ARQULE INC
RW, 2000-04-25
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

                                  ARQULE, INC.
                               19 PRESIDENTIAL WAY
                                WOBURN, MA 01801

                                 April 24, 2000


BY EDGAR
- --------

Securities and Exchange Commission
Division of Corporation Finance
450 Fifth Street, N.W.
Judiciary Plaza
Washington, D.C.  20549


     Re:  ArQule, Inc.
          Registration Statement on Form S-3 - Application for Withdrawal
          (Registration No. 333-33344)
          ----------------------------

Gentlemen and Ladies:

         In accordance with Rule 477 promulgated under the Securities Act of
1933, as amended, ArQule, Inc. (the "Company") hereby requests that the
Company's Registration Statement on Form S-3 (Registration No. 333-33344) (the
"Registration Statement"), and all exhibits thereto, be withdrawn effective
immediately. The Company is withdrawing the Registration Statement, which has
not been declared effective, because the proposed public offering under the
Registration Statement was abandoned due to market conditions. No securities
were sold or will be sold under the Registration Statement.

         The Company further requests that, pursuant to Rule 477(c), an order
with the date of the granting of the withdrawal be included in the file for the
above-captioned Registration Statement in the following manner: "Withdrawn upon
the request of the registrant, the Commission consenting thereto."

         If you have any questions with respect to this letter, please call
either Michael E. Lytton of the law firm Palmer & Dodge LLP at (617) 573-0327 or
me at (781) 994-0300.




                                        Sincerely,

                                        ARQULE, INC.



                                        By: /s/ David C. Hastings
                                            -----------------------------------
                                            David C. Hastings
                                            Vice President, Chief Financial
                                            Officer


cc: Sean Harrison
    Michael E. Lytton
    Jonathan L. Kravetz




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