ARQULE INC
S-8, 1999-07-01
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
      As filed with the Securities and Exchange Commission on July 1, 1999

                                                     REGISTRATION NO. 333-[    ]


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D. C. 20549


                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933


                                  ARQULE, INC.
             (Exact name of registrant as specified in its charter)
<TABLE>
<CAPTION>
<S>                                                                                             <C>
                   DELAWARE                                                                                  04-3221586
(State or other jurisdiction of incorporation)                                                  (I.R.S. Employer Identification No.)

  200 BOSTON AVENUE, MEDFORD, MASSACHUSETTS                                                                    02155
   (Address of Principal Executive Offices)                                                                  (Zip Code)

</TABLE>


                        1996 EMPLOYEE STOCK PURCHASE PLAN
                            (Full Title of the Plan)

                                 STEPHEN A. HILL
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                  ArQule, Inc.
                                200 Boston Avenue
                                Medford, MA 02155
                     (Name and Address of Agent For Service)

                                 (781) 395-4100
                     (Telephone Number, Including Area Code
                              of Agent For Service)

                                 With copies to:

                                 Michael Lytton
                               Palmer & Dodge LLP
                                One Beacon Street
                                Boston, MA 02108
                                 (617) 573-0100



                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
- ----------------------------------- -------------------- -------------------- --------------------- ------------------

<S>                                    <C>               <C>                   <C>                  <C>
    Title Of Securities To Be          Amount To Be       Proposed Maximum      Proposed Maximum        Amount Of
            Registered                  Registered       Offering Price Per    Aggregate Offering   Registration Fee
                                                              Share(1)              Price(1)
- ----------------------------------- -------------------- -------------------- --------------------- ------------------

Common Stock, $0.01 par value            300,000(2)           $4.34375             $1,303,125            $362.29
- ----------------------------------- -------------------- -------------------- --------------------- ------------------
</TABLE>
(1)      Estimated solely for the purpose of determining the registration fee
         and computed pursuant to Rule 457(h) based upon the average of the high
         and low sale prices on June 24, 1999 as reported by the Nasdaq National
         Market.
(2)      This Registration Statement registers an additional 300,000 shares
         under the 1996 Employee Stock Purchase Plan, under which 120,000 shares
         have been previously registered (SEC File No. 333-19469).




                                       1
<PAGE>   2





                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

STATEMENT REGARDING INCORPORATION BY REFERENCE OF INFORMATION FROM EFFECTIVE
REGISTRATION STATEMENT

This Registration Statement registers additional securities of the same class as
other securities for which a registration statement filed on Form S-8 relating
to the 1996 Employee Stock Purchase Plan is already effective. Pursuant to
General Instruction E of this Form, the Registrant incorporates by reference
into this Registration Statement the contents of the Registrant's Registration
Statement on Form S-8 (Registration No. 333-19469) as filed with the Commission
on January 9, 1997, including exhibits thereto.


ITEM 8. EXHIBITS.

         The Exhibit Index immediately preceding the exhibits is incorporated
herein by reference.




                                       2
<PAGE>   3



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Medford, Massachusetts, on this 1st day of July,
1999.

                                      ARQULE, INC.


                                      By:  /s/ Stephen A Hill
                                         ---------------------------------------
                                           Stephen A. Hill
                                           President and Chief Executive Officer




                                       3
<PAGE>   4



                                POWER OF ATTORNEY


         We, the undersigned officers and directors of ArQule, Inc. hereby
severally constitute and appoint Stephen A. Hill, James R. Fitzgerald, Jr.,
Michael Lytton and Lynnette C. Fallon, and each of them singly, our true and
lawful attorneys-in-fact, with full power to them in any and all capacities, to
sign any and all amendments to this Registration Statement on Form S-8 including
any post-effective amendments thereto, and to file the same, with exhibits
thereto and other documents in connection therewith, with the Securities and
Exchange Commission, hereby ratifying and confirming all that each of said
attorneys-in-fact may do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated:

         SIGNATURE                        TITLE                        DATE
         ---------                        -----                        ----

/s/ Stephen A Hill              President, Chief Executive          July 1, 1999
- ---------------------------     Officer and Director
Stephen A. Hill                 (Principal Executive
                                Officer)



/s/ Joseph C. Hogan             Director, Chief Scientific          July 1, 1999
- ---------------------------     Officer, Chairman
Joseph C. Hogan, Jr.



/s/ James R. Fitzgerald Jr.     Vice President and Chief            July 1, 1999
- ---------------------------     Financial Officer (Principal
James R. Fitzgerald, Jr.        Financial Officer and Principal
                                Accounting Officer)



/s/ Stephen M. Dow              Director                            July 1, 1999
- ---------------------------
Stephen M. Dow


/s/ Allan R. Ferguson           Director                            July 1, 1999
- ---------------------------
Allan R. Ferguson


/s/ L. Patrick Gage             Director                            July 1, 1999
- ---------------------------
L. Patrick Gage


/s/ Michael Rosenblatt          Director                            July 1, 1999
- ---------------------------
Michael Rosenblatt



                                       4
<PAGE>   5


                                  EXHIBIT INDEX
                                  -------------

EXHIBIT NUMBER                          DESCRIPTION

     5.1           Opinion of Palmer & Dodge LLP as to the legality of the
                   securities registered hereunder.*

    23.1           Consent of PricewaterhouseCoopers LLP, independent
                   accountants.*

    23.2           Consent of Palmer & Dodge LLP (contained in Opinion of Palmer
                   & Dodge LLP, filed as Exhibit 5.1).

    24.1           Power of Attorney (set forth on the signature page to this
                   Registration Statement).




- ------------------------------------
*Filed herewith.










                                       5

<PAGE>   1


                                                                     EXHIBIT 5.1

                               PALMER & DODGE LLP
                                ONE BEACON STREET
                              BOSTON, MA 02108-3190



                                 June 30, 1999


ArQule, Inc.
200 Boston Avenue
Medford, Massachusetts 02155

         Re:  1996 Employee Stock Purchase Plan
              ---------------------------------

Ladies and Gentlemen:

         We are rendering this opinion in connection with the Registration
Statement on Form S-8 (the "Registration Statement") filed by ArQule, Inc. (the
"Company") with the Securities and Exchange Commission (the "Commission") under
the Securities Act of 1933, as amended (the "Act"), on or about the date hereof.
The Registration Statement relates to 300,000 shares (the "Shares") of the
Company's Common Stock, $0.01 par value, offered pursuant to the provisions of
the Company's 1996 Employee Stock Purchase Plan (the "Plan").

         We have examined the Amended and Restated Certificate of Incorporation
of the Company, the Amended and Restated By-laws of the Company, and originals,
or copies certified to our satisfaction, of all pertinent records of the actions
of the directors and stockholders of the Company, the Registration Statement and
such other documents relating to the Company as we have deemed material for the
purposes of this opinion.

         In examination of the foregoing documents, we have assumed the
genuineness of all signatures and the authenticity of all documents submitted to
us as originals, the conformity to original documents of all documents submitted
to us as certified or photostatic copies, and the authenticity of the originals
of such latter documents.

         Based on the foregoing, we are of the opinion that the Company has duly
authorized for issuance the shares of its Common Stock covered by the
Registration Statement to be issued under the Plan, as described in the
Registration Statement, and such shares, when issued in accordance with the
terms of the Plan, will be validly issued, fully paid and nonassessable.

         We hereby consent to the filing of this opinion as a part of the
Registration Statement.


                                Very truly yours,

                                /s/ Palmer & Dodge LLP

                                PALMER & DODGE LLP




<PAGE>   1


                                                                    EXHIBIT 23.1


                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in this Registration
Statement on Form S-8 of our report dated January 29, 1999, relating to the
financial statements which appears in ArQule, Inc.'s Annual Report on Form 10-K
for the year ended December 31, 1998.


PRICEWATERHOUSECOOPERS LLP
Boston, Massachusetts
June 30, 1999





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