ARQULE INC
SC 13G/A, 1998-02-17
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                                 (RULE 13d-102)

                           INFORMATION TO BE INCLUDED
                         IN STATEMENTS FILED PURSUANT TO
                      RULES 13D-1(b) AND (c) AND AMENDMENTS
                         THERETO FILED PURSUANT TO 13d-2

                               (AMENDMENT NO. 1)*

                                  ARQULE, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                     COMMON
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   042 69E 107
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                             ----------------------

            *The  remainder  of  this  cover  page  shall  be  filled  out for a
reporting person's initial filing on this form with respect to the subject class
of securities,  and for any subsequent  amendment  containing  information which
would alter the disclosures provided in a prior cover page.

            The  information  required in the remainder of this cover page shall
not be deemed to be "filed"  for the  purpose  of  Section 18 of the  Securities
Exchange Act of 1934 or otherwise  subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  SEE
the NOTES).


                               Page 1 of 5 Pages
<PAGE>



- --------------------------------------------------------------------------------
CUSIP  042 692 107                    13G             Page  2 of  5 Pages
- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       Sevin Rosen Bayless Management Company
- -------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a) [   ]
                                                                 (b) [   ]


- --------------------------------------------------------------------------------
3      SEC USE ONLY


- --------------------------------------------------------------------------------
4      CITIZENSHIP OR PLACE OF ORGANIZATION

       Texas
- --------------------------------------------------------------------------------
                   
  NUMBER OF SHARES       5     SOLE VOTING POWER
BENEFICIALLY OWNED             -0-
 BY EACH REPORTING
   PERSON WITH           -------------------------------------------------------
                         6     SHARED VOTING POWER
                               -0-
                         -------------------------------------------------------
                         7     SOLE DISPOSITIVE POWER
                               -0-
                         -------------------------------------------------------
                         8     SHARED DISPOSITIVE POWER
                               -0-
- --------------------------------------------------------------------------------
9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       -0-
- --------------------------------------------------------------------------------
10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
       CERTAIN SHARES*                           :


- --------------------------------------------------------------------------------
11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


       0.0%
- --------------------------------------------------------------------------------
12     TYPE OF REPORTING PERSON*


       CO
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>



ITEM 1.

            (A)  NAME OF ISSUER.

            ArQule, Inc., a Delaware corporation (the "Issuer").

            (B)  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES.

            The Issuer's principal executive offices are located at 200
Boston Avenue, Medford, Massachusetts  02155.

ITEM 2.

            (A) NAMES OF PERSONS FILING.

            This  statement is filed by Sevin Rosen Bayless  Management  Company
("Management Company").

            (B)  ADDRESS OF PRINCIPAL BUSINESS OFFICE.

            The principal business office of  Management Company is  13455  Noel
Road, Suite 1670, Dallas, Texas 75240.

            (C)  CITIZENSHIP.

            Management Company is a Texas corporation.

            (D) TITLE OF CLASS OF SECURITIES.

            This statement relates to shares of Common Stock, par value $.01 per
share (the "Common Stock"), of the Issuer.

            (E)  CUSIP NUMBER.

            042 69E 107

ITEM 3.

            This  statement  is not being  filed  pursuant  to Rule  13d-1(b) or
13d-2(b).


                                  Page 3 of 5 Pages
<PAGE>


ITEM 4.     OWNERSHIP.

            (A)  AMOUNT BENEFICIALLY OWNED.

            Management  Company  beneficially  owns  Zero (0)  shares  of Common
                        Stock.

            (B)  PERCENT OF CLASS.

                  0.0%

            (C)  POWER TO VOTE OR DIRECT  THE VOTE AND  DISPOSE  OR  DIRECT  THE
            DISPOSITION OF SECURITIES.

            Management  Company  has  neither  sole  nor shared power to vote or
            dispose or to direct the vote or disposition of any shares of Common
            Stock.

ITEM        5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

            If this statement is being filed to report  the  fact that as of the
            date  hereof  the  reporting  person has ceased to be the beneficial
            owner of more than five percent of the class  of  securities,  check
            the following [ X ]

ITEM 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

            Not Applicable.

ITEM 7.     IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY  WHICH  ACQUIRED
            THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

            Not applicable.

ITEM 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

            Not applicable.

ITEM 9.     NOTICE OF DISSOLUTION OF GROUP.

            Not applicable.

ITEM 10.    CERTIFICATION.

            Not applicable.



                               Page 4 of 5 Pages
<PAGE>


                                   SIGNATURES

            After reasonable inquiry and to the best knowledge and belief of the
undersigned,  the  undersigned  certifies that the information set forth in this
statement is true, complete and correct.

                                    SEVIN ROSEN BAYLESS
                                            MANAGEMENT COMPANY




Dated:  February 13, 1998           By: /s/ John Jaggers
                                        ----------------------------------------
                                        John V. Jaggers
                                        Title: Vice President

















                               Page 5 of 5 Pages


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