------------------------- ----------------------------------
                                                    1/22 of Draw Down         Number of Shares to be issued
      Trading Day        Daily Stock Price          Amount of $385,000        based on that trading day.
- ------------------------ -------------------------- ------------------------- ----------------------------------
      <S>                        <C>                      <C>                             <C>
           1                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
           2                      $3.625                    $17,500                         5,136
- ------------------------ -------------------------- ------------------------- ----------------------------------
           3                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
           4                      $3.375                    $17,500                         5,516
- ------------------------ -------------------------- ------------------------- ----------------------------------
           5                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
           6                       $3.75                    $17,500                         4,965
- ------------------------ -------------------------- ------------------------- ----------------------------------
           7                      $3.875                    $17,500                         4,804
- ------------------------ -------------------------- ------------------------- ----------------------------------
           8                       $4.00                    $17,500                         4,654
- ------------------------ -------------------------- ------------------------- ----------------------------------
           9                       $4.25                    $17,500                         4,380
- ------------------------ -------------------------- ------------------------- ----------------------------------
          10                       $3.75                    $17,500                         4,965
- ------------------------ -------------------------- ------------------------- ----------------------------------
          11                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
          12                       $3.25                    $17,500                         5,728
- ------------------------ -------------------------- ------------------------- ----------------------------------
          13                       $3.00                    $17,500                         6,206
- ------------------------ -------------------------- ------------------------- ----------------------------------
          14                       $3.25                    $17,500                         5,728
- ------------------------ -------------------------- ------------------------- ----------------------------------
          15                      $3.375                    $17,500                         5,516
- ------------------------ -------------------------- ------------------------- ----------------------------------
          16                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
          17                      $3.625                    $17,500                         5,136
- ------------------------ -------------------------- ------------------------- ----------------------------------
          18                       $3.75                    $17,500                         4,965
- ------------------------ -------------------------- ------------------------- ----------------------------------
          19                      $3.875                    $17,500                         4,804
- ------------------------ -------------------------- ------------------------- ----------------------------------
          20                       $4.00                    $17,500                         4,654
- ------------------------ -------------------------- ------------------------- ----------------------------------
          21                       $3.75                    $17,500                         4,965
- ------------------------ -------------------------- ------------------------- ----------------------------------
          22                       $3.50                    $17,500                         5,319
- ------------------------ -------------------------- ------------------------- ----------------------------------
         TOTAL                                              $385,000          114,037 shares to be issued for
                                                                              the draw down period
- ------------------------ -------------------------- ------------------------- ----------------------------------
</TABLE>

In this fictitious example, Nymox would issue 114,037 shares for this draw down
period. It would receive $385,000 less the 3% fee to the placement agent or
$373,450.
The delivery of the requisite number of shares and payment of the draw is
effected through an escrow agent, Epstein, Becker & Green, P.C. of New York. The
escrow agent pays 97% of the draw to Nymox and 3% to Ladenburg Thalmann & Co.
Inc., our placement agent, in satisfaction of placement agent fees.

Only one draw down can occur during this 22 day draw down period and Nymox must
wait a minimum of five trading days from the end of one draw down period before
issuing the next draw down notice and beginning the process again.

                                       32



<PAGE>   35

NECESSARY CONDITIONS BEFORE JASPAS IS OBLIGED TO PURCHASE NYMOX'S SHARES.

The following conditions must be satisfied before Jaspas is obligated to
purchase the common shares that Nymox wishes to sell:

     -    A registration statement for the shares Nymox will be issuing must be
          declared effective by the Securities and Exchange Commission and must
          remain effective and available as of the draw down settlement date for
          making resales of the common shares purchased by Jaspas.

     -    There can be no material adverse change in Nymox's business,
          operations, properties, prospects or financial condition not publicly
          reported since the most recent prior draw down exercise date.

     -    No statute, rule, regulation, executive order, decree, ruling or
          injunction may be in effect which prohibits consummation of the
          transactions contemplated by the stock purchase agreement.

     -    No litigation or proceeding adverse to Nymox, Jaspas or their
          affiliates, can be pending, nor any investigation by any governmental
          authority threatened against them seeking to restrain, prevent or
          change the transactions contemplated by the stock purchase agreement
          or seeking damages in connection with such transactions.

     -    Trading in Nymox's common shares must not have been suspended by the
          Securities and Exchange Commission or the Nasdaq SmallCap Market, nor
          shall minimum prices have been established on securities whose trades
          are reported by the Nasdaq SmallCap Market.

On each draw down settlement date for the sale of common shares, Nymox must
deliver an opinion from its counsel about these matters.

A further condition is that Jaspas may not purchase more than 19.9% of Nymox's
common shares issued and outstanding on November 12, 1999, the closing date
under the stock purchase agreement, without obtaining approval from Nymox
shareholders for such excess issuance.

RESTRICTIONS ON FUTURE FINANCINGS FOR NYMOX.

The stock purchase agreement limits Nymox's ability to raise money by selling
its securities for cash at a discount to the current market price for at least
eighteen months. Specifically, Nymox may not sell its securities for cash at a
discount to current market price until the earlier of

     -    eighteen months from ___________________, 2000, the effective date of
          the registration statement of which this prospectus is a part, or, if
          later, the date that Nymox has drawn down at least $8,000,000 or

     -    sixty days after Jaspas has purchased the maximum $12 million of
          common shares from Nymox.


                                       33
<PAGE>   36

There are important exceptions to this limitation. Nymox can sell its shares for
cash at a discount to the current market price:

     -    in a registered public offering of its securities underwritten by one
          or more established investment banks;

     -    in one or more private placements where the purchasers do not have
          registration rights;

     -    under any employee benefit plan approved by the shareholders of Nymox;

     -    under any compensatory plan for a full-time employee or key
          consultant;

     -    in connection with a strategic partnership or other business
          transaction, the principal purpose of which is not simply to raise
          money; or

     -    for which Jaspas has given its written approval.

THE WARRANTS ISSUED TO JASPAS

Under the stock purchase agreement, we granted Jaspas a warrant to purchase
200,000 shares of Nymox's common shares, exercisable for a period of five (5)
years from November 30, 1999, at an exercise price equal to 110% of the average
daily price of the common shares on the closing date of November 12, 1999. The
average daily price of Nymox's shares for that day was $4.1097; thus the
exercise price for the warrant is $4.53.

The warrant permits Jaspas to purchase up to 100,000 shares at any time after
November 30, 1999 and before the close of business on November 30, 2004.

Jaspas may purchase the remaining 100,000 shares in the warrant if and only if
Nymox has not draw down at least $7,000,000 within eighteen months from the
effective date of the registration statement.

COSTS OF CLOSING THE TRANSACTION.

At the closing of the transaction on November 12, 1999, we delivered the warrant
for the 200,000 common shares and the requisite opinion of counsel to Jaspas and
paid the escrow agent, Epstein Becker & Green P.C. $35,000 for Jaspas's legal,
administrative and escrow costs and for the ordinary services of the escrow
agent for each closing of a draw down. We also paid a placement fee of $100,000
to Ladenburg Thalmann & Co. Inc. and an additional $35,000 for its expenses.
Ladenburg Thalmann & Co. Inc. will also receive warrants for a total of 160,000
common shares of Nymox with a strike price of 100% of the closing bid for Nymox
shares on November 12, 1999 or $4 1/16. Ladenburg Thalmann is not obligated to
purchase any Nymox shares.


                                       34
<PAGE>   37

TERMINATION OF THE STOCK PURCHASE AGREEMENT

Jaspas may terminate the equity draw down facility under the stock purchase
agreement if any of the following events occur:

     -    Nymox suffers a material adverse change in its business operations,
          properties, prospects or financial condition;

     -    the common shares of Nymox are delisted from the Nasdaq SmallCap
          Market unless such is in connection with the listing of such shares on
          a comparable stock exchange in the United States;

     -    Nymox files for protection from creditors, or;

     -    Nymox completes any of the financing transactions prohibited under the
          stock purchase agreement.

INDEMNIFICATION OF JASPAS.

Jaspas is entitled to customary indemnification from Nymox for any losses or
liabilities suffered by it based upon material misstatements or omissions from
the registration statement and the prospectus, except as they relate to
information supplied by Jaspas to Nymox for inclusion in such registration
statement and prospectus.

JASPAS'S RESALE OF THE COMMON SHARES

Jaspas has agreed that its trading and distribution activities with respect to
the common shares will be in compliance with all applicable United States state
and federal securities laws, rules and regulations; all Canadian securities
laws, rules and regulations; and the rules and regulations of the Nasdaq
SmallCap Market. Jaspas has further acknowledged that the common shares may not
be traded in a Canadian province until the expiration of the period during which
a purchaser resident in such province, purchasing under similar circumstances,
would be required to hold the common shares, except as otherwise permitted by
the laws, rules and regulations of such province. All sales by Jaspas must be
made in compliance with Regulation M under the Securities and Exchange Act of
1934.

To permit Jaspas to resell the common shares issued to it under the stock
purchase agreement or under the warrant, Nymox agreed to register those shares
and to maintain that registration. To that end, Nymox will prepare and file such
amendments and supplements to the registration statement and the prospectus as
may be necessary in accordance with the Securities Act and the rules and
regulations promulgated thereunder, in order to keep it effective until the
earlier of any of the following dates:


                                       35
<PAGE>   38

     -    the date that none of the common shares covered by the registration
          statement of which this prospectus is a part are or may become issued
          and outstanding;

     -    the date that all of the common shares covered by the registration
          statement of which this prospectus is a part have been sold pursuant
          to such registration statement;

     -    the date the holders of the common shares receive an opinion of
          counsel to Nymox, such counsel to be reasonably acceptable to Jaspas,
          that such common shares may be sold under the provisions of Rule 144
          under the Securities Act of 1933 without limitation as to volume;

     -    the date that all of the common shares have been otherwise transferred
          to persons who may trade such shares without restriction under the
          Securities Act of 1933 and Nymox has delivered new certificates or
          other evidences of ownership of such common shares without any
          restrictive legend; or

     -    the date that all of such common shares may be sold without any time,
          volume or manner limitations under Rule 144(k) or similar provision
          then in effect under the Securities Act of 1933 in the opinion of
          counsel to Nymox, such counsel to be reasonably acceptable to Jaspas.

THE NUMBER OF SHARES NYMOX WILL ISSUE TO JASPAS.

The number of common shares that Nymox will issue to Jaspas depends on four key
factors:

     -    the number of draw downs Nymox exercises;

     -    the average trading volumes for its stock for the 45 trading days
          prior to each draw down period;

     -    the average stock price for its stock for the 22 trading days prior to
          each draw down periods; and

     -    the average daily prices for its stock on each of the 22 days during a
          draw down period.

The fewer the number of draw down Nymox exercises, the fewer the shares we will
issue to Jaspas. The stock purchase agreement provides for 24 draw downs in a 30
month period with each draw down period consisting of 22 trading days with at
least 5 trading days between each draw down period. Thus, any decision by Nymox
to delay or forego any draw down opportunity may result in Nymox's being unable
to exercise all 24 draw downs available in the 30 month period.

The average stock price and the average trading volume prior to a draw down
period determine the maximum amount of the draw down for that period. A decline
in the trading volume or price of our stock may result in a reduction in the
amount of money Nymox is able to draw down and a corresponding reduction in the
number of shares Nymox must issue for that period.


                                       36
<PAGE>   39

The average daily price for each of the 22 trading days within a draw period and
the draw down amount determine the number of shares Nymox will issue to Jaspas
at the end of that period. Jaspas will purchase those shares at a 6% discount to
the average daily price.

For any given draw period, the lower the average daily price, the more common
shares Jaspas will receive for the draw down amount. The table in the section of
this prospectus entitled "The Common Stock Purchase Agreement" and under the
headings "The Draw Down Procedure and the Stock Purchases" and "Sample
Calculation of Number of Shares" illustrates how a change in the daily stock
price can affect the number of shares issued for a constant amount of draw down.
This table uses a constant draw down amount of $17,500 for each day. When the
stock price goes down, the number of shares issued goes up. Conversely, when the
stock price goes up, the number of shares issued goes down.

However, lower average daily prices through the term of the stock purchase
agreement may not necessarily have the effect of substantially increasing the
number of shares issued. Lower stock prices during one draw period will reduce
the average stock price for the next draw down period. Assuming relatively
constant trading volumes, this reduction may limit the draw down amount and the
number of shares Nymox can issue for that next period.

Based on a review of its trading volume and stock price history and a
consideration of the factors above, Nymox is registering 4,800,000 common shares
for possible issuance under the stock purchase agreement and 200,000 shares
underlying the warrant for common shares already delivered to Jaspas.

In order to comply with the listing requirements of the Nasdaq SmallCap Market,
Nymox may not issue more than 3,980,757 shares, which is 19.9% of the issued and
outstanding common shares of Nymox on November 12, 1999, the date of the closing
of the stock purchase agreement, without the approval of its shareholders. In
the event that Nymox wishes to draw amounts under the stock purchase agreement
which would cause an issuance of more than 19.9% of its issued and outstanding
shares, Nymox must receive shareholder approval prior to any such draw down.

                             SELLING SECURITY HOLDER

Jaspas is engaged in the business of investing in publicly-traded equity
securities for its own account. Jaspas's principal offices are located at
Aeulestrasse 74, Vaduz, Liechtenstein. Investment decisions for Jaspas are made
by its Board of Directors, consisting of Mr. Hans Gassner, Dr. Kurt Alig and Dr.
Alex Weiderkehr.

Jaspas does not own any common shares of Nymox or any other securities of Nymox
as of the date of this prospectus, and other than its obligations to purchase
common shares under the stock purchase agreement and the warrant for 200,000
shares issued to it on November 12, 1999, it has no other commitments or
arrangements to purchase or sell any securities of Nymox.


                                       37
<PAGE>   40

There are no business relationships between Jaspas and Nymox other than the
stock purchase agreement.

Common shares registered for resale under this prospectus constitute 25% of the
issued and outstanding Nymox common shares on November 12, 1999.

Assuming that Nymox fully utilizes the $12 million available in the stock
purchase agreement and that Jaspas sells all shares it acquired under that
agreement or upon exercise of the warrant, Jaspas will no longer hold any common
shares of Nymox.

                         DIRECTORS AND OFFICERS OF NYMOX

The directors and executive officers of Nymox Pharmaceutical Corporation are:

Senator W. David Angus, QC, 62, Chairman and Director since May 13, 1999, is a
member of the Senate of Canada, serving on the Standing Committee on Banking,
Trade and Commerce. He is also a senior partner at the Montreal office of
Stikeman, Elliott, Canada's global law firm, and a director of several other
Canadian corporations and charitable organizations, including Air Canada, AON
Reed Stenhouse, Eastern Canada Towing Ltd. and the McGill University Health
Center.

Dr. Paul Averback, M.D., D.A.B.P., 49, President and Director since September
1995, is the founder of Nymox and the inventor of much of its initial
technology. Prior to founding Nymox, Dr. Averback served as President of Nymox's
predecessor, DMS Pharmaceuticals Inc. He received his M.D. in 1975 and taught
pathology at universities, including Cambridge University, England (1977-1980),
during which time he initiated his research on Alzheimer's disease. He has
practiced medicine in numerous Canadian institutions as well as in private
practice. Dr. Averback has published extensively in the scientific and medical
literature.

Dr. Colin B. Bier, Ph.D., 54, Director since December 1995, is a leading
authority on toxicology and pharmaceutical and biotechnological regulatory
affairs and has extensive management experience in the biomedical sector. Dr.
Bier was formerly Vice-President and Director of Toxicology at Bio-Research
Laboratories, President and Chief Executive Officer of ITR Laboratories and has
consulted, managed and been affiliated with numerous biochemical enterprises.

Dr. J. Kenneth Harrington, Ph.D., 63, Director since January 1996, has over 30
years of experience with 3M's Life Sciences businesses, including the positions
of Vice-President of Riker Pharmaceuticals and Group Director of 3M's European
pharmaceutical divisions. Dr. Harrington is a named inventor on 42 US patents,
and has been involved in over 100 successful FDA filings.


                                       38
<PAGE>   41

Dr. Hans Black, MD, 46, Director since May 13, 1999, has a doctorate in medicine
from McGill University, and is Chairman and Chief Investment Officer of
Interinvest Consulting Corporation, a Montreal-based global money management
firm with offices in Toronto and Boston and affiliates in Bermuda and Zurich.
Dr. Black appears regularly on the PBS network show, Nightly Business Report,
and has been a guest lecturer at Harvard, Temple and McGill Universities.

Martin Barnes, 49, Director since June 1997, is Managing Editor of The Bank
Credit Analyst. Prior to joining The Bank Credit Analyst Research Group in 1987,
Mr. Barnes was the Chief economist at Wood Mackenzie, a leading Edinburgh
brokerage firm (1977-1987) and an economist at British Petroleum in London
(1973-1977).

Mr. Roy M. Wolvin, 45, Secretary-Treasurer and Chief Financial Officer since
September 1995. Prior to September 1995, Mr. Wolvin was Account Manager, private
business, for a Canadian chartered bank. Mr. Wolvin holds a degree in Economics
from the University of Western Ontario.

Directors are elected at each annual meeting for a term of office until the next
annual meeting. Executive officers are appointed by the board of directors and
serve at the pleasure of the board. Other than Dr. Averback, no other officer or
director previously was affiliated with DMS Pharmaceuticals Inc.

There are no family relationships between any director or executive officer and
any other director or executive officer.

                                  COMPENSATION

The table below provides compensation information for the fiscal year ended
December 31, 1999 for each executive officer of Nymox and for the directors and
executive officers as a group.

Summary Compensation Table
(expressed in Canadian dollars)

<TABLE>
<CAPTION>
                                             Fiscal Year ending                 Fiscal Year ending
                                                Dec. 31, 1998                     Dec. 31, 1999

Name and Principal Position                          Other Cash                        Other Cash
                                      Salary        Compensation        Salary        Compensation
                                      ------        ------------        ------        ------------
<S>                                     <C>             <C>              <C>             <C>
Dr. Paul Averback,
President and Director                  $150,000         -               $150,000          -

Mr. Roy Wolvin,
Secretary-Treasurer                     $ 70,200         -               $ 70,200          -

All directors and executive
officers as a group                     $220,200         -               $220,200          -
</TABLE>


                                       39
<PAGE>   42

See "Options" below for information about stock options granted to directors,
executive officers and other employees.

Nymox does not have written employment contracts with any of the executive
officers named above.

Directors of Nymox, with the exception of the President, are paid a fee of
CAN$1,000 for each board meeting attendance and are reimbursed for expenses
incurred in connection with their office.

Nymox does not have any pension plans or other type of plans providing
retirement or similar benefits for directors or executive officers.

                                     OPTIONS

Options and Warrants

<TABLE>
<CAPTION>
Total amount of common shares
subject to exercisable options                 Purchase price         Expiration Date
- ------------------------------                 --------------         ---------------

        <S>                                     <C>                   <C>
         100,000                                CAN$ 7.00             November 9, 2002

         275,000                                CAN$ 3.25             January 17, 2006

          20,000                                CAN$13.75             January 17, 2006

          20,000                                CAN$ 9.80             January 17, 2006

          20,000                                CAN$10.00             January 17, 2006

         100,000                                CAN$11.50               April 30, 2006

          10,000                                CAN$16.75              August 13, 2006

          10,000                                CAN$ 9.00              August 13, 2006

          20,000                                CAN$10.00              August 13, 2006

          25,000                                CAN$ 9.00             October 31, 2007

          60,000                                CAN$10.00             October 31, 2007

           6,000                                CAN$ 9.25            December 19, 2007

          50,000                                CAN$10.00             January 22, 2009

         150,000                                CAN$ 4.50                 May 13, 2009

          37,500                                CAN$ 4.50                 June 1, 2009

        Warrants
        --------

         200,000                                 $ 4.5315            November 30, 2004

         160,000                                  $4.0625            November 12, 2009
</TABLE>


                                       40
<PAGE>   43

The total number of shares subject to options at December 31, 1999 is 1,130,500,
of which options representing 891,000 are currently exercisable. Of those, the
total number of shares subject to options held by directors and officers of
Nymox is 325,000 of which options representing 215,000 shares are currently
exercisable.

There are no rights, warrants or options presently outstanding under which Nymox
could issue additional common shares, with the exception of options enabling
certain directors, employees and consultants of Nymox to acquire common shares
under Nymox's stock option plan and of warrants entitling the holders to acquire
up to 360,000 common shares of Nymox as outlined in the above table.

Nymox has created a stock option plan for its key employees, its officers and
directors and certain consultants. The board of directors of Nymox administers
the plan. The board may grant options to purchase a specified number of common
shares of Nymox to a designated individual. The total number of common shares to
be optioned to any one individual cannot exceed 5% of the total number of issued
and outstanding shares and the maximum number of common shares which may be
optioned under the plan cannot exceed 2,500,000 shares without shareholder
approval.

The board fixes the option price per share for common shares that are the
subject of any option, when it grants any such option. The option price cannot
involve a discount to the market price when the option is granted. The period
during which an option is exercisable shall not exceed 10 years from the date
when the option is granted. The options may not be assigned, transferred or
pledged and expire within three months of the termination of employment and six
months of the death of an individual.

On January 17, 1996, the board of directors granted options to purchase up to
400,000 common shares for a period of 10 years. Of these, options to purchase
120,000 common shares were granted to directors and officers of Nymox and
options to purchase 280,000 shares were granted to consultants of Nymox.
Specifically the board granted:

     -    options to purchase 310,000 common shares of Nymox at a price of
          CAN$3.25 per share for a period of ten years to a total of seven
          beneficiaries, of which options a total of 35,000 common shares have
          been exercised to date;

     -    options to two directors of Nymox to acquire 5,000 common shares of
          Nymox, effective as of each of the first five anniversary dates of
          January 17, 1996 for a total of 25,000 shares each, provided they
          still be associated with the Company as of the vesting dates. The
          vesting schedule and prices per block of shares are as follows:


                                       41
<PAGE>   44

               January 17,1997 - 5,000 shares - CAN$13.75 per share
               January 17,1998 - 5,000 shares - CAN$ 9.80 per share
               January 17,1999 - 5,000 shares - CAN$10.00 per share
               January 17,2000 - 5,000 shares - CAN$10.00 per share
               January 17,2001 - 5,000 shares - CAN$10.00 per share; and

     -    options to one senior executive of Nymox additional to acquire 10,000
          common shares of Nymox, effective as of each of the first four
          anniversary dates of January 17, 1996 for a total of 40,000 additional
          shares, provided he still be associated with the Company as of the
          vesting dates. The vesting schedule and prices per block of shares are
          as follows:

               January 17,1997 - 10,000 shares - CAN$13.75 per share
               January 17,1998 - 10,000 shares - CAN$ 9.80 per share
               January 17,1999 - 10,000 shares - CAN$10.00 per share
               January 17,2000 - 10,000 shares - CAN$10.00 per share.

Under the same plan, on April 30, 1996, the board granted options to purchase
100,000 common shares of Nymox at a price of CAN$11.50 per share for a period of
ten years to three beneficiaries.

On August 13, 1996, the board granted one consultant of Nymox options to acquire
10,000 common shares of the Company at a price of CAN$16.75 for a period of ten
years. This consultant was granted additional options to acquire 10,000 common
shares of Nymox, effective as of each of the first four anniversary dates of
August 13, 1996 for a total of 40,000 additional shares, provided he is still be
associated with Nymox as of the vesting dates. The vesting schedule and prices
per block of shares are as follows:

               August 13,1997 - 10,000 shares - CAN$ 9.00 per share
               August 13,1998 - 10,000 shares - CAN$10.00 per share
               August 13,1999 - 10,000 shares - CAN$10.00 per share
               August 13,2000 - 10,000 shares - CAN$10.00 per share.

Under the same plan, on October 31, 1997, the board granted options to purchase
up to 155,000 common shares to four beneficiaries. Specifically the board
granted:

     -    options to purchase 25,000 common shares of the Company at a price of
          CAN$9.00 per share for a period of 10 years to five beneficiaries;

     -    options to two directors of the Company options to acquire 5,000
          common shares of Nymox, effective as of each of the first five
          anniversary dates of October 31, 1997, at a price of CAN$10.00 per
          share for a total of 25,000 additional shares each, provided they
          still be associated with Nymox as of the vesting dates; and


                                       42
<PAGE>   45

     -    options to a director and an executive of Nymox to acquire 10,000
          common shares of Nymox, effective as of each of the first four
          anniversary dates of October 31, 1997, at a price of CAN$10.00 per
          share for a total of 40,000 additional shares each, provided they
          still be associated with Nymox as of the vesting dates.

On December 19, 1997 and on May 13, 1999, the board granted options to purchase
up to 15,500 common shares under Nymox's stock option plan to certain key
employees of Nymox at a price of CAN$9.25 per share for a period of ten years,
provided they still be associated with Nymox as of the vesting dates. All
options granted to these employees vest over a period of three years from the
date when the board granted them. Of these options, 6,000 are currently vested.

On November 9, 1998, the board granted one consultant of Nymox options to
acquire 100,000 common shares of the Company at a price of CAN$7.00 per share,
such options to be exercisable for a period of four years from November 9, 1998.

On January 22, 1999, the board granted one executive of Nymox options to acquire
50,000 common shares of Nymox at a price of $10.00 per share, such options to be
exercisable for a period of 10 years from January 22, 1999.

On May 13, 1999, the board granted options to purchase up to 150,000 common
shares under Nymox's stock option plan for a period of ten years at a price of
CAN$4.50 per share to seven beneficiaries. It also granted a director of Nymox
additional options to acquire 40,000 shares at a price of CAN$10.00 per shares,
vesting 10,000 shares per year, starting on May 13, 2000 and continuing to May
13, 2004, provided the director still be associated with Nymox as of the vesting
dates.

On May 13, 1999, the board granted one consultant of the Company options to
acquire 100,000 common shares of the Company at a price of CAN$4.50 per share,
such options to be exercisable for a period of 10 years from June 1, 1999.
These options are subject to vesting at the rate of 12,500 per quarter
commencing June 1, 1999 to March 1, 2001.

To date, a total of 1,083,100 options granted to former employees and
consultants to purchase common shares of the Company have expired and 108,900
were exercised prior to the expiry date. In addition, 30,000 options granted to
consultants have been canceled.

                 INTEREST OF MANAGEMENT IN CERTAIN TRANSACTIONS

A former director and senior officer of Nymox, Hossein Ghanbari, while still
with Nymox, received a loan of CAN$56,000 for the purchase of a home following
his move from the United States to Canada to assume his duties with Nymox. This
loan was interest free and had no fixed terms of repayment. He subsequently used
additional funds of $125,000 to assist in the purchase of a home following his
return to the United States from Canada to work for Nymox's United States
subsidiary, Nymox Corporation. He repaid $5,000 of the $125,000 while still with
Nymox Corporation. On January 22, 1999, he gave Nymox Corporation two promissory
notes for these debts, payable on demand. The promissory note for the loan for
CAN$56,000 was interest-free; the promissory note for the outstanding sum of
$120,000 bore interest at the rate of 9% per annum.


                                       43
<PAGE>   46

Hossein Ghanbari is no longer with Nymox and Nymox Corporation has since
obtained partial summary judgment on these promissory notes in the amount of
$168,731.83. See - Information About the Company - Certain Legal Proceedings.

                             CONTROLLING SHAREHOLDER

The following table sets out as of December 31,1999 the number of common shares
owned by Dr. Paul Averback, the President and CEO of Nymox and a member of the
Nymox board of directors, and by all directors and officers as a group. Dr.
Averback is the only person known to Nymox to own more than 10% of the common
shares.

<TABLE>
<CAPTION>
                                             Number of Common Shares               Percent of Class of
Name of Shareholder                           owned by Shareholder                    Common Shares
- -------------------                          -----------------------               -------------------

<S>                                                 <C>                                   <C>
Dr. Paul Averback                                   12,643,895                            63.2%

All directors and officers as a group               12,685,895                            63.2%
</TABLE>

In addition, as of December 31, 1999, Dr. Averback's wife owned 1,154,297 common
shares (5.8%) and 9022-1433 Canada Inc., a company owned by Dr. Averback and his
wife, owns 500,000 common shares (2.5%).

Nymox does not know of any other shareholder who beneficially owns more than 10%
of Nymox's shares.

                              PLAN OF DISTRIBUTION

GENERAL

Jaspas is offering the common shares for its account as statutory underwriter,
and not for the account of Nymox. Nymox will not receive any proceeds from the
sale of common shares by Jaspas.

Jaspas may be offering for sale up to 5,000,000 common shares acquired by it
either upon exercise of the warrant for common shares or pursuant to the terms
of the stock purchase agreement more fully described under the section above
entitled "The Common Stock Purchase Agreement."


                                       44
<PAGE>   47

Jaspas has agreed to be named as a statutory underwriter within the meaning of
the Securities Act of 1933 in connection with such sales of common shares and
will be acting as an underwriter in its resales of the common shares under this
prospectus.

Jaspas has, prior to any sales, agreed not to effect any offers or sales of the
common shares in any manner other than as specified in the prospectus and not to
purchase or induce others to purchase common shares in violation of Regulation M
under the Exchange Act.

The common shares may be sold from time to time by Jaspas or by pledgees,
donees, transferees or other successors in interest. Such sales may be made on
the Nasdaq SmallCap Market, on the over-the-counter market or otherwise at
prices and at terms then prevailing or at prices related to the then current
market price, or in negotiated private transactions, or in a combination of
these methods.

The common shares may be sold in one or more of the following manners:

     -    a block trade in which the broker or dealer so engaged will attempt to
          sell the shares as agent, but may position and resell a portion of the
          block as principal to facilitate the transaction;

     -    purchases by a broker or dealer for its account under this prospectus;
          or

     -    ordinary brokerage transactions and transactions in which the broker
          solicits purchases.

In effecting sales, brokers or dealers engaged by Jaspas may arrange for other
brokers or dealers to participate. Except as disclosed in a supplement to this
prospectus, no broker-dealer will be paid more than a customary brokerage
commission in connection with any sale of the common shares by Jaspas. Brokers
or dealers may receive commissions, discounts or other concessions from Jaspas
in amounts to be negotiated immediately prior to the sale. The compensation to a
particular broker-dealer may be in excess of customary commissions. Profits on
any resale of the common shares as a principal by such broker-dealers and any
commissions received by such broker-dealers may be deemed to be underwriting
discounts and commissions under the Securities Act of 1933. Any broker-dealer
participating in such transactions as agent may receive commissions from Jaspas
(and, if they act as agent for the purchaser of such common shares, from such
purchaser). Broker-dealers may agree with Jaspas to sell a specified number of
common shares at a stipulated price per share, and, to the extent such a broker
dealer is unable to do so acting as agent for Jaspas, to purchase as principal
any unsold common shares at price required to fulfill the broker-dealer
commitment to Jaspas. Broker-dealers who acquire common shares as principal may
thereafter resell such common shares from time to time in transactions (which
may involve crosses and block transactions and which may involve sales to and
through other broker-dealers, including transactions of the nature described
above) in the over-the-counter market, in negotiated transactions or otherwise
at market prices prevailing at the time of sale or at negotiated prices, and in
connection with such resales may pay to or receive from the purchasers of such
common shares commissions computed as described above. Such brokers or dealers
and any other participating brokers or dealers may be deemed to be underwriters
in connection with such sales.


                                       45
<PAGE>   48

In addition, any common shares covered by this prospectus which qualify for sale
pursuant to Rule 144 may be sold under Rule 144 rather than pursuant to this
prospectus.

Nymox will not receive any of the proceeds from the sale of these common shares,
although it has paid the expenses of preparing this prospectus and the related
registration statement of which it is a part, and has reimbursed Jaspas $35,000
for its legal, administrative and escrow costs.

Jaspas is subject to the applicable provisions of the Exchange Act, including
without limitation, Rules 10b-5 and Regulation M thereunder. Under applicable
rules and regulations under the Exchange Act, any person engaged in a
distribution of the common shares may not simultaneously engage in market making
activities with respect to such securities for a period beginning when such
person becomes a distribution participant and ending upon such person's
completion of participation in a distribution, including stabilization
activities in the common shares to effect covering transactions, to impose
penalty bids or to effect passive market making bids.

In addition, in connection with the transactions in the common shares, Nymox and
Jaspas will be subject to applicable provisions of the Exchange Act and the
rules and regulations under that Act, including, without limitation, the Rules
set forth above, and in so far as Nymox and Jaspas are distribution
participants, Regulation M. These restrictions may affect the marketability of
the common shares. Jaspas will pay all commissions and certain other expenses
associated with the sale of the common shares.

Nymox will use its best efforts to file, during any period in which offers or
sales are being made, one or more post effective amendments to the registration
statement of which this prospectus is a part to describe any material
information with respect to the plan of distribution not previously disclosed in
this prospectus or any material change to such information in this prospectus.
This obligation may include, to the extent required under the Securities Act of
1933, that a supplemental prospectus be filed, disclosing

     -    the name of any such broker-dealers;

     -    the number of common shares involved;

     -    the price at which the common shares are to be sold;

     -    the commissions paid or discounts or concessions allowed to such
          broker-dealers, where applicable;


                                       46
<PAGE>   49

     -    that such broker-dealers did not conduct any investigation to verify
          the information set out or incorporated by reference in this
          prospectus, as supplemented; and

     -    any other facts material to the transaction.

The price at which Nymox will issue the common shares to Jaspas under the stock
purchase agreement will be 94% of current market price, measured as the average
daily price of the common shares as traded on the Nasdaq SmallCap Market, for
each day in the pricing period with respect to each draw down request, all as
further defined in the stock purchase agreement. Assuming an average daily price
of $3.00 (based on recent daily prices of the common shares as traded on the
Nasdaq SmallCap Market in December 1999), assuming Nymox uses the entire $12
million of financing available under the stock purchase agreement, and assuming
that Nymox does not issue any more than the shares registered under the
registration statement of which this prospectus is a part, underwriting
compensation for Jaspas based on the discounted purchase price will be $765,957,
or $0.18 per share.

LIMITED GRANT OF REGISTRATION RIGHTS

Nymox granted the registration rights to Jaspas described under the section
entitled "The Common Stock Purchase Agreement".

In connection with any such registration, Nymox will have no obligation:

     -    to assist or cooperate with Jaspas in the offering or disposition of
          such shares;

     -    to indemnify or hold harmless the holders of any such shares (other
          than Jaspas) or any underwriter designated by such holders;

     -    to obtain a commitment from an underwriter relative to the sale of any
          such shares; or

     -    to include such shares within an underwriting offering of Nymox.

Nymox will assume no obligation or responsibility whatsoever to determine a
method of disposition for such shares or to otherwise include such shares within
the confines of any registered offering other than the registration statement of
which this prospectus is a part.

Nymox will use its best efforts to file, during any period during which it is
required to do so under its registration rights agreement with Jaspas, one or
more post-effective amendments to the registration statement of which this
prospectus is a part to describe any material information with respect to the
plan of distribution not previously disclosed in this prospectus or any material
change to such information in this prospectus. See the section above entitled
"The Common Stock Purchase Agreement."


                                       47
<PAGE>   50

                   CANADIAN FEDERAL INCOME TAX CONSIDERATIONS

The following is, as of the date of this prospectus, a summary of the principal
Canadian federal income tax considerations generally applicable to shareholders
who receive a dividend from Nymox and who, at all relevant times, for purposes
of the Income Tax Act (Canada) the ("Tax Act"), hold and will hold Nymox common
shares as capital property and deal with Nymox at arm's length.

Nymox's common shares will generally constitute capital property to a holder
unless the holder holds such shares in the course of carrying on a business or
the holder has acquired such shares in a transaction or transactions considered
to be an adventure in the nature of trade. This summary is based on the current
provisions of the Tax Act, the regulations under that act, counsel's
understanding of current administrative and assessing policies of the Canada
Customs and Revenue Agency and all specific proposals to amend the Tax Act
publicly announced or released by or on behalf of the Minister of Finance
(Canada) before the date of this prospectus ("Tax Proposals").

The Tax Act contains certain provisions relating to securities held by certain
financial institutions (the "Mark-to-Market Rules"). This summary does not take
into account these Mark-to-Market Rules or any amendments to them contained in
the Tax Proposals and taxpayers that are "financial institutions" for purposes
of those rules should consult their own tax advisors.

This summary is not exhaustive of all possible Canadian federal income tax
considerations and, except for the Tax Proposals, does not take into account or
anticipate any changes in law, whether by legislative, governmental or judicial
action, nor does it take into account tax legislation of any province, territory
or foreign jurisdiction. This summary is of a general nature only and is not
intended to be, nor should it be construed as, legal or tax advice to any
particular holder of Nymox common shares.

CANADIAN RESIDENTS

The following summary is relevant to a holder of Nymox common shares who, for
purposes of the Tax Act and any applicable tax treaty or convention, is resident
in Canada at all relevant times.

Tax Treatment of Capital Gains and Capital Losses for Canadian Residents

On a disposition or deemed disposition of a Nymox common share, the holder will
realize a capital gain (or capital loss) equal to the amount by which the
proceeds of disposition for the Nymox common share exceed (or are less than) the
aggregate of any costs of disposition and the adjusted cost base to the holder
of the Nymox common share immediately before the disposition.


                                       48
<PAGE>   51

A holder of Nymox common shares will be required to include in income
three-quarters of the amount of any capital gain (a "Taxable capital gain") and
may deduct three-quarters of the amount of any capital loss (an "Allowable
capital loss") against Taxable capital gains realized by the holder in the year
of the disposition. Allowable capital losses in excess of Taxable capital gains
may be carried back and deducted in any of the three preceding years or carried
forward and deducted in any following year against taxable capital gains
realized in such years to the extent and under the circumstances described in
the Tax Act.

A Canadian-controlled private corporation will also be subject to a refundable
tax of 6 2/3% on certain investment income, including taxable capital gains
realized on the disposition of Nymox common shares, that will be refunded when
the corporation pays taxable dividends (at a rate of $1.00 for every $3.00 of
taxable dividend paid).

A capital loss realized by a holder of Nymox common shares that is a
corporation, a partnership of which a corporation is a member or a trust of
which a corporation is a beneficiary may be reduced by the amount of dividends
received in certain circumstances. Capital gains realized by an individual may
give rise to a liability for alternative minimum tax.

Tax Treatment of Dividends Received by Canadian Residents

In the case of a holder of Nymox common shares who is an individual, any
dividends received on the common shares will be included in computing his income
and will be subject to the gross-up and dividend tax credit rules normally
applicable to taxable dividends paid by taxable Canadian corporations. A holder
that is a corporation may be liable to pay refundable tax under Part IV of the
Tax Act. However, a public corporation which is not controlled, whether because
of a beneficial interest in one or more trusts or otherwise, by or for the
benefit of an individual (other than a trust) or a related group of individuals
(other than trusts) will not be liable to pay refundable tax under Part IV of
the Tax Act.

In the case of a holder of Nymox common shares that is a corporation, the amount
of any capital loss otherwise determined resulting from the disposition of a
Nymox common share may be reduced by the amount of dividends previously received
or deemed to have been received thereon. Any such restriction will not occur
where the corporate holder owned the Nymox common share for 365 days or longer
and such holder (together with any persons with whom it did not deal at arm's
length) did not own more than 5% of the shares of any class or series of Nymox
at the time the relevant dividends were received or deemed to have been
received. Analogous rules apply where a corporation is a member of a partnership
or a beneficiary of a trust, which owns Nymox common shares.

SHAREHOLDERS WHO ARE NOT RESIDENTS OF CANADA

The following summary is relevant to a holder of Nymox common shares, who, at
all relevant times, for purposes of the Tax Act and any applicable tax treaty or
convention, is a non-resident or is deemed to be a non-resident of Canada and
does not use and is not deemed to use or hold Nymox common shares in the course
of carrying on a business in Canada. Special rules, which are not discussed
below, may apply to a non-resident that is an insurer which carries on business
in Canada and elsewhere.


                                       49
<PAGE>   52

Dividends Paid to Non-Residents of Canada

Under the Tax Act, dividends paid or credited to a non-resident are subject to
withholding tax at the rate of 25% of the gross amount of the dividends. This
withholding tax may be reduced or eliminated pursuant to the terms of an
applicable tax treaty between Canada and the country of residence of the
non-resident. For example, for persons who are resident in the United States for
purposes of the Canada-United States Income Tax Convention, (the "Convention")
the rate of withholding tax on dividends is reduced to 15% generally and 5% when
the United States resident is a company that beneficially owns at least 10% of
the voting stock of the company paying the dividends.

Under the Convention, dividends paid to certain religious, scientific,
charitable and other similar tax-exempt organizations and certain organizations
that are resident in, and exempt from tax in, the United States are exempt from
Canadian non-resident withholding tax. Provided that certain administrative
procedures designed to establish with the Canadian tax authorities the right of
such entities to benefit from this withholding tax exemption are complied with
by the tax-exempt entities prior to the Distribution, Nymox would not be
required to withhold such tax on such payment. Alternatively, the
above-described tax-exempt entities may claim a refund of Canadian withholding
tax otherwise withheld by Nymox on the distribution of dividends.

Tax Treatment of Capital Gains of Non-Residents of Canada

On a disposition or deemed disposition of a Nymox common share, a non-resident
holder will realize a capital gain (or capital loss) equal to the amount by
which the proceeds of disposition for the Nymox common share exceed (or are less
than) the aggregate of any costs of disposition and the adjusted cost base to
the non-resident holder of the Nymox common share immediately before the
disposition.

A non-resident of Canada is liable for Canadian income tax on a capital gain
realized on the disposition of property only where that property constitutes
"taxable Canadian property". Three-quarters of any capital gain from the
disposition of taxable Canadian property is subject to Canadian tax.

Under the Tax Act, shares of Nymox will not constitute taxable Canadian property
unless, at any time, in the five years immediately preceding the disposition,
the non-resident holder, persons with whom the non-resident holder did not deal
at arms length, or the non-resident holder together with all such persons owned
(or had a right to acquire) 25% or more of the shares of any class of Nymox.
Even in circumstances where shares of Nymox are taxable Canadian property to a
non-resident holder, the non-resident holder may be entitled to relief from
Canadian tax on any capital gain realized on the disposition thereof pursuant to
the terms of an applicable tax treaty between Canada and the country of
residence of the non-resident. For example, the Convention provides that gains
realized by a resident of the United States on the disposition or deemed
disposition of shares of a company will generally not be subject to tax under
the Tax Act, provided that the value of the shares is not derived principally
from real property situated in Canada. Nymox believes that the value of its
shares is not currently derived principally from real property situated in
Canada and it does not expect this to change in the foreseeable future.


                                       50
<PAGE>   53

Provided that the Nymox common shares remain listed on a prescribed stock
exchange, which includes the Nasdaq SmallCap Market System, a non-resident
holder who disposes of Nymox common shares will not be required to comply with
the Canadian notification procedures generally applicable to dispositions of
taxable Canadian property.

                     U.S. FEDERAL INCOME TAX CONSIDERATIONS

The following is, as of the date of this prospectus, a general summary of the
material U.S. federal income tax consequences that are applicable to the
following persons who, under this prospectus, directly or indirectly, acquire
common shares of Nymox and hold such common shares as capital assets:

     -    citizens or residents (as specially defined for federal income tax
          purposes) of the United States,

     -    corporations or partnerships created or organized in the United States
          or under the laws of the United States or any state,

     -    estates the income of which is subject to the United States federal
          income taxation regardless of its source and

     -    a trust, if a U.S. court is able to exercise primary supervision over
          the administration of such trust and one or more U.S. persons have the
          authority to control all substantial decisions of such trust or a
          trust that has been elected to be treated as a domestic trust (U.S.
          Shareholders).

This discussion does not deal with:

     -    any aspects of federal income taxation that may be relevant to a
          particular U.S. Shareholder based on his particular circumstances
          (including potential application of the alternative minimum tax or
          unrelated business income tax),

     -    certain U.S. Shareholders subject to special treatment under the
          federal income tax laws or foreign individuals or entities,

     -    U.S. Shareholders owning directly or by attribution 10% or more of the
          common shares or

     -    any aspect of state, local or non-United States tax laws.


                                       51
<PAGE>   54

DIVIDENDS PAID ON COMMON SHARES

Subject to the application of the rules relating to a "passive foreign
investment company", referred to as a PFC, distributions paid on common shares
(including any Canadian taxes withheld) to a U.S. Shareholder will be treated as
ordinary income for United States federal income tax purposes to the extent of
Nymox's current and accumulated earnings and profits (as computed for U.S.
federal income tax purposes). Distributions in excess of such earnings and
profits will be applied against the U.S. shareholders tax basis in common
shares, and any distributions in excess of such tax basis will be treated as
gain from the sale or exchange of such common shares. Distributions from Nymox
generally will not qualify for the United States dividends-received deduction
available to corporations. Canadian withholding tax withheld or paid will be
eligible for credit or, at the U.S. Shareholder's election, deduction, subject
to generally applicable limitations.

DISPOSITION OF COMMON SHARES

Subject to the applicable PFC rules discussed below, if a U.S. Shareholder holds
common shares as a capital asset, any gain or loss on a sale or exchange of such
shares will be capital gain or loss, which will be long-term capital gain or
loss if the holding period is one year or more. Generally, the maximum tax rate
for U.S. shareholders who are individuals on long term capital gain is 20%. The
sale of common shares through certain brokers will be subject to the information
reporting and back-up withholding rules of the United States Internal Revenue
Code of 1986, as amended, referred to as the Code.

PASSIVE FOREIGN INVESTMENT COMPANY

For any taxable year of Nymox, if at least 75% of Nymox's gross income is
"passive income" as defined in the Code, or if at least 50% of Nymox's assets,
by average fair market value, are assets that produce or are held for the
production of passive income, Nymox will be a PFC. The PFC determination is made
on the basis of facts and circumstances that may be beyond Nymox's control. It
is not possible to express an opinion as to whether or not Nymox is or will be a
PFC in its current or future taxable years because this depends on, among other
things, the amount and type of gross income that Nymox will earn in the future
and the characterization of certain assets as passive or active, which
determination cannot be made until the facts are known.

If Nymox is a PFC for any taxable year during which a U.S. Shareholder owns,
directly or indirectly, any common shares, the U.S. Shareholder will be subject
to special U.S. federal income tax rules, set forth in Sections 1291 to 1297 of
the Code, with respect to all of such U.S. Shareholder's common shares. In the
absence of (i) an election by such U. S. Shareholder to treat Nymox as a
"qualified electing fund" (the "Q.E.F. Election"), as discussed below, or (ii)
the election to mark to market the common shares (the "Mark to Market
Election"), as described below, the U.S. Shareholder would be required to report
any gain on the disposition of any common shares as ordinary income rather than
capital gain and to compute the tax liability on such gain as well as on any
"excess distribution" as defined in the Code, as if such amounts generally had
been earned pro-rata over the U.S. Shareholder's holding period for such common
shares and were subject to the highest ordinary income tax rate for each taxable
year of the U.S. Shareholder during such holding period. Such U.S. Shareholder
would also be liable for interest, which may be non-deductible by certain U.S.
Shareholders, on the foregoing tax liability as if such liability had been due
with respect to each such prior year. In addition, gifts, exchanges pursuant to
corporate reorganizations and the use of common shares as security for a loan
may be treated as taxable dispositions, and a stepped-up basis upon the death of
such a U.S. Shareholder may not be available.


                                       52



<PAGE>   55

The foregoing rules may be avoided if a Q.E.F. Election is in effect with
respect to a U. S. Shareholder for each of the years that Nymox is a PFC during
such U.S. Shareholder's holding period. A Q.E.F. Election may be made by a U.S.
Shareholder on or before the due date, including extensions, for filing such
U.S. Shareholder's tax return for such taxable year. Such a U.S. Shareholder
would be taxed on its pro-rata share of Nymox's earnings and profits for Nymox's
taxable year in which it was, or was treated as, a PFC and which ends with or
within such U.S. Shareholder's taxable year, regardless of whether such amounts
are actually distributed by Nymox. This may result in tax liability without a
commensurate distribution with which to pay the liability. An electing U.S.
Shareholder's basis in the common shares would be increased by the amounts
included in income. Distributions out of earnings and profits previously
included by such U.S. Shareholder generally would not be treated as a taxable
dividend for United States federal income tax purposes and would result in a
corresponding reduction of basis in common shares. An electing U.S. Shareholder
will not be currently taxed on the undistributed ordinary income and net capital
gain of Nymox for any year that Nymox is not classified as a PFC.

If Nymox is a PFC, a U.S. Shareholder may avoid certain of the tax consequences
described in the preceding two paragraphs if the Nymox common stock is
marketable and meets the other requirements of Section 1296 of the Code, and the
U.S. Shareholder elects to mark to market the common stock on an annual basis.
The common stock will be marketable so long as it is regularly traded on a
recognized exchange.

In general, a U.S. Shareholder in a PFC who elects under Section 1296 to mark
the common stock to market would include in income each year an amount equal to
the excess, if any, of the fair market value of the common stock as of the close
of the taxable year over the U.S. Shareholder's adjusted basis in such stock. A
U.S. Shareholder who makes the Section 1296 election would also generally be
allowed a deduction for the excess, if any, of the adjusted basis of the common
stock over the fair market value as of the close of the taxable year. Deductions
under this rule, however, are allowable only to the extent of any net mark to
market gains with respect to the common stock included by the shareholder for
prior taxable years.

Once the Mark to Market election is made, it is binding for all subsequent
years, unless the common stock ceases to be marketable, or the IRS consents to
the revocation of the election.


                                       53



<PAGE>   56

If Nymox is a PFC, each U.S. Shareholder is strongly urged to consult with his
or her tax advisor to determine whether the Q.E.F. Election or the Mark to
Market Election should be made. Each requires attention to specific rules and
regulations, and each may not be available to a specific U.S. shareholder.

Nymox intends to notify its U.S. Shareholders within 45 days after the end of
the taxable year for which Nymox believes it might be a PFC. Nymox has further
undertaken (i) to provide its U.S. Shareholders with timely and accurate
information as to its status as a PFC and the manner in which the Q.E.F.
Election can be made and (ii) to comply with all record-keeping, reporting and
other requirements so that U.S. Shareholders, at their option, may make a Q.E.F.
Election.

FUTURE DEVELOPMENTS

The foregoing discussion is based on existing provisions of the Code, existing
and proposed regulations thereunder and current administrative rulings and court
decisions, all of which are subject to change. Any such changes could affect the
validity of this discussion. In addition, the implementation of certain aspects
of the PFC rules requires the issuance of regulations which in many instances
have not been promulgated and which may have retroactive effect.

There can be no assurance that current authorities will not be changed and, if
so, as to the form they will take or the effect they may have on this
discussion.

                      DESCRIPTION OF NYMOX'S COMMON SHARES

Nymox has only one class of capital stock, known as common shares. Nymox is
authorized to issue an unlimited number of its common shares. As of the date of
this prospectus, there were 20,003,804 Nymox common shares outstanding.

RIGHTS OF HOLDERS OF COMMON SHARES

Holders of Nymox common shares are entitled to one vote for each share held on
all matters submitted to a vote of shareholders. They do not have cumulative
voting rights.

Holders of Nymox common shares are entitled to receive such dividends, if any,
as may be declared by the board of directors of Nymox out of funds legally
available for dividends. Nymox does not intend currently to pay dividends on its
common shares.

Upon liquidation, dissolution or winding up of Nymox, the holders of Nymox
common shares are entitled to receive the assets of Nymox on a pro rata basis.
Holders of Nymox common shares have no preemptive, subscription, redemption or
conversion rights.


                                       54




<PAGE>   57

SHAREHOLDER MEETINGS

Under applicable Canadian securities legislation and the Canada Business
Corporations Act, a meeting of the shareholders of a company must be convened at
least once every fifteen months. Meetings of the shareholders of Nymox shall be
held at the registered office of Nymox or elsewhere in the municipality where
the registered office is situate or, if the board so determines, elsewhere in
Canada, or, if all the shareholders entitled to vote at the meeting so agree,
outside of Canada.

Notice of all annual and special meetings of the shareholders of Nymox must be
given to shareholders entitled to vote at such meeting, setting out the place,
the day and the hour of the meeting and the general nature of the business to be
considered.

The by-laws of Nymox provide that a quorum for the transaction of any business
at any meeting of shareholders shall be persons present and holding or
representing by proxy at least 33 1/3% of the shares entitled to vote at the
meeting.

NUMBER OF DIRECTORS

Nymox's articles provide that there shall be a minimum of five directors and a
maximum of fifteen directors. The board of directors fixes the exact number of
directors to be proposed for election in each year. The Canada Business
Corporations Act also requires that Nymox have a minimum of three directors, at
least two of which are not officers or employees of Nymox or its affiliates.

CANADIAN RESIDENCY REQUIREMENTS FOR DIRECTORS

The Canada Business Corporations Act requires that a majority of the directors
of Nymox be resident Canadians, which the act defines to mean, subject to
certain exceptions, persons ordinarily resident in Canada who are either
Canadian citizens or permanent residents of Canada within the meaning of that
phrase in the Immigration Act (Canada).

FILLING VACANCIES ON THE BOARD OF DIRECTORS

The articles of Nymox provide, in accordance with the Canada Business
Corporations Act, that the directors of Nymox have the right to appoint one or
more additional directors, who shall hold office for a term expiring not later
than the close of the next annual meeting of shareholders. The total number of
directors so appointed may not exceed one third of the number of directors
elected at the previous annual meeting of shareholders.

REMOVAL OF DIRECTORS

The directors of Nymox may be removed from office by a resolution passed by a
majority of the votes cast at a special meeting of shareholders.


                                       55



<PAGE>   58

LIMITATIONS ON LIABILITY OF OFFICERS AND DIRECTORS

Nymox's bylaws provide that, subject to the limitations in the Canada Business
Corporations Act, Nymox shall indemnify a director or officer, a former director
or officer, or a person who acts or acted at Nymox's request as a director or
officer of a body corporate of which Nymox is or was a shareholder or creditor
(or a person who undertakes or has undertaken any liability on behalf of Nymox
or any such body corporate) and his or her heirs and legal representatives
against all costs, charges and expenses, including an amount paid to settle an
action or satisfy a judgment, reasonably incurred by him in respect of any
civil, criminal or administrative action or proceeding to which he or she is a
party be reason of being or having been a director or officer of Nymox or such
body corporate, if he or she acted honestly and in good faith with a view to the
best interests of Nymox and, in the case of a criminal or administrative action
or proceeding that is enforced by a monetary penalty, he or she had reasonable
grounds for believing that his or her conduct was lawful.

The Canada Business Corporations Act permits Nymox to so indemnify such
officers, directors and other persons except in respect of an action by or on
behalf of Nymox or a body corporate of which Nymox is or was a shareholder or
creditor to procure a judgment in its favor.

AMENDMENT OF CERTAIN PROVISIONS OF THE ARTICLES; FUNDAMENTAL CHANGES

The Canada Business Corporation Act requires, except in limited circumstances,
the approval of not less than two-thirds of the votes of the shareholders voting
in person or by proxy at a special meeting of the shareholders to amend the
articles of Nymox or to amalgamate or dissolve Nymox.

                              CERTAIN LEGAL MATTERS

The validity of the common shares offered hereby will be passed upon for Nymox
by Foley & Lardner, 3000 K Street, N.W., Washington, DC 20007. Foley & Lardner
will rely as to all matters of Canadian laws on the opinion of Stikeman Elliott,
1155 Rene Levesque Blvd. W., Montreal, QC H3B 3V2.

                                     EXPERTS

The financial statements of Nymox as at December 31, 1998 and 1997 for each of
the years in the three year period ended December 31, 1998 included in this
prospectus and in the registration statement have been audited by KPMG,
independent auditors, and are included in this prospectus and in this
registration statement in reliance upon such report, and upon the authority of
KPMG as experts in accounting and auditing.


                                       56



<PAGE>   59

                       WHERE YOU CAN FIND MORE INFORMATION

Nymox is subject to the informational requirements of the Exchange Act and in
accordance with that Act files reports and other information with the SEC. You
may inspect and copy any such reports and other information filed by Nymox with
the SEC, including the registration statement on Form F-1 of which this
prospectus is a part, at the public reference facilities of the Commission at
Judiciary Plaza, 450 Fifth Street, N.W., Room 1024, Washington, D.C. 20549, and
at the SEC's Regional Offices at Seven World Trade Center, Suite 1300, New York
l0048 and Northwest Atrium Center 600 West Madison Street, Suite 1400, Chicago,
IL 60561. You may obtain copies of such material, at prescribed rates, by a
written request addressed to the Commission at the Public Reference Section at
450 Fifth Street, N.W. Washington, D.C. 20549. The public may obtain information
on the operation of the SEC's public reference facilities by calling the SEC at
1-8OO-SEC-0330. In addition, the common shares are listed on the Nasdaq SmallCap
Market and reports and other information concerning Nymox may also be inspected
at the offices of the Nasdaq Stock Market, Inc., Nasdaq Listing Qualifications,
9801 Washingtonian Boulevard, Rockville, MD 20878. In addition, Nymox will
provide without charge to each person to whom this prospectus is delivered, upon
either the written or oral request of such person, the Annual Report to
Shareholders for Nymox's latest fiscal year. Such requests should be directed to
Roy Wolvin, CFO of Nymox Pharmaceutical Corporation, 9900 Cavendish Blvd., Suite
306, St. Laurent, QC, Canada H4M 2V2, telephone 1-800-936-9669.

                  ENFORCEMENT OF CERTAIN CIVIL LIABILITIES AND
                 AUTHORIZED REPRESENTATIVE IN THE UNITED STATES

Many of Nymox's directors, officers and certain experts named in this prospectus
are residents of Canada. Consequently, it may be difficult for United States
investors to effect service within the United States upon Nymox's directors,
officers or certain experts named in this prospectus, or to realize in the
United States upon judgments of courts of the United States predicated upon
civil liabilities under the Securities Act. A judgment of a court of the United
States predicated solely upon such civil liabilities would probably be
enforceable in Canada by the Canadian court if the United States court in which
the judgment was obtained had jurisdiction, as determined by the Canadian court,
in the matter. There is substantial doubt whether an original action could be
brought successfully in Canada against any of such persons or Nymox predicated
solely upon such civil liabilities.

The authorized agent to receive service of process in the United States is Nymox
Corporation, 5516 Nicholson Lane, Suite 100A, Kensington, MD 20895, telephone
1-800-93NYMOX.


                                       57



<PAGE>   60

                      Consolidated Financial Statements of

                              NYMOX PHARMACEUTICAL
                                  CORPORATION

                  Years ended December 31, 1998, 1997 and 1996


                                      F-1



<PAGE>   61

                      AUDITORS' REPORT TO THE SHAREHOLDERS

We have audited the consolidated balance sheets of Nymox Pharmaceutical
Corporation as at December 31, 1998 and 1997 and the consolidated statements of
earnings, deficit and changes in financial position for the years ended December
31, 1998, 1997 and 1996. These financial statements are the responsibility of
the Corporation's management. Our responsibility is to express an opinion on
these financial statements based on our audits.

We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform an audit to obtain
reasonable assurance whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.

In our opinion, these consolidated financial statements present fairly, in all
material respects, the financial position of the Corporation as at December 31,
1998 and 1997 and the results of its operations and the changes in its financial
position for the years ended December 31, 1998, 1997 and 1996 in accordance with
generally accepted accounting principles.


KPMG
Chartered Accountants

Montreal, Canada

February 26, 1999


                                      F-2



<PAGE>   62


                        NYMOX PHARMACEUTICAL CORPORATION
                       Consolidated Financial Statements

                  Years ended December 31, 1998, 1997 and 1996


<TABLE>
<S>                                                                                 <C>
     FINANCIAL STATEMENTS

     Consolidated Balance Sheets.................................................   F-4

     Consolidated Statements of Earnings.........................................   F-5

     Consolidated Statements of Deficit..........................................   F-6

     Consolidated Statements of Changes in Financial Position....................   F-7

     Notes to Consolidated Financial Statements..................................   F-8
</TABLE>



                                      F-3


<PAGE>   63


                        NYMOX PHARMACEUTICAL CORPORATION
                          Consolidated Balance Sheets

                           December 31, 1998 and 1997
                             (in Canadian dollars)

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------
                                                                               1998                 1997
- -----------------------------------------------------------------------------------------------------------
<S>                                                                        <C>                  <C>
Assets

Current assets:
     Cash (note 3)                                                        $   714,298          $   507,259
     Short-term investments                                                 2,113,907            1,780,086
     Accrued interest                                                          46,082                4,200
     Receivable due from a financial institution (note 6 (b))                 637,500                   -
     Accounts receivable                                                       74,653                   -
     Research tax credits receivable                                            5,778              150,000
     Notes receivables (note 4)                                               273,995               56,000
     Other receivables                                                         43,028               28,790
- ----------------------------------------------------------------------------------------------------------
                                                                            3,909,241            2,526,335

Capital assets (note 5)                                                     1,846,979            1,419,462

- -----------------------------------------------------------------------------------------------------------
                                                                          $  5,756,220         $  3,945,797
===========================================================================================================

Liabilities and Shareholders' Equity

Current liabilities:
     Accounts payable and accrued liabilities                             $    434,440         $    292,330

Shareholders' equity:
     Capital stock (note 6)                                                 23,011,556           13,852,632
     Capital stock subscription                                                     --              504,000
     Deficit                                                               (17,689,776)         (10,703,165
- -----------------------------------------------------------------------------------------------------------
                                                                             5,321,780            3,653,467

Commitments (note 7)
Subsequent event (note 13)

- -----------------------------------------------------------------------------------------------------------
                                                                          $  5,756,220         $  3,945,797
===========================================================================================================
</TABLE>


See accompanying notes to consolidated financial statements.

On behalf of the Board:


/s/  Paul Averback       Director
- -----------------------


/s/  Colin Bier          Director
- -----------------------


                                      F-4



<PAGE>   64


NYMOX PHARMACEUTICAL CORPORATION
Consolidated Statements of Earnings

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

<TABLE>
<CAPTION>

===========================================================================================================
                                                          1998                 1997                 1996
- -----------------------------------------------------------------------------------------------------------
<S>                                                  <C>                  <C>                   <C>
Revenue:
     Interest                                        $  243,574             $   76,526           $  226,940
     Service fees                                       151,263                 24,584                   --
- -----------------------------------------------------------------------------------------------------------
                                                        394,837                101,110              226,940

Expenses:
     Research and development                         3,019,015              2,562,349            2,356,000
     Less research tax credits                           (5,778)              (150,000)            (240,000)
- -----------------------------------------------------------------------------------------------------------
                                                      3,013,237              2,412,349            2,116,000
     Marketing                                        3,240,242              1,925,654            1,253,894
     General and administrative                         896,201                589,524              497,179
     Depreciation and amortization                      135,551                158,694               78,906
     Interest and bank charges                           13,217                 14,344                8,025
- -----------------------------------------------------------------------------------------------------------
                                                      7,298,448              5,100,565            3,954,004
- -----------------------------------------------------------------------------------------------------------
Loss before income taxes                             (6,903,611)            (4,999,455)          (3,727,064)
Income taxes (note 8)                                        --                     --               28,000
- -----------------------------------------------------------------------------------------------------------
Net loss                                            $(6,903,611)           $(4,999,455)         $(3,699,064)
===========================================================================================================
Loss per share                                      $     (0.36)           $     (0.27)         $     (0.21)
===========================================================================================================
Weighted average number of common
   shares outstanding                                19,304,435             18,370,873           17,654,862
===========================================================================================================
</TABLE>


See accompanying notes to consolidated financial statements.


                                      F-5
<PAGE>   65

NYMOX PHARMACEUTICAL CORPORATION
Consolidated Statements of Deficit

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------------------
                                                          1998                 1997                 1996
- ------------------------------------------------------------------------------------------------------------

<S>                                                  <C>                    <C>                  <C>
Deficit, beginning of year                           $(10,703,165)          $ (5,472,710)        $(1,539,686)

Net loss                                               (6,903,611)            (4,999,455)         (3,699,064)

Share issue costs                                         (83,000)              (231,000)           (233,960)

- ------------------------------------------------------------------------------------------------------------
Deficit, end of year                                 $(17,689,776)          $(10,703,165)        $(5,472,710)
============================================================================================================
</TABLE>


See accompanying notes to consolidated financial statements.


                                      F-6



<PAGE>   66


NYMOX PHARMACEUTICAL CORPORATION
Consolidated Statements of Changes in Financial Position

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

<TABLE>
<CAPTION>
- --------------------------------------------------------------------------------------------------------
                                                         1998                 1997               1996
- --------------------------------------------------------------------------------------------------------

<S>                                                  <C>                 <C>                 <C>
Cash provided by (used in):

Operations:
     Net loss                                        $(6,903,611)        $(4,999,455)        $(3,699,064)
     Items not involving cash:
         Depreciation and amortization                   135,551             158,694              78,906
     Net change in non-cash operating
       working capital items                            (481,941)             58,421             (55,855)
- --------------------------------------------------------------------------------------------------------
                                                      (7,250,001)         (4,782,340)         (3,676,013)

Financing:
     Issuance of capital stock                         8,654,924           4,549,941           5,280,050
     Subscription to capital stock                            --             504,000                  --
     Share issue costs                                   (83,000)           (231,000)           (233,960)
- --------------------------------------------------------------------------------------------------------
                                                       8,571,924           4,822,941           5,046,090

Investments:
     Additions to capital assets                        (563,068)           (260,183)         (1,030,724)
     Notes receivable                                   (217,995)                 --                  --
- --------------------------------------------------------------------------------------------------------
                                                        (781,063)            (260,183)        (1,030,724)
- --------------------------------------------------------------------------------------------------------
Increase (decrease) in cash and
   short-term investments                                540,860             (219,582)           339,353

Cash and short-term investments,
   beginning of year                                   2,287,345            2,506,927          2,167,574

- --------------------------------------------------------------------------------------------------------
Cash and short-term investments,
   end of year                                       $ 2,828,205          $ 2,287,345         $2,506,927
========================================================================================================
</TABLE>


See accompanying notes to consolidated financial statements.


                                      F-7



<PAGE>   67


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


1.   ORGANIZATION AND BUSINESS ACTIVITIES:

     Nymox Pharmaceutical Corporation (the "Corporation"), incorporated under
     the Canada Business Corporations Act, is a development stage
     biopharmaceutical corporation which specializes in the research and
     development of neurological therapeutics and diagnostics for the aging
     population, with an emphasis on Alzheimer's disease.

     Since inception, the Corporation's activities have been primarily focused
     on developing certain pharmaceutical technologies and obtaining outside
     funding to support the continued development of its technologies. The
     Corporation is subject to a number of risks, including the successful
     development and marketing of its technologies. In order to achieve its
     business plan, the Corporation anticipates the need to raise additional
     capital. Management is confident that it will be able to obtain the
     continued financial support of its shareholders and/or new external
     financing to pursue its development.

     The Corporation is listed on the Montreal Exchange and the NASDAQ Stock
     Market.

2.   SIGNIFICANT ACCOUNTING POLICIES:

     (a) Consolidation:

         The consolidated financial statements of the Corporation have been
         prepared under Canadian generally accepted accounting principles
         ("GAAP") and include the accounts of its wholly-owned US subsidiary,
         Nymox Corporation. Intercompany balances and transactions have been
         eliminated on consolidation.

         Consolidated financial statements prepared under US GAAP would differ
         in some respects from those prepared in Canada. A reconciliation of
         earnings and shareholders' equity reported in accordance with Canadian
         GAAP with US GAAP is presented in note 10.

     (b) Short-term investments:

         The Corporation's portfolio of short-term investments, which does not
         include equity securities, consists principally of government
         securities and commercial paper that are highly liquid and readily
         convertible into cash. These are recorded at the lower of cost or
         market value.


                                      F-8
<PAGE>   68


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


2.   SIGNIFICANT ACCOUNTING POLICIES (CONTINUED):

     (c) Capital assets:

         Capital assets are recorded at cost. Depreciation and amortization are
         provided using the following methods and annual rates:

<TABLE>
<CAPTION>

=======================================================================================================================
         Asset                                                                 Method                     Rate
- -----------------------------------------------------------------------------------------------------------------------
         <S>                                                                <C>                           <C>
         Computer equipment                                                 Straight-line                  20%
         Laboratory equipment                                               Straight-line                  20%
         Office equipment and fixtures                                      Straight-line                  20%

========================================================================================================================
</TABLE>


          The capitalized amount with respect to patents relates to direct costs
          incurred in connection with securing the patents. The cost of the
          patents does not necessarily reflect their present or future value and
          the amount ultimately recoverable is dependent upon the successful
          commercialization of the related products. Accordingly, patents will
          be amortized using the straight-line method commencing in the year of
          commercial production of the developed products. The capitalized
          amount will be amortized over the remaining years of the initial life
          of the patent.

     (d)  Research and development expenditures:

          Research expenditures, net of research tax credits, are expensed as
          incurred. Development expenditures, net of tax credits, if any, are
          expensed as incurred, except if they meet the criteria for deferral in
          accordance with generally accepted accounting principles.

     (e)  Foreign exchange:

          The Corporation's foreign subsidiary is considered to be an integrated
          foreign operation. Foreign denominated monetary assets and liabilities
          of the Canadian and foreign operations are translated at the rates of
          exchange prevailing at the balance sheet dates. Other assets and
          liabilities denominated in foreign currencies are translated at the
          exchange rates prevailing when the assets were acquired or the
          liabilities incurred. Sales and expenses are translated at the average
          exchange rate prevailing during the year, except for depreciation and
          amortization which are translated at the same rates as those used in
          the translation of the corresponding assets. Foreign exchange gains
          and losses are included in the determination of net earnings.


                                      F-9
<PAGE>   69


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


2.   SIGNIFICANT ACCOUNTING POLICIES (CONTINUED):

     (f)  Use of estimates:

          The preparation of financial statements in conformity with generally
          accepted accounting principles requires management to make estimates
          and assumptions that affect the reported amounts of assets and
          liabilities and disclosure of contingent liabilities at the date of
          the financial statements and the reported amounts of revenues and
          expenses during the reporting period. Actual results could differ from
          those estimates.

     (g)  Loss per share:

          The loss per share amounts has been calculated using the weighted
          average number of common shares outstanding during the year. Fully
          diluted loss per share has not been disclosed because the effect of
          common shares issuable upon the exercise of options and warrants would
          be anti-dilutive.

3.   CASH:

     Cash includes $542,953 of cash held in trust by the Corporation's legal
     counsel at December 31, 1998. This amount, which was received from the
     closing of various private placements in December 1998, was released to the
     Corporation in January 1999.

4.   NOTES RECEIVABLE:

<TABLE>
<CAPTION>

======================================================================================================================
                                                                                      1998           1997
- ----------------------------------------------------------------------------------------------------------------------

     <S>                                                                            <C>            <C>
     Note receivable, unsecured, non-interest bearing, payable on demand            $ 56,000       $56,000

     Note receivable,  unsecured,  bearing interest at 9% per annum beginning
       February 1, 1999, payable on demand                                           217,995             -

- ----------------------------------------------------------------------------------------------------------------------
                                                                                    $273,995       $56,000
======================================================================================================================
</TABLE>


     The notes are receivable from a director, who was no longer associated with
     the Company as of March 1999.


                                      F-10



<PAGE>   70


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


5.   CAPITAL ASSETS:

<TABLE>
<CAPTION>

======================================================================================================================
                                                                                                        1998
- ----------------------------------------------------------------------------------------------------------------------
                                                                              Accumulated            Net book
                                                                Cost         depreciation               value
- ----------------------------------------------------------------------------------------------------------------------

     <S>                                                   <C>                   <C>                <C>
     Computer equipment                                    $   78,438            $ 25,528           $   52,910
     Laboratory equipment                                     717,820             220,468              497,352
     Office equipment and fixtures                             38,956              11,687               27,269
     Patents                                                1,276,318               6,871            1,269,447
     Intellectual property rights                                   1                  -                     1
- ----------------------------------------------------------------------------------------------------------------------
                                                           $2,111,533            $264,554           $1,846,979
======================================================================================================================
</TABLE>

<TABLE>
<CAPTION>

======================================================================================================================
                                                                                                         1997
- ----------------------------------------------------------------------------------------------------------------------
                                                                              Accumulated            Net book
                                                            Cost             depreciation               value
- ----------------------------------------------------------------------------------------------------------------------

     <S>                                               <C>                  <C>                  <C>

     Computer equipment                               $   55,803                 $ 15,174           $   40,629
     Laboratory equipment                                734,041                  217,299              516,742
     Office equipment and fixtures                        26,475                    6,449               20,026
     Patents                                             842,064                        -              842,064
     Intellectual property rights                              1                        -                    1
- ----------------------------------------------------------------------------------------------------------------------
                                                      $1,658,384                 $238,922           $1,419,462
======================================================================================================================
</TABLE>


6.   CAPITAL STOCK:

<TABLE>
<CAPTION>
======================================================================================================================
                                                                              1998               1997
- ----------------------------------------------------------------------------------------------------------------------

     <S>                                                                  <C>                  <C>
     Authorized:
         An unlimited number of common shares

     Issued and outstanding:
         19,727,904 common shares (1997 - 18,632,873)                      $23,011,556          $13,852,632
======================================================================================================================
</TABLE>


                                      F-11




<PAGE>   71


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


6.   CAPITAL STOCK (CONTINUED):

     (a) Changes in the Corporation's capital stock are presented below:

<TABLE>
<CAPTION>
======================================================================================================================
                                                                                 Shares               Dollars
- ----------------------------------------------------------------------------------------------------------------------

         <S>                                                                   <C>              <C>
         Issued and outstanding, December 31, 1996                             17,929,382       $    9,302,691

         Issue of common shares for cash (b)                                      696,491            4,527,191

         Issue of common shares pursuant to exercise of
           stock options                                                            7,000               22,750
- ----------------------------------------------------------------------------------------------------------------------
         Balance, December 31, 1997                                            18,632,873           13,852,632

         Issue of common shares for cash (b)                                      366,000            3,131,500

         Cancellation of shares (c)                                                  (460)                  -

         Issue of common shares pursuant to exercise
           of warrants                                                            696,491            5,920,174

         Issue of common shares pursuant to exercise
           of stock options                                                        33,000              107,250
- ----------------------------------------------------------------------------------------------------------------------
         Balance, December 31, 1998                                            19,727,904       $   23,011,556
======================================================================================================================
</TABLE>


     (b)  Private placements:

          In 1998, the Corporation completed private placements for 366,000
          common shares for total aggregate proceeds of $3,131,500. At December
          31, 1998, proceeds of $637,500 for the issuance of 75,000 common
          shares were receivable. These funds were received by the Corporation
          in January 1999.

          In 1997, the Corporation completed a private placement of 696,491
          common shares at a price of $6.50/share and received gross proceeds of
          $4,527,191.

          The share issue costs related to these private placements have been
          charged against the deficit.


                                      F-12
<PAGE>   72


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


6.   CAPITAL STOCK (CONTINUED):

     (c)  Cancellation of shares:

          During the year, the Corporation was advised by its transfer agent
          that common shares of the Corporation, which had been issued on the
          amalgamation of the Company with Monterey Capital Inc. in 1995, were
          never claimed. These common shares have been cancelled.

     (d)  Warrants:

          The Corporation has issued the following warrants to purchase common
          shares:

<TABLE>
<CAPTION>
=======================================================================================================================
                            Exercise                                    Outstanding at
                           price per                     Exercised        December 31,
         Warrants              share       Issued          to date                1998                  Expiry
- -----------------------------------------------------------------------------------------------------------------------

         <S>               <C>            <C>              <C>                  <C>         <C>
         Series A          $    8.50      696,491          696,491                  -                       -
         Series B               8.50       50,000               -               50,000         August 31, 1999
         Series C              10.00       60,000               -               60,000         August 31, 1999
         Series D              10.00       67,500               -               67,500       December 31, 1999
=======================================================================================================================
</TABLE>


         The Series A warrants were issued in connection with the 1997 private
         placement and were exercised in 1998. The Series B, C and D warrants
         were issued in connection with various private placements completed in
         1998. As at December 31, 1998, none of these warrants had been
         exercised.

     (e)  Stock options:

          The Corporation has established a stock option plan (the "Plan") for
          its key employees, its officers and directors, and certain
          consultants. The Plan is administered by the Board of Directors of the
          Corporation. The Board may from time to time designate individuals to
          whom options to purchase common shares of the Corporation may be
          granted, the number of shares to be optioned to each, and the option
          price per share. The option price per share cannot involve a discount
          to the market price at the time the option is granted. The total
          number of shares to be optioned to any one individual cannot exceed 5%
          of the total issued and outstanding shares and the maximum number of
          shares which may be optioned under the Plan cannot exceed 2,500,000
          common shares without shareholder approval.


                                      F-13



<PAGE>   73


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------

6.   CAPITAL STOCK (CONTINUED):

     (e) Stock options (continued):

          Changes in outstanding options were as follows for the last two fiscal
          periods:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                                                 Stock options
- -----------------------------------------------------------------------------------------------------------------------

         <S>                                                                                         <C>
         Balance, December 31, 1996                                                                  1,575,000

         Granted                                                                                       271,000

         Exercised                                                                                      (7,000)

         Cancelled                                                                                      (5,000)

- -----------------------------------------------------------------------------------------------------------------------
         Balance, December 31, 1997                                                                  1,834,000

         Granted                                                                                       125,000

         Exercised                                                                                     (33,000)

         Cancelled                                                                                          -

- -----------------------------------------------------------------------------------------------------------------------
         Balance, December 31, 1998                                                                  1,926,000
=======================================================================================================================
</TABLE>


          The weighted average exercise prices of options granted, exercised and
          cancelled during 1998 were $6.59/share (1997 - $9.42/share),
          $3.25/share (1997 - $3.25/share) and nil/share (1997 - $11.50/share),
          respectively. The weighted average exercise price of options
          exercisable at December 31, 1998 is $5.95/share (1997 - $5.10/share).

          At December 31, 1998, options outstanding were as follows:

<TABLE>
<CAPTION>
=======================================================================================================================
         Options outstanding                                 Exercise price  per share             Expiry date

<S>                                                                  <C>                           <C>
               25,000                                                  $4.90                               1999
               30,000                                                 $10.00                               1999
              100,000                                                  $7.00                               2002
               40,000                                                 $13.75                               2006
               40,000                                                  $9.80                               2006
              110,000                                                 $11.50                               2006
               10,000                                                 $16.75                               2006
               40,000                                                  $9.00                               2006
                5,000                                                  $9.25                               2007
            1,200,000                                                  $3.25 (i)                    2006 - 2009
               36,000                                                  $9.25 (ii)                   2006 - 2010
              290,000                                                 $10.00 (iii)                  2006 - 2012
- -----------------------------------------------------------------------------------------------------------------------
            1,926,000
=======================================================================================================================
</TABLE>


                                      F-14

<PAGE>   74


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


6.   CAPITAL STOCK (CONTINUED):

     (d) Stock options (continued):

         (i)    These options are effective and exercisable as follows:

<TABLE>


=======================================================================================================================
              <S>                                                                                    <C>
              Currently                                                                              1,000,000
              1999                                                                                     200,000

- -----------------------------------------------------------------------------------------------------------------------
                                                                                                     1,200,000
=======================================================================================================================

</TABLE>


         (ii)   These options are effective and exercisable as follows:



<TABLE>
=======================================================================================================================
              <S>                                                                                       <C>
              Currently                                                                                 12,000
              1999                                                                                      12,000
              2000                                                                                      12,000

- -----------------------------------------------------------------------------------------------------------------------
                                                                                                        36,000
=======================================================================================================================
</TABLE>


          (iii) These options become vested at various dates over the next five
                years. During the year, the board of directors approved an
                amendment to change the exercise price of these options to
                $10.00/share. The exercise price was previously set at the
                trading price of the shares on the date preceding each vesting
                date. These options vest as follows:


<TABLE>
=======================================================================================================================
              <S>                                                                                        <C>
              Vested 1998                                                                               50,000
              1999                                                                                      90,000
              2000                                                                                      90,000
              2001                                                                                      50,000
              2002                                                                                      10,000

- -----------------------------------------------------------------------------------------------------------------------
                                                                                                       290,000
- -=======================================================================================================================
</TABLE>


                                      F-15


<PAGE>   75


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

================================================================================
7.   COMMITMENTS:

     (a)  Operating leases:

          Minimum lease payments under operating leases for the Corporation's
          premises for the next three years are as follows:

<TABLE>
================================================================================
     <S>                                                                <C>
     1999                                                               $445,407
     2000                                                                151,582
     2001                                                                 24,089
- --------------------------------------------------------------------------------
                                                                        $621,078
================================================================================
</TABLE>

     (b) Research funding:

         The Corporation is committed to make research grants to an unrelated
         medical facility in the U.S. in the aggregate amount of approximately
         $735,000 (US$516,000) in the next three years as follows:

<TABLE>
================================================================================
     <S>                                                                <C>
     1999                                                               $245,000
     2000                                                                245,000
     2001                                                                245,000
- --------------------------------------------------------------------------------
                                                                        $735,000
================================================================================
</TABLE>


          The Corporation has an exclusive license to patents from this facility
          covering rights to AD7C diagnostics and therapeutics. Under this
          license, the medical facility benefits from research funding and
          collaboration from the Corporation and is entitled to royalties of 4%
          on worldwide sales of the AD7C test.

          During the period ended December 31, 1998, an amount of approximately
          US$128,000 (1997 - US$172,000) was paid and expensed in connection
          with the research grant described above.


                                      F-16


<PAGE>   76


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


7.   COMMITMENTS (CONTINUED):

     (c)  License agreements:

          In January 1999, the Corporation granted a non-exclusive license to an
          American corporation to utilize all proprietory technology, including
          its rights to patents and know-how, necessary to conduct the AD7C test
          in a reference laboratory. The Corporation will receive compensation
          under the agreement based on the number of tests conducted by the
          American company. The license, which is for the US territory, is for
          an initial term of 24 months and is subject to automatic renewal for
          two additional one-year terms.

8.   INCOME TAXES:

     Details of the components of income taxes are as follows:

<TABLE>
<CAPTION>
================================================================================================
                                                      1998             1997              1996
- ------------------------------------------------------------------------------------------------
     <S>                                           <C>              <C>              <C>
     Loss before income taxes:
         Canadian operations                       $(2,573,106)     $(2,489,752)     $(3,106,405)
         U.S. operations                            (4,330,505)      (2,509,703)        (620,659)
- ------------------------------------------------------------------------------------------------
                                                    (6,903,611)      (4,999,455)      (3,727,064)

     Basic income tax rate                                38.0%            38.0%            38.0%
- ------------------------------------------------------------------------------------------------
     Income tax recovery at statutory rates          2,623,000        1,900,000        1,416,000

     Adjustments in income taxes resulting from:
         Non-recognition of losses and other
           unclaimed deductions                     (2,623,000)      (1,900,000)      (1,416,000)
         Credit for losses                                  --               --           28,000
- ------------------------------------------------------------------------------------------------
     Income taxes                                  $        --      $        --      $    28,000
================================================================================================
</TABLE>

                                      F-17




<PAGE>   77


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


8.   INCOME TAXES (CONTINUED):

     The Corporation has non-capital losses carried forward and accumulated
     scientific research and development expenditures which are available to
     reduce future years' taxable income. The related income tax benefit of
     these items will be recorded in earnings when realized. These expire as
     follows:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                               Federal               Provincial
- -----------------------------------------------------------------------------------------------------------------------

     <S>                                                                      <C>                   <C>
     Non-capital losses:
         1999                                                                 $    40,000           $       -
         2000                                                                      36,000               36,000
         2001                                                                      58,000               58,000
         2002                                                                     920,000                   -
         2003                                                                   1,990,000            1,276,000
         2004                                                                   1,388,000            1,090,000
         2005                                                                   3,024,000            3,024,000

     Scientific research and development expenditures:
         (Indefinitely)                                                         1,671,000            4,200,000

=======================================================================================================================
</TABLE>


     The Corporation also has investment tax credits available in the amount of
     approximately $464,000 available to reduce future years' federal taxes
     payable. The benefit of these credits will be recorded when realized. These
     credits expire as follows:


<TABLE>

=======================================================================================================================
     <S>                                                                                              <C>
     2005                                                                                             $ 26,000
     2006                                                                                              290,000
     2007                                                                                              148,000
=======================================================================================================================
</TABLE>


     In addition, the Corporation's US subsidiary has losses carried forward of
     approximately US$4,900,000 which expire as follows:


<TABLE>
=======================================================================================================================
     <S>                                                                                            <C>
     2011                                                                                           $  460,000
     2012                                                                                            1,730,000
     2018                                                                                            2,710,000
=======================================================================================================================
</TABLE>


                                      F-18

<PAGE>   78


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


9.   FINANCIAL INSTRUMENTS:

     (a)  Foreign currency risk management:

          A substantial portion of the Corporation's expenses are derived in US
          dollars. This results in financial risk due to fluctuations in the
          value of the Canadian dollar relative to those foreign currencies. For
          the most part, this exposure is reduced to the extent that the
          Corporation generates revenues in US dollars. Fluctuations in payments
          made for the Corporation's expenses could cause unanticipated
          fluctuations in the Corporation's operating results.

     (b)  Credit risk:

          Financial instruments that potentially subject the Corporation to
          significant concentrations of credit risk consist principally of
          short-term investments. The Corporation has investment policies that
          require placement of short-term investments in financial institutions
          evaluated as highly creditworthy.

     (c)  Fair value disclosure:

          The Corporation has determined that the carrying value of its
          short-term financial assets and liabilities, including cash and
          short-term investments, accrued interest, accounts receivable,
          subscriptions receivable, notes receivables and accounts payable and
          accrued liabilities, approximates fair value due to the immediate or
          short-term maturity of these financial instruments.


                                      F-19
<PAGE>   79


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


10.  CANADIAN/U.S. REPORTING DIFFERENCES:

     (a)  Consolidated statements of earnings:

          The reconciliation of earnings reported in accordance with Canadian
          GAAP and with U.S. GAAP is as follows:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                1998               1997              1996
- -----------------------------------------------------------------------------------------------------------------------

         <S>                                              <C>               <C>                  <C>
         Net loss, Canadian GAAP                          $(6,903,611)      $(4,999,455)         $(3,699,064)

         Adjustments:
              Amortization of patents (i)                     (75,077)          (49,533)             (39,166)
              Stock-based compensation - options
                granted to non-employees (ii)                (406,500)         (150,000)            (592,000)

- -----------------------------------------------------------------------------------------------------------------------
         Net loss, U.S. GAAP                              $(7,385,188)      $(5,198,988)         $(4,330,230)
=======================================================================================================================

- -----------------------------------------------------------------------------------------------------------------------
         Loss per share, U.S. GAAP                        $     (0.38)      $     (0.28)         $     (0.25)
=======================================================================================================================
</TABLE>


     (b)  Consolidated shareholders' equity:

          The reconciliation of shareholders' equity reported in accordance with
          Canadian GAAP and with U.S. GAAP is as follows:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                1998                1997              1996
- -----------------------------------------------------------------------------------------------------------------------

         <S>                                              <C>               <C>                  <C>
         Shareholders' equity, Canadian GAAP              $5,321,780        $3,653,467           $3,829,981

         Adjustments:
              Amortization of patents (i):
                  Cumulative effect to beginning
                    of the period                           (180,139)         (130,606)             (91,440)
                  Current period                             (75,077)          (49,533)             (39,166)
              Stock-based compensation - options
                granted to non-employees (ii):
                  Accumulative effect to beginning
                    of period                               (742,000)         (592,000)                  -
                  Current period                            (406,500)         (150,000)            (592,000)
- -----------------------------------------------------------------------------------------------------------------------
              Increase in deficit                         (1,403,716)         (922,139)            (722,606)
- -----------------------------------------------------------------------------------------------------------------------
         Shareholders' equity, U.S. GAAP                  $3,918,064        $2,731,328           $3,107,375
=======================================================================================================================
</TABLE>


                                      F-20

<PAGE>   80


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------

10.  CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (b)  Consolidated shareholders' equity (continued):

          (i)  In accordance with APB Opinion 17, Intangible Assets, the patents
               are amortized using the straight-line method over 17 years, the
               legal life of the patents, from the date the patent was secured.

          (ii) In accordance with FAS 123, Accounting for Stock-Based
               Compensation, compensation related to the stock options granted
               to non-employees has been recorded in the accounts based on the
               fair value of the stock options at the grant date. The fair value
               of the stock options was estimated as described in note 10 (c)
               (3).

     (c)  Other disclosures required by United States GAAP:

          (1)  Development stage company:

               The Corporation is in the process of developing unique patented
               products which are subject to approval of regulatory authorities.
               The Corporation has completed the research and discovery phase of
               its Alzheimer's diagnostic AD7C test and is currently offering
               testing services in their CLIA certified clinical reference
               laboratory. It has had limited revenues to date on the sale of
               its products under development. Accordingly, the Corporation is a
               development stage company as defined in Statement of Financial
               Accounting Standards No. 7 and the following disclosures are
               required:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                               Cumulative           Cumulative
                                                                        since the date of    since the date of
                                                                             inception of         inception of
                                                                          the Corporation      the Corporation
                                                                          to December 31,      to December 31,
                                                                                     1998                 1997
- -----------------------------------------------------------------------------------------------------------------------

<S>                                                                         <C>                  <C>
              Interest revenue                                              $     547,040        $     303,466

              Service fees                                                        175,847               24,584

              Gross research and development expenditures                       9,126,991            6,107,976

              Other expenses                                                    9,888,251            5,527,963

              Cash inflow (outflow):
                  Operating activities                                        (17,922,963)         (10,672,962)
                  Investing activities                                         (2,439,525)          (1,658,462)
                  Financing activities                                         23,190,693           14,618,769
=======================================================================================================================
</TABLE>


                                      F-21

<PAGE>   81


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------
10.  CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (c) Other disclosures required by United States GAAP (continued):

         (1)   Development stage company (continued):

               The statement of shareholders' equity since date of inception is
               presented below.

<TABLE>
<CAPTION>
=============================================================================================================
                                                                 CONSIDERATION
                                                              ------------------     Accumulated
                                              Shares          Cash         Other       deficit         Total
- -------------------------------------------------------------------------------------------------------------

              <S>                          <C>             <C>          <C>       <C>             <C>
              Year ended July 31, 1990:
                  Common shares issued      2,500,000     $ 200,000    $   --      $        --    $   200,000
                  Net loss                         --            --        --         (126,719)      (126,719)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1990    2,500,000       200,000        --         (126,719)        73,281

              Year ended July 31, 1991:
                  Net loss                         --            --        --          (24,827)       (24,827)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1991    2,500,000       200,000        --          (151,546)       48,454

              Year ended July 31, 1992:
                  Common shares issued          9,375        37,500        --               --         37,500
                  Net loss                         --            --        --          (53,112)       (53,112)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1992    2,509,375       237,500        --         (204,658)        32,842

              Year ended July 31, 1993:
                  Common shares issued        201,250       205,000        --               --        205,000
                  Common shares cancelled    (500,000)           --        --               --             --
                  Net loss                         --            --        --          (48,862)       (48,862)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1993    2,210,625       442,500        --          (253,520)      188,980

              Year ended July 31, 1994:
                  Common shares issued          2,500        10,000        --                --        10,000
                  Net loss                         --            --        --          (71,668)       (71,668)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1994    2,213,125       452,500        --         (325,188)       127,312

              Year ended July 31, 1995:
                  Common shares issued         78,078       412,870        --               --        412,870
                  Net loss                         --            --        --         (393,841)      (393,841)
- -------------------------------------------------------------------------------------------------------------
                  Balance, July 31, 1995    2,291,203       865,370        --         (719,029)       146,341

              Period ended December 31, 1995:
                  Adjustment necessary to
                    increase the number of
                    common shares          12,708,797            --        --               --             --
- -------------------------------------------------------------------------------------------------------------
                  Adjusted number of
                    common shares          15,000,000       865,370           --      (719,029)       146,341
                  Common shares issued      2,047,082     3,157,271      936,894            --      4,094,165
                  Net loss                         --            --           --    (1,639,194)    (1,639,194)
                  Share issue costs                --      (209,797)          --            --       (209,797)
- -------------------------------------------------------------------------------------------------------------
                  Balance,
                    December 31, 1995      17,047,082     3,812,844      936,894     (2,358,223)    2,391,515

              Year ended December 31, 1996:
                  Common shares issued        882,300     5,280,050           --             --     5,280,050
                  Net loss                         --            --           --     (4,330,230)   (4,330,230)
                  Share issue costs                --     (233,960)           --             --      (233,960)
- -------------------------------------------------------------------------------------------------------------
              Balance December 31, 1996
                carried forward            17,929,382     8,858,934      936,894     (6,688,453)    3,107,375
=============================================================================================================
</TABLE>

                                      F-22



<PAGE>   82


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------

10.  CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (c) Other disclosures required by United States GAAP (continued):

         (1)  Development stage company (continued):

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                 Consideration
                                                              ------------------     Accumulated
                                              Shares          Cash         Other       deficit          Total
- -----------------------------------------------------------------------------------------------------------------------

<S>                                          <C>             <C>              <C>       <C>              <C>
              Balance December 31, 1996
                brought forward            17,929,382     $8,858,934   $ 936,894    $(6,688,453)   $ 3,107,375

              Year ended December 31, 1997:
                  Common shares issued        703,491     4,549,941           -              -       4,549,941
                  Net loss                                        -           -      (5,198,988)    (5,198,988)
                  Share issue costs                -       (231,000)          -              -        (231,000)
                  Capital stock subscription       -        504,000           -              -         504,000
- -----------------------------------------------------------------------------------------------------------------------
              Balance, December 31, 1997   18,632,873    13,681,875      936,894    (11,887,441)     2,731,328

              Year ended December 31, 1998:
                  Common shares issued      1,095,031     8,654,924           -              -       8,654,924
                  Net loss                         -             -            -      (7,385,188)    (7,385,188)
                  Share issue costs                -        (83,000)          -              -         (83,000)
- -----------------------------------------------------------------------------------------------------------------------
              Balance, December 31, 1998   19,727,904   $22,253,799    $ 936,894   $(19,272,629)   $ 3,918,064
=======================================================================================================================

</TABLE>


         (2)  Income taxes:

              In accordance with Statement of Financial Accounting Standards
              No. 109,  the income tax effect of temporary differences that give
              rise to the net deferred tax asset are presented below:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                                     1998               1997
- -----------------------------------------------------------------------------------------------------------------------

<S>                                                                         <C>                  <C>
              Scientific research and experimental development              $     860,000        $   1,100,000

              Non-capital losses                                                2,600,000            1,594,000

              Investment tax credits                                              464,000              590,000

              Share issue costs                                                   162,000              196,000

              Less valuation allowance                                         (4,086,000)          (3,480,000)

- -----------------------------------------------------------------------------------------------------------------------
              Net deferred tax asset                                        $          -         $          -
=======================================================================================================================
</TABLE>


              There are no material deferred tax liabilities.


                                      F-23
<PAGE>   83


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------

10.  CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (c) Other disclosures required by United States GAAP (continued):

         (2)   Income taxes (continued):

               In assessing the realizability of deferred tax assets, management
               considers whether it is more likely than not that some portion or
               all of the deferred tax assets will not be realized. The ultimate
               realization of deferred tax assets is dependent upon the
               generation of future taxable income and tax planning strategies.
               Since the Corporation is a development stage enterprise, the
               generation of future taxable income is dependent on the
               successful commercialization of its products and technologies.

         (3)   Stock-based compensation:

               The Corporation applies APB Opinion 25, Accounting for Stock
               Issued to Employees, in accounting for its stock option plan, and
               accordingly, no compensation cost has been recognized for its
               stock options in the financial statements. Had compensation cost
               for the Corporation's stock option plan been determined based on
               the fair value at the grant dates for awards under the plan
               consistent with the method of FASB Statement 123, Accounting for
               Stock-Based Compensation, the Corporation's net earnings and loss
               per share would have been adjusted to the pro-forma amounts
               indicated below for US GAAP:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                                       1998               1997
- -----------------------------------------------------------------------------------------------------------------------
<S>                                         <C>               <C>                  <C>                <C>
              Net loss                      As reported       (US GAAP)      $    (7,385,188)   $   (5,198,988)
                                            Pro-forma                             (7,385,188)       (5,990,365)

              Loss per share                As reported       (US GAAP)                (0.38)            (0.28)
                                            Pro-forma                                  (0.38)            (0.33)
=======================================================================================================================
</TABLE>

               The fair value of each option grant was estimated on the date of
               grant using the Black-Scholes option-pricing model with the
               following weighted-average assumptions: risk-free interest rate
               of 5%, dividend yield of 0%, expected volatility of 50%, and
               expected life of 5 years.

         (4)   Short-term investments:

               Short-term investments are classified as held-to-maturity as the
               Corporation has the positive intent and ability to hold these
               securities to maturity. As the Corporation's short-term
               investments include government securities and commercial paper,
               the aggregate fair value approximates carrying value and there
               are no significant unrealized gross holding gains or losses.


                                      F-24
<PAGE>   84


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------

10.  CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (c)  Other disclosures required by United States GAAP (continued):

          (5)  Comprehensive income:

               Effective January 1, 1998, the Corporation adopted Statement of
               Financial Accounting Standards No. 130, Reporting Comprehensive
               Income, which establishes new rules for the reporting and display
               of comprehensive income and its components. The adoption of this
               statement has no impact on the Corporation's net income or
               shareholders' equity.

11.  SEGMENT DISCLOSURES:

     Geographic segment information was as follows:

<TABLE>
<CAPTION>
=======================================================================================================================
                                                                                                        United
                                                                                   Canada               States
                                                                                   ------               ------
<S>                                                                                <C>                  <C>
     Revenues:
         1998                                                               $     243,574        $     151,263
         1997                                                                      76,526               24,584
         1996                                                                     226,940                   -

     Net loss:
         1998                                                                  (2,573,106)          (4,330,505)
         1997                                                                  (2,489,752)          (2,509,703)
         1996                                                                  (3,106,405)            (620,659)

     Identifiable assets:
         1998                                                                   4,940,335              815,885
         1997                                                                   3,579,849              365,948
=======================================================================================================================
</TABLE>


12.  UNCERTAINTY DUE TO THE YEAR 2000 ISSUE:

     The Year 2000 Issue arises because many computerized systems use two digits
     rather than four to identify a year. Date-sensitive systems may recognize
     the year 2000 as 1900 or some other date, resulting in errors when
     information using year 2000 dates is processed. In addition, similar
     problems may arise in some systems which use certain dates in 1999 to
     represent something other than a date. The effects of the Year 2000 Issue
     may be experienced before, on, or after January 1, 2000, and, if not
     addressed, the impact on operations and financial reporting may range from
     minor errors to significant systems failure which could affect an entity's
     ability to conduct normal business operations. It is not possible to be
     certain that all aspects of the Year 2000 Issue affecting the entity,
     including those related to the efforts of customers, suppliers, or other
     third parties, will be fully resolved.


                                      F-25
<PAGE>   85


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued

Years ended December 31, 1998, 1997 and 1996
(in Canadian dollars)

- --------------------------------------------------------------------------------


13.  SUBSEQUENT EVENT:

     In January 1999, the Corporation completed private placements for a total
     of 55,000 common shares at $8.50 per share, and received gross proceeds of
     $467,500. In connection with these private placements, the Corporation
     issued an additional 27,500 Series D warrants exercisable at a price of
     $10.00 per share, expiring on December 31, 1999.


                                      F-26
<PAGE>   86








                      Consolidated Financial Statements of
                                  (Unaudited)

                              NYMOX PHARMACEUTICAL

                                  CORPORATION

                   Periods ended September 30, 1999 and 1998


                                      F-27



<PAGE>   87


NYMOX PHARMACEUTICAL CORPORATION
Consolidated Financial Statements
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997

<TABLE>
<S>                                                                                       <C>
     FINANCIAL STATEMENTS

     Consolidated Balance Sheets.......................................................   F-29

     Consolidated Statements of Earnings...............................................   F-30

     Consolidated Statements of Deficit................................................   F-31

     Consolidated Statements of Cash Flows.............................................   F-32

     Notes to Consolidated Financial Statements........................................   F-33
</TABLE>


                                      F-28



<PAGE>   88




NYMOX PHARMACEUTICAL CORPORATION
Consolidated Balance Sheets
(Unaudited)

September 30, 1999 and 1998, with comparative figures as at December 31, 1998
(in Canadian dollars)

<TABLE>
<CAPTION>

=======================================================================================================================
                                                        September 30,       September 30,         December 31,
                                                                 1999                1998                 1998
- -----------------------------------------------------------------------------------------------------------------------
                                                          (Unaudited)         (Unaudited)            (Audited)

<S>                                                   <C>                  <C>                  <C>
Assets

Current assets:

     Cash                                             $      663,415       $      837,253       $      714,298
     Short-term investments                                   262,350           2,942,572            2,113,907
     Accrued interest                                          22,641             119,262               46,082
     Receivable from a financial institution                  410,000                  -               637,500
     Accounts receivable                                       60,822              56,042               74,653
     Notes receivable                                         265,075             278,024              273,995
     Research tax credits receivable                           24,923               5,347                5,778
     Other receivables                                             -               26,000               43,028
     Prepaid expenses                                         146,740                  -                    -
- -----------------------------------------------------------------------------------------------------------------------
                                                            1,855,966           4,264,500            3,909,241

Capital assets                                              1,610,772           1,606,675            1,846,979

- -----------------------------------------------------------------------------------------------------------------------
                                                        $   3,466,738      $    5,871,175       $    5,756,220
- -----------------------------------------------------------------------------------------------------------------------

Liabilities and Shareholders' Equity

Current liabilities:

     Accounts payable and accrued liabilities         $      275,667       $       89,166       $      434,440

Shareholders' equity:

     Capital stock                                         24,410,480          21,831,103           23,011,556
     Deficit                                              (21,219,409)        (16,049,094)         (17,689,776)
- -----------------------------------------------------------------------------------------------------------------------
                                                            3,191,071           5,782,009            5,321,780

- -----------------------------------------------------------------------------------------------------------------------
                                                         $  3,466,738      $    5,871,175      $     5,756,220
=======================================================================================================================
</TABLE>


See accompanying notes to unaudited consolidated financial statements.


                                      F-29



<PAGE>   89


NYMOX PHARMACEUTICAL CORPORATION

Consolidated Statements of Earnings
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

<TABLE>
<CAPTION>
=======================================================================================================================
                                   Three Months Ended September 30,          Nine Months Ended September 30,
- -----------------------------------------------------------------------------------------------------------------------
                                       1999        1998          1997         1999         1998         1997
- -----------------------------------------------------------------------------------------------------------------------

<S>                              <C>           <C>          <C>          <C>          <C>          <C>
Revenues:

     Service fees                $    27,004   $    26,762  $        -   $   178,496  $    60,135  $    18,927
     Interest                         16,524        88,838       25,386       42,416      187,464       46,855
- -----------------------------------------------------------------------------------------------------------------------
                                      43,528       115,600       25,386      220,912      247,599       65,782

Expenses:

     Research and development        389,693       924,641    1,026,682    1,241,011    2,198,823    2,039,761
     Less investment tax credits     (17,279)      (13,315)     (46,500)     (19,145)     (18,662)    (144,500)
- -----------------------------------------------------------------------------------------------------------------------
                                     372,414       911,326      980,182    1,221,866    2,180,161    1,895,261
     General, administrative and
       cost of sales                 529,692       133,988       77,645    1,305,242      608,894      470,783
     Marketing                       293,326       902,597      370,512    1,057,545    2,570,594    1,442,639
     Depreciation and amortization    71,013        41,659       40,834      168,138      128,230      119,781
     Interest and bank charges        11,351        18,073        5,310       14,558       22,649       11,070
- -----------------------------------------------------------------------------------------------------------------------
                                   1,277,796     2,007,643    1,474,483    3,767,349    5,510,528    3,939,534

Gain on disposal of capital assets        -             -            -       (67,379)          -            -

- -----------------------------------------------------------------------------------------------------------------------
Net loss                         $(1,234,268)  $(1,892,043) $(1,449,097) $(3,479,058) $(5,262,929) $(3,873,752)
=======================================================================================================================

- -----------------------------------------------------------------------------------------------------------------------
Loss per share                   $     (0.06)  $     (0.10) $     (0.08) $     (0.17) $     (0.27) $     (0.21)
=======================================================================================================================

- -----------------------------------------------------------------------------------------------------------------------
Weighted average number of
   common shares outstanding     19,932,804     19,592,274   18,631,783   19,847,612   19,239,411   18,234,967
=======================================================================================================================
</TABLE>


See accompanying notes to unaudited consolidated financial statements.


                                      F-30




<PAGE>   90


NYMOX PHARMACEUTICAL CORPORATION

Consolidated Statements of Deficit
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

<TABLE>
<CAPTION>
=======================================================================================================================
                                  Three Months Ended September 30,           Nine Months Ended September 30,
- -----------------------------------------------------------------------------------------------------------------------
                                  1999           1998         1997          1999          1998            1997
- -----------------------------------------------------------------------------------------------------------------------

<S>                       <C>            <C>           <C>          <C>           <C>              <C>
Deficit, beginning of
   period                 $(19,985,141)  $(14,157,051) $(8,007,365) $(17,689,776) $(10,703,165)    $(5,472,710)

Net loss                    (1,234,268)    (1,892,043)  (1,449,097)   (3,479,058)   (5,262,929)     (3,873,752)

Share issue costs                    -              -     (121,000)      (50,575)      (83,000)       (231,000)

- -----------------------------------------------------------------------------------------------------------------------
Deficit, end of period    $(21,219,409)  $(16,049,094) $(9,577,462) $(21,219,409) $(16,049,094)    $(9,577,462)
=======================================================================================================================
</TABLE>


See accompanying notes to unaudited consolidated financial statements.


                                      F-31



<PAGE>   91


NYMOX PHARMACEUTICAL CORPORATION
Consolidated Statements of Cash Flows
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

<TABLE>
<CAPTION>
=======================================================================================================================
                                   Three Months Ended September 30,             Nine Months Ended September 30,
- -----------------------------------------------------------------------------------------------------------------------
                                       1999        1998        1997              1999         1998         1997
- -----------------------------------------------------------------------------------------------------------------------

<S>                              <C>           <C>          <C>                <C>          <C>          <C>

Cash flows from operating activities:
     Net loss                    $(1,234,268)  $(1,892,043) $(1,449,097)       $(3,479,058) $(5,262,929) $(3,873,752)
     Items not involving cash:
         Depreciation and
           amortization               71,013        41,659       40,834            168,138      128,230      119,781
         Gain on disposal of
           capital assets                 -             -            -             (67,379)          -            -
     Net change in non-cash
       operating working
       capital items                (197,982)     (156,387)    (119,645)            (7,938)    (447,270)    (286,320)
- -----------------------------------------------------------------------------------------------------------------------
                                  (1,361,237)   (2,006,771)  (1,527,908)        (3,386,237)  (5,581,969)  (4,040,291)

Cash flows from financing activities:

     Issuance of capital stock       642,499            -            -           1,398,924    7,474,471    4,549,463
     Share issue costs                    -             -      (121,000)           (50,575)     (83,000)    (231,000)
- -----------------------------------------------------------------------------------------------------------------------
                                     642,499            -      (121,000)         1,348,349    7,391,471    4,318,463

Cash flows from investing activities:

     Additions to capital assets     (87,278)      (90,359)     (41,119)          (137,457)    (317,022)    (256,155)
     Proceeds on disposal of capital
       assets                             -            -             -             272,905           -            -
- -----------------------------------------------------------------------------------------------------------------------
                                     (87,278)      (90,359)     (41,119)           135,448     (317,022)    (256,155)
- -----------------------------------------------------------------------------------------------------------------------
(Decrease) increase in cash  and
   short-term investments           (806,016)   (2,097,130)  (1,690,027)        (1,902,440)   1,492,480       22,017

Cash and short-term investments,
   beginning of period             1,731,781     5,876,955    4,218,971          2,828,205    2,287,345    2,506,927
- -----------------------------------------------------------------------------------------------------------------------
Cash and short-term investments,
   end of period                 $   925,765   $ 3,779,825  $ 2,528,944        $   925,765  $ 3,779,825  $ 2,528,944
=======================================================================================================================
Supplemental disclosure to
   statement of cash flows:

     Income taxes paid           $        -    $        -   $        -         $        -   $        -   $        -
     Interest paid                    11,351        18,073        5,310             14,558       22,649       11,070
=======================================================================================================================
</TABLE>


See accompanying notes to unaudited consolidated financial statements.


                                      F-32



<PAGE>   92


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

- --------------------------------------------------------------------------------

     Nymox Pharmaceutical Corporation (the "Corporation"), incorporated under
     the Canada Business Corporations Act, is a development stage
     biopharmaceutical corporation which specializes in the research and
     development of neurological therapeutics and diagnostics for the aging
     population, with an emphasis on Alzheimer's disease.

     Since inception, the Corporation's activities have been primarily focused
     on developing certain pharmaceutical technologies and obtaining outside
     funding to support the continued development of its technologies. The
     Corporation is subject to a number of risks, including the successful
     development and marketing of its technologies. In order to achieve its
     business plan, the Corporation anticipates the need to raise additional
     capital.

     The Corporation is listed on the Montreal Exchange and on the NASDAQ Stock
     Market.

1.   BASIS OF PRESENTATION:

     (a)  Consolidation:

          The consolidated financial statements of the Corporation have been
          prepared under Canadian generally accepted accounting principles and
          include the accounts of its wholly-owned US subsidiary. Significant
          intercompany balances and transactions have been eliminated on
          consolidation.

     (b)  Interim financial statements:

          The unaudited consolidated balance sheets as at September 30, 1999 and
          1998, and the unaudited consolidated statements of earnings and
          deficit and cash flows for the periods ended September 30, 1999, 1998
          and 1997 reflect all adjustments which are, in the opinion of
          management, necessary to a fair statement of the results of the
          interim periods presented. There are no adjustments in these interim
          financial statements other than normal recurring adjustments.


                                      F-33
<PAGE>   93


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

- --------------------------------------------------------------------------------


2.   CANADIAN/U.S. REPORTING DIFFERENCES:

     (a)  Consolidated statements of earnings:

          The reconciliation of earnings reported in accordance with Canadian
          GAAP with U.S. GAAP is as follows:

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------
                                     Three Months Ended September 30,        Nine Months Ended September 30,
- -----------------------------------------------------------------------------------------------------------------------
                                     1999          1998          1997         1999         1998         1997
- -----------------------------------------------------------------------------------------------------------------------

        <S>                        <C>             <C>          <C>          <C>          <C>          <C>
         Net loss, Canadian
         GAAP                      $(1,234,268)    $(1,892,043) $(1,449,097) $(3,479,058) $(5,262,929) $(3,873,752)

         Adjustments:
              Amortization of
              patents                  (26,066)        (16,429)     (12,322)     (72,082)     (46,418)     (36,967)

- -----------------------------------------------------------------------------------------------------------------------
         Net loss, U.S. GAAP       $(1,260,334)    $(1,908,472) $(1,461,419) $(3,551,140) $(5,309,347)  $(3,910,719)
- -----------------------------------------------------------------------------------------------------------------------


- -----------------------------------------------------------------------------------------------------------------------
         Loss per share,
           U.S. GAAP               $     (0.06)    $     (0.10) $     (0.08) $     (0.18) $     (0.28)  $     (0.21)
- -----------------------------------------------------------------------------------------------------------------------
</TABLE>


                                      F-34




<PAGE>   94


NYMOX PHARMACEUTICAL CORPORATION
Notes to Consolidated Financial Statements, Continued
(Unaudited)

Periods ended September 30, 1999, 1998 and 1997
(in Canadian dollars)

- --------------------------------------------------------------------------------


2.   CANADIAN/U.S. REPORTING DIFFERENCES (CONTINUED):

     (b)  Consolidated shareholders' equity:

          The reconciliation of shareholders' equity reported in accordance with
          Canadian GAAP with U.S. GAAP is as follows:

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------
                                                                    September 30,                 December 31,
- -----------------------------------------------------------------------------------------------------------------------
                                                                    1999             1998                 1998
- -----------------------------------------------------------------------------------------------------------------------

<S>                                                        <C>              <C>                  <C>
         Shareholders' equity, Canadian GAAP               $   3,191,071    $   5,782,009        $   5,321,780

         Adjustments:

              (i) Amortization of patents:

                  Cumulative effect to beginning of the period  (255,216)        (180,139)            (180,139)
                  Current period                                 (72,082)         (46,418)             (75,077)
- -----------------------------------------------------------------------------------------------------------------------
                                                                (327,298)        (226,557)            (255,216)

               (ii) Stock-based compensation:

                  Cumulative effect to beginning of period    (1,148,500)        (742,000)            (742,000)
                  Current period                                      -                -              (406,500)
- -----------------------------------------------------------------------------------------------------------------------
                                                              (1,148,500)        (742,000)          (1,148,500)

- -----------------------------------------------------------------------------------------------------------------------
              Increase in deficit                             (1,475,798)        (968,557)          (1,403,716)

- -----------------------------------------------------------------------------------------------------------------------
         Shareholders' equity, U.S. GAAP                   $   1,715,273    $   4,813,452        $   3,918,064
</TABLE>

3.   SEGMENT DISCLOSURES:

     Geographic segment information was as follows:

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------
                                                                                                        United
                                                                                   Canada               States
- -----------------------------------------------------------------------------------------------------------------------

<S>                                                                          <C>                  <C>
     Revenues:

         1999                                                               $      42,416        $     178,496
         1998                                                                     187,464               60,135
         1997                                                                      46,855               18,927

     Net loss:

         1999                                                                  (2,597,630)            (881,428)
         1998                                                                  (1,958,719)          (3,304,210)
         1997                                                                  (2,049,373)          (1,824,379)

     Identifiable assets:

         September 30, 1999                                                     2,900,575              566,163
         September 30, 1998                                                     5,160,095              711,080
         December 31, 1998                                                      4,940,335              815,885
- -----------------------------------------------------------------------------------------------------------------------
</TABLE>


                                      F-35





<PAGE>   95



<TABLE>

<S>                                                                                       <C>
NO DEALER, SALESPERSON OR OTHER PERSON HAS BEEN AUTHORIZED IN                             ________________________
CONNECTION WITH THIS OFFERING TO GIVE ANY INFORMATION OR TO MAKE
ANY REPRESENTATIONS OTHER THAN THOSE CONTAINED IN THIS PROSPECTUS.                         5,000,000 Common Shares
THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER OR A SOLICITATION
IN ANY JURISDICTION TO ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE                                 offered by
SUCH AN OFFER OR SOLICITATION. NEITHER THE DELIVERY OF THIS
PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL, UNDER ANY                                    Jaspas Investments Ltd.
CIRCUMSTANCES, CREATE AN IMPLICATION THAT THERE HAS BEEN NO                               ________________________
CHANGE IN THE CIRCUMSTANCES OF NYMOX OR THE FACTS HEREIN SET
FORTH SINCE THE DATE HEREOF.

     _________________________________________________

</TABLE>

<TABLE>
<CAPTION>
                                                                                                   NYMOX

                                                                                               PHARMACEUTICAL

                        TABLE OF CONTENTS                                                       CORPORATION

                                                          PAGE

<S>                                                        <C>                            <C>

Note About Currency........................................  2
The Company................................................  3
Cautionary Statement Regarding Forward-looking
Statements.................................................  5                           ________________________
Risk Factors...............................................  6
Trading Market for Common Shares........................... 11                              P R O S P E C T U S
Selected Consolidated Financial Data....................... 11                           ________________________
Information about the Company.............................. 13
Management's Discussion and Analysis of Results
of Operations and Financial Condition...................... 20
Recent Developments........................................ 25
Use of Proceeds............................................ 28
The Common Stock Purchase Agreement........................ 29
Selling Security Holder.................................... 37
Directors and Officers of Nymox............................ 38                            _________________ , 1999
Compensation............................................... 39
Options.................................................... 40
Interest of Management in Certain Transactions............. 43
Controlling Shareholder.................................... 44
Plan of Distribution....................................... 44
Canadian Federal Income Tax Considerations................. 48
U.S. Federal Income Tax Considerations..................... 51
Description of Nymox's Common Shares....................... 54
Certain Legal Matters...................................... 56
Experts.................................................... 56
Where You Can Find More Information........................ 57
Enforcement of Certain Civil Liabilities and
Authorized Representative in the United States............. 57
</TABLE>

<PAGE>   96

                PART II  INFORMATION NOT REQUIRED IN PROSPECTUS

Item 13: Other Expenses of Issuance and Distribution

The following is a list of the estimated expenses to be incurred by the
Registrant in connection with the preparation and filing of this registration
statement.

<TABLE>
<S>                                                                     <C>
SEC Registration Fee                                                    $ 3,406
Legal Fees and Expenses                                                 $30,000
Accountants Fees                                                        $ 5,000
                                                                        -------
TOTAL                                                                   $38,406
</TABLE>


The estimated expenses reflected herein do not include the reimbursement of
$35,000 by Nymox to Jaspas, primarily related to legal fees in preparation of
the stock purchase agreement and associated escrow costs.

Item 14: Indemnification of Directors and Officers

Nymox maintains Directors' and Officers' Liability Insurance (the "Policy") for
its own benefit and for the benefit of its subsidiaries and their respective
directors and officers. Subject to the limitations therein set forth, the Policy
extends coverage to directors and officers for any loss (as defined in the
Policy) incurred in connection with the performance of their duties and to Nymox
and its subsidiaries for any loss for which they have indemnified their
respective directors or officers as permitted by law.

Section 124 of the Canada Business Corporations Act ("CBCA") provides, in
pertinent part:

          124. (1) Indemnification. - Except in respect of an action by or on
          behalf of the corporation or body corporate to procure a judgment in
          its favor, a corporation may indemnify a director or officer of the
          corporation, a former director or officer of the corporation or a
          person who acts or acted at the corporation's request as a director or
          officer of a body corporate of which the corporation is or was a
          shareholder or creditor, and his heirs and legal representatives,
          against all costs, charges and expenses, including an amount paid to
          settle an action or satisfy a judgment, reasonably incurred by him in
          respect of any civil, criminal or administrative action or proceeding
          to which he is made a party by reason of being or having been a
          director or officer of such corporation or body corporate, if,

               (a) he acted honestly and in good faith with a view to the best
               interests of the corporation; and

               {b) in the case of a criminal or administrative action or
               proceeding that is enforced by a monetary penalty, he had
               reasonable grounds for believing that his conduct was lawful.

          (2) Indemnification in derivative actions. - A corporation may, with
          the approval of the court, indemnify a person referred to in
          subsection (1) in respect of an action by or on behalf of the
          corporation or body corporate to procure a judgment in its favor, to
          which he is made a party by reason of being or having been a director
          or an officer of the corporation or body corporate, against all costs,
          charges and expenses reasonably incurred by him in connection with
          such action if he fulfills the conditions set out in clauses (1)(a)
          and (b).


                                      II-1
<PAGE>   97

          (3) Indemnity as of right. - Notwithstanding anything in this section,
          a person referred to in subsection (1) is entitled to indemnify from
          the corporation in respect of all costs, charges and expenses
          reasonably incurred by him in connection with the defense of any
          civil, criminal or administrative action or proceeding to which he is
          made a party by reason of being or having been a director or officer
          of the corporation or body corporate, if the person seeking indemnity,

               (a) was substantially successful on the merits in his defense of
               the action or proceeding; and

               (b) fulfills the conditions set out in clauses (1)(a) and (b).

          (4) Directors' and officers' insurance. - A corporation may purchase
          and maintain insurance for the benefit of any person referred to in
          subsection (1) against any liability incurred by him,

               (a) in his capacity as a director or officer of the corporation,
               except where the liability relates to his failure to act honestly
               and in good faith with a view to the best interests of the
               corporation; or

               (b) in his capacity as a director or officer of another body
               corporate where he acts or acted in that capacity at the
               corporation's request, except where the liability relates to his
               failure to act honestly and in good faith with a view to the best
               interests of the body corporate.

Insofar as indemnification for liabilities arising under the Securities Act of
1933 may be permitted to directors, officers or persons controlling the
Registrant pursuant to the foregoing provisions, the Registrant has been
informed that in the opinion of the United States Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is therefore unenforceable.

Item 15.  Recent Sales of Unregistered Securities

All recent sales of unregistered shares were pursuant to exemptions from
registration under applicable Canadian and Quebec securities laws and were not
made to persons resident in the United States.

     -    April 1996, 877,300 common shares at a per share price of CAN$6.00 for
          aggregate net proceeds of CAN$5,263,800 with Prampton Company Ltd.
          (200,000 shares), Murray Lester Investments (120,000 shares), Gestion
          3B+M Inc. (100,000 shares) and a group of individual Canadian and
          overseas investors (457,300 shares);

     -    May 1997, 696,491 common shares at a price of CAN$6.50 and warrants
          exercisable at a price of CAN$8.50 per share for a total consideration
          of CAN$4,527,191 with the Caisse de Depot et Placement du Quebec
          (307,692 shares), Abrar Corp. (85,538 shares) and a group of
          individual Canadian and overseas investors (303,261 shares). In 1998,
          all 696,491 of these warrants were exercised for additional proceeds
          to Nymox of CAN$5,920,174;


                                      II-2
<PAGE>   98

     -    May 1998, 231,630 common shares at a price of CAN$8.50 for total
          proceeds of CAN$1,968,855 with Dr. Stephan Eschmann (76,500 shares)
          and a group of individual Canadian and overseas investors (155,130
          shares). A total of 110,000 warrants were issued as well, exercisable
          at prices of CAN$8.50 per share (50,000) and CAN$10.00 per share
          (60,000). These warrants have since expired;

     -    January, 1999, 190,000 common shares at CAN$8.50 per share, for total
          proceeds of CAN$1,615,000 with Sparks Inc. (75,000 shares), Dr.
          Stephan Eschmann (70,000 shares), and a group of individual Canadian
          and overseas investors (45,000 shares). A total of 95,000 warrants
          were issued as well, exercisable at the price of CAN$10.00 per share.
          These warrants have since expired; and

     -    September, 1999, 122,000 common shares at CAN$5.00 per share, for
          total proceeds of CAN$610,000 with Dr. Stephan Eschmann (82,000
          shares) and Mr. Michael Braeuel (40,000 shares).

Item 16. Exhibits and Financial Statement Schedules

<TABLE>
<CAPTION>
- ------------------ ------------------------------------------------------------------- ----------------------

Exhibit No.                                   Description

- ------------------ ------------------------------------------------------------------- ----------------------

<S>                 <C>                                                                <C>
       2.0         Common Stock Purchase Agreement between Nymox Pharmaceutical        Filed Herewith
                   Corporation and Jaspas Investments Limited dated November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.1         Registration Rights Agreement between Nymox Pharmaceutical          Filed Herewith
                   Corporation and Jaspas Investments Limited dated November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.2         Escrow Agreement among Nymox Pharmaceutical Corporation, Jaspas     Filed Herewith
                   Investments Limited and Epstein, Becker & Green, P.C. dated
                   November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.3         Stock Purchase Warrant to purchase common shares issued to
                   Jaspas Filed Herewith Investments Limited dated November 1,
                   1999

- ------------------ ------------------------------------------------------------------- ----------------------

       3.0         Articles of Incorporation of Nymox Pharmaceutical Corporation       Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

       3.1         Bylaws of Nymox Pharmaceutical Corporation                          Filed Herewith
- ------------------ ------------------------------------------------------------------- ----------------------

       5.1         Opinion of Foley & Lardner                                          Filed Herewith
- ------------------ ------------------------------------------------------------------- ----------------------

       5.2         Opinion of Stikeman, Elliott                                        Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      10.1         Employment Agreement between Nymox Pharmaceutical Corporation and   Filed Herewith
                   Dr. Judith Fitzpatrick

- ------------------ ------------------------------------------------------------------- ----------------------

      23.1         Consent of KPMG                                                     Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      23.2         Consent of Foley & Lardner                                          Included as part of
                                                                                       Exhibit 5.1
- ------------------ ------------------------------------------------------------------- ----------------------

      23.3         Consent of Stikeman, Elliott                                        Included as part of
                                                                                       Exhibit 5.2
- ------------------ ------------------------------------------------------------------- ----------------------

      24.0         Power of Attorney                                                   Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      27.0         Financial Data Schedule                                             Filed Herewith

      99.0         Press release by Nymox Pharmaceutical Corporation dated             Filed Herewith
                   November 12, 1999 announcing the transaction
                   with Jaspas Investments Limited

- ------------------ ------------------------------------------------------------------- ----------------------
</TABLE>


                                      II-3




<PAGE>   99

Item 17. Undertakings

The undersigned Registrant hereby undertakes:

1.   To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement;

     (i)  To include any prospectus required by section 10(a)(3) of the
          Securities Act of 1933, as amended ("Securities Act").

     (ii) To reflect in the prospectus included in this registration statement
          any facts or events arising after the effective date of this
          registration statement (or the most recent post-effective amendment
          thereof) which, individually or in the aggregate, represent a
          fundamental change in the information set forth in this registration
          statement. Notwithstanding the foregoing, any increase or decrease in
          volume of securities offered (if the total dollar value of securities
          offered would not exceed that which was registered) and any deviation
          from the low or high end of the estimated maximum offering range may
          be reflected in the form of prospectus filed with the Securities and
          Exchange Commission ("SEC") pursuant to Rule 424(b) if, in the
          aggregate, the changes in volume and price represent no more than a
          20% change in the maximum aggregate offering price set forth in the
          "Calculation of Registration Fee" table in the effective registration
          statement; and

    (iii) To include any material information with respect to the plan of
          distribution not previously disclosed in the registration statement or
          any material change to such information in this registration
          statement.

2. To remove from registration by means of a post-effective amendment any of the
securities being registered, which remain unsold at the termination of the
offering.

3. To file a post-effective amendment to this registration statement to include
any financial statements required by Rule 3-19 of Regulation S-X under the
Securities Exchange Act of 1934 throughout the offering.

4. For the purpose of determining any liability under the Securities Act of
1933, each post-effective amendment that contains a form of prospectus shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


                                      II-4
<PAGE>   100

5. Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the provisions described under item 14 above, or
otherwise, the Registrant has been advised that in the opinion of the SEC such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question of whether such indemnification by it is against
public policy as expressed in the Securities Act and will be governed by the
final adjudication of such issue.

                                   SIGNATURES

Pursuant to the requirements of the Securities Act, the Registrant certifies
that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form F-1 and has duly caused this registration statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Montreal, Country of Canada, on February ___________, 2000.

Nymox Pharmaceutical Corporation

By:      /s/ Paul Averback
        --------------------------------------
         Paul Averback, M.D.
         President and Chief Executive Officer
         (Principal Executive Officer)

By:      /s/ Roy Wolvin
         ---------------------------------------
         Roy Wolvin
         Chief Financial Officer and Secretary-Treasurer
         (Principal Financing Officer and Accounting Officer)


                                      II-5



<PAGE>   101


                                 EXHIBIT INDEX

<TABLE>
<CAPTION>
- ------------------ ------------------------------------------------------------------- ----------------------

Exhibit No.                                   Description

- ------------------ ------------------------------------------------------------------- ----------------------

<S>               <C>                                                                 <C>
       2.0         Common Stock Purchase Agreement between Nymox Pharmaceutical        Filed Herewith
                   Corporation and Jaspas Investments Limited dated November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.1         Registration Rights Agreement between Nymox Pharmaceutical          Filed Herewith
                   Corporation and Jaspas Investments Limited dated November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.2         Escrow Agreement among Nymox Pharmaceutical Corporation, Jaspas     Filed Herewith
                   Investments Limited and Epstein, Becker & Green, P.C. dated
                   November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       2.3         Stock Purchase Warrant to purchase common shares issued to          Filed Herewith
                   Jaspas Investments Limited dated November 1, 1999

- ------------------ ------------------------------------------------------------------- ----------------------

       3.0         Articles of Incorporation of Nymox Pharmaceutical Corporation       Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

       3.1         Bylaws of Nymox Pharmaceutical Corporation                          Filed Herewith
- ------------------ ------------------------------------------------------------------- ----------------------

       5.1         Opinion of Foley & Lardner                                          Filed Herewith
- ------------------ ------------------------------------------------------------------- ----------------------

       5.2         Opinion of Stikeman, Elliott                                        Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      10.1         Employment Agreement between Nymox Pharmaceutical Corporation and   Filed Herewith
                   Dr. Judith Fitzpatrick

- ------------------ ------------------------------------------------------------------- ----------------------

      23.1         Consent of KPMG                                                     Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      23.2         Consent of Foley & Lardner                                          Included as part of
                                                                                       Exhibit 5.1
- ------------------ ------------------------------------------------------------------- ----------------------

      23.3         Consent of Stikeman, Elliott                                        Included as part of
                                                                                       Exhibit 5.2
- ------------------ ------------------------------------------------------------------- ----------------------

      24.0         Power of Attorney                                                   Filed Herewith

- ------------------ ------------------------------------------------------------------- ----------------------

      27.0         Financial Data Schedule                                             Filed Herewith

      99.0         Press release by Nymox Pharmaceutical Corporation dated             Filed Herewith
                   November 12, 1999 announcing the transaction with Jaspas
                   Investments Limited

- ------------------ ------------------------------------------------------------------- ----------------------
</TABLE>

                                      II-6




<PAGE>   1


EXHIBIT 2.0

                         COMMON STOCK PURCHASE AGREEMENT

     This COMMON STOCK PURCHASE AGREEMENT (this "Agreement") is dated as of
November 1, 1999 by and between Nymox Pharmaceutical Corporation, a Canada
corporation (the "Company"), and Jaspas Investments Limited (the "Purchaser").

     The parties hereto agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

     Section 1.1  Certain Definitions.

     (a) "Average Daily Price" shall be the price based on the VWAP of the
Company on the Nasdaq SmallCap Market or, if the Nasdaq SmallCap Market is not
the Principal Market, on the Principal Market.

     (b) "Draw Down" shall have the meaning assigned to such term in Section
6.1(a) hereof.

     (c) "Draw Down Exercise Date" shall have the meaning assigned to such term
in Section 6.1(b) hereof.

     (d) "Draw Down Pricing Period" shall mean a period of twenty-two (22)
consecutive Trading Days preceding a Draw Down Exercise Date.

     (e) "Effective Date" shall mean the date the Registration Statement of the
Company covering the Shares being subscribed for hereby is declared effective.

     (f) "Material Adverse Effect" shall mean any adverse effect on the
business, operations, properties or financial condition of the Company that
materially impairs the ability of the Company and its subsidiaries and
affiliates, taken as a whole, to perform any of its material obligations under
this Agreement or to carry on its obligations, and shall include the loss for
any reason to the Company of the services of Dr. Paul Averback.

     (g) "Principal Market" shall mean initially the Nasdaq SmallCap Market, and
shall include the Nasdaq National Market, the American Stock Exchange or the New
York Stock Exchange if the Company is listed and trades on such market or
exchange, but shall not include the Montreal Stock Exchange.


                                      E-1



<PAGE>   2

     (h) "Registration Statement" shall mean the registration statement under
the Securities Act of 1933, as amended, to be filed with the Securities and
Exchange Commission for the registration of the Shares pursuant to the
Registration Rights Agreement attached hereto as Exhibit A.

     (i) "Shares" shall mean, collectively, the shares of Common Stock of the
Company being subscribed for hereunder and those shares of Common Stock issuable
to the Purchaser upon exercise of the Warrants.

     (j) "Trading Day" shall mean any day on which the Principal Market is open
for business.

     (k) "VWAP" shall mean the daily volume weighted average price of the
Company on the Nasdaq SmallCap Market or on any Principal Market as reported by
Bloomberg Financial using the AQR function.

                                   ARTICLE II

                        PURCHASE AND SALE OF COMMON STOCK

     Section 2.1 Purchase and Sale of Stock.

Subject to the terms and conditions of this Agreement, the Company shall issue
and sell to the Purchaser and the Purchaser shall purchase from the Company up
to Twelve Million Dollars ($12,000,000) of the Company's Common Stock, no par
value per share (the "Common Stock"), based on up to twenty-four (24) Draw Downs
of up to Five Hundred Thousand Dollars ($500,000) per Draw Down, or, subject to
satisfaction of the conditions set forth in Section 6.1(d), up to Seven Hundred
Fifty Thousand Dollars ($750,000) per Draw Down.

     Section 2.2 The Shares.

The Company has authorized and has reserved and covenants to continue to
reserve, free of preemptive rights and other similar contractual rights of
stockholders, a sufficient number of its authorized but unissued shares of its
Common Stock to cover the Shares to be issued in connection with all Draw Downs
requested under this Agreement. At no time will the Company request a Draw Down
which would result in the issuance of a number of shares of Common Stock
pursuant to this Agreement and the Warrants referred to in Section 5.2(f) which
exceeds 19.9% of the number of shares of Common Stock issued and outstanding on
the Closing Date without obtaining stockholder approval of such excess issuance.

     Section 2.3 Purchase Price and Closing.

The Company agrees to issue and sell to the Purchaser and, in consideration of
and in express reliance upon the representation, warranties, covenants, terms
and conditions of this Agreement, the Purchaser agrees to purchase that number
of the Shares to be issued in connection with each Draw Down. The closing under
this Agreement shall take place at the offices of Epstein Becker & Green, P.C.,
250 Park Avenue, New York, New York 10177 (the "Closing") at 10:00 a.m. E.S.T.
on (i) November 5, 1999, or (ii) such other time and place or on such date as
the Purchaser and the Company may agree upon (the "Closing Date"). Each party
shall deliver all documents, instruments and writings required to be delivered
by such party pursuant to this Agreement at or prior to the Closing.


                                      E-2



<PAGE>   3

                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

     Section 3.1 Representation and Warranties of the Company.

The Company hereby makes the following representations and warranties to the
Purchaser:

     (a) Organization, Good Standing and Power.

The Company is a corporation duly incorporated, validly existing and in good
standing under the federal laws of Canada and has the requisite corporate power
to own, lease and operate its properties and assets and to conduct its business
as it is now being conducted. The Company does not have any subsidiaries except
as set forth in the Company's Form 20-F for the year ended December 31, 1998,
including the accompanying financial statements (together with the Company's
Form 6-K for the six month period ended June 30, 1999, the "Form 20-F"), or on
Schedule 3.1(a) hereto. The Company and each such subsidiary is duly qualified
as a foreign corporation to do business and is in good standing in every
jurisdiction in which the nature of the business conducted or property owned by
it makes such qualification necessary except for any jurisdiction in which the
failure to be so qualified will not have a Material Adverse Effect on the
Company's financial condition.

     (b) Authorization, Enforcement.

The Company has the requisite corporate power and authority to enter into and
perform this Agreement and to issue and sell the Shares in accordance with the
terms hereof. The execution, delivery and performance of this Agreement by the
Company and the consummation by it of the transactions contemplated hereby and
thereby have been duly and validly authorized by all necessary corporate action,
and no further consent or authorization of the Company or its Board of Directors
or stockholders is required. This Agreement has been duly executed and
delivered, and constitutes a valid and binding obligation of the Company
enforceable against the Company in accordance with its terms, except as such
enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium, liquidation, conservatorship, receivership or
similar laws relating to, or affecting generally the enforcement of, creditor's
rights and remedies or by other equitable principles of general application.

     (c) Capitalization.

The authorized capital stock of the company and the shares thereof currently
issued and outstanding are as set forth in the Form 20-F or on Schedule 3.1(c)
hereto. All of the outstanding shares of the Company's Common Stock have been
duly and validly authorized and are fully-paid and non-assessable. Except as set
forth in this Agreement and the Registration Rights Agreement and as set forth
in the Form 20-F, or on Schedule 3.1(c) hereto, no shares of Common Stock are
entitled to preemptive rights or registration rights and there are no
outstanding options, warrants, scrip, rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities or rights
convertible into, any shares of capital stock of the Company. Furthermore,
except as set forth in this Agreement and as set forth in the Form 20-F or on
Schedule 3.1(c), there are no contracts, commitments, understandings, or
arrangements by which the Company is or may become bound to issue additional
shares of the capital stock of the Company or options, securities or rights
convertible into shares of capital stock of the Company. The Company is not a
party to any agreement granting registration rights to any person with respect
to any of its equity or debt securities. The Company is not a party to, and it
has no knowledge of, any agreement restricting the voting or transfer of any
shares of the capital stock of the Company. Except as set forth in the Form 20-F
or on Schedule 3.1(c) hereto, the offer and sale of all capital stock,
convertible securities, rights, warrants, or options of the Company issued prior
to the Closing complied with all applicable Canadian, United States Federal and
state securities laws, and no stockholder has a right of rescission or damages
with respect thereto which would have a Material Adverse Effect on the Company's
financial condition or operating results. The Company has made available to the
Purchaser true and correct copies of the Company's Articles of Incorporation as
in effect on the date hereof (the "Articles"), and the Company's Bylaws as in
effect on the date hereof (the "Bylaws"). The Principal Market for the Common
Stock in the United States is the Nasdaq SmallCap Market, and the Company has
not received any notice from such market questioning or threatening the
continued inclusion of the Common Stock on such market.


                                      E-3



<PAGE>   4

     (d) Issuance of Shares.

The Shares to be issued under this Agreement have been duly authorized by all
necessary corporate action and, when paid for or issued in accordance with the
terms hereof, the Shares shall be validly issued and outstanding, fully paid and
non-assessable, and the Purchaser shall be entitled to all rights accorded to a
holder of Common Stock.

     (e) No Conflicts.

The execution, delivery and performance of this Agreement by the Company and the
consummation by the Company of the transactions contemplated herein do not and
will not (i) violate any provision of the Company's Articles or Bylaws, (ii)
conflict with, or constitute a default (or an event which with notice or lapse
of time or both would become a default) under, or give to others any rights of
termination, amendment, acceleration or cancellation of, any agreement,
mortgage, deed of trust, indenture, note, bond, license, lease agreement,
instrument or obligation to which the Company is a party, (iii) create or impose
a lien, charge or encumbrance on any property of the Company under any agreement
or any commitment to which the Company is a party or by which the Company is
bound or by which any of its respective properties or assets are bound, or (iv)
result in a violation of any Canadian, United States Federal, state, local or
other foreign statute, rule, regulation, order, judgment or decree (including
any Canadian, United States Federal and state or provincial securities laws and
regulations) applicable to the Company or any of its subsidiaries or by which
any property or asset of the Company or any of its subsidiaries are bound or
affected, except, in all cases, for such conflicts, defaults, termination,
amendments, accelerations, cancellations and violations as would not,
individually or in the aggregate, have a Material Adverse Effect. The business
of the Company and its subsidiaries is not being conducted in violation of any
laws, ordinances or regulations of any governmental entity, except for possible
violations which singularly or in the aggregate do not and will not have a
Material Adverse Effect. The Company is not required under any Canadian, United
States Federal, state or local or provincial law, rule or regulation to obtain
any consent, authorization or order of, or make any filing or registration with,
any court or governmental agency in order for it to execute, deliver or perform
any of its obligations under this Agreement, or issue and sell the Shares in
accordance with the terms hereof (other than any filings which may be required
to be made by the Company with the Securities and Exchange Commission (the
"Commission"), the Montreal Stock Exchange or state or provincial securities
administrators subsequent to the Closing and any registration statement which
may be filed pursuant hereto); provided that, for purpose of the representation
made in this sentence, the Company is assuming and relying upon the accuracy of
the relevant representations and agreements of the Purchaser herein.


                                      E-4



<PAGE>   5

     (f) Commission Documents, Financial Statements.

The Common Stock of the Company is registered pursuant to Section 12(g) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), and, except as
disclosed in the Form 20-F or on Schedule 3.1(f) hereto, the Company has timely
filed all reports, schedules, forms, statements and other documents required to
be filed by it with the Commission pursuant to the reporting requirements of the
Exchange Act, including material filed pursuant to Section 13(a) or 15(d) of the
Exchange Act (all of the foregoing including filings incorporated by reference
therein being referred to herein as the "Commission Documents"). The Company has
delivered or made available to the Purchaser true and complete copies of the
Commission Documents filed with the Commission since December 31, 1997. The
Company has not provided to the Purchaser any information which, according to
applicable law, rule or regulation, should have been disclosed publicly by the
Company but which has not been so disclosed, other than with respect to the
transactions contemplated by this Agreement. As of its date, the Form 20-F for
the year ended December 31, 1998 and the Form 6-K for the period ended June 30,
1999 complied in all material respects with the requirements of the Exchange Act
and the rules and regulations of the Commission promulgated thereunder
applicable to such documents, and, as of its date neither the Form 20-F nor the
Form 6-K contained any untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary in order to make the
statements therein, in light of the circumstances under which they were made,
not misleading. The financial statements of the Company included in the
Commission Documents comply as to form in all material respects with applicable
accounting requirements and the published rules and regulations of the
Commission or other applicable rules and regulations with respect thereto. Such
financial statements have been prepared in accordance with Canadian generally
accepted accounting principles ("GAAP") applied on a consistent basis during the
periods involved (except (i) as may be otherwise indicated in such financial
statements or the notes thereto or (ii) in the case of unaudited interim
statements, to the extent they may not include footnotes or may be condensed or
summary statements), and fairly present in all material respects the financial
position of the Company and its subsidiaries as of the dates thereof and the
results of operations and cash flows for the periods then ended (subject, in the
case of unaudited statements, to normal year-end audit adjustments).


                                      E-5



<PAGE>   6

     (g) Subsidiaries.

The Form 20-F or Schedule 3.1(g) hereto sets forth each subsidiary of the
Company, showing the jurisdiction of its incorporation or organization and
showing the percentage of each person's ownership of the outstanding stock or
other interests of such subsidiary. For the purposes of this Agreement,
"subsidiary" shall mean any corporation or other entity of which at least a
majority of the securities or other ownership interests having ordinary voting
power (absolutely or contingently) for the election of directors or other
persons performing similar functions are at the time owned directly or
indirectly by the Company and/or any of its other subsidiaries. All of the
outstanding shares of capital stock of each subsidiary have been duly authorized
and validly issued, and are fully paid and non-assessable. There are no
outstanding preemptive, conversion or other rights, options, warrants or
agreements granted or issued by or binding upon any subsidiary for the purchase
or acquisition of any shares of capital stock of any subsidiary or any other
securities convertible into, exchangeable for or evidencing the rights to
subscribe for any shares of such capital stock. Neither the Company nor any
subsidiary is subject to any obligation (contingent or otherwise) to repurchase
or otherwise acquire or retire any shares of the capital stock of any subsidiary
or any convertible securities, rights, warrants or options of the type described
in the preceding sentence. Neither the Company nor any subsidiary is a party to,
nor has any knowledge of, any agreement restricting the voting or transfer of
any shares of the capital stock of any subsidiary.

     (h) No Material Adverse Effect.

Since June 30, 1999, the date through which the most recent semiannual report of
the Company on Form 6-K has been prepared and filed with the Commission, the
Company has not experienced or suffered any Material Adverse Effect, except as
disclosed on Schedule 3.1(h) hereof.

     (i) No Undisclosed Liabilities.

Except as disclosed in the Form 20-F or on Schedule 3.1(i) hereto, neither the
Company nor any of its subsidiaries has any liabilities, obligations, claims or
losses (whether liquidated or unliquidated, secured or unsecured, absolute,
accrued, contingent or otherwise) that would be required to be disclosed on a
balance sheet of the Company or any subsidiary (including the notes thereto) in
conformity with GAAP which are not disclosed in the Commission Documents, other
than those incurred in the ordinary course of the Company's or its subsidiaries
respective businesses since such date and which, individually or in the
aggregate, do not or would not have a Material Adverse Effect on the Company or
its subsidiaries.

     (j) No Undisclosed Events or Circumstances.

No event or circumstance has occurred or exists with respect to the Company or
its subsidiaries or their respective businesses, properties, prospects,
operations or financial condition, which, under applicable law, rule or
regulation, requires public disclosure or announcement by the Company but which
has not been so publicly announced or disclosed.


                                      E-6



<PAGE>   7

     (k) Indebtedness.

The Form 20-F or Schedule 3.1(k) hereto sets forth as of the date hereof all
outstanding secured and unsecured Indebtedness of the Company or any subsidiary,
or for which the Company or any subsidiary has commitments. For the purposes of
this Agreement, "Indebtedness" shall mean (a) any liabilities for borrowed money
or amounts owed in excess of $250,000 (other than trade accounts payable
incurred in the ordinary course of business), (b) all guaranties, endorsements
and contingent obligations in respect of Indebtedness of others, whether or not
the same are or should be reflected in the Company's balance sheet (or the notes
thereto), except guaranties by endorsement of negotiable instruments for deposit
or collection or similar transactions in the ordinary course of business; and
(c) the present value of any lease payments in excess of $250,000 due under
leases required to be capitalized in accordance with GAAP. Neither the Company
nor any subsidiary is in default with respect to any Indebtedness.

     (l) Title to Assets.

Each of the Company and the subsidiaries has good and marketable title to all of
its real and personal property reflected in the Commission Documents, free of
any mortgages, pledges, charges, liens, security interests or other
encumbrances, except for those indicated in the Form 20-F or on Schedule 3.1(1)
hereto or such that do not cause a Material Adverse Effect on the Company's
financial condition or operating results. All said leases of the Company and
each of its subsidiaries are valid and subsisting and in full force and effect.

     (m) Actions Pending.

There is no action, suit, claim, investigation or proceeding pending or, to the
knowledge of the Company, threatened against the Company or any subsidiary which
questions the validity of this Agreement or the transactions contemplated hereby
or any action taken or to be taken pursuant hereto or thereto. Except as set
forth in the Form 20-F or on Schedule 3.1(m) hereto, there is no action, suit,
claim, investigation or proceeding pending or, to the knowledge of the Company,
threatened, against or involving the Company, any subsidiary or any of their
respective properties or assets. There are no outstanding orders, judgments,
injunctions, awards or decrees of any court, arbitrator or governmental or
regulatory body against the Company or any subsidiary.

     (n) Compliance with Law.

The business of the Company and the subsidiaries has been and is presently being
conducted in accordance with all applicable Canadian, United States Federal,
state and local governmental laws, rules, regulations and ordinances, except as
set forth in the Form 20-F or on Schedule 3.1(n) hereto or such that do not
cause a Material Adverse Effect. The Company and each of its subsidiaries have
all franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals necessary for the conduct of their respective
businesses as now being conducted by them unless the failure to possess such
franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals, individually or in the aggregate, could not
reasonably be expected to have a Material Adverse Effect.

     (o) Taxes.

Except as set forth in the Form 20-F or on Schedule 3.1(o) hereto, the Company
and each of the subsidiaries has accurately prepared and filed all Canadian,
United States Federal, state and other tax returns required by law to be filed
by it, has paid or made provisions for the payment of all taxes shown to be due
and all additional assessments, and adequate provision have been and are
reflected in the financial statements of the Company and the subsidiaries for
all current taxes and other charges to which the Company or any subsidiary is
subject and which are not currently due and payable. Except as disclosed on
Schedule 3.1(o) hereto, none of the Canadian or United States federal income tax
returns of the Company or any subsidiary for the years subsequent to December
31, 1994 have been audited by the Internal Revenue Service or Canadian fiscal
authorities. The Company has no knowledge of any additional assessments,
adjustments or contingent tax liability (whether federal or state) pending or
threatened against the Company or any subsidiary for any period, nor of any
basis for any such assessment, adjustment or contingency.


                                      E-7



<PAGE>   8

     (p) Certain Fees.

Except as set forth on Schedule 3.1(p) hereto, no brokers, finders or financial
advisory fees or commissions will be payable by the Company or any subsidiary
with respect to the transactions contemplated by this Agreement.

     (q) Disclosure.

To the best of the Company's knowledge, neither this Agreement or the Schedules
hereto nor any other documents, certificates or instruments furnished to the
Purchaser by or on behalf of the Company or any subsidiary in connection with
the transactions contemplated by this Agreement contain any untrue statement of
a material fact or omits to state a material fact necessary in order to make the
statements made herein or therein, in the light of the circumstances under which
they were made herein or therein, not misleading.

     (r) Operation of Business.

The Company and each of the subsidiaries owns or possesses all patents,
trademarks, service marks, trade names, copyrights, licenses and authorizations
as set forth in the Form 20-F and on Schedule 3.1(r) hereto, and all rights with
respect to the foregoing, which are necessary for the conduct of its business as
now conducted without any conflict with the rights of others.

     (s) Regulatory Compliance.

Except as disclosed in the Form 20-F or on Schedule 3.1(s) hereto, the Company
and each of its subsidiaries have obtained all material approvals,
authorization, certificates, consents, licenses, orders and permits or other
similar authorizations of all governmental authorities, or from any other
person, that are required under any Food and Drug or Environmental Laws. The
Form 20-F or Schedule 3.1(s) hereto sets forth all material permits, licenses
and other authorizations (including approved applications for clinical trials or
pre-market approvals) issued under any Food and Drug or Environmental Laws to
the Company or its subsidiaries. "Environmental Laws" shall mean all applicable
laws and regulations in the United States or Canada relating to the protection
of the environment including, without limitation, all requirements pertaining to
reporting, licensing, permitting, controlling, investigating or remediating
emissions, discharges, releases or threatened releases of hazardous substances,
chemical substances, pollutants, contaminants or toxic substances, materials or
wastes, whether solid, liquid or gaseous in nature, into the air, surface water,
groundwater or land, or relating to the manufacture, processing, distribution,
use, treatment, storage, disposal, transport or handling of hazardous
substances, chemical substances, pollutants, contaminants or toxic substances,
material or wastes, whether solid, liquid or gaseous in nature. "Food and Drug
Laws" shall mean all applicable laws and regulations in the United States and
Canada relating to the development, testing, manufacturing and distribution of
pharmaceutical products. Except as set forth in the Form 20-F or on Schedule
3.1(s) hereto, the Company has all necessary governmental approvals required
under all Food and Drug and Environmental Laws and used in its business or in
the business of any of its subsidiaries. The Company and each of its
subsidiaries are also in compliance with all other limitations, restrictions,
conditions, standards, requirements, schedules and timetables required or
imposed under all Food and Drug and Environmental Laws. Except for such
instances as would not individually or in the aggregate have a Material Adverse
Effect, there are no past or present events, conditions, circumstances,
incidents, actions or omissions relating to or in any way affecting the Company
or its subsidiaries that violate or would violate any Food and Drug or
Environmental Law after the Closing or that may give rise to any liability, or
otherwise form the basis of any claim, action, demand, suit, proceeding,
hearing, study or investigation under any Environmental Law or Food and Drug
Law.


                                      E-8



<PAGE>   9

     (t) Books and Records.

The records and documents of the Company and its subsidiaries accurately reflect
in all material respects the information relating to the business of the Company
and the subsidiaries, the location and collection of their assets, and the
nature of all transactions giving rise to the obligations or accounts receivable
of the Company or any subsidiary.

     (u) Material Agreements.

Except as set forth in the Form 20-F, or on Schedule 3.1(u) hereto, neither the
Company nor any subsidiary is a party to any written or oral contract,
instrument, agreement, commitment, obligation, plan or arrangement, a copy of
which would be required to be filed with the Commission as an exhibit to a
registration statement on Form F-1 or other applicable form (collectively,
"Material Agreements") if the Company or any subsidiary were registering
securities under the Securities Act of 1933, as amended (the "Securities Act").
The Company and each of its subsidiaries has in all material respects performed
all the obligations required to be performed by them to date under the foregoing
agreements, have received no notice of default and, to the best of the Company's
knowledge are not in default under any Material Agreement now in effect, the
result of which could cause a Material Adverse Effect. No written or oral
contract, instruments, agreement, commitment, obligation, plan or arrangement of
the Company or of any subsidiary limits or shall limit the payment of dividends
on the Company's Common Stock.

     (v) Transactions with Affiliates.

Except as set forth in the Form 20-F or on Schedule 3.1(v) hereto, there are no
loans, leases, agreements, contracts, royalty agreements, management contracts
or arrangements or other continuing transactions exceeding $100,000 between (a)
the Company, any subsidiary or any of their respective customers or suppliers on
the one hand, and (b) on the other hand, any officer, employee, consultant or
director of the Company, or any of its subsidiaries, or any person owning any
capital stock of the Company or any subsidiary or any member of the immediate
family of such officer, employee, consultant, director or stockholder or any
corporation or other entity controlled by such officer, employee, consultant,
director or stockholder, or a member of the immediate family of such officer,
employee, consultant, director or stockholder.


                                      E-9




<PAGE>   10

     (w) Securities Act of 1933.

The Company has complied and will comply with all applicable Canadian and United
States Federal and state securities laws in connection with the offer, issuance
and sale of the Shares hereunder. Neither the Company nor anyone acting on its
behalf, directly or indirectly, has or will sell, offer to sell or solicit
offers to buy the Shares or similar securities to, or solicit offers with
respect thereto from, or enter into any preliminary conversations or
negotiations relating thereto with, any person (other than the Purchaser), so as
to bring the issuance and sale of the Shares and/or the Warrants under the
registration provisions of the Securities Act and applicable state securities
laws. Neither the Company nor any of its affiliates, nor any person acting on
its or their behalf, has engaged in any form of general solicitation or general
advertising (within the meaning of Regulation D under the Securities Act) in
connection with the offer or sale of the Shares.

     (x) Governmental Approvals.

Except as set forth in the Form 20-F or on Schedule 3.1(x) hereto, and except
for the filing of any notice prior or subsequent to the Closing that may be
required under applicable Canadian, United States Federal of state securities
laws (which if required, shall be filed on a timely basis), including the filing
of a registration statement or statements pursuant to this Agreement, no
authorization, consent, approval, license, exemption of, filing or registration
with any court or governmental department, commission, board, bureau, agency or
instrumentality, domestic or foreign, is or will be necessary for, or in
connection with, the execution or delivery of the Shares, or for the performance
by the Company of its obligations under this Agreement.

     (y) Employees.

Neither the Company nor any subsidiary has any collective bargaining
arrangements or agreements covering any of its employees, except as set forth in
the Form 20-F or on Schedule 3(y) hereto. Except as set forth in the Form 20-F
or on Schedule 3(y) hereto, neither the Company nor any subsidiary is in breach
of any employment contract, agreement regarding proprietary information,
noncompetition agreement, nonsolicitation agreement, confidentiality agreement,
or any other similar contract or restrictive covenant, relating to the right of
any officer, employee or consultant to be employed or engaged by the Company or
such subsidiary. Since the date of the June 30, 1999 Form 6-K, no officer,
consultant or key employee of the Company or any subsidiary whose termination,
either individually or in the aggregate, could have a Material Adverse Effect,
has terminated or, to the knowledge of the Company, has any present intention of
terminating his or her employment or engagement with the Company or any
subsidiary.

     (z) Absence of Certain Developments.

Except as provided in Form 20-F or the June 30, 1999 Form 6-K, or in Schedule
3.1(z) hereto, since December 31, 1998 neither the Company nor any subsidiary
has:


                                      E-10



<PAGE>   11

          (i) issued any stock, bonds or other corporate securities or any
rights, options or warrants with respect thereto;

          (ii) borrowed any amount or incurred or become subject to any
liabilities (absolute or contingent) except current liabilities incurred in the
ordinary course of business which are comparable in nature and amount to the
current liabilities incurred in the ordinary course of business during the
comparable portion of its prior fiscal year, as adjusted to reflect the current
nature and volume of the Company's or such subsidiary's business;

          (iii) discharged or satisfied any lien or encumbrance or paid any
obligation or liability (absolute or contingent), other than current liabilities
paid in the ordinary course of business;

          (iv) declared or made any payment or distribution of cash or other
property to stockholders with respect to its stock, or purchased or redeemed, or
made any agreements so to purchase or redeem, any shares of its capital stock;

          (v) sold, assigned or transferred any other tangible assets, or
canceled any debts or claims, except in the ordinary course of business;

          (vi) sold, assigned or transferred any patent rights, trademarks,
trade names, copyrights, trade secrets or other intangible assets or
intellectual property rights, or disclosed any proprietary confidential
information to any person except to customers in the ordinary course of business
or to the Purchaser or its representatives;

          (vii) suffered any substantial losses or waived any rights of material
value, whether or not in the ordinary course of business, or suffered the loss
of any material amount of prospective business;

          (viii) made any changes in employee compensation except in the
ordinary course of business and consistent with past practices;

          (ix) made capital expenditures or commitments therefor that aggregate
in excess of $500,000;

          (x) entered into any other material transaction, whether or not in the
ordinary course of business;

          (xi) suffered any material damage, destruction or casualty loss,
whether or not covered by insurance;

          (xii) experienced any material problems with labor or management in
connection with the terms and conditions of their employment; or

          (xiii) effected any two or more events of the foregoing kind which in
the aggregate would be material to the Company or its subsidiaries.


                                      E-11



<PAGE>   12

          (aa) Use of Proceeds.

The proceeds from the sale of the Shares will be used by the Company and its
subsidiaries for general corporate purposes.

          (bb) Acknowledgment Regarding Purchaser's Purchase of Shares.

Company acknowledges and agrees that Purchaser is acting solely in the capacity
of arm's length purchaser with respect to this Agreement and the transactions
contemplated hereunder. The Company further acknowledges that the Purchaser is
not acting as a financial advisor or fiduciary of the Company (or in any similar
capacity) with respect to this Agreement and the transactions contemplated
hereunder and any advice given by the Purchaser or any of its representatives or
agents in connection with this Agreement and the transactions contemplated
hereunder is merely incidental to the Purchaser's purchase of the Shares. The
Company further represents to the Purchaser that the Company's decision to enter
into this Agreement has been based solely on the independent evaluation by the
Company and its own representatives and counsel.

     Section 3.2 Representations and Warranties of the Purchaser.

The Purchaser hereby makes the following representations and warranties to the
Company:

          (a) Organization and Standing of the Purchaser.

The Purchaser is a corporation duly incorporated, validly existing and in good
standing under the laws of the British Virgin Islands.

          (b) Authorization and Power.

The Purchaser has the requisite power and authority to enter into and perform
this Agreement and to purchase the Shares being sold to it hereunder. The
execution, delivery and performance of this Agreement by Purchaser and the
consummation by it of the transactions contemplated hereby have been duly
authorized by all necessary corporate action.

          (c) No Conflicts.

The execution, delivery and performance of this Agreement and the consummation
by the Purchaser of the transactions contemplated hereby or relating hereto do
not and will not (i) result in a violation of such Purchaser's charter documents
or bylaws or (ii) conflict with, or constitute a default (or an event which with
notice or lapse of time or both would become a default) under, or give to others
any rights of termination, amendment, acceleration or cancellation of any
agreement, indenture or instrument to which the Purchaser is a party, or result
in a violation of any law, rule, or regulation, or any order, judgment or decree
of any court or governmental agency applicable to the Purchaser or its
properties (except for such conflicts, defaults and violations as would not,
individually or in the aggregate, have a Material Adverse Effect on Purchaser).
The Purchaser is not required to obtain any consent, authorization or order of,
or make any filing or registration with, any court or governmental agency in
order for it to execute, deliver or perform any of its obligations under this
Agreement or to purchase the Shares in accordance with the terms hereof,
provided that for purposes of the representation made in this sentence, the
Purchaser is assuming and relying upon the accuracy of the relevant
representations and agreements of the Company herein.


                                      E-12



<PAGE>   13

          (d) Financial Risks.

The Purchaser acknowledges that it is able to bear the financial risks
associated with an investment in the Shares and that it has been given full
access to such records of the Company and the subsidiaries and to the officers
of the Company and the subsidiaries as it has deemed necessary or appropriate to
conduct its due diligence investigation. The Purchaser is capable of evaluating
the risks and merits of an investment in the Shares by virtue of its experience
as an investor and its knowledge, experience, and sophistication in financial
and business matters and the Purchaser is capable of bearing the entire loss of
its investment in the Shares.

          (e) Accredited Investor.

The Purchaser is an "accredited investor" as defined in Regulation D promulgated
under the Securities Act.

          (f) Compliance With Law.

The Purchaser's trading and distribution activities with respect to the Shares
will be in compliance with all applicable state and Federal securities laws,
rules and regulations and the rules and regulations of the Principal Market. The
Purchaser understands that the Shares will not be saleable by it on the Montreal
Stock Exchange without the express prior approval of that stock exchange, which
neither the Company nor the Purchaser is under any obligation to obtain.

          (g) General.

The Purchaser understands that the Company is relying upon the truth and
accuracy of the representations, warranties, agreements, acknowledgments and
understandings of the Purchaser set forth herein in order to determine the
suitability of the Purchaser to acquire the Shares.

                                   ARTICLE IV

                                   COVENANTS

     The Company covenants with the Purchaser as follows:

     Section 4.1 Securities Compliance.

     The Company shall notify The Nasdaq Stock Market, Inc., in accordance with
their rules and regulations, of the transactions contemplated by this Agreement,
and shall take all other necessary action and proceedings as may be required and
permitted by applicable law, rule and regulation, for the legal and valid
issuance of the Shares and the Warrants to the Purchaser or subsequent holders.

     Section 4.2 Registration and Listing.

The Company will cause its Common Stock to continue to be registered under
Sections 12(b) or 12(g) of the Exchange Act, will comply in all respects with
its reporting and filing obligations under the Exchange Act, will comply with
all requirements related to any registration statement filed pursuant to this
Agreement, and will not take any action or file any document (whether or not
permitted by the Securities Act or the rules promulgated thereunder) to
terminate or suspend such registration or to terminate or suspend its reporting
and filing obligations under the Exchange Act or Securities Act, except as
permitted herein. The Company will take all action necessary to continue the
listing or trading of its Common Stock on the Nasdaq SmallCap Market or another
Principal Market and will comply in all respects with the Company's reporting,
filing and other obligations under the bylaws or rules of the NASD and The
Nasdaq Stock Market.


                                      E-13



<PAGE>   14

     Section 4.3 Registration Statement.

The Company shall cause to be filed the Registration Statement, which
Registration Statement shall provide for the sale of the Shares to the Purchaser
and resale by the Purchaser to the public in accordance with this Agreement. The
Company shall cause such Registration Statement to be declared effective by the
Commission as expeditiously as practicable. Before the Purchaser shall be
obligated to accept a Draw Down request from the Company, the Company shall have
caused a sufficient number of shares of Common Stock to be registered to cover
the Shares to be issued in connection with such Draw Down.

     Section 4.4 Escrow Arrangement.

The Company and the Purchaser shall enter into an escrow arrangement with
Epstein Becker & Green, P.C. (the "Escrow Agent") in the Form of Exhibit B
hereto respecting payment against delivery of the Shares.

     Section 4.5 Compliance with Laws.

The Company shall comply, and cause each subsidiary to comply, with all
applicable laws, rules, regulations and orders, noncompliance with which could
have a Material Adverse Effect.

     Section 4.6 Keeping of Records and Books of Account.

The Company shall keep and cause each subsidiary to keep adequate records and
books of account, in which complete entries will be made in accordance with
Canadian GAAP consistently applied, reflecting all financial transactions of the
Company and its subsidiaries, and in which, for each fiscal year, all proper
reserves for depreciation, depletion, obsolescence, amortization, taxes, bad
debts and other purposes in connection with its business shall be made.

     Section 4.7 Amendments.

The Company shall not amend or waive any provision the Articles of
Incorporation, Bylaws of the Company in any way that would adversely affect the
dividend rights or voting rights of the holders of the Shares.

     Section 4.8 Other Agreements.

The Company shall not enter into any agreement the terms of which such agreement
would restrict or impair the right to perform of the Company or any subsidiary
under this Agreement or the Articles of Incorporation of the Company.


                                      E-14



<PAGE>   15
     Section 4.9 Notice of Certain Events Affecting Registration; Suspension of
     Right to Request a Draw Down.

The Company will immediately notify the Purchaser upon the occurrence of any of
the following events in respect of the Registration Statement or related
prospectus in respect of the Shares: (i) receipt of any request for additional
information from the Commission or any other Federal or state governmental
authority during the period of effectiveness of the Registration Statement the
response to which would require any amendments or supplements to the
Registration Statement or related prospectus; (ii) the issuance by the
Commission or any other Federal or state governmental authority of any stop
order suspending the effectiveness of the Registration Statement or the
initiation of any proceedings for that purpose; (iii) receipt of any
notification with respect to the suspension of the qualification or exemption
from qualification of any of the Shares for sale in any jurisdiction or the
initiation or threatening of any proceeding for such purpose; (iv) the happening
of any event that makes any statement made in the Registration Statement or
related prospectus or any document incorporated or deemed to be incorporated
therein by reference untrue in any material respect or that requires the making
of any changes in the Registration Statement, related prospectus or documents so
that, in the case of the Registration Statement, it will not contain any untrue
statement of a material fact or omit to state any material fact required to be
stated therein or necessary to make the statements therein not misleading, and
that in the case of the related prospectus, it will not contain any untrue
statement of a material fact or omit to state any material fact required to be
stated therein or necessary to make the statements therein, in the light of the
circumstances under which they were made, not misleading; and (v) the Company's
reasonable determination that a post-effective amendment to the Registration
Statement would be appropriate; and the Company will promptly make available to
the Purchaser any such supplement or amendment to the related prospectus. The
Company shall not deliver to the Purchaser any Draw Down Notice during the
continuation of any of the foregoing events.

     Section 4.10 Consolidation; Merger.

The Company shall not, at any time after the date hereof, effect any merger or
consolidation of the Company with or into, or a transfer of all or substantially
all of the assets of the Company to, another entity (a "Consolidation Event")
unless the resulting successor or acquiring entity (if not the Company) assumes
by written instrument or by operation of law the obligation to deliver to the
Purchaser such shares of stock and/or securities as the Purchaser is entitled to
receive pursuant to this Agreement.

     Section 4.11 Limitation on Future Financing.

The Company agrees that, except as set forth below, it will not enter into any
sale of its securities for cash at a discount to the current market price until
the earlier of (i) eighteen (18) months from the effective date of the
Registration Statement or, if later, the date the Company has drawn down at
least $8,000,000 or (ii) sixty (60) days after the entire $12,000,000 of Shares
has been purchased by Purchaser. The foregoing shall not prevent or limit the
Company from engaging in any sale of securities (i) in a registered public
offering by the Company which is underwritten by one or more established
investment banks, (ii) in one or more private placements where the purchasers do
not have registration rights, (iii) pursuant to any presently existing or future
employee benefit plan which plan has been or is approved by the Company's
stockholders, (iv) pursuant to any compensatory plan for a full-time employee or
key consultant, (v) in connection with a strategic partnership or other business
transaction, the principal purpose of which is not simply to raise money, or
(vi) to which Purchaser gives its written approval.


                                      E-15



<PAGE>   16

                                    ARTICLE V

                      CONDITIONS TO CLOSING AND DRAW DOWNS

     Section 5.1 Conditions Precedent to the Obligation of the Company to Sell
     the Shares.

The obligation hereunder of the Company to issue and sell the Shares to the
Purchaser is subject to the satisfaction or waiver, at or before the Closing, of
each of the conditions set forth below. These conditions are for the Company's
sole benefit and may be waived by the Company at any time in its sole
discretion.

          (a) Accuracy of the Purchaser's Representations and Warranties.

The representations and warranties of the Purchaser shall be true and correct in
all material respects as of the date when made and as of the Closing and as of
each Draw Down Exercise Date as though made at that time, except for
representations and warranties that speak as of a particular date.

          (b) Performance by the Purchaser.

The Purchaser shall have performed, satisfied and complied in all material
respects with all material covenants, agreements and conditions required by this
Agreement to be performed, satisfied or complied with by the Purchaser at or
prior to the Closing and as of each Draw Down Exercise Date.

          (c) No Injunction.

No statute, rule, regulation, executive order, decree, ruling or injunction
shall have been enacted, entered, promulgated or endorsed by any court or
governmental authority of competent jurisdiction which prohibits the
consummation of any of the transactions contemplated by this Agreement.

     Section 5.2 Conditions Precedent to the Obligation of the Purchaser to
     Close.

The obligation hereunder of the Purchaser to enter this Agreement is subject to
the satisfaction or waiver, at or before the Closing, of each of the conditions
set forth below. These conditions are for the Purchaser's sole benefit and may
be waived by the Purchaser at any time in its sole discretion.

          (a) Accuracy of the Company's Representations and Warranties.

Each of the representations and warranties of the Company shall be true and
correct in all material respects as of the date when made and as of the Closing
as though made at that time (except for representations and warranties that
speak as of a particular date).


                                      E-16



<PAGE>   17

          (b) Performance by the Company.

The Company shall have performed, satisfied and complied in all respects with
all covenants, agreements and conditions required by this Agreement to be
performed, satisfied or complied with by the Company at or prior to the Closing.

          (c) No Injunction.

No statute, rule, regulation, executive order, decree, ruling or injunction
shall have been enacted, entered, promulgated or endorsed by any court or
governmental authority of competent jurisdiction which prohibits the
consummation of any of the transactions contemplated by this Agreement.

          (d) No Proceedings or Litigation.

No action, suit or proceeding before any arbitrator or any governmental
authority shall have been commenced, and no investigation by any governmental
authority shall have been threatened, against the Purchaser or the Company or
any subsidiary, or any of the officers, directors or affiliates of the Company
or any subsidiary seeking to restrain, prevent or change the transactions
contemplated by this Agreement, or seeking damages in connection with such
transactions.

          (e) Opinion of Counsel, Etc.

At the Closing, the Purchaser shall have received an opinion of counsel to the
Company, dated the date of Closing, in the form of Exhibit C hereto, and such
other certificates and documents as the Purchaser or its counsel shall
reasonably require incident to the Closing.

          (f) Warrants.

In lieu of a minimum Draw Down commitment by the Company, the Purchaser shall
receive warrants to purchase up to Two Hundred Thousand (200,000) shares of
Common Stock (the "Warrants") at the Closing. The Warrants will vest as set
forth therein and have a five (5) year term from their date of issuance. The
Warrant strike price shall be 110% of the VWAP of the Common Stock on the
Closing Date. The Common Stock underlying the Warrants will be registered in the
Registration Statement referred to in Section 4.3 hereof. The Warrants shall be
in the form of Exhibit D hereto.

     Section 5.3 Conditions Precedent to the Obligation of the Purchaser to
Accept a Draw Down and Purchase the Shares.

The obligation hereunder of the Purchaser to accept a Draw Down request and to
acquire and pay for the Shares is subject to the satisfaction or waiver, at or
before each Draw Down Exercise Date, of each of the conditions set forth below.
The conditions are for the Purchaser's sole benefit and may be waived by the
Purchaser at any time in its sole discretion.

          (a) Satisfaction of Conditions to Closing.

The Company shall have satisfied, or the Purchaser shall have waived, the
conditions set forth in Section 5.2 hereof


                                      E-17



<PAGE>   18
          (b) Effective Registration Statement.

The Registration Statement registering the Shares shall have been declared
effective by the Commission and shall remain effective on each Draw Down
Exercise Date.

          (c) No Suspension.

Trading in the Company's Common Stock shall not have been suspended by the
Commission or The Nasdaq Stock Market, Inc. (except for any suspension of
trading of limited duration agreed to by the Company, which suspension shall be
terminated prior to each Draw Down request), and, at any time prior to such
request, trading in securities generally as reported by Nasdaq shall not have
been suspended or limited, or minimum prices shall not have been established on
securities whose trades are reported by Nasdaq.

          (d) Material Adverse Effect.

No Material Adverse Effect and no Consolidation Event shall have occurred.

          (e) Opinion of Counsel.

The Purchaser shall have received a "down-to-date" letter from the Company's
counsel, confirming that there is no change from the counsel's previously
delivered opinion, or else specifying with particularity the reason for any
change.

                                   ARTICLE VI

                                 DRAW DOWN TERMS

     Section 6.1 Draw Down Terms.

Subject to the satisfaction of the conditions set forth in this Agreement, the
parties agree as follows:

          (a) The Company, may, in its sole discretion, issue and exercise a
draw down (a "Draw Down") during each Draw Down Pricing Period, which Draw Down
the Purchaser will be obligated to accept.

          (b) Only one Draw Down shall be allowed in each Draw Down Pricing
Period. The price per share paid by the Purchaser shall be based on the Average
Daily Price on each separate Trading Day during the Draw Down Pricing Period.
The number of shares of Common Stock purchased by the Purchaser with respect to
each Draw Down shall be determined on a daily basis during each Draw Down
Pricing Period and settled on the Draw Down Exercise Date, which shall be the
first Trading Day following the end of the Draw Down Pricing Period. In
connection with each Draw Down Pricing Period, the Company may set an Average
Daily Price below which the Company will not sell any Shares (the "Threshold
Price"). If the Average Daily Price on any day within the Draw Down Pricing
Period is less than the Threshold Price, the Company shall not sell and the
Purchaser shall not be obligated to purchase the Shares otherwise to be
purchased for such day.

          (c) There shall be a minimum of five (5) Trading Days between the end
of a Draw Down Pricing Period and the next Draw Down Notice. There shall be a
maximum of twenty four (24) Draw Downs during the terms of this Agreement.


                                      E-18



<PAGE>   19

          (d) The Company shall have the right to issue and exercise a Draw Down
of up to $500,000 of the Company's Common Stock per Draw Down, subject to the
limitations set forth immediately below. The minimum Draw Down shall be $150,000
unless otherwise agreed by Purchaser. The maximum dollar amount of each Draw
Down during any Draw Down Pricing Period shall be limited pursuant to the
following formula:

<TABLE>
<S>                          <C>
Average Stock Price:         Average of the Average Daily Prices for the 22
                             Trading Days prior to the Draw Down Notice date.

Average Trading Volume:      Average daily trading volume for the 45 Trading
                             Days prior to the Draw Down Notice date.
Maximum dollar amount of
each Draw Down:              20% of (Average Stock Price*(Average Trading
                             Volume*22))
</TABLE>

Notwithstanding the foregoing, the Company shall be permitted to issue a Draw
Down Notice for up to Seven Hundred Fifty Thousand ($750,000) if during the
thirty Trading Days ending on the Trading Day immediately prior to the date of
such Draw Down Notice the average daily trading volume on the Principal Market
has been at least 60,000 shares and the average of the Average Daily Prices is
at least $4.50 per share.

          (e) The number of Shares of Common Stock to be issued in connection
with each Draw Down shall be equal to the sum of the quotients (for each trading
day within the Draw Down Pricing Period) of (x) 1/22nd of the Draw Down amount
and (y) 94% of the Average Daily Price of the Common Stock on each Trading Day
within the Draw Down Pricing Period.

          (f) The Company must inform the Purchaser via facsimile transmission
as to the amount of the Draw Down the Company wishes to exercise before the
first day of the Draw Down Pricing Period (the "Draw Down Notice"). The Company
may set the Threshold Price, if any, prior to each Draw Down request. At no time
shall the Purchaser be required to purchase more than the scheduled Draw Down
amount for a given Draw Down Pricing Period so that if the Company chooses not
to exercise the maximum permitted Draw Down in a given Draw Down Pricing Period
the Purchaser is not obligated to purchase more than the scheduled maximum
amount in a subsequent Draw Down Pricing Period.

          (g) On or before three Trading Days after each Draw Down Exercise
Date, the Shares purchased by the Purchaser shall be delivered to The Depository
Trust Company ("DTC") on the Purchaser's behalf. The Shares shall be credited by
the Company to the DTC account designated by the Purchaser upon receipt by the
Escrow Agent of payment for the Draw Down into the Escrow Agent's trust account
as provided in the Escrow Agreement. The Escrow Agent shall be directed to pay
97% of the purchase price to the Company and 3% to the placement agent. The
delivery of the Shares into the Purchaser's DTC account in exchange for payment
therefor shall be referred to herein as "Settlement".


                                      E-19



<PAGE>   20

                                   ARTICLE VII

                                   TERMINATION

     Section 7.1 Termination by Mutual Consent.

The term of this Agreement shall be thirty (30) months from the initial Draw
Down. This Agreement may be terminated at any time by mutual consent of the
parties.

     Section 7.2 Other Termination.

The Purchaser may terminate this Agreement upon one (1) Trading Day's notice if
(i) an event resulting in a Material Adverse Effect has occurred, (ii) the
Common Stock is de-listed from the Nasdaq SmallCap Market unless such de-listing
is in connection with the listing of the Common Stock on the Nasdaq National
Market, the New York or American Stock Exchanges, (iii) the Company files for
protection from creditors under any applicable law, (iv) the Company completes
any financing prohibited by Section 4.11 or (v) the Registration Statement is
not effective by April 15, 2000.

     The Company may terminate this Agreement upon one (1) Trading Day's notice
if (i) the Company has completed Draw Downs of at least Eight Million Dollars
($8,000,000) or (ii) the Purchaser shall fail to fund more than one properly
noticed Draw Down within three (3) Trading Days of the date payment for such
Draw Down is due.

     Section 7.3 Effect of Termination.

In the event of termination by the company or the Purchaser, written notice
thereof shall forthwith be given to the other party and the transactions
contemplated by this Agreement shall be terminated without further action by
either party. If this Agreement is terminated as provided in Section 7.1 or 7.2
herein, this Agreement shall become void and of no further force and effect,
except for Sections 9.1 and 9.2, and Article VIII herein. Nothing in this
Section 7.3 shall be deemed to release the Company or the Purchaser from any
liability for any breach under this Agreement, or to impair the rights to the
Company and the Purchaser to compel specific performance by the other party of
its obligations under this Agreement.

                                  ARTICLE VIII

                                 INDEMNIFICATION

     Section 8.1 General Indemnity.

The Company agrees to indemnify and hold harmless the Purchaser (and its
directors, officers, affiliates, agents, successors and assigns) from and
against any and all losses, liabilities, deficiencies, costs, damages and
expenses (including, without limitation, reasonable attorney's fees, charges and
disbursements) incurred by the Purchaser as a result of any inaccuracy in or
breach of the representations, warranties or covenants made by the Company
herein. The Purchaser agrees to indemnify and hold harmless the Company and its
directors, officers, affiliates, agents, successors and assigns from and against
any and all losses, liabilities, deficiencies, costs, damages and expenses
(including, without limitation, reasonable attorneys fees, charges and
disbursements) incurred by the Company as result of any inaccuracy in or breach
of the representations, warranties or covenants made by the Purchaser herein.


                                      E-20



<PAGE>   21

     Section 8.2 Indemnification Procedure.

Any party entitled to indemnification under this Article VIII (an "indemnified
party") will give written notice to the indemnifying party of any matters giving
rise to a claim for indemnification; provided, that the failure of any party
entitled to indemnification hereunder to give notice as provided herein shall
not relieve the indemnifying party of its obligations under this Article VIII
except to the extent that the indemnifying party is actually prejudiced by such
failure to give notice. In case any action, proceeding or claim is brought
against an indemnified party in respect of which indemnification is sought
hereunder, the indemnifying party shall be entitled to participate in and,
unless in the reasonable judgment of counsel to the indemnified party a conflict
of interest between it and the indemnifying party may exist with respect of such
action, proceeding or claim, to assume the defense thereof with counsel
reasonably satisfactory to the indemnified party. In the event that the
indemnifying party advises an indemnified party that it will contest such a
claim for indemnification hereunder, or fails, within thirty (30) days of
receipt of any indemnification notice to notify, in writing, such person of its
election to defend, settle or compromise, at its sole cost and expense, any
action, proceeding or claim (or discontinues its defense at any time after it
commences such defense), then the indemnified party may, at its option, defend,
settle or otherwise compromise or pay such action or claim. In any event, unless
and until the indemnifying party elects in writing to assume and does so assume
the defense of any such claim, proceeding or action, the indemnified party's
costs and expenses arising out of the defense, settlement or compromise of any
such action, claim or proceeding shall be losses subject to indemnification
hereunder. The indemnified party shall cooperate fully with the indemnifying
party in connection with any settlement negotiations or defense of any such
action or claim by the indemnifying party and shall furnish to the indemnifying
party all information reasonably available to the indemnified party which
relates to such action or claim. The indemnifying party shall keep the
indemnified party fully apprised at all times as to the status of the defense or
any settlement negotiations with respect thereto. If the indemnifying party
elects to defend any such action or claim, then the indemnified party shall be
entitled to participate in such defense with counsel of its choice at its sole
cost and expense. The indemnifying party shall not be liable for any settlement
of any action, claim or proceeding effected without its prior written consent.
Notwithstanding anything in this Article VIII to the contrary, the indemnifying
party shall not, without the indemnified party's prior written consent, settle
or compromise any claim or consent to entry of any judgment in respect thereof
which imposes any future obligation on the indemnified party or which does not
include, as an unconditional term thereof, the giving by the claimant or the
plaintiff to the indemnified party of a release from all liability in respect of
such claim. The indemnification required by this Article VIII shall be made by
periodic payments of the amount thereof during the course of investigation or
defense, as and when bills are received or expense, loss, damage or liability is
incurred, so long as the indemnified party irrevocably agrees to refund such
moneys if it is ultimately determined by a court of competent jurisdiction that
such party was not entitled to indemnification. The indemnity agreements
contained herein shall be in addition to (a) any cause of action or similar
rights of the indemnified party against the indemnifying party or others, and
(b) any liabilities the indemnifying party may be subject to.


                                      E-21



<PAGE>   22

                                   ARTICLE IX

                                  MISCELLANEOUS

     Section 9.1 Fees and Expenses.

The Company shall pay all fees and expenses related to the transactions
contemplated by this Agreement; provided, that the Company shall pay, at the
Closing, all attorneys and escrow fees and expenses (exclusive of disbursements
and out-of-pocket expenses) incurred by the Purchaser of $35,000 in connection
with the preparation, negotiation, execution and delivery of this Agreement and
the transactions contemplated hereunder and which will include all ordinary
services of the Escrow Agent in connection with each Draw Down. In addition, the
Company shall pay all reasonable fees and expenses incurred by the Purchaser in
connection with any amendments, modifications or waivers of this Agreement or
the Registration Rights Agreement or incurred in connection with the enforcement
of this Agreement and the Registration Rights Agreement, including, without
limitation, all reasonable attorneys fees and expenses. The Company shall pay
all stamp or other similar taxes and duties levied in connection with issuance
of the Shares pursuant hereto.

     Section 9.2 Specific Enforcement, Consent to Jurisdiction.

          (a) The Company and the Purchaser acknowledge and agree that
irreparable damage would occur in the event that any of the provisions of this
Agreement were not performed in accordance with their specific terms or were
otherwise breached. It is accordingly agreed that the parties shall be entitled
to an injunction or injunctions to prevent or cure breaches of the provisions of
this Agreement and to enforce specifically the terms and provisions hereof or
thereof, this being in addition to any other remedy to which any of them may be
entitled by law or equity.

          (b) Each of the Company and the Purchaser (i) hereby irrevocably
submits to the jurisdiction of the United States District Court and other courts
of the United States sitting in the Southern District of New York for the
purposes of any suit, action or proceeding arising out of or relating to this
Agreement and (ii) hereby waives, and agrees not to assert in any such suit,
action or proceeding, any claim that it is not personally subject to the
jurisdiction of such court, that the suit, action or proceeding is brought in an
inconvenient forum or that the venue of the suit, action or proceeding is
improper. Each of the Company and the Purchaser consents to process being served
in any such suit, action or proceeding by mailing a copy thereof by certified
mail, return receipt requested, to such party at the address in effect for
notices to it under this Agreement and agrees that such service shall constitute
good and sufficient service of process and notice thereof. Nothing in this
Section shall affect or limit any right to serve process in any other manner
permitted by law.


                                      E-22



<PAGE>   23

     Section 9.3 Entire Agreement; Amendment.

This Agreement, together with the Registration Rights Agreement and the Escrow
Agreement contains the entire understanding of the parties with respect to the
matters covered hereby and, except as specifically set forth herein, neither the
Company nor the Purchaser makes any representations, warranty, covenant or
undertaking with respect to such matters. No provision of this Agreement may be
waived or amended other than by a written instrument signed by the party against
whom enforcement of any such amendment or waiver is sought.

     Section 9.4 Notices.

Any notice, demand, request, waiver or other communication required or permitted
to be given hereunder shall be in writing and shall be effective (a) upon hand
delivery or facsimile at the address or number designated below (if delivered on
a business day during normal business hours where such notice is to be
received), or the first business day following such delivery (if delivered other
than on a business day during normal business hours where such notice is to be
received) or (b) on the second business day following the date of mailing by
express courier service, fully prepaid, addressed to such address, or upon
actual receipt of such mailing, whichever shall first occur. The addresses for
such communications shall be:

         If to the Company: Nymox Pharmaceutical Corporation
                  9900 Cavendish Blvd.
                  St. Laurent, Quebec, Canada H4M 2V2
                  Telephone Number:  (800) 936-9669
                  Fax:  (514) 332-9167
                  Attention: Dr. Paul Averback, President

         If to Purchaser: Jaspas Investments Limited
                  c/o Dr. Batliner & Partners
                  Aeulestrasse 74
                  FI-9490 Vaduz, Liechtenstein
                  Telephone Number: 011-41-75-2360
                  Fax: 011-41-75-2360-405
                  Attention: Hans Gassner

         with copies to: Epstein Becker & Green, P.C.
                  250 Park Avenue
                  New York, New York 10177
                  Telephone Number:  (212) 351-4924
                  Fax:  (212) 661-0989
                  Attention: Joseph A. Smith

     Any party hereto may from time to time change its address for notices by
giving written notice of such changed address to the other party hereto in
accordance herewith.

     Section 9.5 Waivers.

No waiver by either party of any default with respect to any provision,
condition or requirement of this Agreement shall be deemed to be a continuing
waiver in the future or a waiver of any other provisions, condition or
requirement hereof, nor shall any delay or omission of any party to exercise any
right hereunder in any manner impair the exercise of any such right accruing to
it thereafter.


                                      E-23



<PAGE>   24

     Section 9.6 Headings.

The article, section and subsection headings in this Agreement are for
convenience only and shall not constitute a part of this Agreement for any other
purpose and shall not be deemed to limit or affect any of the provisions hereof.

     Section 9.7 Successors and Assigns.

This Agreement shall be binding upon and inure to the benefit of the parties and
their successors and assigns. The parties hereto may not amend this Agreement or
any rights or obligations hereunder without the prior written consent of the
Company and each Purchaser to be affected by the amendment. After Closing, the
assignment by a party to this Agreement of any rights hereunder shall not affect
the obligations of such party under this Agreement.

     Section 9.8 No Third Party Beneficiaries.

This Agreement is intended for the benefit of the parties hereto and their
respective permitted successors and assigns and is not for the benefit of, nor
may any provision hereof be enforced by, any other person.

     Section 9.9 Governing Law.

This Agreement shall be governed by and construed in accordance with the
internal laws of the State of New York, without giving effect to the choice of
law provisions.

     Section 9.10 Counterparts.

This Agreement may be executed in any number of counterparts, all of which taken
together shall constitute one and the same instrument and shall become effective
when counterparts have been signed by each party and delivered to the other
parties hereto, it being understood that all parties need not sign the same
counterpart. Execution may be made by delivery by facsimile.

     Section 9.11 Publicity.

Prior to the Closing, neither the Company nor the Purchaser shall issue any
press release or otherwise make any public statement or announcement with
respect to this Agreement or the transactions contemplated hereby or the
existence of this Agreement. After the Closing, the Company may issue a press
release or otherwise make a public statement or announcement with respect to
this Agreement or the transactions contemplated hereby or the existence of this
Agreement; provided, that prior to issuing any such press release, making any
such public statement or announcement, the Company obtains the prior consent of
the Purchaser, which consent shall not be unreasonably withheld or delayed.

     Section 9.12 Severability.

The provisions of this Agreement are severable and, in the event that any court
of competent jurisdiction shall determine that any one or more of the provisions
or part of the provisions contained in this Agreement shall, for any reason, be
held to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other provision or part of a
provision of this Agreement and this Agreement shall be reformed and construed
as if such invalid or illegal or unenforceable provision, or part of such
provision, had never been contained herein, so that such provisions would be
valid, legal and enforceable to the maximum extent possible.


                                      E-24



<PAGE>   25
     Section 9.13 Further Assurances.

From and after the date of this Agreement, upon the request of the Purchaser or
the Company, each of the Company and the Purchaser shall execute and deliver
such instruments, documents and other writings as may be reasonably necessary or
desirable to confirm and carry out and to effectuate fully the intent and
purposes of this Agreement.

     Section 9.14 Currencies.

Unless otherwise specified, all references herein to dollars means United States
dollars.

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed by their respective authorize officer as of the date first above
written.

                        NYMOX PHARMACEUTICAL CORPORATION

                        By: /s/ Paul Averback
                            ------------------------------
                        Name:   Dr. Paul Averback
                        Title:  President

                        JASPAS INVESTMENTS LIMITED

                        By: /s/ Hans Gassner
                            ------------------------------
                        Name:   Hans Gassner
                        Title:  Authorized Signatory


                                      E-25

<PAGE>   1


EXHIBIT 2.1

                         REGISTRATION RIGHTS AGREEMENT

     THIS REGISTRATION RIGHTS AGREEMENT, dated as of November 1, 1999, between
Jaspas Investments Limited ("Purchaser"), and Nymox Pharmaceutical Corporation
(the "Company").

     WHEREAS, simultaneously with the execution and delivery of this Agreement,
pursuant to a Common Stock Purchase Agreement dated the date hereof (the
"Purchase Agreement") the Purchaser has committed to purchase up to $12,000,000
worth of the Company's Common Stock (terms not defined herein shall have the
meanings ascribed to them in the Purchase Agreement); and

     WHEREAS, the Company desires to grant to the Purchaser the registration
rights set forth herein with respect to the Shares and the Shares issuable upon
exercise of the Warrants from time to time (the "Warrant Shares") (hereinafter
referred to collectively as the "Stock" or "Securities" of the Company).

     NOW, THEREFORE, the parties hereto mutually agree as follows:

     Section 1. Registrable Securities. As used herein the term "Registrable
Security" means the Securities until (i) all Securities have been disposed of
pursuant to the Registration Statement, (ii) all Securities have been sold under
circumstances under which all of the applicable conditions of Rule 144 (or any
similar provision then in force) under the Securities Act ("Rule 144") are met,
(iii) all Securities have been otherwise transferred to persons who may trade
such Securities without restriction under the Securities Act, and the Company
has delivered a new certificate or other evidence of ownership for such
Securities not bearing a restrictive legend or (iv) such time as, in the opinion
of counsel to the Company, all Securities may be sold without any time, volume
or manner limitations pursuant to Rule 144(k) (or any similar provision then in
effect) under the Securities Act. The term "Registrable Securities" means any
and/or all of the securities falling within the foregoing definition of a
"Registrable Security." In the event of any merger, reorganization,
consolidation, recapitalization or other change in corporate structure affecting
the Common Stock, such adjustment shall be deemed to be made in the definition
of "Registrable Security" as is appropriate in order to prevent any dilution or
enlargement of the rights granted pursuant to this Agreement.

     Section 2. Restrictions on Transfer. The Purchaser acknowledges and
understands that in the absence of an effective Registration Statement
authorizing the resale of the Securities as provided herein, the Securities are
"restricted securities" as defined in Rule 144 promulgated under the Act. The
Purchaser understands that no disposition or transfer of the Securities may be
made by Purchaser in the absence of (i) an opinion of counsel to the Purchaser,
in form and substance reasonably satisfactory to the Company, that such transfer
may be made without registration under the Securities Act or (ii) such
registration.


                                      E-26
<PAGE>   2

     With a view to making available to the Purchaser the benefits of Rule 144
under the Securities Act or any other similar rule or regulation of the
Commission that may at any time permit the Purchaser to sell securities of the
Company to the public without registration ("Rule 144"), the Company agrees to:

     (a)  comply with the provisions of paragraph (c)(1) of Rule 144; and

     (b)  file with the Commission in a timely manner all reports and other
          documents required to be filed by the Company pursuant to Section 13
          or 15(d) under the Exchange Act; and, if at any time it is not
          required to file such reports but in the past had been required to or
          did file such reports, it will, upon the request of any Purchaser,
          make available other information as required by, and so long as
          necessary to permit sales of, its Registrable Securities pursuant to
          Rule 144.

     Section 3. Registration Rights With Respect to the Securities.

          (a) The Company agrees that it will prepare and file with the
Securities and Exchange Commission ("Commission"), within forty-five (45) days
after the date hereof, a registration statement (on Form F-3 and/or F-1, or
other appropriate form of registration statement) under the Securities Act (the
"Registration Statement"), at the sole expense of the Company (except as
provided in Section 3(c) hereof), in respect of Purchaser, so as to permit a
public offering and resale of the Securities under the Act by Purchaser.

          The Company shall use its best efforts to cause the Registration
Statement to become effective within five (5) days of SEC clearance to request
acceleration of effectiveness, and in no event later than February 14, 2000. If
the Registration Statement is not declared effective by April 15, 2000 this
Agreement and the Purchase Agreement shall terminate and the Company shall pay
Purchaser the sum of $50,000 as liquidated damages. The Company will notify
Purchaser of the effectiveness of the Registration Statement within one Trading
Day of such event.

          (b) The Company will maintain the Registration Statement or
post-effective amendment filed under this Section 3 hereof effective under the
Securities Act until the earlier of (i) the date that none of the Securities are
or may become issued and outstanding, (ii) the date that all of the Securities
have been sold pursuant to the Registration Statement, (iii) the date the
holders thereof receive an opinion of counsel to the Company, which counsel
shall be reasonably acceptable to the Purchaser, that the Securities may be sold
under the provisions of Rule 144 without limitation as to volume, (iv) all
Securities have been otherwise transferred to persons who may trade such shares
without restriction under the Securities Act, and the Company has delivered a
new certificate or other evidence of ownership for such securities not bearing a
restrictive legend, or (v) all Securities may be sold without any time, volume
or manner limitations pursuant to Rule 144(k) or any similar provision then in
effect under the Securities Act in the opinion of counsel to the Company, which
counsel shall be reasonably acceptable to the Purchaser (the "Effectiveness
Period").


                                      E-27
<PAGE>   3

          (c) All fees, disbursements and out-of-pocket expenses and costs
incurred by the Company in connection with the preparation and filing of the
Registration Statement under subparagraph 3(a) and in complying with applicable
securities and Blue Sky laws (including, without limitation, all attorneys' fees
of the Company) shall be borne by the Company. The Purchaser shall bear the cost
of underwriting and/or brokerage discounts, fees and commissions, if any,
applicable to the Securities being registered and the fees and expenses of its
counsel. The Purchaser and its counsel shall have a reasonable period, not to
exceed ten (10) Trading Days, to review the proposed Registration Statement or
any amendment thereto, prior to filing with the Commission, and the Company
shall provide each Purchaser with copies of any comment letters received from
the Commission with respect thereto within two (2) Trading Days of receipt
thereof. The Company shall make reasonably available for inspection by
Purchaser, any underwriter participating in any disposition pursuant to the
Registration Statement, and any attorney, accountant or other agent retained by
such Purchaser or any such underwriter all relevant financial and other records,
pertinent corporate documents and properties of the Company and its
subsidiaries, and cause the Company's officers, directors and employees to
supply all information reasonably requested by such Purchaser or any such
underwriter, attorney, accountant or agent in connection with the Registration
Statement, in each case, as is customary for similar due diligence examinations;
provided, however, that all records, information and documents that are
designated in writing by the Company, in good faith, as confidential,
proprietary or containing any material non-public information shall be kept
confidential by such Purchaser and any such underwriter, attorney, accountant or
agent (pursuant to an appropriate confidentiality agreement in the case of any
such Purchaser or agent), unless such disclosure is made pursuant to judicial
process in a court proceeding (after first giving the Company an opportunity
promptly to seek a protective order or otherwise limit the scope of the
information sought to be disclosed) or is required by law, or such records,
information or documents become available to the public generally or through a
third party not in violation of an accompanying obligation of confidentiality;
and provided further that, if the foregoing inspection and information gathering
would otherwise disrupt the Company's conduct of its business, such inspection
and information gathering shall, to the maximum extent possible, be coordinated
on behalf of the Purchaser and the other parties entitled thereto by one firm of
counsel designed by and on behalf of the majority in interest of Purchaser and
other parties. The Company shall qualify any of the securities for sale in such
states as such Purchaser reasonably designates and shall furnish indemnification
in the manner provided in Section 6 hereof. However, the Company shall not be
required to qualify in any state which will require an escrow or other
restriction relating to the Company and/or the sellers, or which will require
the Company to qualify to do business in such state or require the Company to
file therein any general consent to service of process. The Company at its
expense will supply the Purchaser with copies of the Registration Statement and
the prospectus included therein and other related documents in such quantities
as may be reasonably requested by the Purchaser.

          (d) The Company shall not be required by this Section 3 to include a
Purchaser's Securities in any Registration Statement which is to be filed if, in
the opinion of counsel for both the Purchaser and the Company (or, should they
not agree, in the opinion of another counsel experienced in securities law
matters acceptable to counsel for the Purchaser and the Company) the proposed
offering or other transfer as to which such registration is requested is exempt
from applicable federal and state securities laws and would result in all
purchasers or transferees obtaining securities which are not "restricted
securities", as defined in Rule 144 under the Securities Act.


                                      E-28
<PAGE>   4

          (e) If at any time or from time to time after the effective date of
the Registration Statement, the Company notifies the Purchaser in writing of the
existence of a Potential Material Event (as defined in Section 3(f) below), the
Purchaser shall not offer or sell any Securities or engage in any other
transaction involving or relating to Securities, from the time of the giving of
notice with respect to a Potential Material Event until such Purchaser receives
written notice from the Company that such Potential Material Event either has
been disclosed to the public or no longer constitutes a Potential Material
Event; provided, however, that if the Company so suspends the right to such
holders of Securities for more than twenty (20) days in the aggregate during any
twelve month period, during the periods the Registration Statement is required
to be in effect then the Company must compensate the Purchaser for any decline
in market value of the Securities held by Purchaser at the beginning of such
suspension through the end of such suspension. If a Potential Material Event
shall occur prior to the date the Registration Statement is filed, then the
Company's obligation to file the Registration Statement shall be delayed without
penalty for not more than thirty (30) days. The Company must give Purchaser
notice in writing at least two (2) Trading Days prior to the first day of the
blackout period, if lawful to do so.

          (f) "Potential Material Event" means any of the following: (a) the
possession by the Company of material information that is not ripe for
disclosure in a registration statement, as determined in good faith by the Chief
Executive Officer or the Board of Directors of the Company or that disclosure of
such information in the Registration Statement would be detrimental to the
business and affairs of the Company; or (b) any material engagement or activity
by the Company which would, in the good faith determination of the Chief
Executive Officer or the Board of Directors of the Company, be adversely
affected by disclosure in a registration statement at such time, which
determination shall be accompanied by a good faith determination by the Chief
Executive Officer or the Board of Directors of the Company that the Registration
Statement would be materially misleading absent the inclusion of such
information.

     Section 4. Cooperation with Company. Purchaser will cooperate with the
Company in all respects in connection with this Agreement, including timely
supplying all information reasonably requested by the Company (which shall
include all information regarding the Purchaser and proposed manner of sale of
the Registrable Securities required to be disclosed in the Registration
Statement) and executing and returning all documents reasonably requested in
connection with the registration and sale of the Registrable Securities and
entering into and performing its obligations under any underwriting agreement,
if the offering is an underwritten offering, in usual and customary form, with
the managing underwriter or underwriters of such underwritten offering. The
Purchaser shall consent to be named as an underwriter in the Registration
Statement. Purchaser acknowledges that in accordance with current Commission
policy, the Purchaser will be named as the underwriter of the Securities in the
Registration Statement.


                                      E-29
<PAGE>   5

     Section 5. Registration Procedures. If and whenever the Company is required
by any of the provisions of this Agreement to effect the registration of any of
the Registrable Securities under the Act, the Company shall (except as otherwise
provided in this Agreement), as expeditiously as possible, subject to the
Purchaser's assistance and cooperation as reasonably required:

          (a) (i) prepare and file with the Commission such amendments and
supplements to the Registration Statement and the prospectus used in connection
therewith as may be necessary to keep such registration statement effective and
to comply with the provisions of the Act with respect to the sale or other
disposition of all securities covered by such registration statement whenever
the Purchaser of such Registrable Securities shall desire to sell or otherwise
dispose of the same (including prospectus supplements with respect to the sales
of securities from time to time in connection with a registration statement
pursuant to Rule 415 promulgated under the Act) and (ii) take all lawful action
such that each of (A) the Registration Statement and any amendment thereto does
not, when it becomes effective, contain an untrue statement of a material fact
or omit to state a material fact required to be stated therein or necessary to
make the statements therein, not misleading and (B) the Prospectus forming part
of the Registration Statement, and any amendment or supplement thereto, does not
at any time during the Registration Period include an untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading.

          (b) (i) prior to the filing with the Commission of any Registration
Statement (including any amendments thereto) and the distribution or delivery of
any prospectus (including any supplements thereto), provide draft copies thereof
to the Purchasers and reflect in such documents all such comments as the
Purchasers (and their counsel) reasonably may propose and (ii) furnish to each
Purchaser such numbers of copies of a prospectus including a preliminary
prospectus or any amendment or supplement to any prospectus, as applicable, in
conformity with the requirements of the Act, and such other documents, as such
Purchaser may reasonably request in order to facilitate the public sale or other
disposition of the securities owned by such Purchaser;

          (c) (i) register and qualify the Registrable Securities covered by the
Registration Statement under such other securities or blue sky laws of such
jurisdictions as the Purchaser shall reasonably request (subject to the
limitations set forth in Section 3(d) above), and do any and all other acts and
things which may be necessary or advisable to enable each Purchaser to
consummate the public sale or other disposition in such jurisdiction of the
securities owned by such Purchaser, except that the Company shall not for any
such purpose be required to qualify to do business as a foreign corporation in
any jurisdiction wherein it is not so qualified or to file therein any general
consent to service of process;

          (d) list such Registrable Securities on the Principal Market, and any
other exchange on which the Common Stock of the Company is then listed, if the
listing of such Registrable Securities is then permitted under the rules of such
exchange or the Nasdaq Stock Market;


                                      E-30
<PAGE>   6

          (e) notify each Purchaser at any time when a prospectus relating
thereto covered by the Registration Statement is required to be delivered under
the Act, of the happening of any event of which it has knowledge as a result of
which the prospectus included in the Registration Statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading in the light of the circumstances then existing, and the Company
shall prepare and file a curative amendment under Section 5(a) as quickly as
commercially possible;

          (f) as promptly as practicable after becoming aware of such event,
notify each Purchaser who holds Registrable Securities being sold (or, in the
event of an underwritten offering, the managing underwriters) of the issuance by
the Commission or any state authority of any stop order or other suspension of
the effectiveness of the Registration Statement at the earliest possible time
and take all lawful action to effect the withdrawal, recession or removal of
such stop order or other suspension;

          (g) cooperate with the Purchasers to facilitate the timely preparation
and delivery of certificates for the Registrable Securities to be offered
pursuant to the Registration Statement and enable such certificates for the
Registrable Securities to be in such denominations or amounts, as the case may
be, as the Purchasers reasonably may request and registered in such names as the
Purchaser may request; and, within three (3) Trading Days after a Registration
Statement which includes Registrable Securities is declared effective by the
Commission, deliver and cause legal counsel selected by the Company to deliver
to the transfer agent for the Registrable Securities (with copies to the
Purchasers whose Registrable Securities are included in such Registration
Statement) an appropriate instruction and, to the extent necessary, an opinion
of such counsel;

          (h) take all such other lawful actions reasonably necessary to
expedite and facilitate the disposition by the Purchasers of their Registrable
Securities in accordance with the intended methods therefor provided in the
prospectus which are customary for issuers to perform under the circumstances;

          (i) in the event of an underwritten offering, promptly include or
incorporate in a Prospectus supplement or post-effective amendment to the
Registration Statement such information as the managers reasonably agree should
be included therein and to which the Company does not reasonably object and make
all required filings of such Prospectus supplement or post-effective amendment
as soon as practicable after it is notified of the matters to be included or
incorporated in such Prospectus supplement or post-effective amendment; and

          (j) maintain a transfer agent and registrar for its Common Stock.


                                      E-31



<PAGE>   7

     Section 6. Indemnification.

          (a) The Company agrees to indemnify and hold harmless the Purchaser
and each person, if any, who controls the Purchaser within the meaning of the
Securities Act ("Distributing Purchaser") against any losses, claims, damages or
liabilities, joint or several (which shall, for all purposes of this Agreement,
include, but not be limited to, all reasonable costs of defense and
investigation and all reasonable attorneys' fees), to which the Distributing
Purchaser may become subject, under the Securities Act or otherwise, insofar as
such losses, claims, damages or liabilities (or actions in respect thereof)
arise out of or are based upon any untrue statement or alleged untrue statement
of any material fact contained in the Registration Statement, or any related
preliminary prospectus, final prospectus or amendment or supplement thereto, or
arise out of or are based upon the omission or alleged omission to state therein
a material fact required to be stated therein or necessary to make the
statements therein not misleading; provided, however, that the Company will not
be liable in any such case to the extent that any such loss, claim, damage or
liability arises out of or is based upon an untrue statement or alleged untrue
statement or omission or alleged omission made in the Registration Statement,
preliminary prospectus, final prospectus or amendment or supplement thereto in
reliance upon, and in conformity with, written information furnished to the
Company by the Distributing Purchaser, specifically for use in the preparation
thereof. This Section 6(a) shall not inure to the benefit of any Distributing
Purchaser with respect to any person asserting such loss, claim, damage or
liability who purchased the Registrable Securities which are the subject thereof
if the Distributing Purchaser failed to send or give (in violation of the
Securities Act or the rules and regulations promulgated thereunder) a copy of
the prospectus contained in such Registration Statement to such person at or
prior to the written confirmation to such person of the sale of such Registrable
Securities, where the Distributing Purchaser was obligated to do so under the
Securities Act or the rules and regulations promulgated thereunder. This
indemnity agreement will be in addition to any liability which the Company may
otherwise have.

          (b) Each Distributing Purchaser agrees that it will indemnify and hold
harmless the Company, and each officer, director of the Company or person, if
any, who controls the Company within the meaning of the Securities Act, against
any losses, claims, damages or liabilities (which shall, for all purposes of
this Agreement, include, but not be limited to, all reasonable costs of defense
and investigation and all reasonable attorneys' fees) to which the Company or
any such officer, director or controlling person may become subject under the
Securities Act or otherwise, insofar as such losses, claims, damages or
liabilities (or actions in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained in
the Registration Statement, or any related preliminary prospectus, final
prospectus or amendment or supplement thereto, or arise out of or are based upon
the omission or the alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
but in each case only to the extent that such untrue statement or alleged untrue
statement or omission or alleged omission was made in the Registration
Statement, preliminary prospectus, final prospectus or amendment or supplement
thereto in reliance upon, and in conformity with, written information furnished
to the Company by such Distributing Purchaser, specifically for use in the
preparation thereof. This indemnity agreement will be in addition to any
liability which the Distributing Purchaser may otherwise have.


                                      E-32



<PAGE>   8

          (c) Promptly after receipt by an indemnified party under this Section
6 of notice of the commencement of any action, such indemnified party will, if a
claim in respect thereof is to be made against the indemnifying party under this
Section 6, notify the indemnifying party of the commencement thereof; but the
omission so to notify the indemnifying party will not relieve the indemnifying
party from any liability which it may have to any indemnified party except to
the extent of actual prejudice demonstrated by the indemnifying party. In case
any such action is brought against any indemnified party, and it notifies the
indemnifying party of the commencement thereof, the indemnifying party will be
entitled to participate in, and, to the extent that it may wish, jointly with
any other indemnifying party similarly notified, assume the defense thereof,
subject to the provisions herein stated and after notice from the indemnifying
party to such indemnified party of its election so to assume the defense
thereof, the indemnifying party will not be liable to such indemnified party
under this Section 6 for any legal or other expenses subsequently incurred by
such indemnified party in connection with the defense thereof other than
reasonable costs of investigation, unless the indemnifying party shall not
pursue the action to its final conclusion. The indemnified party shall have the
right to employ separate counsel in any such action and to participate in the
defense thereof, but the fees and expenses of such counsel shall not be at the
expense of the indemnifying party if the indemnifying party has assumed the
defense of the action with counsel reasonably satisfactory to the indemnified
party; provided that if the indemnified party is the Distributing Purchaser, the
fees and expenses of such counsel shall be at the expense of the indemnifying
party if (i) the employment of such counsel has been specifically authorized in
writing by the indemnifying party, or (ii) the named parties to any such action
(including any impleaded parties) include both the Distributing Purchaser and
the indemnifying party and the Distributing Purchaser shall have been advised by
such counsel that there may be one or more legal defenses available to the
indemnifying party different from or in conflict with any legal defenses which
may be available to the Distributing Purchaser (in which case the indemnifying
party shall not have the right to assume the defense of such action on behalf of
the Distributing Purchaser, it being understood, however, that the indemnifying
party shall, in connection with any one such action or separate but
substantially similar or related actions in the same jurisdiction arising out of
the same general allegations or circumstances, be liable only for the reasonable
fees and expenses of one separate firm of attorneys for the Distributing
Purchaser, which firm shall be designated in writing by the Distributing
Purchaser). No settlement of any action against an indemnified party shall be
made without the prior written consent of the indemnified party, which consent
shall not be unreasonably withheld.

     Section 7. Contribution. In order to provide for just and equitable
contribution under the Securities Act in any case in which (i) the indemnified
party makes a claim for indemnification pursuant to Section 6 hereof but is
judicially determined (by the entry of a final judgment or decree by a court of
competent jurisdiction and the expiration of time to appeal or the denial of the
last right of appeal) that such indemnification may not be enforced in such case
notwithstanding the fact that the express provisions of Section 6 hereof provide
for indemnification in such case, or (ii) contribution under the Securities Act
may be required on the part of any indemnified party, then the Company and the
applicable Distributing Purchaser shall contribute to the aggregate losses,
claims, damages or liabilities to which they may be subject (which shall, for
all purposes of this Agreement, include, but not be limited to, all reasonable
costs of defense and investigation and all reasonable attorneys' fees), in
either such case (after contribution from others) on the basis of relative fault
as well as any other relevant equitable considerations. The relative fault shall
be determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission or alleged omission to state
a material fact relates to information supplied by the Company on the one hand
or the applicable Distributing Purchaser on the other hand, and the parties'
relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission. The Company and the Distributing Purchaser
agree that it would not be just and equitable if contribution pursuant to this
Section 7 were determined by pro rata allocation or by any other method of
allocation which does not take account of the equitable considerations referred
to in this Section 7. The amount paid or payable by an indemnified party as a
result of the losses, claims, damages or liabilities (or actions in respect
thereof) referred to above in this Section 7 shall be deemed to include any
legal or other expenses reasonably incurred by such indemnified party in
connection with investigating or defending any such action or claim. No person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) shall be entitled to contribution from any person who was
not guilty of such fraudulent misrepresentation.


                                      E-33



<PAGE>   9

     Notwithstanding any other provision of this Section 7, in no event shall
any (i) Purchaser be required to undertake liability to any person under this
Section 7 for any amounts in excess of the dollar amount of the net proceeds to
be received by such Purchaser from the sale of such Purchaser's Registrable
Securities (after deducting any fees, discounts and commissions applicable
thereto) pursuant to any Registration Statement under which such Registrable
Securities are to be registered under the Securities Act and (ii) underwriter be
required to undertake liability to any person hereunder for any amounts in
excess of the aggregate discount, commission or other compensation payable to
such underwriter with respect to the Registrable Securities underwritten by it
and distributed pursuant to the Registration Statement.

     Section 8. Notices. All notices, demands, requests, consents, approvals,
and other communications required or permitted hereunder shall be in writing
and, unless otherwise specified herein, shall be delivered as set forth in the
Purchase Agreement.

     Section 9. Assignment. Neither this Agreement nor any rights of the
Purchaser or the Company hereunder may be assigned by either party to any other
person. Notwithstanding the foregoing, (a) the provisions of this Agreement
shall inure to the benefit of, and be enforceable by, any transferee of any of
the Common Stock purchased by the Purchaser pursuant to the Purchase Agreement
other than through open-market sales, and (b) upon the prior written consent of
the Company, which consent shall not be unreasonably withheld or delayed in the
case of an assignment to an affiliate of the Purchaser, the Purchaser's interest
in this Agreement may be assigned at any time, in whole or in part, to any other
person or entity (including any affiliate of the Purchaser) who agrees to be
bound hereby.

     Section 10. Counterparts/Facsimile. This Agreement may be executed in two
or more counterparts, each of which shall constitute an original, but all of
which, when together shall constitute but one and the same instrument, and shall
become effective when one or more counterparts have been signed by each party
hereto and delivered to the other party. In lieu of the original, a facsimile
transmission or copy of the original shall be as effective and enforceable as
the original.


                                      E-34



<PAGE>   10

     Section 11. Remedies. The remedies provided in this Agreement are
cumulative and not exclusive of any remedies provided by law. If any term,
provision, covenant or restriction of this Agreement is held by a court of
competent jurisdiction to be invalid, illegal, void or unenforceable, the
remainder of the terms, provisions, covenants and restrictions set forth herein
shall remain in full force and effect and shall in no way be affected, impaired
or invalidated, and the parties hereto shall use their best efforts to find and
employ an alternative means to achieve the same or substantially the same result
as that contemplated by such term, provision, covenant or restriction. It is
hereby stipulated and declared to be the intention of the parties that they
would have executed the remaining terms, provisions, covenants and restrictions
without including any of such that may be hereafter declared invalid, illegal,
void or unenforceable.

     Section 12. Conflicting Agreements. The Company shall not enter into any
agreement with respect to its securities that is inconsistent with the rights
granted to the holders of Registrable Securities in this Agreement or otherwise
prevents the Company from complying with all of its obligations hereunder.

     Section 13. Headings. The headings in this Agreement are for reference
purposes only and shall not affect in any way the meaning or interpretation of
this Agreement.

     Section 14. Governing Law. This Agreement shall be governed by and
construed in accordance with the laws of the State of New York applicable to
contracts made in New York by persons domiciled in New York City and without
regard to its principles of conflicts of laws. Any action may be brought as set
forth in the Purchase Agreement. Any party shall have the right to seek
injunctive relief from any court of competent jurisdiction in any case where
such relief is available.

     Section 15. Severability. If any provision of this Agreement shall for any
reason be held invalid or unenforceable, such invalidity or unenforceablity
shall not affect any other provision hereof and this Agreement shall be
construed as if such invalid or unenforceable provision had never been contained
herein. Terms not otherwise defined herein shall be defined in accordance with
the Agreement.


                                      E-35



<PAGE>   11


          IN WITNESS WHEREOF, the parties hereto have caused this Registration
Rights Agreement to be duly executed, on the day and year first above written.

                    NYMOX PHARMACEUTICAL CORPORATION

                    By: /s/ Paul Averback
                       ---------------------------------
                       Dr. Paul Averback, President

                    Jaspas Investments Limited

                    By: /s/ Hans Gassner
                       ----------------------------------
                       Hans Gassner, Authorized Signatory


                                      E-36




<PAGE>   1



EXHIBIT 2.2

                                ESCROW AGREEMENT

     THIS ESCROW AGREEMENT (this "Agreement") is made as of November 1, 1999, by
and among Nymox Pharmaceutical Corporation, a corporation incorporated under the
laws of Canada, (the "Company"), Jaspas Investments Limited ("Purchaser"), and
Epstein Becker & Green, P.C., having an address at 250 Park Avenue, New York, NY
10177 (the "Escrow Agent"). Capitalized terms used but not defined herein shall
have the meanings set forth in the Common Stock Purchase Agreement referred to
in the first recital.

     WHEREAS, the Purchaser will from time to time as requested by the Company,
purchase shares of the Company's Common Stock from the Company as set forth in
that certain Common Stock Purchase Agreement (the "Purchase Agreement") dated
the date hereof between the Purchaser and the Company, which will be issued as
per the terms and conditions contained herein and in the Purchase Agreement; and

     WHEREAS, the Company and the Purchaser have requested that the Escrow Agent
hold in escrow and then distribute the initial documents and certain funds which
are conditions precedent to the effectiveness of the Purchase Agreement, and
have further requested that upon each exercise of a Draw Down, the Escrow Agent
hold the relevant documents and the applicable purchase price pending receipt by
Purchaser of certificates representing the securities issuable upon such Draw
Down;

     NOW, THEREFORE, in consideration of the covenants and mutual promises
contained herein and other good and valuable consideration, the receipt and
legal sufficiency of which are hereby acknowledged and intending to be legally
bound hereby, the parties agree as follows:

                                    ARTICLE I

                   TERMS OF THE ESCROW FOR THE INITIAL CLOSING

     1.1 The parties hereby agree to establish an escrow account with the Escrow
Agent whereby the Escrow Agent shall hold the funds and documents which are
referenced in Section 5.2 of the Purchase Agreement.

     1.2 At the Closing, the Company shall deliver to the Escrow Agent:

         (i)  the original executed Registration Rights Agreement in the form of
              Exhibit A to the Purchase Agreement;

         (ii) the original executed opinion of Foley & Lardner, in the form of
              Exhibit C to the Purchase Agreement;


                                      E-37



<PAGE>   2

     (iii) the sum of $35,000;

     (iv)  the original executed Company counterpart of this Escrow Agreement;

     (v)   the original executed Company counterpart of the Purchase Agreement;
           and

     (vi)  the certificate representing the Warrants.

     1.3 Upon receipt of the foregoing, and receipt of executed counterparts
from Purchaser of the Purchase Agreement, the Registration Rights Agreement and
this Escrow Agreement, the Escrow Agent shall immediately transfer the sum of
thirty-five thousand dollars ($35,000) to Epstein Becker & Green, P.C. ("EB&G"),
250 Park Avenue, New York, New York 10177 for the Purchaser's legal,
administrative and escrow costs, and which sum shall also encompass the ordinary
services of the Escrow Agent for each closing of a Draw Down, and the Escrow
Agent shall then arrange to have the Purchase Agreement, this Escrow Agreement,
the Registration Rights Agreement, the Warrants and the opinion of counsel
delivered to the appropriate parties.

                                   ARTICLE II

                     TERMS OF THE ESCROW FOR EACH DRAW DOWN

     2.1 Each time the Company shall send a Draw Down Notice to the Purchaser as
provided in the Purchase Agreement, it shall send a copy, by facsimile, to the
Escrow Agent.

     2.2 Each time the Purchaser shall purchase Shares pursuant to a Draw Down,
the Purchaser shall send the applicable purchase price of the Draw Down Shares
to the Escrow Agent, which shall advise the Company in writing that it has
received the purchase price for such Draw Down Shares. The Company shall
promptly, but no later than three (3) Trading Days after receipt of such funding
notice from the Escrow Agent, cause its transfer agent to issue the Draw Down
Shares to the Purchaser via DTC deposit to the account specified by the
Purchaser from time to time. Upon receipt of written confirmation from the
transfer agent or from the Purchaser that such Draw Down Shares have been so
deposited, the Escrow Agent shall within one (1) Trading Day wire 97% of the
purchase price per the written instructions of the Company and the remaining 3%
of the purchase price as directed by the placement agent identified to the
Escrow Agent by the Purchaser.


                                      E-38





<PAGE>   3

                                   ARTICLE III

                                  MISCELLANEOUS

     3.1 No waiver or any breach of any covenant or provision herein contained
shall be deemed a waiver of any preceding or succeeding breach thereof, or of
any other covenant or provision herein contained. No extension of time for
performance of any obligation or act shall be deemed an extension of the time
for performance of any other obligation or act.

     3.2 All notices or other communications required or permitted hereunder
shall be in writing, and shall be sent by fax, overnight courier, registered or
certified mail, postage prepaid, return receipt requested, and shall be deemed
received upon receipt thereof, as set forth in the Purchase Agreement.

     3.3 This Escrow Agreement shall be binding upon and shall inure to the
benefit of the permitted successors and permitted assigns of the parties hereto.

     3.4 This Escrow Agreement is the final expression of, and contains the
entire agreement between, the parties with respect to the subject matter hereof
and supersedes all prior understandings with respect thereto. This Escrow
Agreement may not be modified, changed, supplemented or terminated, nor may any
obligations hereunder be waived, except by written instrument signed by the
parties to be charged or by their respective agents duly authorized in writing
or as otherwise expressly permitted herein.

     3.5 Whenever required by the context of this Escrow Agreement, the singular
shall include the plural and masculine shall include the feminine. This Escrow
Agreement shall not be construed as if it had been prepared by one of the
parties, but rather as if both parties had prepared the same. Unless otherwise
indicated, all references to Articles are to this Escrow Agreement.

     3.6 The parties hereto expressly agree that this Escrow Agreement shall be
governed by, interpreted under and construed and enforced in accordance with the
laws of the State of New York. Except as expressly set forth herein, any action
to enforce, arising out of, or relating in any way to, any provisions of this
Escrow Agreement shall brought in the Federal or state courts of New York, New
York as is more fully set forth in the Purchase Agreement.

     3.7 The Escrow Agent's duties hereunder may be altered, amended, modified
or revoked only by a writing signed by the Company, Purchaser and the Escrow
Agent.

     3.8 The Escrow Agent shall be obligated only for the performance of such
duties as are specifically set forth herein and may rely and shall be protected
in relying or refraining from acting on any instrument reasonably believed by
the Escrow Agent to be genuine and to have been signed or presented by the
proper party or parties. The Escrow Agent shall not be personally liable for any
act the Escrow Agent may do or omit to do hereunder as the Escrow Agent while
acting in good faith, excepting only its own gross negligence or willful
misconduct, and any act done or omitted by the Escrow Agent pursuant to the
advice of the Escrow Agent's attorneys-at-law (other than Escrow Agent itself)
shall be conclusive evidence of such good faith.


                                      E-39





<PAGE>   4

     3.9 The Escrow Agent is hereby expressly authorized to disregard any and
all warnings given by any of the parties hereto or by any other person or
corporation, excepting only orders or process of courts of law and is hereby
expressly authorized to comply with and obey orders, judgments or decrees of any
court. In case the Escrow Agent obeys or complies with any such order, judgment
or decree, the Escrow Agent shall not be liable to any of the parties hereto or
to any other person, firm or corporation by reason of such decree being
subsequently reversed, modified, annulled, set aside, vacated or found to have
been entered without jurisdiction.

     3.10 The Escrow Agent shall not be liable in any respect on account of the
identity, authorization or rights of the parties executing or delivering or
purporting to execute or deliver the Purchase Agreement or any documents or
papers deposited or called for thereunder or hereunder.

     3.11 The Escrow Agent shall be entitled to employ such legal counsel and
other experts as the Escrow Agent may deem necessary properly to advise the
Escrow Agent in connection with the Escrow Agent's duties hereunder, may rely
upon the advice of such counsel, and may pay such counsel reasonable
compensation therefor. THE ESCROW AGENT HAS ACTED AS LEGAL COUNSEL FOR THE
PURCHASER, AND MAY CONTINUE TO ACT AS LEGAL COUNSEL FOR THE PURCHASER, FROM TIME
TO TIME, NOTWITHSTANDING ITS DUTIES AS THE ESCROW AGENT HEREUNDER. THE COMPANY
CONSENTS TO THE ESCROW AGENT IN SUCH CAPACITY AS LEGAL COUNSEL FOR THE PURCHASER
AND WAIVES ANY CLAIM THAT SUCH REPRESENTATION REPRESENTS A CONFLICT OF INTEREST
ON THE PART OF THE ESCROW AGENT. THE COMPANY UNDERSTANDS THAT THE PURCHASER AND
THE ESCROW AGENT ARE RELYING EXPLICITLY ON THE FOREGOING PROVISION IN ENTERING
INTO THIS ESCROW AGREEMENT.

     3.12 The Escrow Agent's responsibilities as escrow agent hereunder shall
terminate if the Escrow Agent shall resign by written notice to the Company and
the Purchaser. In the event of any such resignation, the Purchaser and the
Company shall appoint a successor Escrow Agent.

     3.13 If the Escrow Agent reasonably requires other or further instruments
in connection with this Escrow Agreement or obligations in respect hereto, the
necessary parties hereto shall join in furnishing such instruments.

     3.14 It is understood and agreed that should any dispute arise with respect
to the delivery and/or ownership or right of possession of the documents or the
escrow funds held by the Escrow Agent hereunder, the Escrow Agent is authorized
and directed in the Escrow Agent's sole discretion (1) to retain in the Escrow
Agent's possession without liability to anyone all or any part of said documents
or the escrow funds until such disputes shall have been settled either by mutual
written agreement of the parties concerned by a final order, decree or judgment
or a court of competent jurisdiction after the time for appeal has expired and
no appeal has been perfected, but the Escrow Agent shall be under no duty
whatsoever to institute or defend any such proceedings or (2) to deliver the
escrow funds and any other property and documents held by the Escrow Agent
hereunder to a state or Federal court having competent subject matter
jurisdiction and located in the State and City of New York in accordance with
the applicable procedure therefor.


                                      E-40



<PAGE>   5

     3.15 The Company and the Purchaser agree jointly and severally to indemnify
and hold harmless the Escrow Agent and its partners, employees, agents and
representatives from any and all claims, liabilities, costs or expenses in any
way arising from or relating to the duties or performance of the Escrow Agent
hereunder or the transactions contemplated hereby or by the Purchase Agreement
other than any such claim, liability, cost or expense to the extent the same
shall have been determined by final, unappealable judgment of a court of
competent jurisdiction to have resulted from the gross negligence or willful
misconduct of the Escrow Agent.

     IN WITNESS WHEREOF, the parties hereto have executed this Escrow Agreement
as of the date set forth above.


Nymox Pharmaceutical Corporation

By: /s/ Paul Averback
    -----------------------------------
    Dr. Paul Averback, President


Jaspas Investments Limited

By: /s/ Hans Gassner
    -----------------------------------
    Hans Gassner, Authorized Signatory


Escrow Agent
Epstein Becker & Green, P.C.

By: /s/ Joseph A. Smith
    ------------------------------------
    Joseph A. Smith,
    Authorized Signatory


                                      E-41




<PAGE>   1



EXHIBIT 2.3

NEITHER THIS WARRANT NOR THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT")
OR ANY OTHER APPLICABLE UNITED STATES OR CANADIAN SECURITIES LAWS IN RELIANCE
UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND
SUCH OTHER SECURITIES LAWS. NEITHER THIS WARRANT NOR THE SHARES ISSUABLE UPON
EXERCISE HEREOF MAY BE SOLD, PLEDGED, TRANSFERRED, ENCUMBERED OR OTHERWISE
DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OR IN A TRANSACTION WHICH IS EXEMPT FROM REGISTRATION UNDER THE
PROVISIONS OF THE SECURITIES ACT OR ANY APPLICABLE CANADIAN LAWS.

                             STOCK PURCHASE WARRANT

                  To Purchase 200,000 Shares of Common Stock of

                        Nymox Pharmaceutical Corporation

         THIS CERTIFIES that, for value received, Jaspas Investments Limited
(the "Holder"), is entitled, upon the terms and subject to the limitations on
exercise and the conditions hereinafter set forth, at any time on or after
November 30, 1999 (the "Initial Exercise Date") and on or prior to the close of
business on November 30, 2004 (the "Termination Date") but not thereafter, to
subscribe for and purchase from Nymox Pharmaceutical Corporation, a corporation
incorporated in Canada (the "Company"), up to Two Hundred Thousand (200,000)
shares (the "Warrant Shares") of Common Stock, no par value, of the Company (the
"Common Stock"). The purchase price of one share of Common Stock (the "Exercise
Price") under this Warrant shall be $4.5315. The Exercise Price and the number
of shares for which the Warrant is exercisable shall be subject to adjustment as
provided herein. In the event of any conflict between the terms of this Warrant
and the Common Stock Purchase Agreement dated as of November 1, 1999 pursuant to
which this Warrant has been issued (the "Purchase Agreement"), the Purchase
Agreement shall control. Capitalized terms used and not otherwise defined herein
shall have the meanings set forth for such terms in the Purchase Agreement.


                                      E-42



<PAGE>   2



     1. Title to Warrant. Prior to the Termination Date and subject to
compliance with applicable laws, this Warrant and all rights hereunder are
transferable, in whole or in part, at the office or agency of the Company by the
holder hereof in person or by duly authorized attorney, upon surrender of this
Warrant together with the Assignment Form annexed hereto properly endorsed.

     2. Authorization of Shares. The Company covenants that all shares of Common
Stock which may be issued upon the exercise of rights represented by this
Warrant will, upon exercise of the rights represented by this Warrant, be duly
authorized, validly issued, fully paid and nonassessable and free from all
taxes, liens and charges in respect of the issue thereof (other than taxes in
respect of any transfer occurring contemporaneously with such issue).

     3. Exercise of Warrant. (a) Except as provided in Section 4 herein,
exercise of the purchase rights represented by this Warrant may be made at any
time or times on or after the Initial Exercise Date, and before the close of
business on the Termination Date as to One Hundred Thousand (100,000) shares by
the surrender of this Warrant and the Notice of Exercise Form annexed hereto
duly executed, at the office of the Company (or such other office or agency of
the Company as it may designate by notice in writing to the registered holder
hereof at the address of such holder appearing on the books of the Company) and
upon payment of the Exercise Price of the shares thereby purchased by wire
transfer or cashier's check drawn on a United States or Canadian bank, the
holder of this Warrant shall be entitled to receive a certificate for the number
of shares of Common Stock so purchased. Certificates for shares purchased
hereunder shall be delivered to the holder hereof within three (3) Trading Days
after the date on which this Warrant shall have been exercised as aforesaid.
This Warrant shall be deemed to have been exercised and such certificate or
certificates shall be deemed to have been issued, and Holder or any other person
so designated to be named therein shall be deemed to have become a holder of
record of such shares for all purposes, as of the date the Warrant has been
exercised by payment to the Company of the Exercise Price and all taxes required
to be paid by Holder, if any, pursuant to Section 5 prior to the issuance of
such shares, have been paid. This Warrant may be exercised a to the remaining
One Hundred Thousand (100,000) shares if and only if the Company shall not have
properly issued Draw Down Notices pursuant to the Purchase Agreement aggregating
Seven Million Dollars ($7,000,000) on or before the date which is eighteen
months from the Effective Date.

          (b) If this Warrant shall have been exercised in part, the Company
shall, at the time of delivery of the certificate or certificates representing
Warrant Shares, deliver to Holder a new Warrant evidencing the rights of Holder
to purchase the unpurchased shares of Common Stock called for by this Warrant,
which new Warrant shall in all other respects be identical with this Warrant.

          (c) If no registration statement is effective permitting the resale of
the shares of Common Stock issued upon exercise of this Warrant at any time
commencing one year after the issuance date hereof, then this Warrant shall also
be exercisable by means of a "cashless exercise" in which the holder shall be
entitled to receive a certificate for the number of shares equal to the quotient
obtained by dividing [(A-B) (X)] by (A), where:


                                      E-43



<PAGE>   3

(A) = the average of the high and low trading prices per share of Common Stock
on the Trading Day preceding the date of such election on the Nasdaq Stock
Market, or if the Common Stock is not traded on the Nasdaq Stock Market, then
the principal market in terms of volume, and converted into US Dollars;

(B) = the Exercise Price of the Warrants; and

(X) = the number of shares issuable upon exercise of the Warrants in accordance
with the terms of this Warrant.

     4. No Fractional Shares or Scrip. No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of this
Warrant. As to any fraction of a share which Holder would otherwise be entitled
to purchase upon such exercise, the Company shall pay a cash adjustment in
respect of such final fraction in an amount equal to the Exercise Price.

     5. Charges, Taxes and Expenses. Issuance of certificates for shares of
Common Stock upon the exercise of this Warrant shall be made without charge to
the holder hereof for any issue or transfer tax or other incidental expense in
respect of the issuance of such certificate, all of which taxes and expenses
shall be paid by the Company, and such certificates shall be issued in the name
of the holder of this Warrant or in such name or names as may be directed by the
holder of this Warrant; provided, however, that in the event certificates for
shares of Common Stock are to be issued in a name other than the name of the
holder of this Warrant, this Warrant when surrendered for exercise shall be
accompanied by the Assignment Form attached hereto duly executed by the holder
hereof; and the Company may require, as a condition thereto, the payment of a
sum sufficient to reimburse it for any transfer tax incidental thereto.

     6. Closing of Books. The Company will not close its shareholder books or
records in any manner which prevents the timely exercise of this Warrant.

     7. Transfer, Division and Combination. (a) Subject to compliance with any
applicable securities laws, transfer of this Warrant and all rights hereunder,
in whole or in part, shall be registered on the books of the Company to be
maintained for such purpose, upon surrender of this Warrant at the principal
office of the Company, together with a written assignment of this Warrant
substantially in the form attached hereto duly executed by Holder or its agent
or attorney and funds sufficient to pay any transfer taxes payable upon the
making of such transfer. Upon such surrender and, if required, such payment, the
Company shall execute and deliver a new Warrant or Warrants in the name of the
assignee or assignees and in the denomination or denominations specified in such
instrument of assignment, and shall issue to the assignor a new Warrant
evidencing the portion of this Warrant not so assigned, and this Warrant shall
promptly be cancelled. A Warrant, if properly assigned, may be exercised by a
new holder for the purchase of shares of Common Stock without having a new
Warrant issued.

          (b) This Warrant may be divided or combined with other Warrants upon
presentation hereof at the aforesaid office of the Company, together with a
written notice specifying the names and denominations in which new Warrants are
to be issued, signed by Holder or its agent or attorney. Subject to compliance
with Section 7(a), as to any transfer which may be involved in such division or
combination, the Company shall execute and deliver a new Warrant or Warrants in
exchange for the Warrant or Warrants to be divided or combined in accordance
with such notice.


                                      E-44




<PAGE>   4

          (c) The Company shall prepare, issue and deliver at its own expense
(other than transfer taxes) the new Warrant or Warrants under this Section 7.

          (d) The Company agrees to maintain, at its aforesaid office, books for
the registration and the registration of transfer of the Warrants.

     8. No Rights as Shareholder until Exercise. This Warrant does not entitle
the holder hereof to any voting rights or other rights as a shareholder of the
Company prior to the exercise hereof. Upon the surrender of this Warrant and the
payment of the aggregate Exercise Price, the Warrant Shares so purchased shall
be and be deemed to be issued to such holder as the record owner of such shares
as of the close of business on the later of the date of such surrender or
payment.

     9. Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants
that upon receipt by the Company of evidence reasonably satisfactory to it of
the loss, theft, destruction or mutilation of this Warrant certificate or any
stock certificate relating to the Warrant Shares, and in case of loss, theft or
destruction, of indemnity or security reasonably satisfactory to it (which shall
not include the posting of any bond), and upon surrender and cancellation of
such Warrant or stock certificate, if mutilated, the Company will make and
deliver a new Warrant or stock certificate of like tenor and dated as of such
cancellation, in lieu of such Warrant or stock certificate.

     10. Saturdays, Sundays, Holidays, etc. If the last or appointed day for the
taking of any action or the expiration of any right required or granted herein
shall be a Saturday, Sunday or a legal holiday, then such action may be taken or
such right may be exercised on the next succeeding day not a Saturday, Sunday or
legal holiday.

     11. Adjustments of Exercise Price and Number of Warrant Shares. (a) Stock
Splits, etc. The number and kind of securities purchasable upon the exercise of
this Warrant and the Exercise Price shall be subject to adjustment from time to
time upon the happening of any of the following. In case the Company shall (i)
pay a dividend in shares of Common Stock or make a distribution in shares of
Common Stock to holders of its outstanding Common Stock, (ii) subdivide its
outstanding shares of Common Stock into a greater number of shares of Common
Stock, (iii) combine its outstanding shares of Common Stock into a smaller
number of shares of Common Stock or (iv) issue any shares of its capital stock
in a reclassification of the Common Stock, then the number of Warrant Shares
purchasable upon exercise of this Warrant immediately prior thereto shall be
adjusted so that the holder of this Warrant shall be entitled to receive the
kind and number of Warrant Shares or other securities of the Company which he
would have owned or have been entitled to receive had such Warrant been
exercised in advance thereof. Upon each such adjustment of the kind and number
of Warrant Shares or other securities of the Company which are purchasable
hereunder, the holder of this Warrant shall thereafter be entitled to purchase
the number of Warrant Shares or other securities resulting from such adjustment
at an Exercise Price per Warrant Share or other security obtained by multiplying
the Exercise Price in effect immediately prior to such adjustment by the number
of Warrant Shares purchasable pursuant hereto immediately prior to such
adjustment and dividing by the number of Warrant Shares or other securities of
the Company resulting from such adjustment. An adjustment made pursuant to this
paragraph shall become effective immediately after the effective date of such
event retroactive to the record date, if any, for such event.


                                      E-45



<PAGE>   5

          (b) Reorganization, Reclassification, Merger, Consolidation or
Disposition of Assets. In case the Company shall reorganize its capital,
reclassify its capital stock, consolidate or merge with or into another
corporation (where the Company is not the surviving corporation or where there
is a change in or distribution with respect to the Common Stock of the Company),
or sell, transfer or otherwise dispose of all or substantially all its property,
assets or business to another corporation and, pursuant to the terms of such
reorganization, reclassification, merger, consolidation or disposition of
assets, shares of common stock of the successor or acquiring corporation, or any
cash, shares of stock or other securities or property of any nature whatsoever
(including warrants or other subscription or purchase rights) in addition to or
in lieu of common stock of the successor or acquiring corporation ("Other
Property"), are to be received by or distributed to the holders of Common Stock
of the Company, then Holder shall have the right thereafter to receive, upon
exercise of this Warrant, the number of shares of common stock of the successor
or acquiring corporation or of the Company, if it is the surviving corporation,
and Other Property receivable upon or as a result of such reorganization,
reclassification, merger, consolidation or disposition of assets by a holder of
the number of shares of Common Stock for which this Warrant is exercisable
immediately prior to such event. In case of any such reorganization,
reclassification, merger, consolidation or disposition of assets, the successor
or acquiring corporation (if other than the Company) shall expressly assume the
due and punctual observance and performance of each and every covenant and
condition of this Warrant to be performed and observed by the Company and all
the obligations and liabilities hereunder, subject to such modifications as may
be deemed appropriate (as determined in good faith by resolution of the Board of
Directors of the Company) in order to provide for adjustments of shares of
Common Stock for which this Warrant is exercisable which shall be as nearly
equivalent as practicable to the adjustments provided for in this Section 11.
For purposes of this Section 11, "common stock of the successor or acquiring
corporation" shall include stock of such corporation of any class which is not
preferred as to dividends or assets over any other class of stock of such
corporation and which is not subject to redemption and shall also include any
evidences of indebtedness, shares of stock or other securities which are
convertible into or exchangeable for any such stock, either immediately or upon
the arrival of a specified date or the happening of a specified event and any
warrants or other rights to subscribe for or purchase any such stock. The
foregoing provisions of this Section 11 shall similarly apply to successive
reorganizations, reclassifications, mergers, consolidations or disposition of
assets.

     12. Voluntary Adjustment by the Company. The Company may at any time during
the term of this Warrant, reduce the then current Exercise Price to any amount
and for any period of time deemed appropriate by the Board of Directors of the
Company.


                                      E-46



<PAGE>   6

     13. Notice of Adjustment. Whenever the number of Warrant Shares or number
or kind of securities or other property purchasable upon the exercise of this
Warrant or the Exercise Price is adjusted, as herein provided, the Company shall
promptly mail by registered or certified mail, return receipt requested, to the
holder of this Warrant notice of such adjustment or adjustments setting forth
the number of Warrant Shares (and other securities or property) purchasable upon
the exercise of this Warrant and the Exercise Price of such Warrant Shares (and
other securities or property) after such adjustment, setting forth a brief
statement of the facts requiring such adjustment and setting forth the
computation by which such adjustment was made. Such notice, in the absence of
manifest error, shall be conclusive evidence of the correctness of such
adjustment.

     14. Notice of Corporate Action. If at any time:

          (a) the Company shall take a record of the holders of its Common Stock
for the purpose of entitling them to receive a dividend or other distribution,
or any right to subscribe for or purchase any evidences of its indebtedness, any
shares of stock of any class or any other securities or property, or to receive
any other right, or

          (b) there shall be any capital reorganization of the Company, any
reclassification or recapitalization of the capital stock of the Company or any
consolidation or merger of the Company with, or any sale, transfer or other
disposition of all or substantially all the property, assets or business of the
Company to, another corporation or,

          (c) there shall be a voluntary or involuntary dissolution, liquidation
or winding up of the Company;

then, in any one or more of such cases, the Company shall give to Holder (i) at
least 30 days' prior written notice of the date on which a record date shall be
selected for such dividend, distribution or right or for determining rights to
vote in respect of any such reorganization, reclassification, merger,
consolidation, sale, transfer, disposition, liquidation or winding up, and (ii)
in the case of any such reorganization, reclassification, merger, consolidation,
sale, transfer, disposition, dissolution, liquidation or winding up, at least 30
days' prior written notice of the date when the same shall take place. Such
notice in accordance with the foregoing clause also shall specify (i) the date
on which any such record is to be taken for the purpose of such dividend,
distribution or right, the date on which the holders of Common Stock shall be
entitled to any such dividend, distribution or right, and the amount and
character thereof, and (ii) the date on which any such reorganization,
reclassification, merger, consolidation, sale, transfer, disposition,
dissolution, liquidation or winding up is to take place and the time, if any
such time is to be fixed, as of which the holders of Common Stock shall be
entitled to exchange their shares of Common Stock for securities or other
property deliverable upon such disposition, dissolution, liquidation or winding
up. Each such written notice shall be sufficiently given if addressed to Holder
at the last address of Holder appearing on the books of the Company and
delivered in accordance with Section 16(d).


                                      E-47



<PAGE>   7

     15. Authorized Shares. The Company covenants that during the period the
Warrant is outstanding, it will reserve from its authorized and unissued Common
Stock a sufficient number of shares to provide for the issuance of the Warrant
Shares upon the exercise of any purchase rights under this Warrant. The Company
further covenants that its issuance of this Warrant shall constitute full
authority to its officers who are charged with the duty of executing stock
certificates to execute and issue the necessary certificates for the Warrant
Shares upon the exercise of the purchase rights under this Warrant. The Company
will take all such reasonable action as may be necessary to assure that such
Warrant Shares may be issued as provided herein without violation of any
applicable law or regulation, or of any requirements of the Principal Market
upon which the Common Stock may be listed.

     The Company shall not by any action, including, without limitation,
amending its certificate of incorporation or through any reorganization,
transfer of assets, consolidation, merger, dissolution, issue or sale of
securities or any other voluntary action, avoid or seek to avoid the observance
or performance of any of the terms of this Warrant, but will at all times in
good faith assist in the carrying out of all such terms and in the taking of all
such actions as may be necessary or appropriate to protect the rights of Holder
against impairment. Without limiting the generality of the foregoing, the
Company will (a) not increase the par value of any shares of Common Stock
receivable upon the exercise of this Warrant above the amount payable therefor
upon such exercise immediately prior to such increase in par value, (b) take all
such action as may be necessary or appropriate in order that the Company may
validly and legally issue fully paid and nonassessable shares of Common Stock
upon the exercise of this Warrant, and (c) use its best efforts to obtain all
such authorizations, exemptions or consents from any public regulatory body
having jurisdiction thereof as may be necessary to enable the Company to perform
its obligations under this Warrant.

     Before taking any action which would result in an adjustment in the number
of shares of Common Stock for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions
thereof, or consents thereto, as may be necessary from any public regulatory
body or bodies having jurisdiction thereof.

     16. Miscellaneous.

          (a) Jurisdiction. This Warrant shall be binding upon any successors or
assigns of the Company. This Warrant shall constitute a contract under the laws
of New York, without regard to its conflict of law, principles or rules, and be
subject to arbitration pursuant to the terms set forth in the Purchase
Agreement.

          (b) Restrictions. The holder hereof acknowledges that the Warrant
Shares acquired upon the exercise of this Warrant, if not registered, will have
restrictions upon resale imposed by state and federal securities laws.

          (c) Nonwaiver and Expenses. No course of dealing or any delay or
failure to exercise any right hereunder on the part of Holder shall operate as a
waiver of such right or otherwise prejudice Holder's rights, powers or remedies,
notwithstanding all rights hereunder terminate on the Termination Date. If the
Company fails to comply with any provision of this Warrant, the Company shall
pay to Holder such amounts as shall be sufficient to cover any costs and
expenses including, but not limited to, reasonable attorneys' fees, including
those of appellate proceedings, incurred by Holder in collecting any amounts due
pursuant hereto or in otherwise enforcing any of its rights, powers or remedies
hereunder.


                                      E-48



<PAGE>   8

          (d) Notices. Any notice, request or other document required or
permitted to be given or delivered to the holder hereof by the Company shall be
delivered in accordance with the notice provisions of the Purchase Agreement.

          (e) Limitation of Liability. No provision hereof, in the absence of
affirmative action by Holder to purchase shares of Common Stock, and no
enumeration herein of the rights or privileges of Holder hereof, shall give rise
to any liability of Holder for the purchase price of any Common Stock or as a
stockholder of the Company, whether such liability is asserted by the Company or
by creditors of the Company.

          (f) Remedies. Holder, in addition to being entitled to exercise all
rights granted by law, including recovery of damages, will be entitled to
specific performance of its rights under this Warrant. The Company agrees that
monetary damages would not be adequate compensation for any loss incurred by
reason of a breach by it of the provisions of this Warrant and hereby agrees to
waive the defense in any action for specific performance that a remedy at law
would be adequate.

          (g) Successors and Assigns. Subject to applicable securities laws,
this Warrant and the rights and obligations evidenced hereby shall inure to the
benefit of and be binding upon the successors of the Company and the successors
and permitted assigns of Holder. The provisions of this Warrant are intended to
be for the benefit of all Holders from time to time of this Warrant and shall be
enforceable by any such Holder or holder of Warrant Shares.

          (h) Indemnification. The Company agrees to indemnify and hold harmless
Holder from and against any liabilities, obligations, losses, damages,
penalties, actions, judgments, suits, claims, costs, attorneys' fees, expenses
and disbursements of any kind which may be imposed upon, incurred by or asserted
against Holder in any manner relating to or arising out of any failure by the
Company to perform or observe in any material respect any of its covenants,
agreements, undertakings or obligations set forth in this Warrant; provided,
however, that the Company will not be liable hereunder to the extent that any
liabilities, obligations, losses, damages, penalties, actions, judgments, suits,
claims, costs, attorneys' fees, expenses or disbursements are found in a final
non-appealable judgment by a court to have resulted from Holder's negligence,
bad faith or willful misconduct in its capacity as a stockholder or
warrantholder of the Company.

          (i) Amendment. This Warrant may be modified or amended or the
provisions hereof waived with the written consent of the Company and the Holder.


                                      E-49



<PAGE>   9

          (j) Severability. Wherever possible, each provision of this Warrant
shall be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Warrant shall be prohibited by or
invalid under applicable law, such provision shall be ineffective to the extent
of such prohibition or invalidity, without invalidating the remainder of such
provisions or the remaining provisions of this Warrant.

          (k) Headings. The headings used in this Warrant are for the
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

          IN WITNESS WHEREOF, the Company has caused this Warrant to be executed
by its officer thereunto duly authorized.

Dated: November 4, 1999

       Nymox Pharmaceutical Corporation

       By: /s/     Paul Averback
          ------------------------------
           Dr. Paul Averback, President


                                      E-50



<PAGE>   10




NOTICE OF EXERCISE

To:      Nymox Pharmaceutical Corporation

(1) The undersigned hereby elects to purchase ________ shares of Common Stock
(the "Common Stock"), of Nymox Pharmaceutical Corporation pursuant to the terms
of the attached Warrant, and tenders herewith payment of the exercise price in
full, together with all applicable transfer taxes, if any.

(2) Please issue a certificate or certificates representing said shares of
Common Stock in the name of the undersigned or in such other name as is
specified below:


                           -------------------------------
                           (Name)


                           -------------------------------
                           (Address)


                           -------------------------------




Dated:

                                    ------------------------------
                                    Signature


                                      E-51



<PAGE>   11


ASSIGNMENT FORM

(To assign the foregoing warrant, execute this form and supply required
information. Do not use this form to exercise the warrant.)

FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are
hereby assigned to

______________________________________________ whose address is

_______________________________________________________________.


_______________________________________________________________


                                      Dated:  __________________, _______

                          Holder's Signature: ___________________________

                           Holder's Address:  ___________________________

                                              ___________________________




Signature Guaranteed:  ___________________________________________

NOTE: The signature to this Assignment Form must correspond with the name as it
appears on the face of the Warrant, without alteration or enlargement or any
change whatsoever, and must be guaranteed by a bank or trust company. Officers
of corporations and those acting in an fiduciary or other representative
capacity should file proper evidence of authority to assign the foregoing
Warrant.


                                      E-52

<PAGE>   1

EXHIBIT 3.0

<TABLE>
<S>                                                  <C>     <C>
Industry Canada                                                     Industrie Canada

CERTIFICATE OF AMENDMENT                                            CERTIFICAT DE MODIFICATION

CANADA BUSINESS                                                     LOI CANADIENNE SUR LES
CORPORATIONS ACT                                                    SOCIETES PAR ACTIONS

- -------------------------------------------------------------------------------------------------

NYMOX PHARMACEUTICAL CORPORATION/                                    315235-9
CORPORATION PHARMACEUTIQUE NYMOX

- --------------------------------------                       ------------------------------------

NAME OF CORPORATION / DENOMINATION DE LA SOCIETE              CORPORATION NUMBER / NUMERO DE LA SOCIETE


I hereby certify that the articles of the above-              Je certifie que les status de
la societe named corporation were amended                     susmentionee ont ete modifies:

(a) under section 13 of the Canada Business          ____     (a) en vertu de l'article 13 de la Loi Canadienne
Corporations Act in accordance with the attached              sur les societes par actions, conformement a
notice;                                                       l'avis ci-joint;

(b) under section 27 of the Canada Business          ____     (b) en vertu del'article 27 de la Loi Canadienne
Corporations Act as set out in the attached                   sur les societes par actions, tel qu'il est indique
articles of amendment designating a series                    dans les clauses modificatrices ci-jointes designant une
of shares;                                                    serie d'actions;

(c) under section 179 of the Canada Business           X      (c) en vertu de l'article 179 de la Loi Canadienne
Corporations Act as set out in the attached                    sur les societes par actions, tel qu'il est indique
articles of amendment;                                         dans les clauses modificatrices ci-jointes;

(d) under section 191 of the Canada Business         ____     (d) en vertu de l'article 191 de la Loi Canadienne
Corporations Act as set out in the attached                    sur les societes par actions, tel qu'il est indique
articles of reorganization.                                    dans les clauses de reorganisation ci-jointes.


                                                               SEPTEMBER 20, 1995 / LE 20 SEPTEMBRE 1995

Director - Directeur                                           Date of Amendment - Date de modification

- -------------------------------------------------------------------------------------------------
</TABLE>
                                     Canada
                             IC3411(10-94)(cca2140)


                                      E-53
<PAGE>   2

<TABLE>
<S>                     <C>
Consumer and Corporate  Consommation et Affaires
Affairs Canada          Commerciales Canada
</TABLE>

<TABLE>
<S>                     <C>                             <C>
FORM 4                  FORMULE 4
Canada Business         Loi regissant les societes      ARTICLES OF AMENDMENT/CLAUSES
MODIFICATRICES
Corporations Act        par actions de regime federal  (SECTION 27 OR 177) (ARTICLES 27 OU 177)
</TABLE>

<TABLE>
<S>                                                    <C>
- ----------------------------------------------------------------------------------------------------------
1 - Name of Corporation / Denomination de la societe   2 - Corporation No. / No de la societe
               3152359 CANADA INC.                                      315235-9
- ----------------------------------------------------------------------------------------------------------
3 - The articles of the above-named corporation        Les statuts de la societe mentionnee ci-dessus sont
    are amended as follows:                            modifies de la facon suivante:
</TABLE>
         Section 1 of the articles of incorporation dated May 30, 1995 is hereby
         replaced with:

         NYMOX PHARMACEUTICAL CORPORATION /
         CORPORATION PHARMACEUTIQUE NYMOX

- -        Section 3 of the articles of incorporation dated
         May 30, 1995 is hereby replaced with:

         An unlimited number of Common shares.

- -        Section 4 of the articles of incorporation dated
         May 30, 1995 is hereby replaced with:

         N/A

- -        Section 5 of the articles of incorporation dated
         May 30, 1995 is hereby replaced with:

         Minimum:   5               Maximum:   15


- -        Section 7 of the articles of incorporation dated
         May 30, 1995 is hereby replaced with:

         The attached Schedule I.
<TABLE>
<S>                          <C>                              <C>
- ----------------------------------------------------------------------------------------------------------------------
Date                         Signature                        Title / Titre

September 19, 1995                                            Director
- -----------------------------------------------------------------------------------------------------------------------
                             Pierre Barnard                   FOR DEPARTMENTAL USE ONLY / A LUSAGE DU MINISTERE SEULEMENT
                                                              Filed / Deposee
                                                              SEPTEMBER 25, 1995
- -----------------------------------------------------------------------------------------------------------------------
</TABLE>
7530-21-936-1387 (01-93)46


                                      E-54
<PAGE>   3


Industry Canada

<TABLE>
<S>                                                           <C>
CERTIFICATE OF INCORPORATION                                  CERTIFICAT DE CONSTITUTION

Canada Business                                               Loi canadienne sur les societes
Corporations Act                                              par actions

3152359 CANADA INC.                                           315235-9

- -----------------------------------------------------------------------------------------------------------------------
Name of corporation-Denomination de la societe                Corporation number-Numero de la societe

I hereby certify that the above-named                         Je certifie que la societe
corporation, the articles of                                  susmentionnee, don't les statuts
incorporation of which are attached,                          constitutifs sont joints, a ete
was incorporated under the                                    constituee en societe en vertu de la

Canada Business Corporations Act.                             Loi canadienne sur les societes par actions.


                                                              MAY 30, 1995 / LE 30 MAI 1995
DIRECTOR - DIRECTEUR                                          DATE OF INCORPORATION - DATE DE CONSTITUTION
</TABLE>

                                                                          CANADA


                                      E-55



<PAGE>   4




                 FORM 1 - ARTICLES OF INCORPORATION (SECTION 6)
                  FORMULE 1 - STATUTS CONSTITUTIFS (ARTICLE 6)

CANADA BUSINESS CORPORATIONS ACT
                         1.2.1.1
                        Loi regissant les societes par actions de regime federal

- --------------------------------------------------------------------------------
1 - Name of Corporation / Denomination de la societe

                              3152359 CANADA INC.
- --------------------------------------------------------------------------------
2 - The place in Canada where the registered office is to be situated
    Lieu au Canada ou doit etre situe le siege social

Metropolitan Region of Montreal, Province of Quebec
- --------------------------------------------------------------------------------
3 - The classes and any maximum number of shares that the corporation is
    authorized to issue / Categories et tout nombre maximal d'actions que la
    societe est autorisee a emettre

See schedule 1 annexed hereto and forming and integral part of these articles.
- --------------------------------------------------------------------------------
4 - Restrictions if any on share transfers / Restrictions sur le transfert des
    actions, s'il y a lieu

Subject to the provisions of any unanimous shareholders agreement, no transfer
of shares in the capital of the Corporation shall be valid unless approved by a
resolution of the directors adopted according to the Canada Business
Corporations Act and the Corporation's by-laws. However, the effective date of a
transfer of shares shall be the date on which such transfer occurred, even
though such approval may have been granted after the said transfer.
- --------------------------------------------------------------------------------
5 - Number (or minimum and maximum number) of directors
    Nombre (ou nombre minimum et maximum) d'administrateurs

                            Minimum: 1 -- Maximum: 9
- --------------------------------------------------------------------------------
6 - Restrictions if any on business the corporation may carry on
    Limites imposees quant aux activites commerciales que la societe peut
    exploiter, s'il y a lieu

                                      N/A
- --------------------------------------------------------------------------------
7 - Other provinces if any / Autres dispositions s'il y a lieu

 See schedule 2 annexed hereto and forming an integral part of these articles.
- --------------------------------------------------------------------------------
7 - Incorporators / Fondateurs
- --------------------------------------------------------------------------------
                           Address (include postal code)
Name / Nom                 Adresse (inclure la code postal)            Signature
- --------------------------------------------------------------------------------
GIROUX, Diane              1010 Sherbrooke Street West
                           Suite 1100
                           Montreal, Quebec, H3A 2R7
- --------------------------------------------------------------------------------

FOR DEPARTMENT USE ONLY / A L'USAGE DU                          FILED / DEPOSEEE
MINISTERE SEULEMENT
Corporation No. / No. de la societe   315235-9                     JUNE 01, 1995

- --------------------------------------------------------------------------------


                                      E-56
<PAGE>   5


                                   SCHEDULE 1

THE CORPORATION IS AUTHORIZED TO ISSUE AN UNLIMITED NUMBER OF CLASS "A", CLASS
"B", CLASS "C", CLASS "D", CLASS "E" AND CLASS "F" SHARES. THE SAID SHARES SHALL
HAVE THE FOLLOWING RIGHTS, PRIVILEGES, RESTRICTIONS AND CONDITIONS.

1.       VOTING RIGHTS

         1.1      The holders of the Class "A", Class "B", Class "C" and Class
                  "E" shares shall be entitled to one (1) vote for each Class
                  "A", Class "B", Class "C" and Class "E" share held by them at
                  all meetings of shareholders.

         1.2      Except as hereinafter provided for, the holders of the Class
                  "D" and Class "F" shares shall not be entitled to vote for the
                  election of directors or for any other purpose nor shall they
                  be entitled to attend shareholders' meetings.

2.       LIQUIDATION, DISSOLUTION OR OTHER DISTRIBUTION OF ASSETS

         2.1      In the event of the voluntary or involuntary liquidation,
                  dissolution, winding-up or other distribution of assets of the
                  Corporation:

                  2.1.1    the holders of the Class "A" shares shall be entitled
                           to receive the remaining property of the Corporation
                           to the exclusion of the holders of shares of any
                           other class;

                  2.1.2    the holders of the Class "E" shares shall be entitled
                           to receive for each Class "E" share, pro rata, before
                           any distribution of any part of the assets of the
                           Corporation among the holders of shares of any other
                           class, an amount equal to its Redemption Value and
                           any dividends declared thereon and unpaid and nothing
                           more;

                  2.1.3    the holders of the Class "D" shares shall be entitled
                           to receive for each Class "D" share, pro rata, before
                           any distribution of any part of the assets of the
                           Corporation among the holders of shares of any other
                           class, except Class "E" shares, an amount equal to
                           its Redemption Value and any dividends declared
                           thereon and unpaid and nothing more;

                  2.1.4    the holders of the Class "F" shares shall be entitled
                           to receive for each Class "F" share, pro rata, before
                           any distribution of any part of the assets of the
                           Corporation among the holders of Class "A", Class "B"
                           and Class "C" shares an amount equal to its
                           Redemption Value and any dividends declared thereon
                           and unpaid and nothing more;

                  2.1.5    the holders of the Class "C" shares shall be entitled
                           to receive for each Class "C" share, pro rata, before
                           any distribution of any part of the assets of the
                           Corporation among the holders of Class "A" and Class
                           "B" shares an amount equal to its Redemption Value
                           and any dividends declared thereon and unpaid and
                           nothing more;


                                      E-57



<PAGE>   6

                  2.1.6    the holders of the Class "B" shares shall be entitled
                           to receive for each Class "B" share, pro rata, before
                           any distribution of any part of the assets of the
                           Corporation among the holders of Class "A" shares, an
                           amount equal to one hundred percent (100%) of the
                           amount paid up thereon and nothing more.

3.       DECLARATION OF DIVIDENDS AND RANKING AS TO DIVIDENDS

         3.1      The holders of the Class "B" shares shall not be entitled to
                  any dividend.

         3.2      The holders of the Class "A" shares shall be entitled, subject
                  to the following provisions, to receive such dividends as are
                  declared by the directors of the Corporation.

         3.3      The holders of the Class "E" shares shall, in each fiscal year
                  of the Corporation, in the discretion of the director or
                  directors, but always in preference and priority to any
                  payment of dividends on shares of any other class for such
                  year, be entitled, out of any or all profits or surplus
                  available for dividends, to non-cumulative dividends at the
                  rate of ten percent (10%) per annum on the Redemption Value of
                  the Class "E" shares held by them. If in any such year, after
                  providing for the dividend on the Class "E" shares, there
                  shall remain any profits or surplus available for dividends,
                  such profits or surplus or any part thereof may, in the
                  discretion of the director or directors, be applied to the
                  dividends on shares of other classes. The holders of the Class
                  "E" shares shall not be entitled to any dividend in excess of
                  the non-cumulative dividends at the rate hereinabove provided
                  for.

         3.4      The holders of the Class "D" shares shall, in each fiscal year
                  of the Corporation, in the discretion of the director or
                  directors, but always in preference and priority to any
                  payment of dividends on shares of any other class except Class
                  "E" shares for such year, be entitled, out of any or all
                  profits or surplus available for dividends, to noncumulative
                  dividends at the rate of ten percent (10%) per annum on the
                  Redemption Value of the Class "D" shares held by them. If in
                  any such year, after providing for the dividend on the Class
                  "D" shares, there shall remain any profits or surplus
                  available for dividends, such profits or surplus or any part
                  thereof may, in the discretion of the director or directors,
                  be applied to the dividends on shares of other classes. The
                  holders of the Class "D" shares shall not be entitled to any
                  dividend in excess of the non-cumulative dividends at the rate
                  hereinabove provided for.

         3.5      The holders of the Class "F" shares shall, in each fiscal year
                  of the Corporation, in the discretion of the director or
                  directors, but always in preference and priority to any
                  payment of dividends on Class "A" and Class "C" shares for
                  such year, be entitled, out of any or all profits or surplus
                  available for dividends, to non-cumulative dividends at the
                  rate of ten percent (10%) per annum on the Redemption Value of
                  the Class "F" shares held by them. If in any such year, after
                  providing for the dividend on the Class "F" shares, there
                  shall remain any profits or surplus available for dividends,
                  such profits or surplus or any part thereof may, in the
                  discretion of the director or directors, be applied to the
                  dividends on shares of other classes. The holders of the Class
                  "F" shares shall not be entitled to any dividend in excess of
                  the non-cumulative dividends at the rate hereinabove provided
                  for.


                                      E-58



<PAGE>   7

         3.6      The holders of the Class "C" shares shall, in each fiscal year
                  of the Corporation, in the discretion of the director or
                  directors, but always in preference and priority to any
                  payment of dividends on Class "A" shares for such year, be
                  entitled, out of any or all profits or surplus available for
                  dividends, to non-cumulative dividends at the rate of ten
                  percent (10%) per annum on the Redemption Value of the Class
                  "C" shares held by them. If in any such year, after providing
                  for the dividend on the Class "C" shares, there shall remain
                  any profits or surplus available for dividends, such profits
                  or surplus or any part thereof may, in the discretion of the
                  director or directors, be applied to the dividends on shares
                  of other classes. The holders of the Class "C" shares shall
                  not be entitled to any dividend in excess of the
                  non-cumulative dividends at the rate hereinabove provided for.

         3.7      Notwithstanding the foregoing, the Corporation shall not be
                  entitled to declare any dividend on shares of any class unless
                  it shall have, after the payment of such dividend, sufficient
                  assets to be legally entitled to acquire all of its Class "D"
                  and Class "E" shares pursuant to section 5 hereof.

4.       REDEMPTION OF SHARES AT THE OPTION OF THE CORPORATION

         4.1      Subject to the provisions of the Canada Business Corporations
                  Act (the "Act"), the Corporation may redeem, upon giving
                  notice as hereinafter provided, the whole or any part of the
                  Class "C", Class "D", Class "E" and Class "F" shares without
                  preference or distinction, on payment for each share to be
                  redeemed of an amount equal to its Redemption Value together
                  with all dividends declared thereon and unpaid. If only part
                  of the then outstanding Class "C", Class "D", Class "E" and
                  Class "F" shares are, at any time, to be redeemed, the shares
                  so to be redeemed shall be selected in such manner as the
                  director or directors in their discretion shall decide and the
                  director or directors may choose to redeem shares of one class
                  only or of several classes or, if the director or directors so
                  determine, the shares to be redeemed may be redeemed pro rata,
                  disregarding fractions, and the director or directors may make
                  such adjustments as may be necessary to avoid the redemption
                  of fractions of shares. Not less than thirty (30) days' notice
                  in writing of such redemption shall be given by mailing such
                  notice to the registered holders of the shares to be redeemed,
                  specifying the date and place or places of redemption. If
                  notice of any such redemption be given by the Corporation in
                  the manner aforesaid and an amount sufficient to redeem the
                  shares be deposited with any trust company of chartered bank
                  in Canada as specified in the notice on or before the date
                  fixed for redemption, dividends on the shares to be redeemed
                  shall cease after the date so fixed for redemption and the
                  holders thereof shall thereafter have no rights against the
                  Corporation in respect thereof except, upon the surrender of
                  certificates for such shares, to receive payment thereof out
                  of the money so deposited. After the redemption price of such
                  shares has been deposited with any trust company or chartered
                  bank in Canada as aforesaid, notice shall be given to the
                  holders of any share called for redemption who have failed to
                  present certificates representing shares to be redeemed within
                  two (2) months of the date specified for redemption that the
                  money has been so deposited and may be obtained by the holders
                  of the said shares upon presentation of the certificates
                  representing such shares called for redemption at the said
                  trust company or chartered bank. Notwithstanding the
                  foregoing, the Corporation shall not be entitled to redeem
                  shares of any class unless it shall have, after such
                  redemption, sufficient assets to be legally entitled to
                  acquire all of its Class "D" and Class "E" shares pursuant to
                  section 5 hereof.


                                      E-59



<PAGE>   8

5.       REDEMPTION OF SHARES AT THE OPTION OF THE HOLDER

         5.1      The holders of the Class "D" and Class "E" shares shall be
                  entitled to require the Corporation to redeem, at any time and
                  from time to time after the date of issue of any Class "D" or
                  Class "E" share upon giving notice as hereinafter provided,
                  all or any number of Class "D" and Class "E" shares registered
                  in the name of such holders in the books of the Corporation
                  for a price equal to their Redemption Value together with all
                  dividends declared thereon and unpaid.

         5.2      The holder of the Class "D" and Class "E" shares exercising
                  his option to have the Corporation redeem his shares, shall
                  give notice to the Corporation, which notice shall set out the
                  date on which the Corporation is to redeem the said shares,
                  which date shall not be earlier than ten (10) days nor later
                  than thirty (30) days from the date of the notice and if the
                  holder desires to have less than all of the Class "D" and
                  Class "E" shares registered in his name redeemed by the
                  Corporation, the number of the holder's shares to be redeemed.
                  The date on which the redemption, at the option of the holder,
                  is to occur is hereinafter referred to as the "Optional
                  Redemption Date".

         5.3      Upon delivery to the Corporation of a share certificate or of
                  share certificates representing the Class "D" and Class "E"
                  shares which the holder desires to have the Corporation
                  redeem, the Corporation shall, on the Optional Redemption
                  Date, to the extent permitted by the applicable law, redeem
                  such shares by paying to the registered holder thereof the
                  redemption price therefor.

         5.4      Upon payment of the redemption price of the Class "D" and
                  Class "E" shares so redeemed by the Corporation, the holders
                  thereof shall cease to be entitled to dividends or to exercise
                  any rights of the holders in respect thereof.

         5.5      Should the redemption by the Corporation on any Optional
                  Redemption Date of any Class "D" and Class "E" shares to be
                  redeemed on such date be contrary to applicable law, the
                  Corporation shall not redeem more than the maximum number of
                  Class "D" and Class "E" shares, rounded to the next lower
                  multiple of one, which the Corporation determines it is then
                  permitted to redeem, such redemptions to be made, disregarding
                  fractions of shares and in proportion to the Redemption Value
                  of the Class "D" and Class "E" shares required to be redeemed,
                  and the Corporation shall issue new certificates representing
                  the Class "D" and Class "E" shares not redeemed by the
                  Corporation and the Corporation shall redeem in the manner
                  contemplated by paragraph 4.1 hereof on each redemption date
                  thereafter the maximum number of such Class "D" and Class "E"
                  shares as would then not be contrary to applicable law.

6.       PURCHASE OF SHARES

         6.1      The Corporation shall have the right, at its option at any
                  time and from time to time, subject to the provisions of the
                  Act, to purchase for cancellation out of surplus or subject to
                  the Act to purchase otherwise, the whole or any part of the
                  Class "C", Class "D", Class "E" and Class "F" shares then
                  outstanding pursuant to tenders received by the Corporation
                  upon request for tenders addressed to all holders of Class
                  "C", Class "D", Class "E" and Class "F" shares at the lowest
                  price at which, in the opinion of the director or directors,
                  such shares are obtainable but not exceeding their Redemption
                  Value together with all dividends declared thereon and unpaid.
                  If, in response to an invitation for tenders, two (2) or more
                  shareholders submit tenders for shares of the same class at
                  the same price and if such tenders are accepted by the
                  Corporation in whole or in part, then, unless the Corporation
                  accepts all such tenders in whole, the Corporation shall
                  accept such tenders in proportion as near as may be to the
                  number of shares of the same class offered in each such
                  tender. The director or directors may choose to purchase for
                  cancellation or purchase otherwise shares of one class only or
                  of several classes. Notwithstanding the foregoing, the
                  Corporation shall not be entitled to purchase for cancellation
                  or purchase otherwise shares of any class, unless it shall
                  have, after such purchase, sufficient assets to be legally
                  entitled to acquire all of its Class "D" and Class "E" shares
                  pursuant to section 5 hereof.


                                      E-60


<PAGE>   9
7.       REDEMPTION VALUE

         7.1      For purposes of application of the provisions hereof, the
                  Redemption Value of each Class "C", Class "D", Class "E" and
                  Class "F" share shall be equal to:

                  7.1.1    in the case of a share issued for a consideration in
                           money, the amount of the consideration for which it
                           was issued;



                  7.1.2    in the case of a share issued for a consideration
                           other than money, the fair market value of the
                           consideration for which the share was issued.  The
                           fair market value of the consideration for which the
                           share was issued shall be determined by the director
                           or directors of the Corporation by resolution upon
                           the issuance of the share ("Determined Redemption
                           Value").  The said determination shall be final and
                           binding provided that, if at any time the Minister of
                           National Revenue or the Minister of Revenue of any
                           province of Canada makes or proposes to make any tax
                           assessment or reassessment based on the assumption
                           that the fair market value of the consideration for
                           which the share was issued was higher or lower than
                           the Determined Redemption Value, then the Redemption
                           Value of such share shall be increased or decreased
                           so that it shall be equal to the amount finally
                           determined to be the fair market value of the
                           consideration for which the share was issued.  Any
                           such determination shall be deemed to be a final
                           determination if it is made pursuant to an assessment
                           or reassessment by the Minister of National Revenue
                           or the Minister of Revenue of any province of Canada
                           and no appeal is taken therefrom or if any agreement
                           is reached between any holder of the share and any
                           such taxing authority in settlement of a dispute
                           regarding such determination or if determined by a
                           court or tribunal of competent jurisdiction and no
                           appeal is taken therefrom.

         7.2      Should a redemption, either pursuant to section 4 or to
                  section 5 hereof, of Class "C", Class "D", Class "E" or Class
                  "F" shares have occurred or should the Corporation have paid
                  dividends calculated on the Determined Redemption Value of the
                  Class "C", Class "D", Class "E" or Class "F" shares before an
                  increase or decrease in the Redemption Value of the Class "C",
                  Class "D", Class "E" or Class "F" shares resulting from the
                  application of paragraph 7.1.2 hereof, then:

                  7.2.1    in case of an increase in the Redemption Value of
                           shares of any such class, the Corporation shall pay
                           to any person whose shares were redeemed at the
                           Determined Redemption Value for shares of such class
                           an amount equal to the difference between the
                           increased Redemption Value for shares of such class
                           and the Determined Redemption Value for shares of
                           such class and shall pay to any person who received
                           dividends based on the Determined Redemption Value
                           for shares of such class the difference between such
                           dividends and dividends as calculated on the
                           increased Redemption Value for shares of such class,
                           which amount shall bear interest at the annual prime
                           rate of the Royal Bank of Canada, running from the
                           date of the redemption or the date of the payment of
                           the dividend, whichever may be the case;


                                      E-61


<PAGE>   10
                  7.2.2    in case of a decrease in the Redemption Value for
                           shares of such class, the person whose shares were
                           redeemed either pursuant to section 4 or to section 5
                           hereof at the Determined Redemption Value for shares
                           of such class or who received dividends calculated on
                           the Determined Redemption Value for shares of such
                           class shall reimburse to the Corporation an amount
                           equal to the difference between the Determined
                           Redemption Value for shares of such class and the
                           decreased Redemption Value for shares of such class
                           in the case of a redemption and the difference
                           between the dividend calculated on the Determined
                           Redemption Value for shares of such class and the
                           dividend calculated on the decreased Redemption Value
                           for shares of such class in the case of the payment
                           of a dividend, which amount shall bear interest at
                           the annual prime rate of the Royal Bank of Canada,
                           running from the date of the redemption or the date
                           of the payment of the dividend, whichever may be the
                           case.



8.       AMENDMENTS SUBJECT TO CONFIRMATION BY ARTICLES OF AMENDMENT

         8.1      Subject to confirmation by articles of amendment and the issue
                  of a Certificate of Amendment, the director or directors of
                  the Corporation may, at any time or times or from time to
                  time, adopt a resolution or resolutions whereby the terms
                  hereof and of the foregoing paragraphs may be altered, amended
                  or repealed or the application thereof suspended in any
                  particular case and changes made in the rights, privileges,
                  restrictions and conditions attached to the shares of the
                  Corporation, but no such resolution shall have any force or
                  effect until after it has been sanctioned by the vote of the
                  holders of at least seventy-five percent (75%) in value of the
                  voting shares then outstanding and of at least seventy-five
                  percent (75 %) in value of shares of each class affected by
                  such amendment, in each case voting separately as a class at a
                  meeting or meetings specially called for such purpose.

                                   SCHEDULE 2

CLOSED COMPANY

1.       The Corporation will be a "closed company" as defined in the Securities
         Act (Quebec) and accordingly:

         1.1      the free transfer of shares of its capital stock will be
                  restricted according to its articles;

         1.2      the distribution to the public of securities issued by the
                  Corporation will be prohibited; and

         1.3      the number of its shareholders, exclusive of present or former
                  employees of the Corporation or of a subsidiary, will be
                  limited to fifty (50).


                                      E-62



<PAGE>   11

APPOINTMENT OF DIRECTORS

2.       The directors shall have the right to appoint one or more additional
         directors, who shall hold office for a term expiring not later than the
         close of the next annual meeting of shareholders, but the total number
         of directors so appointed may not exceed one third of the number of
         directors elected at the previous annual meeting of shareholders, the
         whole in accordance with section 106(8) of the Canada Business
         Corporations Act.


                                      E-63




<PAGE>   1

EXHIBIT 3.1

                        NYMOX PHARMACEUTICAL CORPORATION

                                LIST OF BY-LAWS

No. 1   Relating generally to the conduct of the affairs of the Corporation.

                                                                    May 30, 1995

                                  BY LAW NO. I

       A by-law relating generally to the transaction of the business and
                                   affairs of

                        NYMOX PHARMACEUTICAL CORPORATION

                                    CONTENTS

SECTION I         ---     INTERPRETATION
SECTION II        ---     BUSINESS OF THE CORPORATION
SECTION III       ---     BORROWING AND SECURITIES
SECTION IV        ---     DIRECTORS
SECTION V         ---     COMMITTEES
SECTION VI        ---     OFFICERS
SECTION VII       ---     PROTECTION OF DIRECTORS, OFFICERS AND OTHERS

SECTION VIII      ---     SHARES
SECTION IX        ---     MEETINGS OF SHAREHOLDERS
SECTION X         ---     NOTICES
SECTION XI        ---     EFFECTIVE DATE

            BE IT ENACTED as a by-law of the Corporation as follows:

                                   SECTION I

                                 INTERPRETATION

     1.1    DEFINITIONS - In the by-laws of the Corporation, unless the context
            otherwise requires:

            "Act" means the Canada Business Corporations Act and any statute
            that may be substituted therefor, as from time to time amended;

            "Appoint" includes "elect" and vice versa;

            "Articles" means the articles attached to the certificate of
            incorporation dated May 30, 1995 of the Corporation as from time to
            time amended or restated;

            "Board" means the board of directors of the Corporation;

            "By-laws" means this by-law and all other by-laws of the Corporation
            from time to time in force and effect;


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<PAGE>   2

         "Meeting of shareholders" means an annual meeting of shareholders and a
         special meeting of shareholders; "special meeting of shareholders"
         means a special meeting of all shareholders entitled to vote at an
         annual meeting of shareholders;

         "Non-business day" means Saturday, Sunday and any other day that is a
         holiday as defined in the Interpretation Act (Canada);

         "Recorded address" means in the case of a shareholder his address as
         recorded in the securities register; and in the case of joint
         shareholders the address appearing in the securities register in
         respect of such joint holding or the first address so appearing if
         there are more than one; and in the case of a director, officer,
         auditor or member of a committee of the board, his latest address as
         recorded in the records of the Corporation; "address" includes in all
         cases a telex number;

         "Signing officer" means, in relation to any instrument, any person
         authorized to sign the same on behalf of the Corporation by subsection
         2.4 or by a resolution passed pursuant thereto;

         "Unanimous shareholder agreement" means a written agreement among all
         the shareholders of the Corporation; or among all such shareholders and
         a person who is not a shareholder, that restricts in whole or in part,
         the powers of the directors to manage the business and affairs of the
         Corporation, as from time to time amended.

         Save as aforesaid, words and expressions defined in the Act have the
same meanings when used herein; and words importing the singular number include
the plural and vice versa; words importing gender include the masculine,
feminine and neuter genders; and words importing persons include individuals,
bodies corporate, partnerships, trusts and unincorporated organizations.

                                   SECTION II

                          BUSINESS OF THE CORPORATION

2.1 REGISTERED OFFICE - Until changed in accordance with the Act, the registered
office of the Corporation shall be located in the limits of the judicial
district stipulated in the articles and at such address in the same district as
the board may choose from time to time.

2.2 CORPORATE SEAL - Unless the Corporation adopts one by resolution of the
board, the Corporation shall have no corporate seal.

2.3 FINANCIAL YEAR - Until changed by the boars, the financial year of the
Corporation shall end on the last day of July in each year.

2.4 EXECUTION OF INSTRUMENTS - Deeds, transfers, assignments, contracts,
obligations, certificates and other instruments may be signed on behalf of the
Corporation by the chairman of the board president, managing director, director,
secretary or as the directors may otherwise authorize, from time to time, by
resolution. Any such authorization may be general or confined to specific
instances. In addition, the board may from time to time direct the manner in
which the person or persons by whom any particular instrument or class of
instruments may or shall be signed. Any signing officer may affix the corporate
seal to any instrument requiring the same.


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<PAGE>   3

2.5 DECLARATIONS - The president, any vice-president, treasurer, secretary,
secretary-treasurer general manager, chairman of the board, managing-director,
or any other officer or person nominated for the purpose by the president or any
vice-president are, and any one of them is authorized and empowered to appear
and make answer for, on behalf and in the name of the Corporation to all writs,
orders and interrogatories upon articulated facts issued out of any court and to
declare for, on behalf and in the name of the Corporation any answer to writs of
attachment by way of garnishment in which the Corporation is garnishee and to
make all affidavits and sworn declarations in connection therewith or in
connection with any and all judicial proceedings to which the Corporation is a
party and to make demands of abandonment or petitions for winding-up or
bankruptcy orders upon any debtor of the Corporation and to attend and vote at
all meetings of creditors of the Corporation's debtors and grant proxies in
connection therewith, and may generally do all such things in respect thereof as
they deem to be in the best interests of the Corporation.

2.6 BANKING ARRANGEMENTS - The banking business of the Corporation including,
without limitation, the borrowing of money and the giving of security therefor,
shall be transacted with such banks, trust companies or other bodies corporate
or organizations as may from time to time be designated by or under the
authority of the board. Such banking business or any part thereof shall be
transacted under such agreements, instructions and delegations of power as the
board may from time to time prescribe or authorize.

2.7 VOTING RIGHTS IN OTHER BODIES CORPORATE - The signing officers of the
Corporation may execute and deliver proxies and arrange for the issuance of
voting certificates or other evidence of the right to exercise the voting rights
attaching to any securities held by the Corporation. Such instruments,
certificates or other evidence shall be in favour of such person or persons as
may be determined by the officers executing such proxies or arranging for the
issuance of voting certificates or such other evidence of the right to exercise
such voting rights. In addition, the board may from time to time, direct the
manner in which and the person or persons by whom any particular voting rights
or class of voting rights may or shall be exercised.

                                   SECTION III

                            BORROWING AND SECURITIES

3.1 BORROWING POWER - The Board of Directors has the borrowing powers provided
by the Law.


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<PAGE>   4

                                   SECTION IV

                                    DIRECTORS

4.1 NUMBER OF DIRECTORS AND QUORUM - Until changed in accordance with the Act,
the board shall consist of not fewer than five (5) and not more than fifteen
(15) directors. The directors may from time to time, fix by resolution the
quorum for meetings of the board of directors and, until otherwise decided by
resolution of the board, and under reserve of any unanimous shareholders
agreement, a quorum for all meetings of the board shall consist of a majority of
the number of directors then in office.

4.2 QUALIFICATION - No person shall be qualified for election as a director if
he is less than eighteen (18) years of age; if he is of unsound mind and has
been so found by a court in Canada or elsewhere; if he is not an individual; or
if he has the status of a bankrupt. A director need not be a shareholder. A
majority of the directors shall be resident Canadians.

4.3 ELECTION, NUMBER AND TERM - The election of directors shall take place at
the first meeting of shareholders and at each annual meeting of shareholders and
all the directors then in office shall retire but, if qualified, shall be
eligible for re-election. The number of directors to be elected at any such
meeting shall be the number of directors then in office unless the directors or
the shareholders otherwise determine. The election shall be by resolution. If an
election of directors is not held at the proper time, the incumbent directors
shall continue in office until their successors are elected.

4.4 REMOVAL OF DIRECTORS - Subject to the provisions of the Act and to the
provisions of any unanimous shareholders agreement, the shareholders may by
ordinary resolution passed at a special meeting remove any director from office
and the vacancy created by such removal may be filled at the same meeting,
failing which it may be filled by the directors.

4.5 VACATION OF OFFICE - A director ceases to hold office when: he dies; he is
removed from office by the shareholders; he ceases to be qualified for election
as a director; or his written resignation is sent or delivered to the
Corporation, or if a time is specified in such resignation, at the time so
specified, whichever is later.

4.6 VACANCIES - Subject to the Act, a quorum of the board may fill a vacancy in
the board except a vacancy resulting from an increase in the minimum number of
directors or from a failure of the shareholders to elect the minimum number of
directors. In the absence of a quorum of the board, or if the vacancy has arisen
from a failure of the shareholders to elect the minimum number of directors, the
board shall forthwith call a special meeting of shareholders to fill the
vacancy. If the board fails to call such meeting or if there are no such
directors then in office, any shareholder may call the meeting.

4.7 ACTION BY THE BOARD - Subject to any unanimous shareholder agreement, the
board shall manage the business and affairs of the Corporation. Subject to
subsection 4.8, the powers of the board may be exercised by resolution passed at
a meeting at which a quorum is present or by resolution in writing signed by all
the directors entitled to vote on that resolution at a meeting of the board.
Where there is a vacancy in the board, the remaining directors may exercise all
the powers of the board so long as a quorum remains in office.


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<PAGE>   5
4.8 MEETINGS BY TELEPHONE - If all the directors consent, a director may
participate in a meeting of the board or of a committee of the board by means of
such telephone or other communication facilities as permit all persons
participating in the meeting to hear each other, and a director participating in
such a meeting by such means is deemed to be present at the meeting Any such
consent shall be effective whether given before or after the meeting to which it
relates and may be given with respect to all meetings of the board and of
committees of the board held while a director holds office.

4.9 PLACE OF MEETINGS - Meetings of the board may be held at any place in or
outside Canada unless the directors decide otherwise by unanimous resolution.

4.10 CALLING OF MEETINGS - Meetings of the board shall be held from time to time
and at such place as the board, the chairman of the board, the managing
director, the president or any two directors may determine.

4.11 NOTICE OF MEETING - Notice of the time and place of each meeting of the
board shall be given in the manner provided in subsection 10.1 to each director
not less than forty-eight (48) hours before the time when the meeting is to be
held. A notice of a meeting of directors need not specify the purpose of, or the
business to be transacted at the meeting except where the Act requires such
purpose or business to be specified, including any proposal to:

(a)      submit to the shareholders any question or matter requiring approval of
         the shareholders;

(b)      fill a vacancy among the directors or in the office of auditor;

(e)      issue securities;

(f)      declare dividends;

(g)      purchase, redeem or otherwise acquire shares of the Corporation;

(h)      pay a commission for the sale of shares;

(g)      approve a management proxy circular;

(h)      approve a take-over bid circular or directors' circular;

(i)      approve any annual financial statements; or

(j)      adopt, amend or repeal by-laws.

         A director may in any manner waive notice of or otherwise consent to a
meeting of the board and attendance of a director at a meeting of directors is a
waiver of notice of the meeting except where a director attends a meeting for
the express purpose of objecting to the transaction of any business on the
grounds that the meeting is not lawfully called.


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<PAGE>   6

4.12 FIRST MEETING OF NEW BOARD - Provided a quorum of directors is present,
each newly elected board may without notice hold its first meeting immediately
following the meeting of shareholders at which such board is elected.

4.13 ADJOURNED MEETING - Notice of an adjourned meeting of the board is not
required if the time and place of the adjourned meeting is announced at the
original meeting.

4.14 REGULAR MEETINGS - The board may appoint a day or days in any month or
months for regular meetings of the board at a place and hour to be named. A copy
of any resolution of the board fixing the place and time of such regular
meetings shall be sent to each director forthwith after being passed, but no
other notice shall be required for any such regular meeting except where the Act
requires the purpose thereof or the business to be transacted thereat to be
specified.

4.15 CHAIRMAN - The chairman of any meeting of the board shall be the first
mentioned of such of the following officers as have been appointed and who is a
director and is present at the meeting: chairman of the board, managing
director, president, or a vice-president who is a director. If no such officer
is present, the directors present shall choose one from amongst them to be
chairman.

4.16 VOTES TO GOVERN - At all meetings of the board every question shall be
decided by a majority of the votes cast on the question. In the event of a tie
the chairman of the meeting shall not be entitled to a second or casting vote.

4.17 CONFLICT OF INTEREST - A director or officer who is a party to, or who is a
director or officer of or has a material interest in any person who is a party
to, a material contract or proposed material contract with the Corporation,
shall disclose the nature and extent of his interest at the time and in the
manner provided by the Act.

4.18 REMUNERATION AND EXPENSES - Subject to any unanimous shareholder agreement,
the directors shall be paid such remuneration for their services as the board
may from time to time determine. The directors shall also be entitled to be
reimbursed for travelling and other expenses properly incurred by them in
attending meetings of the board or any committee thereof. Nothing herein
contained shall preclude any director from serving the Corporation in any other
capacity and receiving remuneration therefor.

4.19 ONLY ONE DIRECTOR - Where the Corporation has only one (1) director, that
director shall constitute the board and a meeting.

                                   SECTION V

                                   COMMITTEES

5.1 COMMITTEE OF DIRECTORS - The board may appoint a committee of directors,
however designated, and delegate to such committee any of the powers of the
board except those which, under the Act, a committee of directors has no
authority to exercise. A majority of the members of such committee shall be
resident Canadians.

5.2 TRANSACTION OF BUSINESS - Subject to the provisions of subsection 4.8, the
powers of a committee of directors may be exercised by a meeting at which a
quorum is present or by resolution in writing signed by all the members of such
committee who would have been entitled to vote on that resolution at a meeting
of the committee. Meetings of such committee may be held at any place in or
outside Canada.


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<PAGE>   7

                                   SECTION VI

                                    OFFICERS

6.1 APPOINTMENT - Subject to any unanimous shareholder agreement, the board may,
from time to time, appoint a president, one or more vice-presidents (to which
title may be added words indicating seniority or function), a secretary, a
treasurer and such other officers as the board may determine, including one or
more assistants to any of the officers so appointed. The board may specify the
duties of and, in accordance with this by-law and subject to the provisions of
the Act, delegate to such officers powers to manage the business and affairs of
the Corporation. Subject to subsections 6.2 and 6.3, an officer may but need not
be a director and one person may hold more than one office.

6.2 CHAIRMAN OF THE BOARD - The board may, from time to time, also appoint a
chairman of the board who shall be a director. If appointed, the board may
assign to him any of the powers and duties that are by any provisions of this
by-law assigned to the managing director or to the president; and he shall,
subject to the provisions of the Act, have such other powers and duties as the
board may specify. During the absence or disability of the chairman of the
board, his duties shall be performed and his powers exercised by the managing
director, if any, or by the president.

6.3 MANAGING DIRECTOR - The board may, from time to time, appoint a managing
director who shall be a resident Canadian and a director. If appointed, he shall
be the chief executive officer and, subject to the authority of the board, shall
have general supervision of the business and affairs of the Corporation; and he
shall, subject to the provisions of the Act, have such other powers and duties
as the board may specify. During the absence or disability of the president, or
if no president has been appointed, the managing director shall also have the
powers and duties of that office.

6.4 PRESIDENT - If appointed, the president shall be the chief operating officer
and, subject to the authority of the board, shall have general supervision of
the business of the Corporation; and he shall have such other powers and duties
as the board may specify. During the absence or disability of the managing
director, or if no managing director has been appointed, the president shall
also have the powers and duties of that office.

6.5 VICE-PRESIDENT - A vice-president shall have such powers and duties as the
board or the chief executive officer may specify.

6.6 SECRETARY - The secretary shall attend and be the secretary of all meetings
of the board shareholders and committees of the board and shall enter or cause
to be entered in records kept for that purpose minutes of all proceedings
thereat; he shall give or cause to be given, as and when instructed, all notices
to shareholders, directors, officers, auditors and members of committees of the
board; he shall be the custodian of the stamp or mechanical device generally
used for affixing the corporate seal of the Corporation and of all books,
papers, records, documents and instruments belonging to the Corporation, except
when some other officer or agent has been appointed for that purpose; and he
shall have such other powers and duties as the board or the chief executive
officer may specify.


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<PAGE>   8

6.7 TREASURER - The treasurer shall keep proper accounting records in compliance
with the Act and shall be responsible for the deposit of money, the safekeeping
of securities and the disbursement of the funds of the Corporation; he shall
render to the board whenever required an account of all his transactions as
treasurer and of the financial position of the Corporation; and he shall have
such other powers and duties as the board or the chief executive officer may
specify.

6.8 POWERS AND DUTIES OF OTHER OFFICERS - The powers and duties of all other
officers shall be such as the terms of their engagement call for or as the board
or the chief executive officer may specify. Any of the powers and duties of an
officer to whom an assistant has been appointed may be exercised and performed
by such assistant, unless the board or the chief executive officer otherwise
directs.

6.9 VARIATION OF POWERS AND DUTIES - The board may, from time to time and
subject to the provisions of the Act, vary, add to or limit the powers and
duties of any officer.

6.10 TERM OF OFFICE - The board, in its discretion, but subject to the
provisions of any unanimous shareholders agreement may remove any officer of the
Corporation, without prejudice to such officer's rights under any employment
contract. Otherwise each officer appointed by the board shall hold office until
his successor is appointed.

6.11 TERMS OF EMPLOYMENT AND REMUNERATION - The terms of employment and the
remuneration of officers appointed by the board shall be settled by it from time
to time.

6.12 CONFLICT OF INTEREST - An officer shall disclose his interest in any
material contract or proposed material contract with the Corporation in
accordance with subsection 4.18.

6.13 AGENTS AND ATTORNEYS - The board shall have power from time to time to
appoint agents or attorneys for the Corporation in or outside Canada with such
powers of management or otherwise including the power to sub-delegate as may be
thought fit.

6.14 FIDELITY BONDS - The board may require such officers, employees and agents
of the Corporation as the board deems advisable to furnish bonds for the
faithful discharge of their powers and duties, in such form and with such surety
as the board may from time to time determine.

                                   SECTION VII

                  PROTECTION OF DIRECTORS, OFFICERS AND OTHERS

7.1 LIMITATION OF LIABILITY - No director or officer shall be liable for the
acts, receipts, neglects or defaults, of any other director or officer or
employee, or for joining in any receipt or other act for conformity, or for any
loss, damage or expense happening to the Corporation through the insufficiency
or deficiency of title to any property acquired for or on behalf of the
Corporation or for the insufficiency or deficiency of any security in or upon
which any of the moneys of the Corporation shall be invested, or for any loss or
damage arising from the bankruptcy, insolvency or tortuous acts of any person
with whom any of the moneys, securities or effects of the Corporation shall be
deposited, or for any loss occasioned by any error of judgment or oversight on
his part, or for any other loss, damage or misfortune whatever which shall
happen in the execution of the duties of his office or in relation thereto,
unless the same are occasioned by his own willful neglect or default; provided
that nothing herein shall relieve any director or officer from the duty to act
in accordance with the Act and the regulations thereunder or from liability for
any breach thereof.


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<PAGE>   9

7.2 INDEMNITY - Subject to the limitations contained in the Act, the
Corporation shall indemnify a director or officer, a former director or officer,
or a person who acts or acted at the Corporation's request as a director or
officer of a body corporate of which the Corporation is or was a shareholder or
creditor (or a person who undertakes or has undertaken any liability on behalf
of the Corporation or any such body corporate) and his heirs and legal
representatives against all costs, charges and expenses, including an amount
paid to settle an action or satisfy a judgment, reasonably incurred by him in
respect of any civil, criminal or administrative action or proceeding to which
he is made a party by reason of being or having been a director or officer of
the Corporation or such body corporate, if

     (a) he acted honestly and in good faith with a view to the best
     interests of the Corporation; and

     (b) in the case of a criminal or administrative action or proceeding that
     is enforced by a monetary penalty, he had reasonable grounds for believing
     that his conduct was lawful.

                                  SECTION VIII

                                     SHARES

8.1 ALLOTMENT - The board may, from time to time, allot or grant options to
purchase the whole or any part of the authorized and unissued shares of the
Corporation at such times and to such persons and for such consideration as the
board shall determine, provided that no share shall be issued until it is fully
paid as prescribed by the Act.

8.2 COMMISSIONS - The board may from time to time authorize the Corporation to
pay a commission to any person in consideration of his purchasing or agreeing to
purchase shares of the Corporation, whether from the Corporation or from any
other person, or procuring or agreeing to procure purchasers for any such
shares.

8.3 REGISTRATION OF TRANSFER - Subject to the provisions of the Act, no transfer
of shares shall be registered in a securities register except upon presentation
of the certificate representing such shares with a transfer endorsed thereon or
delivery therewith duly executed by the registered holder or by his attorney or
successor duly appointed, together with such reasonable assurance or evidence of
signature, identification and authority to transfer as the board may from time
to time prescribe, upon payment of all applicable taxes and any fees prescribed
by the board, upon compliance with such restrictions on transfer as are
authorized by the articles and the by-laws.


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<PAGE>   10

8.4 LIEN FOR INDEBTEDNESS - If the articles provide that the Corporation shall
have a lien on shares registered in the name of a shareholder indebted to the
Corporation, such lien may be enforced, subject to any other provision of the
articles and to any unanimous shareholder agreement, by the sale of the shares
thereby affected or by any other action, suit, remedy or proceeding authorized
or permitted by law or by equity and, pending such enforcement, may refuse to
register a transfer of the whole or any part of such shares.

8.5 SHARE CERTIFICATES - Every holder of one or more shares of the Corporation
shall be entitled, at his option, to a share certificate, or to a
non-transferable written acknowledgment of his right to obtain a share
certificate, stating the number and class or series of shares held by him as
shown on the securities register. Share certificates and acknowledgments of a
shareholder's right to a share certificate, respectively, shall be in such form
as the board shall from time to time approve. Any share certificate shall be
signed in accordance with subsection 2.4 and need not be under the corporate
seal; unless the board otherwise determines that certificates representing
shares in respect of which a transfer agent and/or registrar has been appointed
shall not be valid unless countersigned by or on behalf of such transfer agent
and/or registrar. The signature of one of the signing officers or, in the case
of share certificates which are not valid unless countersigned by or on behalf
of a transfer agent and/or registrar, the signatures of both signing officers,
may be printed or mechanically reproduced in facsimile upon share certificates
and every such facsimile signature shall for all purposes be deemed to be the
signature of the officer whose signature it reproduces and shall be binding upon
the Corporation.

8.6 REPLACEMENT OF SHARE CERTIFICATES - The board or any officer or agent
designated by the board may in its or his discretion direct the issue of a new
share certificate in lieu of and upon cancellation of a share certificate that
has been mutilated or in substitution for a share certificate claimed to have
been lost, destroyed or wrongfully taken, upon payment of such fee, not
exceeding three dollars, upon providing for the indemnification and
reimbursement of expenses and upon proof of loss of said share certificate as
the board may from time to time prescribe, whether generally or in any
particular case.

8.7 JOINT SHAREHOLDERS - If two or more persons are registered as joint holders
of any share the Corporation shall not be bound to issue more than one
certificate in respect thereof, and delivery of such certificate to one of such
persons shall be sufficient delivery to all of them. Any one of such persons may
give effectual receipts for the certificate issued in respect thereof or for any
dividend, bonus, return of capital or other money payable or warrant issuable in
respect of such share.

8.8 DECEASED SHAREHOLDERS - In the event of the death of a holder, or of one of
the joint holders, of any share, the Corporation shall not be required to make
any entry in the securities register in respect thereof or to make payment of
any dividends thereon except upon production of all such documents as may be
required by law and upon compliance with the reasonable requirements of the
Corporation and its transfer agents.


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<PAGE>   11

                                   SECTION IX

                            MEETINGS OF SHAREHOLDERS

9.1 ANNUAL MEETINGS - The annual meeting of shareholders shall be held at such
time in each year and, subject to subsection 9.3, at such place as the board,
the chairman of the board, the managing director or the president may from time
to time determine, for the purpose of considering the financial statements and
reports required by the Act to be placed before the annual meeting, electing
directors, appointing auditors and for the transaction of such other business as
may properly be brought before the meeting.

9.2 SPECIAL MEETINGS - The board, the chairman of the board, the managing
director or the president shall have power to call a special meeting of
shareholders at any time. The president or the secretary of the Corporation
shall, upon receipt of a request signed by the registered holders of at least
fifty-one percent (51%) of the issued voting shares of the Corporation, call a
special general meeting of the shareholders of the Corporation by way of written
notice given in accordance with subsection 10.1 accompanied by an agenda
specifying the date, time, place and purpose of the meeting, to be addressed to
each shareholder having the right to vote at such meeting.

9.3 PLACE OF MEETINGS - Meetings of shareholders shall be held at the registered
office of the Corporation or elsewhere in the municipality in which the
registered office is situated or, if the board shall so determine, at some other
place in Canada or, if all the shareholders entitled to vote at the meeting so
agree, at some place outside Canada.

9.4 NOTICE OF MEETINGS - Notice of the time and place of each meeting of
shareholders shall be given in the manner provided in subsection 10.1 not less
than twenty-one (21) nor more than fifty (50) days before the date of the
meeting to each director, to the auditor and to each shareholder who at the
close of business on the record date for notice, if any, is entered in the
securities register as the holder of one or more shares carrying the right to
vote at the meeting. Notice of a meeting of shareholders called for any purpose
other than consideration of the financial statements and auditor's report,
election of directors and re-appointment of the incumbent auditor shall state
the nature of such business in sufficient detail to permit the shareholder to
form a reasoned judgement thereon and shall state the text of any special
resolution to be submitted to the meeting. A shareholder and any other person
entitled to attend a meeting of shareholders may in any manner waive notice of
or otherwise consent to a meeting of shareholders, and attendance of any such
person at a meeting of shareholders is a waiver of notice of the meeting, except
when he attends a meeting for the express purpose of objecting to the
trans-action of any business on the grounds that the meeting is not lawfully
called.

9.5 MEETINGS WITHOUT NOTICE - A meeting of shareholders may be held without
notice at any time and place permitted by the Act (a) if all the shareholders
entitled to vote thereat are present in person or represented by proxy or if
those not present or represented by proxy waive notice of or otherwise consent
to such meeting being held, and (b) if the auditors and the directors are
present or waive notice of or otherwise consent to such meeting being held. At
such a meeting any business may be transacted which the Corporation at a meeting
of shareholders may transact If the meeting is held at a place outside Canada,
shareholders not present or represented by proxy but who have waived notice of
or otherwise consented to such meeting, shall also be deemed to have consented
to the meeting being held at such place.


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<PAGE>   12

9.6 CHAIRMAN, SECRETARY AND SCRUTINEERS - The chairman of any meeting of
shareholders shall be the first mentioned of such of the following officers as
have been appointed and who is present at the meeting: president, managing
director, chairman of the board, or a vice-president who is a shareholder. If no
such officer is present within fifteen (15) minutes from the time fixed for
holding the meeting, the persons present and entitled to vote shall choose one
from amongst them to be chairman. If the secretary of the Corporation is absent,
the chairman shall appoint some person, who need not be a shareholder, to act as
secretary of the meeting. If desired, one or more scrutineers, who need not be
shareholders, may be appointed by a resolution or by the chairman with the
consent of those present at the meeting.

9.7 PERSONS ENTITLED TO BE PRESENT - The only persons entitled to be present at
a meeting of shareholders shall be those entitled to vote thereat, the directors
and auditors of the Corporation and others who, although not entitled to vote,
are entitled to or required under any provision of the Act or the articles or
by-laws to be present at the meeting. Any other person may be admitted only on
the invitation of the chairman of the meeting or with the consent of those
present at the meeting.

9.8 QUORUM - A quorum for the transaction of business at any meeting of
shareholders shall be composed of those persons who are shareholders entitled to
vote thereat or a duly appointed proxyholder for an absent shareholder so
entitled, and together holding or representing by proxy more than thirty three
and one third percent (33 1/3%) of the outstanding shares of the Corporation
entitled to vote at the meeting. If a quorum is present at the opening of any
meeting of shareholders, the shareholders present or represented by proxy may
proceed with the business of the meeting notwithstanding that a quorum is not
present throughout the meeting. If a quorum is not present at the opening of any
meeting of shareholders, the shareholders present or represented by proxy may
adjourn the meeting to a fixed time and place but may not transact any other
business.

9.9 RIGHT TO VOTE - Every person shall be entitled to vote at the meeting who at
the time is entered in the securities register as the holder of one or more
shares carrying the right to vote at such meeting.

9.10 PROXIES - Every shareholder entitled to vote at a meeting of shareholders
may appoint a proxyholder, or one or more alternate proxyholders, who need not
be shareholders, to attend and act at the meeting in the manner and to the
extent authorized and with the authority conferred by the proxy. A proxy shall
be in writing executed by the shareholder or his attorney and shall conform with
the requirements of the Act.

9.11 TIME FOR DEPOSIT OF PROXIES - The board may specify in a notice calling a
meeting of shareholders a time, preceding the time of such meeting by not more
than forty-eight (48) hours excluding non-business days, before which time
proxies to be used at such meaning must be deposited. A proxy shall be acted
upon only if, prior to the time so specified, it shall have been deposited with
the Corporation or an agent thereof specified in such notice or, if no such time
is specified in such notice, unless it has been received by the secretary of the
Corporation or by the chairman of the meeting or any adjournment thereof prior
to the time of voting.


                                      E-75

<PAGE>   13

9.12 JOINT SHAREHOLDERS - If two or more persons hold shares jointly, any one of
them present in person or represented by proxy at a meeting of shareholders may,
in the absence of the other or others, vote the shares; but if two or more of
those persons are present, in person or by proxy vote, they shall vote as one on
the shares jointly held by them.

9.13 VOTES TO GOVERN - At any meeting of shareholders every question shall,
unless otherwise required by the articles or by-laws or by-law, be determined by
the majority of the votes cast on the question. In the event of a tie, either
upon a show of hands or upon a poll, the chairman of the meeting shall not be
entitled to a second or casting vote.

9.14 SHOW OF HANDS - Subject to the provisions of the Act, any question at a
meeting of shareholders shall be decided by a show of hands unless a ballot
thereon is required or demanded as hereinafter provided. Upon a show of hands
every person who is present and entitled to vote shall have one vote. Whenever a
vote by show of hands shall have been taken upon a question unless a ballot
thereon is so required or demanded, a declaration by the chairman of the meeting
that the vote upon the question has been carried or carried by a particular
majority or not carried and an entry to that effect in the minutes of the
meeting shall be prima facie evidence of the fact without proof of the number or
proportion of the votes recorded in favour of or against any resolution or other
proceeding in respect of the said question, and the result of the vote so taken
shall be the decision of the shareholders upon the said question.

9.15 BALLOTS - On any question proposed for consideration at a meeting of
shareholders, and whether or not a show of hands has been taken thereon, any
shareholder or proxyholder entitled to vote at the meeting may require or demand
a ballot. A ballot so required or demanded shall be taken in such manner as the
chairman shall direct. A requirement or demand for a ballot may be withdrawn at
any time prior to the taking of the ballot. If a ballot is taken each person
present shall be entitled, in respect of the shares which he is entitled to
vote, to that number of votes provided by the Act or the articles, and the
result of the ballot so taken shall be the decision of the shareholders upon the
said question.

9.16 ADJOURNMENT - If a meeting of shareholders is adjourned for less than
thirty (30) days, it shall not be necessary to give notice of the adjourned
meeting, other than by announcement at the earliest meeting that is adjourned.
If a meeting of shareholders is adjourned by one or more adjournments for an
aggregate of thirty (30) days or more, notice of the adjourned meeting shall be
given as for an original meeting.

9.17 RESOLUTION IN WRITING - A resolution in writing signed by all the
shareholders entitled to vote on that resolution at a meeting of shareholders is
as valid as if it had been passed at a meeting of the shareholders unless a
written statement with respect to the subject matter of the resolution is
submitted by a director or the auditors in accordance with the Act.


                                      E-76

<PAGE>   14

9.18 ONLY ONE SHAREHOLDER - Where the Corporation has only one shareholder or
only one holder of any class or series of shares, the shareholder present in
person or by proxy constitutes a meeting.

                                    SECTION X

                                     NOTICES

10.1 METHOD OF GIVING NOTICES - Any notice (which term includes any
communication or document) to be given (which term includes sent, delivered or
served) pursuant to the Act, the regulations thereunder, the articles, the
by-laws or otherwise to a shareholder, director, officer auditor or member of a
committee of the board shall be sufficiently given if delivered personally to
the person to whom it is to be given or if delivered to his recorded address or
if mailed to him at his recorded address by prepaid ordinary or air mail or if
sent to him at his recorded address by any means of prepaid transmitted or
recorded communication. A notice so delivered shall be deemed to have been given
when it is delivered personally or to the recorded address as aforesaid a notice
so mailed shall be deemed to have been given when deposited in a post office or
public letter box; and a notice so sent by any means of transmitted or recorded
communication shall be deemed to have been given when dispatched or delivered to
the appropriate communication company or agency or its representative for
dispatch. The secretary may change or cause to be changed the recorded address
of any shareholder, director, officer, auditor or member of a committee of the
board in accordance with any information believed by him to be reliable.

10.2 NOTICE TO JOINT SHAREHOLDERS - If two or more persons are registered as
joint holders of any share, any notice shall be addressed to all of such joint
holders but notice to one of such persons shall be sufficient notice to all of
them.

10.3 COMPUTATION OF TIME - In computing the date when notice must be given under
any provision requiring a specified number of days' notice of any meeting or
other event, the date of giving the notice shall be excluded and the date of the
meeting or other event shall be included.

10.4 UNDELIVERED NOTICES - If any notice given to a shareholder pursuant to
subsection 10.1 is returned on three (3) consecutive occasions because he cannot
be found, the Corporation shall not be required to give any further notices to
such shareholder until he informs the Corporation in writing of his new address.

10.5 OMISSIONS AND ERRORS - The accidental omission to give any notice to any
shareholder director, officer, auditor or member of a committee of the board or
the non-receipt of any notice by any such person or any error in any notice not
affecting the substance thereof shall not invalidate any action taken at any
meeting held pursuant to such notice or otherwise founded thereon.

10.6 PERSONS ENTITLED BY DEATH OR OPERATION OF LAW - Every person who, by
operation of law, transfer, death of a shareholder or any other means
whatsoever, shall become entitled to any share shall be bound by every notice in
respect of such share which shall have been duly given to the shareholder from
whom he derives his title to such share prior to his name and address being
entered on the securities register (whether such notice was given before or
after the happening of the event upon which he became so entitled) and prior to
his furnishing to the Corporation the proof of authority or evidence of his
entitlement prescribed by the Act.


                                      E-77

<PAGE>   15

10.7 WAIVER OF NOTICE- Any shareholder (or his duly appointed proxyholder),
director, officer auditor or member of a committee of the boars may at any time
waive notice, or waive or abridge the time for any notice, required to be given
to him under any provision of this Act, the regulations thereunder, the
articles, the by-laws or otherwise and such waiver or abridgement shall cure any
default in the giving or in the time of such notice, as the case may be. Any
such waiver or abridgement shall be in writing except a waiver of notice of a
meeting of shareholders or of the board which may be given in any manner.

                                   SECTION XI

                                 EFFECTIVE DATE

1.19 EFFECTIVE DATE - This by-law shall come into force when confirmed by the
     shareholders in accordance with the Act.

ENACTED by the board the 30th day of May 1995.

The President,                           The Secretary.

/s/      Paul Averback                   /s/      Pierre Barnard
- -----------------------------            ------------------------------


CONFIRMED by the shareholders in accordance with the Act the 30th day of May
1995.

                          The Secretary,

                          /s/     Pierre Barnard
                          ------------------------------


                                      E-78




<PAGE>   1


EXHIBITS 5.1 & 23.2

                                FOLEY & LARDNER

                                ATTORNEYS AT LAW

<TABLE>
<S>                                                 <C>                                                  <C>
CHICAGO                                                       FIRSTAR CENTER                                       SACRAMENTO
DENVER                                                  777 EAST WISCONSIN AVENUE                                   SAN DIEGO
JACKSONVILLE                                         MILWAUKEE, WISCONSIN 53202-5367                            SAN FRANCISCO
LOS ANGELES                                              TELEPHONE (414) 271-2400                                 TALLAHASSEE
MADISON                                                  FACSIMILE (414) 297-4900                                       TAMPA
MILWAUKEE                                                                                                    WASHINGTON, D.C.
ORLANDO                                                                                                       WEST PALM BEACH

                                                          WRITER'S DIRECT LINE
                                                               414/297-5658

EMAIL ADDRESS                                                                                            CLIENT/MATTER NUMBER
[email protected]                                                                                             018792/0101

                                                           February 10, 2000
</TABLE>

Nymox Pharmaceutical Corporation
9900 Cavendish Boulevard, Suite 306
St. Laurent, QC, Canada H4M 2V2

        Re:  Registration Statement on Form F-3 Under the Securities Act of 1933

Ladies and Gentlemen:

We have acted as United States counsel for Nymox Pharmaceutical Corporation, a
Canadian corporation ("Nymox"), in connection with the preparation and filing of
a Registration Statement with the Securities and Exchange Commission on Form F-3
(the "Registration Statement") under the Securities Act of 1933, as amended (the
"Act"), registering the resale of shares of Nymox common shares (the "Shares")
which may be issued to Jaspas Investment Ltd. ("Jaspas") pursuant to (i) a
Common Stock Purchase Agreement (the "Agreement") between Nymox and Jaspas, and
(ii) a warrant held by Jaspas to purchase 200,000 Shares.

We have examined copies of the Agreement together with the exhibits and
schedules attached as a part thereof (collectively, the "Transaction
Documents"). We have examined such certificates of public officials, such
certificates of officers of Nymox and originals or copies certified to our
satisfaction as being true copies of such other documents as we have deemed
relevant and necessary as a basis for this opinion, including the Certificate of
Incorporation and Bylaws of Nymox, resolutions of its Board of Directors and
such other documents as we have deemed relevant and necessary as a basis for our
opinions hereinafter set forth. We have relied, to the extent we deem such
reliance proper, upon such certificates of public officials and of officers of
Nymox, and other statements and information furnished by officers of Nymox with
respect to the accuracy of material factual matters contained therein.
Specifically, we have assumed the accuracy, validity and completeness of all
corporate records and information made available to us by Nymox, and upon which
we rely.


                                      E-79



<PAGE>   2

In our examination, we have assumed the genuineness of all signatures, the
authenticity of all documents submitted to us, the conformity to original
documents of all documents submitted to us as certified or photostatic copies,
and the authenticity of the originals of such latter documents.

As to matters of fact relevant to this opinion, we have relied solely upon and
assume the current accuracy of (a) our examination of the documents referred to
above, and our actual knowledge, (b) the information obtained from public
officials and records included in the documents referred to above, and (c) the
representations and warranties of Nymox and Jaspas set forth in the Agreement
and the Transaction Documents, and any certificates delivered to us by officers
of Nymox or Jaspas. We have made no independent investigations or other attempts
to verify the accuracy of any such information, representations or warranties,
or to determine the existence or non-existence of any other factual matters;
however, we are not aware of any facts that would lead us to believe that any of
the opinions expressed herein are not accurate.

In rendering the opinions contained herein, we have relied on the opinions of
Stikeman Elliot on all matters which are affected by Canadian laws or
regulations, a copy of which opinion is attached hereto.

All of the above assumptions and reliances are made with your consent.

Based on the foregoing and subject to the qualifications hereinafter set forth,
it is our opinion that all necessary corporate action has been taken by Nymox to
validly issue the Shares. Upon their issuance in accordance with the terms of
the Agreement and Transaction Documents, the Shares will be validly issued and
outstanding and fully paid and non-assessable shares in the share capital of
Nymox.

The opinions set forth herein are given as of the date hereof and we disclaim
any obligation or undertaking to advise you of any change in law or fact
affecting or bearing upon the opinions rendered herein occurring after the date
hereof which may come, or be brought, to our attention.

We consent to the filing of this opinion letter as an exhibit to the
Registration Statement and the reference to this firm under the caption "Certain
Legal Matters" in the Prospectus included as part of the Registration Statement.

                        Yours truly,

                        FOLEY & LARDNER

                        By  /s/ Foley & Lardner
                          -----------------------------------------


                                      E-80




<PAGE>   1

EXHIBIT 5.2 & 23.3

                               STIKEMAN, ELLIOTT
                            BARRISTERS & SOLLICITORS
                                   40TH FLOOR
                          1155 RENE-LEVESQUE BOUL. W.
                          MONTREAL, QC, CANADA H3B 3V2

Foley & Lardner
777 East Wisconsin Avenue                                      February 10, 2000
Milwaukee, Wisconsin 53202
USA

                   Re:      Nymox Pharmaceutical Corporation
                   -----------------------------------------

Dear Sirs:

         We have acted as Canadian counsel to Nymox Pharmaceutical Corporation,
a Canadian corporation ("NYMOX"), in connection with (i) the Common Stock
Purchase Agreement dated as of November 1, 1999 (the "PURCHASE AGREEMENT") by
and between Nymox and Jaspas Investments Limited ("JASPAS") pursuant to which
Jaspas (a) has committed to purchase common shares of Nymox (the "SHARES"), over
a period of time, upon periodic requests of Nymox, and (b) has been granted a
warrant (the "WARRANT") to purchase up to 200,000 common shares (the "WARRANT
SHARES") of Nymox (collectively, the "TRANSACTION"), and (ii) the preparation of
a registration statement on Form F-1 (the "REGISTRATION STATEMENT") under the
Securities Act of 1933, as amended (the "SECURITIES ACT"), registering the
resale of the Shares and the Warrant Shares to be issued to Jaspas in the
Transaction.

         For the purposes of rendering this opinion, we have reviewed the
following agreements and instruments: (a) the Purchase Agreement; (b) the
Warrant; (c) the Registration Rights Agreement between Jaspas and Nymox, dated
as of November 1, 1999 (the "REGISTRATION RIGHTS AGREEMENT"); and (d) the Escrow
Agreement between Jaspas, Nymox and Epstein Becker & Green, P.C., dated as of
November 1, 1999 (the "ESCROW AGREEMENT") (the Purchase Agreement, the Warrant,
the Registration Rights Agreement and the Escrow Agreement are referred to
collectively herein as the "TRANSACTION DOCUMENTS"). We have not participated in
the preparation of the Transaction Documents, nor of any other document or
agreement related thereto.

         We have examined originals or copies, certified or otherwise identified
to our satisfaction, of the Transaction Documents, the certificate and articles
of incorporation of Nymox, the by-laws of Nymox, resolutions of the directors of
Nymox relating to the Transaction Documents and related documents and such
public and corporate records, certificates, instruments and other documents and
papers, and have made such examinations and investigations of law as we have
considered necessary or desirable as a basis for the opinions hereinafter
expressed.


                                      E-81
<PAGE>   2

         For the purposes of the opinion as to the existence of the Purchaser
set forth in paragraph 1 hereunder, we have relied exclusively upon a
Certificate of Compliance dated February 8, 2000 provided pursuant to subsection
263(2) of the Canada Business Corporations Act (the "CBCA"), a copy of which
certificate is attached hereto as Schedule "A". For the purposes of certain
questions of fact material to our opinion, and without any independent
investigation or inquiry, we have relied upon a certificate of an officer of
Nymox as at the date hereof, an original copy of which is attached hereto as
Schedule "B" (the "OFFICER'S CERTIFICATE").

         In our examination of such documents, we have assumed:

         the genuineness of all signatures on, and the authenticity and
completeness of, all documents submitted to us, and the conformity to authentic
original documents of all documents submitted to us as certified, photostat or
similarly reproduced copies of such original documents;

         the completeness, truth and accuracy of all facts set forth in the
official public records, certificates and documents supplied by public officials
or otherwise conveyed to us by public officials;

         the completeness, truth and accuracy of all facts set forth in the
certificates supplied by the respective officers and directors of Nymox
including, without limitation, the Officer's Certificate;

         that each of the parties or signatories to any of the Transaction
Documents, other than Nymox, has the necessary power, capacity and authority to
execute, deliver and perform each such Transaction Document, has taken all
necessary actions to authorize the execution, delivery and performance by it of
each such Transaction Document and has duly executed and delivered each such
Transaction Document and that each such Transaction Document constitutes legal,
valid and binding obligations of such parties enforceable against them in
accordance with its terms.

         Our opinions expressed herein are limited to matters governed by the
laws of the Province of Quebec and the laws of Canada applicable therein. We do
not express any opinion with respect to the laws of any other jurisdiction.

          Based and relying upon the foregoing, and subject to the qualification
set forth below, we are of the opinion that:

1.        Nymox is a corporation incorporated and validly existing under the
          CBCA and has all necessary corporate power and authority to enter into
          the Transaction Documents and to perform its obligations thereunder;


                                      E-82


<PAGE>   3

2.       The execution and delivery of and performance by Nymox of the
         Transaction Documents and the consummation of the transactions
         contemplated thereby, including the issuance of the Shares and the
         Warrant Shares, have been authorized by all necessary corporate action
         on the part of Nymox, and no further consent or authorization of Nymox
         or its Board of Directors or shareholders is required.

3.       Each of the Transaction Documents has been duly executed and, to the
         extent delivery thereof is a matter of the laws of Quebec, delivered by
         Nymox.

4.       The Shares and Warrant Shares to be issued pursuant to the Purchase
         Agreement or the Warrant, when the amounts payable under the Purchase
         Agreement or the Warrant, as the case may be, is paid and such Shares
         or Warrant Shares, as the case may be, are issued as provided therein,
         will be validly issued by Nymox and will be outstanding as fully paid
         and non-assessable common share in the share capital of Nymox.

5.       All necessary documents have been filed, all requisite proceedings have
         been taken and all approvals, permits, exemptions, consents, orders and
         authorizations of the Quebec Securities Commission required under the
         securities laws of Quebec have been obtained in order to qualify the
         Shares and the Warrant Shares for issuance to Jaspas.

         The opinions set forth above are qualified as follows: (a) the Quebec
Securities Commission has the authority under the Securities Act (Quebec) to
deny the benefit of an exemption otherwise provided in that Act where it
considers it necessary to do so to protect investors; and (b) the report
required to be filed with the Quebec Securities Commission with respect to the
Purchase Agreement was filed beyond the ten-day period of time within which such
report was required to be filed, and we express no opinion as to the effect of
such delay on the availability of the statutory exemption relied upon.

         This opinion is solely for the benefit of the addressee and not for the
benefit of any other person. It is rendered solely in connection with the
transactions to which it relates. It may not be quoted, in whole or in part, or
otherwise referred to or used for any purpose without our prior written consent.
The addressee may annex this opinion to its own opinion to be delivered in
connection with the completion of the arrangements contemplated in the Purchase
Agreement.

         We consent to the filing of this opinion as an exhibit to the
Registration Statement and to the reference to this firm name under the caption
"Certain Legal Matters" in the prospectus included as part of the Registration
Statement.

                                               Yours truly,

                                               /s/ Stikeman Elliott
                                               --------------------
                                                   Stikeman Elliott


                                      E-83


<PAGE>   4

================================================================================

                        NYMOX PHARMACEUTICAL CORPORATION

                             OFFICER'S CERTIFICATE

================================================================================


TO:      Stikeman, Elliott

         The undersigned, Roy Wolvin, secretary of Nymox Pharmaceutical
Corporation (the "CORPORATION"), hereby certifies as follows, intending that the
same may be relied upon by you in connection with your opinion of even date
herewith without further inquiry:

1.       The minute books and corporate records of the Corporation relating to
the proceedings of the shareholders and directors of the Corporation, which have
been made available to Stikeman, Elliott, are the original minute books and
corporate records of the Corporation and contain all minutes of meetings,
resolutions, by-laws and proceedings of the shareholders and directors of the
Corporation to the date hereof and there have been no meetings, resolutions,
by-laws or proceedings authorized or passed by the shareholders or directors of
the Corporation to the date hereof not reflected in such minute books and
corporate records. Such minute books and corporate records are true, complete
and correct in all respects and there are no changes, additions or alterations
necessary to be made thereto to make such books and corporate records true,
complete and correct.

The Corporation is not insolvent and has not been dissolved and no acts or
proceedings have been taken by or against the Corporation or are pending in
connection with, and the Corporation has not received notice in respect of and
is not in the course of or contemplating, any liquidation, winding-up,
dissolution, bankruptcy, insolvency or reorganization.

The Corporation has not taken any steps to terminate its existence, amalgamate,
to continue in any other jurisdiction or to change its corporate existence in
any way. The Corporation has not received any notice of any proceedings to
cancel its certificate of incorporation or otherwise to terminate its existence.
The Corporation has not received any notice or other communication from any
person or governmental authority indicating that there exists any situation
which, unless remedied, could result in the termination of its existence.

IN WITNESS WHEREOF, I have signed this 10th day of February, 2000.

                                    /s/ Roy Wolvin
                                    --------------------------------------------
                                    Roy Wolvin


                                      E-84



<PAGE>   1

EXHIBIT 10.1

                              EMPLOYMENT AGREEMENT

                  THIS AGREEMENT made as of the 8th day of January, 2000 by and
between Nymox Pharmaceutical Corporation, a Canadian corporation (the
"Company"), and Judith Fitzpatrick (the "Executive").

                             W I T N E S S E T H :

WHEREAS the Company is this day purchasing from the Executive all of her common
shares of Serex, Inc., a New Jersey corporation, and thereby acquiring a
controlling interest in Serex, Inc.;

WHEREAS, the Executive is this day receiving 187,951 shares of the common stock
of the Company and a warrant to purchase 115,662 shares of the common stock of
the Company as consideration for the purchase of her Serex common stock, subject
to the terms of the Share Purchase Agreement between the Company and the
Executive;

WHEREAS, the Company wishes to retain the services of the Executive as a
Vice-President of the Company to continue her development work on the Company's
7C Gold test and to continue to direct the scientific endeavors of Serex Inc.
and to act as President of Serex, Inc.;

WHEREAS, the Executive wishes to provide her services to the Company on the
terms set out below in this Employment Agreement and acknowledges that the
Company is reasonably relying upon Executive's execution of this Agreement as
part of its decision to purchase her shares of Serex, Inc.;

NOW, THEREFORE, in consideration of the covenants and agreements of the parties
herein contained, and as an inducement to the Company to close the purchase of
the Executive's shares of Serex, Inc., the Company and the Executive agree as
follows:

1.       Employment.

The Company hereby employs the Executive and the Executive hereby accepts
appointment as Vice-President of the Company. The Executive agrees to remain in
the employment of the Company on the terms and conditions set out below in this
Agreement. Paragraph 6 of this Agreement sets out the Executive's duties.

2.       Term.

The initial term of this Employment Agreement shall be four years, commencing on
January 8th, 2000 and expiring on January 8th, 2004 unless terminated earlier
pursuant to paragraph 13 below or extended as provided in this paragraph. At the
end of the initial term of the Agreement (or the end of the term of any
automatic renewal of this Agreement), the term of this Agreement shall be
automatically renewed for an additional term of one year unless either the
Company or the Executive gives the other party notice at least 30 days prior to
the end of the term of its/her intention not to renew the Agreement.


                                      E-86


<PAGE>   2

3.       Salary and Other Compensation.

(a)      As part of the Executive's compensation for services to be rendered
under this Agreement, the Company shall pay the Executive an annual salary at
the rate of One Hundred and Twenty-five Thousand Dollars ($125,000) (as adjusted
upward at the discretion of the Compensation Committee of the Board of Directors
of the Company from time to time) payable, as nearly as practicable, in equal
semimonthly installments. The Company agrees to review the Executive's salary at
least once in every year during the term of this Agreement and adjust it upward
accordingly in order to ensure that the Executive's salary is always more than
any other employee under her supervision. The Executive's salary, once
increased, shall not be later reduced.

(b)      [Confidential]

4.       Options.

Further as part of the Executive's compensation, the Company shall grant the
Executive an option to purchase at any time or from time to time after their
vesting dates and on or before December 23, 2009 (the "Expiry Date") 40,000
common shares of the Company in accordance with the Nymox Share Option Plan, a
copy of which is attached to and forms part of this Agreement as Schedule A (the
"Option Plan"). At the Expiry Date, the option hereby granted and still in
effect shall expire and terminate and be of no further force or effect as to the
optioned shares in respect of which the option hereby granted has not been
exercised.

The exercise price of each option shall be $3.70 per share, vesting as follows:

          - 10,000 on the first anniversary of the date of this Employment
            Agreement;

          - 10,000 on the second anniversary of the date of this Employment
            Agreement;

          - 10,000 on the third anniversary of the date of this Employment
            Agreement; and

          - 10,000 on the fourth anniversary of the date of this Employment
            Agreement.

In the event that options granted to other executives or officers of the Company
are repriced or otherwise adjusted downward in the future, the options granted
the Executive under this Agreement shall be afforded the same proportionate
treatment on a percentage-wise basis as those treated most favorably pursuant to
the repricing or other adjustments.


                                      E-87


<PAGE>   3

5.       Additional Benefits and Reimbursement of Expenses.

5.1      The Company shall provide the following additional benefits to the
         Executive during the term of this Agreement:

         (i)    20 working days of paid vacation per year (non-cumulative);

         (ii)   up to 10 paid sick days per year (non-cumulative);

         (iii)  5 paid days per year for attendance at scientific conferences,
                professional, industry and investigator conferences and studies
                of the Executive's choice (non-cumulative);

         (iv)   health care benefits, either in the form of a $5,000 health care
                allowance or coverage under the Company's health care plan; and

         (v)    such other benefits as the Company's Board shall lawfully adopt
                and approve for the Executive.

5.2      The Company shall pay or reimburse the Executive for all reasonable
         expenses actually incurred by the Executive or paid by the Executive
         during the term of the Agreement for expenses in connection with
         Company business, including:

                - travel expenses, including air and rail fare and, when
                  overnight stay is required, hotel accommodation and personal
                  meals (meals not exceeding $50.00 per day);

                - telephone expenses, including long distance calls from
                  personal phones; and

                - office supplies including stationary but not including office
                  equipment.

         Expense claims are payable upon timely presentation of an expense
         report together with such bills, expenses, statements, vouchers or such
         other supporting information as the Company may reasonably require.

6.       Duties.

The duties of the Executive shall include:

         - participation on a scientific basis with the Company's research and
           development work on drugs for the prevention, treatment and delay of
           onset of Alzheimer's disease, antimicrobial treatments and other
           therapeutic and scientific projects;

         - continuing scientific, regulatory and commercial development of the
           Company's 7C Gold Test for Alzheimer's disease;

         - scientific, regulatory and commercial development of the diagnostic
           projects of the Company and of Serex, Inc.;

         - acting as the President of Serex, Inc.;


                                      E-88


<PAGE>   4

         - directing the scientific endeavors of Serex, Inc.;

         - the management and development of Serex, Inc.'s ongoing research,
           product development, intellectual property, and technologies,
           including its proprietary SARA technology and its ongoing development
           of diagnostic assays; and

         - attendance at scientific conferences, professional, industry and
           investigator conferences and studies at the Company's request.

The Executive shall report to the President and C.E.O. of the Company and/or a
delegate to be appointed from time to time. The President and C.E.O. of the
Company may change these duties or assign new duties to the Executive from time
to time not inconsistent with the terms of this Agreement. The Executive agrees
to devote her full business time and effort to the diligent and faithful
performance of such duties.

7.       Place of Employment.

The Executive's principal place of employment shall be in the Maywood, New
Jersey area and the Company shall not relocate her principal place of employment
to a new location more than 50 miles from Maywood, New Jersey without her prior
written approval. The Executive acknowledges that her duties may require her
traveling to Montreal on a regular basis and other traveling as a necessary
incident of her employment.

8.       Confidentiality.

(a) The Executive acknowledges that during the course of her employment with the
Company she may have access to confidential and/or proprietary technical,
scientific or business information relating to the Company's research, product
development, marketing, sales, services, financing and other business or
scientifically related activities and that it is vital to the Company to
preserve the confidentiality of its technical, scientific and business affairs
and to maintain its intellectual properties, including trade secrets, know-how
and patent applications.

(b) Accordingly, as a condition of the Executive's employment, the Company and
the Executive agree as follows:

         1.  In this Agreement,

                  "Confidential Information" means any information or data
                  relating to, arising out of or in connection with the
                  research, technology, intellectual property, know-how,
                  improvements, equipment, formulas, designs, processes, product
                  development, packaging, products, distribution methods,
                  marketing, customers, financing and/or business of the
                  Company;


                                      E-89


<PAGE>   5

          "Company" means Nymox Pharmaceutical Corporation, Nymox Corporation
and their affiliates and includes their successors and assigns;

          "Company Property" means any property owned by the Company and
includes (but not limited to):

                           (a) laboratory equipment, reagents, samples,
                           specimens, standards, protocols, requisitions, test
                           results, drug candidates, cell lines, notebooks,
                           papers, presentations and publications;

                           (b) computer equipment, software, files, disks,
                           cd-roms, tapes and all other electronic means of
                           storing data or information;

                           (c) cell phones, pagers, answering machines,
                           telephones and other telecommunication equipment;

                           (d) office equipment, office furniture,
                           correspondence, memoranda, reports, faxes, files,
                           books, magazines, stationary, messages, e-mails,
                           contracts, patent documents, customer lists, supplier
                           lists, brochures, marketing material, displays,
                           posters and financial reports; and

                           (e) credit cards, calling cards, bank cards,
                           checkbooks, deposit books, bank statements, financial
                           records, canceled checks, receipts, invoices, bills
                           and accounts.

         2. The Executive shall keep in strict confidence any Confidential
         Information and not to disclose it to any third party except as
         required by law, regulation, legal process or other governmental
         authority, as permitted this Agreement or with the written consent of
         the President of the Company.

         3. The Executive shall take reasonable care to maintain all
         Confidential Information in confidence and shall inform the Company
         immediately upon the discovery of any unauthorized disclosure or use of
         any Confidential Information and take reasonable steps to prevent any
         further unauthorized disclosure or use.

         4. The Executive shall not use any Confidential Information for any
         purpose other than the performance of her/his duties as an officer and
         employee of the Company.

         5. Confidential Information shall not include information which:

         (i)   was known to the Executive prior to receipt by Executive of any
               Confidential Information hereunder;

         (ii)  was known or has become known to the public through lawful
               disclosure; or

         (iii) a third party having the right to disclose such information has
               lawfully disclosed such information to the Executive.


                                      E-90


<PAGE>   6

9.       Company Property.

(a)      The Executive acknowledges and agrees that the Company owns completely

         (i)      all past, present and future patent rights, trade secrets,
                  know-how, copyright, trademarks, industrial designs and other
                  intellectual property rights related to, connected with or
                  arising out of scientific projects undertaken at or by the
                  Company or funded by the Company, and

         (ii)     all patent, trademark, copyright, trade secrets, know-how,
                  industrial designs and other intellectual property rights to
                  scientific, research and development or commercial work
                  already performed, being performed or to be performed in the
                  future by the Executive in the course of or during the term of
                  her employment at the Company.

(b) The Executive agrees to disclose to the Company in a timely manner any
inventions, discoveries, ideas or research findings, whether patentable or not,
relating to, connected with or arising out of her employment with the Company or
related to or connected with the business of the Company.

(c) The Executive agrees to assign completely, exclusively and irrevocably to
the Company any and all rights, interests and title to any inventions,
discoveries and ideas, whether patentable or not, (including, but not limited to
patent applications, patents, trademarks, copyrights, trade secrets, know-how,
industrial designs, or other intellectual property rights) relating to,
connected with or arising out of her employment with the Company, related to or
connected with the business of the Company, or conceived or reduced to practice
at any time during the Executive's employment by the Company, either solely or
jointly with others and whether or not developed on the Executive's own time or
with the resources of the Company.

The Executive further agrees, on request by the Company, both during the term of
her employment with the Company and after termination of that employment, to
execute any patent, copyright, trademark, trade secrets or industrial design
assignments, applications, certificates, affidavits or other documents that, in
the opinion of the Company, are necessary to secure, protect or evidence the
Company's intellectual property rights.

 (d) The Executive shall not use Company Property except for the purposes of
employment or as otherwise authorized. The Executive shall not, except for the
Company's use, copy or duplicate any Company documents or property, nor remove
them from the Company's facilities, nor use any information concerning them
except for the Company's benefit, either during her employment or thereafter.

(e) Upon the Company's request or upon termination of employment, the Executive
shall promptly:

         (i)      return any Confidential Information that is in tangible form
                  and any Company Property in her possession or under her
                  control without making or retaining any copies; and


                                      E-91


<PAGE>   7

         (ii)     provide any passwords to computer files, systems or networks
                  or codes for any research or clinical trials used by the
                  Executive in the course of her employment.

(f) Nothing in this Employment Agreement shall be construed as transferring,
assigning or conveying to the Company any rights, interests and title to any
inventions, discoveries, patent applications, patents, trademarks, copyrights,
trade secrets, know-how, industrial designs, or other intellectual property
rights that the Executive and/or Serex, Inc. had prior to the date of this
Agreement, other than those intellectual property rights and interests relating
to the Company's AD7C(TM) test.

10.      Conflicts of Interest.

(a)      During the term of her employment with the Company, the Executive
         agrees:

         (i)      not to engage in any other employment or business or act as an
                  officer or director of or consult with any other company,
                  business or person, other than a non-profit corporation or
                  organization, except with the prior approval of the President
                  of the Company, which approval will not be unreasonably
                  withheld;

         (ii)     to promptly disclose to the President of the Company any
                  business opportunities that come to the attention of the
                  Executive and that relate to the pharmaceutical or diagnostic
                  business, including (but not limited to) research proposals,
                  licensing opportunities, patent applications and assignments,
                  co-marketing ventures, technology transfers and employment
                  opportunities.

(b) The Executive agrees that, during the term of her employment and for one
year after the date of termination of employment unless such termination is
pursuant to paragraphs 13(a)(iv) or 13(a)(v), she will not, directly or
indirectly, own, manage, operate, control or participate in the ownership,
management, operation or control of, or be connected as an officer, executive,
partner, director or otherwise with, or have any financial interest in, or aid
or assist anyone else in the conduct of, any business that markets a diagnostic
for Alzheimer's disease or that is substantially similar to or competitive with
the Company's present business or any other business at which the Company may
substantially engage during the term of the Executive's employment, provided,
however, that the Executive may own not more than 4.9% of the equity securities
of a corporation, trading on a public stock exchange .

(c) The Executive further agrees that, during the term of her employment and for
one year after the date of termination of employment, she will not solicit or
assist, directly or indirectly, any employee of the Company to terminate his or
her employment with the Company or to divert any intellectual property, trade
secrets, business or customers from the Company.

(d) The Executive agrees that all restrictions in this article are reasonable,
valid and do not go beyond what is necessary to protect the interests of the
Company, and waives all defenses to their strict enforcement. The Executive
acknowledges that the market for diagnostic tests and kits and for therapeutic
drugs that the Company is presently marketing and/or developing is worldwide and
that any specific geographic restriction in this article would be unenforceable.


                                      E-92


<PAGE>   8

(e) The provisions of this article are only intended to safeguard against the
Executive participating in competitive endeavors against the Company and shall
not in any way restrict or limit the Executive from engaging in, employment by
or consulting with subsequent businesses which are not in direct competition
with the Company. In particular, the Executive may engage in the development of
immunoassays, strip assays and diagnostic kits that are not designed to detect a
unique or proprietary marker for any condition for which the Company was
developing diagnostic tests, kits or assays during the term of her employment.

(f) The parties agree that if any covenant or provision in this article is
determined to be void or unenforceable at law due to period of time,
geographical area, or otherwise, then such covenant or provision shall be
reduced in scope or amended, as to term, geographical area or otherwise, to the
extent required so that the covenant or provision, as so reduced or amended, is
enforceable at law and the unenforceable part shall be deemed to be severed from
the balance, which balance shall survive and be of full force and effect.

11.      Communications.

(a) The Executive agrees that the Company may treat any communications
(including, but not limited to, mail, telephone messages, e-mail messages and
voice mail) or item (including, but not limited to, reagents, specimens, and
samples) addressed to the Executive and received at one of the Company's
offices, laboratories or research facilities or through its e-mail, voice mail
or other telecommunication systems as a communication or item relating to,
arising out of or in connection with the Company's business and may open, review
and/or inspect the communication or item in order to determine, in its sole
discretion, whether the communication or item relates to, arises out of or is
connected with Nymox's business. If the Company so determines, then the Company
may retain and use the communication or item as it sees fit.

(b) The Executive agrees not to release or disclose to any third party any
publications, presentations or press releases relating to, arising out of or in
connection with the Company's business, research and development, technology or
collaborations with other researchers, institutions or businesses without the
prior approval of the President of the Company.

12.      Provisions Which Survive the Termination of this Agreement.

The provisions of this Agreement contained in Articles 8 (Confidentiality), 9
(Company Property), 10 (Conflicts of Interest) and 11 (Communications) shall
survive the termination of the Executive's employment.


                                      E-93


<PAGE>   9

13.      Termination of Employment.

(a) The Executive's employment shall terminate, or be subject to termination,
prior to the term specified in Article 2 hereof, as follows:

         (i) The Executive's employment shall terminate upon death.

         (ii) If, during the term of this Agreement, the Executive has a
         Disability, the Company may, at any time after the Executive has a
         Disability, terminate the Executive's employment by written notice to
         her. In the event that the Executive's employment is terminated, this
         Agreement shall terminate except that the Company shall continue to pay
         the Executive's salary for a period of six (6) months from the date of
         termination of her employment and maintain her health care benefits for
         the balance of the term of this Agreement, as if the Executive had not
         been terminated for Disability. As used in this Agreement, "Disability"
         shall mean the inability of the Executive to perform the Executive's
         duties of employment for the Company, pursuant to the terms of this
         Agreement, because of physical or mental disability, where such
         disability shall have existed for a period of more than 90 consecutive
         days or an aggregate of 120 days in any 365-day period. The existence
         of a Disability means that the Executive's mental or physical
         disability substantially interferes with the performance of her
         substantive duties for the Company as specified in this Agreement. The
         fact of whether or not a Disability exists hereunder shall be
         determined by professionally qualified medical experts selected by the
         Board and reasonably acceptable to the Executive or her agent.

         (iii) The Company may, at any time, terminate the Executive's
         employment for cause. For the purposes of this Agreement, the Company
         shall have cause to terminate the Executive's employment hereunder
         upon:

                  (A) the Executive engaging in misconduct which is injurious to
                  the Company;

                  (B) any material breach of this Agreement by the Executive
                  that is not cured by the Executive within thirty (30) days
                  after the Company has given the Executive written notice
                  specifying the particulars of the breach of the Agreement and
                  its intent to terminate her employment if the breach is not
                  cured; or

                  (C) the Executive's conviction of a felony or a plea by the
                  Executive of nolo contendere to a felony.

         (iv) The Company may terminate the Executive's employment without cause
         upon forty-five (45) days prior written notice to the Executive or upon
         payment of forty-five days salary in lieu of notice. Termination of the
         Executive's employment by the Company for any reason, other than
         specified in paragraphs 13(a)(i), (ii) or (iii) shall constitute
         termination of this Agreement without cause.

         (v) The Executive may terminate her employment for Good Reason upon
         forty-five (45) days prior written notice to the Company. If the
         Executive's employment is terminated pursuant to this Section,
         13(a)(v), the Executive shall be entitled to receive those severance
         payments and other benefits as if the Executive was terminated pursuant
         to Section 13(a)(iv) of this Agreement. Good Reason means:


                                      E-94


<PAGE>   10

                  (A) the assignment by the Company to the Executive of duties
                  which are materially different than those of the Vice
                  President of the Company as described in Article 6 of this
                  Agreement, where the Company has not resolved the Executive's
                  objections to the assignment within sixty (60) days after
                  written notice from the Executive specifying her objections to
                  the assignment and her intent to terminate her employment on
                  that ground if not resolved to her reasonable satisfaction;
                  and

                  (B) any material breach of this Agreement by the Company that
                  is not cured by the Company within thirty (30) days after the
                  Executive has given the Company written notice specifying the
                  particulars of the breach of the Agreement and her intent to
                  terminate her employment if the breach is not cured.

(b) In the event of the termination of the Executive's employment pursuant to
paragraphs 13(a)(iv) or 13(a)(v), the Executive shall be entitled to receive, in
lieu of any other compensation or payment as a result of such termination,
severance payments in an amount equal to the lesser of twelve months of the
Executive's salary and all other benefits provided to the Executive under this
Agreement at the time of termination or the balance of that salary remaining on
the term of this Agreement and all other benefits provided to the Executive
under this Agreement. The severance payments will be payable, as nearly as
practicable, in equal semimonthly installments and shall cease in the event the
Executive finds new employment in the pharmaceutical or diagnostic industry.
During the severance payment period, the Executive agrees to comply with the
provisions of paragraph 10(b).

(c) In the event of the termination of the Executive's employment, all payments
of salary and benefits under Articles 3 and 5 of this Agreement, other than
payments of salary or benefits owed or accruing to the Executive prior to the
termination, shall cease, and the Executive shall not be entitled to receive any
compensation, benefits or payment on account of such termination, except as
otherwise provided in paragraphs 13(a)(ii) and 13(b). The Executive shall be
entitled to receive those benefits which by their terms continue after
termination of employment in accordance with the terms of such benefits
applicable after termination of employment as required by applicable law.

14.      Miscellaneous.

(a)      Notices

Any notice or other communication required by this Agreement shall be in writing
and shall be effective if hand delivered or if sent by certified or registered
mail or by facsimile transmission to the following locations until notified
otherwise in writing.

Nymox Pharmaceutical Corporation

                  Attention: President
                  Nymox Pharmaceutical Corporation
                  9900 Boul. Cavendish, Suite 306
                  Saint Laurent, Quebec, Canada, H4M 2V2
                  FAX: (514) 332-2227


                                      E-95


<PAGE>   11

The Executive:

                  Judith Fitzpatrick Davis
                  c/o Serex, Inc.
                  230 West Passaic Street
                  Maywood, New Jersey
                  FAX:     201-368-7850

A notice is effective on the date of delivery to the Party. Delivery is deemed
to have occurred on the day of delivery by courier, or upon facsimile
transmission with confirmation, or on the fifth day after the date of sending
the notice by registered mail.

(b)               Governing Law

This Agreement shall be interpreted and enforced in accordance with the
substantive laws of the State of New Jersey. The Executive acknowledges that her
violation, or threatened violation, of the provisions of Articles 8
(Confidentiality), 9 (Company Property), 10 (Conflicts of Interest) and 11
(Communications) would cause the Company irreparable injury and, in addition to
any other remedies to which the Company may be entitled, the Company shall be
entitled to immediate injunctive relief in addition to any remedy available
through the arbitration procedures set out below in paragraph 14(c).

(c)               Dispute Resolution

In the event of any controversy or claim arising out of or relating to any
provisions of this Agreement or the breach thereof, the Parties shall try to
settle those conflicts amicably between themselves. Should they fail to agree,
the matter in dispute shall be settled through arbitration conducted by and in
accordance with the rules of the American Arbitration Association ("A.A.A.").

Either Party may furnish the other party with a dated, written notice (the
"Arbitration Notice") indicating (i) intent to commence arbitration proceedings,
(ii) the nature, with reasonable detail, of the dispute, (iii) the amount
involved, if any, and (iv) the remedy sought. The arbitration shall be held at a
neutral place mutually agreeable to the parties. Within thirty (30) days of the
date of the Arbitration Notice, each party shall select one (1) Arbitrator, who
shall not be a current or former employee, agent, consultant or other
representative of either party; the two selected Arbitrators shall appoint a
third, neutral, Arbitrator.

The arbitration award shall be final and binding. Either party may enter any
such award in a court of the State of New Jersey having jurisdiction or may make
application to such court for judicial acceptance of the award and an order of
enforcement, as the case may be.

(d)               Currency

All references to money in the Agreement refer to U.S. dollars and all payments
made under this Agreement shall be in that currency.


                                      E-96


<PAGE>   12

(e)               Partial Invalidity

If any provision of this Agreement be held invalid, illegal or unenforceable,
such invalidity, illegality or unenforceability shall not affect any other
provision of this Agreement and the Parties shall use reasonable efforts to
substitute a valid, legal and enforceable provision which, as far as
practicable, implements the purposes and intent of the provision held invalid,
illegal or unenforceable. If the Parties are unable to arrive at such a
substitute, this Agreement shall be construed as if such invalid, illegal or
unenforceable provision had never been contained in it, provided that the
performance required under this Agreement with such a provision deleted remains
substantially consistent with the intent of the Parties.

(f)               Waiver

Failure to require performance of any provision of this Agreement does not waive
a Party's right to demand compliance with that provision at a later time. Waiver
of any default shall not waive any other default.

(g)               Entire Agreement

This Agreement contains the entire agreement between the Parties with respect to
the subject matter covered by this Agreement. No representations, whether oral
or written, made before this Agreement is executed shall amend this Agreement.
Any modification or amendment to this Agreement shall be in writing and signed
by an authorized officer of each Party.

(h)               Inurement

This Agreement shall be binding upon and shall inure to the benefit of the
Company and the Executive and their respective heirs, successors, assigns,
permitted receivers and legal representatives.

(i)               Language

The Company and the Executive have expressly requested that this Agreement and
any agreement, proceedings or documents thereto or referred to therein be
drafted and executed in the English language. Nymox et le Consultant ont
expressement exige que ce contrat ainsi que tous contrats, procedures ou
documents s'y rapportant ou qui y sont mentionnes soient rediges et signe en
langue anglaise.

IN WITNESS THEREOF, the undersigned have executed this Agreement as of the dates
set forth below:

ACCEPTED AND AGREED TO:
Nymox Pharmaceutical Corporation                     The Executive

/s/ Paul Averback                                    /s/ Judith Fitzpatrick
- --------------------------------                     ---------------------------
Paul Averback                                        Judith Fitzpatrick
President


                                      E-97



<PAGE>   1


EXHIBIT 23.1

                                      KPMG
                            2000 McGill College Ave.
                                   Suite 1900
                              Montreal, QC, Canada
                                    H3A 3H8

The Board of Directors
NYMOX PHARMACEUTICAL CORPORATION
9900 Cavendish Blvd.
Suite 306
Saint-Laurent  QC  H4M 2V2

We consent to the use of our reports included herein and to the reference to our
firm under the heading "Experts" in the prospectus.

KPMG
Chartered Accountants

Montreal, Canada
February 25, 2000


                                      E-85



<PAGE>   1

EXHIBIT 24.0

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below
under the heading "Signatures" constitutes and appoints Paul Averback and Roy
Wolvin, or either of them with full power to each to act alone, his true and
lawful attorneys-in-fact and agents with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities to sign any or all amendments to this registration statement, and to
file the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said
attorneys-in-fact and agents full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as fully for all intents and purposes as he might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents or their substitute or substitutes, may lawfully do or cause to be done
by virtue hereof.

Pursuant to the requirements of the Securities Act, this registration statement
has been signed by the following persons in the capacities and on the dates
indicated.

<TABLE>
<CAPTION>
Signature                                Title                              Date
- ---------                                -----                              ----
<S>                                      <C>                                <C>
/s/ W. David Angus                       Chairman and Director
- ---------------------------------
W. David Angus, QC

/s/ Paul Averback                        President and CEO
- ---------------------------------
Paul Averback, M.D.

/s/ Colin Bier                           Director
- ---------------------------------
Colin Bier, Ph.D.

/s/ Hans Black                           Director
- ---------------------------------
Hans Black, M.D.

/s/ Martin Barnes                        Director
- ---------------------------------
Martin Barnes

/s/ J. Kenneth Harrington                Director
- ---------------------------------
J. Kenneth Harrington, Ph.D.
</TABLE>

Nymox Corporation
(Authorized Representative in the United States)

By:  /s/ Roy Wolvin
     ----------------------------
     Roy Wolvin
     Secretary-Treasurer


                                      E-98



<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THE SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONSOLIDATED FINANCIAL STATEMENTS OF NYMOX PHARMACEUTICAL CORPORATION AS OF AND
FOR THE NINE MONTHS ENDED SEPTEMBER 30, 1999 AND IS QUALIFIED IN ITS ENTIRETY BY
REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>

<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-1999
<PERIOD-START>                             JAN-01-1999
<PERIOD-END>                               SEP-30-1999
<CASH>                                         925,765
<SECURITIES>                                         0
<RECEIVABLES>                                   60,822
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                             1,855,966
<PP&E>                                       1,891,640
<DEPRECIATION>                                 280,868
<TOTAL-ASSETS>                               3,466,738
<CURRENT-LIABILITIES>                          275,667
<BONDS>                                              0
                                0
                                          0
<COMMON>                                    24,410,480
<OTHER-SE>                                (21,219,409)
<TOTAL-LIABILITY-AND-EQUITY>                 3,191,071
<SALES>                                        178,496
<TOTAL-REVENUES>                               220,912
<CGS>                                                0
<TOTAL-COSTS>                                  252,977
<OTHER-EXPENSES>                             3,514,372
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                            (3,767,349)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                                  0
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                 67,379
<CHANGES>                                            0
<NET-INCOME>                               (3,479,058)
<EPS-BASIC>                                     (0.17)
<EPS-DILUTED>                                   (0.16)


</TABLE>

<PAGE>   1

EXHIBIT 99.0

CONTACT:                            -OR-             NYMOX's INVESTOR RELATIONS
COUNSEL
Nymox Corporation                                    The Equity Group Inc.
Michael Munzar, M.D.                                 www.theequitygroup.com
Medical Director                                     Devin Sullivan
(800) 93NYMOX                                        (212) 836-9608

                             FOR IMMEDIATE RELEASE

                NYMOX RAISES $12 MILLION IN FINANCING COMMITMENT

Kensington, MD - November 12, 1999 - NYMOX PHARMACEUTICAL CORP. (NASDAQ:NYMX)
today announced that it has secured U.S. $12.0 million in new equity financing.
The common stock equity line financing was placed privately with institutional
investors by Ladenburg Thalmann & Co. in New York.

"This financing reinforces Nymox's business objectives and will allow the
Company to accelerate its exciting developments in drugs and diagnostics," said
Paul Averback, President and CEO of Nymox. "We are very pleased to be working
with Ladenburg Thalmann & Co. and believe that the terms of this financing will
provide maximal value to our shareholders. We now have the additional resources
needed to realize more fully the value and potential of our technologies."

Nymox Pharmaceutical Corp. pioneers in the research and development of products
for the diagnosis and treatment of Alzheimer's Disease, an affliction for more
than 20 million people around the world. Nymox offers the world's only accurate,
non-invasive test to aid in the diagnosis of the disease, and is developing
proprietary Spheron-based drug therapies that could lead to effective treatment
of Alzheimer's Disease. Nymox also is developing unique drug therapies to treat
E. COLI infections and urinary tract infections, which have become highly
resistant to conventional antibiotic treatments. Nymox Pharmaceutical Corp. is
headquartered in Montreal, with a facility in Kensington, MD. Its stock is
traded on NASDAQ with the symbol NYMX. More information is available at
http://www.nymox.com

This press release contains certain "forward-looking statements," as defined in
the United States Private Securities Litigation Reform Act of 1995, that involve
a number of risks and uncertainties. There can be no assurance that such
statements will prove to be accurate and the actual results and future events
could differ materially from management's current expectations. Such factors are
detailed from time to time in the Company's filings with the United States
Securities and Exchange Commission and other regulatory authorities.


                                      E-99


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