DEPUY INC
SC 13D/A, 1998-07-28
ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES
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================================================================================
                               UNITED STATES
                     SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C.  20549
                                   ----------

                                SCHEDULE 13D
                 Under the Securities Exchange Act of 1934

                              Amendment No. 2

                                DEPUY, INC.
                              (Name of Issuer)

                                COMMON STOCK
                       (Title of Class of Securities)

                                   ----------

                                249726 10 0
                               (Cusip Number)

                               CORANGE LIMITED
                        CORANGE INTERNATIONAL LIMITED
                     CORANGE INTERNATIONAL HOLDING B.V.
                              PHARMINVEST S.A.
                      (Name of Persons Filing Statement)

                               Peter R. Douglas
                            Davis Polk & Wardwell
                             450 Lexington Avenue
                              New York, NY 10017
                            Tel No.: 212-450-4000
                   (Name, Address and Telephone Number of
                    Person Authorized to Receive Notices
                            and Communications)

                               July 21, 1998
          (Date of Event which Requires Filing of this Statement)

                                   ----------

               If the filing person has previously filed a statement on
Schedule 13G to report the acquisition which is the subject of this Schedule
13D, and is filing this statement because of Rule 13d-1(b)(3) or (4), check
the following:  [ ]

               Check the following box if a fee is being paid with this
statement:  [ ]

================================================================================




                                  SCHEDULE 13D

CUSIP No. 249726 10 0                                    Page ____ of ____ Pages

     1         NAME OF REPORTING PERSON
               S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               CORANGE LIMITED
     2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  [x]
                                                                        (b)  [ ]

     3         SEC USE ONLY

     4         SOURCE OF FUNDS*

               NOT APPLICABLE
     5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
               TO ITEMS 2(d) or 2(e)                 [ ]

     6         CITIZENSHIP OR PLACE OF ORGANIZATION

               BERMUDA
             NUMBER OF SHARES                   7     SOLE VOTING POWER
        BENEFICIALLY OWNED BY EACH
          REPORTING PERSON WITH

                                                      0
                                                8     SHARED VOTING POWER

                                                      83,000,000*
                                                9     SOLE DISPOSITIVE POWER

                                                      0
                                                10    SHARED DISPOSITIVE POWER

                                                      83,000,000*

    11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               3,168,745*
    12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
               SHARES*                                                       [ ]

    13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               3%
    14         TYPE OF REPORTING PERSON*

               CO
                                          *SEE INSTRUCTIONS BEFORE FILLING OUT!
SEC 1746 (9-88) 2 of 7


                                  SCHEDULE 13D

CUSIP No. 249726 10 0                                  Page ____ of ____ Pages

     1         NAME OF REPORTING PERSON
               S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               CORANGE INTERNATIONAL LIMITED
     2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  [x]
                                                                        (b)  [ ]

     3         SEC USE ONLY

     4         SOURCE OF FUNDS*

               NOT APPLICABLE
     5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
               TO ITEMS 2(d) or 2(e)                                         [ ]

     6         CITIZENSHIP OR PLACE OF ORGANIZATION

               BERMUDA
             NUMBER OF SHARES              7          SOLE VOTING POWER
        BENEFICIALLY OWNED BY EACH
          REPORTING PERSON WITH

                                                      0
                                           8          SHARED VOTING POWER

                                                      83,000,000*
                                           9          SOLE DISPOSITIVE POWER

                                                      0
                                           10         SHARED DISPOSITIVE POWER

                                                      83,000,000*

    11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               528,247*
    12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
               SHARES*                                                       [ ]

    13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               1%
    14         TYPE OF REPORTING PERSON*

               CO
                                          *SEE INSTRUCTIONS BEFORE FILLING OUT!
SEC 1746 (9-88) 2 of 7

                                  SCHEDULE 13D

CUSIP No. 249726 10 0                                  Page ____ of ____ Pages

     1         NAME OF REPORTING PERSON
               S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               CORANGE INTERNATIONAL HOLDING B.V.
     2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  [x]
                                                                        (b)  [ ]

     3         SEC USE ONLY

     4         SOURCE OF FUNDS*

               NOT APPLICABLE
     5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
               TO ITEMS 2(d) or 2(e)                                         [ ]

     6         CITIZENSHIP OR PLACE OF ORGANIZATION

               THE NETHERLANDS
             NUMBER OF SHARES             7          SOLE VOTING POWER
        BENEFICIALLY OWNED BY EACH
          REPORTING PERSON WITH

                                                     0
                                          8          SHARED VOTING POWER

                                                     83,000,000*
                                          9          SOLE DISPOSITIVE POWER

                                                     0
                                          10         SHARED DISPOSITIVE POWER

                                                     83,000,000*

    11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               13,272,193*
    12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
               SHARES*                                                       [ ]

    13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               13%
    14         TYPE OF REPORTING PERSON*

               CO
                                          *SEE INSTRUCTIONS BEFORE FILLING OUT!
SEC 1746 (9-88) 2 of 7

                                  SCHEDULE 13D

CUSIP No. 249726 10 0                                   Page ____ of ____ Pages

     1         NAME OF REPORTING PERSON
               S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               PHARMINVEST S.A.
     2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  [x]
                                                                        (b)  [ ]

     3         SEC USE ONLY

     4         SOURCE OF FUNDS*

               NOT APPLICABLE
     5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
               TO ITEMS 2(d) or 2(e)                                         [ ]

     6         CITIZENSHIP OR PLACE OF ORGANIZATION

               LUXEMBOURG
             NUMBER OF SHARES              7          SOLE VOTING POWER
        BENEFICIALLY OWNED BY EACH
          REPORTING PERSON WITH
                                                      0
                                           8          SHARED VOTING POWER

                                                      83,000,000*
                                           9          SOLE DISPOSITIVE POWER

                                                      0
                                           10         SHARED DISPOSITIVE POWER

                                                      83,000,000*

    11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               66,030,815*
    12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
               SHARES*                                                       [ ]

    13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

               67%
    14         TYPE OF REPORTING PERSON*

               CO
                                          *SEE INSTRUCTIONS BEFORE FILLING OUT!
SEC 1746 (9-88) 2 of 7


               *Introduction

               Corange Limited ("Corange") hereby amends and supplements its
Report on Schedule 13D, originally filed on June 3, 1997 and amended by
Amendment No. 1 on March 31, 1998 (as amended, the "Schedule 13D") with
respect to shares of common stock, $.01 par value (the "Shares") of DePuy,
Inc. (the "Company").  On July 21, 1998, Corange and Corange International
Limited ("CIL"), Corange International Holding B.V. ("CIHBV") and Pharminvest
S.A. ("Pharminvest", and together with Corange, CIL and CIHBV, the "Sellers"),
all indirect wholly owned subsidiaries of Roche Holding Ltd, entered into a
Stockholder Agreement (the "Stockholder Agreement") with Johnson & Johnson
("Parent") and LIB Acquisition Corp., a wholly owned subsidiary of Parent (the
"Purchaser"), pursuant to which Sellers  have agreed with Parent and the
Purchaser to tender to the Purchaser, pursuant to a tender offer by Purchaser
(the "Offer"), or sell to the Purchaser immediately following the Offer, in
each case at a price of $35 per Share, all the Shares owned by Sellers
representing an aggregate of 83,000,000 Shares or approximately 84% of the
Shares outstanding as of July 21, 1998.  In addition, any Shares that Sellers
may subsequently acquire (by exercise of stock options or otherwise)
automatically become subject to the provisions of the Stockholder Agreement.
If the Purchaser accepts for payment and pays for any Shares tendered under
the Offer, the Purchaser must purchase all the Shares subject to the
Stockholder Agreement not accepted for payment by the Purchaser under the
Offer.  Pursuant to the Stockholder Agreement, Sellers have also delivered a
proxy to the Purchaser to vote, or grant a consent or approval in respect of,
the Shares subject to the Stockholder Agreement against any transaction with a
third party other than the transactions contemplated by the Offer and the
merger ("Merger") pursuant to the Agreement and Plan of Merger (the "Merger
Agreement") dated July 21, 1998 among Parent, Purchaser and the Company.

               Unless otherwise indicated, each capitalized terms used but not
defined herein shall have the meaning assigned to such term in the Schedule
13D.

               Item 1.  Security and Issuer.

               This Schedule 13D relates to Common Stock, $.01 par value per
share of DePuy, Inc.  The issuer is DePuy, Inc., a Delaware corporation.  The
address of the issuer's principal executive office is 700 Orthopaedic Drive,
Warsaw, Indiana 46580.

               Item 2.  Identity and Background

               On March 5, 1998, Roche Healthcare Limited, a Bermuda
corporation ("RHL"), consummated its acquisition of all of the outstanding
capital stock of Corange (the "Acquisition").  At the time of the Acquisition,
Corange owned, directly and through its direct and indirect wholly-owned
subsidiaries, 83,000,000 Shares.

               Each of RHL, Corange, CIL, CIHBV and Pharminvest is an indirect
wholly owned subsidiary of Roche Holding Ltd, a Swiss corporation ("Holding").
Dr. h.c. Paul Sacher, an individual and citizen of Switzerland ("Dr. Sacher")
has, pursuant to an agreement, the power to vote a majority of the voting
securities of Holding.  RHL, Corange, CIL, CIHBV, Pharminvest, Holding and Dr.
Sacher are herein referred to collectively as the "Reporting Persons".

               The address of the principal offices of RHL is Church &
Parliament Its., Hamilton, HM 12, Bermuda.  The address of the principal
offices of Holding is Grenzacherstrasse 124, Basel 4070, Switzerland.  The
business address of Dr. Sacher is Haus auf Burg, Muensterplatz 4, Basel 4051,
Switzerland.

               The name, citizenship, present principal occupation and
material position held during the last five years of each of the officers and
directors of each Reporting Person are set forth on Schedules A, B, C, D, E
and F hereto.  During the last five years, none of the Reporting Persons, nor
to the knowledge of the Reporting Persons, any of the persons listed in
Schedules A-F (i) has been convicted in a criminal proceeding (excluding
traffic violations and similar misdemeanors) or (ii) was a party to a civil
proceeding of a judicial or administrative body of competent jurisdiction and
as a result of such proceeding was or is subject to a judgment, decree or
final order enjoining future violations of, or prohibiting or mandating
activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

               Item 3.  Source and Amount of Funds or Other Consideration.

               Not applicable.

               Item 4.  Purpose of the Transaction.

               The information set forth in "Introduction" is incorporated
herein by reference.  Other than as contemplated by the Stockholder Agreement,
the Offer and the Merger Agreement, Sellers have no plans which relate to or
would result in any transaction described in Schedule 13D, item 4(a) - (j).

               Item 5.  Interest in Securities of Issuer.

               (a)-(b) The information set forth on the inside
cover pages is incorporated herein by reference.

               (c) None.

               (d) None.

               (e) Not applicable.

               Item 6.  Contracts, Arrangements, Understandings or
Relationships with Respect to Securities of the Issuer.

               The information set forth in "Introduction" is incorporated
herein by reference.  The sale is to take place pursuant to the Offer.  The
Offer is being made pursuant to the Merger Agreement.  The Offer is
conditioned upon, among other things, (i) the Shares owned by Sellers having
been validly tendered to the Purchaser as required by the Stockholder
Agreement, (ii) any waiting period under the Hart-Scott-Rodino Antitrust
Improvements Act of 1976, as amended, having expired or been terminated and
(iii) any approval under Council Regulation (EEC) No. 4064/89 of 21 December
1989, as amended, having been obtained.  There can be no assurance that all
conditions precedent of the Offer will be satisfied or waived and that the
sale of Shares to Purchaser by Sellers will be consummated.

               Item 7.  Material to be Filed as Exhibits.

               99.1 Text of Press Release dated July 21, 1998, issued by
Holding.

               99.2 Agreement and Plan of Merger dated as of July 21, 1998,
among  Parent, the Purchaser and Company.

               99.3 Stockholder Agreement dated as of July 21, 1998, among
Parent, the Purchaser and Sellers.

                                  SIGNATURES

               After reasonable inquiry and to the best knowledge and belief
of the undersigned, the undersigned certifies that the information set forth
in this statement is true, complete and correct.

Date: July 28, 1998
                                   CORANGE LIMITED


                                    By:  /s/ John R. Talbot
                                       -----------------------------
                                       Name: John R. Talbot
                                       Title: Director


                                    CORANGE INTERNATIONAL LIMITED


                                    By:  /s/ John R. Talbot
                                       -----------------------------
                                       Name: John R. Talbot
                                       Title: Director


                                    CORANGE INTERNATIONAL HOLDING B.V.


                                    By:  /s/ W. J. van der Hoek
                                       -----------------------------
                                       Name: W.J. van der Hoek
                                       Title: Director


                                    PHARMINVEST S.A.


                                    By:  /s/ W. J. van der Hoek
                                       -----------------------------
                                       Name: W.J. van der Hoek
                                       Title: Director


                                                                    SCHEDULE A


                      Executive Officers and Directors(*)
                                      of
                                Corange Limited


               The names of the Directors and the names and titles of the
Executive Officers of Corange and their business addresses and principal
occupations are set forth below.  If no address is given, the Director's or
Executive Officer's business address is that of RHL.  Each individual is a
citizen of Bermuda.


Name, Business Address                Present Principal Occupation
- ----------------------                ----------------------------

John R. Talbot....................    Member of the Board

Graham Collis.....................    Member of the Board

George Burch......................    Member of the Board

C.F. Alexander Cooper.............    Member of the Board

Nicolas Trollope..................    Alternate Director


                                                                    SCHEDULE B


                      Executive Officers and Directors(*)
                                      of
                         Corange International Limited


               The names of the Directors and the names and titles of the
Executive Officers of CIL and their business addresses and principal
occupations are set forth below.  If no address is given, the Director's or
Executive Officer's business address is that of RHL.  Each individual is a
citizen of Bermuda.

Name, Business Address                Present Principal Occupation
- ----------------------                ----------------------------

John R. Talbot....................    Member of the Board

Graham Collis.....................    Member of the Board

George Burch......................    Member of the Board

C.F. Alexander Cooper.............    Member of the Board

Nicolas Trollope..................    Alternate Director


                                                                    SCHEDULE C


                      Executive Officers and Directors(*)
                                      of
                      Corange International Holding B.V.


               The names of the Directors and the names and titles of the
Executive Officers of CIHBV and their business addresses and principal
occupations are set forth below.

Name, Business Address                 Present Principal Occupation
- ----------------------                 ----------------------------

Peter Bieri........................    Member of the Board

Willem J. van der Hoek.............    Member of the Board

Aart Cooiman.......................    Member of the Board




                                                                    SCHEDULE D


                      Executive Officers and Directors(*)
                                      of
                               Pharminvest S.A.


               The names of the Directors and the names and titles of the
Executive Officers of Pharminvest and their business addresses and principal
occupations are set forth below.

Name, Business Address                 Present Principal Occupation
- ----------------------                 ----------------------------

Dr. Jurgen Friedrich...............    Chairman of the Board

Peter Bieri........................    Member of the Board

Willem J. van der Hoek.............    Member of the Board




                                                                    SCHEDULE E


                      Executive Officers and Directors(*)
                                      of
                           Roche Healthcare Limited


               The names of the Directors and the names and titles of the
Executive Officers of Roche Healthcare Limited and their business addresses
and principal occupations are set forth below.  If no address is given, the
Director's or Executive Officer's business address is that of RHL.  Each
individual is a citizen of Bermuda.

Name, Business Address                Present Principal Occupation
- ----------------------                ----------------------------

John R. Talbot....................    Member of the Board

Graham Collis.....................    Member of the Board

George Burch......................    Member of the Board

C.F. Alexander Cooper.............    Member of the Board

Nicolas Trollope..................    Alternate Director



                                                                    SCHEDULE F


                      Executive Officers and Directors(*)
                                      of
                               Roche Holding Ltd


               The names of the Directors and the names and titles of the
Executive Officers of Roche Holding Ltd and their business addresses and
principal occupations are set forth below.  If no address is given, the
Director's or Executive Officer's business address is that of Roche Holding
Ltd.  Unless otherwise indicated, each occupation set forth opposite an
individual's name refers to Roche Holding Ltd and each individual is a Swiss
citizen, except that Prof. Knowles is a British citizen and Mr. Belingard is a
French citizen.

Business Address
Roche Holding Ltd
Grenzacherstrasse 124
CH-4070 Basel

<TABLE>
<CAPTION>

Name                                                     Present Principal Occupation
- ----                                                     ----------------------------

<S>                                                      <C>
Dr. h.c. Fritz Gerber................................    Executive Chairman of the Board of Directors

Dr. Andres F. Leuenberger............................    Vice Chairman of the Board of Directors

Rolf Hanggi..........................................    Vice Chairman of the Board of Directors

Andre Hoffmann.......................................    Member of the Board of Directors, Venture Capitalist
Ashwood Associates
17 Cromwell Place
London SW7 2LA, England

Dr. Franz B. Humer...................................    Member of the Board of Directors, Chairman of the
                                                         Corporate Executive Committee, Head of
                                                         Pharmaceuticals Division

Dr. Henri B. Meier...................................    Member of the Board of Directors and Executive
                                                         Committee, Group Chief Financial Officer

Dr. Andreas Oeri.....................................    Member of the Board of Directors, Surgeon
Clarahofweg 19a
4005 Basel, Switzerland

Prof. Dr. jur. Kurt Jenny............................    Member of the Board of Directors, Lawyer
Aeschengraben 18
4051 Basel, Switzerland

Prof. Dr. Werner Stauffacher.........................    Member of the Board of Directors, Head of
Head of Department of Research                            Department of Research, University of Basel
University of Basel
Hebelstrasse 32
4056 Basel, Switzerland

Prof. Charles Weissmann..............................    Member of the Board of Directors, Professor,
Institut fur Molekularbiologie I                          University of Zurich
der Universitat Zurich
Hoenggerberg
8093 Zurich, Switzerland

Dr. Markus Altwegg...................................    Member of the Executive Committee, Head of Roche
                                                         Pharma Switzerland

Mr. Jean-Luc Belingard...............................    Member of the Executive Committee, Head of
                                                         Diagnostics Division

Dr. Roland Bronnimann................................    Member of the Executive Committee, Head of
                                                         Vitamins and Fine Chemicals Division

Prof. Dr. Jonathan Knowles...........................    Member of the Executive Committee, Head of Global
                                                         Pharmaceutical Research

Dr. Kuno Sommer......................................    Member of the Executive Committee, Head of
                                                         Fragrances and Flavours Division

Dr. Gerald Moller....................................    Member of the Executive Committee, Head of
                                                         Pharmaceutical Development
</TABLE>



                                 EXHIBIT INDEX

Exhibit No.              Description                                       Page
- -----------              -----------                                       ----

99.1           Text of Press Release dated July 21, 1998, issued by
               Holding.

99.2           Agreement and Plan of Merger dated as of July 21, 1998,
               among  Parent, the Purchaser and Company.

99.3           Stockholder Agreement dated as of July 21, 1998, among
               Parent, the Purchaser and Sellers.

                                                                    Exhibit 99.1

Basel, July 21, 1998

Roche sells its majority stake in DePuy

Roche and Johnson & Johnson have announced today, that they have entered into an
agreement under which Roche will sell its 84% participation in DePuy at $35 per
share, which equals a purchase price of 2.9 billion $. Johnson and Johnson will
seek to acquire through a cash tender offer all for the outstanding common stock
of DePuy for 35 $ per share. This transaction, which is supported by the board
and the management of DePuy, will create one of the world leading orthopedics
groups will pro forma annual sales of over 1.4 billion $.

Roche acquired DePuy as part of the acquisition of the Corange group, which was
completed on 5 March 1998. Through the acquisition of Corange, Roche achieved
its primary objectives to become the market leader in the global diagnostics
business and to strengthen its position in the world pharmaceutical market.
After a thorough review of the orthopedics market and its ongoing consolidation
process Roche came to the conclusion that it was in its best interest to
continue to focus on the established core businesses.

The transaction is subject to customary conditions including clearance under US
and European merger control laws. The offer will begin by 27 July and will
remain open for a minimum of 20 business days.

Johnson & Johnson with 1997 sales of nearly 23 billion $, is one of the world's
leading manufacturers of health care products for the consumer, pharmaceutical
and professional markets. Johnson & Johnson has 91 000 employees and 180
operating companies in 51 countries around the world, selling products in more
than 175 countries.

The DePuy Group is one of the world's leading manufacturers of artificial joints
and other orthopedic products. It employs more than 3 000 people and recorded
sales of around 770 million $ in 1997. Its products range from artificial joints
and implants to orthopedic instruments and arthroscopic equipment.

                                                                EXHIBIT 99.2

                                                                CONFORMED COPY



================================================================================





                         AGREEMENT AND PLAN OF MERGER


                                     among


                              JOHNSON & JOHNSON,


                             LIB ACQUISITION CORP.


                                      and


                                  DEPUY, INC.






                           Dated as of July 21, 1998





================================================================================







                               TABLE OF CONTENTS


                         AGREEMENT AND PLAN OF MERGER



                                   ARTICLE I

                                   THE OFFER
                                                                           Page
                                                                           ----

Section 1.01   The Offer.......................................................2
Section 1.02   Company Actions.................................................4


                                  ARTICLE II

                                  THE MERGER

Section 2.01   The Merger......................................................6
Section 2.02   Closing.........................................................6
Section 2.03   Effective Time..................................................6
Section 2.04   Effects of the Merger...........................................7
Section 2.05   Certificate of Incorporation and Bylaws.........................7
Section 2.06   Directors.......................................................7
Section 2.07   Officers........................................................7


                                  ARTICLE III

               EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE
              CONSTITUENT CORPORATIONS; EXCHANGE OF CERTIFICATES

Section 3.01   Effect on Capital Stock.........................................7
Section 3.02   Exchange of Certificates........................................9


                                  ARTICLE IV

                  REPRESENTATIONS & WARRANTIES OF THE COMPANY

Section 4.01   Organization...................................................12
Section 4.02   Company Subsidiaries; Equity Interests.........................12
Section 4.03   Capitalization.................................................13
Section 4.04   Authority......................................................14
Section 4.05   Consent and Approvals; No Violations...........................14
Section 4.06   SEC Documents; Financial Statements............................15
Section 4.07   Information Supplied...........................................16
Section 4.08   Absence of Certain Changes or Events...........................16
Section 4.09   Litigation.....................................................17
Section 4.10   Contracts......................................................17
Section 4.11   Compliance with Laws...........................................18
Section 4.12   Environmental Matters..........................................19
Section 4.13   Absence of Changes in Benefit Plans; Labor Relations...........20
Section 4.14   ERISA Compliance...............................................20
Section 4.15   Taxes..........................................................23
Section 4.16   No Excess Parachute Payments...................................23
Section 4.17   Title to Properties............................................24
Section 4.18   Intellectual Property..........................................24
Section 4.19   Agreements for Distribution Outside the United States..........25
Section 4.20   Voting Requirements............................................25
Section 4.21   State Takeover Statutes........................................26
Section 4.22   Brokers; Schedule of Fees and Expenses.........................26
Section 4.23   Opinion of Financial Advisor...................................26


                                   ARTICLE V

                        REPRESENTATIONS AND WARRANTIES
                               OF PARENT AND SUB

Section 5.01   Organization...................................................26
Section 5.02   Authority......................................................27
Section 5.03   Consents and Approvals; No Violations..........................27
Section 5.04   Information Supplied...........................................28
Section 5.05   Interim Operations of Sub......................................28
Section 5.06   Brokers........................................................29
Section 5.07   Financing......................................................29


                                  ARTICLE VI

                                   COVENANTS

Section 6.01   Conduct of Business............................................29
Section 6.02   No Solicitation................................................32
Section 6.03   Certain Tax Matters............................................33
Section 6.04   Other Actions..................................................34
Section 6.05   Advice of Changes; Filings.....................................34


                                  ARTICLE VII

                             ADDITIONAL AGREEMENTS

Section 7.01   Company Stockholder Approval; Preparation of Proxy Statement...35
Section 7.02   Access to Information; Confidentiality.........................36
Section 7.03   Reasonable Efforts; Notification...............................36
Section 7.04   Cooperation....................................................37
Section 7.05   Stock Option Plans.............................................38
Section 7.06   Indemnification, Exculpation and Insurance.....................39
Section 7.07   Directors......................................................40
Section 7.08   Fees and Expenses..............................................41
Section 7.09   Transfer Taxes.................................................41
Section 7.10   Public Announcements...........................................41
Section 7.11   Severance Agreements...........................................42
Section 7.12   Continuation of Benefits.......................................42
Section 7.13   Stop Transfer..................................................42
Section 7.14   Purchase of Foreign Subsidiaries...............................43


                                 ARTICLE VIII

                                  CONDITIONS

Section 8.01   Conditions to Each Party's Obligation to Effect the Merger.....43


                                  ARTICLE IX

                           TERMINATION AND AMENDMENT

Section 9.01   Termination....................................................44
Section 9.02   Effect of Termination..........................................45
Section 9.03   Amendment......................................................45
Section 9.04   Extension; Waiver..............................................46
Section 9.05   Procedure for Termination, Amendment, Extension or Waiver......46


                                   ARTICLE X

                                 MISCELLANEOUS

Section 10.01  Nonsurvival of Representations, Warranties and Agreements......46
Section 10.02  Notices........................................................47
Section 10.03  Interpretation.................................................48
Section 10.04  Counterparts...................................................48
Section 10.05  Entire Agreement; Third Party Beneficiaries....................49
Section 10.06  Governing Law..................................................49
Section 10.07  Assignment.....................................................49
Section 10.08  Enforcement....................................................49
Section 10.09  Severability...................................................50
Section 10.10  Compliance with Law............................................50



EXHIBIT A Conditions of the Offer............................................A-1





                        AGREEMENT AND PLAN OF MERGER dated as of July 21,
                        1998, among JOHNSON & JOHNSON, a New Jersey
                        corporation ("Parent"), LIB ACQUISITION CORP., a
                        Delaware corporation and a wholly-owned subsidiary
                        of Parent ("Sub"), and DEPUY, INC., a Delaware
                        corporation (the "Company").


       WHEREAS, the respective Boards of Directors of Parent, Sub and the
Company have approved and found advisable this Agreement and the acquisition
of the Company by Parent on the terms and subject to the conditions set forth
in this Agreement;

       WHEREAS, in furtherance of such acquisition, Parent proposes to cause
Sub to make a tender offer to purchase all the outstanding shares of Common
Stock, par value $0.01 per share, of the Company (the "Company Common Stock";
all the outstanding shares of Company Common Stock being hereinafter
collectively referred to as the "Shares") at a purchase price of $35 per Share
(the "Offer Price"), net to the seller in cash, without interest thereon, upon
the terms and subject to the conditions set forth in this Agreement (as it may
be amended from time to time as permitted under this Agreement, the "Offer");
and the Board of Directors of the Company has adopted resolutions approving
the Offer and the Merger (as defined below), recommending that the Company's
stockholders accept the Offer and approving the acquisition of Shares by Sub
pursuant to the Offer and the Stockholder Agreement (as defined below);

       WHEREAS, the respective Boards of Directors of Parent, Sub and the
Company have each approved the merger of Sub into the Company (the "Merger"),
upon the terms and subject to the conditions set forth in this Agreement,
whereby each Share, other than Shares owned directly or indirectly by Parent
or the Company and Dissenting Shares (as defined in Section 3.01(d)), will be
converted into the right to receive the price per Share paid in the Offer;

       WHEREAS, as an inducement to Parent to enter into this Agreement,
Parent, Sub and certain stockholders of the Company have entered into a
Stockholder Agreement dated as of the date hereof pursuant to which such
stockholders have, among other things, agreed to sell all such stockholders'
Shares to Sub at a cash price per Share equal to the Offer Price, upon the
terms and subject to the conditions set forth in such Stockholder Agreement
(the "Stockholder Agreement"); and

       WHEREAS, Parent, Sub and the Company desire to make certain
representations, warranties, covenants and agreements in connection with the
Offer and the Merger and also to prescribe various conditions to the Offer and
the Merger.


       NOW, THEREFORE, in consideration of the foregoing and the mutual
covenants and agreements herein contained, and intending to be legally bound
hereby, Parent, Sub and the Company hereby agree as follows:


                                   ARTICLE I

                                   The Offer

       SECTION 1.01.  The Offer.  (a)  Provided that none of the conditions
set forth on Exhibit A hereto shall have occurred and be continuing, as
promptly as practicable but in no event later than five business days after
the date of the public announcement (on the date hereof or the following day)
by Parent and the Company of this Agreement, Sub shall, and Parent shall cause
Sub to, commence (within the meaning of Rule 14d-2 under the Securities
Exchange Act of 1934, as amended (the "Exchange Act")), the Offer.  The
obligation of Sub to, and of Parent to cause Sub to, commence the Offer,
conduct and consummate the Offer and accept for payment, and pay for, any
Shares tendered and not withdrawn pursuant to the Offer shall be subject only
to the conditions set forth in Exhibit A (the "Offer Conditions") (any of
which may be waived in whole or in part by Sub in its sole discretion;
provided that, without the express written consent of the Company, Sub may not
waive the Stockholder Agreement Condition (as defined in Exhibit A)).  Sub
expressly reserves the right, subject to compliance with the Exchange Act, to
modify the terms of the Offer, except that, without the express written
consent of the Company, Sub shall not (i) reduce the number of Shares subject
to the Offer, (ii) reduce the Offer Price, (iii) add to or modify the Offer
Conditions, (iv) except as provided in the next sentence, extend the Offer,
(v) change the form of consideration payable in the Offer or (vi) amend or
alter any other term of the Offer in any manner adverse to the holders of the
Shares.  Notwithstanding the foregoing, Sub may, without the consent of the
Company, (A) extend the Offer for a specified period, if at the scheduled or
any extended expiration date of the Offer any of the Offer Conditions shall
not be satisfied or waived, until such time as such conditions are satisfied
or waived, (B) extend the Offer for any period required by any rule,
regulation, interpretation or position of the Securities and Exchange
Commission (the "SEC") or the staff thereof applicable to the Offer, (C)
extend the Offer for up to ten business days if there have not been validly
tendered and not withdrawn prior to the expiration of the Offer such number of
Shares that, together with Shares subject to the Stockholder Agreement which
have not been validly tendered, would constitute at least 90% of the fully
diluted Shares as of the date of determination and (D) extend the Offer for any
reason for up to two business days; provided that no more than three
extensions shall be permitted under clauses (C) and (D) of this sentence.
Subject only to the conditions set forth in Exhibit A, Sub shall, and Parent
shall cause Sub to, accept for payment, and pay for, all Shares validly
tendered and not withdrawn pursuant to the Offer that Sub becomes obligated to
accept for payment, and pay for, pursuant to the Offer as soon as practicable
after the expiration of the Offer.

       (b)  On the date of commencement of the Offer, Parent and Sub shall
file with the SEC a Tender Offer Statement on Schedule 14D-1 (such Schedule
14D-1, as supplemented or amended from time to time, the "Schedule 14D-1")
with respect to the Offer, which shall contain an offer to purchase and a
related letter of transmittal and summary advertisement (such Schedule 14D-1
and the documents included therein pursuant to which the Offer will be made,
together with any supplements or amendments thereto, the "Offer Documents").
Parent and Sub agree that the Offer Documents shall comply as to form in all
material respects with the Exchange Act and the rules and regulations
promulgated thereunder, and the Offer Documents, on the date first published,
sent or given to the Company's stockholders, shall not contain any untrue
statement of a material fact or omit to state any material fact required to
be stated therein or necessary in order to make the statements therein, in
light of the circumstances under which they were made, not misleading, except
that no representation or warranty is made by Parent or Sub with respect to
written information supplied by the Company or any of its stockholders
specifically for inclusion or incorporation by reference in the Offer
Documents.  Parent, Sub and the Company each agrees promptly to correct any
written information provided by it for use in the Offer Documents if and to
the extent that such information shall have become false or misleading in any
material respect, and Parent and Sub further agree to take all steps necessary
to cause the Schedule 14D-1 as so corrected to be filed with the SEC and the
other Offer Documents as so corrected to be disseminated to holders of Shares,
in each case as and to the extent required by applicable Federal securities
laws.  The Company and its counsel shall be given reasonable opportunity to
review and comment upon the Offer Documents prior to their filing with the SEC
or dissemination to the stockholders of the Company.  Parent and Sub agree to
provide the Company and its counsel any comments Parent, Sub or their counsel
may receive from the SEC or its staff with respect to the Offer Documents
promptly after the receipt of such comments.

       (c)  Parent shall provide or cause to be provided to Sub on a timely
basis the funds sufficient to accept for payment, and pay for, any and all
Shares that Sub becomes obligated to accept for payment, and pay for, pursuant
to the Offer.

       (d)  Sub shall be entitled to deduct and withhold from the
consideration otherwise payable pursuant to the Offer such amounts as may
be required to be deducted and withheld with respect to the making of such
payment under the Internal Revenue Code of 1986, as amended (the "Code"),
or under any provision of state, local or foreign tax law; provided,
however, that Sub shall promptly pay any amounts deducted and withheld
hereunder to the applicable governmental authority, shall promptly file all
tax returns and reports required to be filed in respect of such deductions
and withholding, and shall promptly provide to the Company proof of such
payment and a copy of all such tax returns and reports.

       SECTION 1.02.  Company Actions.  (a)  The Company hereby approves of
and consents to the Offer and represents that the Board of Directors of the
Company, at a meeting duly called and held, duly adopted resolutions approving
this Agreement and the Stockholder Agreement, the Offer and the Merger,
determining that the terms of the Offer and the Merger are fair to, and in the
best interests of, the Company's stockholders and recommending that the
Company's stockholders accept the Offer, tender their Shares pursuant to the
Offer and approve and adopt this Agreement (if required).  The Company
represents that its Board of Directors has received the opinion of Bear,
Stearns & Co. Inc. ("Bear, Stearns") that, as of such date and based upon and
subject to the matters set forth therein, the cash consideration to be
received by the holders of Shares pursuant to the Offer and the Merger was
fair from a financial point of view to such holders, and a complete and
correct signed copy of such opinion has been delivered by the Company to
Parent.

       (b)  On the date the Offer Documents are filed with the SEC, the
Company shall file with the SEC a Solicitation/   Recommendation Statement on
Schedule 14D-9 with respect to the Offer (such Schedule 14D-9, as supplemented
or amended from time to time, the "Schedule 14D-9") containing the
recommendation described in Section 1.02(a) and shall mail the Schedule 14D-9
to the stockholders of the Company.  The Schedule 14D-9 shall comply as to
form in all material respects with the requirements of the Exchange Act and
the rules and regulations promulgated thereunder and, on the date filed with
the SEC and on the date first published, sent or given to the Company's
stockholders, shall not contain any untrue statement of a material fact or
omit to state any material fact required to be stated therein or necessary in
order to make the statements therein, in light of the circumstances under
which they were made, not misleading, except that no representation or
warranty is made by the Company with respect to written information supplied
by Parent or Sub specifically for inclusion in the Schedule 14D-9.  The
Company, Parent and Sub each agree promptly to correct any written information
provided by it for use in the Schedule 14D-9 if and to the extent that such
information shall have become false or misleading in any material respect, and
the Company further agrees to take all steps necessary to amend or supplement
the Schedule 14D-9 and to cause the Schedule 14D-9 as so amended or
supplemented to be filed with the SEC and disseminated to the Company's
stockholders, in each case as and to the extent required by applicable Federal
securities laws.  Parent and its counsel shall be given reasonable opportunity
to review and comment upon the Schedule 14D-9 prior to its filing with the SEC
or dissemination to stockholders of the Company.  The Company agrees to
provide Parent and its counsel any comments the Company or its counsel may
receive from the SEC or its staff with respect to the Schedule 14D-9 promptly
after the receipt of such comments.

       (c)  In connection with the Offer and the Merger, the Company shall
cause its transfer agent to furnish Sub promptly with mailing labels
containing the names and addresses of the record holders of Shares as of a
recent date and of those persons becoming record holders subsequent to such
date, together with copies of all lists of stockholders, security position
listings and computer files and all other information in the Company's
possession or control regarding the beneficial owners of Shares, and shall
furnish to Sub such information and assistance (including updated lists of
stockholders, security position listings and computer files) as Parent may
reasonably request in communicating the Offer to the Company's stockholders.
Subject to the requirements of applicable law, and except for such steps as
are necessary to disseminate the Offer Documents and any other documents
necessary to consummate the Merger, Parent and Sub and their agents shall hold
in confidence the information contained in any such labels, listings and
files, will use such information only in connection with the Offer and the
Merger and, if this Agreement shall be terminated, will, upon request, promptly
deliver, and will use their best efforts to cause their agents promptly to
deliver, to the Company all copies of such information (and all copies of
information derived therefrom) then in their possession or control.


                                  ARTICLE II

                                  The Merger

       SECTION 2.01.  The Merger.  Upon the terms and subject to the
conditions set forth in this Agreement, and in accordance with the Delaware
General Corporation Law (the "DGCL"), Sub shall be merged with and into the
Company at the Effective Time.  Following the Effective Time, the separate
corporate existence of Sub shall cease and the Company shall continue as the
surviving corporation (the "Surviving Corporation") and shall succeed to and
assume all the rights and obligations of Sub in accordance with the DGCL.  At
the election of Parent, any direct or indirect wholly-owned subsidiary (as
defined in Section 10.03) of Parent may be substituted for Sub as a constituent
corporation in the Merger.  In such event, the parties agree to execute an
appropriate amendment to this Agreement in order to reflect the foregoing.

       SECTION 2.02.  Closing.  The closing of the Merger will take place at
10:00 a.m. (New York City time) on a date to be specified by Parent or Sub,
which shall be no later than the second business day after satisfaction or
waiver of the conditions set forth in Article VIII (the "Closing Date"), at
the offices of Cravath, Swaine & Moore, Worldwide Plaza, 825 Eighth Avenue,
New York, New York 10019, unless another date, time or place is agreed to in
writing by the parties hereto.

       SECTION 2.03.  Effective Time.  Subject to the provisions of this
Agreement, as soon as practicable on or after the Closing Date, the parties
shall file a certificate of merger or other appropriate documents (in any such
case, the "Certificate of Merger") executed in accordance with the relevant
provisions of the DGCL and shall make all other filings or recordings required
under the DGCL and other applicable law.  The Merger shall become effective at
such time as the Certificate of Merger is duly filed with the Delaware
Secretary of State, or at such other time specified in the Certificate of
Merger as Sub and the Company shall agree (the time the Merger becomes
effective being hereinafter referred to as the "Effective Time").

       SECTION 2.04.  Effects of the Merger.  The Merger shall have the
effects set forth in Section 259 of the DGCL.

       SECTION 2.05.  Certificate of Incorporation and Bylaws.  (a)  The
Certificate of Incorporation of the Company (the "Certificate of
Incorporation"), as in effect immediately prior to the Effective Time, shall
be the certificate of incorporation of the Surviving Corporation until
thereafter changed or amended as provided therein or by applicable law.

       (b)  The bylaws of the Company (the "Bylaws") as in effect immediately
prior to the Effective Time shall be the bylaws of the Surviving Corporation,
until thereafter changed or amended as provided therein or by applicable law.

       SECTION 2.06.  Directors.  The directors of Sub immediately prior to
the Effective Time, and Michael J. Dormer and James A. Lent, shall be the
directors of the Surviving Corporation, until the earlier of their resignation
or removal or until their respective successors are duly elected and
qualified, as the case may be.

       SECTION 2.07.  Officers.  The officers of the Company immediately prior
to the Effective Time shall be the officers of the Surviving Corporation,
until the earlier of their resignation or removal or until their respective
successors are duly elected and qualified, as the case may be.


                                  ARTICLE III

               Effect of the Merger on the Capital Stock of the
              Constituent Corporations; Exchange of Certificates

       SECTION 3.01.  Effect on Capital Stock.  As of the Effective Time, by
virtue of the Merger and without any action on the part of the holder of any
Shares or any shares of capital stock of Sub:

      (a)  Capital Stock of Sub.  Each issued and outstanding share of capital
     stock of Sub shall be converted into and become one fully paid and
     nonassessable share of Common Stock, par value $.01 per share, of the
     Surviving Corporation.

      (b)  Cancelation of Treasury Stock and Parent Owned Stock.  Each Share
     that is owned by the Company and each Share that is owned by Parent or
     Sub shall automatically be canceled and retired and shall cease to
     exist, and no consideration shall be delivered in exchange therefor.
     Each Share that is owned by any direct or indirect wholly-owned
     subsidiary of Parent (other than Sub) or the Company shall remain
     outstanding without change.

      (c)  Conversion of Company Common Stock.  Subject to Section 3.01(d),
     each issued and outstanding Share (other than Shares to be canceled or
     to remain outstanding in accordance with Section 3.01(b) and other
     than Dissenting Shares) shall be converted into the right to receive
     from the Surviving Corporation in cash, without interest, the Offer
     Price (the "Merger Consideration").  As of the Effective Time, all
     such Shares shall no longer be outstanding and shall automatically be
     canceled and retired and shall cease to exist, and each holder of a
     certificate representing any such Shares shall cease to have any
     rights with respect thereto, except the right to receive the Merger
     Consideration, without interest.

      (d)  Shares of Dissenting Stockholders.  Notwithstanding anything in
     this Agreement to the contrary, any issued and outstanding Shares held
     by a person (a "Dissenting Stockholder") who has neither voted in
     favor of the Merger nor consented in writing thereto and otherwise
     complies with all the applicable provisions of the DGCL concerning the
     right of holders of Company Common Stock to dissent from the Merger
     and require appraisal of their Shares ("Dissenting Shares") shall not
     be converted as described in Section 3.01(c) but shall be converted
     into the right to receive such consideration as may be determined to
     be due to such Dissenting Stockholder pursuant to the laws of the
     State of Delaware.  If, after the Effective Time, such Dissenting
     Stockholder withdraws his demand for appraisal or fails to perfect or
     otherwise loses his right to appraisal, in any case pursuant to the
     DGCL, his Shares shall be deemed to be converted as of the Effective
     Time into the right to receive the Merger Consideration.  The Company
     shall give Parent (i) prompt notice of any demands for appraisal of
     Shares received by the Company and (ii) if and after Sub shall have
     accepted for payment Shares pursuant to and subject to the Offer
     Conditions, the opportunity to participate in and direct all
     negotiations and proceedings with respect to any such demands.  The
     Company shall not, without the prior written consent of Parent, make
     any payment with respect to, or settle, offer to settle or otherwise
     negotiate, any such demands.

       SECTION 3.02.  Exchange of Certificates.  (a)  Paying Agent.  Prior
to the Effective Time, Parent shall designate a substantial bank or trust
company to act as paying agent in the Merger (the "Paying Agent").  Parent
shall cause the Surviving Corporation to deposit with the Paying Agent in
separate trust for holders of the Certificates (as defined in Section
3.02(b)) immediately available funds in an amount sufficient for the
payment of the aggregate Merger Consideration for the Shares converted
pursuant to Section 3.01(c)  (it being understood that any and all interest
earned on funds made available to the Paying Agent pursuant to this
Agreement shall be turned over to Parent).

       (b)  Exchange Procedure.  As soon as reasonably practicable after the
Effective Time, the Paying Agent shall mail to each holder of record of a
certificate or certificates that immediately prior to the Effective Time
represented Shares (the "Certificates"), (i) a letter of transmittal (which
shall specify that delivery shall be effected, and risk of loss and title
to the Certificates shall pass, only upon delivery of the Certificates to
the Paying Agent and shall be in a form and have such other provisions as
Parent may reasonably specify) and (ii) instructions for use in effecting
the surrender of the Certificates in exchange for the Merger Consideration.
Upon surrender of a Certificate for cancelation to the Paying Agent or to
such other agent or agents as may be appointed by Parent, together with
such letter of transmittal, duly executed, and such other documents as may
reasonably be required by the Paying Agent, the holder of such Certificate
shall be entitled to receive in exchange therefor, and the Paying Agent
shall pay pursuant to irrevocable instructions given by Sub or Parent, the
amount of cash into which the Shares theretofore represented by such
Certificate shall have been converted pursuant to Section 3.01, and the
Certificate so surrendered shall forthwith be canceled.  In the event of a
transfer of ownership of Shares that is not registered in the transfer
records of the Company, payment may be made to a person other than the
person in whose name the Certificate so surrendered is registered, if such
Certificate shall be properly endorsed or otherwise be in proper form for
transfer and the person requesting such payment shall pay any transfer or
other taxes required by reason of the payment to a person other than the
registered holder of such Certificate or establish to the satisfaction of
the Surviving Corporation that such tax has been paid or is not applicable.
Until surrendered as contemplated by this Section 3.02, each Certificate
shall be deemed at any time after the Effective Time to represent only the
right to receive upon such surrender the amount of cash, without interest,
into which the Shares theretofore represented by such Certificate shall
have been converted pursuant to Section 3.01.  No interest will be paid or
will accrue on the cash payable upon the surrender of any Certificate.

       (c)  No Further Ownership Rights in Company Common Stock.  All cash
paid upon the surrender of Certificates in accordance with the terms of
this Article III shall be deemed to have been paid in full satisfaction of
all rights pertaining to the Shares theretofore represented by such
Certificates.  At the Effective Time, the stock transfer books of the
Company shall be closed, and there shall be no further registration of
transfers on the stock transfer books of the Surviving Corporation of the
Shares that were outstanding immediately prior to the Effective Time.  If,
after the Effective Time, Certificates are presented to the Surviving
Corporation or the Paying Agent for any reason, except notation thereon
that a stockholder has elected to exercise his right to appraisal pursuant
to the DGCL, they shall be canceled and exchanged as provided in this
Article III.

       (d)  No Liability.  Any funds deposited with the Paying Agent that
remain unclaimed by the former stockholders of the Company for six months
after the Effective Time shall be paid to the Surviving Corporation upon
demand, and any former stockholders of the Company who have not theretofore
complied with the instructions for exchanging their Certificates provided
herein shall thereafter look only to the Surviving Corporation for payment
of their claims for the Merger Consideration set forth in Section 3.01
hereof for each Share held by such stockholder, without any interest
thereon.  None of Parent, Sub, the Company or the Paying Agent shall be
liable to any person in respect of any cash delivered to a public official
pursuant to any applicable abandoned property, escheat or similar law.  If
any Certificates shall not have been surrendered prior to seven years after
the Effective Time (or immediately prior to such earlier date on which any
payment pursuant to this Article III would otherwise escheat to or become
the property of any Governmental Entity (as defined in Section 4.05)), the
cash payment in respect of such Certificate shall, to the extent permitted
by applicable law, become the property of the Surviving Corporation, free
and clear of all claims or interests of any person previously entitled
thereto.

       (e)  Lost, Stolen or Destroyed Certificates.  In the event any
Certificates evidencing Shares shall have been lost, stolen or destroyed, the
Paying Agent shall pay to such holder the Merger Consideration required
pursuant to Section 3.01, in exchange for such lost, stolen or destroyed
Certificates, upon the making of an affidavit of that fact by the holder
thereof with such assurances as the Paying Agent, in its discretion and as a
condition precedent to the payment of the Merger Consideration, may require of
the holder of such lost, stolen or destroyed Certificates.

       (f)  Withholding Rights.  Parent and the Surviving Corporation shall
be entitled to deduct and withhold from the consideration otherwise payable
pursuant to this Agreement such amounts as may be required to be deducted
and withheld with respect to the making of such payment under the Code, or
under any provision of state, local or foreign tax law; provided, however,
that Parent and the Surviving Corporation shall promptly pay any amounts
deducted and withheld hereunder to the applicable governmental authority,
shall promptly file all tax returns and reports required to be filed in
respect of such deductions and withholding, and shall promptly provide to
the Company proof of such payment and a copy of all such tax returns and
reports.


                                  ARTICLE IV

                 Representations and Warranties of the Company

       Except as disclosed in the SEC Documents (as defined in Section 4.06)
filed or publicly available prior to the date of this Agreement (the "Filed
SEC Documents") or set forth on the Disclosure Schedule delivered by the
Company to Parent prior to the execution of this Agreement (the "Company
Disclosure Schedule"), it being agreed that any matter disclosed in the
Company Disclosure Schedule with respect to any subsection of this Agreement
shall be deemed to have been disclosed with respect to all subsections of this
Agreement, the Company represents and warrants to Parent and Sub as follows:

       SECTION 4.01.  Organization.  Each of the Company and its subsidiaries
is a corporation, partnership, limited liability company or other company duly
organized, validly existing and in good standing under the laws of the
jurisdiction in which it is incorporated or organized and has all requisite
power and authority to carry on its business as now being conducted.  Each of
the Company and its subsidiaries is duly qualified or licensed to do business
and in good standing in each jurisdiction in which the property owned, leased
or operated by it or the nature of the business conducted by it makes such
qualification or licensing necessary, except in such jurisdictions where the
failure to be so duly qualified or licensed and in good standing individually
or in the aggregate would not reasonably be expected to have a material
adverse effect (as defined in Section 10.03) on the Company.  The Company has
made available to Parent complete and correct copies of its Certificate of
Incorporation and Bylaws, and the certificate of incorporation and bylaws or
other organizational documents of each of its subsidiaries, in each case as
amended to the date of this Agreement.

       SECTION 4.02.  Company Subsidiaries; Equity Interests.  (a)  Exhibit
21.1 to the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1997 lists each subsidiary of the Company.  All the outstanding
shares of capital stock of each subsidiary of the Company have been validly
issued and are fully paid and nonassessable and (with the exception, in the
case of certain non-U.S. subsidiaries, of shares held of record by nominees of
the Company) are owned by the Company, by another subsidiary of the Company or
by the Company and another subsidiary of the Company, free and clear of all
pledges, liens, charges, mortgages, encumbrances and security interests of any
kind or nature whatsoever (collectively, "Liens") and free of any other
restriction (including any restriction on the right to vote, sell or otherwise
dispose of such capital stock or other ownership interests).

       (b)  Except for its interests in its subsidiaries, the Company does not
own, directly or indirectly, any capital stock, membership interest,
partnership interest, limited liability interest, joint venture interest or
other ownership interest with a fair market value as of the date of this
Agreement in excess of $5,000,000 in any person.

       SECTION 4.03. Capitalization. The authorized capital stock of the Company
consists of 130,000,000 shares of Company Common Stock and 10,000,000 shares of
preferred stock, par value $1.00 per share ("Company Preferred Stock"). At the
close of business on June 30, 1998, (i) 98,816,286 Shares were issued and
outstanding, (ii) the Company did not hold any Shares in its treasury, (iii)
2,216,553 Shares were reserved for issuance upon exercise of outstanding Company
Stock Options under the Stock Option Plans (each as defined in Section 7.05),
(iv) 513,574 Shares were reserved for issuance pursuant to the Company's
Employee Stock Purchase Plan and (v) no shares of Company Preferred Stock were
issued and outstanding. Except as set forth above, since June 30, 1998, 7,964
shares of capital stock or other voting securities of the Company were issued,
and no other shares of such stock or securities were reserved for issuance,
issuable or outstanding. All outstanding Shares are, and all Shares which may be
issued will be, when issued in accordance with the terms of the agreements,
plans or other documents governing their issuance, duly authorized, validly
issued, fully paid and nonassessable and not subject to or issued in violation
of any purchase option, call option, right of first refusal, preemptive right,
subscription right or any similar right under any provision of the DGCL, the
Certificate of Incorporation or the Bylaws of the Company or any contract,
agreement, arrangement or understanding to which the Company is a party or
otherwise bound. There are no bonds, debentures, notes or other indebtedness of
the Company having the right to vote (or convertible into, or exchangeable for,
securities having the right to vote) on any matters on which stockholders of the
Company may vote. Except as set forth above, there are not any securities,
options, warrants, calls, rights, commitments, agreements, arrangements or
undertakings of any kind to which the Company or any of its subsidiaries is a
party or by which any of them is bound obligating the Company or any of its
subsidiaries to issue, deliver or sell, or cause to be issued, delivered or
sold, additional shares of capital stock or other voting securities of the
Company or any of its subsidiaries, or securities convertible into or
exercisable for or exchangeable into any such shares, or obligating the Company
to issue, grant, extend or enter into any such security, option, warrant, call,
right, commitment, agreement, arrangement or undertaking. There are not any
outstanding contractual obligations of the Company or any of its subsidiaries to
repurchase, redeem or otherwise acquire any shares of capital stock of the
Company or any of its subsidiaries. Neither the Company nor any of its
subsidiaries is a party to any voting agreement with respect to the voting of
any of its securities. The Shares set forth in Exhibit A to the Stockholder
Agreement represent in excess of 80% of the outstanding shares of Company Common
Stock on a fully diluted basis.

       SECTION 4.04.  Authority.  The Company has the requisite corporate
power and authority to execute and deliver this Agreement and to consummate
the transactions contemplated hereby (other than, with respect to the Merger,
the approval and adoption of this Agreement by the holders of a majority of
the Shares if required by law (the "Company Stockholder Approval")).  The
execution, delivery and performance of this Agreement and the consummation by
the Company of the Merger and of the other transactions contemplated hereby
have been duly authorized by all necessary corporate action on the part of the
Company and no other corporate proceedings on the part of the Company are
necessary to authorize this Agreement or to consummate the transactions so
contemplated (in each case, other than, with respect to the Merger, the
Company Stockholder Approval if required by law).  This Agreement has been
duly executed and delivered by the Company and, assuming this Agreement
constitutes a valid and binding obligation of Parent and Sub, constitutes a
valid and binding obligation of the Company enforceable against the Company in
accordance with its terms.

       SECTION 4.05.  Consents and Approvals;  No Violations.  Except for
filings, permits, authorizations, consents and approvals as may be required
under, and other applicable requirements of, the Exchange Act (including
the filing with the SEC of the Schedule 14D-9 and a proxy or information
statement relating to any required approval by or meeting of the Company's
stockholders with respect to this Agreement (the "Proxy Statement")), the
Merger Control Laws (as defined below), the DGCL and the laws of other
states in which the Company is qualified to do or is doing business,
neither the execution, delivery and performance of this Agreement by the
Company nor the consummation by the Company of the transactions
contemplated hereby will (i) conflict with or result in any breach of any
provision of the Certificate of Incorporation or the Bylaws of the Company,
(ii) require any filing with, or permit, authorization, consent or approval
of, any Federal, state or local government or any court, tribunal,
administrative agency or commission or other governmental or other
regulatory authority or agency, domestic, foreign or supranational (a
"Governmental Entity"), (iii) result in a violation or breach of, or
constitute (with or without due notice or lapse of time or both) a default
(or give rise to any right of termination, amendment, cancelation or
acceleration) under, any of the terms, conditions or provisions of any
note, bond, mortgage, indenture, lease, license, contract, agreement or
other instrument or obligation to which the Company or any of its
subsidiaries is a party or by which any of them or any of their properties
or assets may be bound or (iv) violate any order, writ, injunction, decree,
statute, rule or regulation applicable to the Company or any of its
subsidiaries or any of their properties or assets, except in the case of
clause (ii), (iii) and (iv) for failures, violations, breaches or defaults
that individually or in the aggregate would not reasonably be expected to
have a material adverse effect on the Company. "Merger Control Laws" means
(i) the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended
(the "HSR Act"), and (ii)  Council Regulation (EEC)  No. 4064/89 of 21
December 1989 and (iii) all amendments of, and all other applicable bills,
acts, decrees, regulations or ordinances relating to, the foregoing
legislative acts.

       SECTION 4.06.  SEC Documents; Financial Statements.  The Company has
filed with the SEC all reports, forms, schedules and statements and other
documents required to be filed by it since January 1, 1997 (the "SEC
Documents").  As of their respective filing dates, (i) the SEC Documents
complied in all material respects with the requirements of the Securities Act
of 1933, as amended (the "Securities Act"), or the Exchange Act, as the case
may be, and the rules and regulations of the SEC promulgated thereunder
applicable to such SEC Documents, and (ii) none of the SEC Documents contained
any untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary in order to make the statements
therein, in light of the circumstances under which they were made, not
misleading.  Except to the extent that information contained in any SEC
Document has been revised or superseded by a later-filed SEC Document, none of
the SEC Documents contains any untrue statement of a material fact or omits to
state any material fact required to be stated therein or necessary in order to
make the statements therein, in light of the circumstances under which they
were made, not misleading.  The financial statements of the Company included
in the SEC Documents comply as to form in all material respects with applicable
accounting requirements and the published rules and regulations of the SEC
with respect thereto, have been prepared in accordance with generally accepted
accounting principles (except, in the case of unaudited statements, as
permitted by Form 10-Q of the SEC) applied on a consistent basis during the
periods involved (except as may be indicated in the notes thereto) and fairly
present, in all material respects, the consolidated financial position of the
Company as of the dates thereof and the results of its operations and cash
flows for the periods then ended (subject, in the case of unaudited
statements, to normal year-end audit adjustments).  Except as set forth or
reflected in the most recent financial statements included in the Filed SEC
Documents, or incurred in the ordinary course of business consistent with past
practice since the date of such statements, neither the Company nor any of its
subsidiaries has any liabilities of any nature (whether accrued, absolute,
contingent or otherwise) which individually or in the aggregate would
reasonably be expected to have a material adverse effect on the Company.

       SECTION 4.07.  Information Supplied.  None of the information supplied
or to be supplied by the Company in writing for inclusion or incorporation by
reference in (i) the Offer Documents, (ii) the Schedule 14D-9, (iii) the
information to be filed by the Company in connection with the Offer pursuant
to Rule 14f-1 promulgated under the Exchange Act (the "Information Statement")
or (iv) the Proxy Statement will, in the case of the Offer Documents, the
Schedule 14D-9 and the Information Statement at the respective times the Offer
Documents, the Schedule 14D-9 and the Information Statement are filed with the
SEC or first published, sent or given to the Company's stockholders, or in the
case of the Proxy Statement, at the time the Proxy Statement is first mailed
to the Company's stockholders or at the time of the Stockholders Meeting (as
defined in Section 7.01), as such Proxy Statement may be amended or
supplemented, contain any untrue statement of a material fact or omit to state
any material fact required to be stated therein or necessary in order to make
the statements therein, in light of the circumstances under which they are
made, not misleading.  The Schedule 14D-9, the Information Statement and the
Proxy Statement will comply as to form in all material respects with the
requirements of the Exchange Act and the rules and regulations thereunder,
except that no representation or warranty is made by the Company with respect
to statements made or incorporated by reference therein based on written
information supplied by Parent or Sub specifically for inclusion or
incorporation by reference therein.

       SECTION 4.08.  Absence of Certain Changes or Events.  Since the date of
the most recent financial statements included in the Filed SEC Documents, the
Company and its subsidiaries have conducted their respective businesses only
in the ordinary course consistent with past practice, and there has not been
(i) any material adverse change (as defined in Section 10.03) in the Company,
(ii) any declaration, setting aside or payment of any dividend or other
distribution (whether in cash, stock or property) with respect to any of the
Company's capital stock, (iii) any split, combination or reclassification of
any of its capital stock or any issuance or the authorization of any issuance
of any other securities in respect of, in lieu of or in substitution for
shares of its capital stock, (iv) (x) any granting by the Company or any of
its subsidiaries to any director, officer or key employee (as defined below)
of any increase in compensation, except in the ordinary course of business
consistent with past practice or as was required under employment agreements in
effect as of the date of the most recent financial statements included in the
Filed SEC Documents, (y) any granting by the Company or any of its
subsidiaries to any director, officer or key employee of any increase in
severance or termination pay, except as was required under any employment,
severance or termination agreements in effect as of the date of the most
recent financial statements included in the Filed SEC Documents or (z) any
entry by the Company or any of its subsidiaries into, or amendment of, any
employment, severance or termination agreement with any director, officer or
key employee, (v) any damage, destruction or loss to property, whether or not
covered by insurance, that individually or in the aggregate has or would
reasonably be expected to have a material adverse effect on the Company, (vi)
any change in accounting methods, principles or practices by the Company
materially affecting its assets, liabilities or business, except insofar as
may have been required by a change in generally accepted accounting principles
or (vii) any tax election that individually or in the aggregate would
reasonably be expected to have a material adverse effect on the Company.

       SECTION 4.09.  Litigation.  There is no suit, action or proceeding
pending or, to the knowledge of the Company, threatened against the Company or
any of its subsidiaries that individually or in the aggregate would reasonably
be expected to have a material adverse effect on the Company, nor is there any
judgment, decree, injunction, rule or order of any Governmental Entity or
arbitrator outstanding against the Company having, or which would reasonably
be expected to have, any such effect.

       SECTION 4.10.  Contracts.  (a)  There are no contracts or agreements
that are material contracts (as defined in Securities Act Regulation
601(b)(10)) with respect to the Company and its subsidiaries taken as a whole.
Neither the Company nor any of its subsidiaries is in violation of or in
default under (nor does there exist any condition which upon the passage of
time or the giving of notice or both would cause such a violation of or default
under) any lease, permit, concession, franchise, license or any other contract
or agreement to which it is a party or by which it or any of its properties or
assets is bound, except for violations or defaults that individually or in the
aggregate would not reasonably be expected to result in a material adverse
effect on the Company.

       (b)  Section 4.10(b) of the Company Disclosure Schedule sets forth a
complete list of each contract or agreement to which the Company or any of its
subsidiaries is a party or bound (x) with any affiliate of the Company other
than any direct or indirect wholly-owned subsidiary of the Company or (y) that
includes any non-competition or similar provisions.  The Company has made
available to Parent and its representatives true and correct copies of all the
agreements, contracts and arrangements set forth in Section 4.10(b) of the
Company Disclosure Schedule.

       SECTION 4.11.  Compliance with Laws.  Each of the Company and its
subsidiaries is in compliance with all applicable statutes, laws, ordinances,
regulations, rules, judgments, decrees and orders of any Governmental Entity
applicable to its business or operations, except for instances of actual or
possible noncompliance that individually or in the aggregate would not
reasonably be expected to have a material adverse effect on the Company.  Each
of the Company and its subsidiaries has in effect all Federal, state, local
and foreign governmental approvals, authorizations, certificates, filings,
franchises, licenses, notices, permits and rights, including all authorizations
under Environmental Laws (as defined in Section 4.12(a)) ("Permits"),
necessary for it to own, lease or operate its properties and assets and to
carry on its business as now conducted, except for the failure to have such
Permits that individually or in the aggregate would not reasonably be expected
to have a material adverse effect on the Company.  There has occurred no
default under any Permit, except for defaults under Permits that individually
or in the aggregate would not reasonably be expected to have a material adverse
effect on the Company.  No investigation or review by any Governmental Entity
with respect to the Company or any of its subsidiaries is pending or, to the
best knowledge of the Company, threatened, nor has any Governmental Entity
indicated an intention to conduct any investigation or review, other than, in
each case, those the outcome of which individually or in the aggregate would
not reasonably be expected to have a material adverse effect on the Company.

       SECTION 4.12.  Environmental Matters.  (a)  Each of the Company and its
subsidiaries is, and has been, in compliance with all applicable Environmental
Laws, except for actual or possible noncompliance which individually or in the
aggregate would not reasonably be expected to have a material adverse effect
on the Company.  The term "Environmental Laws" means any Federal, state,
provincial, regional, municipal, local or foreign judgment, order, decree,
statute, law, ordinance, rule, regulation, code, permit, consent, approval,
license, writ, decree, directive, injunction or other enforceable requirement,
including any registration requirement, relating to:  (A) Releases (as defined
below) or threatened Releases of Hazardous Materials (as defined below) into
the environment; (B) the generation, treatment, storage, disposal, use,
handling, manufacturing, transportation or shipment of Hazardous Materials; or
(C) otherwise relating to pollution or protection of health or safety or the
environment.

       (b)  There has been no Release or threatened Release of Hazardous
Materials, in, on, under or affecting any property owned, leased or operated
by the Company or any of its subsidiaries or, to the knowledge of the Company,
any adjacent site or any property previously owned, leased or operated by the
Company or any of its subsidiaries, except in each case for those Releases
which individually or in the aggregate would not reasonably be expected to
have a material adverse effect on the Company.  The term "Release" has the
meaning set forth in 42 U.S.C. Section  9601(22).  The term "Hazardous
Materials" means any pollutant, contaminant, hazardous, radioactive or toxic
substance, material, constituent or waste, or any other waste, substance,
chemical or material regulated under any Environmental Law, including (1)
petroleum, crude oil and any fractions thereof, (2) natural gas, synthetic gas
and any mixtures thereof, (3) asbestos or asbestos-containing material, (4)
radon and (5) polychlorinated biphenyls ("PCBs"), or materials or fluids
containing PCBs.

       (c)  Neither the Company nor any of its subsidiaries has received any
written or, to the knowledge of the Company, oral notice of a pending or
threatened action, demand, investigation or inquiry by any Governmental Entity
or other person relating to any actual or potential violations of
Environmental Law or any actual or potential obligation to investigate or
remediate a Release or threatened Release of any Hazardous Materials.

       (d)  Neither the Company nor any of its subsidiaries has assumed,
whether by contract or, to the Company's knowledge based on written
notification or opinion of counsel, operation of law, any liabilities or
obligations arising under Environmental Laws in connection with formerly
owned, leased or operated properties or facilities or in connection with any
formerly owned divisions, subsidiaries, companies or other entities, except in
each case for those which individually or in the aggregate would not reasonably
be expected to have a material adverse effect on the Company.

       SECTION 4.13.  Absence of Changes in Benefit Plans; Labor Relations.
Since the date of the most recent financial statements included in the Filed
SEC Documents, there has not been any adoption or amendment in any material
respect by the Company or any of its subsidiaries of any employment contract,
collective bargaining agreement or any bonus, pension, profit sharing,
deferred compensation, incentive compensation, stock ownership, stock purchase,
stock option, phantom stock, retirement, vacation, severance, disability,
death benefit, hospitalization, medical or other plan or arrangement providing
benefits to any current or former employee, officer or director of the Company
or any of its subsidiaries.  There exist no employment, consulting, severance,
termination or indemnification agreements or arrangements between the Company
or any of its subsidiaries and any current or former key employee, officer or
director of the Company or any of its subsidiaries.  There are no collective
bargaining or other labor union agreements to which the Company or any of its
subsidiaries is a party or by which the Company or any of its subsidiaries is
bound.  To the best knowledge of the Company, since January 1, 1997, neither
the Company nor any of its subsidiaries has encountered any labor union
organizing activity, or had any actual or threatened employee strikes, work
stoppages, slowdowns or lockouts.

       SECTION 4.14.  ERISA Compliance.  (a)  Schedule 4.14(a) to the Company
Disclosure Schedule contains a list of all "employee pension benefit plans"
(as defined in Section 3(2) of the Employee Retirement Income Security Act of
1974, as amended ("ERISA")) (sometimes referred to herein as "Pension Plans"),
severance, termination or change in control plans and all other stock option,
stock purchase, equity based, deferred compensation or incentive plans or
programs (in each case, whether or not subject to ERISA) maintained or
contributed to by the Company, any of its subsidiaries or any other person or
entity that, together with the Company and its subsidiaries, is treated as a
single employer under Section 414(b), (c), (m) or (o) of the Code (the Company
and each such other person or entity, a "Commonly Controlled Entity") for the
benefit of any current or former employees, officers or directors of the
Company or any of its subsidiaries (collectively, "Benefit Plans").  The
Company has delivered or made available to Parent true, complete and correct
copies of (i) each Benefit Plan (or, in the case of any unwritten Benefit
Plans, descriptions thereof), (ii) the most recent annual report on Form 5500
filed with the Internal Revenue Service with respect to each Benefit Plan (if
any such report was required), (iii) the most recent summary plan description
for each Benefit Plan for which such summary plan description is required,
(iv) the most recent financial or actuarial valuation prepared with respect to
any Benefit Plan and (v) each trust agreement and group annuity contract
relating to any Benefit Plan.  Each Benefit Plan has been administered in all
material respects in accordance with its terms.  Each of the Company and its
subsidiaries and all the Benefit Plans are all in compliance in all material
respects with applicable provisions of ERISA, the Code and all other
applicable laws, rules or regulations.

       (b)  All Pension Plans intended to qualify under Section 401(a) of the
Code have been the subject of determination letters from the Internal Revenue
Service to the effect that such Pension Plans are qualified and exempt from
Federal income taxes under Section 401(a) and 501(a), respectively, of the
Code, and no such determination letter has been revoked nor has any such
Pension Plan been amended since the date of its most recent determination
letter or application therefor in any respect that would adversely affect its
qualification or materially increase its costs.  All amendments to Pension
Plans required under ERISA and the Code to be adopted by the Company by the
date of this Agreement have been adopted.

       (c)  Neither the Company nor its subsidiaries has within the five-year
period immediately preceding the date of this Agreement maintained,
contributed to or been obligated to contribute to any Benefit Plan that is
subject to Title IV of ERISA.  Neither the Company nor its subsidiaries is
required to contribute to any "multiemployer plan" (as defined in Section
4001(a)(3) of ERISA) or has withdrawn from any multiemployer plan where such
withdrawal has resulted or would result in any "withdrawal liability" (within
the meaning of Section 4201 of ERISA) that has not been fully paid.  There is
no material unsatisfied liability with respect to any Benefit Plan.  No event
has occurred with respect to any Pension Plan, other than a Benefit Plan,
maintained or contributed to by any Commonly Controlled Entity which has
resulted or will likely result in the Company or any of its subsidiaries
becoming subject to liability under Title IV of ERISA or the minimum funding
requirements of Section 412 of the Code or Part 3 of Title I of ERISA,
including withdrawal liability with respect to any multiemployer plan.

       (d)  With respect to any plan that is an employee welfare benefit plan
of the Company or its subsidiaries, (i) no such plan provides post-retirement
benefits to former employees and (ii) there are no understandings, agreements
or undertakings, written or oral, that would prevent any such plan (including
any such plan covering retirees or other former employees) from being amended
or terminated without material liability to the Company on or at any time
after the Effective Time.

       (e)  Schedule 4.14(e) to the Company Disclosure Schedule lists all
outstanding Stock Options as of June 30, 1998, showing for each such Option:
(i) the number of Shares issuable, (ii) the number of vested Shares, (iii) the
date of grant and (iv) the exercise price.

       (f)  No employee of the Company or any of its subsidiaries will be
entitled to any additional compensation or benefits or any acceleration of the
time of payment or vesting of any compensation or benefits under any Benefit
Plan as a result of the transactions contemplated by this Agreement.  Any
equity-related, bonus or incentive compensation program maintained by the
Company or its subsidiaries to provide payments or benefits to any current or
former employee or director of the Company or any of its subsidiaries
satisfies the requirements of Section 162(m) of the Code.  Actions taken by
Parent or the Company after the Effective Time shall not be taken into account
for purposes of the preceding sentence.

       (g)  There are no pending or, to the knowledge of the Company,
threatened claims, suits, investigations or audits involving the Benefit Plans
(other than claims for benefits in the ordinary course).

       (h)  As a result of the transactions contemplated by this Agreement, no
current or former employee or director of the Company or any of its
subsidiaries shall be eligible for compensation or benefits duplicative of
those provided or made available as a result of the acquisition of the shares
of Corange Limited by an indirect wholly-owned subsidiary of Roche Holding Ltd
in March, 1998.

       SECTION 4.15.  Taxes.  (a)  Each of the Company and its subsidiaries
has filed all tax returns and reports required to be filed by it, which tax
returns and reports are true, complete and accurate in all material respects,
and has paid all material taxes due and required to be paid by it, and the
most recent financial statements contained in the Filed SEC Documents reflect
an adequate reserve for all taxes payable by the Company and its subsidiaries
for all taxable periods and portions thereof through the date of such
financial statements.  No deficiencies for any taxes which remain outstanding
have been proposed, asserted or assessed against the Company or any of its
subsidiaries, and no requests for waivers of the time to assess any such taxes
are pending. Neither the Company nor any of its subsidiaries has or will have
any material liability with respect to taxes of any person (other than the
Company or any of its subsidiaries) which, immediately prior to the
consummation of the Offer,  is an affiliate of the Company or of any of its
subsidiaries.

       (b)  The Federal consolidated income tax returns of the Company and
each of its affiliates that have joined in the filing of such returns have
been examined by and settled with the United States Internal Revenue Service
for all years through the year ended December 31, 1992.  The statute of
limitations on assessment or collection of any Federal income taxes due from
the Company or any other members of the affiliated group with which the
Company files Federal consolidated income tax returns has expired for all
taxable years of the Company and such group through the year ended December
31, 1992.

       (c)  Section 4.15 of the Company Disclosure Schedule sets forth a
complete list of each tax sharing agreement, tax indemnity obligation or
similar agreement or arrangement with respect to taxes pursuant to which the
Company or any of its subsidiaries would have any material obligation after
the date of this Agreement.

       (d)  As used in this Agreement, "taxes" shall mean all Federal, state,
local and foreign income, franchise, property, sales, excise, employment,
payroll, social security, value-added, ad valorem, transfer, withholding and
other taxes, tariffs, levies, impositions, assessments or other governmental
charges in the nature of a tax as well as any interest, penalties and
additions to tax.

       SECTION 4.16.  No Excess Parachute Payments.  No amount that would be
received, or benefit provided, in connection with any of the transactions
contemplated by this Agreement by any employee, officer or director of the
Company or any of its subsidiaries who is a "disqualified individual" (as such
term is defined in proposed Treasury Regulation Section 1.280G-1) under any
employment, severance or termination agreement, other compensation arrangement
or Benefit Plan currently in effect would be an "excess parachute payment" (as
such term is defined in Section 280G(b)(1) of the Code).  To the best
knowledge of the Company, no disqualified individual is entitled to receive
any additional payment from the Company or any of its subsidiaries, the
Surviving Corporation, or any other person referred to in Q&A 10 under
proposed Treasury Regulation Section 1.280G-1 (a "Parachute Gross-Up Payment")
in the event that the excise tax of Section 4999(a) of the Code is imposed on
such person.  The Board of Directors of the Company has not during the six
months prior to the date of this Agreement granted to any officer, director or
employee of the Company any right to receive any Parachute Gross-Up Payment.

       SECTION 4.17.  Title to Properties.  (a)  Each of the Company and its
subsidiaries has good and marketable title to, or valid leasehold interests in
or valid rights to, all its material properties and assets except for such as
are no longer used or useful in the conduct of its businesses or as have been
disposed of in the ordinary course of business and except for defects in title,
easements, restrictive covenants and similar encumbrances that individually or
in the aggregate do not materially interfere with its ability to conduct its
business as currently conducted.  All such material assets and properties,
other than assets and properties in which the Company or any of its
subsidiaries has a leasehold interest, are free and clear of all Liens except
for Liens that individually or in the aggregate do not materially interfere
with the ability of the Company and its subsidiaries to conduct their
respective businesses as currently conducted.

       (b)  Each of the Company and its subsidiaries has complied in all
material respects with the terms of all material leases to which it is a party
and under which it is in occupancy, and all such leases are in full force and
effect.  Each of the Company and its subsidiaries enjoys peaceful and
undisturbed possession under all such material leases, except for failures to
do so that individually or in the aggregate would not reasonably be expected
to have a material adverse effect on the Company.

       SECTION 4.18.  Intellectual Property.  Each of the Company and its
subsidiaries owns, or is validly licensed or otherwise has the right to use,
without any obligation to make any fixed or contingent payments, including any
royalty payments, all patents, patent rights, trademarks, trademark rights,
trade names, trade name rights, service marks, service mark rights, copyrights
and other proprietary intellectual property rights and computer programs
(certain of which computer programs may require royalty payments) that are
material to the conduct of its business as now operated (collectively,
"Intellectual Property Rights").  Schedule 4.18 to the Company Disclosure
Schedule sets forth a description of all patents, trademarks and copyrights and
applications therefor owned by or licensed to the Company or any of its
subsidiaries that are material to the conduct of the business of the Company
or any of its subsidiaries as now operated.  No claims are pending or, to the
knowledge of the Company, threatened that the Company or any of its
subsidiaries is infringing or otherwise adversely affecting the rights of any
person with regard to any Intellectual Property Right.  To the knowledge of
the Company, no person is infringing the rights of the Company or any of its
subsidiaries with respect to any Intellectual Property Right.  Neither the
Company nor any of its subsidiaries has licensed, or otherwise granted, to any
third party, any rights in or to any Intellectual Property Rights.

       SECTION 4.19.  Agreements for Distribution Outside the United States.
Schedule 4.19 to the Company Disclosure Schedule is a complete list of all
material contracts or agreements to which the Company or any of its
subsidiaries is a party, other than contracts between the Company and its
wholly-owned subsidiaries or between wholly-owned subsidiaries of the Company,
relating to the distribution, sale or marketing outside of the United States
by third parties of the products of, or products licensed by, the Company or
any of its subsidiaries.  The Company has made available to Parent and its
representatives true and correct copies of all contracts and agreements to
which the Company or any of its subsidiaries is a party relating to the
distribution, sale or marketing outside of the United States by third parties
of the products of, or products licensed by, the Company or any of its
subsidiaries.

       SECTION 4.20.  Voting Requirements.  The affirmative vote of the
holders of a majority of the outstanding Shares is the only vote of the
holders of any class or series of the Company's capital stock necessary to
approve this Agreement and the transactions contemplated by this Agreement.

       SECTION 4.21.  State Takeover Statutes.  The Board of Directors of the
Company has approved the Merger, this Agreement and the Stockholder Agreement,
and such approval is sufficient to render inapplicable to the Merger, this
Agreement, the Stockholder Agreement, and the transactions contemplated by
this Agreement and the Stockholder Agreement, the provisions of Section 203 of
the DGCL.

       SECTION 4.22.  Brokers; Schedule of Fees and Expenses.  No broker,
investment banker, financial advisor or other person, other than Bear,
Stearns, the fees and expenses of which will be paid by the Company, is
entitled to any broker's, finder's, financial advisor's or other similar fee
or commission in connection with the transactions contemplated by this
Agreement based upon arrangements made by or on behalf of the Company.  Such
fees and expenses incurred and to be incurred in connection with this
Agreement and the transactions contemplated by this Agreement (other than
printing and mailing costs and expenses), including the fees and expenses of
Bear, Stearns, shall be as set forth on Schedule 4.22 to the Company
Disclosure Schedule.

       SECTION 4.23.  Opinion of Financial Advisor.  The Board of Directors of
the Company has received the opinion of Bear, Stearns that, as of such date
and based upon and subject to the matters set forth therein, the cash
consideration to be received by holders of Shares pursuant to the Offer and
the Merger was fair from a financial point of view to such holders, a signed
copy of which opinion has been delivered to Parent.


                                   ARTICLE V

                        Representations and Warranties
                               of Parent and Sub

       Parent and Sub represent and warrant to the Company as follows:

       SECTION 5.01.  Organization.  Each of Parent and Sub is a corporation
duly organized, validly existing and in good standing under the laws of the
jurisdiction of its incorporation and has all requisite corporate power and
authority to carry on its business as now being conducted.  Each of Parent and
Sub is duly qualified or licensed to do business and is in good standing in
each jurisdiction in which the nature of its business or the ownership or
leasing of its properties makes such qualifications or licensing necessary,
other than in such jurisdictions where the failure to be so qualified or
licensed individually or in the aggregate would not reasonably be expected to
prevent or materially delay the consummation of the Offer or the Merger.
Parent has made available to the Company complete and correct copies of its
certificate of incorporation and bylaws and the certificate of incorporation
and bylaws of Sub, in each case as amended to the date of this Agreement.

       SECTION 5.02.  Authority.  Parent and Sub have the requisite corporate
power and authority to execute and deliver this Agreement and the Stockholder
Agreement, and to consummate the transactions contemplated by this Agreement
and the Stockholder Agreement.  The execution, delivery and performance of
this Agreement and the Stockholder Agreement, and the consummation of the
transactions contemplated by this Agreement and the Stockholder Agreement,
have been duly authorized by all necessary corporate action on the part of
Parent and Sub and no other corporate proceedings on the part of Parent and
Sub are necessary to authorize this Agreement or the Stockholder Agreement or
to consummate the transactions contemplated hereby or thereby.  No vote of
Parent stockholders is required to approve this Agreement or the Stockholder
Agreement or the transactions contemplated hereby or thereby.  Each of this
Agreement and the Stockholder Agreement has been duly executed and delivered
by Parent and Sub, and, assuming each such agreement constitutes a valid and
binding obligation of the other parties thereto, constitutes a valid and
binding obligation of Parent and Sub enforceable against Parent and Sub in
accordance with its terms.

       SECTION 5.03.  Consents and Approvals; No Violations.  Except for
filings, permits, authorizations, consents and approvals as may be required
under, and other applicable requirements of, the Exchange Act (including the
filing with the SEC of the Offer Documents), the Merger Control Laws, the DGCL
and the laws of other states in which Parent is qualified to do or is doing
business, neither the execution, delivery and performance of this Agreement and
the Stockholder Agreement by Parent and Sub, nor the consummation by Parent
and Sub of the transactions contemplated hereby and thereby will (i) conflict
with or result in any breach of any provision of the respective certificate of
incorporation or bylaws of Parent and Sub, (ii) require any filing with, or
permit, authorization, consent or approval of, any Governmental Entity, (iii)
result in a violation or breach of, or constitute (with or without due notice
or lapse of time or both) a default (or give rise to any right of termination,
amendment, cancelation or acceleration) under, any of the terms, conditions or
provisions of any note, bond, mortgage, indenture, lease, license, contract,
agreement or other instrument or obligation to which Parent or any of its
subsidiaries is a party or by which any of them or any of their properties or
assets may be bound or (iv) violate any order, writ, injunction, decree,
statute, rule or regulation applicable to Parent or any of its subsidiaries or
any of their properties or assets, except in the case of clauses (ii), (iii)
and (iv) for violations, breaches or defaults that individually or in the
aggregate would not reasonably be expected to prevent or materially delay the
consummation of the Offer or the Merger.

       SECTION 5.04.  Information Supplied.  None of the information supplied
or to be supplied by Parent or Sub in writing for inclusion or incorporation
by reference in (i) the Offer Documents, (ii) the Schedule 14D-9, (iii) the
Information Statement or (iv) the Proxy Statement will, in the case of the
Offer Documents, the Schedule 14D-9 and the Information Statement, at the
respective times the Offer Documents, the Schedule 14D-9 and the Information
Statement are filed with the SEC or first published, sent or given to the
Company's stockholders, or, in the case of the Proxy Statement, at the time
the Proxy Statement is first mailed to the Company's stockholders or at the
time of the Stockholders Meeting, as such Proxy Statement may be amended or
supplemented, contain any untrue statement of a material fact or omit to state
any material fact required to be stated therein or necessary in order to make
the statements therein, in light of the circumstances under which they are
made, not misleading.  The Offer Documents will comply as to form in all
material respects with the requirements of the Exchange Act and the rules and
regulations thereunder, except that no representation or warranty is made by
Parent or Sub with respect to statements made or incorporated by reference
therein based on written information supplied by the Company specifically for
inclusion or incorporation by reference therein.

       SECTION 5.05.  Interim Operations of Sub.  Sub (and any other
wholly-owned subsidiary of Parent which may be used to effect the Offer and
the Merger pursuant to Section 2.01) was formed solely for the purpose of
engaging in the transactions contemplated hereby, has engaged in no other
business activities and has conducted its operations only as contemplated
hereby.

       SECTION 5.06.  Brokers.  No broker, investment banker, financial
advisor or other person, other than Credit Suisse First Boston Corporation,
the fees and expenses of which will be paid by Parent, is entitled to any
broker's, finder's, financial advisor's or other similar fee or commission in
connection with the transactions contemplated by this Agreement based upon
arrangements made by or on behalf of Parent or Sub.

       SECTION 5.07.  Financing.  At the expiration of the Offer and at the
Effective Time, Parent and Sub will have available all the funds necessary to
purchase all the Shares pursuant to the Offer and the Merger and to pay all
fees and expenses payable by Parent or Sub related to the transactions
contemplated by this Agreement.


                                  ARTICLE VI

                                   Covenants

       SECTION 6.01.  Conduct of Business.  During the period from the date of
this Agreement to the Effective Time or termination of this Agreement pursuant
to Section 9.01 hereof, except as otherwise contemplated hereby or to the
extent that Parent shall otherwise consent in writing, the Company shall, and
shall cause each of its subsidiaries to, carry on its business in the ordinary
course consistent with past practice and, to the extent consistent therewith,
use reasonable efforts to preserve intact its current business organization,
keep available the services of its current officers and employees and preserve
its relationships with customers, suppliers, licensors, licensees,
distributors and others having significant business dealings with it.  Without
limiting the generality of the foregoing, during the period from the date of
this Agreement to the Effective Time, the Company shall not, and shall not
permit any of its subsidiaries to (except as expressly permitted by this
Agreement or as set forth in Schedule 6.01 to the Company Disclosure Schedule
or to the extent that Parent shall otherwise consent in writing):

                (i) other than dividends and distributions by a direct or
            indirect wholly-owned subsidiary of the Company to its parent,
            (x) declare, set aside or pay any dividends on, or make any
            other distributions in respect of, any of its capital stock,
            (y) split, combine or reclassify any of its capital stock or
            issue or authorize the issuance of any other securities in
            respect of, in lieu of or in substitution for shares of its
            capital stock, or (z) purchase, redeem or otherwise acquire any
            shares of its capital stock or any other securities thereof or
            any rights, warrants or options to acquire any such shares or
            other securities;

               (ii) issue, deliver, sell, pledge or otherwise encumber any
            shares of its capital stock, any other voting securities or any
            securities convertible into, or any rights, warrants or options to
            acquire, any such shares, voting securities or convertible
            securities (other than the issuance of shares of Company Common
            Stock upon the exercise of Company Stock Options outstanding on
            the date of this Agreement in accordance with their present terms);

              (iii) amend its Certificate of Incorporation or Bylaws or other
            comparable charter or organizational documents;

               (iv) acquire or agree to acquire (A) by merging or
            consolidating with, or by purchasing a substantial portion of the
            assets or any stock of, or by any other manner, any business or
            any corporation, partnership, joint venture, association or other
            business organization or division thereof or (B) except as set
            forth on Schedule 6.01(iv) to the Company Disclosure Schedule, any
            assets that are material, individually or in the aggregate, to the
            Company, except purchases of inventory in the ordinary course of
            business consistent with past practice;

                (v) sell, lease, license, mortgage or otherwise encumber or
            subject to any Lien or otherwise dispose of any of its properties or
            assets, except sales of inventory or sales or licenses of immaterial
            assets, in each case in the ordinary course of business consistent
            with past practice;

               (vi) (y) incur any indebtedness for borrowed money or guarantee
            any such indebtedness of another person, issue or sell any debt
            securities or warrants or other rights to acquire any debt
            securities of the Company or any of its subsidiaries, guarantee
            any debt securities of another person, enter into any "keep well"
            or other agreement to maintain any financial statement condition
            of another person or enter into any arrangement having the
            economic effect of any of the foregoing, except for short-term
            borrowings incurred in the ordinary course of business consistent
            with past practice, or (z) make any loans, advances (other than to
            employees of the Company in the ordinary course of business) or
            capital contributions to, or investments in, any other person;

               (vii) except as set forth on Schedule 6.01(vii) to the Company
            Disclosure Schedule, make or agree to make any capital expenditure
            or expenditures with respect to property, plant or equipment which
            exceeds in the aggregate (a) with respect to the year ended
            December 31, 1998, 110% of the amount set forth in the Company's
            capital budget for such year, (b) with respect to any quarterly
            period thereafter, 25% of the amount in (a) above, and (c) $10
            million for a new computer system in the United Kingdom;

               (viii) make any material tax election or settle or compromise
            any material income tax liability or, except as required by
            generally accepted accounting principles, make any change in
            accounting methods, principles or practices;

               (ix) pay, discharge, settle or satisfy any material claims,
            liabilities or obligations (absolute, accrued, asserted or
            unasserted, contingent or otherwise), other than the payment,
            discharge or satisfaction, in the ordinary course of business
            consistent with past practice or in accordance with their terms, of
            liabilities reflected or reserved against in, or contemplated by,
            the most recent consolidated financial statements (or the notes
            thereto) of the Company included in the Filed SEC Documents or
            incurred thereafter in the ordinary course of business consistent
            with past practice, or waive any material benefits of, or agree to
            modify in any material respect, any confidentiality, standstill or
            similar agreements to which the Company or any of its subsidiaries
            is a party;

                (x) except in the ordinary course of business, modify, amend or
            terminate any material contract or agreement to which the Company or
            any of its subsidiaries is a party, or waive, release or assign any
            material rights or claims;

               (xi) enter into any material contracts or agreements relating
            to the distribution, sale or marketing by third parties of the
            products of, or products licensed by, the Company or any of its
            subsidiaries;

               (xii) except as required to comply with applicable law or
            agreements, plans or arrangements existing on the date hereof or
            as set forth in Schedule 6.01(xii) of the Company Disclosure
            Schedule, (A) adopt, enter into, terminate or amend any employment
            agreement or Benefit Plan or other arrangement for the benefit or
            welfare of any director, officer or current or former employee,
            (B) increase in any manner the compensation or fringe benefits of,
            or pay any bonus to, any director, officer or key employee (except
            for normal increases of cash compensation or cash bonuses to
            individuals (and not across the board actions), in the ordinary
            course of business consistent with past practice), (C) pay any
            benefit not provided for under any Benefit Plan, (D) except as
            permitted in clause (B), grant any awards under any bonus,
            incentive, performance or other compensation plan or arrangement
            or Benefit Plan (including the grant of stock options, stock
            appreciation rights, stock based or stock related awards,
            performance units or restricted stock, or the removal of existing
            restrictions in any Benefit Plans or agreement or awards made
            thereunder) or (E) take any action other than in the ordinary
            course of business to fund or in any other way secure the payment
            of compensation or benefits under any employee plan, agreement,
            contract or arrangement or Benefit Plan; or

               (xiii) authorize any of, or commit or agree to take any of, the
            foregoing actions.

       SECTION 6.02.  No Solicitation.  (a)  The Company shall not, and shall
not authorize or permit any of its subsidiaries or any of its or their
officers, directors or employees to, and shall use its reasonable efforts to
cause any investment banker, financial advisor, attorney, accountant or other
representative of the Company or of any of its subsidiaries not to, directly
or indirectly, (i) solicit, initiate or encourage (including by way of
furnishing information), or take any other action to facilitate, any inquiries
or the making of any proposal that constitutes, or may reasonably be expected
to lead to, any Takeover Proposal (as defined below) or (ii) participate in
any discussions or negotiations regarding any Takeover Proposal.  For purposes
of this Agreement, "Takeover Proposal" means any proposal or offer from any
person relating to any direct or indirect acquisition or purchase of 20% or
more of the assets of the Company and its subsidiaries, taken as a whole, or
20% or more of any class of outstanding equity securities of the Company or
any of its subsidiaries, any tender offer or exchange offer that if
consummated would result in any person beneficially owning 20% or more of any
class of equity securities of the Company or any of its subsidiaries or any
merger, consolidation, business combination, sale of substantially all the
assets, recapitalization, liquidation, dissolution or similar transaction
involving the Company or any of its subsidiaries, other than the transactions
contemplated by this Agreement.

       (b)  Neither the Board of Directors of the Company nor any committee
thereof shall (i) withdraw or modify, or propose to withdraw or modify, in a
manner adverse to Parent, the approval or recommendation by such Board of
Directors or such committee of the Offer, this Agreement or the Merger, (ii)
approve or recommend, or propose to approve or recommend, any Takeover
Proposal or (iii) cause the Company to enter into any letter of intent,
agreement in principle, acquisition agreement or other agreement (an
"Acquisition Agreement") with respect to any Takeover Proposal.

       (c)  In addition to the obligations of the Company set forth in
paragraphs (a) and (b) of this Section 6.02, the Company shall immediately
advise Parent orally and in writing of any Takeover Proposal, any request for
information concerning the Company or its subsidiaries in relation to or any
inquiry regarding the making of a Takeover Proposal, the material terms and
conditions of such Takeover Proposal, request for information or inquiry and
the identity of the person making such Takeover Proposal, request for
information or inquiry.  The Company will keep Parent fully informed of the
status and details (including amendments or proposed amendments) of any such
Takeover Proposal, request for information or inquiry.

       (d)  Nothing contained in this Section 6.02 shall prohibit the Company
from at any time taking and disclosing to its stockholders a position
contemplated by Rule 14d-9 or Rule 14e-2(a) promulgated under the Exchange
Act; provided, however, neither the Company nor its Board of Directors nor any
committee thereof shall withdraw or modify, or propose to withdraw or modify,
its position with respect to the Offer, the Merger or this Agreement or
approve or recommend, or propose to approve or recommend, a Takeover Proposal.

       SECTION 6.03.  Certain Tax Matters.  From the date hereof until the
Effective Time, (i) the Company and each of its subsidiaries will timely file
all tax returns and reports ("Post-Signing Returns") required to be filed (in
each case, at the Company's own cost and expense and in a manner that is
consistent with past practice and that is not likely to materially defer
income to a tax period that ends after the Closing Date or to materially
accelerate deductions to a tax period that ends on or before the Closing Date,
except to the extent that any such deferral of income or acceleration of
deductions is required by applicable law); (ii) the Company and each of its
subsidiaries will timely pay all taxes shown as due and payable on their
Post-Signing Returns that are so filed; (iii) the Company and each of its
subsidiaries will make provision for all taxes payable by the Company and each
of its subsidiaries for which no Post-Signing Return is due prior to the
Effective Time; and (iv) the Company will promptly notify Parent of any
action, suit, proceeding, claim or audit pending against or with respect to the
Company or any of its subsidiaries in respect of any tax where there is a
possibility of a determination or decision which would reasonably be expected
to have a significant adverse effect on the tax liabilities or tax attributes
of the Company or any of its subsidiaries.

       SECTION 6.04.  Other Actions.  Neither the Company nor any of its
subsidiaries, on the one hand, nor the Parent nor Sub or any of their
respective subsidiaries on the other hand, shall take any action that would
reasonably be expected to result in (i) any of the representations and
warranties of the Company on the one hand, or of Parent or Sub on the other
hand, set forth in this Agreement that are qualified as to materiality
becoming untrue, (ii) any of such representations and warranties that are not
so qualified becoming untrue in any material respect or (iii) any of the Offer
Conditions not being satisfied.

       SECTION 6.05.  Advice of Changes; Filings.  The Company shall confer
with Parent on a regular and frequent basis as reasonably requested by Parent
concerning operational matters and promptly advise Parent orally and, if
requested by Parent, in writing of any material adverse change with respect to
the Company.  The Company shall promptly provide to Parent (or its counsel)
copies of all filings made by the Company with any Governmental Entity in
connection with this Agreement and the transactions contemplated hereby.


                                  ARTICLE VII

                             Additional Agreements

       SECTION 7.01.  Company Stockholder Approval; Preparation of Proxy
Statement.  (a)  If the Company Stockholder Approval is required by law, the
Company will, as soon as practicable following the acceptance for payment of,
and payment for, Shares by Sub pursuant to and subject to the conditions of
the Offer (including the Stockholder Agreement Condition), duly call, give
notice of, convene and hold a meeting of its stockholders (the "Stockholders
Meeting") for the purpose of obtaining the Company Stockholder Approval.  The
Company will, through its Board of Directors, recommend to its stockholders
that the Company Stockholder Approval be given.  Notwithstanding the
foregoing, if Sub or any other subsidiary of Parent shall acquire at least 90%
of the outstanding Shares, the parties shall, at the request of Parent, take
all necessary and appropriate action to cause the Merger to become effective
as soon as practicable after the expiration of the Offer without a
stockholders meeting in accordance with Section 253 of the DGCL.

       (b)  If the Company Stockholder Approval is required by law, the
Company will, at Parent's request, as soon as practicable following the
expiration of the Offer, prepare and file a preliminary Proxy Statement
with the SEC and will use its best efforts to respond to any comments of
the SEC or its staff and to cause the Proxy Statement to be mailed to the
Company's stockholders as promptly as practicable after responding to all
such comments to the satisfaction of the staff.  The Company will notify
Parent promptly of the receipt of any comments from the SEC or its staff
and of any request by the SEC or its staff for amendments or supplements to
the Proxy Statement or for additional information and will supply Parent
with copies of all correspondence between the Company or any of its
representatives, on the one hand, and the SEC or its staff, on the other
hand, with respect to the Proxy Statement or the Merger.  If at any time
prior to the Stockholders Meeting there shall occur any event that should
be set forth in an amendment or supplement to the Proxy Statement, the
Company will promptly prepare and mail to its stockholders and file with
the SEC such an amendment or supplement.  The Company will not mail any
Proxy Statement, or any amendment or supplement thereto, to which Parent
reasonably objects; provided, that Parent shall identify its objections and
fully cooperate with the Company to create a mutually satisfactory Proxy
Statement.

       (c)  Parent agrees to cause all Shares purchased pursuant to the
Offer and all other Shares owned by Parent or any subsidiary of Parent to
be voted in favor of the Company Stockholder Approval.

       SECTION 7.02.  Access to Information; Confidentiality.  The Company
shall, and shall cause each of its subsidiaries to, afford to Parent, and to
Parent's officers, employees, accountants, counsel, financial advisers and
other representatives, reasonable access during normal business hours during
the period prior to the Effective Time to all their respective properties,
books, contracts, commitments, personnel and records and, during such period,
the Company shall furnish promptly to Parent (a) a copy of each report,
schedule, registration statement and other document filed by it during such
period pursuant to the requirements of Federal or state securities laws and
(b) all other information concerning its business, properties and personnel as
Parent may reasonably request.  Except as required by law, Parent will hold,
and will cause its officers, employees, accountants, counsel, financial
advisers and other representatives and affiliates to hold, any and all
information received from the Company or any of its subsidiaries, directly or
indirectly, in confidence, according to the terms of the confidentiality
agreement dated July 11, 1998, as amended, between the Company and Parent (the
"Confidentiality Agreement").

       SECTION 7.03.  Reasonable Efforts; Notification.  (a)  Upon the terms
and subject to the conditions set forth in this Agreement, each of the parties
agrees to use all reasonable efforts to take, or cause to be taken, all
actions, and to do, or cause to be done, and to assist and cooperate with the
other parties in doing, all things necessary, proper or advisable to
consummate and make effective, in the most expeditious manner practicable, the
Offer and the Merger, and the other transactions contemplated by this
Agreement and the Stockholder Agreement, including (i) the obtaining of all
necessary actions or nonactions, waivers, consents and approvals from
Governmental Entities and the making of all necessary registrations and
filings (including filings with Governmental Entities, if any) and the taking
of all reasonable steps as may be necessary to obtain an approval or waiver
from, or to avoid an action or proceeding by, any Governmental Entity, (ii)
the obtaining of all necessary consents, approvals or waivers from third
parties, (iii) the defending of any lawsuits or other legal proceedings,
whether judicial or administrative, challenging this Agreement or the
Stockholder Agreement or the consummation of any of the transactions
contemplated hereby or thereby, including seeking to have any stay or
temporary restraining order entered by any court or other Governmental Entity
vacated or reversed, and (iv) the execution and delivery of any additional
instruments necessary to consummate the transactions contemplated by, and to
fully carry out the purposes of, this Agreement.  In connection with and
without limiting the foregoing, the Company and its Board of Directors shall
(i) take all reasonable actions available to them to ensure that no state
takeover statute or similar statute or regulation is or becomes applicable to
the Offer, the Merger, this Agreement, the Stockholder Agreement or any of the
other transactions contemplated by this Agreement or the Stockholder Agreement
and (ii) if any state takeover statute or similar statute or regulation
becomes applicable to the Offer, the Merger, this Agreement, the Stockholder
Agreement or any other transaction contemplated by this Agreement or the
Stockholder Agreement, take all reasonable actions available to them to ensure
that the Offer, the Merger and the other transactions contemplated by this
Agreement and the Stockholder Agreement may be consummated as promptly as
practicable on the terms contemplated by this Agreement and the Stockholder
Agreement and otherwise to minimize the effect of such statute or regulation
on the Offer, the Merger, this Agreement, the Stockholder Agreement and the
other transactions contemplated by this Agreement or the Stockholder
Agreement.  Nothing in this Agreement shall be deemed to require Parent to
agree to dispose of any significant assets or businesses of the Company,
Parent or any of their respective subsidiaries.

       (b)  The Company shall give prompt notice to Parent of (i) any
representation or warranty made by it contained in this Agreement that is
qualified as to materiality becoming untrue or inaccurate in any respect or
any such representation or warranty that is not so qualified becoming untrue
or inaccurate in any material respect or (ii) the failure by it to comply with
or satisfy in any material respect any covenant, condition or agreement to be
complied with or satisfied by it under this Agreement; provided, however, that
no such notification shall affect the representations, warranties, covenants
or agreements of the parties or the conditions to the obligations of the
parties under this Agreement.

       SECTION 7.04.  Cooperation.  Without limiting the generality of Section
7.03, Parent, Sub and Company shall together, or pursuant to an allocation of
responsibility to be agreed between them, coordinate and cooperate (i) in
determining whether any action by or in respect of, or filing with, any
governmental body, agency or official, or authority is required and (ii) in
promptly seeking any such action or making any such filing, furnishing
information required in connection therewith and seeking timely to obtain any
such actions.

       SECTION 7.05.  Stock Option Plans.  (a)  As soon as practicable
following the date of this Agreement but in no event later than the
consummation of the Offer, the Company (or, if appropriate, the Board of
Directors of the Company or any committee administering the Stock Option Plans
(as defined below)) shall take actions such that (including by adopting
resolutions or taking any other actions) each outstanding option to purchase
Shares (a "Company Stock Option") heretofore granted under any stock option,
stock appreciation rights or stock purchase plan, program or arrangement of
the Company (collectively, the "Stock Option Plans") that is outstanding
immediately prior to the consummation of the Offer, whether or not then
exercisable, shall be canceled immediately prior to the Effective Time in
exchange for an amount in cash, payable at the time of such cancelation, equal
to the product of (y) the number of Shares subject to such Company Stock
Option immediately prior to the Effective Time and (z) the excess of the price
per Share to be paid in the Offer over the per Share exercise price of such
Company Stock Option.  The Company (or, if appropriate, the Board of Directors
of the Company or any committee administering the Stock Option Plans) shall
take actions such that immediately prior to the Effective Time the Company
Stock Options set forth on Schedule 7.05(a) to the Company Disclosure Schedule
are canceled as set forth above.  The Company shall not make, or agree to
make, any payment of any kind to any holder of a Company Stock Option (except
for the payment described above) without the consent of Parent.

       (b)  Notwithstanding Section 7.05(a), in the case of the Company's
Savings-Related Share Option Scheme (the "Scheme") under the Company's
Employee Stock Option/Purchase Plan, the provisions of Section 7.05(a) shall
not apply and, in lieu thereof, (i) the Board of Directors of the Company
shall take action under Section 12.3(b) of the Company's Employee Stock
Option/Purchase Plan to provide that, in the case of outstanding options under
the Scheme, participants shall, upon any exercise of an option in accordance
with the Scheme (or at any earlier time as may be permitted) and the payment
of the applicable exercise price, be entitled to receive only a cash payment
for each share of Company Common Stock reserved for purposes of the Scheme to
which such participant would otherwise be entitled upon such exercise equal to
the price per Share to be paid in the Offer and (ii) as soon as practicable
following the date of this Agreement but in no event later than the
consummation of the Offer, the Company shall use its best efforts to obtain the
approval of each participant holding an option under the Scheme to the
surrender and cancellation thereof in consideration of a cash payment to be
made by the Company in such amount or in accordance with such formula as shall
have been reviewed and consented to by Parent prior to the seeking of any such
approval by the Company.  In addition, and only to the extent permitted by
applicable law, the Company shall take action to cease employee contributions
to the Scheme no later than the consummation of the Offer.  The Company and
the Parent agree to take such other actions as shall reasonably be required to
accomplish the surrender and cancellation of the options under the Scheme as
contemplated by the foregoing.

       (c)  Subject to Section 7.05(a) and Section 7.05(b), all Stock Option
Plans shall terminate as of the Effective Time and the provisions in any other
Benefit Plan providing for the issuance, transfer or grant of any capital
stock of the Company or any interest in respect of any capital stock of the
Company shall be deleted as of the Effective Time.  The Company shall ensure
that following the consummation of the Offer no holder of a Company Stock
Option or any participant in any Stock Option Plan shall have any right
thereunder to acquire any capital stock of the Company, Parent or the
Surviving Corporation, and the Company shall use its reasonable best efforts
to ensure that following the Effective Time, no holder of a Company Stock
Option set forth on Schedule 7.05(a) to the Company Disclosure Schedule or any
participant in any Stock Option Plan shall have any right thereunder to
acquire any capital stock of the Company, Parent or the Surviving Corporation.

       SECTION 7.06.  Indemnification, Exculpation and Insurance.  (a)  Parent
agrees that all rights to indemnification and exculpation (including the
advancement of expenses) from liabilities for acts or omissions occurring at
or prior to the Effective Time (including with respect to the transactions
contemplated by this Agreement) existing now or at the Effective Time in favor
of the current or former directors or officers of the Company as provided in
its Certificate of Incorporation, its Bylaws (each as in effect on the date
hereof) and indemnification agreements shall be assumed by the Surviving
Corporation in the Merger, without further action, as of the Effective Time
and shall survive the Merger and shall continue in full force and effect
without amendment, modification or repeal in accordance with their terms for a
period of not less than six years after the Effective Time; provided, however,
that if any claims are asserted or made within such six year period, all
rights to indemnification (and to advancement of expenses) hereunder in
respect of any such claims shall continue, without diminution, until
disposition of any and all such claims.

       (b)  In the event that Parent, the Surviving Corporation or any of
their successors or assigns (i) consolidates with or merges into any other
person and is not the continuing or surviving corporation or entity of such
consolidation or merger or (ii) transfers or conveys all or substantially all
of its properties and assets to any person, then, and in each such case,
proper provision will be made so that the successors and assigns of Parent or
the Surviving Corporation, as the case may be, shall expressly assume the
obligations set forth in this Section 7.06.  In the event the Surviving
Corporation transfers any material portion of its assets, in a single
transaction or in a series of transactions, Parent will either guarantee the
indemnification obligations referred to in Section 7.06(a) or take such other
action to insure that the ability of the Surviving Corporation, legal and
financial, to satisfy such indemnification obligations will not be diminished
in any material respect.

       (c)  For six years after the Effective Time, Parent shall, unless
Parent agrees in writing to guarantee the indemnification obligations set
forth in Section 7.06(a), provide officers' and directors' liability insurance
in respect of acts or omissions occurring at or prior to the Effective Time,
covering each person currently covered by the Company's officers' and
directors' liability insurance policy, or who becomes covered by such policy
prior to the Effective Time, on terms with respect to coverage and amount no
less favorable than those of such policy in effect on the date hereof;
provided that in satisfying its obligation under this Section 7.06(c) Parent
shall not be obligated to pay premiums in excess of 200% of the amount per
annum paid by the Company in its last full fiscal year; and provided further
that Parent shall nevertheless be obligated to provide such coverage as may be
obtained for such 200% amount.  The Company represents that it paid officers'
and directors' liability insurance premiums as set forth in Schedule 7.06(c).

       (d)  The provisions of this Section 7.06 (i) are intended to be for the
benefit of, and will be enforceable by, each indemnified party, his or her
heirs and his or her representatives and (ii) are in addition to, and not in
substitution for, any other rights to indemnification or contribution that any
such person may have by contract or otherwise.

       SECTION 7.07.  Directors.  Promptly upon the acceptance for payment of,
and payment for, any Shares by Sub pursuant to and subject to the conditions
(including the Stockholder Agreement Condition) of the Offer, Sub shall be
entitled to designate such number of directors on the Board of Directors of
the Company as will give Sub, subject to compliance with Section 14(f) of the
Exchange Act, a majority of such directors, and the Company shall, at such
time, cause Sub's designees to be so elected by its existing Board of
Directors; provided, however, that in the event that Sub's designees are
elected to the Board of Directors of the Company, until the Effective Time
such Board of Directors shall have at least two directors who are directors of
the Company on the date of this Agreement and who are not officers of the
Company or any of its subsidiaries (the "Independent Directors") and; provided
further that, in such event, if the number of Independent Directors shall be
reduced below two for any reason whatsoever, the remaining Independent
Director shall designate a person to fill such vacancy who shall be deemed to
be an Independent Director for purposes of this Agreement or, if no
Independent Directors then remain, the other directors of the Company on the
date hereof shall designate two persons to fill such vacancies who shall not
be officers or affiliates of the Company or any of its subsidiaries, or
officers or affiliates of Parent or any of its subsidiaries, and such persons
shall be deemed to be Independent Directors for purposes of this Agreement.
Subject to applicable law, the Company shall take all action requested by
Parent necessary to effect any such election, including mailing to its
stockholders the Information Statement containing the information required by
Section 14(f) of the Exchange Act and Rule 14f-1 promulgated thereunder, and
the Company agrees to make such mailing with the mailing of the Schedule 14D-9
(provided that Sub shall have provided to the Company on a timely basis in
writing all information required to be included in the Information Statement
with respect to Sub's designees).  In connection with the foregoing, the
Company will promptly, at the option of Parent, either increase the size of
the Company's Board of Directors or use its best efforts to obtain the
resignation of such number of its current directors as is necessary to enable
Sub's designees to be elected or appointed to, and to constitute a majority
of, the Company's Board of Directors as provided above.

       SECTION 7.08.  Fees and Expenses.  All fees and expenses incurred in
connection with the Offer, the Merger, this Agreement and the Stockholder
Agreement and the transactions contemplated by this Agreement and the
Stockholder Agreement shall be paid by the party incurring such fees or
expenses, whether or not the Offer or the Merger is consummated.

       SECTION 7.09.  Transfer Taxes.  All state, local or foreign sales, use,
real property transfer, stock transfer or similar taxes (including any
interest or penalties with respect thereto) attributable to the Merger shall
be timely paid by the Company.

       SECTION 7.10.  Public Announcements.  Parent and Sub, on the one hand,
and the Company, on the other hand, will consult with each other before
issuing, and provide each other with a reasonable opportunity to review and
comment upon, any press release or other public statements with respect to the
transactions contemplated by this Agreement and the Stockholder Agreement,
including the Offer and the Merger, and shall not issue, or permit any of their
respective subsidiaries to issue, any such press release or make any such
public statement prior to such consultation, except as may be required by
applicable law, court process or by obligations pursuant to any listing
agreement with any national securities exchange or national securities
quotation system, in which case the party making such release will use
reasonable efforts to obtain comments from the other party before issuance of
such release or statement.  The parties agree that the initial press release
to be issued with respect to the transactions contemplated by this Agreement
shall be in the form heretofore agreed to by the parties.

       SECTION 7.11.  Severance Agreements.  Parent acknowledges and agrees
that (1) the letter agreements dated May 1, 1996 in effect between the Company
and Steven L. Artusi, G. Taylor Seward and Thomas J. Oberhausen, respectively
(collectively, the "Severance Agreements"), are, and following consummation of
the transactions contemplated by this Agreement will continue to be, valid,
in full force and effect and enforceable in accordance with their respective
terms by the parties thereto; (2) Parent shall honor the Severance Agreements
in accordance with their terms; (3) each of the three individuals subject to a
Severance Agreement shall be entitled, on any date within sixty days following
the Effective Time, to declare that he has been "constructively terminated"
(by virtue of the Offer and the Merger resulting in an involuntary material
change in such person's duties) and to discontinue his duties with the
Company, whereupon the "Company's Notice Period" (as such term is defined in
each of the Severance Agreements) shall be deemed to have commenced; provided
that if such person continues his employment with the Company (or its
successor) for more than sixty days following the Effective Time, any right
arising solely by virtue of (3) above shall terminate.

       SECTION 7.12.  Continuation of Benefits.  It is Parent's intention
that, for a period of not less than one year after the Effective Time,
employees of the Company who continue their employment after the Effective
Time will be provided compensation and employee benefits which are
substantially comparable in the aggregate to those provided for such employees
as of the date hereof.  Neither the Parent nor the Surviving Corporation will
have any obligation to issue, or adopt any plans or arrangements providing for
the issuance of, shares of capital stock, warrants, options, stock
appreciation rights or other rights in respect of any shares of capital stock
of any entity or any securities convertible or exchangeable into such shares
pursuant to any such plans or arrangements.  Any plans or arrangements of the
Company providing for such issuance shall be disregarded in determining
whether employee benefits are substantially comparable in the aggregate.

       SECTION 7.13.  Stop Transfer.  The Company shall not register the
transfer of any certificate representing any Subject Shares (as defined in the
Stockholder Agreement), unless such transfer is made to Parent or Sub or
otherwise in compliance with the Stockholder Agreement.  The Company will
inscribe upon any certificates representing Subject Shares tendered by a
Stockholder (as defined in the Stockholder Agreement) for such purpose the
following legend:  "The shares of Common Stock, $.01 par value, of DePuy, Inc.
represented by this certificate are subject to a Stockholder Agreement dated
as of July 21, 1998, and may not be sold or otherwise transferred, except in
accordance therewith.  Copies of such Agreement may be obtained at the
principal executive offices of DePuy, Inc."

       SECTION 7.14.  Purchase of Foreign Subsidiaries.  Parent and its
affiliates shall have the right, at the option of Parent, to purchase
immediately prior to the consummation of the Offer any subsidiary of the
Company that is not incorporated or organized under the laws of a jurisdiction
within the United States at a price and on such terms as may be determined by
mutual agreement of the Parent and the Company; provided that all of the
conditions set forth in Exhibit A have been satisfied or waived and Parent and
Sub are unconditionally obligated to consummate the Offer.  If the Parent and
the Company are unable to agree upon a price or terms for such sale, Parent
and the Company shall elect an independent appraisal firm to determine such
price or terms.  The conclusions of such appraisal firm shall be conclusive
and binding.  The fees of such appraisal firm shall be shared equally by
Parent and the Company.  Parent agrees that in no event will the Company be
deemed to have breached any of its representations, warranties, covenants or
other obligations under this Agreement (including Section 4.15) by reason of
(whether directly or indirectly, whether in whole or in part) any taxes or
liabilities incurred, any payments made, or any action taken or any omissions
of any necessary action as a result of or in connection with (i) Parent's
exercise of its right to purchase the Company's foreign subsidiaries prior to
the consummation of the Offer pursuant to this Section 7.14 or (ii) any other
transaction or agreement contemplated by this Section 7.14 or entered into in
connection therewith.


                                 ARTICLE VIII

                                  Conditions

       SECTION 8.01.  Conditions to Each Party's Obligation To Effect the
Merger.  The respective obligation of each party to effect the Merger shall be
subject to the satisfaction or waiver prior to the Closing Date of the
following conditions:

      (a)   Company Stockholder Approval.  If required by applicable law, the
     Company Stockholder Approval shall have been obtained; provided that
     Parent and Sub shall vote all their Shares in favor of the Merger.

      (b)   No Injunctions or Restraints.  No statute, rule, decision,
     regulation, executive order, decree, temporary restraining order,
     preliminary or permanent injunction or other order issued by any court
     of competent jurisdiction or other Governmental Entity or other legal
     restraint or prohibition preventing the consummation of the Merger
     shall be in effect; provided, however, that the party seeking to
     invoke such condition shall have performed its obligations under
     Sections 7.03 and 7.04.

      (c)  Purchase of Shares.  Sub shall have previously accepted for
     payment and paid for Shares pursuant to and subject to the conditions
     (including the Stockholder Agreement Condition) of the Offer and, if
     any Subject Shares were not purchased pursuant to the Offer, pursuant
     to the Stockholder Agreement.


                                  ARTICLE IX

                           Termination and Amendment

       SECTION 9.01.  Termination.  This Agreement may be terminated at any
time prior to the Effective Time, whether before or after approval of the
terms of this Agreement by the stockholders of the Company:

      (a)  by mutual written consent of Parent and the Company;

      (b)  by either Parent or the Company:

                      (i) if Sub shall not have accepted for payment Shares
                  pursuant to the Offer prior to March 31, 1999; provided,
                  however, that the right to terminate this Agreement pursuant
                  to this Section 9.01(b)(i) shall not be available to any party
                  whose failure to perform any of its obligations under this
                  Agreement results in the failure of any Offer Condition or if
                  the failure of such condition results from facts or
                  circumstances that constitute a willful and intentional
                  material breach of representation or warranty under this
                  Agreement by such party; or

                      (ii) if any Governmental Entity shall have issued an
                  order, decree or ruling or taken any other action
                  permanently enjoining, restraining or otherwise
                  prohibiting the acceptance for payment of, or payment
                  for, Shares pursuant to the Offer or the Merger and such
                  order, decree or ruling or other action shall have become
                  final and nonappealable; provided, however, that the
                  Party seeking to terminate this Agreement pursuant to the
                  provision shall have performed its obligations under
                  Section 7.03 and 7.04.

          (c)  by Parent or Sub prior to Sub's obligation to accept Shares
      for payment pursuant to the Offer in the event of a breach by the
      Company of any representation, warranty, covenant or other agreement
      contained in this Agreement which (i) would give rise to the failure
      of a condition set forth in paragraph (d) or (e) of Exhibit A and
      (ii) cannot be or has not been cured within 20 days after the giving
      of written notice to the Company; or

          (d)  by the Company, if Sub or Parent shall have (A) failed to
      commence the Offer within five business days of the public
      announcement (on the date hereof or the following day) by Parent and
      the Company of this Agreement, (B) failed to pay for Shares pursuant
      to the Offer in accordance with Section 1.01(a) hereof or (C)
      breached in any material respect any of their respective
      representations, warranties, covenants or other agreements contained
      in this Agreement, which breach or failure to perform in respect of
      clause (C) is incapable of being cured or has not been cured within
      20 days after the giving of written notice to Parent or Sub, as
      applicable, except, in any case under clause (C), such breaches and
      failures which individually or in the aggregate are not reasonably
      likely to affect adversely Parent's or Sub's ability to complete the
      Offer or the Merger subject to the terms and conditions of this
      Agreement.

       SECTION 9.02.  Effect of Termination.  In the event of a termination of
this Agreement by either the Company or Parent as provided in Section 9.01,
this Agreement shall forthwith become void and there shall be no liability or
obligation on the part of Parent, Sub or the Company or their respective
officers or directors, except with respect to the last sentence of Section
1.02(c), Section 5.06, the last sentence of Section 7.02, Section 7.08, this
Section 9.02 and Article X; provided, however, that nothing herein shall
relieve any party for liability for any willful and intentional breach hereof.

       SECTION 9.03.  Amendment.  This Agreement may be amended by the parties
hereto, by action taken or authorized by their respective Boards of Directors,
at any time before or after obtaining the Company Stockholder Approval (if
required by law), but, after any such approval, no amendment shall be made
which by law requires further approval by such shareholders without obtaining
such further approval.  This Agreement may not be amended except by an
instrument in writing signed on behalf of each of the parties hereto.

       SECTION 9.04.  Extension; Waiver.  At any time prior to the Effective
Time, the parties hereto, by action taken or authorized by their respective
Boards of Directors, may, to the extent legally allowed, (i) extend the time
for the performance of any of the obligations or other acts of the other
parties hereto, (ii) waive any inaccuracies in the representations and
warranties contained herein or in any document delivered pursuant hereto or
(iii) subject to Section 9.03, waive compliance with any of the agreements or
conditions contained herein.  Any agreement on the part of a party hereto to
any such extension or waiver shall be valid only if set forth in a written
instrument signed on behalf of such party.  The failure of any party to this
Agreement to assert any of its rights under this Agreement or otherwise shall
not constitute a waiver of those rights.

       SECTION 9.05.  Procedure for Termination, Amendment, Extension or
Waiver.  A termination of this Agreement pursuant to Section 9.01, an
amendment of this Agreement pursuant to Section 9.03 or an extension or waiver
pursuant to Section 9.04 shall, in order to be effective, require in the case
of Parent, Sub or the Company, action by its Board of Directors or the duly
authorized designee of its Board of Directors; provided, however, that in the
event that Sub's designees are appointed or elected to the Board of Directors
of the Company as provided in Section 7.07, after the acceptance for payment
and payment of Shares pursuant to and subject to the Conditions (including the
Stockholder Agreement Condition) of the Offer and prior to the Effective Time,
the affirmative vote of a majority of the directors of the Company that were
not designated by Parent or Sub shall be required by the Company to (i) amend
or terminate this Agreement by the Company, (ii) exercise or waive any of the
Company's rights or remedies under this Agreement, (iii) extend the time for
performance of Parent's and Sub's respective obligations under this Agreement
or (iv) take any action to amend or otherwise modify the Company's Certificate
of Incorporation or Bylaws.


                                   ARTICLE X

                                 Miscellaneous

       SECTION 10.01.  Nonsurvival of Representations, Warranties and
Agreements.  Except as otherwise provided in this Section 10.01, none of the
representations, warranties or covenants in this Agreement or in any instrument
delivered pursuant to this Agreement shall survive the Effective Time or, in
the case of the Company, shall survive the acceptance for payment of, and
payment for, any Shares by Sub pursuant to the Offer.  This Section 10.01
shall not limit any covenant or agreement of the parties which by its terms
contemplates performance after the Effective Time.

       SECTION 10.02.  Notices.  All notices and other communications
hereunder shall be in writing and shall be deemed given if delivered
personally, telecopied (which is confirmed), sent by overnight courier
(providing proof of delivery) or mailed by registered or certified mail (return
receipt requested) to the parties at the following addresses or telecopier
numbers (or at such other address or telecopier number for a party as shall be
specified by like notice):

       (a) if to Parent or Sub, to

           Johnson & Johnson
           One Johnson & Johnson Plaza
           New Brunswick, NJ 08933

           Attention:  General Counsel

           Telecopy No.:  (732) 524-2788

           with a copy to:

           Cravath, Swaine & Moore
           Worldwide Plaza
           825 Eighth Avenue
           New York, NY 10019

           Attention:  Robert A. Kindler, Esq.

           Telecopy No.:  (212) 474-3700

           and

       (b) if to the Company, to

           DePuy, Inc.
           700 Orthopaedic Drive
           Warsaw, Indiana 46581-0988

           Attention:  President

           Telecopy No.:  (219) 269-5675

           with a copy to:

           Coudert Brothers
           1114 Avenue of the Americas
           New York, NY 10036-7703

           Attention:  Jeffrey E. Cohen, Esq.

           Telecopy No.:  (212) 626-4120


       SECTION 10.03.  Interpretation.  When a reference is made in this
Agreement to an Article or a Section, such reference shall be to an Article or
a Section of this Agreement unless otherwise indicated.  The table of contents
and headings contained in this Agreement are for reference purposes only and
shall not affect in any way the meaning or interpretation of this Agreement.
Whenever the words "include", "includes" or "including" are used in this
Agreement, including Exhibit A, they shall be deemed to be followed by the
words "without limitation".  As used in this Agreement, including Exhibit A,
the term "subsidiary" of any person means another person whether foreign or
domestic, an amount of the voting securities, other voting ownership or voting
partnership interests of which is sufficient to elect at least a majority of
its Board of Directors or other governing body (or, if there are no such
voting interests, 50% or more of the equity interests of which) is owned
directly or indirectly by such first person.  As used in this Agreement,
including Exhibit A, the term "affiliate" of any person means any person,
whether foreign or domestic, that directly or indirectly, through one or more
intermediaries, controls, is controlled by, or is under common control with,
such first person.  As used in this Agreement, including Exhibit A, the term
"key employee" means an employee of the Company or any of its subsidiaries
with annual cash compensation in excess of $300,000.  As used in this
Agreement, including Exhibit A, "material adverse effect" means, when used in
connection with the Company, any effect that is materially adverse to the
business, financial condition or results of operations of the Company and its
subsidiaries, taken as a whole, or would prevent or materially delay the
consummation of the Offer or the Merger.  As used in this Agreement, including
Exhibit A, "material adverse change" means any change that is reasonably
likely to have a material adverse effect.

       SECTION 10.04.  Counterparts.  This Agreement may be executed in two or
more counterparts, all of which shall be considered one and the same agreement
and shall become effective when two or more counterparts have been signed by
each of the parties and delivered to the other parties, it being understood
that all parties need not sign the same counterpart.

       SECTION 10.05.  Entire Agreement; Third Party Beneficiaries.  This
Agreement and the Confidentiality Agreement (including the documents and the
instruments referred to herein) (a) constitute the entire agreement and
supersede all prior agreements and understandings, both written and oral,
among the parties with respect to the subject matter hereof, and (b) except as
provided in Section 7.06 and Section 7.11, Articles II and III are not
intended to confer upon any person other than the parties hereto any rights or
remedies hereunder.

       SECTION 10.06.  Governing Law.  This Agreement shall be governed by,
and construed in accordance with, the laws of the State of Delaware regardless
of the laws that might otherwise govern under applicable principles of
conflicts of law thereof.

       SECTION 10.07.  Assignment.  Neither this Agreement nor any of the
rights, interests or obligations hereunder shall be assigned by any of the
parties hereto (whether by operation of law or otherwise) without the prior
written consent of the other parties, except that Sub may assign, in its sole
discretion, any or all of its rights, interests and obligations hereunder to
Parent or to any direct or indirect wholly-owned subsidiary of Parent.
Subject to the preceding sentence, this Agreement will be binding upon, inure
to the benefit of and be enforceable by the parties and their respective
successors and assigns.

       SECTION 10.08.  Enforcement.  The parties agree that irreparable damage
would occur in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached.
It is accordingly agreed that the parties shall be entitled to an injunction
or injunctions to prevent breaches of this Agreement and to enforce
specifically the terms and provisions of this Agreement in any court of the
United States located in the State of Delaware or in a Delaware state court,
this being in addition to any other remedy to which they are entitled at law
or in equity.  In addition, each of the parties hereto (i) consents to submit
such party to the personal jurisdiction of any Federal court located in the
State of Delaware or any Delaware state court in the event any dispute arises
out of this Agreement or any of the transactions contemplated hereby, (ii)
agrees that such party will not attempt to deny or defeat such personal
jurisdiction by motion or other request for leave from any such court, (iii)
agrees that such party will not bring any action relating to this Agreement or
any of the transactions contemplated hereby in any court other than a Federal
court sitting in the State of Delaware or a Delaware state court and (iv)
waives any right to trial by jury with respect to any claim or proceeding
related to or arising out of this Agreement or any of the transactions
contemplated hereby.

       SECTION 10.09.  Severability.  If any term or other provision of this
Agreement is invalid, illegal or incapable of being enforced by any rule of
law or public policy, all other conditions and provisions of this Agreement
shall nevertheless remain in full force and effect.  Upon such determination
that any term or other provision is invalid, illegal or incapable of being
enforced, the parties hereto shall negotiate in good faith to modify this
Agreement so as to effect the original intent of the parties as closely as
possible to the fullest extent permitted by applicable law in an acceptable
manner to the end that the transactions contemplated hereby are fulfilled to
the extent possible.

       SECTION 10.10.  Compliance with Law.  Nothing in this Agreement,
including Section 1.02 or 6.02, shall in any way prevent the Company or the
Board of Directors of the Company from making any disclosure to the
stockholders of the Company, or taking any position, that is required by
Federal or state law.  Nothing in this Agreement, including Section 6.01,
shall require the Company or any of its subsidiaries to take any action
prohibited by, or refrain from taking any action required by, applicable Merger
Control Laws.

       IN WITNESS WHEREOF, Parent, Sub and the Company have caused this
Agreement to be signed by their respective officers thereunto duly authorized
as of the date first written above.


                                          JOHNSON & JOHNSON,

                                          by /s/ James R. Utaski
                                             ----------------------
                                             Name:  James R. Utaski
                                             Title: Vice President



                                          LIB ACQUISITION CORP.,

                                          by /s/ James R. Hilton
                                             ----------------------
                                             Name:  James R. Hilton
                                             Title: Vice President


                                          DEPUY, INC.,

                                          by /s/ James A. Lent
                                             ----------------------
                                             Name:  James A. Lent
                                             Title: Chairman and Chief
                                                    Executive Officer


                                                                     EXHIBIT A

                            Conditions of the Offer
                            -----------------------

       Notwithstanding any other term of the Offer, Sub shall not be required
to accept for payment or, subject to any applicable rules and regulations of
the SEC, including Rule 14e-1(c) under the Exchange Act (relating to Sub's
obligation to pay for or return tendered Shares after the termination or
withdrawal of the Offer), to pay for any Shares tendered pursuant to the Offer
unless (i) the Stockholder Agreement is valid, binding and in full force and
effect and enforceable by Parent and Sub in accordance with its terms and no
party thereto (other than Parent or Sub) is in material breach thereof, and
the Shares subject to the Stockholder Agreement shall have been either tendered
into the Offer or delivered to Sub for purchase immediately following the
Offer (the "Stockholder Agreement Condition"), (ii) any waiting period under
the HSR Act applicable to the purchase of Shares pursuant to the Offer shall
have expired or been terminated and (iii) Parent, Sub and Company shall have
received in respect of the Merger and any matters arising therefrom
confirmation by way of a decision from the Commission of the European Union
under Regulation 4064.89 (with or without the initiation of proceedings under
Article 6(1)(c) thereof) that the Merger and any matters arising therefrom are
compatible with the common market.  Furthermore, notwithstanding any other
term of the Offer, Sub shall not be required to accept for payment or, subject
as aforesaid, to pay for any Shares not theretofore accepted for payment or
paid for, and may terminate the Offer if, at any time on or after the date of
this Agreement and before the acceptance of such Shares for payment or the
payment therefor, any of the following conditions exists:

                (a) there shall be instituted or pending by any Governmental
            Entity any suit, action or proceeding (or by any other person any
            suit, action or proceeding that has a reasonable likelihood of
            success) (i) challenging the acquisition by Parent or Sub of any
            Shares under the Offer or pursuant to the Stockholder Agreement,
            seeking to restrain or prohibit the making or consummation of the
            Offer or the Merger or the performance of any of the other
            transactions contemplated by this Agreement or the Stockholder
            Agreement, or seeking to obtain from the Company, Parent or Sub any
            damages in connection with the aforesaid transactions that are
            material in relation to the Company and its subsidiaries taken as a
            whole, (ii) seeking to prohibit or materially limit the ownership or
            operation by the Company, Parent or any of their respective
            subsidiaries of a material portion of the business or assets of the
            Company and its subsidiaries, or Parent and its subsidiaries, in
            each case taken as a whole, or to compel the Company or Parent to
            dispose of or hold separate any material portion of the business or
            assets of the Company and its subsidiaries, or Parent and its
            subsidiaries, in each case taken as a whole, as a result of the
            Offer or any of the other transactions contemplated by this
            Agreement or the Stockholder Agreement, (iii) seeking to impose
            material limitations on the ability of Parent or Sub to acquire or
            hold, or exercise full rights of ownership of, any Shares to be
            accepted for payment pursuant to the Offer or purchased under the
            Stockholder Agreement including, without limitation, the right to
            vote such Shares on all matters properly presented to the
            stockholders of the Company or (iv) seeking to prohibit Parent or
            any of its subsidiaries from effectively controlling in any material
            respect any significant portion of the business or operations of the
            Company and its subsidiaries taken as a whole;

                (b) there shall be any statute, rule, regulation, judgment,
            order or injunction enacted, entered, enforced, promulgated or
            deemed applicable to the Offer or the Merger, or any other action
            shall be taken by any Governmental Entity or court, other than the
            application to the Offer or the Merger of the applicable waiting
            period under the Merger Control Laws, that is reasonably likely to
            result, directly or indirectly, in any of the consequences referred
            to in clauses (i) through (iv) of paragraph (a) above;

                (c) there shall have occurred any material adverse change with
            respect to the Company;

                (d) any of the representations and warranties of the Company set
            forth in this Agreement that are qualified as to materiality shall
            not be true and correct or any such representations and warranties
            that are not so qualified shall not be true and correct in any
            material respect, in each case at the date of this Agreement and at
            the scheduled or extended expiration of the Offer;

                (e) the Company shall have failed to perform in any material
            respect any material obligation or to comply in any material respect
            with any material agreement or material covenant of the Company to
            be performed or complied with by it under this Agreement; or

                (f) this Agreement shall have been terminated in accordance with
            its terms;

which, in the reasonable judgment of Parent or Sub in any such case, and
regardless of the circumstances (including any action or omission by Parent or
Sub) giving rise to any such condition, makes it inadvisable to proceed with
such acceptance for payment or payments therefor.

       The foregoing conditions in paragraphs (a) through (f) are for the sole
benefit of Sub and Parent and may, subject to the terms of this Agreement, be
waived by Sub and Parent in whole or in part at any time and from time to time
in their sole discretion.  The failure by Parent or Sub at any time to
exercise any of the foregoing rights shall not be deemed a waiver of any such
right, the waiver of any such right with respect to particular facts and
circumstances shall not be deemed a waiver with respect to any other facts and
circumstances and each such right shall be deemed an ongoing right that may be
asserted at any time and from time to time.  Terms used herein but not defined
herein shall have the meanings assigned to such terms in the Agreement of
which this Exhibit A is a part.

                                                          EXHIBIT 99.3
                                                          CONFORMED COPY

                        STOCKHOLDER AGREEMENT dated as of July 21, 1998,
                    among JOHNSON & JOHNSON, a New Jersey corporation
                    ("Parent"), LIB ACQUISITION CORP., a Delaware
                    corporation and a wholly owned subsidiary of Parent
                    ("Sub") and the parties listed on Schedule A attached
                    hereto (the "Stockholders").

                  WHEREAS Parent, Sub and DePuy, Inc., a Delaware corporation
(the "Company"), propose to enter into an Agreement and Plan of Merger dated as
of the date hereof (as the same may be amended or supplemented in accordance
with this Agreement, the "Merger Agreement") providing for (i) the making of a
cash tender offer (as such offer may be amended from time to time as permitted
under the Merger Agreement, the "Offer") by Sub for all the outstanding shares
of common stock, par value $.01 per share, of the Company ("Company Common
Stock") and (ii) for the merger of Sub with and into the Company (the "Merger"),
upon the terms and subject to the conditions set forth in the Merger Agreement;

                  WHEREAS each Stockholder is the record and beneficial owner of
the number of shares of Company Common Stock set forth opposite such
Stockholder's name on Schedule A attached hereto (such shares of Company Common
Stock, together with any other shares of capital stock of the Company acquired
by the Stockholders after the date hereof and during the term of this Agreement
(including through the exercise of any stock options, warrants or similar
instruments), being collectively referred to herein as the "Subject Shares");
and

                  WHEREAS, as a condition to their willingness to enter into the
Merger Agreement, Parent and Sub have requested that the Stockholders enter into
this Agreement.

                  NOW, THEREFORE, to induce Parent and Sub to enter into, and in
consideration of their entering into, the Merger Agreement, and in consideration
of the premises and the representations, warranties and agreements contained
herein, the parties agree as follows:

                  1.  Purchase and Sale of Shares.  (a)  The Stockholders
hereby jointly and severally agree to sell to Sub, and Sub hereby agrees to
purchase, all Subject Shares of such Stockholders at a price equal to the
Offer Price; provided that such obligation to sell and such obligation to
purchase are subject to Sub having accepted shares of Company Common Stock
for payment under the Offer in accordance with Section 1.01 of the Merger
Agreement.  Each Stockholder may tender its Subject Shares into the Offer
and Sub may direct that each Stockholder tender its Subject Shares.  Any
Subject Shares not purchased in the Offer will be purchased by Sub
immediately following the purchase of shares of Company Common Stock in the
Offer.  Sub shall be entitled to deduct and withhold from the consideration
otherwise payable pursuant to this Agreement such amounts as may be
required to be deducted and withheld with respect to the making of such
payment under the Internal Revenue Code of 1986, as amended, or under any
provision of state, local or foreign tax law; provided, however, that Sub
shall promptly pay any amounts deducted and withheld hereunder to the
applicable governmental authority, shall promptly file all tax returns and
reports required to be filed in respect of such deductions and withholding,
and shall promptly provide to the Stockholders proof of such payment and a
copy of all such tax returns and reports.

                  (b) The Stockholders shall not be required to tender their
Subject Shares in the event of any amendment to the Merger Agreement that
creates any additional Offer Condition, reduces the Offer Price or otherwise
adversely affects the Stockholders without the prior written approval of the
Stockholders.

                  2.  Representations and Warranties of the Stockholders.
The Stockholders hereby jointly and severally represent and warrant to
Parent and Sub as follows:

                    (a) Authority. Each Stockholder has all requisite corporate
         power and authority to execute and deliver this Agreement and to
         consummate the transactions contemplated hereby. The execution,
         delivery and performance of this Agreement by each Stockholder, and the
         consummation of the transactions contemplated hereby, have been duly
         authorized by all necessary corporate action on the part of each
         Stockholder. This Agreement has been duly executed and delivered by
         each Stockholder and constitutes a valid and binding obligation of each
         Stockholder enforceable against each such Stockholder in accordance
         with its terms. Except for the expiration or termination of the
         applicable waiting periods under the Merger Control Laws (as defined
         below) and required filings with the Securities and Exchange
         Commission, the execution and delivery of this Agreement do not, and
         the consummation by Stockholders of the transactions contemplated
         hereby and compliance with the terms hereof will not, (i) conflict
         with, or result in any violation of, or default (with or without notice
         or lapse of time or both) under any provision of, any trust agreement,
         loan or credit agreement, note, bond, mortgage, indenture, lease or
         other agreement, instrument, permit, concession, franchise, license,
         judgment, order, notice, decree, statute, law, ordinance, rule or
         regulation applicable to any Stockholder or to the property or assets
         of any Stockholder, (ii) require any filing with, or permit,
         authorization, consent or approval of, any Federal, state or local
         government or any court, tribunal, administrative agency or commission
         or other governmental or regulatory authority or agency, domestic,
         foreign or supranational, or (iii) violate any order, writ, injunction,
         decree, statute, rule or regulation applicable to any Stockholder or
         any of the properties or assets of any Stockholder, including the
         Subject Shares. "Merger Control Laws" means (i) the Hart-Scott-Rodino
         Antitrust Improvements Act of 1976, as amended (the "HSR Act"), and
         (ii) Council Regulation (EEC) No. 4064/89 of 21 December 1989 and (iii)
         all amendments of, and all other applicable bills, acts, decrees,
         regulations or ordinances relating to, the foregoing legislative acts.

                    (b) Capitalization. At the close of business on July 20,
         1998, the Stockholders were the record and beneficial owners of
         83,000,000 Shares.

                    (c) The Subject Shares.  Each Stockholder is the
         record and beneficial owner of, and has good and valid title to,
         the Subject Shares set forth opposite its name on Schedule A
         attached hereto, free and clear of any claims, liens,
         encumbrances, security interests, options, charges and
         restrictions of any kind (other than restrictions pursuant to
         applicable securities laws).  Each Stockholder does not own, of
         record or beneficially, any shares of capital stock of the Company
         other than the Subject Shares set forth opposite its name on
         Schedule A attached hereto.  Each Stockholder has the sole right
         to vote such Subject Shares, and none of such Subject Shares are
         subject to any voting trust or other agreement, arrangement or
         restriction with respect to the voting of such Subject Shares,
         except as contemplated by this Agreement.

                    (d) Brokers. No broker, investment banker, financial advisor
         or other person is entitled to any broker's, finder's, financial
         advisor's or other similar fee or commission in connection with the
         transactions contemplated by this Agreement based upon arrangements
         made by or on behalf of the Stockholders.

                 3.  Representation and Warranty of Parent and Sub.  Parent
and Sub hereby jointly and severally represent and warrant to the
Stockholders as follows:

                  (a) Authority. Parent and Sub have all requisite corporate
         power and authority to execute and deliver this Agreement and to
         consummate the transactions contemplated hereby. The execution,
         delivery and performance of this Agreement by each of Parent and Sub,
         and the consummation of the transactions contemplated hereby, have been
         duly authorized by all necessary corporate action on the part of each
         of Parent and Sub. This Agreement has been duly executed and delivered
         by Parent and Sub and constitutes a valid and binding obligation of
         Parent and Sub enforceable against Parent and Sub in accordance with
         its terms. Except for the expiration or termination of the applicable
         waiting periods under the Merger Control Laws and required filings with
         the Securities and Exchange Commission, the execution and delivery of
         this Agreement do not, and the consummation by Parent and Sub of the
         transactions contemplated hereby and compliance with the terms hereof
         will not, (i) conflict with, or result in any violation of, or default
         (with or without notice or lapse of time or both) under any provision
         of, any trust agreement, loan or credit agreement, note, bond,
         mortgage, indenture, lease or other agreement, instrument, permit,
         concession, franchise, license, judgment, order, notice, decree,
         statute, law, ordinance, rule or regulation applicable to Parent or Sub
         or to the property or assets of Parent or Sub, (ii) require any filing
         with, or permit, authorization, consent or approval of, any Federal,
         state or local government or any court, tribunal, administrative agency
         or commission or other governmental or regulatory authority or agency,
         domestic, foreign or supranational, or (iii) violate any order, writ,
         injunction, decree, statute, rule or regulation applicable to Parent or
         Sub or any of the properties or assets of Parent or Sub.

                  (b) Securities Act. The Subject Shares will be acquired in
         compliance with, and Sub will not offer to sell or otherwise dispose of
         any Shares so acquired by it in violation of the registration
         requirements of, the Securities Act of 1933, as amended.

                  (c) Financing. Sub has, or will have at the time that any
         payment is required to be made to any Stockholder hereunder, the funds
         necessary to make such payment to such Stockholder.

                  (d) Brokers. No broker, investment banker, financial advisor
         or other person, other than Credit Suisse First Boston Corporation, the
         fees and expenses of which will be paid by Parent, is entitled to any
         broker's, finder's, financial advisor's or other similar fee or
         commission in connection with the transactions contemplated by this
         Agreement based upon arrangements made by or on behalf of Parent or
         Sub.

                 4.  Covenants of Stockholders.  The Stockholders jointly
and severally agree as follows:

                  (a) At any meeting of stockholders of the Company called to
         vote upon the Merger and the Merger Agreement or at any adjournment
         thereof or in any other circumstances upon which a vote, consent or
         other approval (including by written consent) with respect to the
         Merger and the Merger Agreement is sought, the Stockholders shall vote
         (or cause to be voted) the Subject Shares in favor of the Merger, the
         adoption by the Company of the Merger Agreement and the approval of the
         terms thereof and each of the other transactions contemplated by the
         Merger Agreement; provided that no amendment to the Merger Agreement
         will be made that creates additional Offer Conditions, reduces the
         Offer Price or otherwise adversely affects the Stockholders without the
         prior approval of the Stockholders.

                  (b) At any meeting of stockholders of the Company or at any
         adjournment thereof or in any other circumstances upon which the
         Stockholders' votes, consents or other approvals are sought, the
         Stockholders shall vote (or cause to be voted) the Subject Shares
         against (i) any Takeover Proposal (as such term is defined in Section
         6.02 of the Merger Agreement) and (ii) any amendment of the Company's
         Certificate of Incorporation or Bylaws or other proposal or transaction
         involving the Company, which amendment or other proposal or transaction
         would be reasonably likely to impede, frustrate, prevent, delay or
         nullify the Offer, the Merger, the Merger Agreement or any of the other
         transactions contemplated by the Merger Agreement or change in any
         manner the voting rights of any class of Company Common Stock. The
         Stockholders further agree not to enter into any agreement inconsistent
         with the foregoing.

                  (c) The Stockholders shall not (i) sell, transfer, give,
         pledge, assign or otherwise dispose of (including by gift)
         (collectively, "Transfer"), or consent to any Transfer of, any or all
         of such Subject Shares or any interest therein or enter into any
         contract, option or other arrangement (including any profit sharing
         arrangement) with respect to the Transfer of, the Subject Shares to any
         person other than pursuant to the terms of the Offer or the Merger or
         otherwise to Sub in accordance with Section 1 or (ii) enter into any
         voting arrangement, whether by proxy, voting agreement, voting trust,
         power-of-attorney or otherwise, with respect to the Subject Shares in
         connection with, directly or indirectly, any Takeover Proposal. The
         Stockholders shall not commit or agree to take any of the foregoing
         actions.

                  (d) The Stockholders shall not, and shall use their reasonable
         efforts to cause any investment banker, financial advisor, attorney,
         accountant or other representative of any such Stockholder not to,
         directly or indirectly, (i) solicit, initiate or encourage (including
         by way of furnishing information), or take any other action to
         facilitate, any inquiries or the making of any proposal that
         constitutes, or may reasonably be expected to lead to, any Takeover
         Proposal or (ii) participate in any discussions or negotiations
         regarding any Takeover Proposal.

                 5.  Grant of Irrevocable Proxy;  Appointment of Proxy.
(a)  Each Stockholder hereby irrevocably grants to, and appoints, Parent
and James R.  Utaski and Peter S.  Galloway, in their respective capacities
as officers of Parent, and any individual who shall hereafter succeed to
any such office of Parent, and each of them individually, such
Stockholder's proxy and attorney-in-fact (with full power of substitution),
for and in the name, place and stead of such Stockholder, to vote such
Stockholder's Subject Shares, or grant a consent or approval in respect of
such Subject Shares against (i) any Takeover Proposal or (ii) any amendment
of the Company's Certificate of Incorporation or Bylaws, or other proposal
or transaction (including any consent solicitation to remove or elect any
directors of the Company) involving the Company which amendment or other
proposal or transaction would be reasonably likely to impede, frustrate,
prevent, delay or nullify the Offer, the Merger, the Merger Agreement or
any of the other transactions contemplated by the Merger Agreement.

                  (b) Each Stockholder represents that any proxies heretofore
given in respect of such Stockholder's Subject Shares are not irrevocable, and
that any such proxies are hereby revoked.

                  (c) Each Stockholder hereby affirms that the irrevocable proxy
set forth in this Section 5 is given in connection with the execution of the
Merger Agreement, and that such irrevocable proxy is given to secure the
performance of the duties of such Stockholder in accordance with this Agreement.
Such Stockholder hereby further affirms that the irrevocable proxy is coupled
with an interest and may under no circumstances be revoked. Such Stockholder
hereby ratifies and confirms all that such irrevocable proxy may lawfully do or
cause to be done by virtue hereof. Such irrevocable proxy is executed and
intended to be irrevocable in accordance with the provisions of Section 212(e)
of the Delaware General Corporation Law (the "DGCL"). Such irrevocable proxy
shall be valid until the earlier to occur of (i) eleven months from the date
hereof or (ii) the termination of this Agreement pursuant to Section 9.

                  (d) Any action taken by Parent pursuant to the proxy granted
under Section 5(a)(ii) shall provide that the Stockholders may revoke such
action effective upon termination of the Merger Agreement.

                 6.  Further Assurances.  Upon the terms and subject to the
conditions set forth in this Agreement, each of the parties agrees to use
all reasonable efforts (as described in Section 7.03(a) of the Merger
Agreement) to consummate and make effective, in the most expeditious manner
practicable, the Offer and the Merger, and the other transactions
contemplated by this Agreement and the Merger Agreement.

                 7.  Certain Events.  (a)  Each Stockholder agrees that
this Agreement and the obligations hereunder shall attach to such
Stockholder's Subject Shares and shall be binding upon any person or entity
to which legal or beneficial ownership of such Subject Shares shall pass,
whether by operation of law or otherwise, including such Stockholder's
administrators or successors.  In the event of any stock split, stock
dividend, merger, reorganization, recapitalization or other change in the
capital structure of the Company affecting the Company Common Stock, or the
acquisition of additional shares of Company Common Stock or other voting
securities of the Company by any Stockholder, the number of Subject Shares
listed in Schedule A beside the name of such Stockholder shall be deemed
adjusted appropriately and this Agreement and the obligations hereunder
shall attach to any additional shares of Company Common Stock or other
voting securities of the Company issued to or acquired by such Stockholder.

                  (b) Each Stockholder agrees that it will deliver to the
Company, within 10 business days after the date hereof (or, in the event Subject
Shares are acquired subsequent to the date hereof within 10 business days after
the date of such acquisition), any and all certificates representing such
Stockholder's Subject Shares solely for the purpose of the Company inscribing
upon such certificates the legend in accordance with Section 7.13 of the Merger
Agreement.

                 8.  Assignment.  Neither this Agreement nor any of the
rights, interests or obligations hereunder shall be assigned by any of the
parties without the prior written consent of the other parties, except that
(i)  Sub may assign, in its sole discretion, any or all of its rights,
interests and obligations hereunder to any U.S. subsidiary of Parent that
may be substituted for Sub as contemplated by Section 2.01 of the Merger
Agreement, and (ii)  Parent may assign, in its sole discretion, any and all
of its rights, interests and obligations hereunder to any direct or
indirect wholly owned subsidiary of Parent, provided that Parent will
remain liable for its obligations hereunder in the event of any assignment
pursuant to this clause (ii).  Subject to the preceding sentence, this
Agreement will be binding upon, inure to the benefit of and be enforceable
by the parties and their respective successors and assigns.

                 9.  Termination.  (a)  This Agreement, and all rights and
obligations of the parties hereunder, shall terminate upon the date upon
which the Merger Agreement is terminated in accordance with its terms.
Notwithstanding the foregoing, Sections 8, 9 and 10 shall survive any
termination of this Agreement.

                  (b) Notwithstanding Section 9(a) above, Stockholders may
terminate this Agreement in the event the Company has the right to terminate the
Merger Agreement pursuant to Section 9.01(b) thereof.

                10.  General Provisions.

                  (a)  Amendments.  This Agreement may not be amended
         except by an instrument in writing signed by each of the parties
         hereto.

                  (b) Notice. All notices and other communications hereunder
         shall be in writing and shall be deemed given if delivered personally,
         telecopied (which is confirmed), sent by overnight courier (providing
         proof of delivery) or mailed by registered or certified mail (return
         receipt requested) to Parent and Sub in accordance with Section 10.02
         of the Merger Agreement and to the Stockholders at their respective
         addresses or telecopier numbers set forth on Schedule A attached hereto
         (or at such other address or telecopier number for a party as shall be
         specified by like notice).

                  (c) Interpretation. When a reference is made in this Agreement
         to Sections, such reference shall be to a Section to this Agreement
         unless otherwise indicated. The headings contained in this Agreement
         are for reference purposes only and shall not affect in any way the
         meaning or interpretation of this Agreement. Wherever the words
         "include", "includes" or "including" are used in this Agreement, they
         shall be deemed to be followed by the words "without limitation".
         Capitalized terms used and not otherwise defined in this Agreement
         shall have the respective meanings assigned to them in the Merger
         Agreement.

                  (d) Counterparts. This Agreement may be executed in one or
         more counterparts, all of which shall be considered one and the same
         agreement, and shall become effective when one or more of the
         counterparts have been signed by each of the parties and delivered to
         the other party, it being understood that each party need not sign the
         same counterpart.

                  (e) Entire Agreement; No Third-Party Beneficiaries. This
         Agreement (including the documents and instruments referred to herein)
         (i) constitutes the entire agreement and supersedes all prior
         agreements and understandings, both written and oral, among the parties
         with respect to the subject matter hereof and (ii) is not intended to
         confer upon any person other than the parties hereto any rights or
         remedies hereunder.

                  (f) Governing Law. This Agreement shall be governed by, and
         construed in accordance with, the laws of the State of Delaware
         regardless of the laws that might otherwise govern under applicable
         principles of conflicts of law thereof.

                  (g) Severability. If any term or other provision of this
         Agreement is invalid, illegal or incapable of being enforced by any
         rule of law or public policy, all other conditions and provisions of
         this Agreement shall nevertheless remain in full force and effect. Upon
         such determination that any term or other provision is invalid, illegal
         or incapable of being enforced, the parties hereto shall negotiate in
         good faith to modify this Agreement so as to effect the original intent
         of the parties as closely as possible to the fullest extent permitted
         by applicable law in an acceptable manner to the end that the
         transactions contemplated hereby are fulfilled to the extent possible.

                11.  Enforcement.  The parties agree that irreparable
damage would occur in the event that any of the provisions of this
Agreement were not performed in accordance with their specific terms or
were otherwise breached.  It is accordingly agreed that the parties shall
be entitled to an injunction or injunctions to prevent breaches of this
Agreement and to enforce specifically the terms and provisions of this
Agreement in any court of the United States located in the State of
Delaware or in a Delaware state court, this being in addition to any other
remedy to which they are entitled at law or in equity.  In addition, each
of the parties hereto (i) consents to submit such party to the personal
jurisdiction of any Federal court located in the State of Delaware or any
Delaware state court in the event any dispute arises out of this Agreement
or any of the transactions contemplated hereby, (ii) agrees that such party
will not attempt to deny or defeat such personal jurisdiction by motion or
other request for leave from any such court, (iii) agrees that such party
will not bring any action relating to this Agreement or the transactions
contemplated hereby in any court other than a Federal court sitting in the
State of Delaware or a Delaware state court and (iv) waives any right to
trial by jury with respect to any claim or proceeding related to or arising
out of this Agreement or any of the transactions contemplated hereby.

                12.  Public Announcements.  Parent and Sub, on the one
hand, and the Stockholders, on the other hand, will consult with each other
before issuing, and provide each other with a reasonable opportunity to
review and comment upon, any press release or other public statements with
respect to the transactions contemplated by this Agreement and the Merger
Agreement, including the Offer and the Merger, and shall not issue, or
permit any of their respective subsidiaries to issue, any such press
release or make any such public statement prior to such consultation,
except as may be required by applicable law, court process or by
obligations pursuant to any listing agreement with any national securities
exchange or national securities quotation system, in which case the party
making such release will use reasonable efforts to obtain comments from the
other party before issuance of such release or statement.

                13. Indemnification. Parent agrees to indemnify and hold
harmless each Stockholder from all liability for taxes, costs and other expenses
incurred by any Stockholder or any affiliate of any Stockholder (other than the
Company or any of its foreign or domestic subsidiaries) solely as a result of
Parent's exercise of its right to purchase the Company's foreign subsidiaries
prior to the closing of the Offer pursuant to Section 7.14 of the Merger
Agreement, to the extent such taxes, costs or other expenses are in excess of
the taxes, costs or other expenses that would have been incurred by such
Stockholder or such affiliate of such Stockholder (other than the Company or any
of its foreign or domestic subsidiaries) if Parent had not exercised such right
prior to closing of the Offer.

                  IN WITNESS WHEREOF, Parent, Sub and the Stockholders have
caused this Agreement to be duly executed and delivered as of the date first
written above.

                                   JOHNSON & JOHNSON,

                                   By: /s/ James R. Utaski
                                       ------------------------------------
                                       Name:  James R. Utaski
                                       Title: Vice President


                                   LIB ACQUISITION CORP.,

                                   By: /s/ James R. Hilton
                                       ------------------------------------
                                       Name:  James R. Hilton
                                       Title: Vice President


                                   CORANGE LIMITED,

                                   By: /s/ John R. Talbot
                                       ------------------------------------
                                       Name:  John R. Talbot
                                       Title: Director


                                   CORANGE INTERNATIONAL LIMITED,

                                   By: /s/ John R. Talbot
                                       ------------------------------------
                                       Name:  John R. Talbot
                                       Title: Director


                                   CORANGE INTERNATIONAL HOLDING B.V.,

                                   By: /s/ W. J. VAN DER HOEK
                                       ------------------------------------
                                       Name:  W. J. van der Hoek
                                       Title: Directo


                                   PHARMINVEST S.A.,

                                   By: /s/ JURGEN FRIEDRICH
                                       ------------------------------------
                                       Name:  Jurgen Friedrich
                                       Title: President & GM



                                   SCHEDULE A

                                                             Number of Shares
          Name, Address                                     of Company Common
          and Telecopier                                      Stock Owned of
      Number of Stockholder                                       Record
      ---------------------                                 ------------------

Corange Limited                                                  3,168,745
Corner House, Church and Parliament
  Streets
Hamilton HM 12, Bermuda
Attention: President
Tel: ++1 441 295 33 91
Fax: ++1 441 295 41 65

Corange International Limited                                     528,247
Corner House, Church and Parliament
  Streets
Hamilton HM 12, Bermuda
Attention: President
Tel: ++1 441 295 33 91
Fax: ++1 441 295 41 65

Corange International Holding B.V.                               13,272,193
c/o Roche Nederland B.V.
Nijverheidsweg 38
NL-3641 AA Mijdrecht The Netherlands
Attention: General Manager
Tel: ++31 297 29 12 22
Fax: ++31 297 28 31 58

Pharminvest S.A.                                                 66,030,815
145 Rue de Treves
L-2630 Luxembourg, Luxembourg
Attention: President
Tel: ++352 42 2020-1
Fax: ++352 43 10 01



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