ARQULE INC
4, 1998-03-10
PHARMACEUTICAL PREPARATIONS
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 4
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
( ) Check this box if no longer subject to Section 16.
Form 4 or Form 5 obligations may continue. See Instructions 1(b).
1. Name and Address of Reporting Person
   Dow, Stephen M.
   c/o Sevin Rosen Fund IV L.P.
   Two Galleria Tower
   13455 Noel Road, Suite 1670
   Dallas, TX  75240
2. Issuer Name and Ticker or Trading Symbol
   ArQule, Inc.
   ('ARQL")
3. IRS or Social Security Number of Reporting Person (Voluntary)
   
4. Statement for Month/Year
   February 1998
5. If Amendment, Date of Original (Month/Year)
   
6. Relationship of Reporting Person(s) to Issuer (Check all applicable)
   (X) Director ( ) 10% Owner ( ) Officer (give title below) ( ) Other
   (specify below)
   
7. Individual or Joint/Group Filing (Check Applicable Line)
   (X) Form filed by One Reporting Person
   ( ) Form filed by More than One Reporting Person
<TABLE>
<CAPTION>
___________________________________________________________________________________________________________________________________
 Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned                                                 |
___________________________________________________________________________________________________________________________________|
1. Title of Security       |2.    |3.    |4.Securities Acquired (A)         |5.Amount of        |6.Dir |7.Nature of Indirect       |
                           | Transaction |  or Disposed of (D)              |  Securities       |ect   |  Beneficial Ownership     |
                           |      |      |                                  |  Beneficially     |(D)or |                           |
                           |      |    | |                  | A/|           |  Owned at         |Indir |                           |
                           | Date |Code|V|    Amount        | D |    Price  |  End of Month     |ect(I)|                           |
___________________________________________________________________________________________________________________________________|
<S>                        <C>    <C>  <C><C>               <C> <C>         <C>                 <C>    <C>
Common Stock, par value $.0|      |    | |                  |   |           |658,113            |I     |By Sevin Rosen Fund IV L.P.|
1 per share                |      |    | |                  |   |           |                   |      | (1)                       |
- -----------------------------------------------------------------------------------------------------------------------------------|
Common Stock, par value $.0|      |    | |                  |   |           |58,314             |I     |By The Dow Family Trust (2)|
1 per share                |      |    | |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
Common Stock, par value $.0| 02/26|   S| |           24,421 | D |    $23.375|-0-                |I     |By Legomer Investors, Inc. |
1 per share                |/98   |    | |                  |   |           |                   |      |(3)                        |
- -----------------------------------------------------------------------------------------------------------------------------------|
___________________________________________________________________________________________________________________________________|
<CAPTION>
___________________________________________________________________________________________________________________________________
 Table II -- Derivative Securitites Acquired, Disposed of, or Beneficially Owned                                                   |
___________________________________________________________________________________________________________________________________|
1.Title of Derivative |2.Con-  |3.   |4.    |5.Number of De |6.Date Exer|7.Title and Amount  |8.Price|9.Number    |10.|11.Nature of|
  Security            |version |Transaction | rivative Secu |cisable and|  of Underlying     |of Deri|of Deriva   |Dir|Indirect    |
                      |or Exer |     |      | rities Acqui  |Expiration |  Securities        |vative |tive        |ect|Beneficial  |
                      |cise    |     |      | red(A) or Dis |Date(Month/|                    |Secu   |Securities  |(D)|Ownership   |
                      |Price of|     |      | posed of(D)   |Day/Year)  |                    |rity   |Benefi      |or |            |
                      |Deriva- |     |      |               |Date |Expir|                    |       |ficially    |Ind|            |
                      |tive    |     |      |           | A/|Exer-|ation|   Title and Number |       |Owned at    |ire|            |
                      |Secu-   |     |    | |           | D |cisa-|Date |   of Shares        |       |End of      |ct |            |
                      |rity    |Date |Code|V|  Amount   |   |ble  |     |                    |       |Month       |(I)|            |
___________________________________________________________________________________________________________________________________|
<S>                   <C>      <C>   <C>  <C><C>        <C> <C>   <C>   <C>          <C>     <C>     <C>          <C> <C>
Stock Option (Right to|$11.00  |     |    | |           |   |(4)  |08/14|Common Stock|7,500  |       |7,500       |D  |            |
 Buy)                 |        |     |    | |           |   |     |/06  |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option (Right to|$17.625 |     |    | |           |   |immed|05/14|Common Stock|3,500  |       |3,500       |D  |            |
 Buy)                 |        |     |    | |           |   |.    |/07  |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
                      |        |     |    | |           |   |     |     |            |       |       |            |   |            |
___________________________________________________________________________________________________________________________________|
</TABLE>
Explanation of Responses:
(1)  The Reporting Person is a general partner of SRB Associates IV L.P., the 
general partner of Sevin Rosen Fund 
IV L.P.  The Reporting Person disclaims beneficial ownership, within the 
meaning of Rule 13d-3 under the Securities 
Exchange Act of 1934, as amended (the "Exchange Act"), of the shares of stock 
held by such entities except to the 
extent of his proportionate partnership interest 
therein.
(2)  The Reporting Person and his spouse are the trustees of The Dow Family 
Trust and the beneficiaries of such 
trust are the Reporting Person and members of his immediate 
family.
(3)  Sevin Rosen Fund IV L.P. is a majority stockholder in Legomer Investors, 
Inc.  The Reporting Person is the 
President and a director of Legomer Investors, Inc.  The Reporting Person 
disclaims beneficial ownership, within the 
meaning of Rule 13d-3 under the Exchange Act, of the shares of stock owned by 
Legomer Investors, Inc., except 
to the extent of his pecuniary interest 
therein.
(4)  This option is currently vested and exercisable with respect to 2,500 
shares of stock covered thereby and will 
become exercisable at the rate of 2,500 shares on the date of each of the 1998 
and 1999 annual meetings of 
stockholders of the 
Issuer.
SIGNATURE OF REPORTING PERSON
/s/ John V. Jaggers, as Attorney-in-Fact
DATE
March  10, 1998



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