ARQULE INC
SC 13G, 1997-02-14
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                                 (RULE 13D-102)

             INFORMATION STATEMENT PURSUANT TO RULES 13D-1 AND 13D-2
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                          (AMENDMENT NO. ___________)*

                                  ARQULE, INC.

                                (Name of Issuer)

                                     COMMON

                         (Title of Class of Securities)

                                   042 69E 107

                                 (CUSIP Number)



            *The  remainder  of  this  cover  page  shall  be  filled  out for a
reporting person's initial filing on this form with respect to the subject class
of securities,  and for any subsequent  amendment  containing  information which
would alter the disclosures provided in a prior cover page.

            The  information  required in the remainder of this cover page shall
not be deemed to be "filed"  for the  purpose  of  Section 18 of the  Securities
Exchange Act of 1934 or otherwise  subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  SEE
the NOTES).


                               Page 1 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  2  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Sevin Rosen Fund IV L.P.
        75-2416757
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                                (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        Delaware
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         810,174
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          4,295,500
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        810,174
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    4,295,500
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        PN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 2 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  3  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        SRB Associates IV L.P.
        75-2416758
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                 (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        Delaware
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         810,174
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          4,295,500
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH  -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    4,295,500
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|


- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        PN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 3 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  4  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Jon W. Bayless
        ###-##-####
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [   ]
                                                               (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        U.S.
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
NUMBER OF           0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        IN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 4 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  5  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Stephen M. Dow
        ###-##-####
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                                (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        U.S.
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        IN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 5 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  6  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Dennis J. Gorman
        ###-##-####
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                 (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        U.S.
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        IN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 6 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  7  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        John V. Jaggers
        ###-##-####
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                 (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        U.S.
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        IN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 7 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  8  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Charles H. Phipps
        ###-##-####
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                 (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        U.S.
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0 
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674

- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        IN
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 8 of 18 Pages

<PAGE>


- ----------------------------------           ----------------------------------
CUSIP NO. 042 69E 107                 13G        PAGE  9  OF  18  PAGES
- -----------------------------------          ----------------------------------


- -------------------------------------------------------------------------------
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

        Sevin Rosen Bayless Management Company
        75-2185911
- -------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                                (b)  [   ]

- -------------------------------------------------------------------------------
3       SEC USE ONLY

- -------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

        Texas
- -------------------------------------------------------------------------------

              5     SOLE VOTING POWER
  NUMBER OF         0
   SHARES     -----------------------------------------------------------------
BENEFICIALLY  6     SHARED VOTING POWER
  OWNED BY          5,105,674
    EACH      -----------------------------------------------------------------
  REPORTING   7     SOLE DISPOSITIVE POWER
 PERSON WITH        0
              -----------------------------------------------------------------
              8     SHARED DISPOSITIVE POWER
                    5,105,674
- -------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        5,105,674
- -------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                 |_|

- -------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        53.88%
- -------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*

        CO
- -------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



                               Page 9 of 18 Pages

<PAGE>



Item 1.
            (a)  NAME OF ISSUER.

            ArQule, Inc., a Delaware corporation (the "Issuer").

            (b)  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES.

            The Issuer's  principal  executive offices are located at 200 Boston
Avenue, Medford, Massachusetts 02155.

ITEM 2.

            (a) NAMES OF PERSONS FILING.

            This statement is filed by the following persons: (i) Sevin Rosen
Fund IV L.P. ("SR IV");  (ii) SRB  Associates IV L.P.  ("SRB IV");  (iii) Jon W.
Bayless  ("Bayless");  (iv)  Stephen  M.  Dow  ("Dow");  (v)  Dennis  J.  Gorman
("Gorman"); (vi) John V. Jaggers ("Jaggers"); (vii) Charles H. Phipps ("Phipps")
and (viii) Sevin Rosen Bayless Management Company ("Management Company").

            SRB IV is  the  general  partner  of SR IV.  Bayless,  Dow,  Gorman,
Jaggers  and Phipps  are the  general  partners  of SRB IV and are  officers  of
Management  Company.  In addition,  Bayless is a holder of certain shares of the
Management Company's issued and outstanding capital stock.

            (b)  ADDRESS OF PRINCIPAL BUSINESS OFFICE.

            The  principal  business  office of each of SR IV, SRB IV,  Bayless,
Gorman, Jaggers, Phipps and Management Company is Two Galleria Tower, 13455 Noel
Road, Suite 1670,  Dallas,  Texas 75240. The principal business office of Dow is
550 Lytton Avenue, Suite 200, Palo Alto, California 94301.


                               Page 10 of 18 Pages

<PAGE>



            (c)  CITIZENSHIP.

            SR IV and SRB IV are each Delaware limited partnerships. Bayless,
Dow, Gorman, Jaggers and Phipps are each U.S. citizens.  Management Company is a
Texas corporation.

            (d) TITLE OF CLASS OF SECURITIES.

            This statement relates to shares of Common Stock, par value $.01 per
share (the "Common Stock"), of the Issuer.

            (e)  CUSIP NUMBER.

            042 69E 107

ITEM 3.

            This  statement  is not  being  filed  pursuant  to Rule  13d-1(b)
or 13d-2(b).

ITEM 4.     OWNERSHIP.1

            (a)  AMOUNT BENEFICIALLY OWNED.

               (i)  SR IV beneficially  owns 5,105,674 shares of Issuer's Common
                    Stock.

               (ii) SRB IV beneficially owns 5,105,674 shares of Issuer's Common
                    Stock.

               (iii)Each  of  Bayless,   Gorman,   Jaggers,   Dow,   Phipps  and
                    Management  Company  beneficially  owns 5,105,674  shares of
                    Issuer's Common Stock.

- --------------------

1    Of the 5,105,674 shares of Issuer's Common Stock beneficially owned by each
     of SR IV, SRB IV,  Bayless,  Gorman,  Jaggers,  Dow,  Phipps and Management
     Company,  810,174 shares are owned of record by SR IV and 4,295,500  shares
     are owned of record by a partnership  ("ArQule  Partners L.P."). SR IV is a
     limited partner or ArQule Partners L.P. and is the owner of a majority 
     interest in a corporate general partner of ArQule Partners L.P.


                               Page 11 of 18 Pages

<PAGE>




            (b)  PERCENT OF CLASS.2

                  (i)   SR IV -- 53.88%.

                  (ii)  SRB IV -- 53.88%.

                  (iii) Each of Bayless, Dow, Gorman, Jaggers, Phipps and
                        Management Company -- 53.88%.

            (c)  POWER TO VOTE OR DIRECT THE VOTE AND DISPOSE OR DIRECT THE
DISPOSITION OF SECURITIES.

                  (i)   Each  of SR IV and  SRB IV has  sole  power  to  vote or
                        dispose  or to  direct  the vote or  disposition  of the
                        shares of Issuer's Common Stock.

                  (ii)  Each  of  Bayless,  Dow,  Gorman,  Jaggers,  Phipps  and
                        Management  Company has shared  power to vote or dispose
                        or to direct  the vote or  disposition  of the shares of
                        Issuer's Common Stock.

ITEM 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

            If this  statement  is being filed to report the fact that as of the
            date  hereof the  reporting  person has ceased to be the  beneficial
            owner of more than five  percent of the class of  securities,  check
            the following [ ]

ITEM 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

            ArQule L.P. is the record holder  4,295,500  shares of Issuer's
            Common Stock.  The general  partners of ArQule L.P. have delegated
            their respective  voting and  investment  authority with respect to
            the shares of Issuer's Common Stock owned of record by ArQule L.P.
            to n  Investment  Committee.  Dow is a  member  of  the  Investment
            Committee.

- -----------------

2    According to the most recently  available  filing with the  Securities  and
     Exchange Commission in which such number is required to be indicated.


                               Page 12 of 18 Pages

<PAGE>



ITEM 7.     IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
            THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

            Not applicable.

ITEM 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

            Not applicable.

ITEM 9.     NOTICE OF DISSOLUTION OF GROUP.

            Not applicable.

ITEM 10.    CERTIFICATION.

            Not applicable.



                               Page 13 of 18 Pages

<PAGE>



                        SIGNATURE/SIGNED IN COUNTERPART

            After reasonable inquiry and to the best knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
statement is true, complete and correct.

                                    SEVIN ROSEN FUND IV L.P.

                                    By: SRB Associates IV L.P.,
                                         General Partner


Dated:  February 13, 1997           By:/S/ JOHN V. JAGGERS
                                       --------------------------------------
                                       John V. Jaggers, a General Partner


                                    SRB ASSOCIATES IV L.P.


Dated:  February 13, 1997           By: /S/ JOHN V. JAGGERS
                                        -------------------------------------
                                        John V. Jaggers, a General Partner



Dated:  February 13, 1997                /S/ JON W. BAYLESS
                                         ------------------------------------
                                         Jon W. Bayless


Dated:  February 13, 1997                /S/ JOHN V. JAGGERS, ATTORNEY-IN-FACT
                                         ------------------------------------
                                         Stephen M. Dow


Dated:  February 13, 1997                /S/ DENNIS J. GORMAN
                                         ------------------------------------
                                         Dennis J. Gorman


Dated:  February 13, 1997                /S/ JOHN V. JAGGERS
                                         ------------------------------------
                                         John V. Jaggers


Dated:  February 13, 1997                /S/ CHARLES H. PHIPPS
                                         ------------------------------------
                                         Charles H. Phipps

                                    SEVIN ROSEN BAYLESS MANAGEMENT COMPANY


Dated:  February __, 1997           By:  /S/ JOHN V. JAGGERS
                                       --------------------------------------
                                         Title:  Vice President


                               Page 14 of 18 Pages

<PAGE>



                                 EXHIBIT INDEX

            EXHIBIT


1.          Joint Filing Agreement.

2.          Power of Attorney.


                               Page 15 of 18 Pages

<PAGE>



                                   EXHIBIT 1

                 THIS DOCUMENT HAS BEEN SIGNED IN COUNTERPART

                            JOINT FILING AGREEMENT


            In accordance  with Rule 13d-1(f) under the Securities  Exchange Act
of 1934,  the persons named below agree to the joint filing on behalf of each of
them of a Statement on Schedule 13G (including  amendments thereto) with respect
to the common stock of ArQule,  Inc.,  and further  agree that this Joint Filing
Agreement be included as an Exhibit to such joint filings.  In evidence  thereof
each of the undersigned, being duly authorized, hereby execute this Agreement on
the date set forth opposite its or his name.

                                    SEVIN ROSEN FUND IV L.P.

                                    By: SRB ASSOCIATES IV L.P.,
                                         General Partner



Dated:  February 13, 1997                By:/S/ JOHN V. JAGGERS
                                            ----------------------------------
                                            John V. Jaggers, a General Partner


                                    SRB ASSOCIATES IV L.P.



Dated:  February 13, 1997           By: /S/ JOHN V. JAGGERS
                                        --------------------------------------
                                        John V. Jaggers, a General Partner



Dated:  February 13, 1997                /S/ JON W. BAYLESS
                                         -------------------------------------
                                         Jon W. Bayless



Dated:  February 13, 1997                /S/ JOHN V. JAGGERS, ATTORNEY-IN-FACT
                                         -------------------------------------
                                         Stephen M. Dow





                               Page 16 of 18 Pages

<PAGE>



Dated:  February 13, 1997                /S/ DENNIS J. GORMAN
                                         -------------------------------------
                                         Dennis J. Gorman



Dated:  February 13, 1997                /S/ JOHN V. JAGGERS
                                         -------------------------------------
                                         John V. Jaggers



Dated:  February 13, 1997                /S/ CHARLES H. PHIPPS
                                         -------------------------------------
                                         Charles H. Phipps



                                    SEVIN ROSEN BAYLESS MANAGEMENT COMPANY



Dated:  February 13, 1997           By:  /S/ JOHN V. JAGGERS
                                       ---------------------------------
                                         Title:  Vice President




                               Page 17 of 18 Pages

<PAGE>


                                   EXHIBIT 2

                               POWER OF ATTORNEY

            The  undersigned,  STEPHEN M. DOW,  hereby  makes,  constitutes  and
appoints each of DENNIS J. GORMAN, JOHN V. JAGGERS AND JON W. BAYLESS,  and each
of them singly, his true and lawful  attorney-in-fact and agent, with full power
to them, and each of them singly,  and with full power of substitution,  to sign
for the  undersigned  and in his  name,  any Form  144,  Form 3, Form 4, Form 5,
Schedule 13D and Schedule 13G, and any and all amendments  thereto,  and to file
the same, and all exhibits thereto,  and all documents in connection  therewith,
with the Securities and Exchange  Commission,  and generally to do all things in
the name of the  undersigned  and on his  behalf to enable  the  undersigned  to
comply  with the  reporting  requirements  of the  Securities  Act of  1933,  as
amended,  and  the  Securities  Exchange  Act  of  1934,  as  amended,  and  all
requirements of the Securities and Exchange Commission.

            This  Power of  Attorney  shall not be  affected  by the  subsequent
disability or incompetence of the undersigned.

            This Power of Attorney may not be changed orally.

            The undersigned  hereby agrees that any third party receiving a duly
executed  copy or  reproduction  of this  Power of  Attorney  may act  under it.
Revocation or termination of this Power of Attorney will not be effective  until
the third party receives actual knowledge of the termination or revocation.  The
undersigned shall hold harmless any third party from and against any claims that
may arise  against  the third  party as a result of  reliance  on this  Power of
Attorney.

            IN WITNESS  WHEREOF,  the  undersigned  has  executed  this Power of
Attorney as of the 13th day of June, 1994.


                                                /s/  Stephen M. Dow
                                                ------------------------------
                                                     Stephen M. Dow

STATE OF TEXAS          )
                        )ss.:
COUNTY OF DALLAS        )

            On this 13th day of June,  1994 before me personally came Stephen M.
Dow,  to me known and known to me to be the  individual  described  in,  and who
executed the foregoing  instrument,  and he  acknowledged to me that he executed
the same.


                                             /s/ Jo Anne Eisler
                                             ---------------------------------
                                                 Notary Public
My commission expires:  May 27, 1998


                               Page 18 of 18 Pages



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