ASCENT PEDIATRICS INC
SC 13D/A, 1999-03-02
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                                (Amendment No. 1)

                             ASCENT PEDIATRICS, INC.
                                (Name of Issuer)

                                  Common Stock,
                           $.00004 PAR VALUE PER SHARE
                         (Title of Class of Securities)

                                    04362X101
                                 (CUSIP Number)

                                Brian P. Friedman
                           FS Private Investments LLC
                         55 East 52nd Street, 37th Floor
                          New York, New York 10055-0002
                                 (212) 309-8348
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                FEBRUARY 16, 1999
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), Rule 13d-1(f) or Rule 13d-1(g), check the
following box [ ]

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  2
- -------------------------------                       --------------------------

- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     FS Private Investments LLC                                    13-3940684

- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       
 
                                                                   (a)  / / 
                                                                   (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF, OO
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/

- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,101,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.
    
                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,101,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,101,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    36.80%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    IA
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  3
- -------------------------------                       --------------------------

- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Furman Selz Investors II L.P.                                 13-3937561

- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    

                                                                    (a)  / /
                                                                    (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     WC
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  2,602,300, which includes
        EACH             974,316 shares of Common Stock issuable upon the
     REPORTING           conversion of $4,628,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.
    
                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  2,602,300, which includes
                         974,316 shares of Common Stock issuable upon the
                         conversion of $4,628,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    2,602,300
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                      /_/

- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    31.3%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON

    PN
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  4
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     FS Employee Investors LLC                                     13-3937563
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    

                                                                   (a) / /
                                                                   (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     WC
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  223,112, which includes
        EACH             83,579 shares of Common Stock issuable upon the
     REPORTING           conversion of $397,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  223,112, which includes
                         83,579 shares of Common Stock issuable upon the
                         conversion of $397,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    223,112
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    3.0%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    OO
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  5
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     FS Parallel Fund L.P.                                         13-3974766
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        

                                                                    (a)  / /
                                                                    (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     WC
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  126,569, which includes
        EACH             47,368 shares of Common Stock issuable upon the
     REPORTING           conversion of $225,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  126,569, which includes
                         47,368 shares of Common Stock issuable upon the
                         conversion of $225,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    126,569
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    1.7%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    PN
- --------------------------------------------------------------------------------

<PAGE>

                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  6
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Furman Selz Investments II LLC                                13-3937560
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    

                                                                 (a) / /
                                                                 (b) /x/
- -------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  2,951,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  2,951,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    2,951,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.0%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    IA
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  7
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     ING Baring Furman Selz LLC                                    13-3856626
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*               

                                                                  (a)  / /
                                                                  (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF and WC
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,001,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,001,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,001,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.6%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    OO
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  8
- -------------------------------                       --------------------------

- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     ING Groep N.V.
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        
                                                               (a) / /
                                                               (b) /x/

- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     The Netherlands
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,001,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,001,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,001,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.6%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    IC
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  9
- -------------------------------                       --------------------------

- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     ING Merger, Inc.                                              75-2085140
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*          

                                                             (a) / / 
                                                             (b) /x/

- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)
                                                                      /_/

- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,001,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,001,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,001,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.6%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    CO
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  10
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     ING (U.S.) Financial Holdings Corporation                     51-0262561

- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*          

                                                                    (a) / /
                                                                    (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,001,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,001,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,001,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.6%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    CO
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page 11
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     ING Bank N.V.                 
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         

                                                                  (a) / /
                                                                  (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*
 
     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     The Netherlands
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,001,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,001,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,001,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    35.6%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    BK
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  12
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Brian P. Friedman                                             ###-##-####
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    

                                                                (a) / /
                                                                (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,101,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,101,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,101,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    36.8%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    IN
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D

- -------------------------------                       --------------------------
CUSIP No. 04362 X1 01                                   Page  13
- -------------------------------                       --------------------------
- --------------------------------------------------------------------------------
 1   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     James L. Luikart                                              ###-##-####
- --------------------------------------------------------------------------------
 2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                
                           
                                                               (a) / /
                                                               (b) /x/
- --------------------------------------------------------------------------------
 3   SEC USE ONLY

- --------------------------------------------------------------------------------
 4   SOURCE OF FUNDS*

     AF
- --------------------------------------------------------------------------------
 5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) OR 2(e)

                                                                      /_/
- --------------------------------------------------------------------------------
 6   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States
- --------------------------------------------------------------------------------
       NUMBER OF     7   SOLE VOTING POWER
        SHARES
     BENEFICIALLY    -----------------------------------------------------------
       OWNED BY      8   SHARED VOTING POWER  3,101,981, which includes
        EACH             1,105,263 shares of Common Stock issuable upon the
     REPORTING           conversion of $5,250,000 aggregate principal amount of
     PERSON WITH         the Company's 8.0% Convertible Subordinated Notes.

                     -----------------------------------------------------------
                     9   SOLE DISPOSITIVE POWER
                     -----------------------------------------------------------
                    10   SHARED DISPOSITIVE POWER  3,101,981, which includes
                         1,105,263 shares of Common Stock issuable upon the
                         conversion of $5,250,000 aggregate principal amount of
                         the Company's 8.0% Convertible Subordinated Notes.
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,101,981
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      /_/
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    36.8%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*

    IN
- --------------------------------------------------------------------------------

<PAGE>
ITEM 1.   SECURITY AND ISSUER.

          The securities to which this statement relates are shares of common
stock, $0.00004 par value per share (the "Common Stock"), of Ascent Pediatrics,
Inc., a Delaware corporation ("Ascent" or the "Company"). The principal
executive office of Ascent is located at 187 Ballardvale Street, Wilmington,
Massachusetts 01887.

          The Reporting Persons are filing this Amendment No. 1 to Schedule 13D
because of an amendment, dated February 16, 1999, to the Securities Purchase
Agreement dated May 13, 1998 (the "Purchase Agreement") among the Company, and
the persons named as purchasers on Schedule I attached thereto (each a
"Purchaser" and collectively, the "Purchasers"). Pursuant to the Purchase
Agreement, certain of the Reporting Persons acquired shares of the Series G
Convertible Exchangeable Preferred Stock, $.01 par value per share (the
"Preferred Shares"), warrants to purchase shares of Common Stock (the
"Warrants") and 8% Subordinated Notes due 2005 of the Company (the "Subordinated
Notes"). The Preferred Shares are convertible into Common Stock and exchangeable
into convertible subordinated notes of the Company (the "Convertible Notes").

          Pursuant to an Amendment to the Purchase Agreement, certain of the
Reporting Persons agreed to purchase additional shares of Common Stock from the
Company (the "Direct Shares"), and to exercise all outstanding Warrants as of
the Second Amendment Closing Date (as defined in Item 4 below).

ITEM 2.   IDENTITY AND BACKGROUND.

          The following table provides certain information about each of the
Reporting Persons.

<TABLE>
<CAPTION>
                                        CITIZENSHIP OR STATE OF            PRINCIPAL OCCUPATION OR 
NAME AND ADDRESS                        INCORPORATION/ORGANIZATION         BUSINESS
- ----------------                        --------------------------         -----------------------
<S>                                     <C>                                 <C>
Furman Selz Investors II L.P.           Delaware                            Limited Partnership for
("Investors")                                                               Investments
55 East 52nd Street, 37th Floor
New York, New York 10055-0002

FS Employee Investors LLC               Delaware                            Limited Liability Company for
("Employee Investors")                                                      Investments
55 East 52nd Street, 37th Floor
New York, New York 10055-0002

FS Parallel Fund L.P.                   Delaware                            Limited Partnership for
("Parallel Fund")                                                           Investments
55 East 52nd Street, 37th Floor
New York, New York 10055-0002

FS Private Investments LLC              Delaware                            Manager of Investors, Employee
("Private Investments")                                                     Investors and Parallel Fund
55 East 52nd Street, 37th Floor
New York, New York 10055-0002

Furman Selz Investments II LLC
("FS Investments II")                   Delaware                            Holding Company
55 East 52nd Street
New York, NY 10055-0002

ING Baring Furman Selz LLC              Delaware                            Investment Banking
("ING Baring")
55 East 52nd Street
New York, NY  10055-0002

ING Merger, Inc.                        Delaware                            Holding Company
("ING Merger")
667 Madison Avenue
New York, New York  10021

ING (U.S.) Financial Holdings           Delaware                            Holding Company
Corporation 
("ING (U.S.)")
135 East 57th Street
New York, New York  10022

ING Bank N.V.                           The Netherlands                     Bank
("ING Bank")
P.O. Box 810
1000 AV
Amsterdam, The Netherlands

ING Groep N.V.                          The Netherlands                     Insurance Company
("ING Groep")
Strawinskylaan 2631
1097 ZZ Amsterdam

Brian P. Friedman                       USA                                 Managing Member of Private
55 East 52nd Street, 37th Floor                                             Investments
New York, New York  10055-0002

James L. Luikart                        USA                                 Managing Member of Private
55 East 52nd Street, 37th Floor                                             Investments
New York, New York  10055-0002
</TABLE>

          The Executive Board of ING Groep is the following:

Executive Board:

          G.J.A. van der Lugt
          drs. J.H. Holsboer
          mr. E. Kist
          ir. J.H.M. Lindenbergh
          drs.ing. C. Maas
          M. Minderhood
          dr. A.H.G. Rinnooy Kan
          M. Tilmant

          The directors and executive officers of ING Merger, Inc. are the
following:

Directors:

          Fernando Gentil
          Wietze Prinsen

Officers:

          Fernando Gentil          President
          David Distler            Vice President
          Benjamin Emanuel         Vice President
          David Rutkin             Vice President
          Amanda D. Lister         Treasurer
          William Austin           General Counsel and Secretary
          Steven D. Blecher        Senior Managing Director and Assistant 
                                   Secretary
          Thalia Cody              Assistant General Counsel and Assistant 
                                   Secretary
          Edmund A. Hajim          Senior Managing Director
          Ivy Hwang                Assistant General Counsel and Assistant 
                                   Secretary
          Joseph Kaminsky          Senior Vice President
          Amanda D. Lister         Managing Director
          Robert J. Miller         Assistant Treasurer
          Wietze Prinsen           Senior Managing Director
          Hanne P. Thrush          Assistant Secretary

          The directors and executive officers of ING (U.S.) Financial Holdings
Corporation are the following:

Directors:

          Fernando Gentil
          Bart Staal

Officers:

          Fernando Gentil          President
          Albert Staal             Executive Vice President
          Christopher Rowland      Chief Financial Officer
          Joseph Kaminsky          Senior Vice President
          Marianne Ruggiero        Senior Vice President
          Benjamin Emanuel         Vice President
          David Rutkin             Vice President
          Phil Schulze             Vice President
          Robert Tankoos           Vice President
          William A. Austin        Secretary and General Counsel
          Ivy Hwang                Assistant General Counsel and Assistant
                                   Secretary
          Hanne P. Thrush          Assistant Secretary

          The Executive Board of ING Bank is the following:

          G.J.A van der Lugt
          drs. J.H. Holsboer
          mr. E. Kist
          ir. J.H.M. Lindenbergh
          drs.ing. C. Maas
          dr. A.H.G. Rinnooy Kan
          M. Tilmant

          ING Groep owns 100% of ING Bank, which owns 100% of ING (U.S.), which
owns 100% of ING Merger, which is the sole managing member and owner of 100% of
the interests of ING Baring, which is the sole managing member and owner of 100%
of the interests of FS Investments II, which is the sole managing member and
owner of 100% of the interests of, Employee Investors, which directly owns
223,112 shares of Common Stock of the Company. FS Investments II is the sole
general partner of Investors, which directly owns 2,602,300 shares of Common
Stock of the Company. FS Investments II is the sole general partner of Parallel
Fund, which directly owns 126,569 shares of Common Stock of the Company.

          ING Baring also owns directly an additional 50,000 shares of Common
Stock of the Company.

          As a result of its role as manager of Investors, Employee Investors
and Parallel Fund (the "Funds"), Private Investments may be deemed to be the
beneficial owner of the shares held by the Funds.

          As a result of Brian P. Friedman's and James L. Luikart's positions as
Managing Members of Private Investments, they may be deemed to be the beneficial
owners of the shares beneficially owned by Private Investments and therefore
deemed to be the beneficial owners of the shares held by the Funds.

          (d) and (e). None of the Reporting Persons, and to the knowledge of
the Reporting Persons, none of the other individuals named have, within the last
five years, been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors), or have been a party to a civil proceeding
of a judicial or administrative body of competent jurisdiction and as a result
of such proceeding been or are subject to a judgment, decree or final order
enjoining future violations of, or prohibiting or mandating activities subject
to, federal or state securities laws or finding any violations with respect to
such laws.

<PAGE>

          (f) Brian P. Friedman and James L. Luikart are United States citizens.

          The filing of this statement shall not be construed as an admission
that Private Investments, FS Investments II, ING Baring, ING Merger, ING (U.S.),
ING Bank, ING Groep, Brian P. Friedman or James L. Luikart are, for purposes of
Sections 13(d) or 13(g) of the Securities Exchange Act of 1934, the beneficial
owner of any shares covered by this statement.

ITEM 3.   SOURCE AND AMOUNT OF FUNDS.

          The funds for the purchase of Direct Shares by Investors and Parallel
Fund were provided from the partner's capital contributions.

          The funds for the purchase of Direct Shares by Employee Investors were
provided from member contributions.

          The funds for the purchase of Direct Shares by ING Baring were
provided from working capital.

          Pursuant to an amendment to the Letter Agreement among Private
Investments, BancBoston Ventures Inc. and the Company with respect to financial
advisory services to be provided by Private Investments to the Company, Private
Investments will receive, as of the Second Amendment Closing Date (as defined in
Item 4 below), 150,000 shares of Common Stock. The aggregate dollar value of
such shares of Common Stock is $525,000.

ITEM 4.   PURPOSE OF TRANSACTION.

          On May 13, 1998, Investors, Employee Investors and Parallel Fund
purchased (i) 4,628, 397 and 225 Preferred Shares, respectively, (ii)
$5,950,667, $509,668 and $289,665, aggregate principal amount, respectively, of
Subordinated Notes and (iii) Warrants to purchase an aggregate of 1,399,662,
119,961 and 68,095 shares of Common Stock, respectively, pursuant to the
Purchase Agreement.

          On February 16, 1999, the Company entered into a Loan Agreement with
Alpharma USPD Inc. ("Lender") and Alpharma Inc. ("Parent"), pursuant to which
Lender agreed to lend to the Company up to $40,000,000 (the "Loan"). In
connection with the Loan, the Company agreed to grant to the Lender an option
during a specified period during the first half of 2002 to purchase all of the
outstanding shares of the Company's Common Stock. The Company and a wholly-owned
subsidiary of the Company, entered into an Agreement and Plan of Merger,
pursuant to which, each share of Common Stock will be converted into the right
to receive one Depositary Share. Each Depositary Share will evidence one share
of common stock of the Company that will be subject to the Lender's option. The
Company, Lender and Parent executed a Master Agreement as of February 16, 1999,
which sets forth the terms and conditions of the consummation of the above
referenced transactions (the "Alpharma Transaction") and specifies the closing
date of the Alpharma Transaction (the "Alpharma Transaction Closing Date").

<PAGE>

          In connection with the Alpharma Transaction, an amendment to the
Purchase Agreement was executed on February 16, 1999, pursuant to which the
Company, among other things, agreed to issue and sell 300,000 shares of its
Common Stock for an aggregate purchase price of $900,000 to the Purchasers as of
the Alpharma Transaction Closing Date. Pursuant to this Amendment to the
Purchase Agreement, each of Investors, Employee Investors and Parallel Fund
agreed to (i) purchase an aggregate of 225,000 shares of Common Stock (the
"Direct Purchase Shares") for an aggregate purchase price of $675,000 and (ii)
exercise all of their Warrants as of the Alpharma Transaction Closing Date, at
an exercise price adjusted from $4.75 per share of Common Stock to $3.00 per
share of Common Stock.

          Also in connection with the Alpharma Transaction, as of the Alpharma
Transaction Closing Date, the Company will exchange the outstanding Preferred
Shares as of such date for its Convertible Notes in accordance with the terms of
the Preferred Shares. The Convertible Notes are convertible at the option of the
holder into shares of Common Stock and will automatically convert into Common
Stock under certain circumstances. Pursuant to the terms of the Convertible
Notes, the conversion price and number of shares of Common Stock issuable upon
the conversion of the Convertible Notes are subject to adjustment upon the
occurrence of certain events, such as stock splits, stock dividends, mergers,
reclassifications and similar corporate events.

          If the Alpharma Transaction Closing Date has not occurred as of
September 30, 1999, this Amendment to the Purchase Agreement will automatically
terminate.

ITEM 5.   INTEREST IN SECURITIES OF THE ISSUER.

          (a)-(b)

<TABLE>
<CAPTION>
                         NUMBER OF SHARES         SHARED         SHARED           SOLE         SOLE 
                         TO BE BENEFICIALLY       VOTING         INVESTMENT       VOTING       INVESTMENT     PERCENTAGE
NAME                     OWNED                    POWER          POWER            POWER        POWER          OF CLASS
- ----                     ------------------       ---------      ----------       ------       ----------     ----------

<S>                      <C>                      <C>            <C>              <C>          <C>            <C> 
Private Investments      3,101,981                3,101,981      3,101,981        0            0              36.8

Investors                2,602,300                2,602,300      2,602,300        0            0              31.3

Employee Investors         223,112                  223,112        223,112        0            0               3.0

Parallel Funds             126,569                  126,569        126,569        0            0               1.7

FS Investments II        2,951,981                2,951,981      2,951,981        0            0              35.0

ING Baring               3,001,981                3,001,981      3,001,981        0            0              35.6

ING Merger               3,001,981                3,001,981      3,001,981        0            0              35.6

ING (U.S.)               3,001,981                3,001,981      3,001,981        0            0              35.6

ING Bank                 3,001,981                3,001,981      3,001,981        0            0              35.6

ING Groep                3,001,981                3,001,981      3,001,981        0            0              35.6

Brian P. Friedman        3,101,981                3,101,981      3,101,981        0            0              36.8

James L. Luikart         3,101,981                3,101,981      3,101,981        0            0              36.8
</TABLE>


<PAGE>

          As of February 16, 1999, the Company had 7,026,445 shares of Common
Stock outstanding.

          (b) See the answer to Item 2 hereof.

          (c) Other than the transactions described herein, no transactions by
any of the Reporting Persons required to be reported by this Item have taken
place in the last sixty (60) days.

          (d) Not applicable.

          (e) Not applicable.

ITEM 6.   CONTRACTS, ARRANGEMENTS, UNDERSTANDING OR RELATIONSHIPS WITH 
          RESPECT TO SECURITIES OF THE ISSUER.


          Private Investments is the manager of each of Investors, Employee
Investors and Parallel Fund. The general partner of each of Investors and
Parallel Fund and the managing member of Employee Investors have delegated all
relevant rights to Private Investments.

          Brian P. Friedman and James L. Luikart are the managing members of
Private Investments.

ITEM 7.   MATERIAL FILED AS EXHIBITS.                                     PAGE

          A.   Joint Reporting Agreement and Power of Attorney on
               Behalf of Each Reporting
               Person.................................................

          B.   Second Amendment, dated February 16, 1999, to the
               Securities Purchase Agreement dated May 13,
               1998...................................................

          C.   Amendment, dated February 16, 1999, to the Letter
               Agreement among Private Investments, BancBoston
               Ventures Inc. and the
               Company................................................

<PAGE>

                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated:  February    , 1999

                                   FURMAN SELZ INVESTORS II L.P.

                                   By: FS PRIVATE INVESTMENS LLC

                                   By:  /s/ Brian P. Friedman
                                       -------------------------
                                       Name:   Brian P. Friedman
                                       Title:  Managing Member             

                                   FS EMPLOYEE INVESTORS LLC

                                   By: FS PRIVATE INVESTMENS LLC


                                   By: /s/ Brian P. Friedman
                                      --------------------------
                                      Name:   Brian P. Friedman
                                      Title:  Managing Member


                                   FS PRIVATE PARALLEL FUND, L.P.

                                   By: FS PRIVATE INVESTMENS LLC

                                   By: /s/ Brian P. Friedman
                                      ---------------------------
                                      Name:   Brian P. Friedman
                                      Title:  Managing Member             


                                   BY: FS PRIVATE INVESTMENTS LLC,


                                   By: /s/ Brian P. Friedman
                                      -----------------------------
                                       Name:  Brian P. Friedman
                                       Title: Managing Member


                                   FS PRIVATE INVESTMENTS LLC  MANAGER


                                   By: /s/ Brian P. Friedman
                                      ------------------------------------
                                      Name:  Brian P. Friedman
                                      Title: Managing Member


                                   FURMAN SELZ INVESTMENTS II LLC


                                   By: /s/ Steven Blecher
                                      ------------------------------------
                                      Name:  Steven Blecher
                                      Title:


                                   ING BARING FURMAN SELZ LLC
                              

                                   By: /s/ Steven Blecher
                                      ------------------------------------
                                      Name:  Steven Blecher
                                      Title: Vice Chairman
                                          

                                   ING MERGER, INC.


                                   By: /s/ Steven Blecher
                                      ------------------------------------
                                      Name:  Steven Blecher
                                      Title: Senior Managing Director and
                                                Assistant Secretary


                                   ING (U.S.) FINANCIAL HOLDINGS
                                   CORPORATION


                                   By: /s/ William A. Austin
                                      ------------------------------------
                                      Name:  William A. Austin
                                      Title: Secretary


                                   ING BANK N.V.


                                   By: /s/ J.H.J. Houben
                                       ------------------------------------
                                       Name:   J.H.J. Houben
                                       Title:


                                  By: /s/ P.F.M. Van Lierop
                                      ------------------------------------
                                      Name:  P.F.M. Van Lierop
                                      Title: Senior Legal Advisor


                                  ING GROEP N.V.


                                  By: /s/ J.H.J. Houben
                                      ------------------------------------
                                      Name:  J.H.J. Houben
                                      Title:


                                  /s/ Brian Friedman
                                  ------------------------------------
                                  Name:  Brian P. Friedman


                                  /s/ James L. Luikart 
                                  ------------------------------------
                                  Name:  James L. Luikart




                                                                  EXHIBIT A


                            JOINT REPORTING AGREEMENT
                                       AND
                                POWER OF ATTORNEY


          WHEREAS, the statement or amended statement of Schedule 13D (the
"Joint Statement") to which this joint reporting agreement and power of attorney
(the "Agreement") is an exhibit is being filed on behalf of two or more persons
(collectively, the "Reporting Persons"); and

          WHEREAS, the Reporting Persons prefer to file the Joint Statement on
behalf of all of the Reporting Persons rather than individual statements on
Schedule 13D on behalf of each of the Reporting Persons;

          NOW THEREFORE, the undersigned hereby agree as follows with each of
the other Reporting Persons:

          1. Each of the Reporting Persons is responsible for the timely filing
of the Joint Statement and any amendments thereto.

          2. Each of the Reporting Persons is responsible for the completeness
and accuracy of the information concerning such Reporting Person contained in
the Joint Statement.

          3. None of the Reporting Persons is responsible for the completeness
or accuracy of the information concerning the other Reporting Persons contained
in the Joint Statement, unless such Reporting Person knows or has reason to
believe that such information is inaccurate.

          4. The undersigned agrees that the Joint Statement is, and any
amendment thereto will be, filed on behalf of each of the Reporting Persons.

          5. Each of ING Baring Furman Selz LLC, ING Merger, Inc., ING (U.S.)
Financial Holdings Corporation, ING Bank N.V., ING Groep N.V. hereby appoints
Robert Miller as attorney-in-fact with authority to execute and deliver on
behalf of it any and all documents (including any amendments thereto) required
to be filed or otherwise executed and delivered by it pursuant to the Securities
Exchange Act of 1934, as amended, the Securities Act of 1933, as amended, all
other federal, state and local securities and corporation laws, and all
regulations promulgated thereunder.

          6. Each of Brian P. Friedman and James L. Luikart hereby appoints
Brian P. Friedman and James L. Luikart, and each of them, as attorney-in-fact
with authority to execute and deliver on his behalf any and all documents
(including any amendments thereto) required to be filed or otherwise executed
and delivered by him pursuant to the Securities Exchange Act of 1934, as
amended, the Securities Act of 1933, as amended, all other federal, state and
local securities and corporation laws, and all regulations promulgated
thereunder.

          7. This Agreement may be executed in one or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same document.

Dated:  February    , 1999


                                      ING BARING FURMAN SELZ LLC


                                      By: /s/ Steven Blecher
                                          ------------------------------------
                                          Name:  Steven Blecher
                                          Title: Vice Chairman
                                          

                                      ING MERGER, INC.


                                    By: /s/ Steven Blecher
                                        ------------------------------------
                                        Name:   Steven Blecher
                                        Title:  Senior Managing Director and
                                                Assistant Secretary


                                    ING (U.S.) FINANCIAL HOLDINGS
                                    CORPORATION


                                    By:  /s/ William A. Austin
                                         ------------------------------------
                                          Name:  William A. Austin
                                          Title: Secretary


                                    ING BANK N.V.


                                    By:  /s/ J.H.J. Houben
                                         ------------------------------------
                                         Name:   J.H.J. Houben
                                         Title:
  

                                    By:  /s/ P.F.M. Van Lierop
                                         ------------------------------------
                                         Name: P.F.M. Van Lierop
                                        Title: Senior Legal Advisor


                                    ING GROEP N.V.


                                    By: /s/ J.H.J. Houben
                                        ------------------------------------
                                        Name:  J.H.J. Houben
                                        Title:


                                    /s/ Brian P. Friedman
                                    -----------------------------------
                                    Brian P. Friedman


                                    /s/ James L. Luikart
                                    ------------------------------------
                                    James L. Luikart




                                                                  EXHIBIT B

                                SECOND AMENDMENT

                             DATED FEBRUARY 16, 1999

                                     TO THE

                          SECURITIES PURCHASE AGREEMENT

                               DATED MAY 13, 1998

                                  BY AND AMONG

                          FURMAN SELZ INVESTORS II L.P.
                            FS EMPLOYEE INVESTORS LLC
                              FS PARALLEL FUND L.P.
                            BANCBOSTON VENTURES INC.
                                 FLYNN PARTNERS

                                       AND

                             ASCENT PEDIATRICS, INC.

          SECOND AMENDMENT dated as of the 16th day of February 1999 (the
"Second Amendment") among Ascent Pediatrics, Inc. (the "Company"), Furman Selz
Investors II L.P. ("Investors"), FS Employee Investors LLC ("Employee"), FS
Parallel Fund L.P. ("Parallel"), BancBoston Ventures Inc. ("BancBoston") and
Flynn Partners ("Flynn"), (each of Investors, Employee, Parallel, BancBoston and
Flynn are herein referred to as "Purchaser", and collectively, the
"Purchasers").

          WHEREAS, the Company and the Purchasers are parties to a Securities
Purchase Agreement dated as of May 13, 1998, as amended September 30, 1998 (the
"Series G Purchase Agreement");

          WHEREAS, the Company is negotiating a Loan Agreement (the "Loan
Agreement") with Alpharma, Inc., a Delaware corporation ("Parent"), and Alpharma
USPD Inc., a Maryland corporation and a wholly-owned subsidiary of Parent
("Alpharma"), pursuant to which the Company proposes to issue and sell to
Alpharma a 7.5% Convertible Subordinated Note in an aggregate principal amount
of up to $40,000,000 (the "Alpharma Convertible Note");

          WHEREAS, in connection with the Loan Agreement, the Company and
Alpharma will enter into a Registration Rights Agreement (the "Registration
Rights Agreement"), pursuant to which the Company will grant Alpharma certain
demand and incidental registration rights with respect to the shares of Common
Stock issued or issuable upon conversion of the Alpharma Convertible Note (the
"Alpharma Registrable Shares");

          WHEREAS, in connection with the Loan Agreement, (i) the Company and
Bird Merger Corporation, a Delaware corporation and wholly-owned subsidiary of
the Company (the "Merger Subsidiary"), will enter into an Agreement and Plan of
Merger (the "Merger Agreement"), (ii) the Company, Alpharma and Parent will
enter into a Master Agreement (the "Master Agreement"), and (iii) the Company,
Alpharma and State Street Bank and Trust Company will enter into a Depositary
Agreement (the "Depositary Agreement" and together with the Merger Agreement,
the Registration Rights Agreement and the Master Agreement, the "Ancillary
Agreements"), pursuant to which, among other things the Company will assign to
Alpharma the right and option (the "Call Option"), upon the terms and conditions
set forth in the Depositary Agreement, to purchase all of the outstanding shares
of common stock, $.00004 par value per share, of the Company (the "Common
Stock"); and

          WHEREAS, the Purchasers are the holders of all of (i) the Preferred
Stock and Preferred Conversion Shares issuable upon conversion of the Preferred
Stock, (ii) the principal amount of the Subordinated Notes, and (iii) the
Warrants and Warrant Shares issuable upon exercise of the Warrants.

          NOW THEREFORE, in order to induce Alpharma to enter into the Loan
Agreement and the Ancillary Agreements and to consummate the transactions
contemplated thereby and in consideration of these premises, the mutual
covenants and agreements set forth herein and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto agree as follows:


                                    ARTICLE I
                         DEFINITIONS AND INTERPRETATION

          SECTION 1.1 DEFINITIONS AND INTERPRETATION.

          (a) All capitalized terms used herein which are not otherwise
specifically defined herein shall have the respective meaning as ascribed
thereto in the Series G Purchase Agreement.

          (b) For purposes of this Second Amendment and the Series G Purchase
Agreement:

          "ALPHARMA CLOSING DATE" shall mean the Closing Date as such term is
defined in the Master Agreement.

          "DIRECT PURCHASE SHARES" shall have the meaning ascribed to such term
in Section 5.1 of this Second Amendment.

          "SECOND AMENDMENT CLOSING DATE" shall have the meaning ascribed to
such term in Section 5.3 of this Second Amendment.

          (c) Unless otherwise expressly indicated, all references contained
herein to SECTIONS or other subdivisions or SCHEDULES refer to the corresponding
SECTIONS and other subdivisions or SCHEDULES of the Series G Purchase Agreement.

          (d) The sections and the headings in the sections in this Second
Amendment are for convenience only. Said sections and headings shall not be
deemed to be part of this Second Amendment and in no way define, limit, extend
or describe the scope or intent of its provisions.

                                   ARTICLE II
                    CERTAIN AGREEMENTS, WAIVERS AND CONSENTS

          SECTION 2.1 REGISTRATION RIGHTS. The Purchasers hereby consent to the
grant of registration rights to Alpharma pursuant to the Registration Rights
Agreement and agree that, in the event that (i) Alpharma initiates an
underwritten offering of shares of Common Stock pursuant to the Registration
Rights Agreement, (ii) the Holders (as defined in Section 10.2 of the Series G
Purchase Agreement) elect pursuant to Section 10.4 of the Series G Purchase
Agreement to include Registrable Securities (as defined in the Series G Purchase
Agreement) in such offering, and (iii) the managing underwriter of such offering
determines that the number of shares to be included in such offering needs to be
reduced, then the number of Registrable Securities to be included in the
offering shall be reduced or eliminated, as determined by the managing
underwriter of such offering, prior to any reduction in the number of Alpharma
Registrable Shares included in the offering. The Purchasers hereby waive
compliance with the requirements set forth in the last sentence of Section 10.9
of the Series G Purchase Agreement as such requirements apply to the
Registration Rights Agreement.

          SECTION 2.2 WAIVER OF EVENTS OF DEFAULT. The Purchasers hereby waive
any Events of Default under Section 13.1 of the Series G Purchase Agreement
arising on or before the date hereof, including without limitation, (i) any
Event of Default resulting from the formation of the Merger Subsidiary as a
wholly-owned subsidiary of the Company, and (ii) any Event of Default resulting
from any failure of the Company to provide to the Purchasers any of the
financial information or notices set forth in Section 7.1 of the Series G
Purchase Agreement and agree that the Company shall have no further obligation
to provide any of such financial information or notices to the extent such
financial information or notices were otherwise required to be provided prior to
the date hereof.

          SECTION 2.3 RIGHT OF FIRST REFUSAL. The Purchasers hereby waive any
rights of first refusal held by the Purchasers under Section 7.7 of the Series G
Purchase Agreement which were, are or may be, applicable to (i) the issuance of
any shares of New Common Stock, Depositary Receipts or Depositary Shares (each
as defined in the Depositary Agreement) pursuant to the Merger Agreement or the
Depositary Agreement, (ii) the issuance of the Alpharma Convertible Note and the
shares of Common Stock issuable upon conversion of the Alpharma Convertible
Note.

          SECTION 2.4 SENIORITY OF NOTES. The Purchasers hereby agree that the
Alpharma Convertible Note issued pursuant to the Loan Agreement shall rank pari
passu in right of payment with the Subordinated Notes and any debt securities
issuable upon conversion or exchange of the shares of Preferred Stock of the
Company issued to the Purchasers pursuant to the Series G Purchase Agreement,
except as otherwise provided in the Subordination Agreement dated as of February
16, 1999 among the Company, the Purchasers and Alpharma.

          SECTION 2.5 CONSENT TO LOAN AGREEMENT AND ANCILLARY AGREEMENTS. The
Purchasers hereby consent, in all respects under the Series G Purchase
Agreement, to the execution of the Loan Agreement and the Ancillary Agreements
and to the consummation of the transactions contemplated thereby, including
without limitation the incurrence of additional Indebtedness (as defined in the
Series G Purchase Agreement) by the Company.

          SECTION 2.6 CONSENT TO LETTER AGREEMENT. The Purchasers hereby
consent, in all respects under the Series G Purchase Agreement, to the letter
agreement dated February 16, 1999 among the Company and FS Private Investments
LLC. The parties agree that paragraph 2 of such letter agreement shall be an
amendment to Article X of the Series G Purchase Agreement.

                                   ARTICLE III
                  AMENDMENTS TO THE SERIES G PURCHASE AGREEMENT

          SECTION 3.1 AMENDMENT TO SECTION 3.1. Section 3.1 of the Series G
Purchase Agreement is hereby amended by deleting in its entirely the text of the
penultimate sentence thereof and inserting in lieu thereof the following:

               "Material Adverse Effect" means, when used in connection with the
               Company, any development, change or effect that is materially
               adverse to the business, properties (including, without
               limitation, Intellectual Property (as defined in Section 3.11),
               assets, net worth, financial conditions, results of operations or
               future prospects (including, without limitation, future equity
               value) of the Company and its Subsidiaries taken as a whole."

         SECTION 3.2 AMENDMENT TO SECTIONS 7.1 THROUGH 7.4. Section 7.1 through
7.4 of the Series G Purchase Agreement are hereby amended by deleting in its
entirety the text thereof and inserting in lieu thereof the following:

               "7.1  REPORTS. The Company will deliver to each Purchaser the
                     following:

               (a)  within thirty (30) days after the end of each of the twelve
                    (12) monthly accounting periods in each fiscal year (or when
                    furnished to the Board of Directors, if earlier), unaudited
                    consolidated statements of income and retained earnings and
                    cash flows of the Company and its Subsidiaries, if any, for
                    each monthly period and for the period from the beginning of
                    such fiscal year to the end of such monthly period, together
                    with consolidated balance sheets of the Company and its
                    Subsidiaries, if any, as at the end of each monthly period,
                    setting forth in each case comparisons to budget and to
                    corresponding periods in the preceding fiscal year which
                    statements will be prepared in accordance with GAAP,
                    consistently applied subject to the absence of footnotes and
                    year-end adjustments;

               (b)  within ninety (90) days after the end of each fiscal year,
                    consolidated statements of income and retained earnings and
                    cash flow of the Company and its Subsidiaries, if any, for
                    the period from the beginning of each fiscal year to the end
                    of such fiscal year, and consolidated balance sheets as at
                    the end of such fiscal year, setting forth in each case in
                    comparative form corresponding figures for the preceding
                    fiscal year, which statements will be prepared in accordance
                    with GAAP, consistently applied (except as approved by the
                    accounting firm examining such statements and disclosed by
                    the Company) and will be accompanied by a report on the
                    consolidated statements of a public accounting firm
                    reasonably acceptable to the Purchasers or one of the public
                    accounting firms currently known as the "Big Five" (either,
                    an "Approved Accounting Firm");

               (c)  within ten (10) days after transmission thereof, copies of
                    all financial statements, proxy statements, reports and
                    other communications which the Company sends to its
                    stockholders, copies of all registration statements and all
                    regular, special or periodic reports which it files with the
                    SEC or with any securities exchange on which any of the
                    securities of the Company are then listed or proposed to be
                    listed, and copies of all press releases made generally
                    available by the Company to the public concerning material
                    developments in the business of the Company and its
                    Subsidiaries, if any;

               (d)  promptly after the occurrence thereof (but in any event
                    within seven (7) days after such occurrence is known to the
                    Company) notice of any condition or event which constitutes,
                    or the occurrence of (i) an event which would lead the
                    Company to believe that the Company is not in compliance in
                    material respects with the covenants in this Agreement or
                    (ii) the institution or threatened institution of an action,
                    suit or proceeding against the Company or any of its
                    Subsidiaries by or before any court, regulatory authority,
                    administrative agency or any other governmental agency or
                    body, domestic or foreign, which, if adversely decided,
                    could have a Material Adverse Effect; and

               (e)  at least thirty (30) days prior to the end of each fiscal
                    year, a detailed annual operating budget and business plan
                    for the Company and its Subsidiaries, if any, for such
                    fiscal year. Such budgets shall be prepared on a monthly
                    basis, displaying consolidated statements of anticipated
                    cash flow and projected consolidated balance sheets, setting
                    forth in each case the assumption (which assumptions and
                    projections shall represent and be based upon the good faith
                    best judgment in respect thereof of the Chief Executive
                    Officer of the Company) behind the projections contained in
                    such financial statements, and which budgets shall have been
                    approved by the Board of Directors of the Company or prior
                    to the beginning of each twelve-month period to which they
                    pertain and, promptly upon preparation thereof, any other
                    budgets that the Company may prepare and any revisions of
                    such annual or other budgets.

          7.2 ACCOUNTS AND RECORDS. The Company shall keep true records and
books of account in which entries will be made of all dealings or transactions
in relation to the business and affairs of the Company and its Subsidiaries, if
any, in accordance with GAAP, to the extent applicable, applied on a consistent
basis.

          7.3 INSPECTION. The Company shall permit Furman Selz Investments LLC,
BancBoston Ventures Inc. or any of their respective officers, employees,
representatives or such other Person as Furman Selz Investments LLC or
BancBoston Ventures Inc. may designate, during regular business hours of the
Company, upon reasonable prior notice, to visit and inspect the offices and
properties of the Company and to (i) review and make extracts or copies of the
books, accounts and records of the Company, and (ii) discuss the affairs,
finances and accounts of the Company, with the Company's Officers, members of
the Board of Directors, Approved Accounting Firm, consultants and attorneys.

          7.4 INDEPENDENT ACCOUNTANTS. The Company will retain an Approved
Accounting Firm to audit the Company's financial statements at the end of each
fiscal year. In the event the services of the Approved Accounting Firm shall be
terminated, the Company shall promptly thereafter seek to engage another
Approved Accounting Firm.

          SECTION 3.3 AMENDMENTS TO SECTIONS 7.5.

          (a) Section 7.5(a) of the Series G Purchase Agreement is hereby
amended by deleting in its entirety the text thereof and inserting in lieu
thereof the following:

                  "From and after the Alpharma Closing Date and prior to the
         Option Expiration Date, the Company's Board of Directors shall consist
         of a minimum of seven and a maximum of eleven directors. The Company
         agrees to hold meetings of its Board of Directors at least four times a
         year, at least once per calendar quarter. The Purchasers shall have the
         right to have two (2) nominees included on the Board of Directors'
         slate of nominees to stand for election to the Board of Directors. The
         directors of the Company designated by the Purchasers pursuant to this
         Section 7.5(a) shall be referred to hereinafter as the "Purchaser
         Directors."'

          (b) Section 7.5(b) of the Series G Purchase Agreement is hereby
amended by deleting in its entirety the text thereof and inserting in lieu
thereof the following:

                  "If at any time the Board of Directors designates a committee
         or committees to act on behalf of the Board, at least one (1) of the
         Purchaser Directors shall be a member of such committee or committees."

          (c) Section 7.5(d) of the Series G Purchase Agreement is hereby
amended by deleting the word "the" before the term "Purchaser Director" in the
first line thereof and inserting the word "each" in lieu thereof.

          SECTION 3.4 ADDITION OF SECTION 7.10. Article VII of the Series G
Purchase Agreement is hereby amended by adding the following immediately after
Section 7.9:

              "7.10 INSURANCE. The Company shall keep in force with responsible
          insurers, policies of insurance providing coverage, limits and 
          deductibles customary in the Company's industry."

          SECTION 3.5 AMENDMENT TO SECTION 7.10. Section 7.10 of the Series G
Purchase Agreement is hereby amended by renumbering the same as Section 7.11.

          SECTION 3.6 AMENDMENT TO SECTIONS 8.1 THROUGH 8.12. Sections 8.1
through 8.12 of the Series G Purchase Agreement are hereby amended by deleting
in its entirety the text thereof and inserting in lieu thereof the following:

          "8.1 BORROWED MONEY INDEBTEDNESS. Create, incur, suffer or permit to
     exist, or assume or guarantee, or become or remain liable with respect to
     any Borrowed Money Indebtedness, except the following:

               (a)  the Alpharma Convertible Note;

               (b)  the Borrowed Money Indebtedness existing on the date of the
                    Second Amendment and disclosed in the Financial Statements,
                    and all renewals, extensions and replacements (but not
                    increases) of any of the foregoing, provided that the
                    accrual of interest on such liabilities, so long as it is
                    not converted to principal, shall not be deemed to increase
                    such liabilities;

               (c)  principal of up to $50,000,000 of Borrowed Money
                    Indebtedness in the aggregate outstanding at any time (which
                    (i) prior to or on the Option Expiration Date must consist
                    solely of Screened Project Indebtedness and (ii) thereafter,
                    may include up to $10,000,000 of Borrowed Money Indebtedness
                    that is not Screened Project Indebtedness), plus any accrued
                    interest thereon;

               (d)  purchase money Indebtedness permitted by Section 8.10 to the
                    extent liens securing the same are allowed by the other
                    provisions of this Agreement;

               (e)  capitalized lease obligations to the extent leases with
                    respect thereto are allowed by the other provisions of this
                    Agreement;

               (f)  the Convertible Notes;

               (g)  on or prior to the Option Expiration Date, any Screened
                    Project Indebtedness that is convertible directly or
                    indirectly into Common Stock; and

               (h)  after the Option Expiration Date, any Borrowed Money
                    Indebtedness that is convertible directly or indirectly into
                    Common Stock.

          8.2 LIENS. Create or suffer to exist any Lien upon any of its Property
     now owned or hereafter acquired, or acquire any Property upon any
     conditional sale or other title retention device or arrangement or any
     purchase money security agreement; provided, however, that the Company and
     any Subsidiaries of the Company may create or suffer to exist Permitted
     Liens.

          8.3 CONTINGENT LIABILITIES. Directly or indirectly guarantee the
     performance or payment of, or purchase or agree to purchase, or assume or
     contingently agree to become or be secondarily liable in respect of, any
     obligation or liability of any other Person except for:

               (a)  the endorsement of checks or other negotiable instruments in
                    the ordinary course of business;

               (b)  obligations disclosed to the Purchasers in the Financial
                    Statements (but not increases of such obligations after the
                    First Loan Date, provided that the accrual of interest on
                    such obligations, so long as it is not converted to
                    principal, shall not be deemed to increase such
                    obligations);

               (c)  obligations in respect of employees which shall not exceed
                    an aggregate amount equal to $200,000 at any time
                    outstanding; and

               (d)  those liabilities permitted under Section 8.1 hereof.

          8.4 MERGERS, CONSOLIDATIONS AND DISPOSITIONS AND ACQUISITIONS OF
     ASSETS. In any single transaction or series of related transactions,
     directly or indirectly:

               (a)  liquidate or dissolve;

               (b)  be a party to any merger or consolidation unless (i) no
                    Default or Event of Default has occurred that is then
                    continuing; (ii) immediately thereafter and giving effect
                    thereto, no event will occur and be continuing which
                    constitutes a Default; (iii) the Company, or the Subsidiary,
                    if any, is the surviving Person; and (iv) the Purchasers are
                    given at least twenty (20) days prior notice of such merger
                    or consolidation or such lesser number of days as is
                    practicable;

               (c)  sell, convey or lease all or substantially all of its
                    assets, except for the sale of property in the ordinary
                    course of business;

               (d)  acquire all or a substantial portion of the assets or stock
                    of any person whether by merger or otherwise other than in a
                    transaction or series of transactions that constitute a
                    Screened Project, provided that this subsection shall not
                    prevent any Project funded with the proceeds of the First
                    Loan, any Unrestricted Loan or Project Loans; or

               (e)  pledge, transfer or otherwise dispose of any equity interest
                    in any of its Subsidiaries, if any exist, or issue or permit
                    any of its Subsidiaries, if any exist, to issue any
                    additional equity interests except to the Company or another
                    of its Subsidiaries. Nothing in this Agreement shall
                    prohibit the Company from selling obsolete equipment or from
                    replacing used equipment in the ordinary course of business.

          8.5 REDEMPTION, DIVIDENDS AND DISTRIBUTIONS. At any time, except as
     contemplated by this Agreement and the Securities and by the terms of the
     Alpharma Convertible Note, by the Loan Agreement and, by the Ancillary
     Agreements: (a) redeem, retire or otherwise acquire, directly or
     indirectly, any equity interest of the Company or any of its Subsidiaries
     (other than $250,000 in any fiscal year to be used to effectuate the
     repurchase of restricted stock issued to employees, directors or
     consultants of the Company pursuant to a restricted stock agreement) or (b)
     make any distributions of any property or cash in respect of any of its
     Capital Stock.

          8.6 NATURE OF BUSINESS. Change the nature of its business or enter
     into any business which is substantially different from the development,
     manufacture and sale of pharmaceuticals principally for the pediatric
     market.

          8.7 TRANSACTIONS WITH RELATED PARTIES. Enter into any transaction or
     agreement any Officer, director or beneficial owner of five percent (5%) or
     more of the outstanding Capital Stock in the Company or any of its
     Subsidiaries (or any Affiliate of any such Person) unless the transaction
     is upon no less favorable terms than those that are obtainable from wholly
     unrelated sources. The provisions of this Section 8.7 shall not apply to
     (a) fees and compensation (including options and equity compensation) paid
     to or indemnity provided on behalf of Officers, directors, employees or
     consultants of the Company and any of its Subsidiaries, as determined by
     the Board of Directors of the Company or any of such Subsidiaries or the
     Chief Executive Officer thereof in good faith and (b) transactions
     exclusively between or among the Company's Subsidiaries, provided such
     transactions are not otherwise prohibited by this Agreement.
     Notwithstanding the prior two sentences, the Company may not pay management
     or consulting fees to such related person in excess of an aggregate of
     $50,000 per year.

          8.8 LOANS AND INVESTMENTS. Make any loan, advance, extension of credit
     or capital contribution to, or make or have any Investment in, any Person,
     or make any commitment to make any such extension of credit or investment,
     except (a) Permitted Investments, (b) normal and reasonable advances in the
     ordinary course of business to Officers and employees and (c) capital
     contributions or Investments used to fund a Project permitted by Section
     6.6 of the Loan Agreement, provided in the case of clause (c) that the
     making of such capital contribution or Investment does not cause a Default
     under any other provision hereof.

          8.9 ORGANIZATIONAL DOCUMENTS. Amend, modify, restate or supplement its
     Certificate of Incorporation or Bylaws if such action could reasonably be
     expected to adversely affect the rights of the Purchasers under this
     Agreement.

          8.10 LEASE EXPENSES; PURCHASE MONEY INDEBTEDNESS. Permit aggregate
     operating lease expenses (excluding lease payments under capital leases),
     for the Company and its Subsidiaries in the aggregate in any fiscal year,
     to exceed $500,000. Incur or create new capital lease obligations or
     purchase money Indebtedness in any fiscal year in excess of $200,000 in the
     aggregate for the Company and its Subsidiaries. Permit aggregate capital
     lease obligations and purchase money Indebtedness outstanding at any one
     time to exceed $2,000,000 in the aggregate for the Company and its
     Subsidiaries.

          8.11 SALE/LEASEBACKS. Enter into any sale/leaseback transactions
     except as permitted under the provisions of Section 8.10.

          8.12 ISSUANCE OF STOCK. On or prior to the Option Expiration Date,
     issue, or become obligated to issue shares of Capital Stock or securities
     convertible into Capital Stock, except for (i) shares of Common Stock, (ii)
     rights, warrants or options to purchase shares of Common Stock granted
     prior to March 31, 2002 and rights, warrants or options to purchase up to
     100,000 shares of Common Stock on or after March 31, 2002 (such number to
     be adjusted for stock splits or reclassifications), (iii) securities
     permitted by Section 7.1(g) of the Loan Agreement. Prior to the Option
     Expiration Date, establish a "Shareholders Rights Plan" or "Poison Pill" or
     issue any securities in connection therewith.

          8.13 SUBSIDIARIES. Form, create or acquire any Subsidiary other than
     Merger Subsidiary or permit any Person other than the Company or a wholly
     owned Subsidiary to hold an equity interest in any Subsidiary."

          SECTION 3.7 AMENDMENT TO SECTION 8.13. Section 8.13 of the Series G
Purchase Agreement is hereby amended by renumbering the same as Section 8.14.

          SECTION 3.8 AMENDMENTS TO SECTION 8.14.

          (a) Section 8.14 of the Series G Purchase Agreement is hereby amended
by renumbering the same as Section 8.15.

          (b) Section 8.15 of the Series G Purchase Agreement (as renumbered) is
hereby amended by deleting in its entirety the text thereof and inserting in
lieu thereof the following:

          "8.15 DEFINITIONS. For purposes of this Article VIII, the following
     terms shall have the meanings set forth in this Section 8.15.

          "AFFILIATE" has the meaning ascribed to it in Rule 405 promulgated
     under the Securities Act.

          "ALPHARMA CLOSING DATE" means the "Closing Date" as such term is
     defined in the Master Agreement.

          "ALPHARMA CONVERTIBLE NOTE" has the meaning set forth in the Preamble
     to the Second Amendment.

          "ANCILLARY AGREEMENTS" shall mean the Depositary Agreement, the Master
     Agreement, the Merger Agreement and the Registration Rights Agreement.

          "BOARD OF DIRECTORS" means the Board of Directors of the Company or
     any committee of the Board authorized to act for it hereunder.

          "BORROWED MONEY INDEBTEDNESS" means, with respect to any Person,
     without duplication:

                    (a) all obligations of such Person for borrowed money;

                    (b) all obligations of such Person evidenced by bonds,
               debentures, notes or similar instruments;

                    (c) all obligations of such Person under conditional sale or
               other title retention agreements relating to Property purchased
               by such Person;

                    (d) all obligations of such Person issued or assumed as the
               deferred purchase price of Property or services (excluding
               obligations of such Person to creditors for raw materials,
               inventory, services and supplies and deferred payment for
               services to employees and former employees incurred in the
               ordinary course of such Person's business);

                    (e) all capital lease obligations;

                    (f) all obligations of others secured by any Lien on
               Property or assets owned or acquired by such Person, whether or
               not the obligations secured thereby have been assumed;

                    (g) all outstanding letters of credit, surety bonds and
               currency swap or similar agreements issued for the account of
               such Person; and

                    (h) all guarantees of such Person for obligations of the
               type described above.

          "BUSINESS DAY" means any day which is neither a Saturday nor a Sunday
     nor a legal holiday on which banks are authorized or required to close in
     Boston, Massachusetts, New York, New York or in any other city in which the
     Depositary's Office (as defined in the Depositary Agreement) is located.

          "CAPITAL STOCK" means any and all shares, interests, rights to
     purchase, warrants, options, participations or other equivalents of or
     interests in (however designated) equity of the Company, including any
     preferred stock, but excluding any debt securities convertible into such
     equity prior to such conversion.

          "COMMON STOCK" means (i) prior to the Effective Time, the Old Common
     Stock, and (ii) at and after the Effective Time, the New Common Stock.

          "COMPANY" means the party named as such in the Preamble hereof until a
     successor replaces it pursuant to the applicable provision hereof and
     thereafter means the successor to such party.

          "DEFAULT" means any event which is, or after notice or passage of time
     or both would be, an Event of Default (as defined in Article XIII this
     Agreement).

          "DEPOSITARY AGREEMENT" means the Depositary Agreement dated as of the
     date hereof by and among the Company, the Lender and State Street Bank and
     Trust Company, as Depositary.

          "EFFECTIVE TIME" has the meaning set forth in the Merger Agreement.

          "EVENT OF DEFAULT" has the meaning set forth in Article XIII of this
     Agreement.

          "FINANCIAL STATEMENTS" has the meaning set forth in Section 3.7(a) of
     the Loan Agreement.

          "FIRST LOAN" has the meaning set forth in Section 2.3 of the Loan
     Agreement.

          "FIRST LOAN DATE" has the meaning set forth in Section 2.3 of the Loan
     Agreement.

          "GAAP" means U.S. generally accepted accounting principles as in
     effect from time to time.

          "INDEBTEDNESS" means and includes:

                    (a) all items which in accordance with GAAP would be
               included on the liability side of a balance sheet on the date as
               of which Indebtedness is to be determined (excluding capital
               stock, surplus reserves and deferred credits);

                    (b) all guaranties, letter of credit, contingent
               reimbursement obligations and other contingent obligations in
               respect of, or any obligations to purchase or otherwise acquire,
               indebtedness of others; and

                    (c) all indebtedness secured by any Lien existing on any
               interest of the Person with respect to which indebtedness is
               being determined in Property owned subject to such Lien whether
               or not the indebtedness secured thereby shall been assumed.

          "INVESTMENT" means the purchase or other acquisition of any
     Indebtedness of, or the making of any loan, advance or capital contribution
     to, or the incurring of any liability, contingent or otherwise, in respect
     of the Indebtedness of, any Person.

          "LENDER" means Alpharma USPD Inc., a Maryland corporation, the Lender
     under the Loan Agreement.

          "LIEN" means any mortgage, pledge, charge, encumbrance, security
     interest, collateral assignment or other lien or restriction of any kind,
     whether based on common law, constitutional provision, statute or contract,
     and shall include reservations, exceptions, encroachments, easements,
     rights of way, covenants, conditions, restrictions and other title
     exceptions.

          "LOAN" means any borrowing by the Company from the Lender of up to a
     maximum principal amount of $40,000,000 pursuant to Section 2.1 of the Loan
     Agreement and the other terms and conditions of the Loan Agreement.

          "LOAN AGREEMENT" has the meaning set forth in the Preamble to the
     Second Amendment.

          "MASTER AGREEMENT" has the meaning set forth in the Preamble to the
     Second Amendment.

          "MERGER AGREEMENT" has the meaning set forth in the Preamble to the
     Second Amendment.

          "MERGER SUBSIDIARY" has the meaning set forth in the Preamble to the
     Second Amendment.

          "NEW COMMON STOCK" has the meaning set forth in the Depositary
     Agreement.

          "OFFICER" means the Chairman of the Board, the President, any Vice
     President, the Treasurer or the Secretary of the Company.

          "OLD COMMON STOCK" has the meaning set forth in the Depositary
     Agreement.

          "OPTION CLOSING DATE" has the meaning set forth in the Depositary
     Agreement.

          "OPTION EXPIRATION DATE" has the meaning set forth in the Depositary
     Agreement.

          "PERMITTED INVESTMENTS" means:

                    (a) readily marketable securities issued or fully guaranteed
               by the United States of America with maturities of not more than
               one year;

                    (b) commercial paper rated "Prime 1" by Moody's Investors
               Services, Inc. or "A-1" by Standard and Poor's Rating Services
               with maturities of not more than 180 days;

                    (c) certificates of deposit or repurchase obligations issued
               by any bank organized under the laws of the United States of
               America or any state thereof having capital surplus of at least
               $100,000,000 or by any other financial institution acceptable to
               the Purchasers (and permitted assignees of the Purchasers) in
               accordance with Article XIV hereof, all of the foregoing not
               having a maturity of more than one year from the date of issuance
               thereof; and

                    (d) other Investments not exceeding, in the aggregate,
               $50,000 in any fiscal year.

          "PERMITTED LIENS" means each of the following:

                    (a) artisans' or mechanics' Liens arising in the ordinary
               course of business, and Liens for taxes, but only to the extent
               that payment thereof shall not at the time be due or if due, the
               payment thereof is being diligently contested in good faith and
               adequate reserves computed in accordance with GAAP have been set
               aside therefor;

                    (b) Liens in effect on the First Loan Date and disclosed to
               the Purchasers in the Financial Statements, provided that neither
               the Borrowed Money Indebtedness secured thereby nor the Property
               covered thereby shall increase after the First Loan Date without
               the prior written consent of the Purchasers (and permitted
               assignees of the Purchasers) in accordance with Article XIV
               hereof, provided that, for purposes of this clause (b), the
               accrual of interest on such Borrowed Money Indebtedness, so long
               as it is not converted to principal, shall not be deemed to
               increase such Borrowed Money Indebtedness;

                    (c) normal encumbrances and restrictions on title which do
               not secure Borrowed Money Indebtedness and which do not have a
               material adverse affect on the value or utility of the applicable
               Property;

                    (d) Liens incurred or deposits made in the ordinary course
               of business (i) in connection with workmen's compensation,
               unemployment insurance, social security and other like laws, or
               (ii) to secure insurance in the ordinary course of business, the
               performance of bids, tenders, contracts, leases, licenses,
               statutory obligations, surety, appeal and performance bonds and
               other similar obligations incurred in the ordinary course of
               business, but not, in any of the cases specified in this clause
               (ii), incurred in connection with the borrowing of money, the
               obtaining of advances or the payment of the deferred purchase of
               Property;

                    (e) Liens in connection with or to secure Borrowed Money
               Indebtedness permitted under Section 8.1(c) hereof;

                    (f) attachments, judgments and other similar Liens arising
               in connection with court proceedings, provided that the execution
               and enforcement of such Liens are effectively stayed and the
               claims secured thereby are being actively contested in good faith
               with adequate reserve made therefor in accordance with GAAP;

                    (g) Liens imposed by law, such as carriers', warehousemen's,
               mechanics', materialmen's and vendors' liens incurred in good
               faith in the ordinary course of business and securing obligations
               which are not yet due or which are being contested in good faith
               by appropriate proceedings if adequate reserves with respect
               thereto are maintained in accordance with GAAP;

                    (h) zoning restrictions, easements, licenses, reservations,
               provisions, covenants, conditions, waivers, and restrictions on
               the use of Property, and which do not in any case singly or in
               the aggregate materially impair the present use or value of
               Property subject to any such restriction or materially interfere
               with the ordinary conduct of the business of the Company and its
               Subsidiaries, if any;

                    (i) Liens securing purchase money Indebtedness permitted
               under Section 8.1 hereof and covering only the Property so
               purchased;

                    (j) capital leases and sale/leaseback transactions permitted
               under the other provisions of the Series G Purchase Agreement;
               and

                    (k) extensions, renewals and replacements of Liens referred
               to in paragraphs (a) through (j) of this definition; provided
               that any such extension, renewal or replacement Lien shall be
               limited to the Property or assets (and, in the case of clause
               (e), categories of Property or assets) covered by the Lien
               extended, renewed or replaced and that the Borrowed Money
               Indebtedness secured by any such extension, renewal or
               replacement Lien shall be in an amount not greater than the
               amount of the Indebtedness secured by the Lien extended, renewed
               or replaced.

          "PERSON" means any individual, corporation, association, company,
     business trust, partnership, joint venture, joint-stock company, limited
     liability company, trust, unincorporated organization or association or
     government or any agency or political subdivision thereof.

          "PROJECT" means (i) the acquisition of all or a substantial part of
     the stock or assets of any Person engaged in the development, manufacture
     or sale of pharmaceuticals or other health care products principally for
     the pediatric market; (ii) the acquisition of a product or product line
     from, or the acquisition of the right to manufacture, distribute or sell
     any product or product line of any Person, in each case with applications
     in the pediatric pharmaceutical health care market; or (iii) any R&D
     Project.

          "PROJECT LOANS" has the meaning set forth in Section 2.1of the Loan
     Agreement.

          "PROPERTY" means any interest in any kind of property or asset,
     whether real, personal or mixed, tangible or intangible.

          "R&D PROJECT" means any project for the research and development of
     products or processes related to pediatric pharmaceuticals

          "REGISTRATION RIGHTS AGREEMENT" has the meaning set forth in the
     Preamble to the Second Amendment.

          "SCREENED PROJECT" means a Project that meets the criteria set forth
     on Schedule II to the Loan Agreement.

          "SCREENED PROJECT LOANS" has the meaning set forth in Section 2.1 of
     the Loan Agreement.

          "SCREENED PROJECT INDEBTEDNESS" means Borrowed Money Indebtedness
     (other than Loans under the Loan Agreement) incurred for the purpose of
     funding a Screened Project.

          "SECOND AMENDMENT" means the Second Amendment dated February 16, 1999
     to the Securities Purchase Agreement date May 13, 1998 by and among Furman
     Selz Investors II L.P., FS Employee Investors LLC, FS Parallel Fund L.P.,
     BancBoston Ventures Inc., Flynn Partners and the Company.

          "SUBSIDIARY" of a Person means any corporation, association,
     partnership, joint venture or other business entity of which more than
     fifty percent (50%) of the voting stock or other equity interests (in the
     case of Persons other than corporations), is owned or controlled directly
     or indirectly by the Person, or one or more of the Subsidiaries of the
     Person, or a combination thereof.

          "UNRESTRICTED LOANS" means one or more Loans made on or after the
     Alpharma Closing Date in an aggregate principal amount not to exceed
     $8,000,000."

          SECTION 3.9 AMENDMENT TO SECTION 10.2. Section 10.2 of the Series G
Purchase Agreement is amended by deleting the definition of "Registrable Warrant
Shares" included thereon and inserting in lieu thereof the following:

               ""REGISTRABLE WARRANT SHARES" shall mean the Warrant Shares and
          the Direct Purchase Shares and any other securities issued in respect
          of the Warrant Shares or the Direct Purchase Shares upon any stock
          split, stock dividend, recapitalization, merger, consolidation or
          similar event, provided, however, that shares of Common Stock which
          are Registrable Warrant Shares shall cease to be Registrable Warrant
          Shares upon any sale pursuant to a Registration Statement, Section
          4(1) of the Securities Act or Rule 144 under the Securities Act, or
          any sale in any manner to a person or entity which, by virtue of
          Section 17.3 of this Agreement is not entitled to the rights provided
          by this Article X or at such time as the Holder of such shares may
          sell under Rule 144 under the Securities Act in a three-month period
          all Registrable Securities then held by such Holder. For purposes of
          this definition, Direct Purchase Shares shall have the meaning
          ascribed to such term in the Second Amendment, as such term is defined
          in Section 8.15."

         SECTION 3.10 AMENDMENT TO ARTICLE XI. Article XI of the Series G
Purchase Agreement is amended by adding thereto the following:

               "11.9 SENIOR INDEBTEDNESS UNDER THE ALPHARMA LOAN. If any
          indebtedness of the Company would constitute both "Senior
          Indebtedness" as defined in Section 11.1 and "Senior Indebtedness" as
          defined in the Loan Agreement, as such term is defined in Section
          8.15, the terms of subordination of the Notes relating to such
          indebtedness shall be as set forth in the Subordination Agreement
          dated as of February 16, 1999 among the Company, the Purchasers and
          Alpharma USPD, Inc., a Maryland corporation without reference to this
          Article XI."

         SECTION 3.11 AMENDMENT TO SECTION 12.11. Section 12.11 of the Series G
Purchase Agreement is amended by deleting in its entirety the second sentence of
the first paragraph thereof and inserting in lieu thereof the following:

               "Notwithstanding any additional or contrary rights of the
          Purchasers contained in Section 9.3 hereof, the Convertible Notes
          shall be automatically converted into shares of Common Stock at the
          applicable Conversion Price in accordance with this Article XII
          immediately prior to the Option Closing on the Option Closing Date, as
          such terms are defined in the Depository Agreement (as such term is
          defined in Section 8.15). The date on which either of the foregoing
          conditions is first satisfied is hereinafter referred to as the
          "Mandatory Conversion Date""

         SECTION 3.12 AMENDMENT TO SECTION 13.1. Section 13.1 of the Series G
Purchase Agreement is amended by deleting the text thereof and inserting in lieu
thereof the following:

               "13.1 EVENTS OF DEFAULT. An "Event of Default" occurs if:

               (a)  the Company defaults in the payment of interest on any Note
                    when the same becomes due and payable and such default
                    continues for a period of 5 Business Days;

               (b)  the Company defaults in the payment of the principal of any
                    Note when the same becomes due and payable at maturity, upon
                    acceleration or otherwise;

               (c)  the Company defaults in the performance of any covenants
                    under Article VIII of this Agreement;

               (d)  the Company fails to comply with any of the provisions of
                    this Agreement (other than Article VIII) and such failure
                    continues for 20 Business Days after notice specified in the
                    penultimate paragraph of this Section 13.1 (the "Default
                    Notice") without cure (the Company to give forthwith to all
                    other holders of the Notes at the time outstanding written
                    notice of the receipt of such Default Notice, specifying the
                    default referred to therein); or

               (e)  the Company defaults in payment on Borrowed Money
                    Indebtedness (giving effect to any applicable grace periods
                    and any extensions thereof) of at least $700,000 principal
                    amount;

               (f)  there has been an acceleration of the final stated maturity
                    of any Borrowed Money Indebtedness of the Company (which
                    acceleration shall not have been cured, waived, rescinded or
                    annulled for 10 Business Days) if the aggregate principal
                    amount of such Borrowed Money Indebtedness, together with
                    the principal amount of any other such Borrowed Money
                    Indebtedness in default for failure to pay principal at
                    maturity or which has been accelerated, aggregates $700,000
                    or more at any time;

               (g)  any representation or warranty of the Company under this
                    Agreement shall prove to have been incorrect in any material
                    respect when made;

               (h)  there exists an outstanding unsatisfied final judgment
                    which, either alone or together with other outstanding
                    unsatisfied final judgments against the Company, exceeds an
                    aggregate of $200,000 (to the extent not covered by
                    insurance) and such judgment shall have continued
                    undischarged or unstayed for 20 Business Days after entry
                    thereof;

               (i)  the Company pursuant to or within the meaning of any
                    Bankruptcy Law:

                    (i)      commenced a voluntary case,

                    (ii)     consents to the entry of an order for relief 
                             against it in an involuntary case,

                    (iii)    consents to the appointment of a custodian of it 
                             or for all or substantially all of its property, or

                    (iv)     makes a general assignment for the benefit of its 
                             creditors; or

               (j)  a court of competent jurisdiction enters an order or decree
                    under any Bankruptcy Law that:

                    (i)      is for relief against the Company in an 
                             involuntary case,

                    (ii)     appoints a custodian of the Company for all or 
                             substantially all of its property, or

                    (iii)    orders the liquidation of the Company,
                             and the order or decree remains unstayed and
                             in effect for 90 consecutive days.

         A default under paragraph (d) of this Section 13.1 is not a default
         unless the holders of at least eighty percent (80%) of the aggregate
         principal amount then outstanding under the Notes notify the Company of
         the default and the Company does not cure the default within twenty
         (20) days after receipt of such notice. The notice must specify the
         default and demand that it be remedied.

         A "Business Day" means any day which is neither a Saturday nor a Sunday
         nor a legal holiday on which banks are authorized or required to close
         in Boston, Massachusetts or New York, New York. A "Default" means any
         of the events specified in this Section 13.1, regardless of whether
         there shall have occurred any passage of time or giving of notice or
         both that would be necessary in order to constitute such event an Event
         of Default."

          SECTION 3.13 EFFECTIVENESS OF AMENDMENTS.

          (a) The amendments to the Series G Purchase Agreement set forth in
this Article III shall be effective on and after the Second Amendment Closing
Date.

          (b) If the average closing price of the Common Stock is not greater
than $12.00 per share as traded on the Nasdaq Stock Market or a registered
national securities exchange over the 60 trading days prior to the Option
Expiration Date, as such term is defined in the Depositary Agreement, then the
amendments to the Series G Purchase Agreement set forth in this Article III
shall cease to be effective, and the terms of the Series G Purchase Agreement
amended hereby shall be as if such amendments had never been made, as of the
Option Expiration Date; provided, however, that (i) Section 7.5 (a) of the
Series G Purchase Agreement shall be amended by deleting the word "nine" in the
first sentence thereof and inserting in lieu thereof the word "ten" and (ii) the
Amendment to Article XI set forth in Section 3.10 of this Second Amendment shall
remain in effect so long as the Subordination Agreement dated as of February 16,
1999 among the Company, the Purchasers and Alpharma remains in effect. In such
event, any Default or Event of Default due to the existence of circumstances
which would not have constituted a Default or Event of Default immediately prior
to the Option Expiration Date are hereby waived.

                                   ARTICLE IV
                              AMENDMENT TO WARRANTS

          SECTION 4.1 AMENDMENT TO THE DEFINITION OF "WARRANT PRICE" IN THE
WARRANTS. The definition of "Warrant Price" in Section 1.1(m) of each
outstanding Warrant is amended by deleting the phrase "four dollars and seventy
five cents ($4.75)" and inserting in lieu thereof the phrase "three dollars
($3.00)."

          SECTION 4.2 EFFECTIVENESS OF THE AMENDMENT. The amendment to the
Warrants set forth in this Article IV shall be effective on and after the Second
Amendment Closing Date.

                                    ARTICLE V
        AUTHORIZATION AND SALE AND PURCHASE OF THE DIRECT PURCHASE SHARES

          SECTION 5.1 AUTHORIZATION OF THE DIRECT PURCHASE SHARES. The Company
has, or before the Second Amendment Closing Date will have, authorized the
issuance and sale of 300,000 shares of Common Stock (the "Direct Purchase
Shares").

          SECTION 5.2 SALE AND PURCHASE OF THE DIRECT PURCHASE SHARES. Subject
to the terms and conditions hereof and in reliance on the representations and
warranties contained herein, the Company will issue and sell to each Purchaser,
and such Purchaser will purchase from the Company, on the Second Amendment
Closing Date (as defined below), the number of Direct Purchase Shares set forth
opposite the name of such Purchaser on Schedule 1 attached hereto, for a
purchase price per share of Direct Purchase Shares of $3.00, with the aggregate
purchase price for all the Direct Purchase Shares being $900,000.

          SECTION 5.3 CLOSING. The closing of the purchase and sale of the
Direct Purchase Shares (the "Second Amendment Closing") will take place at the
offices of Hale and Dorr LLP, 60 State Street, Boston, Massachusetts 02109 at
1:00 p.m., local time, on the Alpharma Closing Date or such other time and date,
or place as shall be mutually agreed to by the Company and FS Private
Investments LLC, on behalf of the Purchasers. Such time and date are hereinafter
referred to as the "Second Amendment Closing Date." If the Second Amendment
Closing shall not have occurred on or before September 30, 1999, this Second
Amendment shall automatically terminate.

          At the Second Amendment Closing, the Company will deliver to each
Purchaser a certificate or certificates (in definitive form) in the
denominations specified in Schedule 1 and registered in the name of such
Purchaser (or in the name of such Purchaser's nominee) representing the Direct
Purchase Shares to be purchased by such Purchaser against payment to the Company
of the purchase price of such Direct Purchase Shares, by delivery to the Company
of Subordinated Notes in an aggregate principal amount equal to the purchase
price to be paid by each Purchaser. Accrued interest on the Subordinated Notes
so delivered shall be paid to the Purchasers on the Second Amendment Closing
Date.


                                   ARTICLE VI
                           EXCHANGE OF PREFERRED STOCK
                            AND EXERCISE OF WARRANTS

          SECTION 6.1 EXCHANGE OF PREFERRED STOCK. Pursuant to the terms of the
Preferred Stock, the Company shall exchange all outstanding shares of the
Preferred Stock for Convertible Notes on the Second Amendment Closing Date. The
Exchange Date, as defined in the Certificate of Designation shall be the Second
Amendment Closing Date.

          SECTION 6.2 EXERCISE OF WARRANTS. Pursuant to the terms of the
Warrants, each Purchaser agrees to exercise all Warrants held by such Purchaser
on the Second Amendment Closing Date. The Warrant Price, as such term is defined
in the Warrants, shall be paid by delivery to the Company of Subordinated Notes
in an aggregate principal amount equal to the Warrant Price to be paid by each
Purchaser. Accrued interest on the Subordinated Notes so delivered shall be paid
to the Purchasers on the Second Amendment Closing Date.

                                   ARTICLE VII
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

          The Company represents and warrants to the Purchasers as follows:

          SECTION 7.1 ORGANIZATION AND EXISTENCE, ETC. The Company (a) is duly
incorporated, validly existing and in good standing under the laws of the State
of Delaware, and has all requisite power and authority to carry on its business
as now conducted and as proposed to be conducted, and (b) is duly qualified to
do business as a foreign corporation and is in good standing (or the equivalent
thereof under applicable law) in each jurisdiction in which the conduct of its
business requires such qualification by reason of the ownership or leasing of
property or otherwise (except for those jurisdictions in which the failure so to
qualify does not have a Material Adverse Effect). "Material Adverse Effect"
means, when used in connection with the Company, any development, change or
effect that is materially adverse to the business, properties, assets, net
worth, financial condition, results of operations or future prospects (including
without limitation, future equity value) of the Company and its Subsidiaries
taken as a whole.

          SECTION 7.2 CAPITALIZATION OF THE COMPANY.

          (a) As of the date hereof, (i) the Company's authorized capital stock
consists of: 60,000,000 shares of Common Stock, of which 7,026,445 shares are
validly issued and outstanding, fully paid and non-assessable, and 5,000,000
shares of "blank check" preferred stock, $.01 par value per share, of which
7,000 shares have been designated Series G Convertible Exchangeable Preferred
Stock, all of which shares are validly issued and outstanding, fully paid and
non-assessable; and (ii) the Company has outstanding the securities set forth on
Schedule 7.2 attached hereto which are convertible into or exercisable or
exchangeable for Common Stock (the "Derivative Securities").

          (b) All the issued and outstanding shares of capital stock of the
Company are free of preemptive and similar rights and have been offered, issued,
sold and delivered by the Company in transactions in compliance with the
applicable federal, state and foreign securities laws. Other than as set forth
in Schedule 7.2 attached hereto, there are no outstanding agreements or
commitments requiring the Company to issue capital stock or Derivative
Securities as of the date hereof.

          SECTION 7.3 AUTHORIZATION; BINDING OBLIGATIONS.

          (a) The Company has full power and authority to execute and deliver
this Second Amendment and such other documents furnished or to be furnished by
the Company hereunder, subject to the approval by the stockholders of the
Company of this Second Amendment and the transactions contemplated hereby. This
Second Amendment, subject to the approval by the stockholders of the Company of
this Second Amendment and the transactions contemplated hereby, has been duly
authorized, executed and delivered by the Company and, subject to the approval
by the stockholders of the Company of this Second Amendment and the transactions
contemplated hereby, constitutes a legal, valid and binding agreement of the
Company, enforceable against the Company in accordance with its terms, subject
to bankruptcy, insolvency, reorganization and other laws of general
applicability relating to or affecting creditors' rights and to general
principles of equity. Subject to the approval by the stockholders of the Company
of this Second Amendment and the transactions contemplated hereby, the issuance,
offering and sale of the Direct Purchase Shares pursuant to this Second
Amendment, the compliance by the Company with the provisions of this Second
Amendment, and the consummation of the other transactions herein contemplated
will not result in the creation or imposition of any lien, charge, security
interest or encumbrance upon any of the assets of the Company pursuant to the
terms or provisions of, or result in a breach or violation of or conflict with
any of the terms or provisions of, or constitute a default under, or give any
other party a right to terminate any of its obligations under, or result in the
acceleration of any obligation under, (i) the Certificate of Incorporation and
Bylaws of the Company, (ii) any contract or other agreement to which the Company
is a party or by which the Company or any of its respective properties is bound
or (iii) any judgment, ruling, decree, order, statute, rule or regulation of any
court or other governmental agency or body, domestic or foreign, applicable to
the business or properties of the Company, except, with respect to clauses (ii)
and (iii), circumstances that would not, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect.

          (b) Subject to the approval by the stockholders of the Company of this
Second Amendment and the transactions contemplated hereby, the Direct Purchase
Shares have been duly authorized for issuance and, when issued and delivered in
accordance with the provisions of this Second Amendment, will be validly issued,
fully paid and nonassessable.

          SECTION 7.4 COMPLIANCE WITH INSTRUMENTS, ETC. Except as set forth on
Schedule 7.4 hereto, the Company is not in breach or violation of, or in default
under, any term or provision of (i) its Certificate of Incorporation and Bylaws,
(ii) any indenture, mortgage, deed of trust, voting trust agreement,
stockholders agreement, note agreement, debt instrument or other agreement or
instrument to which it is a party or by which it is bound or to which any of its
property is subject, the effect of which breach, violation or default,
individually or in the aggregate, would reasonably be expected to have a
Material Adverse Effect, or (iii) any statute, judgment, decree, order, rule or
regulation applicable to the Company or of any arbitrator, court, regulatory
body, administrative agency or any other governmental agency or body, domestic
or foreign, having jurisdiction over the Company or any of its respective
activities or properties and the effect of which breach, violation or default,
individually or in the aggregate, would reasonably be expected to have a
Material Adverse Effect.

          SECTION 7.5 LITIGATION. Except as set forth on Schedule 7.5 hereto,
there are no actions, suits, proceedings or investigations pending, or, to the
knowledge of the Company, threatened, against the Company before or by any
court, regulatory body or administrative agency or any other governmental agency
or body, domestic or foreign, which would, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect, or any actions, suits,
proceedings or investigations pending, or, to the knowledge of the Company,
threatened, which challenges the validity of any action taken or to be taken
pursuant to or in connection with this Second Amendment or the issuance of the
Direct Purchase Shares which would, individually or in the aggregate, reasonably
be expected to have a Material Adverse Effect. As it pertains to the Company,
when used herein, the phrases "to the knowledge of" or derivatives thereof shall
mean the actual knowledge of the Chief Executive Officer or Vice President,
Finance of the Company.

          SECTION 7.6 OFFERING. Subject to the Purchasers' representations and
warranties in Article VIII of this Second Amendment, the offer, sale and
issuance of the Direct Purchase Shares as contemplated by this Second Amendment
are not subject to the registration requirements of the Securities Act of 1933,
as amended (the "Securities Act") and neither the Company nor anyone acting on
its behalf, has taken or will take any action that would cause such registration
requirements to be applicable.

          SECTION 7.7 PERMITS; GOVERNMENTAL AND OTHER APPROVALS. No approval,
consent, authorization or other order of, and no designation, filing,
registration, qualification or recording with, any governmental authority,
domestic or foreign, is required for the Company's performance of this Second
Amendment or the consummation of the transactions contemplated hereby except for
applicable filings with the Nasdaq Stock Market, the filing of a Form D under
the Securities Act and the filing of a Form 8-K under the Securities Exchange
Act of 1934, as amended (the "Exchange Act").

                                  ARTICLE VIII
                REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS

          Each Purchaser, severally and not jointly, hereby represents and
warrants to the Company that (i) it is an "accredited investor" as that term is
defined in Rule 501(a) promulgated under the Securities Act, (ii) it has the
requisite knowledge and experience in financial and business matters to be
capable of evaluating the merits and risks of an investment in the Company,
(iii) it has had an opportunity to discuss the Company's business, management
and financial affairs with the Company's management, (iv) it is acquiring the
Direct Purchase Shares for investment for its own account and not with a view
to, or for resale in connection with, any distribution thereof; nor with any
present intention of distributing or selling the same; and, except as
contemplated by the Series G Purchase Agreement, such Purchaser has no present
or contemplated agreement, undertaking, arrangement, obligation, indebtedness or
commitment providing for the disposition thereof, (v) it is not in material
breach or violation of, or in default under, any term or provision of (A) its
organizational and governing documents, (B) any indenture, mortgage, deed of
trust, voting trust agreement, stockholders, partners or members agreement, note
agreement or other agreement or instrument to which it is a party or by which it
is or may be bound or to which any of its property is or may be subject, or (C)
any statute, judgment, decree, order, rule or regulation applicable to such
Purchaser or of any arbitrator, court, regulatory body, administrative agency or
any other governmental agency or body, domestic or foreign, having jurisdiction
over such Purchaser or any of its activities or properties, (vi) any Purchaser
which is a corporation, partnership, limited liability company or trust
represents that it has not been organized, reorganized or recapitalized
specifically for the purpose of investing in the Company, (vii) it understands
that the Direct Purchase Shares have not been registered under the Securities
Act and it will not offer, sell, transfer, pledge, hypothecate or otherwise
dispose of any Direct Purchase Shares except pursuant to an exemption from, or
otherwise in a transaction not subject to, the registration requirements of the
Securities Act or pursuant to an effective registration statement under the
Securities Act, and, in each case, in accordance with any applicable state
securities or "blue sky" laws and (viii) it understands that any certificates
representing the Shares and any other securities issued in respect of such
securities upon any stock split, stock dividend, recapitalization, merger,
consolidation or similar event, shall be stamped or otherwise imprinted with a
legend in the following form (in addition to any legend required under other
applicable securities laws):

               "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
               UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE
               'ACT'), OR ANY STATE SECURITIES LAWS AND MAY NOT BE
               TRANSFERRED, SOLD OR OFFERED FOR SALE EXCEPT PURSUANT
               TO AN EFFECTIVE REGISTRATION STATEMENT AS TO THE
               SECURITIES UNDER THE ACT AND ANY APPLICABLE STATE
               SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY
               SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS
               NOT REQUIRED."

Each Purchaser further represents that (i) it has full power and authority to
execute, deliver and perform this Second Amendment, (ii) the person executing
this Second Amendment on behalf of such Purchaser has the appropriate authority
to act on behalf of such Purchaser, and (iii) this Second Amendment has been
duly authorized, executed and delivered by such Purchaser and constitutes a
legal, valid and binding agreement of such Purchaser, enforceable against such
Purchaser in accordance with its terms, subject to bankruptcy, insolvency,
reorganization and other laws of general applicability relating to or affecting
creditors' rights and to general principles of equity, and (iv) it has not
employed any broker or finder in connection with the transactions contemplated
by this Second Amendment. To the best of its knowledge, each Purchaser
acknowledges receipt of, and the opportunity to review, the information that it
believes necessary to make an investment in the Direct Purchase Shares.

                                   ARTICLE IX
                   CONDITIONS OF OBLIGATIONS OF THE PURCHASERS

          The obligations of each of the Purchasers under this Second Amendment
are subject to the fulfillment to their reasonable satisfaction, or the waiver
by the Purchasers, on or prior to the Second Amendment Closing Date of each of
the following conditions:

          SECTION 9.1 REPRESENTATIONS AND WARRANTIES CORRECT. The
representations and warranties of the Company in Article VII hereof shall be
true and correct on and as of the date hereof, and shall be true and correct in
all material respects on and as of the Second Amendment Closing Date with the
same force and effect as if they had been made on and as of the Second Amendment
Closing Date.

          SECTION 9.2 PERFORMANCE. All covenants, agreements and conditions
contained in this Second Amendment to be performed or complied with on or prior
to the Second Amendment Closing Date by the Company shall have been performed or
complied with by the Company in all material respects on or prior to the Second
Amendment Closing Date.

          SECTION 9.3 COMPLIANCE CERTIFICATE. The Company shall have delivered
to the Purchasers a certificate of the Company's President, dated the Second
Amendment Closing Date, certifying to the fulfillment of the conditions
specified in Sections 9.1, 9.2 and 9.5 of this Second Amendment and such other
matters as the Purchasers shall reasonably request.

          SECTION 9.4 NO IMPEDIMENTS. No statute, judgment, order, decree of any
court, regulatory body, administrative agency or any other governmental agency
or body shall be in effect which would impose any material limitation on the
ability of the Purchasers to exercise full rights of ownership of the Direct
Purchase Shares.

          SECTION 9.5 NO MATERIAL ADVERSE CHANGE. Except as set forth in the
Schedules attached to the Loan Agreement pursuant to Article III thereof, as
disclosed in the 1934 Act Filings (as defined in the Loan Agreement) filed with
the SEC prior to the date of the Master Agreement or as set forth in Schedule
4.1(e) to the Loan Agreement, since September 30, 1998, there shall have been no
Material Adverse Effect with respect to the Company (other than the continued
incurrence of losses in the ordinary course of business).

          SECTION 9.6 LEGAL INVESTMENT. The purchase of the Direct Purchase
Shares by the Purchasers hereunder shall be legally permitted by all statutes,
rules and regulations to which the Purchasers and the Company are subject.

          SECTION 9.7 QUALIFICATIONS. All authorizations, approvals or permits,
if any, of any governmental authority or regulatory body that are now required
in connection with the lawful issuance and sale of the Direct Purchase Shares
pursuant to this Second Amendment shall have been duly obtained and shall be in
full force and effect on and as of the Second Amendment Closing Date.

          SECTION 9.8 PROCEEDINGS AND OTHER DOCUMENTS. All corporate and other
proceedings in connection with the transactions contemplated by this Second
Amendment shall have been taken and the Purchasers shall have received such
other documents and instruments in form and substance reasonably satisfactory to
them and their counsel, as to such other matters incident to the transaction
contemplated hereby as they may reasonably request.

          SECTION 9.9 OPINION OF COUNSEL. The Purchasers shall have received the
opinion of Hale and Dorr LLP, counsel for the Company, dated the Second
Amendment Closing Date, substantially in the form delivered in connection with
the original issuance of the Securities, but limited to matters relating to the
Second Amendment and the Direct Purchase Shares.

          SECTION 9.10 OTHER MATTERS. The Company shall have delivered to the
Purchasers certificates (in definitive form) in the denominations specified by
the respective Purchasers and registered in their respective names (or in the
names of their respective nominees) representing the Direct Purchase Shares.


                                    ARTICLE X
                    CONDITIONS OF OBLIGATIONS OF THE COMPANY

          The Company's obligations under this Second Amendment are subject to
the fulfillment to its reasonable satisfaction, or the waiver by the Company, on
or prior to the Second Amendment Closing Date of each of the following
conditions:

          SECTION 10.1 REPRESENTATIONS AND WARRANTIES CORRECT. The
representations and warranties of the Purchasers in Article VIII hereof shall be
true and correct on and as of the date hereof and shall be true and correct in
all material respects on and as of the Second Amendment Closing Date with the
same force and effect as if they had been made on and as of the Second Amendment
Closing Date.

          SECTION 10.2 LEGAL INVESTMENT. The purchase of the Direct Purchase
Shares by the Purchasers hereunder shall be legally permitted by all statutes,
rules and regulations to which the Purchasers and the Company are subject.

          SECTION 10.3 STOCKHOLDER APPROVAL. The stockholders of the Company
shall have approved this Second Amendment and the transactions contemplated
hereby.

          SECTION 10.4 PAYMENT OF PURCHASE PRICE. The Company shall have
received payment in full of the aggregate purchase price required to be paid
under Article V.

<PAGE>

                                   ARTICLE XI
                                  MISCELLANEOUS

          SECTION 11.1 THE SERIES G PURCHASE AGREEMENT. Except as amended by
this Second Amendment, the Series G Purchase Agreement shall remain in full
force and effect in accordance with its terms. This Second Amendment shall be
deemed to be part of the Series G Purchase Agreement.

          SECTION 11.2 GOVERNING LAW. The rights and obligations of the parties
under or pursuant to this Second Amendment shall be governed by and construed in
accordance with the laws of the State of New York.

          SECTION 11.3 REPRESENTATION AND WARRANTY. Each party hereto hereby
represents and warrants that this Second Amendment is a legal, valid and binding
obligation of such party and is enforceable against such party in accordance
with its terms.

          SECTION 11.4 REFERENCES TO SERIES G PURCHASE AGREEMENT. Whenever in
any certificate, letter, notice or other instrument reference is made to the
Series G Purchase Agreement, such reference without more shall include this
Second Amendment.

          SECTION 11.5 AMENDMENTS TO ALPHARMA AGREEMENTS.

          (a) No amendment to the Loan Agreement or any of the Ancillary
Agreements shall have the effect of changing the meaning of any provision of
this Second Amendment or the Series G Purchase Agreement without the consent of
the Purchasers (and permitted assignees of the Purchasers) in accordance with
Article XIV of the Series G Purchase Agreement.

          (b) The Company shall not consent to any amendment to the proviso to
the definition of "Option Exercise Price" in the Depositary Agreement without
the consent of the Purchasers (and permitted assignees of the Purchasers) in
accordance with Article XIV of the Series G Purchase Agreement.

          SECTION 11.6 COUNTERPARTS. This Second Amendment may be executed
simultaneously in counterparts, each of which shall be deemed an original, and
it shall not be necessary in making proof of the contents of this Second
Amendment to produce or account for more than one such counterpart.

<PAGE>

          IN WITNESS WHEREOF this Second Amendment has been executed by duly
authorized representatives of the parties hereto on the day, month and year
first above written.


                                      ASCENT PEDIATRICS, INC.


                                      By: /s/ ALAN R. FOX
                                          Name:  Alan R. Fox
                                          Title: President


                                      FURMAN SELZ INVESTORS II L.P.
                                      FS EMPLOYEE INVESTORS LLC
                                                     FS PARALLEL FUND L.P.

                                      By:  FS PRIVATE INVESTMENTS LLC,
                                             MANAGER


                                      By: /s/ JAMES L. LUIKART 
                                          Name:  James L. Luikart
                                          Title: Managing Member


                                      BANCBOSTON VENTURES INC.


                                      By: /s/ MARCIA T. BATES 
                                          Name:   Marcia T. Bates
                                          Title:  Managing Director


                                      FLYNN PARTNERS


                                       By: /s/ JAMES E. FLYNN 
                                           Name: James E. Flynn, General Partner
                                                 Flynn Partners


<PAGE>

                                   Schedule 1

                                   Purchasers


                                NUMBER OF DIRECT PURCHASE     AGGREGATE PURCHASE
NAME OF PURCHASER                SHARES TO BE PURCHASED:          PRICE
- --------------------------------------------------------------------------------

Furman Selz Investors II L.P.        198,350                     $595,050

FS Employee Investors LLC             17,000                     $51,000

FS Parallel Fund L.P.                  9,650                      28,950

BancBoston Ventures Inc.              71,250                     213,750

Flynn Partners                         3,750                     $11,250
                                    ------------
                        Total        300,000                     $900,000

                                                                 EXHIBIT C



February 16, 1999

Ascent Pediatrics, Inc.
187 Ballardvale Street, Suite B125
Wilmington, MA  01887


Ladies and Gentlemen:

          The purpose of this letter (this "Amendment") is to amend the
financial advisory services fee arrangements set forth in the letter (the
"Initial Letter") among FS Private Investments LLC ("Furman Selz"), BancBoston
Ventures Inc. ("BancBoston") and Ascent Pediatrics, Inc. (together with any
successor thereto, the "Company"), which confirmed such parties agreement and
understanding with respect to certain arrangements among such parties in
connection with the $16,000,000 investment by certain investment partnerships
managed by Furman Selz, BancBoston and another investor (collectively, the
"Purchasers") in the Series G Convertible Exchangeable Preferred Stock,
Subordinated Notes and Warrants of the Company (the "Financing").

          This Amendment shall be effective on the Second Amendment Closing Date
(as such term is defined in the Second Amendment dated February 16, 1999 to the
Securities Purchase Agreement dated May 13, 1998 by and among Furman Selz
Investors II L.P., FS Employee Investors LLC, FS Parallel Fund L.P., BancBoston
Ventures Inc., Flynn Partners and Ascent Pediatrics, Inc., as amended (such
Securities Purchase Agreement as so and heretofore amended, the "Purchase
Agreement").

          Pursuant to this Amendment, Furman Selz and the Company agree as
follows:

               1. FEE ARRANGEMENTS. Prior to the Second Amendment Closing Date,
the financial advisory services fee arrangements shall be as set forth in the
Initial Letter. On the Second Amendment Closing Date, in lieu of any additional
cash fees required to be paid to Furman Selz pursuant to the Initial Letter for
such services, the Company shall issue to Furman Selz 150,000 unregistered
shares (the "Shares") of the Company's common stock, par value $.00004 per share
(the "Common Stock"). The aggregate dollar value of the Shares is $525,000.

               2. REGISTRATION RIGHTS. The Company hereby grants the
registration rights to Furman Selz which were granted pursuant to Article X of
the Purchase Agreement. Under such Article X, Furman Selz shall be deemed to be
a "Holder" (as defined therein) for all purposes and the Shares shall be deemed
to be Registrable Securities (as defined therein) for all purposes. In addition,
for purposes of Section 10.3 thereof, at the election of Furman Selz, the Shares
shall also be deemed to be either Registrable Conversion Shares or Registrable
Warrant Shares (both as defined therein). This paragraph 2 shall be an amendment
to Article X of the Purchase Agreement.

               3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company
hereby represents and warrants to Furman Selz as follows:

               (i)  The Company has full power and authority to execute and
                    deliver this Amendment and issue the Shares and to execute
                    and deliver such other documents furnished or to be
                    furnished by the Company hereunder, subject to the approval
                    of the stockholders of the Company of this Amendment and the
                    transactions contemplated hereby. This Amendment, subject to
                    the approval of the stockholders of the Company of this
                    Amendment and the transactions contemplated hereby, has been
                    duly authorized, executed and delivered by the Company and,
                    subject to the approval of the stockholders of the Company
                    of this Amendment and the transactions contemplated hereby,
                    constitutes a legal, valid and binding agreement of the
                    Company, enforceable against the Company in accordance with
                    its terms, subject to bankruptcy, insolvency, reorganization
                    and other laws of general applicability relating to or
                    affecting creditors' rights and to general principles of
                    equity. Subject to the approval of the stockholders of the
                    Company of this Amendment and the transactions contemplated
                    hereby, the issuance of the Shares pursuant to this
                    Amendment, the compliance by the Company with the provisions
                    of this Amendment, and the consummation of the other
                    transactions herein contemplated will not result in the
                    creation or imposition of any lien, charge, security
                    interest or encumbrance upon any of the assets of the
                    Company pursuant to the terms or provisions of, or result in
                    a breach or violation of or conflict with any of the terms
                    or provisions of, or constitute a default under, or give any
                    other party a right to terminate any of its obligations
                    under, or result in the acceleration of any obligation
                    under, (i) the Certificate of Incorporation and Bylaws of
                    the Company, or (ii) any contract or other agreement to
                    which the Company is a party or by which the Company or any
                    of its respective properties is bound, or (iii) any
                    judgment, ruling, decree, order, statute, rule or regulation
                    of any court or other governmental agency or body, domestic
                    or foreign, applicable to the business or properties of the
                    Company, except, with respect to clauses (ii) and (iii),
                    circumstances that would not, individually or in the
                    aggregate, reasonably be expected to have a material adverse
                    effect on the Company.

               (ii) Subject to the approval of the stockholders of the Company
                    of this Amendment and the transactions contemplated hereby,
                    the Shares have been duly authorized for issuance hereby,
                    and, when issued and delivered in accordance with the
                    provisions of this Amendment, will be validly issued, fully
                    paid and nonassessable.


<PAGE>
               4. REPRESENTATIONS AND WARRANTIES OF FURMAN SELZ. Furman Selz
hereby represents and warrants to the Company that (i) it is an "accredited
investor" as that term is defined in Rule 501(a) promulgated under the
Securities Act of 1933, as amended, (ii) it has the requisite knowledge and
experience in financial and business matters to be capable of evaluating the
merits and risks of an investment in the Company, (iii) it has had an
opportunity to discuss the Company's business, management and financial affairs
with the Company's management, (iv) it is acquiring the Shares for investment
for its own account and not with a view to, or for resale in connection with,
any distribution thereof; nor with any present intention of distributing or
selling the same; and Furman Selz has no present or contemplated agreement,
undertaking, arrangement, obligation, indebtedness or commitment providing for
the disposition thereof, (v) it is not in material breach or violation of, or in
default under, any term or provision of (A) its organizational and governing
documents, (B) any indenture, mortgage, deed of trust, voting trust agreement,
stockholders, partners or members agreement, note agreement or other agreement
or instrument to which it is a party or by which it is bound or to which any of
its property is subject, or (C) any statute, judgment, decree, order, rule or
regulation applicable to Furman Selz or of any arbitrator, court, regulatory
body, administrative agency or any other governmental agency or body, domestic
or foreign, having jurisdiction over Furman Selz or any of its activities or
properties, (vi) Furman Selz represents that it has not been organized,
reorganized or recapitalized specifically for the purpose of investing in the
Company, (vii) it understands that the Shares have not been registered under the
Securities Act and it will not offer, sell, transfer, pledge, hypothecate or
otherwise dispose of any Shares except pursuant to an exemption from, or
otherwise in a transaction not subject to, the registration requirements of the
Securities Act or pursuant to an effective registration statement under the
Securities Act, and, in each case, in accordance with any applicable state
securities or "blue sky" laws and (viii) it understands that any certificates
representing the Shares and any other securities issued in respect of such
securities upon any stock split, stock dividend, recapitalization, merger,
consolidation or similar event, shall be stamped or otherwise imprinted with a
legend in the following form (in addition to any legend required under other
applicable securities laws):

               "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
               UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE
               'ACT'), OR ANY STATE SECURITIES LAWS AND MAY NOT BE
               TRANSFERRED, SOLD OR OFFERED FOR SALE EXCEPT PURSUANT
               TO AN EFFECTIVE REGISTRATION STATEMENT AS TO THE
               SECURITIES UNDER THE ACT AND ANY APPLICABLE STATE
               SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY
               SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS
               NOT REQUIRED."

               Furman Selz further represents that (i) it has full power and
authority to execute, deliver and perform this Amendment, (ii) the person
executing this Amendment on behalf of Furman Selz has the appropriate authority
to act on behalf of Furman Selz, and (iii) this Amendment has been duly
authorized, executed and delivered by Furman Selz and constitutes a legal, valid
and binding agreement of Furman Selz, enforceable against Furman Selz in
accordance with its terms, subject to bankruptcy, insolvency, reorganization and
other laws of general applicability relating to or affecting creditors' rights
and to general principles of equity, and (iv) it has not employed any broker or
finder in connection with the transactions contemplated by this Amendment. To
the best of its knowledge, Furman Selz acknowledges receipt of, and the
opportunity to review, the information that it believes necessary to make an
investment in the Shares."

          Except as amended by this Amendment, the Initial Letter shall remain
in full force and effect in accordance with its terms. This Amendment shall be
deemed to be part of the Initial Letter.

          This agreement may not be amended or modified except in writing and
shall be governed by and construed in accordance with the internal laws of the
State of New York.

          For the convenience of the parties, any number of counterparts of this
agreement may be executed by the parties hereto. Each such counterpart shall be,
and shall be deemed to be, an original instrument, but all such counterparts
taken together shall constitute one and the same Amendment.

          If the foregoing correctly sets forth our agreement and understanding,
we would appreciate your signing the enclosed copy of this Amendment and
returning the same to us.

                                         Very truly yours,

                                         FS PRIVATE INVESTMENTS LLC


                                         By: /S/ JAMES L. LUIKART
                                             Name:  James L. Luikart
                                             Title: Managing Member



AGREED AND ACCEPTED:

ASCENT PEDIATRICS, INC.


By: /s/ ALAN R. FOX
    Name:   Alan R. Fox
    Title:  President


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