PERARDUA CORP
SB-2, 1997-02-05
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    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON FEBRUARY 5, 1997
                                                     REGISTRATION NO. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    Form SB-2
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                              PerArdua Corporation
                 (NAME OF SMALL BUSINESS ISSUER IN ITS CHARTER)
                             ------------------------
            DELAWARE                                          43-1749675       
  (STATE OR OTHER JURISDICTION                                  (I.R.S.        
      OF INCORPORATION OR                                       EMPLOYER       
          ORGANIZATION)                                     IDENTIFICATION NO.)
                                      2836              
                          (PRIMARY STANDARD INDUSTRIAL
                           CLASSIFICATION CODE NUMBER)
                                                         
                             -----------------------

      PERARDUA CORPORATION                             PERARDUA CORPORATION     
    10940 Wilshire Boulevard,                        10940 Wilshire Boulevard,  
           Suite 1600                                       Suite 1600          
  Los Angeles, California 90024                    Los Angeles, California 90024
         (310) 443-4240                                   (310) 443-4240        
  (ADDRESS AND TELEPHONE NUMBER                    (ADDRESS AND TELEPHONE NUMBER
               OF                                               OF              
  PRINCIPAL EXECUTIVE OFFICES)                     PRINCIPAL EXECUTIVE OFFICES) 
                                                  
                              SAMUEL P. SEARS, JR.
                              PERARDUA CORPORATION
                             16 South Market Street
                           Petersburg, Virginia 23803
                                 (804) 861-0681
                          (NAME, ADDRESS AND TELEPHONE
                                     NUMBER
                              OF AGENT FOR SERVICE)

                             -----------------------

                          COPIES OF COMMUNICATIONS TO:

       J. BENJAMIN ENGLISH, ESQ.                     WILLIAM M. PRIFTI, ESQ.
LECLAIR RYAN, A PROFESSIONAL CORPORATION           Lynnfield Woods Office Park
    707 East Main Street, Suite 1100                 220 Broadway, Suite 204
        Richmond, Virginia 23219                  Lynnfield, Massachusetts 01940
             (804) 783-2003                               (617) 593-4525

                            -----------------------

    APPROXIMATE  DATE OF PROPOSED SALE TO THE PUBLIC:  As soon as practicable on
or after the effective date of this Registration Statement.

    If this Form is filed to  register  additional  securities  for an  offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering.[ ]

    If this Form is a  post-effective  amendment  filed  pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering.[ ]

    If delivery of the  prospectus  is expected to be made pursuant to Rule 434,
please check the following box.[ ]

                      CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
==================================================================================================================================
TITLE OF EACH CLASS                                                AMOUNT     PROPOSED MAXIMUM   PROPOSED MAXIMUM       AMOUNT OF 
OF SECURITIES TO BE                                                 TO BE      OFFERING PRICE        AGGREGATE        REGISTRATION
    REGISTERED                                                   REGISTERED     PER UNIT(1)      OFFERING PRICE(1)         FEE
<S>                                                              <C>              <C>                 <C>                <C>
Common Stock(2)                                                  1,150,000          $ 5.00           $ 5,750,000               --
Redeemable Warrants(3)                                           1,150,000          $ 0.10           $   115,000               --
Common Stock issuable upon exercise ofRedeemable Warrants(4)     1,150,000          $ 6.50           $ 7,475,000               --
Representative's Warrants(5)                                             1          $   --           $       100               --
Common Stock issuable upon exercise of                          
 Representative's Warrants(6)                                      100,000          $ 8.00           $   800,000               --
Redeemable Warrants issuable upon exercise of the               
 Representative's Warrants(6)                                      100,000          $ 0.16           $    16,000               --
Common Stock underlying Redeemable Warrants issuable upon       
 exercise of Representative's Warrants(6)                          100,000          $10.40           $ 1,040,000               --
                                                                 
   TOTAL                                                                                             $15,196,100          $ 4,605
==================================================================================================================================
</TABLE>                                                    

(1)  The proposed  maximum offering price is estimated solely for the purpose of
     computing the amount of the registration fee.
(2)  Includes  150,000  shares of Common  Stock that the  Underwriters  have the
     option  to  purchase  to  cover  over-allotments  in  connection  with  the
     Registrant's sale of the securities registered hereby, if any.
(3)  Includes 150,000 Redeemable  Warrants that the Underwriters have the option
     to purchase to cover  over-allotments  in connection with the  Registrant's
     sale of the  securities  registered  hereby,  if any.  Pursuant to Rule 416
     under the Securities  Act of 1933, as amended (the  "Securities  Act"),  an
     indefinite  number  of  additional   Redeemable  Warrants  are  also  being
     registered  to cover any  adjustment  resulting  from the  operation of the
     anti-dilution provisions of the Redeemable Warrants.
(4)  Includes  150,000  shares of Common  Stock  issuable  upon  exercise of the
     Redeemable  Warrants that the  Underwriters  have the option to purchase to
     cover  over-allotments  in  connection  with the  Registrant's  sale of the
     securities  registered hereby, if any. Such shares are being registered for
     resale by the  purchasers  thereof and their assigns and  transferees  on a
     delayed or continuous  basis pursuant to Rule 415 under the Securities Act.
     Pursuant  to Rule 416 under the  Securities  Act, an  indefinite  number of
     additional  shares of Common Stock are also being  registered  to cover any
     adjustment  resulting from the  anti-dilution  provisions of the Redeemable
     Warrants.
(5)  In connection  with the  Registrant's  sale of the shares of the securities
     offered  hereby,  the Registrant is granting to the  representative  of the
     several  underwriters (the  "Representative")  warrants to purchase 100,000
     additional  shares  of  Common  Stock  and  100,000  additional  Redeemable
     Warrants  (the  "Represenative's  Warrants").  The  price to be paid by the
     Representative  for the  Representative's  Warrants is $100.  The  exercise
     price of the  Representative's  Warrants is $8.00 per share of Common Stock
     and $0.16 per Redeemable Warrant.
(6)  Pursuant  to Rule 416 under the  Securities  Act, an  indefinite  number of
     additional  shares of Common  Stock and the  Redeemable  Warrants  are also
     being registered to cover any adjustment  resulting from the  anti-dilution
     provisions of the Representative's Warrants.

     THE REGISTRANT  HEREBY AMENDS THIS  REGISTRATION  STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER  AMENDMENT  WHICH  SPECIFICALLY  STATES  THAT  THIS  REGISTRATION
STATEMENT SHALL  THEREAFTER  BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE  SECURITIES  ACT OF 1933 OR UNTIL THE  REGISTRATION  STATEMENT  SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE  COMMISSION,  ACTING PURSUANT TO SECTION 8(A), MAY
DETERMINE.
================================================================================








                  SUBJECT TO COMPLETION, DATED FEBRUARY 5, 1997

PROSPECTUS
- ----------
                           PERARDUA CORPORATION
                     1,000,000 SHARES OF COMMON STOCK
                       1,000,000 REDEEMABLE WARRANTS

    PerArdua  Corporation  ("PerArdua"  or the  "Company")  hereby  offers  (the
"Offering")  1,000,000 shares of the Company's common stock,  $.01 par value per
share (the "Common Stock"),  and 1,000,000  Redeemable Warrants (the "Redeemable
Warrants").  The Common Stock and the  Redeemable  Warrants  offered  hereby are
sometimes  hereinafter  collectively  referred  to  as  the  "Securities."  Each
Redeemable  Warrant entitles the holder to purchase one share of Common Stock at
a price of  $6.50  per  share  beginning  , 1998 and  ending  2002,  unless  the
Redeemable  Warrants  are  redeemed  by the  Company  as  provided  herein.  The
Redeemable  Warrants are redeemable by the Company at a redemption  rate of $.20
per Redeemable Warrant at any time commencing , 1998 upon 30 days' prior written
notice,  provided  that the average  closing bid price of the  Company's  Common
Stock equals or exceeds $9.00 per share for a 20 consecutive trading day period.
See "DESCRIPTION OF SECURITIES."

    Prior to the Offering,  no public market for the  Securities  existed and no
assurance can be given that any such market will develop after the completion of
the  Offering  or,  that if  developed,  such market  will be  sustained.  It is
currently  anticipated that the initial public offering prices will be $5.00 per
share of  Common  Stock  and $.10 per  Redeemable  Warrant.  For the  method  of
determining  the initial  public  offering  price of the  Securities,  see "RISK
FACTORS" and  "UNDERWRITING."  The Company intends to apply for inclusion of the
shares of Common Stock and the Redeemable Warrants on the Nasdaq SmallCap Market
under the symbols "PRDU" and "PRDUW," respectively.

                           -------------------------
         THE SECURITIES OFFERED HEREBY INVOLVE A HIGH DEGREE OF RISK AND
       IMMEDIATE SUBSTANTIAL DILUTION. INVESTORS SHOULD BE ABLE TO SUSTAIN
           A COMPLETE LOSS OF THEIR INVESTMENT. SEE "RISK FACTORS" AND
             "DILUTION" ON PAGES 6 THROUGH 16 AND 18, RESPECTIVELY.
                           -------------------------

    THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
     AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION, NOR HAS THE
      SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION
          PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
              REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

================================================================================
                                        PRICE TO     UNDERWRITING    PROCEEDS TO
                                         PUBLIC      DISCOUNTS(1)     COMPANY(2)
Per Share                                 $5.00          $.50           $4.50
Per Redeemable Warrant                    $ .10          $.01           $ .09
Total                                  $5,100,000      $510,000      $4,590,000
================================================================================
(1)  Does not reflect additional  compensation to be received in the form of (a)
     a 3%  non-accountable  expense  allowance  in the amount of $153,000  and a
     consulting fee payable to Schneider Securities, Inc., as the representative
     (the  "Representative")  of the Underwriters  (the  "Underwriters")  in the
     amount of $3,000 per month for a period of 36 months and (b) warrants  (the
     "Representative's Warrants") to purchase up to 100,000 additional shares of
     Common Stock and 100,000 Redeemable Warrants at 160% of the public offering
     price of the Securities.  In addition,  the Company has agreed to indemnify
     the Underwriters against certain civil liabilities,  including  liabilities
     under the Securities Act of 1933, as amended (the "Securities Act").
     See "UNDERWRITING."
(2)  Before  deducting  additional  expenses  of  the  Offering  payable  by the
     Company,   estimated   at   $450,000,    including   the   Representative's
     non-accountable  expense  allowance and the  consulting  fee payable to the
     Representative.
(3)  The Company has  granted  the  Underwriters  an option to purchase up to an
     additional  150,000  shares  of  Common  Stock  and/or  150,000  Redeemable
     Warrants on the same terms and conditions set forth above,  solely to cover
     over-allotments, if any. If the over-allotment option is exercised in full,
     the total  "Price to Public,"  "Underwriting  Discounts"  and  "Proceeds to
     Company" will be $5,865,000,  $586,500 and  $5,278,500,  respectively.  See
     "UNDERWRITING."

     The  Securities  are  being  offered  on a "firm  commitment"  basis by the
Underwriters, when, as, and if delivered to and accepted by the Underwriters and
subject to prior  sale,  withdrawal  or  cancellation  of the  Offering  without
notice. It is expected that delivery of certificates representing the Securities
will be made at the clearing offices of Schneider Securities,  Inc., on or about
__________, 1997.

                           SCHNEIDER SECURITIES, INC.

           THE DATE OF THIS PROSPECTUS IS                , 1997.








    IN CONNECTION WITH THIS OFFERING,  THE UNDERWRITERS MAY OVER-ALLOT OR EFFECT
TRANSACTIONS WHICH STABILIZE OR MAINTAIN THE MARKET PRICE OF THE COMMON STOCK OR
THE REDEEMABLE  WARRANTS AT A LEVEL ABOVE THAT WHICH MIGHT OTHERWISE  PREVAIL IN
THE OPEN  MARKET.  SUCH  TRANSACTIONS  MAY BE  EFFECTED  ON THE NASDAQ  SMALLCAP
MARKET. SUCH STABILIZING, IF COMMENCED, MAY BE DISCONTINUED AT ANY TIME.

    PRIOR TO THE  OFFERING,  THE COMPANY WAS NOT A REPORTING  COMPANY  UNDER THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED (THE "EXCHANGE ACT").  SUBSEQUENT TO
THE OFFERING,  THE COMPANY INTENDS TO FURNISH TO ITS SHAREHOLDERS ANNUAL REPORTS
CONTAINING FINANCIAL STATEMENTS AUDITED BY ITS INDEPENDENT ACCOUNTANTS, AND SUCH
OTHER  PERIODIC  REPORTS AS IT MAY DETERMINE TO FURNISH OR AS MAY BE REQUIRED BY
LAW.


                               PROSPECTUS SUMMARY

    The following  summary is qualified in its entirety by reference to the more
detailed  information,  including  "RISK  FACTORS" and the  Company's  financial
statements and related notes thereto appearing elsewhere in this Prospectus. The
Common Stock and  Redeemable  Warrants  offered  hereby involve a high degree of
risk.  Investors  in the Offering  should be able to sustain a complete  loss of
their  investment.   See  "RISK  FACTORS."  This  Prospectus   contains  certain
forward-looking  statements that involve risks and uncertainties.  The Company's
actual  results and the timing of certain  events could differ  materially  from
those discussed in or projected by the forward-looking statements.  Factors that
could cause or contribute to such  differences  include  those  discussed  under
"RISK FACTORS."

                                   THE COMPANY

    The Company is a development  stage  pharmaceutical  company  engaged in the
development  of a single  anti-viral  compound for which the Company has adopted
the trade name  "Thiovir(tm)."  The initial focus of the  Company's  development
activities  will be to  demonstrate  the safety  and  efficacy  of  Thiovir  for
treatment of patients infected with human  immunodeficiency  virus ("HIV"),  the
virus which is the precursor to acquired immunodeficiency syndrome ("AIDS"), and
patients showing active  infection of the  opportunistic  virus  cytomegalovirus
("CMV") which causes blindness and other conditions. CMV is primarily manifested
among  AIDS  patients.  The  Company  believes  that  Thiovir,  if  successfully
developed and approved for sale,  would  constitute a candidate for inclusion in
combination  drug  therapy for  HIV/AIDS  treatment  and would  provide  several
benefits over existing treatments for CMV, particularly its potential ability to
replace more toxic intravenous  treatment with a less toxic oral treatment.  The
only  development  work on Thiovir to date has been  limited to  laboratory  and
animal studies conducted by unaffiliated organizations. Therefore, Thiovir is in
an early  stage  of  development.  See  "Business  -  Targeted  Indications  for
Thiovir."

    In the  United  States,  the use and sale of Thiovir is subject to the rules
and regulations of the United States Food and Drug Administration  ("FDA"),  and
obtaining the necessary FDA approval will require substantial  preclinical tests
and clinical trials. The Company expects to commence clinical trials for Thiovir
in 1997. The Company believes that Thiovir may meet the criteria  established by
the FDA for  accelerated  approval.  As a  result,  the  Company  may be able to
commercialize  Thiovir  in a shorter  time  period  than has  historically  been
applicable for a drug that does not meet the criteria for accelerated  approval.
See "BUSINESS -- Government Regulation."

    Initially,   the   Company   intends  to   maintain   a  limited   corporate
infrastructure    devoted   almost    exclusively   to   the   development   and
commercialization  of Thiovir.  Accordingly,  the Company  will engage  contract
research organizations ("CROs") to conduct preclinical tests and clinical trials
on Thiovir.  The Company will also contract with other  companies to manufacture
the drug.  The Company  intends to rely upon part-time  consultants  and CROs to
provide  expertise in designing  appropriate tests and trials and in seeking FDA
and other government approval. Furthermore, the Company does not believe that it
will be necessary to develop an extensive  sales and marketing  force to promote
the sale of Thiovir in the United States,  if and when it may be sold, since the
market for HIV/AIDS and CMV therapies is concentrated  among a relatively  small
number of care providers.

    In August  1996,  the Company  acquired an  exclusive  worldwide  license to
proprietary  rights to Thiovir  held by the  University  of Southern  California
("USC") from a limited  partnership which funded the research and development of
Thiovir. The Company had generated no revenues from the sale of products and, as
of November 30, 1996, had an accumulated deficit of $2,090,690.  There can be no
assurance that the Company will ever achieve profitable operations.

    On January 9, 1997, the Company reincorporated in the State of Delaware. The
term  "Company,"  when  used in this  Prospectus,  refers  to both the  Delaware
corporation  and  its  prededessor  Missouri  corporation,  unless  the  context
requires  otherwise.  The  Company's  offices  are  located  at  10940  Wilshire
Boulevard,  Suite 1600,  Los Angeles,  California,  and its telephone  number is
(310) 443-4240.




                                       3




                                  THE OFFERING

Securities Offered by the 
  Company.................  1,000,000  shares  of  Common  Stock  and  1,000,000
                              Redeemable    Warrants.    See   "DESCRIPTION   OF
                              SECURITIES."

Redeemable Warrants.......  Each  Redeemable  Warrant  entitles  the  holder  to
                              purchase  one share of Common  Stock at a price of
                              $6.50  per  share  beginning  , 1998 and  ending ,
                              2002, unless the Redeemable  Warrants are redeemed
                              as provided  herein.  The Redeemable  Warrants are
                              redeemable by the Company at a redemption price of
                              $.20 per Redeemable Warrant at any time commencing
                              thirteen  months from the date of this  Prospectus
                              on 30 days' prior  written  notice,  provided that
                              the average  closing bid price of the Common Stock
                              equals   or   exceeds   $9.00  per  share  for  20
                              consecutive  trading  days  ending  within 10 days
                              prior   to   the   notice   of   redemption.   See
                              "DESCRIPTION OF SECURITIES."

Shares of Common Stock
  Outstanding 
  before Offering(1)......  2,643,440 shares

Shares of Common Stock to
  be Outstanding
  after Offering(1).......  3,643,440 shares

Use of Proceeds...........  The net proceeds of this  Offering  will be used for
                              further   research  and  development  and  working
                              capital. See "USE OF PROCEEDS."

Risk Factors..............  Investment in the Securities  involves a high degree
                              of risk and immediate dilution. See "RISK FACTORS"
                              and "DILUTION."

Proposed Nasdaq SmallCap
  Market Symbols(2).......  Common Stock  --  "PRDU"  
                            Redeemable Warrants  --  "PRDUW"
- --------
(1) Includes  50,000 shares of Common Stock  subscribed for but not issued as of
    February 5, 1997  pursuant to two private  offerings to the same  individual
    (the "Pending Shares").  Of these shares,  21,560 shares were subscribed for
    as of November 30, 1996.
(2) No assurance can be given that an active  trading  market for the Securities
    will  develop or be  maintained.  See "RISK  FACTORS -- No Prior  Market for
    Common Stock and the Redeemable Warrants."

    Except  as  otherwise  indicated,  all  share  and  per  share  data in this
Prospectus  (i) assume no  exercise  of the  Redeemable  Warrants,  (ii) give no
effect to the  300,000  shares of Common  Stock  issuable  upon  exercise of the
Underwriters'  over-allotment  option,  including 150,000 shares of Common Stock
underlying the Redeemable Warrants subject to such option;  (iii) give no effect
to 100,000 shares of Common Stock issuable upon exercise of the Representative's
Warrants;  (iv) give no effect to the 100,000  shares of Common  Stock  issuable
upon the exercise of the Redeemable  Warrants  underlying  the  Representatives'
Warrants;  (v) assume no  exercise  of stock  options to  purchase up to 500,000
shares of Common  Stock  which may be issued  pursuant  to the  Company's  Stock
Incentive  Plan, of which,  as of the date of this  Prospectus,  the Company has
granted  options  to  purchase  10,000  shares  of  Common  Stock of which at an
exercise  price of $7.50  per  share  and  committed  to grant to three  outside
directors  options to purchase an aggregate of 30,000  shares of Common Stock at
an exercise price to be determined,  but not less than $5.00 per share; and (vi)
assume no exercise of the Company's  outstanding  warrants to purchase shares of
Common Stock, of which 700,000  warrants have been issued as of the date of this
Prospectus  at  an  exercise  price  of  $10.00  per  share  (the   "Outstanding
Warrants").  See "CAPITALIZATION" and "MANAGEMENT -- Executive  Compensation and
Other Information -- Stock Incentive Plan."



                                       4



                       SUMMARY FINANCIAL INFORMATION

    The following  sets forth certain  historical  financial  information of the
Company:

STATEMENT OF ACTIVITIES DATA:
                                                       PERIOD FROM JULY 5, 1996,
                                                         DATE OF INCEPTION, TO
                                                           NOVEMBER 30, 1996
                                                        -----------------------
Revenue:
    Interest income                                           $     1,858
                                                              -----------
Costs and Expense:
    Research and development                                    2,058,980
    General and administrative                                     33,568
                                                              -----------
                                                                2,092,548
                                                              -----------
Net loss                                                       (2,090,690)
                                                              ===========
Net loss per common share (1)                                 $      (.81)
                                                              ===========
Shares used in computing net loss per common share (1)          2,593,440
                                                              ===========

BALANCE SHEET DATA:

                                                         NOVEMBER 30, 1996
                                                    ----------------------------
                                                      ACTUAL      AS ADJUSTED(2)
                                                    ----------   ---------------
Cash and cash equivalents                         $   495,421     $ 4,715,421
Working capital                                       503,621       4,723,621
Total assets                                          532,005       4,752,005
Deficit accumulated during the development stage   (2,090,690)     (2,090,690)
Total stockholders' equity                            510,487       4,730,487

- --------
(1)  See  notes  1  and 4 of  Notes  to  Financial  Statements  for  information
     concerning the  computation of net loss per common share and shares used in
     computing net loss per common share.

(2)  As  adjusted  to reflect  the sale of the Common  Stock and the  Redeemable
     Warrants  offered hereby and the  application of the estimated net proceeds
     therefrom and the issuance of the Pending Shares. See "USE OF PROCEEDS."



                                       5




                                  RISK FACTORS

    The  Securities  offered  pursuant to this  Prospectus are  speculative  and
involve a high degree of risk,  and an  investment in the  Securities  should be
considered  only by investors who are capable of affording an entire loss of the
amount invested. Prospective investors should carefully consider, along with the
other information contained in this Prospectus, the following considerations and
risks in evaluating an investment in the Company.

DEVELOPMENT STAGE COMPANY

    The  Company  commenced  development  stage  activities  in  July  1996  and
accordingly has only a limited operating history upon which an evaluation of the
Company's  business and  prospects  can be based.  The Company has  generated no
revenue to date, except for interest income, and does not expect to generate any
substantial  revenues  in the near  future.  The  Company's  ability to generate
revenues and profits will depend on its ability to successfully develop clinical
applications and obtain regulatory approvals for the anti-viral drug Thiovir and
to protect its proprietary rights in Thiovir.  The Company must also develop the
capacity or  arrangements  with third  parties to  manufacture,  distribute  and
market Thiovir. There can be no assurance that the Company will be successful in
doing so. See "BUSINESS -- Overview."

INDEPENDENT AUDITORS' REPORT CONTAINS GOING CONCERN EMPHASIS PARAGRAPH

    The report of the  Company's  Independent Auditors contains  an
emphasis  paragraph  as to  matters  that  raise  substantial  doubt  about  the
Company's ability to continue as a going concern, and management's  inability to
provide any  assurance  that the Company  will obtain  sufficient  financing  to
continue  as a going  concern.  See  "MANAGEMENT'S  DISCUSSION  AND  ANALYSIS OF
FINANCIAL   CONDITION  AND  RESULTS  OF  OPERATIONS,"  the  Company's  Financial
Statements and Notes and the Independent Auditor's Report included herein.

UNCERTAINTY OF PRODUCT DEVELOPMENT

    Thiovir  is  in an  early  developmental  stage  and  requires  significant,
time-consuming  and  costly  development,   testing  and  regulatory  clearance.
Although the Company anticipates that the development and  commercialization  of
Thiovir,  if  successful,  will occur  more  rapidly  than is typical  for a new
pharmaceutical  product, this process typically takes several years at a minimum
and can require  substantially more time. The successful  development of any new
drug is highly  uncertain and subject to a number of  significant  risks.  These
risks include,  among others,  the possibility  that Thiovir will be found to be
ineffective  or  unacceptably  toxic  or  otherwise  fail to  receive  necessary
regulatory  clearances,  that Thiovir will not achieve broad market  acceptance,
that third parties will market  equivalent or superior  products,  or that third
parties  will hold  proprietary  rights  that will  preclude  the  Company  from
marketing  Thiovir.  There can be,  therefore,  no assurance  that the Company's
development  activities will demonstrate the efficacy and safety of Thiovir as a
therapeutic  drug,  or,  even if  demonstrated,  that there  will be  sufficient
advantages  to the use of Thiovir over other drugs or treatments so as to render
Thiovir  commercially viable. See "BUSINESS -- Targeted Indications for Thiovir"
and "-- Government Regulation."

RELIANCE ON A SINGLE TECHNOLOGY; LIMITED SCOPE OF OPERATIONS

    The  Company  currently  intends to focus its  business  exclusively  on the
development and commercialization of the experimental drug Thiovir. In the event
the  Company  is not  successful  in  developing  and  commercializing  Thiovir,
investors are likely to realize a loss of all amounts invested in the Company.

ACCUMULATED DEFICIT; UNCERTAINTY OF FUTURE PROFITABILITY

    The Company has  incurred  losses  since its  inception.  As of November 30,
1996, the Company's  accumulated  deficit was  $2,090,690.  Losses have resulted
principally  from costs incurred in the  acquisition  and development of Thiovir
and general and  administrative  costs.  These costs have exceeded the Company's
revenues,  which to date have been generated  solely from interest  income.  The
Company  has not




                                       6




generated  any  revenue to date from the sale of drugs and does not expect to do
so until  Thiovir  has been  approved  for sale.  The  Company  expects to incur
significant  additional  operating  losses which will  increase as the Company's
drug development efforts expand. The Company's ability to achieve  profitability
will  depend  upon its ability to develop  and obtain  regulatory  approval  for
Thiovir and to develop  the  capacity  (or  establish  relationships  with third
parties) to manufacture, market and sell Thiovir. There can be no assurance that
the  Company  will ever  generate  significant  revenues  or achieve  profitable
operations.  See "BUSINESS -- Government  Regulation," "-- Sales and Marketing,"
and "-- Manufacturing."

FUTURE CAPITAL NEEDS; UNCERTAINTY OF ADDITIONAL FUNDING

    The  Company's  drug  development   program  requires   substantial  capital
expenditures, including expenditures for preclinical testing and clinical trials
of  Thiovir.  The  Company's  future  capital  requirements  will depend on many
factors,  including  the scope and results of  preclinical  testing and clinical
trials, the cost, timing and outcome of regulatory  reviews,  administrative and
legal  expenses  (including  potential  expenses of defending  and enforcing the
Company's  proprietary patent rights to Thiovir),  the establishment of capacity
for sales and marketing functions, the establishment of relationships with third
parties for manufacturing  and sales and marketing  functions and other factors.
The Company expects that its capital requirements will increase significantly in
the future.  See "BUSINESS -- Government  Regulation,"  "-- Sales and Marketing"
and "-- Manufacturing."

    The  Company  has  incurred   negative  cash  flow  from  development  stage
activities since inception and does not expect to generate positive cash flow to
fund its  operations  for at least the next  several  years.  As a  result,  the
Company  believes that  substantial  additional  equity or debt financing may be
required to fund its operations. There can be no assurance that the Company will
be able to consummate  any such  financing at all or on favorable  terms or that
such financings will be adequate to meet the Company's capital requirements. Any
additional  equity  financing  could  result  in  substantial  dilution  to  the
Company's  stockholders,   and  debt  financing,   if  available,   may  involve
restrictive  covenants which preclude the Company from making  distributions  to
stockholders and taking other actions  beneficial to  stockholders.  If adequate
funds are not  available,  the  Company  may be  required to delay or reduce the
scope of its drug  development  program or attempt to  continue  development  by
entering  into  arrangements  with  collaborative  partners  or others  that may
require the  Company to  relinquish  some or all of its rights to  Thiovir.  The
Company's  inability  to fund its  capital  requirements  would  have a material
adverse effect on the Company. See "USE OF PROCEEDS" and "DILUTION."

EXTENSIVE GOVERNMENT REGULATION; NO ASSURANCE OF REGULATORY APPROVAL

    Human  pharmaceutical  products are subject to rigorous  preclinical testing
and  clinical  trials  and other  approval  procedures  mandated  by the FDA and
foreign  regulatory  authorities.  Various  federal  and  foreign  statutes  and
regulations  also  govern or  influence  the  manufacturing,  safety,  labeling,
storage, record keeping and marketing of pharmaceutical products. The process of
obtaining these approvals and the subsequent  compliance with appropriate United
States and foreign statutes and regulations are  time-consuming  and require the
expenditure  of  substantial  resources.  In addition,  these  requirements  and
processes vary widely from country to country. Among the uncertainties and risks
of the FDA approval process are the following:  the possibility that studies and
clinical trials shall fail to prove the safety and efficacy of the drug, or that
any  demonstrated  efficacy  will be so  limited as to  significantly  reduce or
altogether  eliminate the  acceptability  of the drug in the market  place;  the
possibility  that the costs of  development,  which can far  exceed  the best of
estimates, may render  commercialization  of the drug  marginally  profitable or
altogether  unprofitable;  and the possibility  that the amount of time required
for FDA approval of a drug may extend for years beyond that which is  originally
estimated.  In addition,  the FDA or similar foreign regulatory  authorities may
require  additional  clinical trials,  which could result in increased costs and
significant  development  delays.  Delays or rejections  may also be encountered
based upon changes in FDA policy and the establishment of additional regulations
during the period of  product  development  and FDA  review.  Similar  delays or
rejections may be encountered  in other  countries.  Thiovir may not qualify for
accelerated  development  and/or  approval  under FDA  regulations  and, even if
Thiovir does so qualify,  it may not be approved for marketing sooner than would
be historically expected or at all.



                                       7




    There can be no assurance that even after substantial time and expenditures,
Thiovir will receive FDA approval on a timely basis or at all. If the Company is
unable  to  demonstrate  the  safety  and   effectiveness   of  Thiovir  to  the
satisfaction  of the FDA, the Company will be unable to  commercialize  Thiovir.
Even if  regulatory  approval of Thiovir is  obtained,  the  approval may entail
limitations on the indicated uses for which Thiovir may be marketed.  A marketed
product,  its  manufacturer  and the  manufacturer's  facilities  are subject to
continual  review  and  periodic   inspections,   and  subsequent  discovery  of
previously unknown problems with a product,  manufacturer or facility may result
in restrictions  on such product or  manufacturer,  including  withdrawal of the
product  from the  market.  The  failure to comply  with  applicable  regulatory
requirements can, among other things, result in fines,  suspension of regulatory
approvals,  refusal to approve pending  applications,  refusal to permit exports
from  the  United  States,  product  recalls,  seizure  of  products,  operating
restrictions and criminal prosecutions.

    The  effect of  governmental  regulation  may be to delay the  marketing  of
Thiovir for a considerable  period of time, to impose costly requirements on the
Company's activities or to provide a competitive advantage to the companies that
compete  with the  Company.  Adverse  clinical  results  by others  could have a
negative  impact on the  regulatory  process  and  timing  with  respect  to the
development  and  approval  of Thiovir.  The Company is also  subject to various
federal,  state  and  local  laws  and  regulations  relating  to  safe  working
conditions,  laboratory and  manufacturing  practices,  the  experimental use of
animals  and  the  use  and  disposal  of  hazardous  or  potentially  hazardous
substances,  including radioactive compounds and infectious disease agents, used
in connection with its development work. The extent and character of potentially
adverse  governmental  regulation  that may arise  from  future  legislation  or
administrative   action  cannot  be  predicted.   See  "BUSINESS  --  Government
Regulation."

UNCERTAINTIES RELATED TO CLINICAL TRIALS

    Before obtaining  required  regulatory  approvals for the commercial sale of
Thiovir,  the Company must demonstrate  through preclinical testing and clinical
trials that Thiovir is safe and effective for use in each target indication. The
results from preclinical testing and early clinical trials may not be predictive
of results  that will be obtained in pivotal  clinical  trials.  There can be no
assurance that the Company's clinical trials will demonstrate  sufficient safety
and  effectiveness to obtain required  regulatory  approvals or will result in a
marketable  product. A number of companies in the  pharmaceutical  industry have
suffered  significant setbacks in advanced clinical trials, even after promising
results in earlier  trials.  Similar  setbacks in the Company's  clinical trials
could interrupt,  delay or halt clinical trials and could ultimately prevent its
approval by the FDA or foreign  regulatory  authorities for any and all targeted
indications.  The Company or the FDA may suspend or terminate clinical trials at
anytime  if it is  believed  that the trial  participants  are being  exposed to
unacceptable  health risks.  There can be no assurance that clinical trials will
demonstrate that Thiovir is safe and effective.

    There  can  be  no  assurance  that  if  clinical  trials  are  successfully
completed,  the Company will be able to submit a New Drug Application ("NDA") in
a timely  manner or that any such  application  will be approved by the FDA. Any
failure of the Company to complete  successfully  its clinical trials and obtain
approvals of corresponding NDAs would preclude the Company from  commercializing
Thiovir in the United States. See "BUSINESS -- Government Regulation."

INTENSE COMPETITION; RISK OF TECHNOLOGICAL CHANGE

    The Company is engaged in a segment of the  pharmaceutical  industry that is
highly competitive and rapidly changing. If successfully developed and approved,
Thiovir  will  compete with several  existing  HIV/AIDS  and CMV  therapies.  In
addition,  other companies are pursuing the development of pharmaceuticals  that
target  HIV/AIDS and/or CMV. The Company  anticipates  that it will face intense
and  increasing  competition  in the future as new products enter the market and
advanced technologies become available.  There can be no assurance that existing
products or new products developed by the Company's competitors will not be more
effective,  or more  effectively  marketed and sold,  than Thiovir.  Competitive
products may render Thiovir  obsolete or  noncompetitive  prior to the Company's
recovery of development or commercialization expenses. The Company's competitors
have significantly greater financial, technical and human




                                       8




resources  than the Company and may be better  equipped to develop,  manufacture
and  market  products.  In  addition,  many of these  companies  have  extensive
experience in preclinical  testing and clinical trials,  obtaining FDA and other
regulatory  approvals and manufacturing and marketing  pharmaceutical  products.
Many of these  competitors  also have products that have been approved or are in
late-stage  development and operate large,  well-funded research and development
programs.  Smaller  companies  may  also  prove to be  significant  competitors,
particularly  through  collaborative  arrangements with large pharmaceutical and
biotechnology companies. Furthermore, academic institutions, government agencies
and other public and private research  organizations  are becoming  increasingly
aware of the commercial  value of their  inventions and are actively  seeking to
commercialize  the technology  they have developed.  Accordingly,  the Company's
competitors may succeed in commercializing  products more rapidly or effectively
than the Company, which would have a material adverse effect on the Company. See
"BUSINESS -- Potential Market for Thiovir."

    The  Company  believes  that  Thiovir  may be an  attractive  candidate  for
combination drug therapy in HIV/AIDS patients. Considerable additional research,
however,  is necessary  to validate  this  belief.  There have been  significant
recent  developments in the use of combination  drug therapy  designed to arrest
the  development  of HIV.  The Company  believes  that a  significant  number of
additional  drugs are currently under  development and will become  available in
the future for the  treatment  of HIV. It is  uncertain  what  effect  these new
developments  in the  treatment  or  prevention  of HIV will have on demand  for
Thiovir as a treatment for CMV. Should treatment  modalities be identified which
would  effectively  reduce or eliminate  the  incidence of CMV active  infection
among AIDS patients,  the potential market for Thiovir, as a part of combination
drug  therapy  or as a CMV  treatment,  may be  significantly  reduced  or  even
eliminated, which would have material adverse effect on the Company.

    The  ability of the HIV and CMV viruses to develop  resistance  to drugs has
reduced or eliminated the  effectiveness of a number of existing drugs.  Even if
Thiovir should initially prove effective,  its  effectiveness  and acceptance in
the marketplace  may be reduced by the  development of resistant  strains of the
HIV and CMV viruses.

UNCERTAINTY OF PATENTS; DEPENDENCE ON PATENTS, LICENSES AND PROPRIETARY RIGHTS

    The  Company's  success  will  depend in large  part on the  ability  of the
Company and its licensors to obtain patent  protection  with respect to Thiovir,
defend  patents  once  obtained,  maintain  trade  secrets and  operate  without
infringing  upon the  patents  and  proprietary  rights  of  others  and  obtain
appropriate  licenses to patents or proprietary  rights held by third parties if
infringement  would  otherwise  occur,  both in the United States and in foreign
countries.  The Company has no patents in its own name or patent applications of
its own  pending,  but has  obtained an  exclusive  license to patents and other
proprietary rights from USC with respect to Thiovir.

    The patent  positions of  pharmaceutical  companies,  including those of the
Company, are uncertain and involve complex legal and factual questions for which
important legal  principles are  unresolved.  There can no be assurance that the
Company or its licensor have or will develop or obtain the rights to products or
processes that are  patentable,  that patents will issue from any of the pending
applications or that claims allowed will be sufficient to protect the technology
licensed to the Company. In addition, no assurance can be given that any patents
issued  to or  licensed  by the  Company  will not be  challenged,  invalidated,
infringed or  circumvented,  or that the rights granted  thereunder will provide
competitive advantages to the Company.

    There can be no assurance that the Company is aware of all patents or patent
applications  that may materially  affect the Company's  ability to make, use or
sell Thiovir.  United States patent  applications are confidential while pending
in the United  States  Patent  and  Trademark  Office  (the  "PTO"),  and patent
applications  filed in foreign countries are often first published six months or
more after filing. Any conflicts  resulting from third party patent applications
and patents  could  significantly  reduce the  coverage of the patents or patent
applications licensed to the Company and limit the ability of the Company or its
licensors to obtain meaningful patent protection. If patents are issued to other
companies that contain  competitive or  conflicting  claims,  the Company may be
required to obtain licenses to these patents or to develop or obtain alternative
technology.  There can be no  assurance  that the Company will be able to obtain
any



                                       9




such license on  acceptable  terms or at all. If such licenses are not obtained,
the Company could be delayed in or prevented  from pursuing the  development  or
commercialization of Thiovir.  

    Litigation which could result in substantial cost to the Company may also be
necessary  to  enforce  any  patents  to which the  Company  has  rights,  or to
determine the scope, validity and unenforceability of other parties' proprietary
rights which may affect the Company's  rights to Thiovir  United States  patents
carry a presumption  of validity and generally can be  invalidated  only through
clear  and  convincing  evidence.  The  Company's  licensors  may  also  have to
participate  in  interference  proceedings  declared by the PTO to determine the
priority of an invention, which could result in substantial cost to the Company.
There can be no assurance  that the  Company's  licensed  patents  would be held
valid by a court or  administrative  body or that an alleged  infringer would be
found to be infringing.  The mere uncertainty resulting from the institution and
continuation of any technology-  related  litigation or interference  proceeding
could have  material  adverse  effect on the Company  pending  resolution of the
disputed matters.

The Company may also rely on  unpatented  trade secrets and know-how to maintain
its competitive position, which it seeks to protect, in part, by confidentiality
agreements  with employees,  consultants  and others.  There can be no assurance
that these agreements will not be breached or terminated,  that the Company will
have adequate  remedies for any breach, or that the Company's trade secrets will
not otherwise  become known or be independently  discovered by competitors.  See
"BUSINESS -- Patents."

DEPENDENCE ON AND NEED TO HIRE PERSONNEL

    The Company is highly  dependent  on its senior  management  and  scientific
staff,  which  currently  consists of Dr. Francis E. O'Donnell,  Jr.,  Chairman,
President  and Chief  Executive  Officer,  Mary  Anthony  Gray,  Executive  Vice
President and Chief Operating Officer,  and Dr. Charles E. McKenna. Dr. McKenna,
who  is the  inventor  of the  patents  licensed  to  the  Company  of the  core
technology  for Thiovir and who has  directed  the research on Thiovir at USC to
date, is a consultant  to the Company and only devotes a limited  portion of his
time to the Company's business.  The Company is highly dependent on the services
of Dr.  O'Donnell,  Ms.  Gray,  and Dr.  McKenna  and the  loss of any of  their
services would adversely  affect the Company.  Dr. O'Donnell is serving as Chief
Executive  Officer of the Company on an interim basis.  The Company is currently
seeking one or more additional executive officers.

    To develop and  commercialize  Thiovir,  the Company  must hire and retain a
number of additional highly qualified and experienced  management and scientific
personnel, consultants and advisors. The Company's ability to attract and retain
qualified  personnel  is  critical to the  Company's  success.  Competition  for
qualified  individuals  is  intense,  and the  Company  faces  competition  from
numerous  pharmaceutical  and  biotechnology  companies,  universities and other
research  institutions.  There can be no assurance that the Company will be able
to attract and retain such  individuals  on acceptable  terms or at all, and the
failure  to do so would  have a  material  adverse  effect on the  Company.  See
"MANAGEMENT -- Executive Officers and Directors."

BROAD DISCRETION IN USE OF PROCEEDS

    The net  proceeds of the  Offering  will be added to the  Company's  working
capital and will be available  for general  corporate  purposes,  including  the
Company's  drug  development  program.  As of the date of this  Prospectus,  the
Company cannot  specify with certainty the particular  uses for the net proceeds
to be added to its  working  capital.  Accordingly,  management  will have broad
discretion in the application of the net proceeds. See "USE OF PROCEEDS."

RISKS RELATED TO LICENSE AGREEMENT

    The agreement pursuant to which the Company has licensed the core technology
for Thiovir  permits the  Company's  licensor,  USC, to terminate  the agreement
under  certain  circumstances,  such as the  failure  by the  Company to use its
reasonable best efforts to commercialize  Thiovir or the occurrence of any other
uncured material breach by the Company.  The termination of this agreement would
have a material adverse effect on the Company.  The license  agreement  provides
that the licensor




                                       10




is primarily  responsible  for obtaining  patent  protection  for the technology
licensed to the  Company,  and the Company is required to  reimburse  it for the
costs it incurs in performing these activities.  The Company believes that these
costs as well as other costs under the license  agreement  will be  substantial,
and any  inability  or failure of the Company to pay these costs could result in
the termination of the license  agreement.  In addition,  the license  agreement
reserves  for the licensor the right to approve  sublicenses  granted  under the
license agreement.  Although such approval may not be unreasonably withheld, the
need for such  approval  may  inhibit the  Company's  development  of  strategic
relationships  necessary for the  commercialization of Thiovir. See "BUSINESS --
Research and Development Status and Activities" and -- "Relationship with USC."

LACK OF MANUFACTURING CAPABILITIES

    The Company does not have any manufacturing  capacity and currently plans to
seek  to  establish   relationships  with  third  party  manufacturers  for  the
manufacture of clinical trial material and the commercial production of Thiovir,
if any.  There can be no  assurance  that the Company  will be able to establish
relationships with third party manufacturers on commercially acceptable terms or
that  third  party  manufacturers  will  be  able to  manufacture  Thiovir  on a
cost-effective basis in commercial quantities under good manufacturing practices
("GMPs")  mandated by the FDA. The Company's  dependence  upon third parties for
the  manufacture  of its  products may  adversely  affect the  Company's  profit
margins  and its ability to develop  and  commercialize  Thiovir on a timely and
competitive  basis.  Further,  there can be no assurance that  manufacturing  or
quality  control  problems will not arise in connection  with the manufacture of
the  Company's  products  or  that  third  party  manufacturers  will be able to
maintain  the  necessary   governmental   licenses  and  approvals  to  continue
manufacturing  the Company's  products.  Any failure to establish  relationships
with third parties for its manufacturing requirements on commercially acceptable
terms would have a material  adverse  effect on the  Company.  See  "BUSINESS --
Manufacturing."

LACK OF SALES AND MARKETING CAPABILITIES

    The Company currently has no marketing or sales personnel.  The Company will
have  to  develop  a  sales  force  or  rely  on  marketing  partners  or  other
arrangements  with third  parties for the  marketing,  distribution  and sale of
Thiovir.  There can be no  assurance  that the Company will be able to establish
marketing,  distribution or sales  capabilities or make  arrangements with third
parties to perform those  activities on terms  satisfactory  to the Company,  or
that  any   internal   capabilities   or  third  party   arrangements   will  be
cost-effective.

    In addition, any third parties with which the Company establishes marketing,
distribution or sales  arrangements may have significant  control over important
aspects of the  commercialization of Thiovir,  including market  identification,
marketing  methods,   pricing,   composition  of  sales  force  and  promotional
activities.  There can be no assurance  that the Company will be able to control
the  amount  and  timing of  resources  that any third  party may  devote to the
Company's  products  or  prevent  any  third  party  from  pursuing  alternative
technologies  or products that could result in the  development of products that
compete with Thiovir and the withdrawal of support for Thiovir. See "BUSINESS --
Sales and Marketing."

DEPENDENCE ON THIRD PARTIES FOR DEVELOPMENT AND MANUFACTURING

    The Company intends to engage  independent  contract research  organizations
("CROs")  to conduct  clinical  trials in  connection  with the  development  of
Thiovir.  As a result,  this important aspect of the Company's  business will be
outside  the  direct  control  of the  Company.  In  addition,  there  can be no
assurance that the CROs will perform all of their obligations under arrangements
with the Company. See "BUSINESS -- Government Regulation."

NO ASSURANCE OF MARKET ACCEPTANCE

    The Company's success will depend in substantial part on the extent to which
Thiovir achieves market acceptance.  The degree of market acceptance will depend
upon a number  of  factors,  including  the  receipt  and  scope  of  regulatory
approvals,  the  establishment and demonstration in the medical community of the
safety and  effectiveness of Thiovir and its potential  advantages over existing
treatment  methods,  and




                                       11




reimbursement  policies of government  and third party  payors.  There can no be
assurance that physicians,  patients, payors or the medical community in general
will accept or utilize Thiovir.

UNCERTAINTY OF HEALTH CARE REFORM MEASURES AND THIRD PARTY REIMBURSEMENT

    The  business  and  financial  condition of  pharmaceutical  companies  will
continue to be affected by the efforts of governments  and third party payors to
contain  or  reduce  the cost of  health  care.  A  number  of  legislative  and
regulatory proposals aimed at changing the health care system have been proposed
in recent years.  In addition,  an emphasis on managed care in the United States
has  increased  and will  continue to increase  the  pressure on  pharmaceutical
pricing.  While the Company  cannot  predict  whether  legislative or regulatory
proposals will be adopted or the effect those  proposals or managed care efforts
may have on its business,  the announcement and/or adoption of such proposals or
efforts  could  have a material  adverse  effect on the  Company.  In the United
States and elsewhere,  sales of  prescription  pharmaceuticals  are dependent in
part on the  availability  of  reimbursement  to the  consumer  from third party
payors,   such  as  government   and  private   insurance   plans  that  mandate
predetermined  discounts from list prices.  Third party payors are  increasingly
challenging the prices charged for medical products and services. If the Company
succeeds in bringing  Thiovir to the market,  there can be no assurance  that it
will be considered cost effective or that  reimbursement to the consumer will be
available or will be  sufficient  to allow the Company to sell its products on a
competitive  basis. See "BUSINESS -- Health Care Reform Measures and Third Party
Reimbursement."

ABSENCE OF PRODUCT LIABILITY INSURANCE; INSURANCE RISKS

    The Company's  business will expose it to potential  product liability risks
that are inherent in the testing,  manufacturing and marketing of pharmaceutical
products.  There can be no assurance that product  liability  claims will not be
asserted  against the Company.  The Company does not currently  have any product
liability  insurance.  The Company intends to obtain limited  product  liability
insurance  for its clinical  trials when they begin in the United  States and to
expand  its  insurance  coverage  if  and  when  the  Company  begins  marketing
commercial products. However, there can no be assurance that the Company will be
able to obtain product liability  insurance on commercially  acceptable terms or
that the Company will be able to maintain such insurance at a reasonable cost or
in  sufficient  amounts to protect  the  Company  against  potential  losses.  A
successful  product  liability  claim or series of claims  brought  against  the
Company could have a material adverse effect on the Company.

HAZARDOUS MATERIALS

    In the event the Company  should  establish its own  laboratory  facility to
further its drug development  program,  such activities will necessarily involve
the use of hazardous materials, chemicals and viruses. Although the Company will
develop  procedures  for the handling and disposing of such  materials to comply
with the  standards  prescribed  by state and federal  regulations,  the risk of
accidental  contamination  or injury from these  materials  cannot be completely
eliminated.  In the event of such an accident,  the Company could be held liable
for any damages or fines that  result and any such  liability  could  exceed the
resources of the Company.

CONCENTRATION   OF  STOCK   OWNERSHIP;   CONTROL  OF  MANAGEMENT   AND  EXISTING
STOCKHOLDERS

    Upon  completion  of the Offering and appointing the issuance of the Pending
Shares, the Company's  directors,  executive  officers,  other key personnel and
their respective  affiliates will  beneficially own  approximately  30.3% of the
outstanding   Common   Stock   (approximately   29.1%   if   the   Underwriters'
over-allotment  option is exercised in full).  As a result,  these  stockholders
will be able to  exercise  significant  influence  over  all  matters  requiring
stockholder  approval,  including  the  election of  directors  and  approval of
significant  corporate  transactions.  Such  concentration of ownership may also
have the effect of  delaying  or  preventing  a change in control of the Company
that may be favored by other  stockholders.  See  "PRINCIPAL  STOCKHOLDERS"  and
"DESCRIPTION   OF  SECURITIES  --  Delaware  Law  and  Certain   Certificate  of
Incorporation and Bylaw Provisions."



                                       12




SUBSTANTIAL  SHARES OF COMMON  STOCK  RESERVED  FOR THE  EXERCISE OF OPTIONS AND
WARRANTS; OBLIGATIONS PURSUANT TO REGISTRATION RIGHTS

    The Company has reserved  500,000  shares of Common Stock for issuance  upon
the exercise of options  granted or available for grant to employees,  officers,
directors,  advisors and  consultants  pursuant to the Company's Stock Incentive
Plan (the  "Incentive  Plan"),  as well as an aggregate  of 1,900,000  shares of
Common Stock for issuance upon  exercise of the (i)  Redeemable  Warrants,  (ii)
Representative's  Warrants and (iii)  Outstanding  Warrants.  These  options and
warrants may adversely  affect the Company's  ability to obtain financing in the
future.  The holders of such  options and  warrants  can be expected to exercise
them at a time when the Company  would  otherwise  be able to obtain  additional
equity capital on terms more favorable to the Company.  See  "UNDERWRITING"  and
"CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS."

    The Company has agreed that, under certain  circumstances,  it will register
under federal and state  securities laws the  Representative's  Warrants and the
shares of Common  Stock  issuable  thereunder.  In addition,  certain  shares of
Common Stock previously issued by the Company are subject to registration rights
granted  by the  Company  in  connection  with  the  private  placement  of such
securities.  Exercise of these  registration  rights could  involve  substantial
expense to the Company at a time when it could not afford such  expenditures and
may  adversely  affect the terms upon which the  Company  may obtain  additional
financing. See "DESCRIPTION OF SECURITIES -- Common Stock."

POTENTIAL   ADVERSE   MARKET  IMPACT  OF  SHARES   ELIGIBLE  FOR  FUTURE  SALES;
REGISTRATION RIGHTS

    Sales of a substantial number of shares of Common Stock in the public market
following  the Offering  could  adversely  affect the market price of the Common
Stock. Holders of approximately  2,343,440 shares of Common Stock (including the
Pending  Shares and the shares  issuable  upon the  exercise of the  Outstanding
Warrants) are entitled to include,  subject to certain limitations,  such shares
in  certain  registration  statements  which  the  Company  may use to  register
additional shares of Common Stock. In addition,  approximately  2,643,440 shares
(including  the  Pending  Shares),  will be  eligible  for  resale,  subject  to
applicable  holding  periods,  in the public  market  under Rule 144 or Rule 701
under the Securities Act,  beginning 90 days after the date of this  Prospectus.
1,950,000 shares held by the directors,  officers and certain other stockholders
of the Company are subject to agreements  which restrict their sale for 12 or 13
months after the date of this  Prospectus  without the prior written  consent of
the   Representative.   See  "UNDERWRITING."  The  Company  intends  to  file  a
registration  statement under the Act to register 500,000 shares of Common Stock
reserved  for  issuance  under the  Incentive  Plan.  The  Company  is unable to
estimate  the number of shares which may actually be sold under Rule 144 or Rule
701 or pursuant to registration  rights,  since this will depend upon the market
price for the Common  Stock,  the  individual  circumstances  of the sellers and
other  factors.  Any such  sales may have an  adverse  effect  on the  Company's
ability to raise needed capital through an offering of its equity or convertible
debt  securities  and may adversely  affect the  prevailing  market price of the
Common Stock. See "DESCRIPTION OF SECURITIES -- Common Stock."

POTENTIAL ADVERSE EFFECT OF REDEMPTION OF REDEEMABLE WARRANTS

    The  Redeemable  Warrants  may be  redeemed by the Company at any time after
thirteen  months  from the date  hereof at a price of $.20 per  Warrant  upon 30
days' prior  written  notice,  provided  that the closing  trading  price of the
Common Stock for the 20 consecutive trading day period ending five days prior to
the giving of notice of redemption, equals or exceeds $9.00 per share. Notice of
redemption of the  Redeemable  Warrants  could force the holders to exercise the
Redeemable  Warrants at a time when it might be disadvantageous  for the holders
to do so or to sell the  Redeemable  Warrants at their then current market price
when  the  holders  might  otherwise  wish to hold  the  Warrants  for  possible
appreciation.  Alternatively, the holders may accept the redemption price, which
is  likely to be  substantially  less than the  market  value of the  Redeemable
Warrants  at the time of  redemption.  Any  holders  who do not  exercise  their
Redeemable  Warrants  prior to  their  redemption,  will  forfeit  the  right to
purchase the shares of Common Stock  underlying the Redeemable  Warrants.  While
the  Company may legally be  permitted  to give notice to redeem the  Redeemable
Warrants at a time when a current  prospectus is not available,  thereby leaving
the Redeemable  Warrant  holders no  opportunity  to exercise  their  Redeemable
Warrants  prior to  redemption,  the  Company  does not  intend  to  redeem  the
Redeemable  Warrants  unless a current  prospectus  is  available at the time of
redemption. See "DESCRIPTION OF SECURITIES -- Redeemable Warrants."



                                       13



REPRESENTATIVE'S WARRANTS

    In   connection   with  this   Offering,   the  Company  will  sell  to  the
Representative for a nominal amount the Repressentative  Warrants to purchase up
to  100,000  shares  of  Common  Stock  and  100,000  Redeemable  Warrants.  The
Representative's  Warrants  will be  exercisable  commencing  one year  from the
effective date of this Prospectus and will continue to be exercisable until five
years from the date  hereof at an  exercise  price  equaling  160% of the public
offering  price of the Common Stock and the Redeemable  Warrants,  respectively.
During the term of the  Representative's  Warrants,  the holders thereof will be
given the  opportunity  to profit from a rise in the market  price of the Common
Stock or Redeemable  Warrants  with a resulting  dilution in the interest of the
Company's  other  stockholders.  The terms on which  the  Company  could  obtain
additional  capital  during  the life of the  Representative's  Warrants  may be
adversely affected because the holders of the Representative's Warrants might be
expected  to  exercise  them if the  Company  were  able to  obtain  any  needed
additional  capital in a new offering of  securities at a price greater than the
exercise price of the Representative's  Warrants. See "DESCRIPTION OF SECURITIES
- -- Representative's Warrants."

NO PRIOR MARKET FOR COMMON STOCK AND THE REDEEMABLE WARRANTS

    Prior to the Offering,  there has been no public market for the Common Stock
or the Redeemable Warrants, and there can be no assurance that an active trading
market will develop or be sustained after the Offering or that investors will be
able to sell the Common Stock or the Redeemable  Warrants  should they desire to
do so. The initial public offering price was determined by negotiations  between
the Company and the  Representative and may bear no relationship to the price at
which the Common Stock or the Redeemable  Warrants will trade upon completion of
the Offering. See "UNDERWRITING."

VOLATILITY OF STOCK PRICE

    The market price of the Common Stock and the  Redeemable  Warrants is likely
to be highly  volatile and could be subject to wide  fluctuations in response to
factors  concerning the Company or its competitors  such as announcements of the
results of clinical trials,  developments with respect to patents or proprietary
rights,   announcements  of  technological  innovations,  new  products  or  new
contracts, actual or anticipated variations in operating results due to a number
of factors including,  among others, the level of development expenses,  changes
in financial  estimates by  securities  analysts,  conditions  and trends in the
pharmaceutical  and  other  industries,  adoption  of new  accounting  standards
affecting  the  industry,  general  market  conditions  and other  factors.  The
Company's  operating  results  may  also be below  the  expectations  of  market
analysts and investors, which would likely have a material adverse effect on the
prevailing market price of the Common Stock or the Redeemable Warrants.

    Further,   the  stock  market  has  experienced  extreme  price  and  volume
fluctuations  that  have  particularly  affected  the  market  prices  of equity
securities of many pharmaceutical companies. These price fluctuations often have
been  unrelated  or  disproportionate  to  the  operating  performance  of  such
companies.  Market  fluctuations,  as well as general  economic,  political  and
market  conditions such  as recessions or international  currency  fluctuations,
may  adversely  affect the market  price of the Common  Stock or the  Redeemable
Warrants.  In the past,  following  periods of volatility in the market price of
the securities of companies in the  pharmaceutical  industry,  securities  class
action  litigation  has often been  instituted  against  those  companies.  Such
litigation, if instituted against the Company, could result in substantial costs
and a  diversion  of  management  attention  and  resources,  which would have a
material  adverse  effect on the Company.  The  realization  of any of the risks
described in these "RISK  FACTORS"  could have a dramatic and adverse  impact on
the market price of the Common Stock or the Redeemable Warrants.

IMMEDIATE AND SUBSTANTIAL DILUTION

Purchasers  of the Common  Stock in the  Offerings  will  suffer  immediate  and
substantial  dilution of $3.82 per share in the net  tangible  book value of the
Common  Stock  from the  initial  public  offering  price.  To the  extent  that
outstanding  options and  warrants to purchase  the  Company's  Common Stock are
exercised, there will be further dilution. See "DILUTION."



                                       14



NO DIVIDENDS

    The Company has never  declared  or paid any cash  dividends  on its capital
stock.  The Company  currently  does not intend to pay any cash dividends in the
foreseeable future and intends to retain its earnings, if any, for the operation
of its business. See "DIVIDEND POLICY."

ANTI-TAKEOVER EFFECTS OF CERTIFICATE OF INCORPORATION, BYLAWS AND DELAWARE LAW

    The Company's Certificate of Incorporation authorizes the Company's Board of
Directors (the "Board") to issue shares of undesignated  preferred stock without
stockholder approval on such terms as the Board may determine. The rights of the
holders of Common  Stock will be subject to, and may be  adversely  affected by,
the rights of the holders of any such preferred  stock that may be issued in the
future. Moreover, the issuance of preferred stock may make it more difficult for
a third party to acquire,  or may  discourage  a third party from  acquiring,  a
majority of the voting stock of the Company.  The Company's  Board is classified
into three classes of directors. With a classified Board, one class of directors
is elected each year with each class serving a three-year  term. These and other
provisions  of the  Certificate  of  Incorporation  and the  Bylaws,  as well as
certain  provisions  of  Delaware  law,  could  delay or impede  the  removal of
incumbent  directors  and could make more  difficult a merger,  tender  offer or
proxy contest involving the Company,  even if such events could be beneficial to
the interest of the  stockholders.  Such  provisions  could limit the price that
certain  investors  might be willing to pay in the future for the Common  Stock.
See  "DESCRIPTION  OF  SECURITIES  -- Delaware  Law and Certain  Certificate  of
Incorporation and Bylaw Provisions."

LIMITATION ON OFFICERS' AND DIRECTORS' LIABILITIES UNDER DELAWARE LAW

    Pursuant to the Company's Certificate of Incorporation,  as authorized under
applicable  Delaware  law,  directors of the Company are not liable for monetary
damages for breach of fiduciary duty,  except in connection with a breach of the
duty of  loyalty,  for acts or  omissions  not in good  faith  or which  involve
intentional  misconduct or a knowing  violation of law, for dividend payments or
stock  repurchases  illegal under Delaware law or for any transaction in which a
director has derived an improper  personal benefit.  In addition,  the Company's
Certificate  of  Incorporation  provides  that the Company  must  indemnify  its
officers and directors to the fullest  extent  permitted by Delaware law for all
expenses  incurred in the  settlement  of any actions  against  such  persons in
connection with their having served as officers or directors of the Company. See
"DESCRIPTION   OF  SECURITIES  --  Delaware  Law  and  Certain   Certificate  of
Incorporation and Bylaw Provisions."

MAINTENANCE REQUIREMENTS FOR NASDAQ SMALLCAP SECURITIES

    It is anticipated that the Common Stock and the Redeemable  Warrants will be
approved for listing on the Nasdaq SmallCap Market.  An issuer seeking continued
inclusion of its  securities on the SmallCap  Market is required to meet certain
criteria  including  (i) total assets of at least  $2,000,000;  (ii) capital and
surplus of at least $1,000,000; and (iii) a minimum bid price of $1.00 per share
unless the market value of its public float is at least $1,000,000 and it has at
least $2,000,000 in capital and surplus.  Upon completion of this Offering,  the
Company anticipates that it will satisfy the criteria for continued inclusion of
its securities on the Nasdaq SmallCap Market. However, there can be no assurance
that the Company will  continue to satisfy such  criteria and for how long.  See
"PROSPECTUS SUMMARY -- Summary Financial  Information" and  "CAPITALIZATION." If
the  Company  became  unable to meet the  continued  quotation  criteria  of the
SmallCap Market and was suspended  therefrom,  the Company's securities could be
subject to a rule that imposes additional sales practice requirements on certain
broker/dealers  who sell such  securities  to  persons  other  than  established
customers and accredited investors.  Consequently, an investor would likely find
it more  difficult  to dispose of, or to obtain  accurate  quotations  as to the
value of, the Company's securities.

REQUIRED DISCLOSURE CONCERNING TRADING OF PENNY STOCKS OR LOW-PRICED SECURITIES

    The  Securities  and  Exchange  Commission  (the  "Commission")  has adopted
regulations  that define a "penny  stock" to be any equity  security  that has a
market  price (as  defined  therein)  of less than $5.00 per  share,  subject to
certain exceptions.  For any transaction involving a penny stock, unless exempt,



                                       15




the rules  require  the  delivery,  prior to the  transaction,  of a  disclosure
schedule  prepared by the  Commission  relating to the penny stock  market.  The
broker-dealer   also  must  disclose  the   commissions   payable  to  both  the
broker-dealer  and the  registered  representative,  current  quotations for the
securities  and,  if the  broker-dealer  is the sole  market-maker  of the penny
stock,  the  broker-dealer  must  disclose  this  fact  and the  broker-dealer's
presumed  control  over the market.  Finally,  monthly  statements  must be sent
disclosing  recent price information for the penny stock held in the account and
information on the limited market in penny stocks.

    While many securities  listed on the Nasdaq SmallCap Market would be covered
by the  definition  of penny  stock,  transactions  in such a security  would be
exempt  from all but the sole  market-maker  provision  for (i) issuers who have
$2,000,000  in  tangible  assets  ($5,000,000  if the  issuer  has  not  been in
continuous  operation for three years),  (ii) transactions in which the customer
is an institutional  accredited  investor,  and (iii)  transactions that are not
recommended  by the  broker-dealer.  In  addition,  transactions  in a  SmallCap
security  directly  with a  Nasdaq  market-maker  for such  securities  would be
subject  only to the  sole  market-maker  disclosure,  and the  disclosure  with
respect  to  commissions  to be paid  to the  broker-dealer  and the  registered
representative.  Finally,  all SmallCap securities would be exempt if The Nasdaq
Stock  Market,  Inc.,  the operator of the Nasdaq  SmallCap  Market,  raised its
requirements for continued  listing so that any issuer with less than $2,000,000
in net tangible  assets or  stockholders'  equity would be subject to delisting.
These  criteria are more stringent  than the current  maintenance  requirements.
Consequently, these rules may restrict the ability of broker-dealers to sell the
Company's  securities  and may affect  the  ability  of  purchasers  to sell the
Company's securities in the secondary market.

             SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

    Statements  herein  regarding the time period during which the proceeds from
the  Offering  will  fund the  Company's  operations  and the dates on which the
Company   anticipates   commencing  clinical  trials  with  respect  to  Thiovir
constitute  forward-looking  statements under the federal  securities laws. Such
statements are subject to certain risks and  uncertainties  that could cause the
rate at which the  Company  incurs  expenses  and the actual  timing of clinical
trials to differ  materially from those  projected.  With respect to such dates,
the Company's  management  team has made certain  assumptions  regarding,  among
other things,  the successful and timely  completion of preclinical  tests,  the
approval  of an  Investigational  New Drug  Exemption  Application  ("IND")  for
Thiovir by the FDA, the availability of adequate clinical supplies,  the absence
of delays in patient  enrollment,  the  availability  of the  capital  resources
necessary to complete the preclinical tests and conduct the clinical trials, the
nature,  scope, and number of the preclinical tests and clinical trials required
for FDA  approval  and the  cost of  completing  these  tests  and  trials.  The
Company's  ability to proceed with its drug  development  program in  accordance
with the dates  anticipated is subject to certain risks,  as discussed under the
caption "RISK FACTORS"  contained herein,  and the Company's ability to estimate
the time period for which the proceeds of the Offering  will fund the  Company's
operations is subject to  substantial  uncertainty  due to the factors  outlined
under the caption "USE OF PROCEEDS" contained herein.  Undue reliance should not
be placed on the dates and time periods referenced  herein.  These estimates are
based on the current  expectations of the Company's  management  team, which may
change in the  future  due to a large  number  of  potential  events,  including
unanticipated future developments.



                                       16



                                 USE OF PROCEEDS

    The net  proceeds to the  Company  from the sale of the  Securities  offered
hereby are estimated to be approximately $4,140,000 (approximately $4,805,550 if
the Underwriters'  over-allotment  option is exercised in full), after deducting
$510,000 for underwriting discounts (approximately $586,500 if the Underwriters'
over-allotment option is exercised in full) and approximately $450,000 for other
estimated  offering  expenses   (approximately  $472,950  if  the  Underwriters'
over-allotment  option is exercised  in full),  including  the  Representative's
non-accountable  expense  allowance  and  the  consulting  fee  payable  to  the
Representative,  and  assuming no exercise of the  Redeemable  Warrants  offered
hereby.

    The Company intends to use the net proceeds from the Offering, including any
interest thereon, to finance research and development activities with respect to
Thiovir, primarily for preclinical tests and clinical trials designed to satisfy
FDA standards for safety and efficacy,  and to provide working  capital.  Due to
the nature of the drug development and approval  process,  the Company is unable
to  accurately  indicate the exact  amount of proceeds  allocable to each of the
Company's  activities.  The amounts actually expended for each activity may vary
significantly  depending  upon  numerous  factors,  including  the  progress  of
development  activities,  the scope  and  results  of  preclinical  testing  and
clinical  trials,  the cost,  timing and outcome of regulatory  agency  reviews,
administrative  and legal expenses,  costs of developing a patent position,  the
acquisition  of  technology  that may  enhance  and/or  be  compatible  with the
Company's then existing  technology,  the  establishment of  relationships  with
consultants  and with third  parties for  manufacturing  and sales and marketing
functions, and on other factors.

    Notwithstanding  the foregoing,  however,  the information below constitutes
the  Company's  best estimate as to the use of the proceeds  generated  from the
Offering:

<TABLE>
<CAPTION>
                                    ACTIVITY                                            % OF PROCEEDS
                                    --------                                            -------------
  <S>                                                                                        <C>
  Testing and Clinical Trials                                                                 50
  CROs and Consultants                                                                        20
  General Working Capital                                                                     30
</TABLE>

    Any  net  proceeds   received   from  the  exercise  of  the   Underwriters'
over-allotment option will be used to supplement general working capital.

    The Company  believes  that the  estimated  net  proceeds  of the  Offering,
together with its existing cash and short-term investments,  will be adequate to
satisfy its anticipated capital requirements at least through December 31, 1998.
See "RISK FACTORS -- Future  Capital Needs;  Uncertainty of Additional  Funding"
and "SPECIAL NOTE REGARDING FORWARD-LOOKING  STATEMENTS." Pending such uses, the
Company intends to invest  proceeds  primarily in short-term,  investment  grade
obligations.

                                 DIVIDEND POLICY

    The Company has not declared or paid any dividends on its capital stock. The
Company  currently  intends to retain all future  earnings,  if any,  to finance
growth  and  development  of its  business  and,  therefore,  does not expect to
declare or pay any cash dividends in the foreseeable  future. The declaration of
dividends is within the discretion of the Company's  Board. See "RISK FACTORS --
No Dividends."




                                       17



                                    DILUTION

    At  November  30,  1996,  the net  tangible  book value of the  Company  was
$473,903,  or approximately  $.18 per share. "Net tangible book value" per share
of Common Stock  represents the amount of the Company's  total tangible  assets,
less the  amount of its total  liabilities,  divided  by the number of shares of
Common Stock outstanding.  Dilution represents the difference between the amount
per share of Common Stock paid by the new  investors  purchasing in the Offering
and the pro forma net  tangible  book value per share of Common  Stock after the
Offering. After giving effect to the sale by the Company of the 1,000,000 shares
of Common  Stock  offered  hereby at  $5.10(1)  per share and the payment of the
estimated  expenses  related to the Offering of $450,000 but giving no effect to
the issuance of the Pending Shares, the pro forma net tangible book value of the
Company at November 30, 1996 would have been  $4,613,903,  or $1.28 per share of
Common Stock.  This represents an immediate  increase in net tangible book value
of $1.10 per share of Common  Stock to existing  stockholders  and an  immediate
dilution of $3.82 per share of Common Stock to new investors  purchasing  Common
Stock in the Offering, as illustrated in the following table:
<TABLE>
<CAPTION>
<S>                                                                    <C>      <C>
Price per share in the Offering(1)                                              $ 5.10

   Net tangible book value per share before the Offering                .18
   Increase per share attributable to new investors                    1.10
                                                                     ------
Pro forma net tangible book value per share after the Offering                    1.28
                                                                                ------
Dilution to new investors                                                       $ 3.82
                                                                                ======
</TABLE>



(1) Includes the purchase price of $.10 per Redeemable Warrant.



    In the event that the  Underwriters  exercise the  over-allotment  option in
full,  the pro forma net tangible book value per share of Common Stock after the
Offering (less underwriting  commissions and discounts and estimated expenses of
the Offering) would be approximately $1.41 per share,  representing an immediate
increase in net tangible book value of approximately  $1.23 per share to current
stockholders and an immediate  dilution of approximately  $3.69 per share to new
investors.

    The  following  table sets  forth (i) the  number of shares of Common  Stock
purchased  from the  Company by the  existing  stockholders,  and  assuming  the
issuance of the Pending  Shares,  the total  consideration  paid and the average
price per share paid for such shares by the existing stockholders;  and (ii) the
number of shares of Common Stock to be sold by the Company in the Offering,  the
total  consideration  to be paid  and  the  average  price  per  share:  <TABLE>
<CAPTION>
                                               SHARES PURCHASED          TOTAL CONSIDERATION
                                               ----------------          -------------------
                                                                                                   AVERAGE PRICE
                                              NUMBER    PERCENTAGE       AMOUNT       PERCENTAGE     PER SHARE
                                              ------    ----------       ------       ----------     ---------
<S>                                         <C>         <C>          <C>              <C>          <C>
New Investors                               1,000,000       27.4%    $5,000,000(2)       80.5%      $    5.00
Existing Stockholders                       2,643,440       72.6%    $1,210,654          19.5%      $    0.46(3)(4)
                                            ---------      -----     ----------         -----
Total                                       3,643,440      100.0%    $6,210,654         100.0%
                                            =========      =====     ==========         =====




(2)  Prior to the deduction of expenses relating to the Offering.

(3)  Excludes  $1,519,050,  representing the excess of the fair value of 950,000
     shares  issued (in August  1996) over cash  received  of $950,  recorded as
     research  and  development  expense.  See Note 5 of Notes to the  Financial
     Statements hereto.

(4)  Includes 1,950,000 shares of Common Stock previously sold for an average of
     $.05 per share,  643,440 shares of Common Stock  previously  sold for $1.60
     per  share,  and the  issuance  of the 50,000  Pending  Shares at $1.60 per
     share.
</TABLE>

     The foregoing  table excludes  shares of Common Stock issuable  pursuant to
the  exercise  of  the  Outstanding  Warrants,   none  of  which  are  currently
exercisable.  As of February 5, 1997,  warrants  to  purchase  an  aggregate  of
700,000 shares of Common Stock at a price of $10.00 per share were  outstanding.
None of these warrants are currently exercisable. The table also excludes shares
of Common Stock  issuable upon the exercise of up to 500,000 stock options which
may be issued under the Company's  Incentive  Plan. As of February 5, 1997,  the
Company had issued  options to purchase an aggregate of 10,000  shares of Common
Stock pursuant to the Incentive  Plan and had made  commitments to three outside
directors to issue  options to purchase an aggregate of 30,000  shares of Common
Stock at exercise  prices to be determined,  but in any case not less than $5.00
per share.


                                       18




                                 CAPITALIZATION

    The following table sets forth the actual  capitalization  of the Company at
November 30, 1996, and the  capitalization of the Company as adjusted to reflect
the sale by the Company of the Securities  offered hereby and the Pending Shares
and the initial  application  of the  estimated  proceeds  thereof.  See "USE OF
PROCEEDS." This table should be read in conjunction with the Company's Financial
Statements and the Notes thereto included elsewhere herein.


                                                            NOVEMBER 30, 1996   
                                                            -----------------   
                                                         ACTUAL      AS ADJUSTED
                                                         ------      -----------
Stockholders' equity:                                    
                                                         
    Preferred stock -- $0.01 par value;  1,000,000                              
      shares authorized, actual and as adjusted --                              
      0 shares issued and outstanding                  $      --     $       -- 
                                                        
    Common  Stock -- $0.01 par  value;  25,000,000                              
      shares authorized,  actual shares issued and                              
      outstanding   2,593,440   and  as   adjusted                              
      3,643,440                                            25,934        36,434 
                                                                                
    Additional paid-in capital                          2,609,739     6,784,743 
                                                                                
    Deficit during the development stage               (2,090,690)   (2,090,690)
                                                                                
    Subscription receivable                               (34,496)           -- 
                                                       ----------    ---------- 
          Total stockholders' equity                      510,487     4,730,487 
                                                       ----------    ---------- 
Total capitalization                                  $   510,487    $4,730,487 
                                                       ==========    ==========

                          SELECTED FINANCIAL DATA

    The  following  selected  financial  data of the  Company  as of and for the
period ended  November 30, 1996 is derived from the  financial  statements  that
have been audited by McGladrey & Pullen, LLP, independent  auditors.  These data
should be read in conjunction  with the Company's  Financial  Statements and the
Notes thereto included elsewhere in this Prospectus and Management's  Discussion
and Analysis of Financial Condition and Results of Operations which follow.

STATEMENT OF ACTIVITIES DATA:


                                                        PERIOD FROM JULY 5,1996,
                                                         DATE OF INCEPTION, TO
                                                           NOVEMBER 30, 1996
                                                         ---------------------
 Revenue:
    Interest income                                          $     1,858
 Costs and Expense:
    Research and development                                   2,058,980
    General and administrative                                    33,568
                                                               2,092,548
 Net loss                                                     (2,090,690)
 Net loss per common share(1)                               $      (.81)
 Shares used in computing net loss per common share(1)         2,593,440

BALANCE SHEET DATA:


                                                           NOVEMBER 30, 1996
                                                         ---------------------
 
Cash and cash equivalents                                   $    495,421
 Working capital                                                 503,621
 Total assets                                                    532,005
 Deficit accumulated during the development stage             (2,090,690)
 Total stockholders' equity                                      510,487

- ---------
(1) See  notes  1  and  4 of  Notes  to  Financial  Statements  for  information
    concerning  the  computation of net loss per common share and shares used in
    computing net loss per common share.

(2) As  adjusted  to  reflect  the sale of the Common  Stock and the  Redeemable
    Warrants  offered  hereby and the  application of the estimated net proceeds
    therefrom. See "USE OF PROCEEDS."




                                       20




                  MANAGEMENT'S DISCUSSION AND ANALYSIS OF
               FINANCIAL CONDITION AND RESULTS OF OPERATIONS

    The following should be read in conjunction  with "SELECTED  FINANCIAL DATA"
and the Company's Financial  Statements and Notes thereto appearing elsewhere in
this Prospectus.

OVERVIEW

    The Company is a development  stage  pharmaceutical  company  engaged in the
development of a single new antiviral drug candidate called Thiovir. The Company
was incorporated in 1988 but remained a "shell" corporation, i.e. without assets
or liabilities,  until July 1996, when it commenced the acquisition of a license
of certain proprietary rights to, and the development of, Thiovir.

    The Company is a  development  stage  company,  has not derived any revenues
from the sale of products and has relied upon private  equity  financing for its
capital.  As of  November  30,  1996,  the  Company's  accumulated  deficit  was
$2,090,690.

    The Company has no operating history upon which an evaluation of the Company
and its prospects can be based. The risks, expenses and difficulties encountered
by companies at an early stage of development must be considered when evaluating
the  Company's  prospects.  There are numerous  risks  inherent in a development
stage company which is reliant upon the  development of a single  pharmaceutical
product,  including the uncertainties of research and the outcome of preclinical
testing  and  clinical  trials,  a lengthy  and  expensive  regulatory  approval
process,  obtaining and defending a satisfactory patent position, and attracting
and retaining motivated and qualified personnel. See "RISK FACTORS."

    The operating expenses of the Company cannot be predicted with certainty and
will  depend  on  several  factors,  primarily  the  level  of drug  development
expenses.  Development  expenses  will depend on the progress and results of the
Company's  development,  preclinical tests and clinical trials of Thiovir, which
cannot be predicted. Management may be able to control the timing of development
expenses  in  part by  accelerating  or  decelerating  preclinical  testing  and
clinical  trial  activities,  although  attainment  of  the  Company's  business
objectives may necessitate pursuit of these activities on an accelerated basis.

RESULTS OF ACTIVITIES

  PERIOD FROM JULY 5, 1996, DATE OF INCEPTION, TO NOVEMBER 30, 1996

    The Company had interest  income of $1,858 in the period ended  November 30,
1996.

    In August 1996, the Company paid $100,000 in cash and issued, for total cash
consideration  of $200,  200,000  shares of its  Common  Stock and  warrants  to
purchase an additional  200,000 shares of Common Stock, in  consideration of the
grant to the Company of an option to acquire a license of certain  rights to the
drug Thiovir.  Also in August 1996,  the Company  issued an  additional  750,000
shares  of  Common  Stock  for cash  consideration  of $750 to  certain  persons
instrumental in the development of Thiovir and the Company's  acquisition of the
option to acquire the license of certain rights to Thiovir. Management estimated
the  fair  value  of the  950,000  shares  at  $1.60  per  share  for a total of
$1,520,000,  based upon the offering  price of the  Company's  Common Stock in a
private placement  offering commenced on August 20, 1996. In September 1996, the
Company  exercised  its option to acquire  the  license of rights to Thiovir and
paid an additional $440,000 in cash therefor. The Company charged the difference
between the estimated  aggregate  value and the aggregate cash purchase price of
the  950,000  shares,  or  $1,519,050,   and  the  cash  consideration  paid  of
approximately  $540,000 for the licensing  rights,  as research and  development
expense. See "CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS."

    General and administrative expenses totaled $33,568, primarily consisting of
compensation, travel and office expense.

    The Company  incurred a net loss of $2,090,690 for the period ended November
30, 1996.  With the completion of the Offering,  the Company  expects to incur a
significant  increase in the level of research and  development  and general and
administrative   expenses,  which  will  result  in  a  significantly  increased
accumulated deficit.




                                       21




PERIOD FROM INCORPORATION TO JULY 5, 1996, DATE OF INCEPTION

    For the period from  incorporation  (1988)  through  November 30, 1995,  the
Company was inactive, had no capital funds, received no revenues and incurred no
expenses.

LIQUIDITY AND CAPITAL RESOURCES

    The Company has financed its  activities  since July 5, 1996  primarily from
the net proceeds of private placements of Common Stock. As of November 30, 1996,
the Company had received  aggregate cash proceeds of  $1,130,654.  In July 1996,
three stockholders of the Company  contributed a total of $100,200 to the equity
capital of the Company.  In October 1996, the Company paid cash of $539,930 and,
in August  1996,  issued  shares of its Common  Stock with a value,  net of cash
consideration  received  for the shares,  of  $1,519,050  in  consideration  for
license of certain rights to Thiovir.  In October 1996, the Company  completed a
private  placement  of  665,000  shares at $1.60 per share for net  proceeds  of
$1,015,473,  of which  $34,496 was  receivable at November 30, 1996. At November
30, 1996, the Company's  liquidity  consisted of total cash and cash equivalents
of $495,421.

    The  Company   expects   that  its  capital   requirements   will   increase
substantially  in future  periods  as the  Company  funds  its drug  development
program.  The Company's future capital requirements will depend on many factors,
including the progress of the Company's drug development  program, the scope and
results of preclinical testing and clinical trials, the cost, timing and outcome
of regulatory  reviews,  costs of patent  prosecution,  administrative and legal
expenses,  the establishment of capacity for sales and marketing functions,  the
establishment of relationships  with third parties for  manufacturing  and sales
and marketing functions, and other factors.

    The Company believes that the net proceeds of the Offering together with its
existing  cash and  short-term  investments  will be  adequate  to  satisfy  its
anticipated capital requirements through at least December 31, 1998. The Company
expects that it may be required to raise  substantial  additional  funds through
equity or debt financings, collaborative arrangements with corporate partners or
from other sources.  There can be no assurance that  additional  funding will be
available  on  favorable  terms from any of these  sources or at all.  See "RISK
FACTORS -- Future Capital Needs; Uncertainty of Additional Funding" and "SPECIAL
NOTE REGARDING FORWARD-LOOKING STATEMENTS."

    For a discussion of the Company's plan of operation, see "USE OF PROCEEDS."



                                       22




                                    BUSINESS

    OVERVIEW

    The Company is a development  stage  pharmaceutical  company  engaged in the
development of  thiophosphonoformic  acid ("TPFA"), an anti-viral compound,  for
which the Company has adopted the trade name "Thiovir(tm)." The initial focus of
the  Company's  development  activities  will be to  demonstrate  the safety and
efficacy of Thiovir for  treatment  of patients  infected  with HIV and patients
showing active  infection of CMV, which causes  blindness and other  conditions.
CMV is primarily  manifested  among AIDS  patients.  The Company  believes  that
Thiovir,  if successfully  developed and approved for sale,  would  constitute a
candidate for inclusion in combination  drug therapy for HIV/AIDS  treatment and
would provide several  benefits over existing  treatments for CMV,  particularly
its potential  ability to replace more toxic  intravenous  treatment with a less
toxic  oral  treatment.  The only  development  work on Thiovir to date has been
limited  laboratory and animal studies conducted by unaffiliated  organizations.
Therefore, Thiovir is in an early stage of development.

    In the  United  States,  the use and sale of Thiovir is subject to the rules
and  regulations  of the FDA, and  obtaining  the  necessary  FDA approval  will
require  substantial  preclinical tests and clinical trials. The Company expects
to commence  clinical  trials for Thiovir in 1997.  The  Company  believes  that
Thiovir may meet the criteria  established by the FDA for accelerated  approval.
As a result, the Company may be able to commercialize  Thiovir in a shorter time
period than has  historically  been applicable for a drug that does not meet the
criteria for accelerated approval. See "BUSINESS -- Government Regulation."

    Initially,   the   Company   intends  to   maintain   a  limited   corporate
infrastructure    devoted   almost    exclusively   to   the   development   and
commercialization  of  Thiovir.  Accordingly,  the  Company  will engage CROs to
conduct preclinical tests and clinical trials on Thiovir.  The Company will also
contract with other  companies to manufacture  the drug. The Company  intends to
rely upon  part-time  consultants  and CROs to provide  expertise  in  designing
appropriate  tests and trials and in seeking FDA and other government  approval.
Furthermore,  the Company  does not believe that it will be necessary to develop
an  extensive  sales and  marketing  force to promote the sale of Thiovir in the
United States, if and when it may be sold, since the market for HIV/AIDS and CMV
therapies is concentrated among a relatively small number of care providers.

    In August  1996,  the Company  acquired an  exclusive  worldwide  license to
proprietary  rights to Thiovir  held by the  University  of Southern  California
("USC") from a limited  partnership which funded the research and development of
Thiovir. The Company had generated no revenues from the sale of products and, as
of November 30, 1996, has an accumulated  deficit of $2,090,690. There can be no
assurance that the Company will ever achieve profitable operations.

    The Company's executive offices are located at 10940 Wilshire Boulevard, Los
Angeles,  California,  pursuant to a short-term  lease.  The Company  expects to
relocate its offices, most likely in the Southern California region, as it hires
additional employees to staff increased operational  activity.  The Company is a
Delaware  corporation  and is the successor by merger to a Missouri  corporation
which was originally formed in 1988, but remained a "shell"  corporation with no
operations,  assets or  liabilities  until its  acquisition of license rights to
TPFA.

TARGETED INDICATIONS FOR THIOVIR

    HIV/AIDS.  AIDS occurs when, through viral  replication,  the amount of HIV,
i.e. the HIV "viral load," reaches  sufficiently  high levels.  The treatment of
AIDS has increasingly focused on inhibiting two enzymes, known as "protease" and
"reverse  transcriptase"  ("RT"),  the  activity of which are  necessary  to the
process of HIV  replication.  Initially,  AIDS was treated  with  nucleoside  RT
inhibitors,  such as AZT. Prior to the introduction of protease  inhibitors,  RT
inhibitors  offered only  short-term  clinical  benefit,  were often toxic,  and
constituted a costly treatment regimen relative to the derived benefit. Protease
inhibitors



                                       23




have generally not been effective when used alone. However, significant clinical
benefit has been achieved by the use of protease  inhibitor drugs in combination
with one or more RT inhibitor drugs,  resulting in a dramatically  reduced viral
load.

    The long-term  efficacy of the drugs now being used to reduce HIV viral load
is an  unresolved  issue.  Resistance  to  one  or  more  drugs  being  used  in
combination drug therapy has been  increasingly  recognized in some patients due
to HIV's ability to mutate.  Patient  compliance  has also been  recognized as a
problem with combination  drug therapy because the treatment  regimen is complex
and demanding and often results in serious, unwanted side effects.  According to
published reports, the recently-introduced  combination drug therapies have been
least effective among patients who had previously been subjected to a regimen of
AZT or other nucleoside RT inhibitors.  Consequently,  the search for new drugs,
and for new combinations of drugs for the treatment of HIV/AIDS, continues at an
intense level of activity.

    Thiovir is a non-nucleoside  RT inhibitor that has inhibited the replication
of HIV in laboratory tests. As a result of such tests, the Company believes that
the potential exists for Thiovir to be an attractive  candidate for inclusion in
combination drug therapy for HIV/AIDS for the following reasons:

    * The resistance to combination drug therapies  exhibited among patients who
      had previously undergone therapy with a nucleoside RT inhibitor may not be
      exhibited   when  the   nucleoside   RT  inhibitor  is  replaced   with  a
      non-nucleoside RT inhibitor.

    * If  Thiovir  were to  prove  effective  in treating both HIV/AIDS and CMV,
      physicians  may  include  Thiovir in a  combination  drug  therapy for its
      double effect of treating HIV/AIDS and, on a prophylactic basis, CMV.

    * Laboratory  studies to date  suggest that Thiovir may result in fewer side
      effects  and,  due to its oral  availability,  may  decrease the number of
      pills required to be taken in combination  drug therapy.  Combination drug
      therapies  typically  involve  numerous  pills  taken  at  least  two  and
      frequently  more times a day.  Drugs having fewer adverse side effects and
      requiring  fewer dosages  generally lead to  significantly  better patient
      compliance.

CMV. CMV is a virus which resides in most human beings.  It is an  opportunistic
virus  that may  become  active  when  the  human  immune  system  is  weakened.
Consequently,  AIDS patients are at  considerable  risk of active CMV infection.
The  primary  manifestation  of active CMV  infection,  estimated  at 85% of all
manifestations,  is in  the  retina  of  the  eye  (CMV  retinitis).  Other  CMV
manifestations include  gastrointestinal  infection (symptoms include ulcers and
chronic   diarrhea)   and   neurologic   infection   (encephalitis   and   other
complications).  If  untreated,  CMV  retinitis  completely  destroys the retina
causing  blindness.  Treatment  controls but does not eliminate  CMV, so ongoing
therapy is generally necessary.

    Until recently,  physicians  typically treated CMV retinitis with two drugs,
foscarnet  and  ganciclovir.  In June  1996,  the  FDA  approved  a third  drug,
cidofovir, for treatment of CMV retinitis. The Company is aware of several other
drugs which are under development for the treatment of CMV retinitis.  Foscarnet
is  administered  on a daily  basis by means of a  surgically-implanted  central
intravenous line due to its low bio-availability, which precludes administration
orally.  Central  intravenous drug therapy is substantially  more burdensome and
costly  than  oral  drug  therapy.  Ganciclovir  is  available  in both oral and
intravenous forms. Oral administration, however, is typically only used after an
induction  period  of  central  intravenous  administration.  CMV has  developed
resistance  to  ganciclovir  in some  patients.  In  addition,  ganciclovir  has
exhibited bone marrow toxicity in some cases,  as  does the often-used  HIV/AIDS
drug  AZT.  Consequently,  simultaneous  use of  ganciclovir  and AZT  has  been
reported to compound the immunity problems of the AIDS patient since bone marrow
produces  immune  cells in the human  body.  Patients  who use  ganciclovir  may
require  administration  of immune cell enhancement drugs in order to counteract
the adverse effects of ganciclovir.  Cidofovir is administered  intravenously or
intravitreally  by  means  of  a  sustained-release   delivery  system  that  is
surgically implanted in the posterior segment of the eye.

    The Company believes that, with the exception of oral  ganciclovir,  none of
the drugs described above are currently  administered  prophylactically prior to
manifestation of CMV retinitis.




                                       24




    The molecular  structure of Thiovir is identical to that of foscarnet except
that a single  oxygen  atom in  foscarnet  is  replaced  with a  sulfur  atom in
Thiovir.   To  date,   laboratory  in  vitro  tests   conducted  by  independent
laboratories  on human cell  cultures  indicate  that at certain  concentrations
Thiovir is similar to foscarnet in inhibiting CMV replication.  Thiovir has also
been shown in animal studies to partially  convert to foscarnet within the body.
The potential exists,  therefore, that the application of Thiovir will result in
a "double  hit," i.e.,  the portion of Thiovir that  transforms to foscarnet and
the portion that retains its original  chemical  structure would both be present
in the body to control the CMV virus.

    The Company believes that the potential exists for the following benefits to
the use of Thiovir in the treatment of CMV:

    * Thiovir may be  administered  orally.  Initial animal studies suggest that
      Thiovir will  demonstrate  sufficient oral  availability  to humans.  Oral
      dosage is substantially  less intrusive and burdensome than intravenous or
      invitreal administration.

    * Because  of  the  "double  hit"  effect   described  above  and  its  oral
      availability,  Thiovir may prove  equally  effective at lower,  less toxic
      doses than are required with foscarnet.

    * While Thiovir  exhibits some renal  toxicity,  preliminary  animal studies
      suggest  that  Thiovir  may  involve  a lesser  degree of  adverse,  toxic
      consequences than other drugs currently being used.

    * Use of Thiovir may be significantly less costly than alternative drugs for
      many patients  because the cost of  administration  would be insignificant
      and the use of immune cell enhancement drugs would not be required.

    THE  DEVELOPMENT  OF THIOVIR IS IN AN EARLY  STAGE.  TO DATE,  ONLY  LIMITED
LABORATORY  AND ANIMAL  STUDIES HAVE BEEN  CONDUCTED ON THIOVIR.  FURTHER TESTS,
INCLUDING  HUMAN  CLINICAL  TRIALS,  WILL BE NECESSARY TO  DEMONSTRATE  THE ORAL
BIO-AVAILABILITY,  THE EFFICACY AND THE TOXICITY AND OTHER SAFETY  ATTRIBUTES OF
THE USE OF  THIOVIR  FOR THE  TREATMENT  OF  HIV/AIDS  AND CMV.  THERE CAN BE NO
ASSURANCE  THAT SUCH TESTS WILL  ESTABLISH  THAT USE OF THIOVIR  WILL  RESULT IN
THESE BENEFITS.  SEE "RISK FACTORS -- Uncertainty of Product  Development" and "
- -- Uncertainties Related to Clinical Trials."

RESEARCH AND DEVELOPMENT STATUS AND ACTIVITIES

    Research and development  with respect to Thiovir has been performed to date
primarily  at USC under the  direction  of  Professor  Charles E.  McKenna.  See
"MANAGEMENT -- Executive Officers, Directors and Key Consultants" and "PRINCIPAL
STOCKHOLDERS."  In  1994,  PerArdua   Investors,   L.P.,  a  California  limited
partnership (the "Limited  Partnership"),  was formed to fund the development of
Thiovir  through  research  grants  extended  to USC.  The  Limited  Partnership
obtained certain rights to obtain an exclusive  license of the patents and other
intellectual  property rights relating to Thiovir  developed at USC. The Company
acquired such rights in August 1996. See "BUSINESS -- Relationship with USC" and
"CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS."

    In vitro studies conducted at USC have demonstated the ability of Thiovir to
inhibit replication of HIV and CMV and indicating preliminarily that Thiovir may
have favorable oral  bio-availability as compared to CMV drugs currently in use.
An effective  and  relatively  simple  method of  synthesizing  Thiovir was also
developed at USC. The  proprietary  rights of which the Company is the exclusive
licensee include a United States patent for the use of Thiovir for the treatment
of HIV, a U.S.  patent on a method of  synthesis  of Thiovir,  a pending  patent
application, and certain other patent rights. See "BUSINESS -- Patents."

    The Company plans to continue the research and development of Thiovir with a
view to obtaining FDA and other government  approval for its sale and use in the
treatment of HIV/AIDS and active CMV  infection  and to  investigate  additional
potential therapeutic uses.

    The Company is currently  developing  standard operating  procedures for the
production of Thiovir pursuant to GMPs which will meet FDA requirements,  and is
designing and planning laboratory and animal studies intended to satisfy Phase I
requirements of the FDA approval process.  Those studies,  similar in some cases
to the studies already  conducted,  will have the objective of establishing  the
chemical  stability of the product and its toxicity  and  tolerance  properties.
Mutagenicity  and  immunogenicity  studies  may  also  be  performed  if  deemed
necessary.  The Company  expects the completion of these studies and the Phase I



                                       25




process to take six to twelve months, or longer. The production of Thiovir under
GMP standards and the conduct of the Phase I studies will be performed on behalf
of the Company by CROs who have not as yet been  identified by the Company.  The
results of the studies performed during the Phase I process will be submitted to
the FDA as part of an IND,  which must be evaluated and found  acceptable by the
FDA before human  clinical  trials may  commence.  See  "BUSINESS --  Government
Regulation."

RESEARCH AGREEMENT WITH USC

    The  Company  has  recently  entered  into  a new  research  agreement  (the
"Research  Agreement") with USC with respect to Thiovir.  The primary objectives
of the research to be conducted by USC include the following:

    * to acquire  initial in vitro data relating to the potential use of Thiovir
      with  other  HIV  and/or  CMV  inhibitor  drugs  as part of a  combination
      therapy;

    * to conduct additional  research into potential  application of Thiovir for
      treatment of other indications, including non-viral targets;

    * to transfer to the Company  technology  related to Thiovir and to continue
      patent filings related to Thiovir.

    The research at USC will be conducted under the direction of Professor
McKenna and will continue until at least September 30, 1997. The research
is being funded by a grant of approximately $176,000 which has already
been paid by the Company. See "CERTAIN RELATIONSHIPS AND RELATED
TRANSACTIONS."

POTENTIAL MARKET FOR THIOVIR

    Market Size. The World Health Organization estimated at the end of 1996 that
there were more than 22 million people infected with HIV worldwide, of whom more
than eight million had  developed  AIDS.  The United States  Centers for Disease
Control and  Prevention  has  disclosed  that  through  December  1995 more than
500,000  persons in the United States with AIDS had been reported to it and that
approximately  343,000 of them had died.  All HIV/AIDS  patients  represent  the
potential market for Thiovir.

    There are no reliable  figures on the number of AIDS  patients in the United
States or in the world with active CMV infection. One estimate published in 1993
suggested  that 46% of AIDS  patients  suffer in the later stages of the disease
from CMV  retinitis.  Two other 1993  published  estimates  set forth a range of
20-76% and 11-40%.

    Thiovir,  as  well  as the  other  known  drugs  used to  treat  active  CMV
infection,  will not "cure" CMV;  its use would  merely  control  its  symptoms.
Consequently,  use of Thiovir  would be on-going.  Because  active CMV infection
typically  becomes  manifest  within a  patient  in the  latter  stages  of AIDS
infection,  the use of drug therapy to control CMV, at least until recently, was
inevitably  shortened  by the death of the patient.  Treatment of AIDS  patients
using drug combination therapy, however, has recently shown significant clinical
benefits including reduced HIV viral load and increased patient longevity. There
are insufficient data and published reports to determine the effect of these new
therapies  on the  incidence  of new cases of active CMV  infection.  Similarly,
there is  insufficient  published  information  to determine the degree to which
active CMV  infection  may have gone into  remission in those AIDS  patients who
have  benefited  from  combination  drug  therapy,  although  anecdotal  reports
indicate that active CMV  infection is not  significantly  affected  among those
patients.

    Competition.  The  segment  of the  pharmaceutical  industry  engaged in the
treatment of HIV/AIDS and associated  viruses such as CMV is highly  competitive
and rapidly changing. If successfully developed and approved as either an CMV or
HIV drug, or for both indications, Thiovir would compete with numerous therapies
now in existence and currently in development.




                                       26




    Regarding CMV,  Foscarnet is marketed under the name  "Foscavir(R)" by Astra
Pharmaceuticals,  ganciclovir  is marketed under the name  "Cytovene(R)"  by the
Syntex  Division of Hoffman  LaRoche,  and cidofovir is marketed  under the name
"Vistide(R)"  by Gilead  Sciences.  All three  companies  possess vastly greater
organizations,  experience and resources than the Company.  See "RISK FACTORS --
Intense  Competition;  Risk of Technological  Change." The rights to other drugs
known by the Company to be the subject of testing for FDA approval for treatment
of CMV retinitis are held by Chiron Vision,  Isis Corporation,  Gilead Sciences,
Bristol  Myers-Squibb and Glaxo-Wellcome.  Other drugs that are not known to the
Company may be in various stages of development and testing.

    Distributors  of HIV/AIDS  drugs which have been approved by the FDA include
Glaxo-Wellcome,  Merck,  Abbott  Laboratories,  Hoffman  LaRoche,  Bristol-Myers
Squibb and Boehringer-Ingelheim.  These, as well as other companies which can be
expected  to gain FDA  approval  for  HIV/AIDS  drugs,  possess  vastly  greater
organizations, experience and financial resources than the Company.

    The  competitive  factors which the Company expects to encounter when and if
it  obtains  government  approval  for the sale of  Thiovir  are  primarily  the
demonstrated efficacy of a product,  ease of drug administration,  the product's
compatibility  with other drugs being  administered  to HIV/AIDS  patients,  the
relative degree of a product's  adverse side effects,  and the cost of using the
drug,  which would include  associated costs of  administration  and the cost of
drugs that might be taken to ameliorate adverse side effects.

SALES AND MARKETING

    The Company has not yet  formulated a specific  marketing and sales plan for
Thiovir when and if it obtains governmental approval for Thiovir. Similarly, the
Company has no marketing or sales personnel.  In the United States,  the medical
care of a  substantial  percentage  of HIV/AIDS  patients is  concentrated  in a
relatively small number of medical facilities located in urban centers and there
is an extensive flow of information  within the medical community that regularly
provides care to HIV/AIDS patients regarding the safety and efficacy of existing
and newly-developed  therapies.  Moreover,  HIV/AIDS patients support groups are
active and themselves constitute a source of information on drug therapies.  The
Company intends to provide  information to the HIV/AIDS medical community and to
support  groups on a continuous  basis with respect to its progress,  if any, in
further developing Thiovir.  The Company does not expect that a large and costly
marketing and advertising  program will be necessary to acquaint the marketplace
with Thiovir when and if it obtains FDA approval for its sale and use.

MANUFACTURING

    The Company does not have any manufacturing  capacity or relationships  with
third parties and currently  plans to seek to establish a  relationship  with an
unrelated  third  party  manufacturer  for the  manufacture  of  clinical  trial
material and, in the event FDA approval is received,  the commercial  production
of Thiovir. There can be no assurance that the Company will be able to establish
a relationship with a third party manufacturer on commercially  acceptable terms
or that a third party  manufacturer  will be able to  manufacture  products on a
cost-effective  basis in commercial  quantities  under GMPs mandated by the FDA.
The Company does believe, however, that the relatively simple chemical structure
of Thiovir and the methods of synthesizing Thiovir which have been developed and
licensed to the Company will allow an  efficient,  reliable  and  cost-effective
manufacturing process. Nevertheless, the Company's dependence upon third parties
for  manufacturing  may adversely  affect the Company's  profit  margins and its
ability to develop and commercialize  Thiovir on a timely and competitive basis.
Further,  there  can be no  assurance  that  manufacturing  or  quality  control
problems will not arise in connection  with the manufacture of Thiovir or that a
third party  manufacturer  will be able to  maintain  the  necessary  government
licenses  and  approvals to continue  manufacturing.  Any failure to establish a
relationship  with  a  third  party  for  its   manufacturing   requirements  on
commercially  acceptable  terms  would  have a  material  adverse  effect on the
Company.  See "RISK FACTORS -- Dependence on Third Parties for  Development  and
Manufacturing" and "BUSINESS -- Government Regulations."



  
                                       27




GOVERNMENT REGULATION

    The manufacture and sale of Thiovir are subject to government regulations in
the United States and in certain foreign  countries.  In the United States,  the
Company is subject to the rules and regulations established by the FDA requiring
the  presentation of data  indicating  that the Company's  products are safe and
efficacious and are  manufactured in accordance with the FDA's GMP  regulations.
Safety and effectiveness standards are required in certain other countries.  The
Company believes that only a limited number of foreign  countries have extensive
regulatory  requirements,  specifically  the countries  comprising  the European
Union and Japan.

    The  steps  required  to be  taken  before  a new  prescription  drug may be
marketed in the United  States  include (i)  preclinical  laboratory  and animal
tests,  (ii) the  submission  to the FDA of an IND,  which must be evaluated and
found  acceptable by the FDA before human  clinical  trials may commence,  (iii)
adequate and  well-controlled  human clinical trials to establish the safety and
effectiveness  of the drug, (iv) the submission of an NDA to the FDA and (v) FDA
approval of the NDA.  Prior to obtaining FDA approval of an NDA, the  facilities
that will be used to manufacture the drug must undergo a preapproval  inspection
to ensure compliance with the FDA's GMP regulations.

    Preclinical  tests include  laboratory  evaluation of product  chemistry and
animal  studies to assess the safety and  effectiveness  of the  product and its
formulation.  The results of the  preclinical  tests are submitted to the FDA as
part of an IND,  and unless the FDA  objects,  the IND will become  effective 30
days  following  its  receipt  by the FDA.  If the FDA has  concerns  about  the
proposed clinical trial, it may delay the trial and require modifications to the
trial protocol prior to permitting the trial to begin. As a result, there can be
no assurance that the FDA will permit a proposed IND to become effective.

    Clinical trials involve the administration of the pharmaceutical  product to
healthy  volunteers or to patients  identified as having the condition for which
the pharmaceutical is being tested. The pharmaceutical is administered under the
supervision of a qualified principal investigator. Clinical trials are conducted
in accordance with protocols  previously submitted to the FDA as part of the IND
that detail the objectives of the trial,  the parameters  used to monitor safety
and the efficacy  criteria  that are being  evaluated.  Each  clinical  trial is
conducted  under the auspices of an  Institutional  Review Board  ("IRB") at the
institution at which the trial is conducted.  There IRB  considers,  among other
things  ethical  factors,  the  safety of the human  subjects  and the  possible
liability risk for the institution.

    Clinical trials are typically  conducted in three sequential phases that may
overlap. In Phase I, the initial introduction of the pharmaceutical into healthy
human  volunteers,  the  emphasis  is on testing for safety  (adverse  effects),
dosage tolerance, metabolism, distribution, excretion and clinical pharmacology.
Phase II  involves  trials in a limited  patient  population  to  determine  the
effectiveness  of the  pharmaceutical  for  specific  targeted  indications,  to
determine dosage  tolerance and optimal dosage and to identify  possible adverse
side  effects  and safety  risks.  In serious  diseases  such as AIDS,  patients
suffering  from the disease  rather than healthy  volunteers are used in Phase I
trials.  In addition,  Phase I trials may be divided  between Phase Ia, in which
single doses of the drug are given,  and Phase Ib, in which  multiple  doses are
given.  In the  latter  instance,  some  efficacy  data may be  obtained  if the
subjects are patients suffering from the disease rather than healthy volunteers,
and these  trials are referred to as "Phase  Ib/IIa."  After a compound has been
shown in Phase II trials  to have an  acceptable  safety  profile  and  probable
effectiveness,   Phase  III  trials  are   undertaken   to   evaluate   clinical
effectiveness  further and to further test for safety within an expanded patient
population at multiple  clinical study sites.  The FDA reviews both the clinical
trial plans and the results of the trials at each phase and may  discontinue the
trials at any time if there are significant safety issues.

    The results of the  preclinical  tests and clinical  trials are submitted to
the FDA in the form of an NDA for marketing  approval.  The testing and approval
process  is likely to  require  substantial  time and effort and there can be no
assurance that any FDA approval will be granted on a timely basis or at all. The
approval  process is affected by a number of factors,  including the severity of
the  disease,  the  availability  of  alternative  treatments  and the risks and
benefits demonstrated in clinical trials.  Additional animal studies or clinical
trials may be requested  during the FDA review  process and may delay  marketing
approval.  Upon  approval,  a  drug  may  be  marketed  only  for  the  approved
indications  in the approved  dosage  forms.  Further  clinical  trials would be
necessary  to  gain  approval  for  the use of the  product  for any  additional
indications or dosage



                                       28




forms.  The  FDA  may  also  require  post-market   reporting  and  may  require
surveillance  programs to monitor the side effects of the drug, which may result
in withdrawal of approval.

    Many foreign  countries also regulate the clinical  testing,  manufacturing,
marketing and use of pharmaceutical  products.  The requirements relating to the
conduct of clinical trials, product approval, manufacturing,  marketing, pricing
and reimbursement vary widely from country to country. There can be no assurance
that the  Company or any third  parties  with which the  Company  may  establish
collaborative  relationships will be able to attain or maintain  compliance with
such requirements.

    The FDA has  developed  several  regulatory  procedures  to  accelerate  the
clinical   testing  and  approval  of  drugs   intended  to  treat   serious  or
life-threatening  illnesses under certain  circumstances.  For example, in 1988,
the FDA issued regulations to expedite the development, evaluation and marketing
of drugs for life-threatening and severely  debilitating  illnesses,  especially
where no alternative therapy exists (the "1988  Regulations").  These procedures
encourage  early  consultation  between  the  IND  sponsors  and  the FDA in the
preclinical testing and clinical trial phases to determine what evidence will be
necessary  for  marketing  approval  and to assist  the  sponsors  in  designing
clinical trials. Under this program, the FDA works closely with the IND sponsors
to accelerate and condense Phase II clinical  trials,  which may, in some cases,
eliminate  the need to conduct  Phase III trials or limit the scope of Phase III
trials. Under the 1988 Regulations,  the FDA may require post-marketing clinical
trials (Phase IV trials) to obtain  additional  information on the drug's risks,
benefits and optimal use.

    In 1992, the FDA issued regulations establishing an accelerated NDA approval
procedure  for  certain  drugs  under  Subpart H of the  agency's  NDA  approval
regulations  ("Subpart H  Regulations").  The Subpart H Regulations  provide for
accelerated   NDA  approval  for  new  drugs   intended  to  treat   serious  or
life-threatening  diseases  where the drugs  provide  a  meaningful  therapeutic
advantage over existing  treatment.  Under this accelerated  approval procedure,
the FDA may approve a drug based on evidence from  adequate and  well-controlled
studies of the drug's  effect on a surrogate  endpoint that  reasonably  suggest
clinical  benefits,  or on evidence of the drug's effect on a clinical  endpoint
other than survival or irreversible  morbidity.  This approval is conditional on
the  favorable  completion  of trials to  establish  and  define  the  degree of
clinical  benefits to the patient.  Such  post-marketing  clinical  trials would
usually be underway  when the product  obtains this  accelerated  approval.  If,
after approval,  a post-marketing  clinical study establishes that the drug does
not perform as expected, or if post-marketing restrictions are not adhered to or
are not  adequate  to  ensure  the  safe  use of the  drug,  or  other  evidence
demonstrates  that the product is not safe and/or effective under its conditions
of use, the FDA may withdraw approval.  The Subpart H Regulations can complement
the 1988 Regulations for expediting the development, evaluation and marketing of
drugs. These two procedures for expediting the clinical  evaluation and approval
of certain drugs may shorten the drug  development  process by as much as two to
three years.

    The  Company  believes  that  Thiovir  may be a  candidate  for  accelerated
development  and/or  approval  under the 1988  Regulations  and/or the Subpart H
Regulations. There can be no assurance, however, that Thiovir ultimately will be
eligible for development and/or approval under these  regulations.  In addition,
there can be no assurance that Thiovir will be approved by the FDA for marketing
at all or, if approved for marketing, will be approved for marketing sooner than
would be traditionally expected.

    Once the sale of a product is approved, the FDA regulates the manufacturing,
marketing and other  activities  under the Federal Food,  Drug, and Cosmetic Act
and the FDA's  implementing  regulations.  The FDA  periodically  inspects  both
domestic and foreign drug  manufacturing  facilities to ensure  compliance  with
applicable GMP regulations and other requirements. In addition, manufacturers in
the United  States must register with the FDA and submit a list of every drug in
commercial  distribution.  Foreign  manufacturers  are subject  only to the drug
listing  requirement.  The Company does not have or currently  intend to develop
the facilities to manufacture Thiovir in commercial  quantities,  and intends to
establish  a  relationship  with a  contract  manufacturer  for  the  commercial
manufacture of Thiovir.  There can be no assurance  that the Company's  contract
manufacturer will be able to attain or maintain compliance with GMP regulations.
Post-marketing  reports are also  required to monitor  the  product's  usage and
effects.  Product approvals may be withdrawn, or other action as may be ordered,
or  sanctions  imposed  if  compliance  with  regulatory   requirements  is  not
maintained.




                                       29




    The  Company  expects to seek  approval  for Thiovir by the  European  Union
contemporaneously  with seeking approval by the FDA. The processes and standards
of the  European  Union are  similar to those of the FDA and are  subject to the
same  uncertainties   regarding  the  time  of  completion  and  expenditure  of
resources.  The  Company  has no plans at this time to  undertake  the  approval
process  for  Thiovir in Japan or any other  foreign  country.  The  Company may
decide to market  Thiovir,  prior to  obtaining  any FDA  approval,  in  certain
foreign countries that do not require regulatory approval,  although the Company
does not now have any plans for doing so.

    In addition to the import requirements of foreign countries,  a company must
also comply  with  United  States  laws  governing  the export of FDA  regulated
products.  Pursuant to the FDA Export Reform and Enhancement Act of 1996, a drug
that has not  obtained  FDA approval may be exported to any country in the world
without FDA  authorization  if the product  both  complies  with the laws of the
importing  country and has obtained valid marketing  authorization in one of the
following countries: Australia, Canada, Israel, Japan, New Zealand, Switzerland,
South  Africa,  the European  Union,  or a country in the European  Union,  or a
country in the European Economic Area. The FDA is authorized to add countries to
this list in the future. Among other restrictions,  a drug that has not obtained
FDA  approval may be exported  under the new law only if it is not  adulterated,
accords to the specifications of the foreign  purchaser,  complies with the laws
of the importing country,  is labeled for export, is manufactured in substantial
compliance with GMP regulations and is not sold in the United States.

PATENTS

    Patent protection for Thiovir is an important part of the Company's business
strategy,  and the  Company's  success  depends,  in part, on the ability of the
Company and its  licensors  to obtain  patent  protection  for  Thiovir,  defend
patents once  obtained,  use patent  protections  to preclude  competitors  from
marketing Thiovir or substantially  equivalent drugs, operate without infringing
on the patents and  proprietary  rights of third parties and obtain  appropriate
licenses to patents or proprietary  rights held by third parties if infringement
would  otherwise  occur.  The  proprietary  rights of which the  Company  is the
exclusive  licensee  include a U.S.  patent relating to a method of synthesizing
Thiovir,  a U.S.  patent  for the use of  Thiovir  for the  treatment  of HIV, a
pending patent application, and certain other patent rights.

    There can be no assurance that all or any of the Company's patent rights are
enforceable,  will  not  be  invalidated,  or  will  have  sufficient  scope  to
effectively  prevent others from marketing  Thiovir or substantially  equivalent
drugs.  Furthermore,  the commercial  marketing of therapeutic drugs is a highly
competitive  and  litigation-prone  field.  Even if the Company is successful in
establishing  and defending its patent  position,  the costs and management time
associated  with such  activities  may  significantly  and adversely  affect the
financial condition and business operations of the Company. See "RISK FACTORS --
Uncertainty of Patents; Dependence on Patents, Licenses and Proprietary Rights."

    The  Company  is not  aware  of any  United  States  patent  which  would be
infringed by the manufacture of Thiovir,  pursuant to the method of synthesizing
set forth in the licensed  patents rights held by the Company,  and the sale and
use of Thiovir for HIV/AIDS and CMV.  There can be no assurance,  however,  that
the Company is aware of all patents or patent  applications  that may materially
affect the Company's ability to make, use or sell Thiovir.  United States patent
applications are confidential while pending in the PTO, and patent  applications
filed in foreign  countries  are often first  published six months or more after
filing. Any conflicts resulting from third party patent applications and patents
could  significantly  reduce the coverage of the patents licensed to the Company
and limit the ability of the Company or its licensor to obtain meaningful patent
protection. If patents are issued to other companies that contain competitive or
conflicting  claims,  the Company  may be  required to obtain  licenses to these
patents  or to  develop  or  obtain  alternative  technology.  There  can  be no
assurance that the Company will be able to obtain any such license on acceptable
terms or at all. If such licenses are not obtained, the Company could be delayed
in or prevented from pursuing the development or  commercialization  of Thiovir,
which would have a material adverse effect on the Company.




                                       30




RELATIONSHIP WITH USC

    The Company holds an exclusive  worldwide license from USC (the "USC License
Agreement") to practice the inventions  covered by specified  patents related to
TPFA in order  to  manufacture  and sell  products  for the  treatment  of viral
infections  ("Products").  The Company's  exclusive licensing rights are subject
to: (i) nonexclusive  rights that may be held by the United States government as
a result of any funding of research related to the inventions,  as prescribed by
federal  law;  and (ii) USC's  reserved  but  non-transferable  right to conduct
research relating to the Products.  In addition,  all sub-licenses granted under
the license  must be approved in advance and in writing by USC,  but the license
provides that such approval shall not be unreasonably withheld. The Company will
be  obligated to pay to USC  royalties  equal to 1% of any sales of the Products
and 50% of any royalties  earned by the Company from any  sublicensees.  Minimum
annual  royalties  are payable,  starting at $12,500 in 1998 and  increasing  to
$125,000 in 2001 and each year thereafter.

    USC is  obligated  under the USC License  Agreement to file,  prosecute  and
maintain certain United States patents and, if required by the Company, to file,
prosecute and maintain  foreign  patents.  The Company is obligated to reimburse
USC for the legal expense of patent prosecution,  plus a 15% administrative fee.
USC has no  obligation  to defend any of the  patents  while the Company has the
right to do so at its own expense  (with  certain  rights to offset a portion of
royalties  otherwise owing to USC). The Company has a first right to bring legal
action to enforce  the  patents,  and USC may bring such  action if the  Company
elects not to exercise its right. The USC License  Agreement also extends to the
Company  a  right-of-first-refusal  to  obtain an  option  and  license  for any
substantial  improvements to the subject technology  developed by Dr. McKenna on
the same terms and conditions as the USC License Agreement.

    In January 1997, the Company entered into a new research  agreement with USC
providing  for the grant by the Company of $176,000 to fund further  research on
Thiovir  through  September 30, 1997. See "BUSINESS -- Research and  Development
Status and Activities."

OTHER PRODUCTS

    The Company has no current plans or strategies  for  developing or acquiring
products  other than  Thiovir.  The Company  intends,  however,  to  investigate
potential  therapeutic  applications  of  Thiovir  other than the  treatment  of
HIV/AIDS and CMV,  some of which have been  suggested by in vitro  studies.  The
Company may explore  possibilities of developing or acquiring  medical products,
the  development  and/or  marketing  of  which  would  be  compatible  with  the
activities of the Company with respect to Thiovir.

HEALTH CARE REFORM MEASURES AND THIRD PARTY REIMBURSEMENT

    The  business  and  financial  condition of  pharmaceutical  companies  will
continue to be affected by the efforts of governments  and third party payors to
contain or reduce the cost of health care  through  various  means.  A number of
legislative  and regulatory  proposals  aimed at changing the health care system
have been  proposed in recent  years.  In addition,  an  increasing  emphasis on
managed care in the United States has and will continue to increase the pressure
on pharmaceutical  pricing. While the Company cannot predict whether legislative
or regulatory  proposals will be adopted or the effect such proposals or managed
care efforts may have on its business,  the announcement and/or adoption of such
proposals or efforts could have a material adverse effect on the Company. In the
United States and elsewhere, sales of prescription pharmaceuticals are dependent
in part on the  availability of  reimbursement  to the consumer from third party
payors,   such  as  government   and  private   insurance   plans  that  mandate
predetermined  discounts from list prices.  Third party payors are  increasingly
challenging the prices charged for medical products and services. If the Company
succeeds in bringing  Thiovir to the market,  there can be no assurance  that it
will be considered cost effective or that  reimbursement to the consumer will be
available  or will be  sufficient  to allow the  Company  to sell  Thiovir  on a
competitive  and  profitable  basis.  See "RISK FACTORS -- Uncertainty of Health
Care Reform Measures and Third Party Reimbursement."




                                       31




PERSONNEL

    The Company currently has two employees. The Company intends to utilize from
time to time the services of consultants and independent  contractors to provide
key functions that might  otherwise be provided by  Company-employed  personnel.
The  Company's  future  success  will  depend in large part upon its  ability to
attract and retain  highly  qualified  employees,  consultants  and  independent
contractors. See "RISK FACTORS -- Dependence on and Need to Hire Personnel."

LEGAL PROCEEDINGS

    The Company is not involved in any litigation.





                                       32




                                   MANAGEMENT


EXECUTIVE OFFICERS, DIRECTORS AND KEY CONSULTANTS

    The executive  officers,  directors and key  consultants  of the Company and
their ages, as of February 3, 1997, are as follows:


<TABLE>
<CAPTION>
                    NAME                       AGE                  POSITION
                    ----                       ---                  --------
<S>                                            <C>   <C>
Francis E. O'Donnell, Jr., M.D.                47    Chairman of the Board, President,
                                                      Chief Executive Officer and Director
Samuel P. Sears, Jr.                           53    Treasurer, Secretary and Director
Mary Anthony Gray                              49    Executive Vice-President and Chief
                                                      Operating Officer
Emanuela I. Charlton, Ph.D.(1)(2)              63    Director and Consultant
Thomas Quinn (1)(2)                            47    Director
W. Howard Lewin, M.D. (1)(2)                   76    Director
Charles E. McKenna, Ph.D.                      52    Consultant
Thomas D. Wolfe                                48    Consultant




- ------------
(1) Member of the Compensation Committee
(2) Member of the Audit Committee
</TABLE>

    Each of the executive  officers and directors (other than Dr. Lewin) assumed
their  responsibilities  with the  Company in 1996 at the time of the  Company's
acquisition  of a license of  certain  rights to  Thiovir.  Dr.  Lewin  became a
director in December 1996.

    The Company's Certificate of Incorporation  provides that the Board shall be
classified as nearly as possible into three classes, each containing,  as nearly
as  possible,  one-third  of the  members of the Board.  A  classified  Board is
designed  to assure  continuity  and  stability  in the Board's  leadership  and
policies.  Emanuela  I.  Charlton  and Thomas  Quinn are  classified  as Class I
directors  and  shall  serve  until the 1997  annual  meeting  of the  Company's
stockholders (the "Annual Meeting");  W. Howard Lewin, M.D. and Samuel P. Sears,
Jr. are  classified  as Class II directors and shall serve until the 1998 Annual
Meeting;  and  Francis E.  O'Donnell,  Jr.,  M.D. is  classified  as a Class III
director  and shall serve until the 1999 Annual  Meeting.  Each  successor  to a
director  whose term expires at an Annual Meeting will be elected to serve until
the third  succeeding  Annual Meeting after his or her election and until his or
her successor has been duly elected and qualified. Any director chosen to fill a
vacancy on the Board shall hold office until the next  election of the class for
which he or she shall have been chosen,  and until his or her  successor is duly
elected and qualified.  Officers are elected by, and serve at the discretion of,
the Board. No director, executive officer, or significant employee or consultant
is related by blood,  marriage  or  adoption  to any other  director,  executive
officer, or significant employee or consultant.

    The  following  is a brief  summary  of the  background  of  each  director,
executive officer and key consultant of the Company:

    FRANCIS  E.  O'DONNELL,  JR.,  M.D.,  Chief  Executive  Officer,  President,
Chairman of the Board and  Director.  Since  1994,  Dr.  O'Donnell  has been the
Medical  Director  of the  O'Donnell  Eye  Institute  and a Clinical  Professor,
Department of Ophthalmology, at the St. Louis University School of Medicine. Dr.
O'Donnell also serves as Chairman of the Board of  LaserSight,  Inc., a publicly
traded  corporation  which  manufactures  medical  laser  equipment and provides
managed  medical  care  services.  Dr.  O'Donnell  is a  graduate  of St.  Louis
University and Johns Hopkins  University  School of Medicine and is a practicing
ophthalmologist.



                                       33


    SAMUEL P. SEARS,  JR.,  Treasurer,  Secretary and Director.  Since 1994, Mr.
Sears has been  employed as the Chief  Executive  Officer and a director of Star
Tobacco Corporation,  a privately-owned  manufacturer of tobacco products.  From
1993 to 1994,  he served as "of  Counsel"  to the New York law firm of  LeBoeuf,
Lamb, Greene & MacRae.  Prior to 1993, Mr. Sears was the Managing Partner of the
Boston law firm of Burns & Levinson for over twelve years. He is also a director
of  Eye  Technology,  Inc.,  a  publicly-owned  corporation  which  manufactures
intraocular lenses used in cataract surgery.  Mr. Sears is a graduate of Harvard
College and Boston College Law School.

    MARY ANTHONY GRAY,  Executive  Vice-President  and Chief Operating  Officer.
Since 1991, Ms. Gray has served as a biomedical  technology  transfer advisor to
the University of Southern  California.  Since 1986, she has also been a partner
of BioStrategies  International,  a technology consulting firm. Ms. Gray's prior
experience includes business  development and sales positions with the following
companies:  Damon Biotech, Inc., Ortho Diagnostics Division of Johnson & Johnson
and the J.T. Baker Instruments Division of  Richardson-Merrill  Pharmaceuticals.
Ms. Gray holds B.S. and M.S. degrees from the University of Missouri.

    EMANUELA I.  CHARLTON,  PH.D.,  Director  and  Consultant.  Since 1994,  Dr.
Charlton  has  served  as the  Director  of  Regulatory  Affairs  of  LaserSight
Technologies,  Inc.,  a  manufacturer  of  excimer  and solid  state  lasers for
ophthalmic  purposes.  In  addition,  since 1991,  Dr.  Charlton has served as a
director of its parent company, LaserSight, Inc., a publicly traded corporation.
Since 1985, she has been the President of North American Health Resources, Inc.,
a medical  affairs  consulting  firm which she  founded.  Dr.  Charlton has held
positions,  primarily  in the fields of medical  regulatory  affairs and medical
research,  with the following  companies:  High Stoy Technological  Corporation,
Baxter-Travenol,  Inc.,  Searle  Laboratories,  Abbott  Laboratories  and Pfizer
Laboratories.  She holds B.A. and M.S.  degrees from New York  University  and a
Ph.D. degree from The Union Institute Graduate School.

    THOMAS QUINN,  Director.  Since 1995, Mr. Quinn has served as Vice President
of Development of Olsten  Kimberly  Quality Care, a managed health care company.
From 1992 to 1995,  Mr.  Quinn  was Vice  President,  Marketing  and  Sales,  of
Integrated  Health Services,  Inc., a managed health care company.  From 1989 to
1992,  he served as  President  of Infu Tech,  Inc.,  a national  home  infusion
therapy company. Mr. Quinn currently serves as a director of LaserSight, Inc., a
publicly-owned corporation. Mr. Quinn holds a B.S. degree from the University of
Pittsburgh.

    W.  HOWARD  LEWIN,  M.D.,  Director.  Since  1960,  Dr.  Lewin  has been the
President and Medical Director of Lewin & Milster Ophthalmology, Inc., a private
medical  practice.  In addition,  since 1975,  Dr. Lewin has been  employed as a
Clinical  Professor  of  Ophthalmology  at the St.  Louis  University  School of
Medicine.  Dr.  Lewin  received a B.A.  degree from  Central  College,  Fayette,
Missouri and an M.D. degree from the St. Louis University School of Medicine.

    CHARLES E. MCKENNA,  PH.D.,  Consultant.  Since 1989, Dr. McKenna has been a
Professor of Chemistry at USC. Dr. McKenna is the inventor of the two patents of
which the Company is the exclusive licensee, and he has directed the research of
TPFA conducted at USC pursuant to research grants formerly  provided by PerArdua
Investors,  L.P., the partnership  from which the Company  obtained the licenses
related to Thiovir.  Dr.  McKenna will serve as  consultant to the Company for a
period of time ending  three years after the date of the  Offering or until June
30, 2000,  whichever  first  occurs.  Dr.  McKenna  received a B.A.  degree from
Oakland  University and a P.H.D.  in Chemistry from the University of California
at San Diego.

    THOMAS  D.  WOLFE,  Consultant.  Since  1993,  Mr.  Wolfe has been the Chief
Executive  Officer  of  Palmyra  Group,   Inc.,  a  company  providing  chemical
engineering process consulting services and related software services. From 1991
to  1993,  he was a  managing  director  of HPD,  Incorporated,  a  retailer  of
evaporization and crystallization  systems.  Mr. Wolfe was a founder of PerArdua
Investors,  L.P.  The Company  expects to engage the  services of Mr. Wolfe from
time to time to consult on manufacturing, marketing and other matters. Mr. Wolfe
received a B.A.  degree in Chemistry  from the  University  of California at San
Diego.



                                       34


    Dr.  O'Donnell and Mr. Sears expect to devote  approximately  one-quarter of
their  business  time to the affairs of the Company.  Ms. Gray expects to devote
approximately three-quarters of her business time to the affairs of the Company.

COMMITTEES OF THE BOARD OF DIRECTORS

    The Board has established an Audit  Committee and a Compensation  Committee,
each composed of at least two independent  directors.  Currently,  the Company's
three outside  directors,  Mr. Quinn, Dr. Lewin and Dr. Charlton,  serve on both
committees.  The Audit  Committee  will  recommend  the  annual  appointment  of
auditors,  with  whom the Audit  Committee  will  review  the scope of audit and
non-audit  assignments  and  related  fees,  accounting  principles  used by the
Company in financial reporting, internal auditing procedures and the adequacy of
the internal control procedures of the Company. The Compensation  Committee will
establish  salaries,  bonuses and other compensation for the Company's executive
officers and administer the Company's  Incentive Plan and other employee benefit
plans.

EXECUTIVE COMPENSATION AND OTHER INFORMATION

    Summary of Cash and Certain Other Compensation.  No executive officer of the
Company earned or received in excess of $100,000 for any fiscal year ended on or
prior to November 30, 1996. Dr. O'Donnell has not received any compensation from
the Company in any fiscal year.  As a group,  the Company's  executive  officers
(three individuals, only one of whom received or earned any compensation) earned
and received  $11,230  during the fiscal year ended  November  30, 1996,  and no
compensation during any prior period.

    Stock  Option  Grants.  On August 20,  1996 the  Company  issued  options to
purchase  10,000  shares of the  Company's  Common  Stock to Mary  Anthony  Gray
pursuant to the Incentive  Plan.  The options  granted have an exercise price of
$7.50 per share.  The options  granted to Ms. Gray vest on September 3, 1997 and
expire on  September 2, 2001.  The options were the only options  granted by the
Company in the 1996 fiscal year.

    Director Compensation. The Company's directors have not been compensated for
the services they provide to the Company.  Upon the  completion of the Offering,
the Company  plans to issue  options to acquire  10,000  shares of Common  Stock
pursuant to the Incentive Plan to each of Dr. Charlton,  Dr. Lewin and Mr. Quinn
at an exercise  price to be determined,  but not less than $5.00 per share.  The
Company's  directors  receive  reimbursement  for  any  out-of-pocket   expenses
incurred in attending meetings of the Company's Board.

    Employment  Contracts and  Termination of Employment  and  Change-in-Control
Arrangements. The Company has entered into an employment agreement with Ms. Gray
which  provides  for  monthly  compensation  of $5,000 and payment of $1,000 for
non-accountable office expenses.  This Agreement will terminate upon the earlier
of October 6, 1997 or the completion of the Offering. Assuming the completion of
the Offering,  the Company plans to enter into another employment agreement with
Ms.  Gray.  As of the date  hereof,  the Company has not entered  into any other
employment  contracts or any compensatory plans or arrangements  relating to the
resignation,  retirement or other termination of any of the Company's  executive
officers.  Similarly,  as of the date of this  Prospectus,  the  Company has not
entered into any plan or agreement pursuant to which an executive officer of the
Company  will receive any funds upon the  change-in-control  of the Company or a
change in his or her responsibilities following a change-in-control.

    The  Company  has  entered  into  a  consulting   agreement   (the  "McKenna
Agreement")  with Charles E. McKenna,  Ph.D. which continues until September 30,
1999. The McKenna  Agreement  provides that Dr.  McKenna,  who is a Professor of
Chemistry at USC and who is the inventor of the two issued  patents to which the
Company holds an exclusive license from USC, will provide consulting services to
the Company  upon  matters  which  relate to the field of  chemistry  and to the
development  of  Thiovir,  subject to his  obligations  to USC.  The  Company is
obligated to pay Dr. McKenna a retainer of $5,000 for the period October 1, 1996
through  March 31, 1997,  $5,000 for the period April 1, 1997 through  September
30, 1997,  $12,500 for the period October 1, 1997 through September 30, 1998 and
$15,000 for the period October 1, 1998 through  September 30, 1999. In addition,
the Company will pay a fee to Dr.  McKenna for actual  services  rendered at the
rate  of  $1,000  per day or $600  per  half  day  and  will  reimburse  him for
out-of-pocket



                                       35


    expenditures incurred in the performance of his services to the Company. The
McKenna  Agreement  contains  (i) certain  restrictive  covenants  limiting  Dr.
McKenna's right to engage in the development or  commercialization of drugs that
might  compete  with  Thiovir,  (ii)  confidentiality   provisions,   and  (iii)
provisions  relating to the  assignment  to the  Company of certain  inventions,
improvements  and  modifications  made by him  during  the  term of the  McKenna
Agreement.  The rights and  obligations of the Company and Dr. McKenna under the
McKenna Agreement are subject to Dr. McKenna's obligations to USC, which include
assignment  of all rights to  intellectual  property  he develops in his area of
expertise  and  restrictions  on the  amount of time he  devotes  to  consulting
activities.  Dr.  McKenna  is also the  principal  investigator  in the  ongoing
research  concerning  Thiouir  being  conducted  under the  Company's  sponsored
research  agreement  with  USC.  See  "BUSINESS  --  Relationship  with USC" and
"CERTAIN TRANSACTIONS."

INCENTIVE PLAN

    On July 5, 1996,  the Board  adopted  and the  stockholders  of the  Company
approved the  Company's  Incentive  Plan.  The  Incentive  Plan provides for the
granting   to   employees,   officers,   directors,   consultants   and  certain
non-employees  of the Company of (i) options to purchase  shares of Common Stock
and (ii) stock  appreciation  rights  ("SARs").  The maximum number of shares of
Common Stock that may be issued pursuant to options and SARs under the Incentive
Plan is 500,000,  subject to  adjustment  in the event of a stock  split,  stock
dividend or other  change in the Common  Stock or the capital  structure  of the
Company.  The Incentive Plan will be administered by the Compensation  Committee
of the Board of Directors.  Subject to the provisions of the Incentive Plan, the
Compensation  Committee  will be authorized to determine who may  participate in
the  Incentive  Plan,  the  number and type of awards to each  participant,  the
schedule on which each award will become  exercisable and the terms,  conditions
and limitations  applicable to each award. The Compensation  Committee will have
the exclusive  power to interpret the Incentive Plan and to adopt such rules and
regulations  as  it  may  deem   necessary  or   appropriate   for  purposes  of
administering the plan. Subject to certain  limitations,  the Board of Directors
will be authorized to amend,  modify or terminate the Incentive Plan to meet any
changes in legal requirements or for any other purpose permitted by law. 

    Options.  Options granted under the Incentive Plan may be either  "incentive
stock options" within the meaning of Section 422 of the Internal Revenue Code of
1986,  as amended,  or  non-qualified  options.  Incentive  stock options may be
granted  only  to  employees  of  the  Company  (including   directors  who  are
employees),   while  non-qualified   options  may  be  granted  to  non-employee
directors,  employees,  consultants,  advisors and other independent contractors
providing  services to the Company.  The per share  exercise price of the Common
Stock subject to an option granted  pursuant to the Incentive Plan is determined
by the Compensation  Committee at the time the option is granted. In the case of
incentive  stock  options,  the exercise price must not be less than 100% of the
fair market value of the shares covered  thereby at the time the incentive stock
option is granted  (but in no event less than par value).  "Fair  market  value"
shall be determined by the Board, or by its designated committee,  in good faith
and using any reasonable method. No person who owns, directly or indirectly,  at
the time of the granting of an incentive stock option to him, 10% or more of the
total   combined   voting   power  of  all  classes  of  Common  Stock  (a  "10%
Stockholder"),  shall be eligible to receive an incentive stock option under the
Incentive Plan unless the option price is at least 110% of the fair market value
of the Common  Stock  subject to the  option,  determined  on the date of grant.
Non-qualified options are not subject to this limitation.

    No incentive  stock option may be  transferred  by an optionee other than by
will or the laws of descent  and  distribution,  and during the  lifetime  of an
optionee,  the option will be exercisable only by the optionee.  In the event of
termination of employment,  other than by death or permanent,  total disability,
the  optionee  will have three  months  after such  termination  to exercise the
option to the extent it was  exercisable on the date of such  termination.  Upon
termination  of  employment  of an  optionee  by  reason  of death or  permanent
disability,  an option remains exercisable for one year thereafter to the extent
it was  exercisable  on the  date of such  termination.  No  similar  limitation
applies to non-qualified options.

    Incentive stock options granted under the Incentive Plan cannot be exercised
more than 10 years from the date of grant,  except that incentive  stock options
issued to a 10% Stockholder are limited to five year terms.  All options granted
under the  Incentive  Plan may provide for the payment of the



                                       36



exercise  price in cash, by cash  equivalent  acceptable  to the Company,  or by
delivery to the Company of shares of Common Stock  already owned by the optionee
having a fair market  value  equal to the  exercise  price of the options  being
exercised,  or by a  combination  of  such  methods  of  payment.  Therefore,  a
participant may be able to tender shares of Common Stock to purchase  additional
shares of Common Stock and may, theoretically,  exercise all of his or her stock
options with no additional investment other than his or her original shares. Any
unexercised  options that expire or terminate  become  available  once again for
issuance.

    Stock  Appreciation  Rights.  Under the  Incentive  Plan,  the  Compensation
Committee  also may grant SARs  either in tandem  with an option or alone.  SARs
granted  in tandem  with a stock  option  may be granted at the same time as the
stock option or at a later time. A SAR entitles the  participant to receive from
the  Company  an amount  payable  in cash,  in  shares  of Common  Stock or in a
combination  of cash and Common Stock equal to the positive  difference  between
the fair market value of a share of Common Stock on the date of exercise and the
grant price.

    Tax  Consequences.  No income is recognized by a participant  at the time an
option is granted. If the option is an incentive stock option, no income will be
recognized upon the participant's  exercise of the option.  Income is recognized
by a participant  when he or she disposes of shares  acquired under an incentive
stock option. The exercise of a nonqualified stock option generally is a taxable
event that  requires the  participant  to  recognize,  as ordinary  income,  the
difference between the shares' fair market value and the option price. No income
is  recognized  upon the grant of an SAR. The exercise of an SAR  generally is a
taxable event. The participant generally must recognize income equal to any cash
that is paid and the fair  market  value of Common  Stock  that is  received  in
settlement of an SAR. The Company will be entitled to claim a federal income tax
deduction on account of the exercise of a nonqualified option or SAR. The amount
of the deduction is equal to the ordinary income  recognized by the participant.
The Company will not be entitled to a federal income tax deduction on account of
the grant or the exercise of an incentive stock option.  The Company may claim a
federal income tax deduction on account of certain  dispositions of stock issued
upon the exercise of an incentive stock option.

    Change  in  Control  Provisions.  In the  event  of a  "change  in  control"
transaction, the unexercised portion of all outstanding options and SARs granted
pursuant to the Incentive Plan will be fully vested and immediately  exercisable
as of the date which  shall be 15 days prior to the date on which the "change in
control" transaction (as defined below) occurs, after which date all outstanding
options  and SARs will  immediately  terminate  as to any  portion  thereof  not
exercised.  In the event a "change in control"  transaction  does not occur, the
issuance  of shares of Common  Stock  pursuant to the  exercise  of  accelerated
options and all payments  made pursuant to  accelerated  SARs shall be rescinded
and each option and SAR shall remain in effect in accordance  with its terms and
conditions in effect prior to any acceleration of vesting. A "change in control"
transaction  is  defined to  constitute  any of the  following:  (i) a merger or
consolidation in which holders of outstanding  voting stock of the Company would
receive  less  than  50% of the  voting  stock  of the  surviving  or  resulting
corporation;  (ii) adoption by the Company of a plan of  liquidation or approval
of the dissolution of the Company;  (iii) the sale or transfer of  substantially
all of the assets of the Company;  or (iv) a tender offer or exchange  offer for
shares of Common  Stock of the  Company  other  than any such  offer made by the
Company or any corporation affiliated with the Company.

LIMITATION ON OFFICERS' AND DIRECTORS' LIABILITIES

    Pursuant to the  Company's  Certificate  of  Incorporation  and the Delaware
General  Corporation Law, directors of the Company are not liable to the Company
or its stockholders  for monetary  damages for breach of fiduciary duty,  except
for liability in connection with a breach of loyalty,  for acts or omissions not
in good faith or which involve intentional  misconduct or a knowing violation of
law, or for dividend  payments or stock repurchases in violation of Delaware law
or for any  transaction  in which a director  has derived an  improper  personal
benefit.



                                       37


    In addition,  the Company's Certificate of Incorporation includes provisions
to indemnify  its officers and directors  and other  persons  against  expenses,
judgments,  fines and amounts paid in settlement in connection with  threatened,
pending or  completed  suits or  proceedings  against  such persons by reason of
serving or having served as officers,  directors or in other capacities,  except
in relation to matters with respect to which such  persons  shall be  determined
not to have  acted  in good  faith,  lawfully  or in the best  interests  of the
Company.  Except  in the  event  indemnification  is  ordered  by a  court,  the
Company's Certificate of Incorporation  provides for indemnification only to the
extent that the Company determines that such person acted in good faith and in a
manner not opposed to the best interests of the Company.

    Insofar as indemnification  for liabilities arising under the Securities Act
may be permitted to directors,  officers and controlling  persons of the Company
pursuant to the foregoing provisions, or otherwise, the Company has been advised
that in the opinion of the  Commission  such  indemnification  is against public
policy as expressed in the Securities Act and is, therefore, unenforceable.

    Currently, there is no pending litigation or proceeding involving a director
or officer of the Company as to which  indemnification  is being sought,  nor is
the Company  aware of any  threatened  litigation  that may result in claims for
indemnification by any officer or director.



                                       38



                             PRINCIPAL STOCKHOLDERS

The following  table sets forth  certain  information  regarding the  beneficial
ownership of the Common Stock as of the date of this  Prospectus and as adjusted
to reflect the sale of the Common Stock offered hereby of (i) each person who is
known by the  Company to own of record or  beneficially  more than five  percent
(5%) of the  Common  Stock,  (ii) each  director  and  executive  officer of the
Company  and (iii) all  directors  and  executive  officers  of the Company as a
group. Unless otherwise indicated,  each of the persons or entities listed below
has  sole  voting  and  investment  power  with  respect  to  all  shares  shown
beneficially  owned by them,  except  to the  extent  such  power is shared by a
spouse  under  applicable  law. The table also shows  ownership  of  outstanding
warrants to purchase  shares of Common Stock at $10.00 per share,  provided that
the Company has obtained FDA approval for a drug product.


<TABLE>
<CAPTION>
                                                                                       PERCENT OF SHARES
                                                                                        OUTSTANDING(1)
                                                                                        ---------------
                                                                     NUMBER OF       BEFORE         AFTER
NAME AND ADDRESS OF BENEFICIAL OWNER                                 SHARES(2)   OFFERING(2)   OFFERING(2)
- ------------------------------------                                 ----------   ------------   ------------
<S>                                                                  <C>          <C>            <C>
Francis E. O'Donnell, Jr., M.D.(3)(4)                                 280,000         10.6%           7.7%
Samuel P. Sears, Jr.(3)                                                50,000          1.9            1.4
Thomas L. DePetrillo(5)                                               411,250         15.6           11.3
Mary Anthony Gray(3)(6)                                               110,000          4.2            3.0
*Charles E. McKenna, Ph.D.(7)                                         320,000         12.1            8.8
Thomas D. Wolfe(8)                                                    328,930         12.4            9.0
W. Howard Lewin M.D.(9)                                                 5,000          *              *
Thomas Quinn(10)                                                        5,000          *              *
Emanuela I. Charlton, Ph.D.(11)                                         5,000          *              *
The Starwood Trust(12)                                                275,000         10.4            7.5
Yuan Lin(13)                                                          200,000          7.6            5.5
All Directors and Officers as a Group (6 persons)                     455,000         17.2           12.5



- -----------------
 *  Less than 1%.

(1)  Assumes issuance of the Pending Shares.

(2)  Pursuant to the SEC rules,  shares of Common Stock which an  individual  or
     group has the right to acquire  within 60 days  pursuant to the exercise of
     warrants  or  options  are  deemed to be  outstanding  for the  purpose  of
     computing the percentage ownership of such individual or group, but are not
     deemed to be  outstanding  for the  purpose  of  computing  the  percentage
     ownership of any other person in the table.

(3)  The beneficial owner's address is: c/o PerArdua Corporation, 10940 Wilshire
     Boulevard, Los Angeles, California 90024.

(4) Of such shares,  210,000 shares are held by Kathleen O'Donnell as trustee of
    the Irrevocable Trust #4 f/b/o Francis E. O'Donnell, Jr. In addition, 75,000
    shares are held by Kathleen O'Donnell as trustee of the Francis E. O'Donnell
    Descendants  Trust. Dr.  O'Donnell  disclaims  beneficial  ownership of such
    shares.

(5)  Includes 31,250 shares of Common Stock held by Mr. DePetrillo's spouse. Mr.
     DePetrillo  disclaims beneficial ownership of such shares. Mr. DePetrillo's
     address is: 2 Charles Street, Providence, Rhode Island 02904.

(6)  Excludes an option to purchase 10,000 shares of Common Stock at an exercise
     price of $7.50 per share. Such option expires on September 2, 2001.

(7)  Dr. McKenna's address is 16625 Pequeno Place, Pacific Palisades, California
     90272.

(8)  Mr. Wolfe's address is 16288 Gleko Road, Rough and Ready, California 95975.

(9)  Dr. Lewin's address is #8 Ridgecreek, St. Louis, Missouri 63141.



                                       39



(10) Mr. Quinn's address is Nine Corland Trials, Mahwah, New Jersey 07430.

(11) Dr. Charlton's address is 619 Long Lake Drive, Oviedo, Forida 32765.

(12) The Starwood Trust's address is 16 South Market Street, Petersburg,
     Virginia 23803.

(13) Ms. Lin's address is 730 Willow Run Lane, Winter Springs, Florida 32708.
</TABLE>

    The  table  above  does  not  contain  Outstanding  Warrants  issued  to the
individuals  referenced  therein,  which are not  exercisable  until the Company
receives FDA approval for the sale of Thiovir.  These Outstanding  Warrants have
been issued as follows:


<TABLE>
<CAPTION>
                       NAME                         NUMBER OF OUTSTANDING WARRANTS
                       ----                         ------------------------------
<S>                                                             <C>
Francis E. O'Donnell, Jr., M.D.                                 150,000
Thomas L. DePetrillo                                            200,000
Thomas D. Wolfe                                                   8,930
</TABLE>



                                       40


              CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

    In August 1996, the Company issued to three of the then  stockholders of the
Company warrants to purchase an aggregate of 500,000 shares of Common Stock. The
recipients  of these  warrants,  each of whom  paid no  consideration  for their
issuance,  were Francis E. O'Donnell,  Jr., M.D.,  (warrants to purchase 150,000
shares of Common  Stock),  The Starwood  Trust   (warrants  to purchase  150,000
shares of Common Stock), and Thomas L. DePetrillo  (warrants to purchase 200,000
shares of Common Stock). See "MANAGEMENT" and "PRINCIPAL STOCKHOLDERS."

Pursuant  to an Option  and Asset  Purchase  Agreement,  dated July 8, 1996 (the
"Acquisition  Agreement"),  the Company  acquired  certain rights of the Limited
Partnership. Prior to such acquisition, the Limited Partnership was unaffiliated
with the Company and had been formed and operated for the purpose of  conducting
research and development on Thiovir,  primarily  through research grants to USC.
The Company  acquired an  assignment  of the  Limited  Partnership's  rights and
obligations  under an Option and  License  Agreement  by and between the Limited
Partnership  and USC. See "BUSINESS --  Relationship  with USC." The Acquisition
Agreement granted to the Company, in consideration of $100,000, an option, which
was  exercised,  to acquire  the  rights for  $350,000  plus  reimbursement  for
specified  liabilities  which totaled  $90,000,  for a total  purchase  price of
$440,000.  Simultaneously  with the  closing  of the  acquisition  of the rights
pursuant to the Acquisition Agreement,  the Company entered into a Stockholders'
Agreement (the "Stockholders' Agreement") with all of its then stockholders, the
limited  partners of the Limited  Partnership  (the  "Limited  Partners"),  USC,
Charles E. McKenna, Ph.D., Mary Anthony Gray, and Thomas D. Wolfe, the latter of
whom was also a Limited Partner. See "MANAGEMENT" and "PRINCIPAL  STOCKHOLDERS."
Under  the terms of the  Stockholders'  Agreement,  the  Limited  Partners  were
granted  the right to  acquire  a total of  192,000  shares of Common  Stock and
192,000 Outstanding Warrants for total consideration of $192.00; USC was granted
the right to acquire 8,000 shares of Common Stock and 8,000 Outstanding Warrants
for total  consideration of $8.00; and Dr. McKenna,  Ms. Gray and Mr. Wolfe were
granted  the right to acquire  320,000,  110,000  and  320,000  shares of Common
Stock,  respectively,  for total consideration of $320.00, $110.00, and $320.00,
respectively.  All such rights to acquire shares of Common Stock and Outstanding
Warrants  were  exercised.  All  persons  to whom  shares  of  Common  Stock and
Outstanding  Warrants  were issued upon the exercise of such rights are entitled
to certain  registration  rights  with  respect to the Common  Stock  issued and
issuable  upon  exercise  of  the  Oustanding  Warrants.   See  "DESCRIPTION  OF
SECURITIES" -- Common Stock." Mr. Wolfe received,  as a Limited  Partner,  8,930
shares of Common Stock and 8,930 Oustanding  Warrants in addition to the 320,000
shares of Common Stock he acquired  directly from the Company.  Dr.  McKenna and
Mr. Wolfe are consultants to the Company,  and Ms. Gray is an executive  officer
of the Company. See "MANAGEMENT" and "PRINCIPAL STOCKHOLDERS."

    In January  1997,  the Company  entered into a Research  Agreement  with USC
providing for the grant by the Company to USC of $176,000 for continued research
and development of Thiovir. See "BUSINESS -- Relationship with USC." Dr. McKenna
is the  principal  investigator  under the  research  grant and, as such,  it is
expected that he will receive salary and other benefits,  estimated at less than
$25,000, funded by the Company's research grant. See "MANAGEMENT" and "PRINCIPAL
STOCKHOLDERS." In addition,  the Company has entered into a consulting agreement
with  Dr.  McKenna.  Pursuant  to  this  agreement,  Dr.  McKenna  will  provide
consulting  services  related to the  development  of Thiovir  for a term ending
September 30, 1999. The Company will pay Dr. McKenna a semi-annual  retainer and
an hourly fee in  consideration  of such services.  See "MANAGEMENT -- Executive
Compensation and Other Information."

    Emanuela  I.  Charlton,  Ph.D.,  a director  of the  Company,  has  provided
consulting services to the Company for total fees of $3,000 to date. The Company
expects Dr.  Charlton  to provide  on-going  consulting  services to the Company
primarily with respect to the FDA regulatory  process in consideration  for fees
to be negotiated. See "MANAGEMENT" and "PRINCIPAL STOCKHOLDERS."

    Samuel P. Sears, Jr., a director and executive  officer of the Company,  Mr.
Sears received,  in June 1996,  50,000 shares of Common Stock from certain other
stockholders of the Company without paying any monetary  consideration  therefor
as an inducement  for Mr. Sears to become  involved  with the  management of the
Company. See "MANAGEMENT" and "PRINCIPAL STOCKHOLDERS."



                                       41


    Each of Emanuela I. Charlton, Ph.D., Thomas Quinn and W. Howard Lewin, M.D.,
directors of the Company,  received  5,000 shares of the Company's  Common Stock
from  certain   stockholders   of  the  Company   without  paying  any  monetary
consideration  therefor  as an  inducement  to  join  the  Company's  Board.  In
addition,  the Board intends to grant to each of Drs. Charlton and Lewin and Mr.
Quinn,  as of the date of completion of the Offering,  options to acquire 10,000
shares of Common Stock of the Company at an exercise price to be determined, but
in no case less than $5.00 per  share,  pursuant  to the terms of the  Company's
Incentive Plan.

    The Company believes that all of the  transactions  noted above were made on
terms no less  favorable  to the  Company  than  could have been  obtained  from
unaffiliated third parties.




                                       42



                         DESCRIPTION OF SECURITIES

    The  following  summary  description  of  the  Company's  capital  stock  is
qualified  in  its  entirety  by  reference  to  the  Company's  Certificate  of
Incorporation.

COMMON STOCK

    The Company is authorized to issue up to 25,000,000  shares of Common Stock,
$.01 par value per  share.  As of the date of this  Prospectus,  without  giving
effect to the Pending  Shares,  2,593,440  shares of Common Stock are issued and
outstanding and held by 42  stockholders  of record.  Upon the completion of the
Offering,  without  giving  effect to the Pending  Shares,  3,593,440  shares of
Common Stock will be outstanding.

    The holders of Common  Stock are entitled to one vote for each share held of
record  on  each  matter  submitted  to a  vote  of  stockholders.  There  is no
cumulative voting for election of directors, with the result that the holders of
more than fifty  percent of the shares  voting for the election of directors can
elect  all of the  directors.  Subject  to the  prior  rights  of any  series of
Preferred Stock which may from time to time be outstanding,  if any,  holders of
Common Stock are entitled to receive  ratably such  dividends as may be declared
by the  Board  out of  funds  legally  available  therefor  and in the  event of
liquidation,  dissolution,  or winding up of the Company,  are entitled to share
ratably in all assets  remaining  after  payment of  liabilities  and payment of
accrued  dividends and liquidation  preferences on the Preferred  Stock, if any.
Holders of Common Stock have no preemptive  rights and have no rights to convert
their Common Stock into any other securities.  All of the outstanding  shares of
Common  Stock  are,  and the  shares  of  Common  Stock to be  outstanding  upon
completion  of  the  Offering   will  be,   validly   issued,   fully  paid  and
nonassessable.

    Prior to the  Offering and  assuming  the  issuance of Pending  Shares,  the
Company's current principal stockholders  beneficially owned approximately 75.2%
of the  outstanding  shares of Common  Stock of the Company.  Subsequent  to the
Offering,  the Company's  current  principal  stockholders will beneficially own
54.6% of the outstanding shares of the Common Stock of the Company (53.2% if the
Underwriters'  over-allotment  option is exercised in full).  As a result,  they
will  likely  be  able  to  control  all  matters  requiring   approval  by  the
stockholders of the Company, including the election of directors.

    Upon the  completion of the  Offering,  holders of  approximately  2,343,440
shares of Common Stock  (including  the Pending  Shares and the shares  issuable
upon the  exercise  of the  Outstanding  Warrants)  will be  entitled to certain
rights with respect to the registration of such shares under the Securities Act,
subject to certain  limitations.  If the Company proposes to register any of its
securities  under the  Securities  Act,  either  for its own  account or for the
account of other security holders exercising  registration  rights, such holders
are entitled to notice of such  registration  and are entitled to include shares
therein.  These  rights  are  subject  to certain  conditions  and  limitations,
including,  in  certain  circumstances,  the  right  of the  underwriters  of an
offering to limit the number of shares included in such  registration or exclude
all shares.

    The  holders  of the  Representative's  Warrants  also  have the right for a
period of seven years from the  effective  date of this  Prospectus,  to include
shares of Common Stock issuable upon exercise of the  Representative's  Warrants
or  the  Redeemable  Warrants  underlying  the  Representative's  Warrants  (the
"Underlying  Securities")  as part of  certain  other  registered  offerings  of
securities  commenced  by the Company.  In addition,  for a period of five years
from the  effective  date of this  Prospectus,  upon  written  demand of holders
representing  a majority  of the  Representative's  Warrants,  the  Company  has
agreed, on one occasion,  to promptly register the Underlying  Securities at the
Company's expense. Upon receipt of such a request, the Company has agreed to use
its best efforts to file a  registration  statement  registering  the Underlying
Securities.  Finally, for a period of five years from the effective date of this
Prospectus,  upon written demand of any holder of the Representative's Warrants,
the Company has agreed,  on one occasion,  to promptly  register the  Underlying
Securities solely at the expense of such holder.



                                       43



REDEEMABLE WARRANTS

    The following  summary  description of certain  provisions of the Redeemable
Warrants  is  believed  to reflect all  material  provisions  of the  Redeemable
Warrants,  but is not necessarily  complete and reference is made to the Warrant
Agreement  (the  "Warrant  Agreement")  by and between the Company and  American
Securities Transfer & Trust, Inc. (the "Transfer Agent").  The Warrant Agreement
has  been  filed as an  exhibit  to the  Registration  Statement  of which  this
Prospectus is a part for a detailed description thereof.

    Each Redeemable Warrant entitles the holder thereof to purchase one share of
Common  Stock at an  exercise  price of $6.50 per share.  Unless the  Redeemable
Warrants  are  redeemed  as  provided  below,  the  Redeemable  Warrants  may be
exercised  at any time on or before  ______ 2002,  at which time the  Redeemable
Warrants expire.

    The Redeemable Warrants are redeemable by the Company at $.20 per Redeemable
Warrant upon 30 days prior written notice, provided that the average closing bid
price of the Common Stock equals or exceeds $9.00 per share for a 20 consecutive
day trading period ending within 10 days prior to the notice of redemption.  For
purposes of the Warrant Agreement, "average closing bid price" is defined as the
closing  bid price as quoted  on the  Nasdaq  SmallCap  Market.  The  Redeemable
Warrants  may not be  redeemed  unless they are then  exercisable  and a current
prospectus  covering  the  Redeemable  Warrants  and the shares of Common  Stock
issuable  thereunder  is then in effect.  The  Redeemable  Warrants  will remain
exercisable  until the close of business on the fifth  business day prior to the
date of redemption.  Redemption of the Redeemable Warrants may force the holders
to exercise the Redeemable Warrants and pay the exercise price at a time when it
may be disadvantageous  for them to do so or sell the Redeemable Warrants at the
current  market price when they might  otherwise  desire to hold the  Redeemable
Warrants.

    Upon the exercise of the  Redeemable  Warrants more than one year after this
Offering and to the extent not inconsistent  with the guidelines of the National
Association of Securities  Dealers,  Inc., and the rules and  regulations of the
Commission,  the Company has agreed to pay the Representative a commission equal
to five percent of the exercise price of the Redeemable  Warrants.  However,  no
compensation will be paid to the  Representative in connection with the exercise
of the Redeemable  Warrants if (a) the market price of the underlying  shares of
Common Stock is lower than the exercise price,  (b) the Redeemable  Warrants are
exercised in an unsolicited transaction, or (c) the Redeemable Warrants are held
in any discretionary accounts and (d) advance disclosure is made to a Redeemable
Warrant holder. In addition,  unless granted an exemption by the Commission from
Rule 10b-6 under the Exchange Act, the  Representative  will be prohibited  from
engaging in any market making activities or solicited brokerage  activities with
regard to the Company's  securities  for a period of two to nine days before the
solicitation of the exercise of any Redeemable Warrant or before the exercise of
any Redeemable Warrant based upon a prior  solicitation,  until the later of the
termination  of such  solicitation  activity  or the  termination  by  waiver or
otherwise  of any right the  Representatives  may have to  receive a fee for the
exercise of the Redeemable Warrants following such solicitation.

    The holders of the  Redeemable  Warrants  will not have any of the rights or
privileges of  stockholders  of the Company (except to the extent they otherwise
own  Common  Stock)  prior  to the  exercise  of the  Redeemable  Warrants.  The
Redeemable  Warrants  will be  entitled  to the  benefit of  adjustments  in the
exercise price and in the number of shares of Common Stock  deliverable upon the
exercise  thereof  upon the  occurrence  of certain  events,  including  a stock
dividend, stock split or similar reorganization.

In order for a holder to exercise a Redeemable Warrant,  there must be a current
registration  statement on file with the Commission and various state securities
commissions  to register the shares of Common Stock  underlying  the  Redeemable
Warrants for sale to the holder of the Redeemable  Warrant.  Pursuant to Section
10(a)(3) of the Securities  Act, the  information  contained in this  Prospectus
will be deemed "stale" nine months from the date of this Prospectus. The Company
has agreed, so long as the Redeemable Warrants are



                                       44


outstanding,  to use its best efforts to keep a registration statement effective
under the Securities Act and state securities laws to permit the issuance of the
shares of Common  Stock upon  exercise or exchange of the  Redeemable  Warrants.
Nevertheless,  although the Company  intends to do so, no assurance can be given
that the registration  statement will be kept current,  the failure of which may
result in the  Redeemable  Warrants not being  exercisable or  exchangeable  and
therefore worthless.

REPRESENTATIVE'S WARRANTS

    In  connection  with this  Offering,  the  Company has agreed to sell to the
Representative,  at a price of $.001 per warrant,  warrants to purchase from the
Company  100,000  shares of Common Stock and 100,000  Redeemable  Warrants  (the
"Representative's Warrants"). The Representative's Warrants are exercisable at a
price of $8.00 per share of Common Stock and $.16 per  Redeemable  Warrant (160%
of the respective  initial public offering price of the Securities) for a period
of four years  commencing one year from the effective  date of this  Prospectus.
The shares of Common Stock and the Redeemable Warrants issuable upon exercise of
the  Representative's  Warrants are identical to those offered hereby except for
the exercise prices and that the Redeemable Warrants contained therein cannot be
redeemed.

    The Company has agreed to  register,  at its expense,  under the  Securities
Act,  the  Representative's   Warrants  and/or  the  securities  underlying  the
Representative's  Warrants  at the  request of a  majority  in  interest  of the
holders  thereof.  Such  request may be made at any time during a period  ending
five years from the effective date of this Prospectus.  In addition,  for a five
year period following the effective date of this Prospectus, upon written demand
of any holder(s) of the  Representative's  Warrants,  the Company has agreed, on
one occasion,  to promptly register the underlying  securities for purposes of a
public  offering,  solely at the expense of such  holder(s).  The  Company  also
granted  the  Representative  "piggyback"  registration  rights  concerning  the
Representative's  Warrants and the underlying  securities which may be exercised
at any  time  during  a seven  year  period  after  the  effective  date of this
Prospectus.

    For the term of the  Representative's  Warrants,  the holder thereof has the
opportunity  to  profit  from  a rise  in  the  market  price  of the  Company's
securities  which may result in a dilution of the interest of the  stockholders.
The Company may find it more difficult to raise additional  equity capital if it
should be needed for the  business  of the  Company  while the  Representative's
Warrants are outstanding. At any time when the holders thereof might be expected
to exercise it, the Company would probably be able to obtain  additional  equity
capital on terms more  favorable  than those  provided  by the  Representative's
Warrants. See "RISK FACTORS -- Representative's Warrants."

PREFERRED STOCK

    The  Company is  authorized  to issue up to  1,000,000  shares of  Preferred
Stock,  $.01 par value per share, none of which are issued and outstanding as of
the date of this  Prospectus.  The Preferred  Stock may be issued in one or more
series,  the terms of which may be  determined  at the time of  issuance  by the
Board, without further action by the stockholders, and may include voting rights
(including the right to vote as a series on particular matters),  preferences as
to dividends and  liquidation,  conversion,  redemption  rights and sinking fund
provisions.  The Company has no present  plans for the issuance of any shares of
Preferred  Stock.  The  issuance of any such  Preferred  Stock could  reduce the
rights, including voting rights, of the holders of Common Stock, and, therefore,
reduce the value of the Common Stock. In particular,  specific rights granted to
future  holders of  Preferred  Stock  could be used to  restrict  the  Company's
ability to merge with or sell its assets to a third  party,  thereby  preserving
control of the Company's existing management. See "RISK FACTORS -- Anti-Takeover
Effects of Certificate of Incorporation, Bylaws and Delaware Law."

DELAWARE LAW AND CERTAIN CERTIFICATE OF INCORPORATION AND BYLAW PROVISIONS

    Certain  provisions of the Delaware  General  Corporation Law, the Company's
Certificate of  Incorporation,  Bylaws and the Incentive  Plan, may be deemed to
have an  anti-takeover  effect and may delay,  defer or prevent a hostile tender
offer or takeover  attempt that a stockholder  might consider in his or her best
interest,  including  those  attempts  that might  result in a premium  over the
market price for the shares held by stockholders.



                                       45



DELAWARE ANTI-TAKEOVER LAW

    Section 203 of the Delaware General  Corporation Law ("Section 203") applies
to a  Delaware  corporation  with a class of voting  stock  listed on a national
securities exchange, authorized for quotation on an interdealer quotation system
or held of record by 2,000 or more persons. In general,  Section 203 prevents an
"interested  stockholder"  (defined generally as any person owning, or who is an
affiliate or associate of the  corporation  and has owned in the preceding three
years,  15  percent  or more of a  corporation's  outstanding  voting  stock and
affiliates  and  associates  of  such  person)  from  engaging  in  a  "business
transaction"  (as defined  therein) with a Delaware  corporation for three years
following  the date such  person  became an  interested  stockholder  unless (1)
before such person became an interested  stockholder,  the board of directors of
the corporation approved either the business combination or the transaction that
resulted  in the  stockholder  becoming  an  interested  stockholder;  (2)  upon
consummation  of the  transaction  which resulted in the interested  stockholder
becoming an interested stockholder, the interested stockholder owned at least 85
percent  of the  voting  stock of the  corporation  outstanding  at the time the
transaction  commenced  (excluding stock held by directors who are also officers
of the  corporation  and by employee  stock plans that do not provide  employees
with the rights to determine  confidentially  whether shares held subject to the
plan will be tendered in a tender or exchange offer); or (3) on or subsequent to
the date such person became an interested stockholder,  the business combination
is approved by the board of directors of the  corporation  and  authorized  at a
meeting of stockholders by the affirmative  vote of the holders of two-thirds of
the  outstanding  voting stock of the  corporation  not owned by the  interested
stockholder. Under Section 203, the restrictions described above do not apply to
certain business  combinations  proposed by an interested  stockholder following
the  announcement or notification of one of certain  extraordinary  transactions
involving  the  corporation  and  a  person  who  had  not  been  an  interested
stockholder  during  the  previous  three  years  or who  became  an  interested
stockholder with the approval of a majority of the corporation's directors.

SPECIAL MEETING OF STOCKHOLDERS

    The Company's  Bylaws provide that special  meetings of the  stockholders of
the Company may be called only by the Board.  This  provision  will make it more
difficult for stockholders to take action opposed by the Board.

STOCKHOLDER ACTION BY WRITTEN CONSENT

    The  Certificate  of  Incorporation  provides  that no  action  required  or
permitted to be taken at an annual or special meeting of the stockholders of the
Company may be taken without a meeting.

CLASSIFIED BOARD OF DIRECTORS

    The  Company's  Certificate  of  Incorporation  provides for the Board to be
divided into three classes of directors serving staggered three year terms. As a
result,  approximately  one-third  of the  Board  will  be  elected  each  year.
Moreover, under the Delaware General Corporate Law, in the case of a corporation
having a classified  Board,  stockholders  may remove a director only for cause.
This  provision,  when  coupled  with  the  provision  of the  Company's  Bylaws
authorizing only the Board to fill vacant  directorships  (subject to the rights
of the holders of Preferred  Stock),  will preclude a stockholder  from removing
incumbent  directors  without cause and  simultaneously  gaining  control of the
Board by filling the vacancies created by such removal with its own nominees.

ADVANCE NOTICE REQUIREMENTS FOR STOCKHOLDER PROPOSALS AND DIRECTOR NOMINATIONS

    The Company's  Bylaws  provide that  stockholders  seeking to bring business
before an annual meeting of stockholders, or to nominate candidates for election
as directors  at an annual or a special  meeting of  stockholders,  must provide
timely  notice  thereof in writing  and be  present at such  meeting,  either in
person  or by  representative.  For  the  first  Annual  Meeting  following  the
Offering,  a stockholder's  notice shall be timely if delivered to, or mailed to
and received by, the Company at its  principal  executive  office not later than
the close of  business  on the later of (A) the 75th day prior to the



                                       46


    scheduled  date of such Annual Meeting or (B) the 15th day following the day
on which public announcement of the date of such of such Annual Meeting is first
made by the Company.  For all subsequent annual meetings, a stockholder's notice
shall be timely if  delivered  to, or mailed to and  received by, the Company at
its  principal  executive  office  not less  than 75 days nor more than 120 days
prior to the anniversary  date of the immediately  preceding Annual Meeting (the
"Anniversary Date"); provided,  however, that in the event the Annual Meeting is
scheduled to be held on a date more than 30 days before the Anniversary  Date or
more than 60 days after the Anniversary  Date, a  stockholder's  notice shall be
timely if  delivered  to,  or mailed to and  received  by,  the  Company  at its
principal  executive office not later than the close of business on the later of
(A) the 75th day prior to the scheduled  date of such Annual  Meeting or (B) the
15th day  following  the day on which  public  announcement  of the date of such
Annual Meeting is first made by the Company.  These provisions may preclude some
stockholders  from  bringing  matters  before the  stockholders  at an annual or
special meeting or from making nominations for directors at an annual or special
meeting.

AMENDMENTS TO THE BYLAWS

    The Company's  Certificate of Incorporation  and Bylaws provide that subject
to the rights of the holders of Preferred  Stock,  the majority of all directors
or the vote of holders of two-thirds of the  outstanding  stock entitled to vote
is required  to alter,  amend or repeal the Bylaws;  provided,  however,  if the
Board  has  previously  recommended  the  action  to be taken  to the  Company's
stockholders,  the affirmative  vote of a majority of the stockholders may amend
or repeal the Company's Bylaws.

TRANSFER AGENT AND REGISTRAR

    American  Securities  Transfer & Trust,  Inc.  will  serve as the  Company's
transfer agent and registrar.




                                       47


                                  UNDERWRITING

    The  underwriters  named  below  (the  "Underwriters"),  for whom  Schneider
Securities, Inc. is acting as the Representative, have severally agreed, subject
to the terms and conditions of the Underwriting Agreement (the form of which has
been filed as an exhibit to the  Registration  Statement),  to purchase from the
Company the respective numbers of shares of Common Stock and Redeemable Warrants
set forth opposite their names in the table below.  The  Underwriting  Agreement
provides  that the  obligations  of the  Underwriters  are  subject  to  certain
conditions  precedent and that the  Underwriters  shall be obligated to purchase
all of the shares of Common Stock and Redeemable Warrants, if any are purchased.

<TABLE>
<CAPTION>
                                                 NUMBER OF SHARES         NUMBER OF
                     NAME                         OF COMMON STOCK    REDEEMABLE WARRANTS
                     ----                         ---------------    -------------------
<S>                                               <C>                <C>
Schneider Securities, Inc.

                                                  ---------            ---------
   TOTAL                                          1,000,000            1,000,000
                                                  =========            =========
</TABLE>

    Through  the  Representative,  the  several  Underwriters  have  advised the
Company that they propose to offer the shares of Common Stock and the Redeemable
Warrants to the public at the initial  public  offering  prices set forth on the
cover of this Prospectus. The Representative has advised the Company that it may
allow to  certain  dealers  concessions  of not in  excess  of $.25 per share of
Common Stock and $.005 per Redeemable  Warrant,  of which a sum not in excess of
$.13 per share of Common Stock and $.0025 per Redeemable  Warrant may in turn be
reallaowed by such dealers to other dealers. After the issuance of the shares of
Common  Stock  and  Redeemable   Warrants,   the  public  offering  prices,  the
concessions and the reallowances may be changed.  The Representative has further
advised the Company that it does not expect sales to  discretionary  accounts to
exceed five percent of the total number of Securities offered hereby.

    The  Company  has  agreed  to pay to the  Representative  a  non-accountable
expense  allowance equal to three percent of the total proceeds of the Offering,
of which $50,000 has already been paid.

    The Company has granted an option to the  Underwriters,  exercisable  during
the 45-day period following the effective date of the Underwriting Agreement, to
purchase up to 150,000 shares of Common Stock and/or 150,000 Redeemable Warrants
at the  offering  price  less  underwriting  discounts  and the  non-accountable
expense  allowance.  The  Underwriters  may exercise such option only to satisfy
over-allotments  in the  sale of the  shares  of  Common  Stock  and  Redeemable
Warrants.

    Upon the exercise of the  Redeemable  Warrants more than one year after this
Offering and to the extent not inconsistent  with the guidelines of the National
Association of Securities  Dealers,  Inc., and the rules and  regulations of the
Commission,  the Company has agreed to pay the Representative a commission equal
to five percent of the exercise price of the Redeemable  Warrants.  However,  no
compensation will be paid to the  Representative in connection with the exercise
of the Redeemable  Warrants if (a) the market price of the underlying  shares of
Common Stock is lower than the exercise price,  (b) the Redeemable  Warrants are
exercised in an unsolicited transaction, or (c) the Redeemable Warrants are held
in any discretionary accounts and (d) advance disclosure is made to a Redeemable
Warrant holder. In addition,  unless granted an exemption by the Commission from
Rule 10b-6 under the Exchange Act, the  Representative  will be prohibited  from
engaging in any market making activities or solicited brokerage  activities with
regard to the Company's  securities  for a period of two to nine days before the
solicitation of the exercise of any Redeemable Warrant or before the exercise of
any Redeemable Warrant based upon a prior  solicitation,  until the later of the
termination  of such  solicitation  activity  or the  termination  by  waiver or
otherwise  of any right  the  Representative  may have to  receive a fee for the
exercise of the Redeemable Warrants following such solicitation.

    In  connection  with this  Offering,  the  Company has agreed to sell to the
Representative,  for  nominal  consideration,  warrants  (the  "Representative's
Warrants"),  which  confer the right to purchase up to 100,000  shares of Common
Stock and up to 100,000 Redeemable Warrants.  The Representative's



                                       48



Warrants are initially  exercisable at the price (the "Exercise Price") of $8.00
per  share  of  Common  Stock  and  $.16  per  Redeemable  Warrant  (160% of the
respective  initial public offering price) for a period of four years commencing
one year from the effective date of this Prospectus.  The shares of Common Stock
and Redeemable Warrants issuable upon exercise of the Representative's  Warrants
are identical to those offered hereby.  The  Representative's  Warrants  contain
provisions  providing for  adjustment  of the Exercise  Price and the number and
type of  securities  issuable upon the exercise  thereof upon the  occurrence of
certain  events.  The  Representative's  Warrants  grant to the holders  thereof
certain demand and "piggyback" rights of registration of the securities issuable
upon the exercise  thereof upon the occurrence of certain  events  beginning one
year after the date of this Prospectus.

    The Company has agreed to enter into a three-year  consulting agreement with
the Representative, pursuant to which the Representative will act as a financial
consultant to the Company,  commencing  upon the closing date of this  Offering.
The Representative will make available qualified personnel for this purpose. The
consulting  fee of $3,000 per month for a period of 36 months is payable in full
at the closing of this Offering.

    Certain  principal  stockholders  and the Company  have agreed  that,  for a
period of 13  months  from the date of this  Prospectus,  they will not sell any
securities  (except for shares of Common  Stock  issued  pursuant to exercise of
options  which may be granted  under the  Incentive  Plan and for shares  issued
pursuant   to  the   exercise   of  the   Redeemable   Warrants)   without   the
Representative's   prior  written  consent,  which  shall  not  be  unreasonably
withheld.

    The Underwriting Agreement provides for reciprocal  indemnification  between
the Company and the Underwriters  against certain liabilities in connection with
the Registration Statement, including liabilities under the Securities Act.

    The foregoing is a brief summary of certain  provisions of the  Underwriting
Agreement  and does not  purport  to be a  complete  statement  of its terms and
conditions.  A copy of the Underwriting Agreement is on file with the Commission
as an exhibit to the Registration Statement of which this Prospectus is a part.

    Prior to the Offering,  there has been no public market for the  Securities.
The initial public  offering prices of the shares of Common Stock and Redeemable
Warrants  will  be  determined  by  negotiations  between  the  Company  and the
Representative  and  are  not  necessarily  related  to  the  Company's  assets,
earnings,  or book value or any other  established  criteria  of value.  Factors
considered in  determining  the Offering price of the shares of Common Stock and
Redeemable  Warrants  included  estimates  of  business   potential,   financial
condition,  future prospects,  gross proceeds to be raised,  percentage of stock
owned by officers  and  directors  on the date  hereof,  the type of business in
which the Company engages,  and an assessment of the Company's  management.  The
foregoing  factors  were  evaluated  in  light  of  the  existing  state  of the
securities market.



                                       49



                        SHARES ELIGIBLE FOR FUTURE SALE

    Upon completion of the Offering,  the Company will have 3,593,440  shares of
Common Stock (not including the Pending Shares)  outstanding  (3,743,440 shares,
if the  Underwriters'  over-allotment  option is  exercised  in full).  Of these
shares,  the 1,000,000  shares  offered hereby will be freely  tradable  without
further registration under the Securities Act.

    Up to 100,000  additional  shares of Common  Stock may be  purchased  by the
Representative  after the  first  anniversary  of this  Prospectus  through  the
exercise of the  Representative's  Warrants.  Any and all shares of Common Stock
purchased upon exercise of the Representative's Warrants may be freely tradable,
provided  that  the  Company  satisfies  certain  securities   registration  and
qualification  requirements in accordance with the terms of the Representative's
Warrants. See "UNDERWRITING."

    All of the  presently  outstanding  2,593,440  shares of Common  Stock  (not
including the Pending Shares) are "restricted  securities" within the meaning of
Rule 144 of the  Securities  Act and  will be  eligible  for sale in the  public
market in reliance upon, and in accordance with, the provisions of Rule 144.

    In  general,  Under Rule 144 as  currently  in effect,  a person (or persons
whose  shares  are  aggregated),  including  a person who may be deemed to be an
"affiliate"  of the Company as that term is defined  under the  Securities  Act,
will be  entitled  to sell  within  any  three-month  period a number  of shares
beneficially  owned for at least two years that does not  exceed the  greater of
(i) 1% of the then  outstanding  shares of  Common  Stock,  or (ii) the  average
weekly  trading  volume in the  Common  Stock  during  the four  calendar  weeks
preceding  such  sale.  Sales  under  Rule  144  are  also  subject  to  certain
requirements as to the manner of sale,  notice,  and the availability of current
public  information  about the Company.  However,  a person who is not deemed to
have been an  affiliate  of the Company  during the 90 days  preceding a sale by
such person,  and who has  beneficially  owned the shares of Common Stock for at
least three years, may sell such shares without regard to the volume,  manner of
sale, or notice requirements of Rule 144.

    Prior to this  Offering,  there has been no public  market for the Company's
Securities.  Following this Offering,  the Company cannot predict the effect, if
any,  that  sales of Common  Stock  pursuant  to Rule 144 or  otherwise,  or the
availability of such shares for sale,  will have on the market price  prevailing
from  time  to  time.  Nevertheless,   sales  by  the  current  stockholders  of
substantial  amounts of Common Stock in the public market could adversely affect
prevailing market prices for the Common Stock. In addition, the availability for
sale of a substantial  amount of Common Stock  acquired  through the exercise of
the Redeemable Warrants or the Representative's  Warrants could adversely affect
prevailing market prices for the Common Stock. The Company's officers, directors
and certain holders of 5% of the outstanding  shares of Common Stock have agreed
not to sell the  shares  beneficially  owned by such  persons  during a 12 or 13
month period following the date of this Prospectus  (except for shares of Common
Stock that are subject to the  Underwriters  over-allotment  option) without the
Representative's  consent. In addition,  the Company has agreed that it will not
issue any shares of Common Stock during a 13 month period  following the date of
this Prospectus without the Representative's written consent.



                                       50



                                 LEGAL MATTERS

    The  validity of shares of Common Stock  offered  hereby will be passed upon
for the Company by LeClair Ryan, A Professional Corporation, Richmond, Virginia,
and certain matters for the Underwriters by William M.
Prifti, Esquire, Lynnfield, Massachusetts.

                                     EXPERTS

    The financial statements of the Company as of November 30, 1996 appearing in
this  Prospectus  and  Registration  Statement  have been audited by McGladrey &
Pullen,  LLP,  independent  audtiors,  as set  forth  in  their  report  thereon
appearing  elsewhere  herein  and in the  Registration  Statement  and have been
included  herein in reliance  upon such report given upon the  authority of such
firm as experts in accounting and auditing.

                              AVAILABLE INFORMATION

    The Company has filed with the Commission a  Registration  Statement on Form
SB-2 (as amended from time to time and together  with all exhibits and schedules
thereto, the "Registration  Statement") under the Securities Act with respect to
the Common Stock and the  Redeemable  Warrants to be sold in the Offering.  This
Prospectus constitutes a part of the Registration Statement and does not contain
all the  information  set forth  therein,  certain  portions  of which have been
omitted as permitted by the rules and regulations of the Commission.  Statements
contained in this Prospectus as to the content of any contract or other document
are not  necessarily  complete,  and in each instance,  reference is made to the
copy of such contract or other document filed as an exhibit to the  Registration
Statement,  each  such  statement  being  qualified  in  all  respects  by  such
reference.

    For further  information  regarding  the  Company,  the Common Stock and the
Redeemable Warrants to be sold in the Offering,  reference is hereby made to the
Registration  Statement.  A copy of the  Registration  Statement,  including the
exhibits and schedules thereto, may be inspected by anyone without charge at the
Public  Reference  Section of the Commission at Room 1024,  Judiciary Plaza, 450
Fifth Street, N.W., Washington, D.C. 20549 and at the following Regional Offices
of the Commission:  New York Regional Office, 7 World Trade Center,  13th Floor,
New York, New York 10048; and Chicago Regional Office,  500 West Madison Street,
Suite 1400, Chicago,  Illinois 60661.  Copies of the Registration  Statement and
the exhibits and  schedules  thereto can be obtained  from the Public  Reference
Section of the  Commission  upon  payment of  prescribed  fees.  In addition the
Commission  maintains a Web site that contains  reports,  proxy and  information
statements,  and other information  regarding  issuers that file  electronically
with the Commission. Such information can be accessed free of charge (other than
costs  associated with acquiring access to the Internet) at the Commission's Web
site (http://www.sec.gov).

    Prior to filing the  Registration  Statement of which this  Prospectus  is a
part, the Company was not subject to the reporting requirements of Section 13 or
15(d) of the Securities  Exchange Act. Upon  effectiveness  of the  Registration
Statement,  the Company will become  subject to the  informational  and periodic
reporting  requirements of the Exchange Act, and in accordance  therewith,  will
file  periodic  reports,   proxy  statements  and  other  information  with  the
Commission.  Such periodic reports,  proxy statements and other information will
be available for inspection and copying at the public  reference  facilities and
other regional  officers  referred to above. The Company intends to register the
Securities  offered  by  the  Registration  Statement  under  the  Exchange  Act
simultaneously  with the  effectiveness  of the  Registration  Statement  and to
furnish  its  stockholders  with annual  reports  containing  audited  financial
statements  and  quarterly  reports for the first three  quarters of each fiscal
year containing unaudited interim financial information.

    The  shares  of Common  Stock  and the  Redeemable  Warrants  registered  in
connection  with the  Offering  will be listed on the  Nasdaq  SmallCap  Market.
Reports  and other  information  required  to be filed  with such  market may be
inspected at the offices of the Nasdaq SmallCap  Market at 1735 K Street,  N.W.,
Washington, D.C. 20006.



                                       51



                              PERARDUA CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                          INDEX TO FINANCIAL STATEMENTS


<TABLE>
<CAPTION>
                                                                                                   PAGE
        <S>                                                                                        <C>
        Independent Auditor's Report                                                               F-2

        Financial Statements:

           Balance Sheet                                                                           F-3

           Statement of Activities                                                                 F-4

           Statement of Stockholders' Equity                                                       F-5

           Statement of Cash Flows                                                                 F-6

           Notes to Financial Statements                                                           F-7
</TABLE>


                                      F-1


                          INDEPENDENT AUDITOR'S REPORT

To the Board of Directors
 PERARDUA CORPORATION
 Petersburg, Virginia

    We have audited the  accompanying  balance sheet of PerArdua  Corporation (a
development  stage company) as of November 30, 1996, and the related  statements
of activities,  stockholders  equity, and cash flows for the period from July 5,
1996, date of inception,  to November 30, 1996.  These financial  statements are
the responsibility of the Company's management. Our responsibility is to express
an opinion on these financial statements based on our audit.

    We  conducted  our audit in  accordance  with  generally  accepted  auditing
standards.  Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audit provides a reasonable basis for our opinion.

    In our opinion,  the financial  statements referred to above present fairly,
in all material respects,  the financial position of PerArdua  Corporation as of
November 30, 1996,  and the results of its activities and its cash flows for the
period from July 5, 1996, date of inception,  to November 30, 1996 in conformity
with generally accepted accounting principles.

    The accompanying  financial  statements have been prepared assuming that the
Company  will  continue  as a  going  concern.  As  discussed  in  Note 2 to the
financial statements, the Company has suffered losses from its development stage
activities;  the  Company's  operations  will consist  primarily of research and
development  activities  over the next several  years;  and the Company does not
expect  operating  profits or significant  cash flows from operating  activities
during that period. This raises substantial doubt about the Company's ability to
continue as a going concern.  Management's  plans in regard to these matters are
also  described  in  Note  2.  The  financial  statements  do  not  include  any
adjustments that might result from the outcome of this uncertainty.


                                              MCGLADREY & PULLEN, LLP

Richmond, Virginia
January 24, 1997



                                      F-2



                              PERARDUA CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                                  BALANCE SHEET
                                NOVEMBER 30, 1996



<TABLE>
<CAPTION>
    <S>                                                                                   <C>
                                                ASSETS

    Current Assets:
       Cash and cash equivalents                                                          $    495,421
       Deferred offering costs                                                                  29,718
                                                                                          ------------
          Total current assets                                                                 525,139
                                                                                          ------------
    Organizational costs, net of amortization                                                    6,866
                                                                                          ------------
                                                                                          $    532,005
                                                                                          ============

                                 LIABILITIES AND STOCKHOLDERS' EQUITY
    Current Liabilities:
       Accounts payable                                                                   $     20,036
       Accrued expenses                                                                          1,482
                                                                                          ------------
          Total current liabilities                                                             21,518
                                                                                          ------------

 Commitments (Notes 5 and 6)
    Stockholders' Equity:
       Preferred Stock, par value $.01 per share,  1,000,000 shares  authorized,
       none  issued  --  Common  Stock,  par value  $.01 per  share,  25,000,000
       authorized 2,593,440 shares
         issued and outstanding (Notes 4 and 5)                                                 25,934
       Additional paid-in capital                                                            2,609,739
       Deficit accumulated during the development stage                                     (2,090,690)
       Subscription receivable                                                                 (34,496)
                                                                                          ------------
          Total stockholders' equity                                                           510,487
                                                                                          ------------
                                                                                          $    532,005
                                                                                          ============
</TABLE>

                       See Notes to Financial Statements.



                                      F-3


                              PERARDUA CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                             STATEMENT OF ACTIVITIES
        PERIOD FROM JULY 5, 1996, DATE OF INCEPTION, TO NOVEMBER 30, 1996



<TABLE>
<CAPTION>
    <S>                                                                                   <C>
    Revenue:

       Interest income                                                                    $      1,858
                                                                                          ------------     
    Expense:
       Research and development                                                              2,058,980
       General and administrative                                                               33,568
                                                                                          ------------     
                                                                                             2,092,548
                                                                                          ------------     
          Net loss                                                                        $ (2,090,690)
                                                                                          ============
          Net loss per common share                                                       $       (.81)
                                                                                          ============
          Weighted average common shares outstanding                                         2,593,440
                                                                                          ============
</TABLE>

                    See Notes to Financial Statements.


                                      F-4


                              PERARDUA CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                        STATEMENT OF STOCKHOLDERS' EQUITY
        PERIOD FROM JULY 5, 1996, DATE OF INCEPTION, TO NOVEMBER 30, 1996




<TABLE>
<CAPTION>

                                                                             DEFICIT
                                                                           ACCUMULATED
                                           COMMON STOCK       ADDITIONAL    DURING THE       STOCK                      
                                           ------------        PAID-IN     DEVELOPMENT   SUBSCRIPTION                    
                                         SHARES     AMOUNT     CAPITAL        STAGE       RECEIVABLE       TOTAL        
                                         ------     ------     -------        -----       ----------       -----        
<S>                                    <C>          <C>       <C>          <C>            <C>           <C>             
Stock issued at inception                                                                                               
  retroactively restated to                                                                                             
  reflect 41 2/3 to 1 stock split                                                                                         
  declared on July 5, 1996             1,000,000    $ 10,000  $    90,200  $               $            $   100,200     
                                                                                                                        
Issuance (valued at $1.60 per                                                                                           
  share) for cash and                                                                                                   
  acquisition of technology              950,000      9,500    1,510,500                                  1,520,000     
                                                                                                                        
Issuance (at $1.60 per share)                                                                                           
  for cash, net of issuance costs                                                                                         
  of $48,527                             643,440      6,434    1,009,039                    (34,496)        980,977     
                                                                                                                        
Net loss                                                                    (2,090,690)                  (2,090,690)    
                                       ---------    -------   -----------  -----------     ---------    -----------                 
Balance, November 30, 1996             2,593,440    $25,934   $ 2,609,739  $(2,090,690)    $ (34,496)   $   510,487     
                                       =========    =======   ===========  ===========     =========    ===========
</TABLE>
                                       


                       See Notes to Financial Statements.



                                      F-5



                              PERARDUA CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                             STATEMENT OF CASH FLOWS
        PERIOD FROM JULY 5, 1996, DATE OF INCEPTION, TO NOVEMBER 30, 1996



<TABLE>
<CAPTION>
    <S>                                                                                   <C>
    Development stage activities:

       Net loss                                                                          $ (2,090,690)
       Adjustments to reconcile net loss to net cash used in development
           stage activities:

          Amortization                                                                            237
          Charges to expense for value of stock issued for technology                       1,519,050
          Change in operating assets and liabilities:
              Accounts payable and accrued liabilities                                         20,036
                                                                                         ------------
                 Net cash used in development stage activities                               (551,367)
                                                                                         ------------
    Cash used in investing activities:
       Organization costs                                                                      (7,103)
                                                                                         ------------
    Financing activities:
       Proceeds from issuance of common stock                                               1,130,654
       Offering costs                                                                         (78,245)
                                                                                         ------------
                 Net cash provided by financing activities                                  1,052,409
                                                                                         ------------
    Net increase in cash                                                                      495,421
    Cash, beginning of period                                                                 --
                                                                                         ------------
    Cash, end of period                                                                   $   495,421
                                                                                         ============
</TABLE>



                       See Notes to Financial Statements.



                                      F-6




                              PERARDUA CORPORATION
                          (A Development Stage Company)

                         NOTES TO FINANCIAL STATEMENTS


NOTE 1.  ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    Nature of Business:  PerArdua  Corporation (the Company) was incorporated in
1988. The Company was a "shell" corporation, i.e. without assets or liabilities,
until July 1996, when the Company  acquired from PerArdua  Investors,  L.P. (the
Limited  Partnership)  a license  to  certain  patent  rights  to a drug  called
"Thiovir".  The Company's  operations  will focus on the  development and United
States Food and Drug  Administration  (FDA) approval of Thiovir for treatment of
HIV/AIDS  patients and patients  showing active  infection of the  opportunistic
virus cytomegalovirus (CMV) and, ultimately, commercial sale of the product.

    The  Company  is in the  development  stage.  Its major  activities  through
November  30, 1996 have been  limited to  acquiring a  licensing  agreement  and
conducting  research  and  development  related to its  proposed  product and to
obtaining  equity  capital.  These  activities  have not generated any recurring
revenues;   accordingly,  the  accompanying  financial  statements  include  the
disclosures  required by  Statement  of  Financial  Accounting  Standard  No. 7,
"Accounting and Reporting by Development Stage Enterprises".

    Accounting Estimates:  The preparation of financial statements in conformity
with  generally  accepted  accounting  principles  requires  management  to make
estimates  and  assumptions  that  effect  the  reported  amounts  of assets and
liabilities and disclosures of contingent  assets and liabilities at the date of
the  financial  statements  and the  reported  amounts of revenues  and expenses
during the reporting period. Actual results could differ from those estimates.

    Cash and Cash  Equivalents:  Cash and  cash  equivalents  includes  all cash
balances and highly liquid investments with a purchased maturity of three months
or less.  The Company  places its temporary  cash  investments  with high credit
quality  financial  institutions.  At November  30,  1996,  the Company had cash
balances in excess of insured limits.

    Research and  Development:  Research and  development  costs are expensed as
incurred.

    Income Taxes:  The Company  accounts for income taxes in accordance with the
provisions of Statement of Financial  Accounting  Standard No. 109,  "Accounting
for Income Taxes," which  utilizes an asset and liability  approach to financial
accounting  and reporting for income taxes.  Deferred tax assets are  recognized
for  deductible  temporary  differences  and operating loss and tax credit carry
forwards;   deferred  tax  liabilities  are  recognized  for  taxable  temporary
differences.  Temporary differences are the differences between reported amounts
of assets and  liabilities  and their tax bases.  Deferred income tax assets and
liabilities that will result in taxable or deductible  amounts in the future are
based  on  enacted  laws and  rates  applicable  to the  periods  in  which  the
differences  are expected to affect  taxable  income.  Valuation  allowances are
established  when necessary to reduce deferred tax assets to the amount expected
to be  realized.  The  income  tax  provision  or credit is the tax  payable  or
refundable for the period plus or minus the change during the period in deferred
tax assets and liabilities.

    Net Loss Per Common Share:  Net loss per common share is computed based upon
the weighted  average  number of common shares  outstanding  during the year. As
further  explained  in Note 3, the  Company is in the process of  preparing  its
initial public  offering (IPO) of common stock and warrants.  In accordance with
Securities  and Exchange  Commission  Staff  Accounting  Bulletin  Topic 4D, the
weighted  average  number of common shares  outstanding  includes for the entire
year, all common shares issued below the anticipated IPO price per share.

    Deferred Offering Costs:  Costs incurred in connection with the proposed IPO
have been  deferred  as of  November  30,  1996.  If the IPO is  completed,  the
deferred  offering costs will be deducted from the proceeds and charged  against
additional  paid-in  capital.  If the IPO is not  completed,  such costs will be
charged to operations.



                                      F-7



                              PERARDUA CORPORATION
                          (A Development Stage Company)

                   NOTES TO FINANCIAL STATEMENTS - (CONTINUED)


NOTE 2. GOING CONCERN CONSIDERATIONS AND BASIS OF PRESENTATION

    The accompanying  financial statements have been prepared in conformity with
generally accepted  accounting  principles which contemplate the continuation of
the Company as a going  concern.  However,  during the period from July 5, 1996,
date of  inception,  to  November  30,  1996,  the  Company  incurred  a loss of
$2,090,690.  Such loss was funded  through  proceeds  received  from issuance of
common stock.  Management  believes that the Company's  operations  will consist
primarily of research and  development  activities  over the next several years,
and therefore,  it does not expect the Company to generate  operating profits or
significant cash flows from operating  activities  during that period. To obtain
the  additional  funds it needs to continue its research  activities  at planned
levels during the fiscal year ending November 30, 1997, management believes that
the  Company  will  need  substantial  funds  from  debt  obligations  or equity
financing,  such as its proposed IPO.  Management  cannot provide any assurances
that the Company will be able to obtain such financing.  These  conditions raise
substantial  doubts about the Company's  ability to continue as a going concern.
The accompanying financial statements do not include any adjustments relating to
the  recoverability  and classification of recorded asset amounts or the amounts
and classifications of liabilities that might be necessary should the Company be
unable to continue as a going concern.

NOTE 3. PROPOSED IPO

    On October 24,  1996,  the Company and an  investment  banking firm signed a
letter of intent  whereby the  investment  banking firm agreed to underwrite the
Company's IPO, which is expected to consist of 1,000,000  shares of common stock
at $5.00 per share.  Additionally,  the letter of intent  calls for  issuance of
1,000,000  redeemable warrants at a price of $.10 each with an exercise price of
$6.50 per share of common  stock for a period of 60 months  commencing  thirteen
(13) months from the  effective  date.  The warrants  will be  redeemable by the
Company  commencing  thirteen  (13) months from the  effective  date at $.20 per
warrant,  provided that the average closing bid price of the common stock equals
or exceeds $9.00 per share for 20 consecutive trading days.

    The letter of intent includes an over-allotment option which would allow for
the Underwriter to purchase securities, up to an additional 15% of the offering,
for a period of forty-five (45) days following the effective date solely for the
purpose of covering  any short  position in the  offering.  The Company has also
agreed  to sell  the  underwriter,  for  nominal  consideration,  five  (5) year
warrants  to  purchase  ten  percent  (10%) of the  number of  securities  being
underwritten.  These  warrants will be  exercisable  any time during a period of
four  (4)  years  commencing  one  year  from the  effective  date of the  final
prospectus at a price equaling 120% of the IPO price.

NOTE 4. STOCKHOLDERS' EQUITY

    On July 5, 1996, the Board of Directors and stockholders approved amendments
to the  Company's  Articles  of  Incorporation  that (i) changed the name of the
Company from Home Test Inc. to PerArdua  Corporation;  (ii) converted the no par
common  stock to  common  stock  with a par  value of $0.001  per  share;  (iii)
increased  the  total  number  of  authorized   common  shares  from  30,000  to
10,000,000;  and (iv)  ordered  that each share of Home Test Inc.  no par common
stock be exchanged for 41 2/3 shares of PerArdua  Corporation  common stock, par
value of $0.001 per share.

    Effective   January  1997,   the  Company  was  merged  with  and  into  its
wholly-owned subsidiary PerArdua Corporation,  a Delaware corporation.  The sole
purpose of the merger was to change the Company's  jurisdiction of incorporation
from Missouri to Delaware.  As a result of the merger,  the  surviving  Delaware
corporation  assumed  all of the  assets and  liabilities  of the  Company,  and
holders of shares of common stock in the Missouri  corporation became holders of
the same number of shares of common stock in the Delaware  corporation;  the par
value of common stock was changed from $.001 per share to $.01 per share; common
stock  authorization  was increased to 25,000,000 shares and 1,000,000 shares of
$.01 par value Preferred Stock were authorized for future issuance.



                                      F-8


                              PERARDUA CORPORATION
                          (A Development Stage Company)

                   NOTES TO FINANCIAL STATEMENTS - (CONTINUED)


NOTE 4. STOCKHOLDERS' EQUITY -- (CONTINUED)

    The  changes in the par value of the common  stock and the stock  split have
been retroactively  reflected in the accompanying financial statements and these
notes for the period from inception.

    On August 20, 1996, the Company issued 500,000  warrants for the purchase of
the Company's common stock. The warrants grant the holders the right to purchase
additional  shares of common stock at an exercise price of $10.00 per share. The
warrants can be exercised in whole or in part, from time to time,  following FDA
approval, with a final expiration date of June 30, 2006.

    On October 4, 1996, pursuant to a Private Placement Memorandum, dated August
20,  1996,  the Company  completed  an offering of 665,000  shares of its common
stock at $1.60 per share.  Net  proceeds to the Company were  $1,015,473,  after
related expenses of $48,527.

    During the private  placement  offering the Company  accepted a subscription
from an investor for 21,560 shares of common stock. The total  consideration for
this  subscription  was  $34,496  and has  been  recognized  as an  increase  to
additional paid in Capital.

    On August  20,  1996 the Board of  Directors  approved  the sale of  950,000
shares of common stock and warrants to purchase an additional  200,000 shares of
common stock. As more fully discussed in Note 5 below, the shares were valued at
$1.60 per share,  although the Company only received cash consideration of $.001
per  share  ($950).  The  warrants  grant  the  holders  the  right to  purchase
additional  shares of common stock at an exercise price of $10.00 per share. The
warrants can be exercised in whole or in part, from time to time,  following FDA
approval, with a final expiration date of June 30, 2006.

    The Board of Directors and the  stockholders of the Company approved a stock
incentive plan (the Plan) during 1996. The plan provides for grants of incentive
stock options or stock appreciation  rights only to the Company's  employees and
nonqualified  stock  options  and stock  appreciation  rights  to the  Company's
employees,  directors, members of the advisory board, independent contractors or
consultants  of the Company.  The Company has reserved  500,000 shares of common
stock for  issuance  under the Plan.  The  purchase  price for each  share to be
awarded  or sold and the  exercise  price and the term for each  option or stock
appreciation  right to be granted under the Plan will be determined by the Board
of Directors or its Compensation Committee.

    On August 20, 1996 the Board of Directors  granted an officer of the Company
an  option  under the plan to  purchase  10,000  shares  of  common  stock at an
exercise price of $7.50 per share.  The option will vest one year after the date
employment commences and will remain in effect for a period of five years unless
employment is terminated earlier.

NOTE 5. OPTION AND LICENSE AGREEMENT

    Pursuant to an agreement,  dated July 8, 1996 (the  Acquisition  Agreement),
the Company  acquired  certain rights from the Limited  Partnership.  The rights
acquired   consist  of  an  exclusive   license  to  certain  patent  and  other
intellectual  property rights related to the drug,  Thiovir.  The license rights
are  pursuant to a license  agreement  between the Limited  Partnership  and the
University of Southern California (USC) (the USC License Agreement),  the rights
and  obligations  of which were  transferred  by the Limited  Partnership to the
Company  through an  Assignment,  Assumption  and  Consent  Agreement  among the
Company,  the Limited Partnership and USC. The USC License Agreement contains an
exclusive worldwide license to practice the inventions set forth in any relevant
patents  and patent  applications  of USC  related to  Thiovir.  In return,  the
Limited  Partnership  funded  development of Thiovir through  research grants to
USC. Funding of the research is now the responsibility of the




                                      F-9



                              PERARDUA CORPORATION
                          (A Development Stage Company)

                   NOTES TO FINANCIAL STATEMENTS - (CONTINUED)


NOTE 5. OPTION AND LICENSE AGREEMENT -- (CONTINUED)

Company.  Subsequent to November 30, 1996,  the Company signed an agreement with
USC  providing for $ 176,000 of research  funding for the project.  The research
period will be  effective  through  September  30,  1997,  at which time USC can
request an eight month extension period at no additional cost to the Company.

    Consideration  paid by the  Company  to the  Limited  Partnership  under the
Acquisition  Agreement  consisted of $540,000 cash,  which included  $100,000 of
cash  received  from the initial  stockholders  and $440,000 paid out of the net
proceeds  of the  private  offering  (see  Note 4).  Additionally,  the  limited
partners,  together  with  USC and  three  individuals  who have  been  actively
involved in the  development  of Thiovir,  were  extended  the right,  which was
exercised,  to acquire  950,000  shares of the  Company's  common stock for $950
($.001 per share) along with warrants to purchase 200,000  additional  shares at
$10.00  per share  through  June 30,  2006.  These  warrants  will  only  become
exercisable  upon FDA approval of Thiovir.  The 950,000  shares  issued for $950
were valued at $1.60 per share as determined by the per share amount received in
the private  offering  completed  several  months  after the  completion  of the
transactions contemplated by the Acquisition Agreement.

    Charges  resulting from cash paid ($540,000) and shares issued  ($1,519,000)
under the  Acquisition  Agreement  were  recorded  as research  and  development
expense  since Thiovir is still in an early stage of  development.  The drug has
undergone  certain  laboratory  and  animal  studies,  but  must  still  undergo
successful further studies, as well as in human clinical trials, all pursuant to
protocols yet to be approved by the FDA, in order to be commercially marketable.

    The  Acquisition  Agreement  also contains a provision  whereby the purchase
price shall be adjusted  upward in the event that the Company should sell all or
any  portion of its rights in Thiovir in  consideration  of  $5,000,000  or more
prior to the filing of a registration  statement for its IPO. In that event, the
purchase price payable to the Limited  Partnership by the Company shall be equal
to 49% of the sales proceeds.

    Pursuant to the USC License Agreement (and subsequent Assignment, Assumption
and Consent Agreement), the Company will be obligated to pay royalties to USC in
conjunction  with future sales and to reimburse USC for legal  expenses that may
be incurred in connection  with patent  prosecution  and defense.  Royalties are
payable  equal to 1% of sales of the  products and 50% of any  royalties  earned
from  sublicensees.  Minimum annual royalties are payable starting at $12,500 in
1998, increasing to $125,000 in 2001 and each year thereafter.

NOTE 6. EMPLOYMENT AND CONSULTING AGREEMENTS

    The  Company  has  entered  into  an  employment  contract  with  one of its
stockholders.  The agreement  provides for a monthly salary of $5,000 and office
allowance  of $1,000.  The  stockholder  is required to devote 75 percent of her
business time to the affairs of the Company.  This agreement will continue until
the first to occur of the  following:  (i)  September  1997, or (ii) the closing
date of an underwritten initial public offering.

    On August 20, 1996 the  Company's  Board of  Directors  approved and entered
into a  Consulting  Agreement  with one of its  stockholders  for  research  and
development  activities.  The  agreement's  term  is to be for the  period  from
October 1, 1996 until  September  30, 1999 and requires  retainers of $5,000 for
the period  October 1, 1996 through March 31, 1997,  $5,000 for the period April
1, 1997  through  September  30,  1997,  $12,500 for the period  October 1, 1997
through  September 30, 1998,  and $15,000 for the period October 1, 1998 through
September  30, 1999 and a per diem of $1,000 for each full day and $600 for each
half day of consulting services provided to the Company.



                                      F-10


                              PERARDUA CORPORATION
                          (A Development Stage Company)

                   NOTES TO FINANCIAL STATEMENTS - (CONTINUED)


NOTE 7. INCOME TAXES

    At November 30, 1996, the Company had net operating loss (NOL) carryforwards
available to reduce future taxable income, if any, of approximately  $37,710 for
federal  and state  income  tax  reporting  purposes  that  expire in 2011.  The
Company's  ability  to utilize  the NOL will also be  subject  to annual  limits
established by Internal Revenue Code Section 382.

    The net operating loss  carryforward and a temporary  difference of $540,000
for rights  acquired  under the  Acquisition  Agreement  (see Note 5) could have
resulted in the recognition of deferred tax assets of approximately  $217,000 at
November 30, 1996. However,  due to the uncertainties  inherent in the Company's
operations,  the  deferred  tax assets and the  related tax  benefits  have been
offset by a valuation  allowance  in the same amount and  accordingly,  have not
been reflected in the accompanying financial statements.

    Research and development expense of $1,519,000,  represented by the value of
common stock issued  under the  Acquisition  Agreement,  is not  deductible  for
income tax purposes.




                                      F-11




================================================================================

    NO PERSON HAS BEEN AUTHORIZED IN CONNECTION WITH THE OFFERING MADE HEREBY TO
GIVE  ANY  INFORMATION  OR TO MAKE  ANY  REPRESENTATION  NOT  CONTAINED  IN THIS
PROSPECTUS AND, IF GIVEN OR MADE, SUCH INFORMATION OR REPRESENTATION MUST NOT BE
RELIED UPON AS HAVING BEEN  AUTHORIZED BY THE COMPANY OR ANY  UNDERWRITER.  THIS
PROSPECTUS  DOES NOT  CONSTITUTE AN OFFER TO BUY ANY OF THE  SECURITIES  OFFERED
HEREBY TO ANY PERSON OR BY ANYONE IN ANY JURISDICTION IN WHICH IT IS UNLAWFUL TO
MAKE SUCH OFFER OR SOLICITATION. NEITHER THE DELIVERY OF THIS PROSPECTUS NOR ANY
SALE MAKE HEREUNDER SHALL, UNDER ANY CIRCUMSTANCES,  CREATE ANY IMPLICATION THAT
THE  INFORMATION  CONTAINED  HEREIN IS CORRECT AS OF ANY DATE  SUBSEQUENT TO THE
DATE HEREOF.


                             -----------------

                             TABLE OF CONTENTS



                                                                            PAGE
                                                                            ----

Prospectus Summary                                                            3
Risk Factors                                                                  6
Special Note Regarding Forward
  Looking Statements                                                         16
Use of Proceeds                                                              17
Dividend Policy                                                              17
Dilution                                                                     18
Capitalization                                                               19
Selected Financial Data                                                      20
Management's Discussion and Analysis of
  Financial Condition and Results of
  Operations                                                                 21
Business                                                                     23
Management                                                                   33
Principal Stockholders                                                       39
Certain Relationships and Related
  Transactions                                                               41
Description of Securities                                                    43
Underwriting                                                                 48
Shares Eligible for Future Sale                                              50
Legal Matters                                                                51
Experts                                                                      51
Additional Information                                                       51


    UNTIL ______ , 1997, ALL DEALERS  EFFECTING  TRANSACTIONS  IN THE REGISTERED
SECURITIES, WHETHER OR NOT PARTICIPATING IN THE DISTRIBUTION, MAY BE REQUIRED TO
DELIVER A  PROSPECTUS.  THIS IS IN  ADDITION  TO THE  OBLIGATIONS  OF DEALERS TO
DELIVER A  PROSPECTUS  WHEN  ACTING AS  UNDERWRITERS  AND WITH  RESPECT TO THEIR
UNSOLD ALLOTMENTS OR SUBSCRIPTIONS.

================================================================================

================================================================================


                              PERARDUA CORPORATION
                        1,000,000 SHARES OF COMMON STOCK
                          1,000,000 REDEEMABLE WARRANTS






                                   ----------
                                   PROSPECTUS
                                   ----------







                           SCHNEIDER SECURITIES, INC.



                                         , 1997


================================================================================




                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 24. INDEMNIFICATION OF DIRECTORS AND OFFICERS

    Section  102(b)(7)  of  the  Delaware  General  Corporation  Law  enables  a
corporation in its original certificate of incorporation or an amendment thereto
validly  approved  by the  corporation's  stockholders  to  eliminate  or  limit
personal  liability  of  members  of its Board for  violations  of a  director's
fiduciary duty of care.  However,  the elimination of limitation shall not apply
where  there has been a breach of the duty of  loyalty,  failure  to act in good
faith, engaging in intentional misconduct or knowingly violating a law, paying a
dividend or obtaining an improper personal benefit.

    In addition,  Section 145 of the Delaware General  Corporation Law permits a
corporation  organized  under  Delaware law to indemnify  directors and officers
with respect to any matter in which the director or officer  acted in good faith
and in a manner he or she  reasonably  believed  to be not  opposed  to the best
interests of the Company,  and, with respect to any criminal  action,  he or she
had reasonable cause to believe his or her conduct was not lawful.

    Article  VII,  Section  2 of  the  Company's  Certificate  of  Incorporation
provides as follows:

       Subject to the  operation of Section 4 of this Article VII, each [officer
    and director of the Company] shall be  indemnified  and held harmless by the
    [Company] to the fullest extent authorized by the General Corporation Law of
    the State of Delaware,  as the same exists or may  hereafter be amended (but
    in the  case of such  amendment,  only to the  extent  that  such  amendment
    permits the [Company] to provide  broader  indemnification  rights than such
    law permitted the [Company] to provide prior to such amendment)  against any
    and all [e]xpenses,  judgments, penalties, fines and amounts reasonably paid
    in  settlement  that are  incurred by such  [officer or director] or on such
    [officer's or director's] behalf in connection with any threatened,  pending
    or completed  [p]roceeding or any claim, issue or matter therein, which such
    [officer  or  director]  is,  or is  threatened  to be  made,  a party to or
    participant  in by  reason of such  [officer's  or  director's]  [c]orporate
    [s]tatus,  if such [officer or director] acted in good faith and in a manner
    such  [officer or director]  reasonably  believed to be in or not opposed to
    the best  interests  of the  [Company]  and,  with  respect to any  criminal
    proceeding,  has no  reasonable  cause to  believe  his or her  conduct  was
    unlawful.  The rights of  indemnification  provided by this  Section 2 shall
    continue as to an [officer or director]  after he or she has ceased to be an
    [officer  or  director]  and shall inure to the benefit of his or her heirs,
    executors, administrators and personal representatives.  Notwithstanding the
    foregoing,  the [Company] shall indemnify any [officer or director]  seeking
    indemnification in connection with a [p]roceeding initiated by such [officer
    or  director]  only if such  [p]roceeding  was  authorized  by the  Board of
    Directors of the [Company].

       In  addition,  Article VII,  Section 4 of the  Company's  Certificate  of
    Incorporation provides as follows:

       Unless ordered by a court, no indemnification  shall be provided pursuant
    to this Article VII to an [o]fficer . . . unless a determination  shall have
    been made that such  person  acted in good faith and in a manner such person
    reasonably  believed  to be in or not opposed to the best  interests  of the
    [Company] and, with respect to any criminal [p]roceeding, such person had no
    reasonable  cause  to  believe  his  or  her  conduct  was  unlawful.   Such
    determination  shall be made by (a) a majority  vote of the  [d]isinterested
    [d]irectors,  even though less than a quorum of the Board . . . (b) if there
    are no such [d]isinterested [d]irectors, or if a majority of [d]isinterested
    [d]irectors so direct by independent legal counsel in a written opinion,  or
    (c) by the stockholders of the [Company].



                                      II-1


ITEM 25. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

    The  following  is a list of the  estimated  expenses  to be incurred by the
Company in connection with the issuance and distribution of the shares of Common
Stock being  registered,  other than the underwriting  discount and commissions.
All of the following expenses will be paid by the Company.

<TABLE>
<CAPTION>
<S>                                                                      <C>
Commission Filing Fee                                                  $   4,600.00
Nasdaq SmallCap Fee                                                        5,000.00
NASD Filing Fee                                                            2,000.00
Blue Sky Fees and Expenses                                                15,000.00
Non-Accountable Expense Allowance to the Representative                  153,000.00
Printing and Engraving Expenses                                           50,000.00
Accounting Fees and Expenses                                              25,000.00
Legal Fees and Expenses                                                   75,000.00
Transfer Agent and Registrar Fees                                          5,000.00
Consulting Fees                                                          108,000.00
Miscellaneous Fees and Expenses                                            7,400.00
                                                                        -----------
  TOTAL (Estimated)                                                     $450,000.00
                                                                        ===========
</TABLE>

ITEM 26. RECENT SALES OF UNREGISTERED SECURITIES

    Since  February 5, 1994,  the  Company  has sold and  issued  the  following
unregistered securities:

    On August 12, 1996, the Company issued  warrants to purchase an aggregate of
150,000  shares of Common Stock at $10.00 per share to Samuel P. Sears,  Jr. for
no consideration.

    On August 12, 1996, the Company issued  warrants to purchase an aggregate of
150,000 shares of Common Stock at $10.00 per share to Francis E. O'Donnell,  Jr.
for no consideration.

    On August 12, 1996, the Company issued  warrants to purchase an aggregate of
200,000  shares of Common Stock at $10.00 per share to Thomas L.  DePetrillo for
no consideration.

    On August 16, 1996,  the Company,  in connection  with the  acquisition of a
license of certain  rights to Thiovir,  issued an aggregate of 200,000  warrants
and 200,000  shares of Common Stock to 16 investors for a total  aggregate  cash
consideration of $200.00.  Fifteen of the investors were limited partners in the
limited  partnership which  transferred the license;  the other investor was the
University of Southern California, the licensor under the license.

    On August 16, 1996,  the Company  issued  320,000  shares of Common Stock to
Charles E. McKenna, Ph.D. for $320.00.

On August 16, 1996,  the Company  issued  110,000 shares of Common Stock to Mary
Anthony Gray for $110.00.

    On August 16, 1996,  the Company  issued  320,000  shares of Common Stock to
Thomas D. Wolfe for $320.00.

    On September 8, 1996, the Company  issued options to purchase  10,000 shares
of Common  Stock at an exercise  price of $7.50 per share to Mary  Anthony  Gray
pursuant to the Company's Stock Incentive Plan.

    On October 4, 1996,  the Company  issued an aggregate  of 643,440  shares of
Common Stock to investors for a total, aggregate purchase price of $1,029,504.

    The sales and  issuance of the  securities  in the above  transactions  were
deemed to be exempt under the  Securities  Act by virtue of Sections 3(b) and/or
4(2) thereof  and/or  Regulation D promulgated  thereunder as  transactions  not
involving any public  offering.  The purchasers in each case  represented  their
intention to acquire the securities  for investment  only and not with a view to
the distribution  thereof.  Appropriate legends were affixed to the certificates
issued in such transactions.



                                      II-2




    The Company  intends to issue the Pending  Shares prior to the completion of
the Offering.  In addition,  shortly after the  completion of the Offering,  the
Company also intends to issue  options to purchase an aggregate of 30,000 shares
of Common  Stock to three of the  Company's  outside  directors  pursuant to the
Incentive Plan at an exercise  price to be  determined,  but not less than $5.00
per share.

ITEM 27. EXHIBITS

<TABLE>
<CAPTION>
 EXHIBIT
 NUMBER                                 DESCRIPTION OF EXHIBITS
 ------                                 -----------------------
<S>             <C>
1.1             -- Form of Underwriting Agreement*
1.2             -- Form of Selected Dealers Agreement*
1.3             -- Form of Agreement Among Underwriters*
2.1             -- Option and Asset Purchase Agreement, dated July 8, 1996, by and between PerArdua
                   Investors, L.P. and the Company**                                               
3.1             -- Certificate of Incorporation of Registrant*
3.2             -- Bylaws of Registrant*
4.1             -- Form of Common Stock Certificate**
4.2             -- Form of Stock Purchase Warrant*
4.3             -- Form of Private Placement Subscription Agreement*
4.4             -- Form of Acquisition Transaction Subscription Agreement**
4.5             -- Form of Representative's Warrants*
4.6             -- Form of Warrant Agreement (including form of Redeemable Warrant)**
5.1             -- Opinion of LeClair Ryan, A Professional Corporation**
10.1            -- Option & License Agreement, dated March 28, 1994, by and between PerArdua Investors,
                   L.P. and the University of Southern California**                                    
10.2            -- Stockholders' Agreement, dated July 8, 1996, by and between the Company, the
                   stockholders of the Company, and the limited partners of PerArdua Investors, L.P.**
10.3            -- Research Agreement, dated January 7, 1997, by and between the University of Southern
                   California and the Company*
10.4            -- Consulting Agreement, dated September 30, 1996, by and between the Company and
                   Charles E. McKenna, Ph.D.*
10.5            -- Assignment, Assumption and Consent, dated as of July 31, 1996, by and between
                   PerArdua Investors, L.P., the Company and the University of Southern California*
10.6            -- Form of Consulting Agreement by and between the Company and Schneider Securities,
                   Inc.*
10.7            -- Employment Agreement, dated as of September 3, 1996 by and between the Company
                   and Mary Anthony Gray*
23.1            -- Consent of McGladrey & Pullen, LLP*
23.2            -- Consent of LeClair Ryan, A Professional Corporation (included in Exhibit 5.1 hereto)**
24.1            -- Power of Attorney (see Page II-5)*
27.1            -- Financial Data Schedule*


- --------------

 * Filed herewith.

** To be filed by amendment.
</TABLE>

ITEM 28. UNDERTAKINGS


    The undersigned registrant hereby undertakes:

    (1) To file,  during  any period in which it offers or sells  securities,  a
post-effective amendment to this registration statement to:

       (i) Include any prospectus required by Section 10(a)(3) of the
    Securities Act;




                                      II-3



       (ii) Reflect in the prospectus any facts or events which, individually or
    together,   represent  a  fundamental  change  in  the  information  in  the
    registration  statement.  Notwithstanding  the  foregoing,  any  increase or
    decrease in the volume of  securities  offered (if the total dollar value of
    securities  offered  would not  exceed  that which was  registered)  and any
    deviation from the low or high end of the estimated  maximum  offering range
    may be  reflected  in the  form of  prospectus  filed  with  the  Commission
    pursuant  to Rule  424(b) if, in the  aggregate,  the  changes in volume and
    price represent no more than a 20% change in the maximum aggregate  offering
    price  set  forth in the  "Calculation  of  Registration  Fee"  table in the
    effective registration statement; and

       (iii) Include any additional or changed material information on the
    plan of distribution.

Provided,  however,  that  paragraphs  1(i)  and  1(ii)  do  not  apply  if  the
registration  statement is on Form S-3 or Form S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement.

    (2) That, for the purpose of determining  any liability under the Securities
Act of 1933,  each  such  post-effective  amendment  shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

    (3) To remove from  registration by means of a  post-effective  amendment of
any of the securities being registered which remain unsold at the termination of
the offering.

    Insofar as indemnification  for liabilities arising under the Securities Act
may be permitted to  directors,  officers and  controlling  persons of the small
business issuer pursuant to the foregoing  provisions,  or otherwise,  the small
business  issuer has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against such  liabilities  (other than the payment by the small
business  issuer  of  expenses  incurred  or  paid  by a  director,  officer  or
controlling person of the small business issuer in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities  being  registered,  the small business
issuer will, unless in the opinion of its counsel the matter has been settled by
controlling  precedent,  submit  to a  court  of  appropriate  jurisdiction  the
question  whether  such  indemnification  by  it is  against  public  policy  as
expressed in the Securities  Act and will be governed by the final  adjudication
of such issue.

    The registrant hereby undertakes that:

    (1) For the purpose of determining  any liability  under the Securities Act,
the  information  omitted  from  the  form of  prospectus  filed as part of this
registration  statement  in reliance  upon Rule 430A and  contained in a form of
prospectus  filed by the registrant  pursuant to Rule 424(b)(1)  or(4) or 497(h)
under  the  Securities  Act  shall  be  deemed  to be part of this  registration
statement as of the time it is declared effective.

    (2) For the purpose of determining  any liability  under the Securities Act,
each post-effective amendment that contains a form of prospectus shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and this  offering  of such  securities  at that time  shall be deemed to be the
initial bona fide offering thereof.

    The  undersigned   small  business  issuer  undertakes  to  provide  to  the
underwriters   at  the  closing   specified  in  the   underwriting   agreement,
certificates in such  denominations  and registered in such names as required by
the underwriters to permit prompt delivery to each purchaser.



                                      II-4


                                   SIGNATURES

    IN ACCORDANCE  WITH THE  REQUIREMENTS  OF THE SECURITIES ACT, THE REGISTRANT
CERTIFIES  THAT IT HAS  REASONABLE  GROUNDS TO BELIEVE  THAT IT MEETS ALL OF THE
REQUIREMENTS OF FILING ON FORM SB-2 AND AUTHORIZED THIS  REGISTRATION  STATEMENT
TO BE SIGNED ON ITS BEHALF BY THE  UNDERSIGNED,  IN THE IN THE CITY OF RICHMOND,
COMMONWEALTH OF VIRGINIA, ON FEBRUARY 5, 1997.

                                       PERARDUA CORPORATION


                                       By:  /s/ FRANCIS E. O'DONNELL, JR., M.D.
                                            -----------------------------------
                                              FRANCIS E. O'DONNELL, JR., M.D.,
                                                  CHAIRMAN OF THE BOARD,
                                           PRESIDENT AND CHIEF EXECUTIVE OFFICER

    Each person whose  signature  appears below on this  Registration  Statement
hereby  constitutes and appoints Samuel P. Sears,  Jr. and Francis E. O'Donnell,
Jr., M.D. and each of them, with full power to act without the other, his or her
true and lawful  attorney-in-fact and agent, with full power of substitution and
resubstitution,  for him or her and in his or her name,  place and stead, in any
and all capacities  (until revoked by writing) to sign any and all amendments to
this Registration Statement (including  post-effective amendments and amendments
thereto) and any  registration  statement  relating to the same offering as this
Registration  Statement  that is to be  effective  upon filing  pursuant to Rule
462(b)  under  the  Securities  Act,  and to file the  same,  with all  exhibits
thereto,  and other documents in connection  therewith,  with the Securities and
Exchange Commission,  granting unto said attorneys-in- fact and agents, and each
of them,  full  power and  authority  to do and  perform  each and every act and
thing,  ratifying and confirming all that said  attorneys-in-fact  and agents or
any of them, or their or his substitute or substitutes, may lawfully do or cause
to be done by virtue hereof.

    PURSUANT  TO  THE  REQUIREMENT  OF THE  SECURITIES  ACT,  THIS  REGISTRATION
STATEMENT HAS BEEN SIGNED BY THE FOLLOWING  PERSONS IN THE CAPACITIES AND ON THE
DATES INDICATED:



<TABLE>
<CAPTION>
                     NAME                                      TITLE                       DATE
  <S>                              <C>                                                               <C>
  /s/ FRANCIS E. O'DONNELL, JR., M.D.,           CHAIRMAN OF THE BOARD,             FEBRUARY  5, 1997
  ------------------------------------             PRESIDENT, CHIEF EXECUTIVE
     FRANCIS E. O'DONNELL, JR., M.D.,              OFFICER (PRINCIPAL EXECUTIVE
                                                   OFFICER) AND DIRECTOR

  /s/ SAMUEL P. SEARS, JR.                       TREASURER (PRINCIPAL FINANCIAL     FEBRUARY  5, 1997
  ------------------------------------             OFFICER), SECRETARY AND
         SAMUEL P. SEARS, JR.                      DIRECTOR

  /s/ EMANUELA I. CHARLTON, PH.D.                DIRECTOR                           FEBRUARY  5, 1997
  ------------------------------------
      EMANUELA I. CHARLTON, PH.D.

  /s/ THOMAS QUINN                               DIRECTOR                           FEBRUARY  5, 1997
  ------------------------------------
            THOMAS QUINN

  /s/ W. HOWARD LEWIN, M.D.                      DIRECTOR                           FEBRUARY  5, 1997
  ------------------------------------
      W. HOWARD LEWIN, M.D.
</TABLE>



                                      II-5



                                  EXHIBIT INDEX


<TABLE>
<CAPTION>
 EXHIBIT
 NUMBER                                 DESCRIPTION OF EXHIBITS
 ------                                 -----------------------
<S>             <C>
1.1             -- Form of Underwriting Agreement*
1.2             -- Form of Selected Dealers Agreement*
1.3             -- Form of Agreement Among Underwriters*
2.1             -- Option and Asset Purchase Agreement, dated July 8, 1996, by and between PerArdua
                   Investors, L.P. and the Company**                                               
3.1             -- Certificate of Incorporation of Registrant*
3.2             -- Bylaws of Registrant*
4.1             -- Form of Common Stock Certificate**
4.2             -- Form of Stock Purchase Warrant*
4.3             -- Form of Private Placement Subscription Agreement*
4.4             -- Form of Acquisition Transaction Subscription Agreement**
4.5             -- Form of Representative's Warrants*
4.6             -- Form of Warrant Agreement (including form of Redeemable Warrant)**
5.1             -- Opinion of LeClair Ryan, A Professional Corporation**
10.1            -- Option & License Agreement, dated March 28, 1994, by and between PerArdua Investors,
                   L.P. and the University of Southern California**                                    
10.2            -- Stockholders' Agreement, dated July 8, 1996, by and between the Company, the
                   stockholders of the Company, and the limited partners of PerArdua Investors, L.P.**
10.3            -- Research Agreement, dated January 7, 1997, by and between the University of Southern
                   California and the Company*
10.4            -- Consulting Agreement, dated September 30, 1996, by and between the Company and
                   Charles E. McKenna, Ph.D.*
10.5            -- Assignment, Assumption and Consent, dated as of July 31, 1996, by and between
                   PerArdua Investors, L.P., the Company and the University of Southern California*
10.6            -- Form of Consulting Agreement by and between the Company and Schneider Securities,
                   Inc.*
10.7            -- Employment Agreement, dated as of September 3, 1996 by and between the Company
                   and Mary Anthony Gray*
23.1            -- Consent of McGladrey & Pullen, LLP*
23.2            -- Consent of LeClair Ryan, A Professional Corporation (included in Exhibit 5.1 hereto)**
24.1            -- Power of Attorney (see Page II-5)*
27.1            -- Financial Data Schedule*

</TABLE>



- ---------------
 * Filed herewith.

** To be filed by amendment.



                              PERARDUA CORPORATION
                                1,000,000 SHARES
                                 OF COMMON STOCK
                                       AND
                          1,000,000 REDEEMABLE WARRANTS


                             UNDERWRITING AGREEMENT

                                                                          , 1997
   Schneider Securities, Inc.
   1120 Lincoln Street
   Denver, Colorado 80203

   Dear Sirs:

   PerArdua  Corporation . a Missouri  corporation (the "Company"),  proposes to
issue and sell to the  several  Underwriters  named in  Schedule  I hereto  (the
"Underwriters"),  one  million  shares of common  stock of the  Company  and one
million redeemable warrant (the  "Securities").  The Company hereby confirms the
agreement  made by it with  respect to the  purchase  of the  Securities  by the
Underwriter,  which  Securities  are more fully  described  in the  Registration
Statement referred to below.Schneider  Securities,Inc..  . is referred to herein
as the "Underwriter" or the "Representative."

   You have  advised the Company that the  Underwriters  desire to act on a firm
commitment  basis to publicly  offer and sell the Securities for the Company and
that you are  authorized  to execute this  Agreement.  The Company  confirms the
agreement made by it with respect to the  relationship  with the Underwriters as
follows:

1.     Filing  of  Registration   Statement  with  S.E.C.  and  Definitions.   A
Registration  Statement and  Prospectus on Form SB-2 (File No. ) with respect to
the  Securities  has been  carefully and  accurately  prepared by the Company in
conformity with the  requirements of the Securities Act of 1933, as amended (the
"Act"),  and the published rules and regulations  (the "Rules and  Regulations")
thereunder  or under  the  Securities  Exchange  Act of 1934,  as  amended  (the
"Exchange  Act") and has been filed with the Securities and Exchange  Commission
(the "Commission") and such other states that the Underwriter deems necessary in
its  discretion to so file to permit a public  offering and trading  thereunder.
Such  registration  statement,  including  the  prospectus,  Part  II,  and  all
financial  schedules and exhibits thereto,  as amended at the time when it shall
become effective, is herein referred to as the "Registration Statement," and the
prospectus  included  as part of the  Registration  Statement  on file  with the
Commission  that  discloses  all the  information  that  was  omitted  from  the
prospectus  on the  effective  date  pursuant  to Rule  430 A of the  Rules  and
Regulations  with  any  changes  contained  in any  prospectus  filed  with  the
Commission by the Company with the Underwriters consent after the effective date
of the Registration  Statement, is herein referred to as the "Final Prospectus."
The prospectus included as part of the Registration Statement of the Company and
in any  amendments  thereto  prior  to the  effective  date of the  Registration
Statement is referred to herein as a "Preliminary Prospectus."

2.     Discount, Delivery, and Sale of the Securities

   (a) Subject to the terms and conditions of this  Agreement,  and on the basis
of the representations, warranties, and agreements herein contained, the Company
agrees  to sell to,  and the  Underwriters  agree to buy from the  Company  at a
purchase price of $ 4.50 per share and $ .09 per  Redeemable  Warrant before any
underwriter  expense  allowances,  an aggregate  of  1,000,000  shares of Common
Stock, and 1,000,000 Redeemable Warrants on a firm commitment basis the "Initial
Securities"..






   It is understood that the Underwriters  propose to offer the Securities to be
purchased hereunder to the public upon the terms and conditions set forth in the
Registration Statement, after the Registration Statement becomes effective.

   (b) Delivery of the Securities against payment of the purchase price therefor
by  certified  or  official  bank check or checks or wire  transfer  in next-day
funds,  payable to the order of the  Company  shall take place at the offices of
the  clearing  broker for the  Underwriter  at New York City,  within  three (3)
business days after the  Securities are first traded (or such other place as may
be designated by agreement  between you and the Company) at 11:00 A.M., New York
time or such time and date as you and the  Company  may agree  upon in  writing,
such time and date of payment  and  delivery  for the  Securities  being  herein
called the "Initial Closing Date."

   The Company  will make the  certificates  for the shares of Common  Stock and
Redeemable  Warrants to be purchased by the Underwriters  hereunder available to
the Underwriter for inspection and packaging at least two (2) full business days
prior to the Initial Closing Date. The  certificates  shall be in such names and
denominations  as the Underwriter may request to the Company in writing at least
two (2) full business days prior to any Closing Date.

   (c) In addition, subject to the terms and conditions of this Agreement and on
the basis of the  representations,  warranties and agreements  herein contained,
the Company grants an option to the Underwriters to purchase up to an additional
150,000 shares of Common Stock and/or up to 150,000  additional  Warrants as the
case may be ("Option  Securities") at the same terms as the  Underwriters  shall
pay  for the  Initial  Securities  being  sold by the  Company  pursuant  to the
provisions  of Section  2(a) hereof.  This option may be exercised  from time to
time, for the purpose of covering  overallotments,  within  forty-five (45) days
after (i) the effective  date of the  Registration  Statement if the Company has
elected  not to rely on Rule 430A  under the Rules and  Regulations  or (ii) the
date of this  Agreement  if the Company has elected to rely upon Rule 430A under
the Rules and Regulations,  upon written notice by the Underwriter setting forth
the number of Option  Securities as to which the  Underwriter  is exercising the
option and the time and date at which  such  certificates  are to be  delivered.
Such  time and date  shall be  determined  by the  Underwriter  but shall not be
earlier than four (4) nor later than ten (10) full  business days after the date
of the exercise of said option. Nothing herein shall obligate the Underwriter to
make any overallotment.

   (d)  Definitive  certificates  in  negotiable  form for the  Securities to be
purchased by the  Underwriter  hereunder will be delivered at the closing by the
Company  to the  Underwriters  against  payment  of the  purchase  price  by the
Underwriters by certified or bank cashier's  checks or wire transfer in next day
funds payable to the order of the Company.

   (e)  The  information  set  forth  under  "Underwriting"  in any  preliminary
prospectus and Prospectus  relating to the  Securities and the  information  set
forth in the last paragraph on the front cover page, under the last paragraph on
page 2 concerning  stabilization and  over-allotment  by the  Underwriters,  and
(insofar as such information  relates to the Underwriters)  constitutes the only
information  furnished by the Underwriter to the Company for inclusion  therein,
and you  represent and warrant to the Company that the  statements  made therein
are correct.

   (f) On the Initial  Closing  Date,  the  Company  shall issue and sell to the
Representative,  warrants (the "Representative's  Warrants") at a purchase price
of $.001 per Representative's  Warrant,  which shall entitle the holders thereof
to  purchase  an  aggregate  of  100,000  shares  of Common  Stock  and  100,000
Redeemable Warrants. The shares of common stock and redeemable warrants issuable
upon the exercise of the Representative's  Warrants are hereafter referred to as
the "Representative's  Securities" or "Representative's Warrants." The shares of
common stock issuable upon exercise of the redeemable  warrants are  hereinafter
referred to collectively as the "Warrant Shares". The Representative's  Warrants
shall be exercisable for a period of four (4) years commencing one (1) year from
the effective date of the Registration Statement at a price equaling one hundred
thirty percent (130%) of the initial  public  offering price of the  Securities.
The form of  Representative's  Warrant Certificate shall be substantially in the
form  filed  as an  Exhibit  to the  Registration  Statement.  Payment  for  the
Representative's Warrants shall be made on the Initial Closing Date.

3.   Representations and Warranties of the Company.




                                       2




   (a) The Company represents and warrants to you as follows:

   (i) The Company has  prepared and filed with the  Commission  a  registration
statement,  and an  amendment  or  amendments  thereto,  on Form  SB-2  (No.  ),
including any related preliminary prospectus ("Preliminary Prospectus"), for the
registration of the  Securities,  the  Representative's  Warrant and the Warrant
Shares   (sometimes   referred  to  herein   collectively   as  the  "Registered
Securities"),  under the Act,  which  registration  statement  and  amendment or
amendments have been prepared by the Company in conformity with the requirements
of the Act,  and the Rules and  Regulations.  The Company will  promptly  file a
further  amendment  to  said  registration  statement  in  the  form  heretofore
delivered to the Underwriter  and will not file any other  amendment  thereto to
which the  Underwriter  shall have objected  verbally or in writing after having
been furnished with a copy thereof. Except as the context may otherwise require,
such registration statement, as amended, on file with the Commission at the time
the  registration   statement  becomes  effective   (including  the  prospectus,
financial statements, any schedules, exhibits and all other documents filed as a
part thereof or that may be incorporated therein (including,  but not limited to
those  documents  or  information  incorporated  by  reference  therein) and all
information  deemed to be a part  thereof as of such time  pursuant to paragraph
(b) of Rule  430(A) of the Rules and  Regulations),  is  hereinafter  called the
"Registration  Statement,"  and the form of  prospectus  in the form first filed
with the  Commission  pursuant to Rule 424(b) of the Rules and  Regulations,  is
hereinafter called the "Prospectus."

   (ii) Neither the Commission nor any state regulatory authority has issued any
order  preventing or suspending  the use of any  Prospectus or the  Registration
Statement and no proceeding  for an order  suspending the  effectiveness  of the
Registration Statement or any of the Company's securities has been instituted or
is pending or threatened. Each such Prospectus and/or any supplement thereto has
conformed  in all material  respects  with the  requirements  of the Act and the
Rules and Regulations and on its date did not include any untrue  statement of a
material fact or omit to state a material fact  necessary to make the statements
therein  not  misleading,  in light of the  circumstances  under which they were
made; and when the Prospectus becomes legally effective and for twenty-five (25)
days subsequent  thereto (i) the Prospectus  and/or any supplement  thereto will
contain all  statements  which are required to be stated  therein by the Act and
Rules and  Regulations,  and (ii) the Prospectus  and/or any supplement  thereto
will not include any untrue  statement  of a material  fact or omit to state any
material fact required to be stated  therein or necessary to make the statements
therein  not  misleading,  in light of the  circumstances  under which they were
made; provided,  however, that no representations,  warranties or agreements are
made hereunder as to information  contained in or omitted from the Prospectus in
reliance upon, and in conformity with, the written information  furnished to the
Company by you as set forth in Section 2(e) above.

   (iii)  The Company has been duly  incorporated  and is validly  existing as a
corporation in good standing  under the laws of the state of its  incorporation,
with full power and authority  (corporate  and other) to own its  properties and
conduct its  businesses as described in the  Prospectus and is duly qualified to
do business as a foreign corporation in good standing in all other jurisdictions
in which  the  nature  of its  business  or the  character  or  location  of its
properties requires such  qualification,  except where the failure to so qualify
would  not  have a  material  adverse  effect  on the  business,  properties  or
operations of the Company and the subsidiaries as a whole.

    (iv) The Company has full legal right,  power and  authority  to  authorize,
issue,  deliver  and  sell  the  Securities,   the  Option  Securities  and  the
Representative's   Securities   and  to   enter   into   this   Agreement,   the
Representative's  Warrant  dated as of the initial  closing date to be exercised
and  delivered  by the  Company  to the  Representative  (the  "Representative's
Warrant Agreement"), and the Financial Advisory and Investment Banking Agreement
dated as of the Initial Closing Date between the Company and the  Representative
(the "Consulting Agreement"), and to consummate the transactions provided for in
such  agreements,  and  each of such  agreements  has  been  duly  and  properly
authorized,  and on the Initial Closing Date will be duly and properly  executed
and  delivered by the Company.  This  Agreement  constitutes  and on the Initial
Closing Date each of the  Representative's  Warrant Agreement and the Consulting
Agreement  will then  constitute  valid and binding  agreements,  enforceable in
accordance with their respective terms (except as the enforceability thereof may
be limited by bankruptcy or other similar laws affecting the rights of creditors
generally or by general  equitable  principles and except as the  enforcement of
indemnification provisions may be limited by federal or state securities laws).




                                       3




   (v) Except as disclosed in the Prospectus, the Company is not in violation of
its respective  certificate or articles of incorporation or bylaws or in default
in the performance or observance of any material obligation, agreement, covenant
or condition contained in any material bond,  debenture,  note or other evidence
of  indebtedness  or  in  any  material  contract,  indenture,   mortgage,  loan
agreement, lease, joint venture, partnership or other agreement or instrument to
which the  Company is a party or by which it may be bound or is not in  material
violation of any law, order, rule, regulation, writ, injunction or decree of any
governmental  instrumentality or court,  domestic or foreign;  and the execution
and delivery of this Agreement,  the Representative's  Warrant Agreement and the
Consulting  Agreement,  and the  consummation of the  transactions  contemplated
therein  and in the  Prospectus  and  compliance  with the  terms  of each  such
agreement will not conflict  with, or result in a material  breach of any of the
terms,  conditions or provisions of, or constitute a material  default under, or
result in the imposition of any material lien, charge or encumbrance upon any of
the property or assets of the Company pursuant to, any material bond, debenture,
note or other  evidence of  indebtedness  or any material  contract,  indenture,
mortgage, loan agreement,  lease, joint venture,  partnership or other agreement
or instrument to which the Company is a party nor will such action result in the
material  violation by the Company of any of the  provisions  of its  respective
certificate  or articles of  incorporation  or bylaws or any law,  order,  rule,
regulation,   writ,   injunction,   decree  of  any   government,   governmental
instrumentality or court, domestic or foreign,  except where such violation will
not have a material adverse effect on the financial condition of the Company.

   (vi) The authorized,  issued and outstanding  capital stock of the Company is
as  set  forth  in the  Prospectus  and  the  Company  will  have  the  adjusted
capitalization  set forth therein on the Initial Closing Date; all of the shares
of issued and  outstanding  capital  stock of the Company set forth therein have
been duly authorized,  validly issued and are fully paid and nonassessable;  the
holders thereof do not have any rights of rescission  with respect  therefor and
are not  subject to personal  liability  for any  obligations  of the Company by
reason of being stockholders under the laws of the State in which the Company is
incorporated; none of such outstanding capital stock is subject to or was issued
in violation  of any  preemptive  or similar  rights of any  stockholder  of the
Company; and such capital stock (including the Securities, the Option Securities
and the  Representative's  Securities)  conforms in all material respects to all
statements relating thereto contained in the Prospectus.

   (vii)  The Company is not a party to or bound by any instrument, agreement or
other arrangement providing for it to issue any capital stock, rights, warrants,
options or other  securities,  except for this  Agreement or as described in the
Prospectus.  The  Securities,  the Option  Securities  and the  Representative's
Securities  are not and will not be subject to any  preemptive  or other similar
rights of any stockholder,  have been duly authorized and, when issued, paid for
and delivered in accordance with the terms hereof, will be validly issued, fully
paid and non-assessable and will conform to the respective  descriptions thereof
contained in the Prospectus; except for payment of the applicable purchase price
paid upon  exercise of the options or  warrants,  as the case may be the holders
thereof  will not be  subject  to any  liability  solely  as such  holders;  all
corporate action required to be taken for the  authorization,  issue and sale of
the Securities,  the Option Securities and the  Representative's  Securities has
been duly and validly taken; and the  certificates  representing the Securities,
the Option  Securities and the  Representative's  Securities  will be in due and
proper form. Upon the issuance and delivery  pursuant to the terms hereof of the
Securities, the Option Securities and the Representative's Securities to be sold
by the Company hereunder, the Underwriter will acquire good and marketable title
to such Securities,  Option Securities and Representative's  Securities free and
clear of any lien, charge, claim, encumbrance, pledge, security interest, defect
or other  restriction of any kind whatsoever  other than  restrictions as may be
imposed under the securities laws.

   (viii) The Company has good and marketable title to all properties and assets
described  in the  Prospectus  as owned  by it,  free  and  clear of all  liens,
charges, encumbrances or restrictions,  except such as are described or referred
to in the  Prospectus or which are not  materially  significant  or important in
relation to its business or which have been  incurred in the ordinary  course of
business;  except as described in the Prospectus all of the leases and subleases
under which the Company  holds  properties  or assets as lessee or  sublessee as
described in the Prospectus are in full force and effect, and the Company is not
in material  default in respect of any of the terms or provisions of any of such
leases or  subleases,  and no claim has been  asserted by anyone  adverse to the
Company's  rights as lessor,  sublessor,  lessee or  sublessee  under any of the
leases or subleases  mentioned  above or affecting or questioning  the Company's
right to the continued  possession of the leased or subleased premises or assets
under any such  lease or  sublease;  and 




                                       4




the  Company  owns  or  leases  all  such  properties  as are  necessary  to its
operations  as now  conducted and as  contemplated  to be  conducted,  except as
otherwise stated in the Prospectus.

   (ix)  The financial statements, together with related notes, set forth in the
Prospectus  fairly  present the financial  position and results of operations of
the Company at the respective dates and for the respective periods to which they
apply.  Said  statements and related notes have been prepared in accordance with
generally accepted accounting  principles applied on a basis which is consistent
in all material respects during the periods involved but any stub period has not
been  audited by an  independent  accounting  firm.  There has been no  material
adverse  change or material  development  involving a prospective  change in the
condition,  financial  or  otherwise,  or in the  prospects,  value,  operation,
properties,  business or results of  operations  of the  Company  whether or not
arising in the  ordinary  course of  business,  since the date of the  financial
statements included in the Registration Statement and the Prospectus.

   (x)  Subsequent to the respective  dates as of which  information is given in
the Prospectus as it may be amended or supplemented,  and except as described in
the  Prospectus,  the Company  has not,  directly or  indirectly,  incurred  any
liabilities or obligations,  direct or contingent, not in the ordinary course of
business  or  entered  into  any  transactions  not in the  ordinary  course  of
business, which are material to the business of the Company as a whole and there
has not been any change in the capital stock of, or any  incurrence of long term
debts by, the Company or any issuance of options, warrants or rights to purchase
the capital  stock of the Company or  declaration  or payment of any dividend on
the capital stock of the Company or any material adverse change in the condition
(financial  or other),  net worth or results of  operations  of the Company as a
whole and the Company has not become a party to, any material litigation whether
or not in the ordinary course of business.

   (xi) To the  knowledge  of the  Company,  there is no pending or  threatened,
action,  suit or  proceeding  to which the  Company is a party  before or by any
court or governmental agency or body, which might result in any material adverse
change in the  condition  (financial  or other),  business or  prospects  of the
Company as a whole or might  materially  and adversely  affect the properties or
assets of the Company as a whole nor are there any actions, suits or proceedings
against   the   Company   related  to   environmental   matters  or  related  to
discrimination  on the  basis  of age,  sex,  religion  or race  which  might be
expected  to  materially  and  adversely  affect the  conduct  of the  business,
property, operations, financial condition or earnings of the Company as a whole;
and no labor disturbance by the employees of the Company  individually exists or
is, to the  knowledge  of the  Company,  imminent  which  might be  expected  to
materially  and  adversely  affect  the  conduct  of  the  business,   property,
operations, financial condition or earnings of the Company as a whole.

   (xii) Except as may be disclosed in the Prospectus,  the Company has properly
prepared and filed all necessary  federal,  state,  local and foreign income and
franchise tax returns,  has paid all taxes shown as due thereon, has established
adequate reserves for such taxes which are not yet due and payable, and does not
have any tax deficiency or claims outstanding, proposed or assessed against it.

   (xiii) The Company has sufficient  licenses,  permits,  right to use trade or
service marks and other governmental  authorizations  currently required for the
conduct  of its  business  as now  being  conducted  and as  contemplated  to be
conducted  and the  Company is in all  material  respects  complying  therewith.
Except as set forth in the  Prospectus,  the  expiration  of any such  licenses,
permits,  or other governmental  authorizations  would not materially affect the
Company's operations.  To its knowledge, none of the activities or businesses of
the  Company are in material  violation  of, or cause the Company to  materially
violate any law, rule,  regulations,  or order of the United States,  any state,
county or  locality,  or of any  agency or body of the  United  States or of any
state, county or locality.

   (xiv)  The  Company  has not at any time (i)  made any  contributions  to any
candidate for political  office in violation of law, or failed to disclose fully
any such contribution, or (ii) made any payment to any state, federal or foreign
governmental officer or official, or other person charged with similar public or
quasipublic duties, other than payments required or allowed by applicable law.




                                        5




       (xv)  Except  as set  forth in the  Prospectus  the  Company  knows of no
outstanding  claims  for  services  either  in the  nature  of a  finder's  fee,
brokerage fee or otherwise  with respect to this financing for which the Company
or the  Underwriters may be responsible,  or which may affect the  Underwriter's
compensation  as determined by the National  Association of Securities  Dealers,
Inc.  ("NASD")  except as otherwise  disclosed in the Prospectus or known by the
Underwriters.

       (xvi) The Company has its  property  adequately  insured  against loss or
damage by fire and maintains such other  insurance as is customarily  maintained
by companies in the same or similar business.

       (xvii)  The  Representative's  Warrants  herein  described  are  duly and
validly  authorized  and  upon  delivery  to the  Representative  in  accordance
herewith  will be duly issued and legal,  valid and binding  obligations  of the
Company,  except as the  enforceability  thereof may be limited by bankruptcy or
other similar laws  affecting the rights of creditors  generally or by equitable
principles,  and except as the enforcement of indemnification  provisions may be
limited by federal or state securities laws.

                  The Representative's  Securities issuable upon exercise of any
of the Representative's Warrants have been duly authorized, and when issued upon
payment of the exercise price therefor,  will be validly issued,  fully paid and
nonassessable.

       (xviii) Except as set forth in the  Prospectus,  no default exists in the
due  performance  and  observance  of any term,  covenant  or  condition  of any
material license,  contract,  indenture,  mortgage,  installment sale agreement,
lease, deed of trust, voting trust agreement, stockholders agreement, note, loan
or credit  agreement,  purchase  order,  or any other  agreement  or  instrument
evidencing an obligation for borrowed money, or any other material  agreement or
instrument  to which the Company is a party or by which the Company may be bound
or to which the property or assets  (tangible or  intangible)  of the Company is
subject or affected.

       (xix) To the best of the Company's  knowledge it has generally  enjoyed a
satisfactory  employer-employee relationship with its employees and, to the best
of its knowledge, is in substantial compliance in all material respects with all
federal,  state, local, and foreign laws and regulations  respecting  employment
and  employment  practices,  terms and  conditions of  employment  and wages and
hours.  To  the  best  of  the  Company's   knowledge,   there  are  no  pending
investigations  involving the Company,  by the U.S.  Department of Labor, or any
other  governmental  agency  responsible  for the  enforcement  of such federal,
state,  local,  or foreign laws and  regulations.  To the best of the  Company's
knowledge,  there is no unfair labor  practice  charge or complaint  against the
Company  pending  before  the  National  Labor  Relations  Board or any  strike,
picketing,  boycott, dispute, slowdown or stoppage pending or threatened against
or to its knowledge  involving the Company,  or any predecessor entity, and none
has ever occurred.  To the best of the Company's  knowledge,  no  representation
question is pending  respecting the employees of the Company,  and no collective
bargaining  agreement or modification  thereof is currently being  negotiated by
the Company. To the best of the Company's knowledge, no grievance or arbitration
proceeding  is  pending  or to its  knowledge  threatened  under any  expired or
existing collective  bargaining agreements of the Company. No labor dispute with
the employees of the Company is pending,  or, to its knowledge is imminent;  and
the  Company is not aware of any pending or imminent  labor  disturbance  by the
employees of any of its principal suppliers,  manufacturers or contractors which
may  result in any  material  adverse  change  in the  condition,  financial  or
otherwise, or in the earnings,  business affairs,  position,  prospects,  value,
operation, properties, business or results of operations of the Company.

       (xx)  Except  as may be set  forth  in the  Registration  Statement,  the
Company does not maintain,  sponsor or contribute to any program or  arrangement
that is an "employee  pension benefit plan," an "employee welfare benefit plan,"
or a  "multiemployer  plan" as such terms are defined in Sections 3(2), 3(l) and
3(37), respectively,  of the Employee Retirement Income Security Act of 1974, as
amended ("ERISA") ("ERISA Plans").  The Company does not maintain or contribute,
now or at any time previously,  to a defined benefit plan, as defined in Section
3(35) of ERISA. No ERISA Plan (or any trust created thereunder) has engaged in a
"prohibited  transaction"  within the meaning of Section 406 of ERISA or Section
4975 of the Internal Revenue Code (the "Code"),  which could subject the Company
to any tax penalty on prohibited  transactions and which has not adequately been
corrected.  Each  ERISA  Plan is in  compliance  with  all  material  reporting,
disclosure  and other  requirements  of the Code and ERISA as





                                        6




they relate to any such ERISA Plan.  Determination  letters  have been  received
from the  Internal  Revenue  Service  with  respect  to each ERISA Plan which is
intended to comply with Code  Section 401 (a),  stating that such ERISA Plan and
the attendant trust are qualified  thereunder.  The Company has never completely
or partially withdrawn from a "multiemployer plan."

       (xxi)  None  of  the  Company,  or  any  of  its  employees,   directors,
stockholders,  or affiliates  (within the meaning of the Rules and  Regulations)
has taken or will take, directly or indirectly,  any action designed to or which
has  constituted  or which might be  expected  to cause or result in,  under the
Exchange Act, or otherwise,  stabilization  or  manipulation of the price of any
security  of the  Company to  facilitate  the sale or resale of the  Securities,
Option Securities, Representative's Securities or otherwise.

       (xxii) None of the  patents,  patent  applications,  trademarks,  service
marks,  trade  names,  copyrights,  and  licenses  and  rights to the  foregoing
presently owned or held by the Company, are in dispute or, to the best knowledge
of the  Company's  management  are in any  conflict  with the right of any other
person or entity.  The Company (i) except as disclosed in the Prospectus owns or
has the right to use, all patents,  trademarks,  service marks,  trade names and
copyrights,  technology  and licenses and rights with respect to the  foregoing,
used in the conduct of its business as now conducted or proposed to be conducted
without  infringing upon or otherwise  acting  adversely to the right or claimed
right of any person, corporation or other entity under or with respect to any of
the foregoing,  and except as set forth in the Prospectus or otherwise disclosed
to the Underwriter in writing, to the best knowledge of the Company's management
is not obligated or under any liability whatsoever to make any material payments
by way of  royalties,  fees or  otherwise  to any owner or licensee of, or other
claimant  to, any  patent,  trademark,  service  mark,  trade  name,  copyright,
know-how,  technology or other intangible asset, with respect to the use thereof
or in connection with the conduct of its business or otherwise.

       (xxiii)  Except as disclosed in the  Prospectus  the Company owns and has
adequate  right to use to the best  knowledge of the  Company's  management  all
trade secrets,  know-how  (including all other  unpatented  and/or  unpatentable
proprietary or confidential  information,  systems or  procedures),  inventions,
designs,  processes,  works of authorship,  computer programs and technical data
and information  (collectively herein  "intellectual  property") required for or
incident to the development, manufacture, operation and sale of all products and
services sold or proposed to be sold by the Company. The Company is not aware of
any such  development  of  similar  or  identical  trade  secrets  or  technical
information  by  others.  The  Company  has  valid and  binding  confidentiality
agreements with all of its officers, covering its intellectual property (subject
to the equitable powers of any court),  which agreements have remaining terms of
at least two years from the effective date of the Registration  Statement except
where the failure to have such  agreements  would not  materially  and adversely
effect  the  Company's  business  taken as a  whole.  The  Company  has good and
marketable title to, or valid and enforceable leasehold estates in, all items of
real and personal property stated in the Prospectus, to be owned or leased by it
free and clear of all liens, charges, claims,  encumbrances,  pledges,  security
interests,  defects,  or other  restrictions or equities of any kind whatsoever,
other than those  referred to in the  Prospectus and liens for taxes not yet due
and payable.

       (xxiv)  McGladrey  & Pullen,  LLP.,  whose  reports  are  filed  with the
Commission as a part of the Registration  Statement,  are independent  certified
public accountants as required by the Act and the Rules and Regulations.

       (xxv) The  Company  has agreed to execute  and has also caused to be duly
executed  agreements  pursuant  to  which  each of the  Company's  officers  and
directors and shareholders and any person or entity deemed to be an affiliate of
the Company pursuant to the Rules and Regulations has agreed not to, directly or
indirectly, sell, assign, transfer, or otherwise dispose of any shares of Common
Stock  or  securities  convertible  into,  exercisable  or  exchangeable  for or
evidencing  any right to purchase or  subscribe  for any shares of Common  Stock
(either  pursuant to Rule 144 of the Rules and  Regulations  or otherwise) for a
period of not less than  thirteen  (13) months  following  such  effective  date
without the prior written consent of the Underwriter. The Company will cause the
Transfer Agent,  as defined below, to mark an appropriate  legend on the face of
stock  certificates  representing  all of such  securities  and to  place  "stop
transfer" orders on the Company's stock ledgers.




                                       7




       (xxvi) The Registered Securities have been approved for listing on NASDAQ
or an Exchange.

       (xxvii)  Except as set forth in the Prospectus or disclosed in writing to
the Underwriter (which writing specifically refers to this Section),  no officer
or director of the Company, holder of 5% or more of securities of the Company or
any  "affiliate"  or  "associate"  (as  these  terms  are  defined  in Rule  405
promulgated  under the Rules and Regulations) of any of the foregoing persons or
entities has or has had, either  directly or indirectly,  (i) an interest in any
person or entity  which (A)  furnishes or sells  services or products  which are
furnished or sold or are proposed to be furnished or sold by the Company, or (B)
purchases  from or sells or furnishes  to the Company any goods or services,  or
(ii) a beneficiary interest in any contract or agreement to which the Company is
a party or by which it may be bound  or  affected.  Except  as set  forth in the
Prospectus  under  "Certain   Transactions"  or  disclosed  in  writing  to  the
Underwriter  (which  writing  specifically  refers to this Section) there are no
existing agreements,  arrangements,  understandings or transactions, or proposed
agreements,  arrangements,  understandings or transactions, between or among the
Company, and any officer, director, principal stockholder of the Company, or any
partner, affiliate or associate of any of the foregoing persons or entities.

       (xxviii)  Any  certificate  signed by any  officer  of the  Company,  and
delivered to the Underwriter or to the Underwriter's counsel (as defined herein)
shall be deemed a representation  and warranty by the Company to the Underwriter
as to the matters covered thereby.

       (xxix) Each of the minute books of the Company has been made available to
the Underwriter  and contains a complete  summary of all meetings and actions of
the  directors  and  stockholders  of  the  Company,   since  the  time  of  its
incorporation  and  reflect  all  transactions   referred  to  in  such  minutes
accurately in all respects.

       (xxx)As of the Initial  Closing  Date,  the  Company  will enter into the
Consulting  Agreement  substantially  in the  form  filed as an  Exhibit  to the
Registration  Statement with respect to the rendering of consulting  services by
the Representative to the Company.

       (xxxi)  Except  and only to the extent  described  in the  Prospectus  or
disclosed in writing to the Underwriter  (which writing  specifically  refers to
this  Section),  no holders of any  securities of the Company or of any options,
warrants or other convertible or exchangeable securities of the Company have the
right to  include  any  securities  issued by the  Company  in the  Registration
Statement or any registration statement to be filed by the Company or to require
the  Company  to file a  registration  statement  under the Act and no person or
entity  holds any  anti-dilution  rights with respect to any  securities  of the
Company.  Except as  disclosed  in the  Prospectus,  all rights so  described or
disclosed  have  been  waived or have not been  triggered  with  respect  to the
transactions  contemplated by this Agreement,  the Consulting  Agreement and the
Representative's Warrant Agreement (including the warrants issuable thereunder).

       (xxxii) The Company has not entered into any employment  agreements  with
its executive officers, except as disclosed in the Prospectus.

       (xxxiii) No consent,  approval,  authorization or order of, and no filing
with, any court,  regulatory body,  government agency or other body, domestic or
foreign,  is required for the issuance of the Registered  Securities pursuant to
the Prospectus and the Registration Statement, the issuance of the Underwriter's
Warrants,  the  performance  of this  Agreement,  the  Representative's  Warrant
Agreement and the Consulting Agreement, and the transactions contemplated hereby
and thereby, including without limitation,  any waiver of any preemptive,  first
refusal or other  rights that any entity or person may have for the issue and/or
sale of any of the  Securities,  the  Option  Securities  and the  Underwriter's
Securities, except such as have been or may be obtained under the Act, otherwise
or may be required  under state  securities or blue sky laws in connection  with
the  Underwriter's  purchase  and  distribution  of the  Securities,  the Option
Securities, the Representative's Securities and the Underwriter's Warrants to be
sold by the Company  hereunder  or may be required by the Rules of the  National
Association of Securities Dealer, Inc. ("NASD").




                                       8




   (xxxiv) All executed  agreements,  contracts or other  documents or copies of
executed  agreements,  contracts  or other  documents  filed as  exhibits to the
Registration  Statement  to which the  Company  is a party or by which it may be
bound or to which its assets,  properties or businesses may be subject have been
duly  and  validly  authorized,  executed  and  delivered  by  the  Company  and
constitute the legal, valid and binding  agreements of the Company,  enforceable
against the Company, in accordance with their respective terms. The descriptions
in the Registration  Statement of agreements,  contracts and other documents are
accurate and fairly  present the  information  required to be shown with respect
thereto by Form SB-2,  and there are no contracts or other  documents  which are
required by the Act to be  described in the  Registration  Statement or filed as
exhibits  to the  Registration  Statement  which are not  described  or filed as
required, and the exhibits which have been filed are complete and correct copies
of the documents of which they purport to be copies.

   (xxxv)  Within the past five (5)  years,  none of the  Company's  independent
public accountants has brought to the attention of the Company's  management any
"material  weakness" as defined in the Statement of Auditing  Standard No. 60 in
any of the Company's internal controls.

4.    Covenants of the Company.  The Company covenants and agrees with you that:

   (a) It will cooperate in all respects in making the Prospectus  effective and
will not at any  time,  whether  before or after the  effective  date,  file any
amendment to or supplement to the  Prospectus of which you shall not  previously
have been  advised  and  furnished  with a copy or to which you or your  counsel
shall have reasonably  objected or which is not in material  compliance with the
Act and the Rules and Regulations or applicable state law.

   As soon as the Company is advised  thereof,  the Company will advise you, and
confirm the advice in writing,  of the receipt of any comments of the Commission
or any state  securities  department,  when the Registration  Statement  becomes
effective  if the  provisions  of Rule  430A  promulgated  under the Act will be
relied upon,  when the  Prospectus  has been filed in accordance  with said Rule
430A, of the  effectiveness of any  posteffective  amendment to the Registration
Statement or  Prospectus,  or the filing of any  supplement to the Prospectus or
any amended  Prospectus,  of any  request  made by the  Commission  or any state
securities  department for amendment of the Prospectus or for  supplementing  of
the  Prospectus  or for  additional  information  with respect  thereto,  of the
issuance of any stop order suspending the effectiveness of the Prospectus or any
order preventing or suspending the use of any Prospectus or any order suspending
trading  in the  Common  Stock  of the  Company,  or of  the  suspension  of the
qualification of the Securities,  the Option  Securities or the  Representatives
Securities  for  offering  in any  jurisdiction,  or of the  institution  of any
proceedings for any such purposes,  and will use its best efforts to prevent the
issuance  of any such order and, if issued,  to obtain as soon as  possible  the
lifting or dismissal thereof.

The Company has caused to be delivered to you copies of such Prospectus, and the
Company  has  consented  and hereby  consents  to the use of such copies for the
purposes permitted by law. The Company authorizes you and the dealers to use the
Prospectus and such copies of the Prospectus in connection  with the sale of the
Securities,  the Option Securities and the Representative's  Securities for such
period as in the  opinion of your  counsel  and our  counsel  the use thereof is
required to comply with the  applicable  provisions of the Act and the Rules and
Regulations.  The Company will prepare and file with the states,  promptly  upon
your request, any such amendments or supplements to the Prospectus, and take any
other action, as, in the opinion of your counsel,  may be necessary or advisable
in connection with the initial sale of the Securities, the Option Securities and
the Underwriter's  Securities and will use its best efforts to cause the same to
become effective as promptly as possible.




   The Company shall file the Prospectus (in form and substance  satisfactory to
the Underwriter) or transmit the Prospectus by a means reasonably  calculated to
result in filing with the  Commission  pursuant to rule 424(b)(1) or pursuant to
Rule 424(b)(3) not later than the Commission's  close of business on the earlier
of (i) the second  business day  following  the  execution  and delivery of this
Agreement,  and (ii) the fifth  business  day after  the  effective  date of the
Registration Statement.




                                       9




   In case of the  happening,  at any time within such period as a Prospectus is
required  under the Act to be delivered in  connection  with the initial sale of
the Securities, the Option Securities and the Representative's Securities of any
event of which the  Company  has  knowledge  and which  materially  affects  the
Company,  or the  securities  thereof,  and  which  should  be set  forth  in an
amendment of or a supplement to the  Prospectus in order to make the  statements
therein not then misleading,  in light of the circumstances existing at the time
the Prospectus is required under the Act to be delivered, or in case it shall be
necessary  to amend or  supplement  the  Prospectus  to comply with the Act, the
Rules and  Regulations or any other law, the Company will forthwith  prepare and
furnish to you copies of such amended  Prospectus  or of such  supplement  to be
attached to the Prospectus, in such quantities as you may reasonably request, in
order that the Prospectus,  as so amended or supplemented,  will not contain any
untrue  statement of a material fact or omit to state any material fact required
to be stated therein or necessary to make the statements  therein not misleading
in light of the  circumstances  under which they are made. The  preparation  and
furnishing of any such  amendment or supplement to the  Prospectus or supplement
to be attached to the Prospectus shall be without expense to you.

   The Company will to the best of its ability comply with the Act, the Exchange
Act and applicable  state  securities laws so as to permit the initial offer and
sales  of  the  Securities,   the  Option  Securities  and  the  Representatives
Securities  under the Act,  the  Rules and  Regulations,  and  applicable  state
securities laws.

   (b) It will cooperate to qualify the Securities and the Option Securities and
the  Representative's  Securities for initial sale under the securities  laws of
such  jurisdictions  as you may  designate and will make such  applications  and
furnish  such  information  as may be required  for that  purpose,  provided the
Company shall not be required to qualify as a foreign corporation or a dealer in
securities.  The  Company  will,  from  time to  time,  prepare  and  file  such
statements and reports as are or may be required to continue such  qualification
in effect for so long as the Underwriter may reasonably request.

   (c)  So  long  as  any  of  the  Securities,  the  Option  Securities  or the
Representative's  Securities remain  outstanding in the hands of the public, the
Company,  at its expense,  will annually furnish to its shareholders a report of
its operations to include  financial  statements  audited by independent  public
accountants,  and will furnish to the  Underwriter as soon as practicable  after
the end of each  fiscal  year,  a balance  sheet of the Company as at the end of
such fiscal year, together with statements of operations,  shareholders' equity,
and changes in cash flow of the Company for such fiscal year,  all in reasonable
detail  and  accompanied  by a copy of the  certificate  or  report  thereon  of
independent public accountants.

   (d) It will deliver to you at or before the Initial Closing Date three signed
copies of the  Registration  Statement  including all financial  statements  and
exhibits filed therewith,  whether or not incorporated by reference. The Company
will  deliver  to you,  from  time  to  time  until  the  effective  date of the
Prospectus,  as many copies of the Prospectus as you may reasonably request. The
Company  will  deliver  to you on  the  effective  date  of the  Prospectus  and
thereafter for so long as a Prospectus is required to be delivered under the Act
and the Rules and Regulations as many copies of the  Prospectus,  in final form,
or as  thereafter  amended  or  supplemented,  as you  may  from  time  to  time
reasonably request.

   (e) The Company will apply the net proceeds  from the sale of the  Securities
and the Option  Securities  substantially  in the manner set forth under "Use of
Proceeds" in the Prospectus.  No portion of the proceeds shall be used, directly
or  indirectly,  to acquire any  securities  issued by the Company,  without the
prior written consent of the Underwriter.

   (f) As soon as it is  practicable,  but in any event not later than the first
(lst) day of the fifteenth  (15th) full calendar  month  following the effective
date of the  Registration  Statement,  the Company  will make  available  to its
security  holders and the Underwriter an earnings  statement  (which need not be
audited) covering a period of at least twelve (12) consecutive  months beginning
after the effective date of the Registration Statement,  which shall satisfy the
requirements  of  Section  11(a) of the Act and Rule  158(a)  of the  Rules  and
Regulations.




                                       10




   (g) Non-Accountable Expense Allowance and other Costs and Expenses.
       The Company shall pay to the  Underwriter at each closing date, and to be
deducted from the purchase price for the  Securities and the Option  Securities,
an amount  equal to three  percent  (3%) of the gross  proceeds  received by the
Company  from the  sale of the  Securities  and the  Option  Securities  at such
closing date less in the case of the Initial  Closing  Date,  the sum of $50,000
previously paid by the Company. If the sale of the Securities by the Underwriter
is not consummated for any reason not attributable to the Underwriter, or if (i)
the Company withdraws the Registration Statement from the Commission or does not
proceed  with the  public  offering,  or (ii) the  representations  in Section 3
hereof are not correct or the covenants  cannot be complied with, or (iii) there
has been a materially adverse change in the condition,  prospects or obligations
of the Company or a materially  adverse change in stock market  conditions  from
current conditions, all as determined by the Underwriter, then the Company shall
reimburse  the  Underwriter  for its out of pocket  expenses  including  without
limitation, its legal fees and disbursements all on an accountable basis but not
to exceed $100,000 (less the $50,000 previously paid by the Company), and if any
excess remains from the advance previously paid, such excess will be returned to
the Company.
       Costs and Expenses.  Subject to the provisions above the Company will pay
all costs and  expenses  incident to the  performance  of this  Agreement by the
Company  including,  but not limited to, the fees and expenses of counsel to the
Company and of the Company's accountants; the costs and expenses incident to the
preparation, printing, filing and distribution under the Act of the Registration
Statement and Prospectus  (including the fee of the  Commission,  any securities
exchange  and the  NASD in  connection  with  the  filing  required  by the NASD
relating to the offering of the Securities  contemplated  hereby); all expenses,
including fees of counsel, which shall be due and payable on the Closing Date in
connection with the  qualification  of the Securities under the state securities
or blue sky laws; the cost of furnishing to you copies of the  Prospectus,  this
Agreement, the cost of printing the certificates representing the Securities and
of  preparing  and   photocopying   the   Underwriting   Agreement  and  related
Underwriting  documents,  the cost of three  underwriter's  bound  volumes,  any
advertising  costs and  expenses,  including  but not  limited to the  Company's
expenses on "road  show"  information  meetings  and  presentations,  prospectus
memorabilia,  issue and  transfer  taxes,  if any. The Company will also pay all
costs and expenses  incident to the  furnishing of any amended  Prospectus of or
any supplement to be attached to the Prospectus.

(h)  As a condition of the closing,  the Company shall obtain from its officers,
     directors and  shareholders , written  commitments  restricting the sale of
     100% of the common  shares of stock  outstanding  for (13) months after the
     effective date . The Company will not,  without the  underwriters  consent,
     which will not be unreasonably  withheld , sell or offer to sell any shares
     of  common  stock or other  equity  securities  for (13)  months  after the
     closing of the offering, except in connection with acquisitions or pursuant
     to warrants and options immediately outstanding prior to the closing.

    (i) During a  date five years after the date  hereof,  the Company will make
available  to its  shareholders,  as soon as  practicable,  and  deliver  to the
Underwriter:

        (1) as soon as they are available,  copies of all reports  (financial or
    other) mailed to shareholders;

        (2) as soon as they are  available,  copies of all reports and financial
    statements  furnished  to or  filed  with  the  Commission,  the NASD or any
    securities exchange;

        (3) every  press  release  and every  material  news item or  article of
        interest  to the  financial  community  in respect of the Company or its
        affairs  which was prepared and released by or on behalf of the Company;
        and



                                       11




         (4) any  additional  information  of a  public  nature  concerning  the
         Company  (and any  future  subsidiaries)  or its  businesses  which the
         Underwriter may request.

    During such five-year  period, if the Company has active  subsidiaries,  the
foregoing  financial  statements  will be on a consolidated  basis to the extent
that the accounts of the Company and its subsidiaries are consolidated, and will
be accompanied by similar  financial  statements for any significant  subsidiary
which is not so consolidated.

    (j) The Company will maintain a Transfer  Agent and, if necessary  under the
jurisdiction of incorporation of the Company, a Registrar (which may be the same
entity as the Transfer Agent) for its Common Stock.

    (k) The Company  will  furnish to the  Underwriter  or on the  Underwriter's
order, without charge, at such place as the Underwriter may designate, copies of
each Preliminary Prospectus, the Final Prospectus the Registration Statement and
any pre-effective or post-effective amendments thereto (two of which copies will
be  signed  and  will  include  all  financial  statements  and  exhibits),  the
Prospectus, and all amendments and supplements thereto, including any prospectus
prepared after the effective date of the Registration Statement, in each case as
soon as available and in such quantities as the Underwriter may request.

    (1) Neither the Company nor any of its officers, directors,  stockholders or
any of its affiliates will take, directly or indirectly, any action designed to,
or which  might in the  future  reasonably  be  expected  to cause or  result in
stabilization or manipulation of the price of any of the Company's securities.

    (m) The Company shall timely file all such reports, forms or other documents
as may be required (including,  but not limited to, a Form SR as may be required
pursuant  to Rule 463  under the Act)  from  time to time,  under  the Act,  the
Exchange Act, and the Rules and  Regulations,  and all such  reports,  forms and
documents  filed  will  comply  as to form and  substance  with  the  applicable
requirements under the Act, the Exchange Act, and the Rules and Regulations.

    (n) The Company shall cause the  Securities to be listed on the NASDAQ Small
Cap  Market  or on an  exchange  for a period  of five (5)  years  from the date
hereof,  and use its best efforts to maintain the listing of the  Securities  to
the extent they are outstanding.

    (o)  As  soon  as  practicable,   (i)  before  the  effective  date  of  the
Registration  Statement,  file a Form 8-A with the Commission  providing for the
registration  under the Exchange Act of the  Securities and (ii) but in no event
more than 30 days from the effective date of the  Registration  Statement,  take
all  necessary  and  appropriate  actions to be included in Standard  and Poor's
Corporation  Descriptions  and/or  Moody's  OTC  Manual  and  to  continue  such
inclusion  for a period of not less than five  years if the  securities  are not
listed on an exchange.

    (p) Until the completion of the distribution of the Securities,  the Company
shall not without the prior written  consent of the  Underwriter and its counsel
which consent shall not be unreasonably withheld or delayed,  issue, directly or
indirectly,  any  press  release  or  other  communication  or  hold  any  press
conference  with  respect  to the  Company  or its  activities  or the  offering
contemplated hereby, other than trade releases issued in 'the ordinary course of
the  Company's  business  consistent  with past  practices  with  respect to the
Company's operations.

    (q) Until the earlier of (i) five (5) years from the date hereof or (ii) the
sale to the public of the Warrant  Shares,  the Company will not take any action
or actions  which may prevent or  disqualify  the Company's use of Form SB-2 (or
other appropriate form) for the registration under the Act of the Warrant Shares
and the Representative's Securities.

    (r) Commencing  one  year  from  the  effective  date  of  the  registration
        statement,  the Company agrees to pay the  Underwriter a 5% solicitation
        fee for the exercise of the  publicly-held  warrants  such  solicitation
        being subject to applicable SEC and NASD Rules.

    (s) The Company agrees to retain the Underwriter's for a period of 36 months
        at $3000  per  month,  to  continue  the  development  of  interest  and
        sponsorship  in the common shares with such amount being paid in advance
        at the closing.




                                       12



   5.  Conditions  of  the  Underwriter's  Obligations.  The  obligation  of the
Underwriters  to offer and sell the  Securities  and the  Option  Securities  is
subject to the accuracy (as of the date hereof,  and as of the Closing Dates) of
and  compliance  with the  representations  and warranties of the Company to the
performance  by it of  its  agreement  and  obligations  hereunder  and  to  the
following additional conditions:

   (a) The  Registration  Statement  shall  have  become  effective  as and when
cleared by the Commission,  and you shall have received  notice  thereof,  on or
prior to any closing  date no stop order  suspending  the  effectiveness  of the
Prospectus shall have been issued and no proceedings for that or similar purpose
shall have been instituted or shall be pending,  or, to your knowledge or to the
knowledge of the Company,  shall be contemplated by the Commission;  any request
on the  part of the  Commission  for  additional  information  shall  have  been
complied with to the reasonable satisfaction of counsel to the Underwriter;  and
qualification, under the securities laws of such states as you may designate, of
the issue and sale of the Securities  upon the terms and  conditions  herein set
forth or contemplated and containing no provision unacceptable to you shall have
been  secured,  and no stop  order  shall be in  effect  denying  or  suspending
effectiveness of such  qualification  nor shall any stop order  proceedings with
respect thereto be instituted or pending or threatened under such law.

   (b) On any  closing  date and,  with  respect  to the letter  referred  to in
subparagraph (iii), as of the date hereof, you shall have received:

   (i) the opinion, together with such number of signed or photostatic copies of
such opinion as you may reasonably  request,  addressed to you by LeClair Ryan.,
counsel for the Company,  in form and substance  reasonably  satisfactory to the
Underwriter and William M. Prifti, Esq., counsel to the Underwriter,  dated each
such closing date, to the effect that:

   (A)  The  Company  has  been  duly  incorporated  and is a  validly  existing
corporation in good standing under the laws of the  jurisdiction  in which it is
incorporated and has all necessary corporate power and authority to carry on its
business as described in the Prospectus.

   (B) The Company is  qualified  to do business in each  jurisdiction  in which
conducting its business requires such qualification, except where the failure to
be so  qualified  would not have a  material  adverse  effect  on the  Company's
business or assets.

   (C) The Company has the full corporate power and authority to enter into this
Agreement,  the Representative's  Warrant Agreement and the Consulting Agreement
and to consummate the transactions  provided for therein and each such Agreement
has been duly and validly  authorized,  executed  and  delivered by the Company.
Each  of this  Agreement,  the  Consulting  Agreement  and the  Representative's
Warrant Agreement,  assuming due  authorization,  execution and delivery by each
other party  thereto,  constitutes a legal,  valid and binding  agreement of the
Company enforceable against the Company in accordance with its terms, subject to
bankruptcy,  insolvency or similar laws governing the rights of creditors and to
general equitable  principles,  and provided that no opinion need be given as to
the enforceability of any indemnification or contribution  provisions,  and none
of the  Company's  execution  or  delivery  of this  Agreement,  the  Consulting
Agreement or the Representative's  Warrant Agreement,  its performance hereunder
or thereunder,  its  consummation  of the  transactions  contemplated  herein or
therein,  or the  conduct  of its  business  as  described  in the  Registration
Statement, the Prospectus,  and any amendments or supplements thereto, conflicts
with or will conflict  with or results or will result in any material  breach or
violation  of any of  the  terms  or  provisions  of,  or  constitutes  or  will
constitute a material  default under, or result in the creation or imposition of
any material lien, charge, claim, encumbrance, pledge, security interest, defect
or other  restriction  of any kind  whatsoever  upon,  any  property  or  assets
(tangible  or  intangible)  of the  Company  pursuant  to the  terms  of (A) the
articles of  incorporation  or by-laws of the Company,  (B) to the  knowledge of
such counsel,  any material  license,  contract,  indenture,  mortgage,  deed of
trust,  voting trust agreement,  stockholders'  agreement,  note, loan or credit
agreement or any other  agreement or  instrument to which the Company is a party
or by which it is or may be bound, or (C) to the knowledge of such counsel,  any
statute,  judgment, decree, order, rule or regulation applicable to the Company,
whether domestic or foreign.



                                       13




   (D) The Company had authorized and outstanding  capital stock as set forth in
the  Prospectus  under  the  heading  "Capitalization"  as of the date set forth
therein,  and all of such issued and  outstanding  shares of capital  stock have
been duly and  validly  authorized  and  issued,  and to the  knowledge  of such
counsel are fully paid and  nonassessable,  and to the knowledge of such counsel
no stockholder of the Company is entitled to any preemptive  rights to subscribe
for,  or  purchase  shares of the  capital  stock and to the  knowledge  of such
counsel  none of such  securities  were issued in  violation  of the  preemptive
rights of any holders of any securities of the Company.

   (E) To the knowledge of such counsel,  the Company is not a party to or bound
by any instrument,  agreement or other arrangement providing for it to issue any
capital stock, rights,  warrants,  options or other securities,  except for this
Agreement,  the Representative's  Warrant Agreement,  and except as described in
the Prospectus. The Common Stock, the Warrants and the Representative's Warrants
each conforms in all material  respects to the respective  descriptions  thereof
contained  in the  Prospectus.  The  outstanding  shares  of Common  Stock,  the
Redeemable Warrant and the Warrant Stock and the Representative's Warrant Stock,
upon issuance and delivery and payment therefore in the manner described herein,
the Warrant Agreement and the Representative Agreement, as the case may be, will
be, duly authorized, validly issued, fully paid and nonassessable.  There are no
preemptive or other rights to subscribe for or to purchase,  or any  restriction
upon the  voting or  transfer  of, any shares of Common  Stock  pursuant  to the
Company's articles of incorporation,  by-laws,  other governing documents or any
agreement  or other  instrument  known to such counsel to which the Company is a
party or by which it is bound.

   (F) The certificates  representing the Securities comprising the Common Stock
and Redeemable Warrants are in due and proper form and each of the Warrant Stock
and the  Representative's  Warrant has been duly  authorized  and  reserved  for
issuance and when issued and delivered in accordance  with the respective  terms
of the Warrant Agreement and Representative's  Warrant Agreement,  respectively,
will duly and validly issued, fully paid and nonassessable.

   (G) To the  knowledge of such  counsel,  there are no claims,  suits or other
legal  proceedings  pending or  threatened  against  the Company in any court or
before or by any governmental body which might materially affect the business of
the Company or the financial  condition of the Company as a whole, except as set
forth in or contemplated by the Prospectus.

   (H) Based on oral and/or written advice from the staff of the Commission, the
Registration  Statement  has become  effective  and,  to the  knowledge  of such
counsel,  no stop order  suspending  the  effectiveness  of the Prospectus is in
effect and no proceedings for that purpose are pending before, or threatened by,
federal or by a state securities administrator.

   (I) To the  knowledge  of such  counsel,  there are no legal or  governmental
proceedings,  actions,  arbitrations,  investigations,  inquiries  or  the  like
pending  or  threatened  against  the  Company  of a  character  required  to be
disclosed in the  Prospectus  which have not been so  disclosed,  questions  the
validity  of  the  capital  stock  of  the  Company  or  this  Agreement  or the
Representative's  Warrant  Agreement or might  adversely  affect the  condition,
financial or otherwise, or the prospects of the Company or which could adversely
affect  the  Company's  ability  to perform  any of its  obligations  under this
Agreement, or the Representative's Warrant Agreement.

   (J) To such counsel's knowledge, there are no material agreements,  contracts
or other documents known to such counsel  required by the Act to be described in
the  Registration  Statement  and the  Prospectus  and filed as  exhibits to the
Registration  Statement other than those described in the Registration Statement
and the  Prospectus  and  filed  as  exhibits  thereto,  and to  such  counsel's
knowledge  (A) the  exhibits  which  have been filed are  correct  copies of the
documents  of which  they  purport  to be copies;  (B) the  descriptions  in the
Registration  Statement  and the  Prospectus  and any  supplement  or  amendment
thereto of contracts  and other  documents to which the Company is a party or by
which it is bound,  including any document to which the Company is a party or by
which  it is  bound  incorporated  by  reference  into  the  Prospectus  and any
supplement  or amendment  thereto,  are  accurate in all  material  respects and
fairly represent the information required to be shown by Form SB-2.





                                       14



   (K) No consent,  approval,  order or authorization from any regulatory board,
agency  or  instrumentality   having  jurisdiction  over  the  Company,  or  its
properties (other than registration  under the Act or qualification  under state
or foreign  securities  law or approval  by the NASD) is required  for the valid
authorization,  issuance,  sale  and  delivery  of the  Securities,  the  Option
Securities or the Representative's Warrant.

   (L) The statements in the Prospectus under "Risk  Factors-Control by Existing
Stockholders,"   "Management-Limitation   of  Liability"   "Description  of  the
Securities,"  and "Shares  Eligible For Future Sale" have been  reviewed by such
counsel,  and  insofar  as they  refer to  statements  of law,  descriptions  of
statutes,  licenses,  rules or regulations or legal conclusions,  are correct in
all material respects.

   In addition,  such counsel shall state that such counsel has  participated in
conferences  with  officials  and  other  representatives  of the  Company,  the
Representatives,  Underwriters'  Counsel and the  independent  certified  public
accountants  of the  Company,  at which such  conferences  the  contents  of the
Registration  Statement and Prospectus and related matters were  discussed,  and
although they have not certified the accuracy or  completeness of the statements
contained in the Registration  Statement or the Prospectus,  nothing has come to
the  attention of such counsel which leads them to believe that, at the time the
Registration  Statement became effective and at all times subsequent  thereto up
to and on the Closing Date and on any later date on which  Option  Shares are to
be purchased,  the Registration Statement and any amendment or supplement,  when
such documents  became  effective or were filed with the Commission  (other than
the financial  statements  including the notes thereto and supporting  schedules
and other financial and statistical  information derived therefrom,  as to which
such  counsel  need  express no comment)  contained  any untrue  statement  of a
material fact or omitted to state a material fact required to be stated  therein
or necessary to make the statements  therein not  misleading,  or at the Closing
Date or any later date on which the Option  Shares are to be  purchased,  as the
case may be, the Prospectus and any amendment or supplement  thereto (other than
the financial  statements  including  the notes thereto and other  financial and
statistical information derived therefrom, as to which such counsel need express
no comment)  contained  any untrue  statement  of a material  fact or omitted to
state a material fact necessary to make the statements  therein, in the light of
the circumstances under which they were made, not misleading.

   Such opinion shall also cover such other matters incident to the transactions
contemplated  hereby  and  the  offering  Prospectus  as you or  counsel  to the
Underwriter shall reasonably  request.  In rendering such opinion, to the extent
deemed  reasonable  by them,  such  counsel  may rely upon  certificates  of any
officer of the  Company or public  officials  as to matters of fact of which the
maker of such certificate has knowledge.

   (ii) a certificate,  signed by the Chief Executive  Officer and the Principal
Financial or  Accounting  Officer of the Company  dated the Closing Date, to the
effect  that with regard to the  Company,  each of the  conditions  set forth in
Section 5(d) have been satisfied.

   (iii) a  letter,  addressed  to the  Underwriter  and in form  and  substance
satisfactory  to the  Underwriter  in all respects  (including  the  nonmaterial
nature of the changes or  decreases,  if any,  referred to in clause (D) below),
from McGladrey & Pullen, LLP, dated,  respectively,  as of the effective date of
the Registration Statement and as of the Closing Date, as the case may be:

   (A) Confirming that they are independent  public  accountants with respect to
the Company and its consolidated subsidiaries, if any, within the meaning of the
Act and the applicable published Rules and Regulations.

   (B) Stating that, in their opinion, the financial  statements,  related notes
and schedules of the Company and its consolidated subsidiaries, if any, included
in the Registration Statement examined by them comply as to form in all material
respects  with  the  applicable  accounting  requirements  of the  Act  and  the
published Rules and Regulations thereunder.

   (C) Stating  that,  with respect to the period from  November 30, 1996,  to a
specified  date (the  specified  date") not earlier than five (5) business  days
prior to the date of such letter,  they have read the minutes of meetings of the
stockholders  and board of  directors  (and various  committees  thereof) of the
Company and its consolidated



                                       15




subsidiaries,  if any,  for the  period  from  November  30,  1996  through  the
specified  date,  and  made  inquiries  of  officers  of  the  Company  and  its
consolidated  subsidiaries,  if any,  responsible  for financial and  accounting
matters and,  especially as to whether  there was any decrease in sales,  income
before  extraordinary  items or net income as  compared  with the  corresponding
period in the preceding  year; or any change in the capital stock of the Company
or any  change in the  longterm  debt or any  increase  in the  short-term  bank
borrowings or any decrease in net current assets or net assets of the Company or
of any of its consolidated subsidiaries,  if any, and further stating that while
such  procedures  and  inquiries  do  not  constitute  an  examination  made  in
accordance with generally  accepted  auditing  standards,  nothing came to their
attention  which caused them to believe that during the period from November 30,
1996,  through the specified  date there were any decreases as compared with the
corresponding period in the preceding year in sales, income before extraordinary
items or net  income;  or any  change in the  capital  stock of the  Company  or
consolidated  subsidiary,  if any,  or any  change  in the long term debt or any
increase  in  the  short-term  bank  borrowings  (other  than  any  increase  in
short-term bank borrowings in the ordinary course of business) of the Company or
any consolidated  subsidiary,  if any, or any decrease in the net current assets
or net assets of the Company or any consolidated subsidiary, if any; and

   (D)  Stating  that  they  have  carried  out  certain  specified   procedures
(specifically  set  forth  in  such  letter  or  letters)  as  specified  by the
Underwriter  (after  consultations with McGladrey & Pullen, LLP relating to such
procedures),  not  constituting  an  audit,  with  respect  to  certain  tables,
statistics  and  other  financial  data  in  the  Prospectus  specified  by  the
Underwriter  and such  financial  data not included in the  Prospectus  but from
which  information  in the  Prospectus is derived,  and which have been obtained
from the general accounting records of the Company or consolidated subsidiaries,
if any, or from such accounting  records by analysis or computation,  and having
compared such financial  data with the accounting  records of the Company or the
consolidated  subsidiaries,  if any, stating that they have found such financial
data to agree with the accounting records of the Company.

   (c) All  corporate  proceedings  and other  legal  matters  relating  to this
Agreement,  the Prospectus and other related matters shall be satisfactory to or
approved by counsel to the  Underwriter and you shall have received from LeClair
Ryan, Esq., a law  corporation,  a signed opinion dated as of each closing date,
with  respect  to  the  incorporation  of  the  Company,  the  validity  of  the
Securities,  the form of the  Prospectus,  (other than the financial  statements
together with related notes and other financial and  statistical  data contained
in the Prospectus or omitted therefrom, as to which such counsel need express no
opinion),  the execution of this Agreement and other related  matters as you may
reasonably require.

   (d) At each closing  date,  (i) the  representations  and  warranties  of the
Company  contained in this  Agreement  shall be true and correct in all material
respects  with the same effect as if made on and as of such closing  date;  (ii)
the  Prospectus  and any  amendments  or  supplements  thereto shall contain all
statements  which are required to be stated  therein in accordance  with the Act
and the  Rules and  Regulations  and in all  material  respects  conform  to the
requirements thereof, and neither the Prospectus nor any amendment or supplement
thereto shall  contain any untrue  statement of a material fact or omit to state
any material  fact required to be stated  therein or necessary,  in light of the
circumstances  under  which  they  were  made,  in order to make the  statements
therein not misleading;  (iii) there shall have been since the respective  dates
as of which  information  is given no material  adverse  change in the business,
properties or condition (financial or otherwise), results of operations, capital
stock,  longterm  debt or general  affairs of the Company from that set forth in
the Prospectus,  except changes which the Prospectus indicates might occur after
the effective  date of the  Prospectus,  and the Company shall not have incurred
any material  liabilities  or material  obligations,  direct or  contingent,  or
entered into any material transaction, contract or agreement not in the ordinary
course of business  other than as referred to in the  Prospectus and which would
be required to be set forth in the  Prospectus;  and (iv) except as set forth in
the  Prospectus,  no action,  suit or  proceeding  at law or in equity  shall be
pending or  threatened  against  the  Company  which would be required to be set
forth in the  Prospectus,  and no  proceedings  shall be pending  or  threatened
against  the Company or any  subsidiary  before or by any  commission,  board or
administrative agency in the United States or elsewhere,  wherein an unfavorable
decision,  ruling or finding would materially and adversely affect the business,
property,  condition (financial or otherwise),  results of operations or general
affairs of the Company.

       (e) On the Initial  Closing  Date,  the Company  shall have  executed and
delivered  to  the  Underwriter,  (i)  the  Representatives'  Warrant  Agreement
substantially in the form filed as an Exhibit to the  Registration  Statement in
final



                                       16




form   and   substance   satisfactory   to  the   Underwriter,   and   (ii)  the
Representative's  Warrants in such  denominations and to such designees as shall
have been provided to the Company.

   (f) On or before the Initial  Closing Date,  the  Securities  shall have been
duly approved for listing on an exchange or on NASDAQ. .

   (g) On or before the Initial Closing Date, there shall have been delivered to
the Underwriter all of the Lock-up Agreements  required to be delivered pursuant
to  Section  3(a)(xxv)  and  4(h),  in form and  substance  satisfactory  to the
Underwriter and Underwriter's counsel.

   If any condition to the Underwriter's  obligations  hereunder to be fulfilled
prior to or at the Closing Date or the relevant Option Closing Date, as the case
may be, is not so fulfilled, the Underwriter may terminate this Agreement or, if
the Underwriter so elects,  it may waive any such conditions which have not been
fulfilled or extend the time for their fulfillment.

6.  Conditions of the Company's  Obligations.  The  obligation of the Company to
sell and deliver the Securities is subject to the following:

   (a) The provisions regarding the effective date, as described in Section 10.

   (b) At the Initial Closing Date, no stop order  suspending the  effectiveness
of the  Prospectus  shall  have been  issued  under  the Act or any  proceedings
therefor  initiated or threatened by the  Commission or by any state  securities
department.

   (c) Tender of payment by the Underwriter in accord with Section 2 hereof.

7. Indemnification.

   (a) The Company  agrees to indemnify and hold harmless each  Underwriter  and
its  employees  and each person,  if any, who controls you within the meaning of
the Act, against any losses,  claims,  damages or liabilities,  joint or several
(which shall,  for any purposes of this Agreement,  include,  but not be limited
to, all costs of defense and  investigation  and all attorneys'  fees), to which
each Underwriter or such controlling person may become subject, under the Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect  thereof) arise out of or are based upon any untrue statement or alleged
untrue  statement  of any material  fact  contained  in the  Prospectus,  or any
amendment or supplement  thereto, or arise out of or are based upon the omission
or alleged  omission made in the Prospectus,  or such amendment or supplement to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein not misleading,  which is in reliance upon and in conformity
with written information furnished by the Company to you specifically for use in
the  preparation  thereof,  and provided  further that the  indemnity  agreement
contained  in this  subsection  (a) shall not inure to the  benefit  of you with
respect to any person  asserting any such loss,  claim,  damage or liability who
has  purchased  the  Securities  which  are the  subject  thereof  if you or any
participants  failed to send or give a copy of the  Prospectus to such person at
or prior to the  written  confirmation  of the sale of such  Securities  to such
person and except that, with respect to any untrue  statement or omission or any
alleged untrue statement or omission, made in any Pre-Effective Prospectus,  the
indemnity  agreement  contained  in this  subsection  (a) shall not inure to the
benefit of any Underwriter ( or to any person  controlling any such underwriter)
from whom the  person  asserting  any such  loss,  claim,  damage  or  liability
purchased the securities  concerned to the extent that such untrue  statement or
omission, or alleged untrue statement or omission, has been corrected in a later
Pre-Effective  Prospectus  or in the Final  Prospectus  unless  the  Underwriter
circulated a later  Pre-Effective  Prospectus  or the Final  Prospectus  to such
person

     (b) Each Underwriter will indemnify and hold harmless the Company,  each of
its  directors,  each of its  officers,  each  person,  if any, who controls the
Company  within the meaning of the Act against  any losses,  claims,  damages or
liabilities,  joint or several (which shall, for all purposes of this Agreement,
include,  but not be limited to, all costs of defense and  investigation and all
attorneys'  fees)  to  which  the  Company  or any  such  director,  officer  or
controlling  person may become  subject under the Act or  otherwise,  insofar as
such losses,  claims,  damages or  liabilities  (or



                                       17




actions in respect  thereof) arise out of or are based upon any untrue statement
or alleged untrue statement of any material fact contained in the Prospectus, or
any  amendment  or  supplement  thereto,  or arise out of or are based  upon the
omission or the alleged omission to state therein a material fact required to be
stated therein or necessary to make the statements  therein not  misleading,  in
each case to the extent,  but only to the extent,  that such untrue statement or
alleged  untrue  statement  or  omission  was  made in the  Prospectus,  or such
amendment  or  supplement,  in  reliance  upon and in  conformity  with  written
information  furnished  to  the  Company  by  you  specifically  for  use in the
preparation  thereof.  This indemnity will be in addition to any liability which
any Underwriter may otherwise have.

   (c)  Promptly  after  receipt by an  indemnified  party under this Section of
notice of the  commencement  of any action,  such  indemnified  party will, if a
claim in respect thereof is to be made against the indemnifying party under this
Section,  notify the  indemnifying  party of the commencement  thereof,  but the
omission  so to notify  the  indemnifying  party  will not  relieve  it from any
liability which it may have to any  indemnified  party otherwise than under this
Section.  In case any such action is brought against any indemnified  party, and
it notifies the indemnifying party of the commencement thereof, the indemnifying
party will be entitled to  participate  in, and, to the extent that it may wish,
jointly with any other indemnifying  party,  similarly  notified,  to assume the
defense  thereof,   subject  to  the  provisions  herein  stated,  with  counsel
satisfactory to such  indemnified  party, and after notice from the indemnifying
party to such  indemnified  party  of its  election  so to  assume  the  defense
thereof,  the indemnifying  party will not be liable to such  indemnified  party
under this Section for any legal or other expenses subsequently incurred by such
indemnified  party in connection  with the defense thereof other than reasonable
costs of  investigation.  The  indemnified  party shall have the right to employ
separate  counsel in any such action and to participate in the defense  thereof,
but the fees and  expenses  of such  counsel  shall not be at the expense of the
indemnifying  party if the  indemnifying  party has  assumed  the defense of the
action with counsel reasonably  satisfactory to the indemnified party;  provided
that, if the indemnified party is you or a person who controls you, the fees and
expenses of such counsel  shall be at the expense of the  indemnifying  party if
(i) the employment of such counsel has been  specifically  authorized in writing
by the  indemnifying  party  or  (ii)  the  named  parties  to any  such  action
(including any impleaded  parties) include both you or such  controlling  person
and the indemnifying  party and you or such  controlling  person shall have been
advised by such counsel that there is a conflict of interest which would prevent
counsel for the indemnifying  party from representing the indemnifying party and
you or such controlling  person (in which case the indemnifying  party shall not
have the right to assume  the  defense  of such  action on behalf of you or such
controlling  person, it being understood,  however,  that the indemnifying party
shall not, in connection with any one such action or separate but  substantially
similar or related actions in the same  jurisdiction  or which are  consolidated
into the  same  jurisdiction  arising  out of the same  general  allegations  or
circumstances,  be liable for the reasonable  fees and expenses of more than one
separate firm of attorneys for you and all such controlling persons,  which firm
shall be designated  in writing by you). No settlement of any action  against an
indemnified  party shall be made without the consent of the  indemnified  party,
which shall not be  unreasonably  withheld in light of all factors of importance
to such indemnified party.

    8.  Contribution.  In order to provide for just and  equitable  contribution
tinder the Act in any case in which (i) the indemnifying party makes a claim for
indemnification pursuant to Section 7 hereof but it is judicially determined (by
the entry of a final judgment or decree by a court of competent jurisdiction and
the expiration of time to appeal or the denial of the last right of appeal) that
such  indemnification may not be enforced in such case  notwithstanding the fact
that the express  provisions  of Section 7 provide for  indemnification  in such
case,  or (ii)  contribution  under the Act may be  required  on the part of the
Underwriters,  then the  Company and the  Underwriters  in the  aggregate  shall
contribute to the aggregate  losses,  claims,  damages,  or liabilities to which
they may be subject (which shall,  for all purposes of this Agreement,  include,
but not be limited to, all costs of defense and investigation and all attorneys'
fees) in either such case (after  contribution  from others) in such proportions
that the  Underwriters are responsible in the aggregate for that portion of such
losses,  claims,  damages or  liabilities  determined by  multiplying  the total
amount of such  losses,  claims,  damages or  liabilities  times the  difference
between the public  offering  price and the  commission to the  Underwriter  and
dividing the product thereof by the public offering price,  and the Company,  if
applicable,  shall be  responsible  for that  portion  of such  losses,  claims,
damages or liabilities times the commission to the Underwriters and dividing the
product  thereof by the  public  offering  price;  provided,  however,  that the
Underwriters  shall not be required to so contribute any amount in excess of the
underwriting discount applicable to the Securities purchased by the Underwriters
hereunder if such  allocation  is not  permitted  by  applicable  law,  then the
relative  fault of the  Company  and the  Underwriters  in  connection  with the
statements  or  omissions  which  resulted in




                                       18




such  damages  and  other  relevant  equitable   considerations  shall  also  be
considered.  No person  guilty of a  fraudulent  misrepresentation  (within  the
meaning of Section 12(2) of the Act) shall be entitled to contribution  from any
person who is not guilty of such  fraudulent  misrepresentation.  The  foregoing
contribution  agreement shall in no way affect the  contribution  liabilities of
any person having  liability  under Section 12 of the Act other than the Company
and the Underwriter. As used in this paragraph, the term "Underwriters" includes
any person who controls the Underwriters within the meaning of Section 15 of the
Act. If the full amount of the  contribution  specified in this paragraph is not
permitted  by law,  then  any  Underwriter  and each  person  who  controls  any
Underwriter  shall be entitled to  contribution  from the  Company,  to the full
extent permitted by law.


   9. Effective Date.  This Agreement  shall become  effective at 10:00 a.m. New
York time on the next full  business day  following  the  effective  date of the
Registration  Statement,  or at such other time after the effective  date of the
Prospectus as you in your discretion shall first commence the public offering of
any of the Securities covered thereby, provided,  however, that at all times the
provisions of Sections 7, 8, 9 and 11 shall be effective.

   10. Termination.

         (a) This Agreement,  may be terminated at any time prior to the Closing
Date by you if in your  judgment  it is  impracticable  to offer  for sale or to
enforce  contracts made by you for the sale of the Securities  agreed to be sold
hereunder  by reason of (i) the Company as a whole  having  sustained a material
loss, whether or not insured, by reason of fire, earthquake,  flood, accident or
other calamity,  or from any labor dispute or court or government action,  order
or decree,  (ii) trading in securities of the Company having been suspended by a
state securities administrator or by the Commission, (iii) material governmental
restrictions  having been  imposed on trading in  securities  generally  (not in
force and effect on the date hereof) or trading on the New York Stock  Exchange,
American  Stock  Exchange,  or in the  over-the-counter  market  shall have been
suspended, (iv) a banking moratorium having been declared by federal or New York
State  authorities,  (v) an  outbreak  or  escalation  of  hostilities  or other
national or  international  calamity  having  occurred,  (vi) the passage by the
Congress of the United  States or by any state  legislative  body, of any act or
measure, or the adoption of any orders, rules or regulations by any governmental
body or any  authoritative  accounting  institute or board, or any  governmental
executive,  which is  believed  likely by you to have a  material  impact on the
business,  financial condition or financial  statements of the Company; or (vii)
any material  adverse change having  occurred,  since the respective dates as of
which  information is given in the  Prospectus,  in the condition,  financial or
otherwise,  of the Company as a whole,  whether or not  arising in the  ordinary
course of  business,  (viii)  .Francis  O'Donnell  .ceases to be employed by the
Company  in his  present  capacity;  (ix) the  Securities  are not listed on any
exchange or on NASDAQ.

         (b) If you elect to prevent this Agreement  from becoming  effective or
to terminate  this Agreement as provided in this Section 10 or in Section 9, the
Company shall be promptly  notified by you, by telephone or telegram,  confirmed
by letter.

   11.  Representations,  Warrants  and  Agreements  to  Survive  Delivery.  The
respective  indemnities,  agreements,  representations,   warranties  and  other
statements of the Company (or its officers) and the  Underwriter set forth in or
made pursuant to this Agreement will remain in full force and effect, regardless
of any investigation  made by or on behalf of the Underwriter,  the Company,  or
any of their officers or directors and will survive  delivery of and payment for
the Securities.

   12.  Notices. All communications  hereunder will be in writing and, except as
        otherwise  expressly  provided  herein,  if sent to you, will be mailed,
        delivered   or   telephoned   and   confirmed   to  you  at,   Schneider
        Securities,Inc.,1120   Lincoln  Street,  Denver,  Colorado  80203  Attn:
        Investment   Banking   Department;   and  to  the  Company  to  PerArdua
        Corporation,  709 The Hamptons  Lane,Town and Country,  Missouri  63017,
        Attn: Francis O'Donnell.




                                       19




   13.  Parties in  Interest.  This  Agreement is made solely for the benefit of
        the Underwriter(s),  and the Company,  and their respective  controlling
        persons,  directors  and  officers,  and  their  respective  successors,
        assigns, executors and administrators.  No other person shall acquire or
        have any right under or by virtue of this Agreement.

   14.  Headings. The Section headings in this Agreement have been inserted as a
matter of convenience of reference and are not a part of this Agreement.

   15.  Applicable  Law.  This  Agreement  shall be governed by and construed in
accordance  with the laws of the State of  Colorado , without  giving  effect to
conflict of law principles.

   16.  Counterparts.   This   Agreement  may  be  executed  in  any  number  of
counterparts,  each  of  which  together  shall  constitute  one  and  the  same
instrument.

    If the foregoing correctly sets forth the understanding  between the Company
and you, as  Representative of the several  underwriters,  please so indicate in
the space  provided  below for such  purpose,  whereupon  this  letter  and your
acceptance shall constitute a binding agreement between us.



                                                 Very truly yours,
                                                 PerArdua Corporation

                                                 By:
                                                    ----------------------------
                                                    (Authorized Officer)
                                                    Francis O'Donnell, President



Accepted as of the date first above written:

Schneider Securities,Inc..
         As Representative of the several Underwriters


By:
   ----------------------------------------
               (Authorized Officer)
                  , (Vice) President









                                   EXHIBIT A


                                   SCHEDULE I

                                  UNDERWRITERS


                                            Shares of
Underwriter                                 Common Stock      Redeemable Warrant
- -----------                                 ------------      ------------------

Schneider Securities,Inc...

                                            ------------      ------------------
TOTAL                                        1,000,000         1,000,000
- -----



                                                                     EXHIBIT 1.2

                                                                       EXHIBIT B

    A REGISTRATION  STATEMENT  RELATING TO THESE  SECURITIES HAS BEEN FILED WITH
THE SECURITIES  AND EXCHANGE  COMMISSION  BUT HAS NOT YET BECOME  EFFECTIVE.  NO
OFFER TO BUY THE  SECURITIES  CAN BE ACCEPTED AND NO PART OF THE PURCHASE  PRICE
CAN BE RECEIVED UNTIL THE REGISTRATION  STATEMENT HAS BECOME EFFECTIVE,  AND ANY
SUCH OFFER MAY BE WITHDRAWN OR REVOKED,  WITHOUT OBLIGATION OR COMMITMENT OF ANY
KIND,  AT ANY TIME PRIOR TO NOTICE OF ITS  ACCEPTANCE  GIVEN AFTER THE EFFECTIVE
DATE. YOUR EXECUTION HEREOF WELL INVOLVE NO OBLIGATION OR COMMITMENT OF ANY KIND
UNTIL THE REGISTRATION STATEMENT HAS BECOME EFFECTIVE.



                              PerArdua Corporation

                           SELECTED DEALERS AGREEMENT
                           --------------------------



                 , 1997
Dear Sirs:

    1. Schneider  Securities,Inc.named as the Underwriter ("Underwriter") in the
enclosed preliminary  Prospectus,  proposes to offer on a firm commitment basis,
subject to the terms and conditions and execution of the Underwriting Agreement,
1,000,000  Shares of Common  Stock at $5.00 per share and  1,000,000  Redeemable
Warrants at $.10 per Warrant ("Securities") of the above Company. The Securities
are  more  particularly  described  in  the  enclosed  preliminary   Prospectus,
additional  copies of which  will be  supplied  in  reasonable  quantities  upon
request.  Copies  of the  definitive  Prospectus  will  be  supplied  after  the
effective date of the Registration Statement.

    2.  The  Underwriter  is  soliciting  offers  to buy,  upon  the  terms  and
conditions hereof, a part of the Securities from Selected Dealers, including you
who are to act as principal and who are (i)  registered  with the Securities and
Exchange  Commission  ("Commission")  as  broker-dealers  under  the  Securities
Exchange Act of 1934, as amended ("1934 Act"), and members in good standing with
the National Association of Securities Dealers,  Inc. ("NASD"),  or (ii) dealers
or  institutions  with their  principal  place of business  located  outside the
United  States,  its  territories  and  possessions  who  are not  eligible  for
membership in the NASD and who agree to make no sales within the United  States,
its  territories  or  possessions  or to persons  who are  nationals  thereof or
residents therein and, in making sales, to comply with the NASD's Interpretation
with Respect to FreeRiding and Withholding and with Sections2730, 2740 and 2420,
to the extent applicable to foreign  nonmember  brokers or DEALERS,  and Section
2750 of the NASD's Rules of Fair Practice. The Securities are to be offered at a
public  price of $ 5.00 per  share of Common  Stock  and  $0.10  per  Redeemable
Warrant.  Selected  Dealers will be allowed a concession  of not less than $ .25
per share and $ .005 per Redeemable Warrant,  except as provided below. You will
be notified of the precise amount of such concession prior to the effective date
of the Registration Statement.  You may reallow not in excess of $ .12 per share
and $.0025 per  Reedeemable  Warrant to dealers  who meet the  requirements  set
forth in this  Section 2. This offer is  solicited  subject to the  issuance and
delivery of the  Securities  and their  acceptance  by the  Underwriter,  to the
approval of legal  matters by counsel and to the terms and  conditions as herein
set forth.

3. Your offer to purchase may be revoked in whole or in part without  obligation
or commitment  of any kind by you and any time prior to acceptance  and no offer
may be  accepted  by us and no sale can be made  until  after  the  registration
statement  covering the  Securities has become  effective  with the  Commission.
Subject to the  foregoing,  upon execution by you of the Offer to Purchase below
and the  return of same to us, you shall be deemed to have





offered  to  purchase  the number of  Securities  set forth in your offer on the
basis set forth in  paragraph 2 above.  Any oral notice by us of  acceptance  of
your offer shall be immediately followed by written or telegraphic  confirmation
preceded or accompanied by a copy of the Prospectus. If a contractual commitment
arises  hereunder,  all the terms of this Selected  Dealers  Agreement  shall be
applicable.  We  may  also  make  available  to  you an  allotment  to  purchase
Securities,  but such allotment  shall be subject to modification or termination
upon notice from us any time prior to an  exchange of  confirmations  reflecting
completed  transactions.  All  references  hereafter  in this  Agreement  to the
purchase and sale of Securities  assume and are  applicable  only if contractual
commitments to purchase are completed in accordance with the foregoing..

    4. You agree that in reoffering said  Securities,  if your offer is accepted
after the effective date, you will make a bona fide public distribution of same.
You will advise us upon request of Securities  purchased by you remaining unsold
and we shall have the right to  repurchase  such  Securities  upon demand at the
public  offering  price  without  paying  the  concession  with  respect  to any
Securities so  repurchased.  Any of the Securities  purchased by you pursuant to
this  Agreement are to be subject to the terms hereof.  Securities  shall not be
offered or sold by you below the public offering price before the termination of
this Agreement.

    5.  Payment for Securities which you purchase hereunder shall be made by you
on or before  five (5)  business  days  after the date of each  confirmation  by
certified or bank cashier's check payable to the  Underwriter.  Certificates for
the  Securities  shall  be  delivered  as soon  as  practicable  after  delivery
instructions are received by the Underwriter.

    6. A  registration  statement  covering the offering has been filed with the
Securities  and Exchange  Commission in respect to the  Securities.  You will be
promptly  advised  when  the  registration  statement  becomes  effective.  Each
Selected Dealer in selling  Securities  pursuant hereto agrees (which  agreement
shall  also be for the  benefit of the  Company)  that it will  comply  with the
applicable  requirements  of the  Securities  Act of 1933 and of the  Securities
Exchange Act of 1934 and any applicable rules and regulations  issued under said
Acts. No person is authorized by the Company or by the  Underwriter  to give any
information  or to make any  representations  other than those  contained in the
Prospectus  in connection  with the sale of the  Securities.  Nothing  contained
herein shall render the Selected Dealers a member of the  Underwriting  Group or
partners with the Underwriter or with one another.

    7. You will be informed by us as to the states in which we have been advised
by counsel the  Securities  have been qualified for sale or are exempt under the
respective  securities or blue sky laws of such states,  but we have not assumed
and will not  assume any  obligation  or  responsibility  as to the right of any
Selected  Dealer  to  sell  Securities  in any  state.  You  agree  not to  sell
Securities in any other state or jurisdiction  and to not sell Securities in any
state or jurisdiction unless you are qualified or licensed to sell securities in
such state or jurisdiction.

    8. The  Underwriter  shall have full authority to take such action as it may
deem  advisable in respect of all matters  pertaining to the offering or arising
thereunder. The Underwriter shall not be under any liability to you, except such
as may be  incurred  under  the  Securities  Act  of  1933  and  the  rules  and
regulations thereunder, except for lack of good faith and except for obligations
assumed by us in this Agreement,  and no obligation on our part shall be implied
or inferred herefrom.

    9.  Selected  Dealers  will be governed by the  conditions  herein set forth
until this  Agreement is  terminated.  This  Agreement  will  terminate when the
offering is completed.  Nothing herein contained shall be deemed a commitment on
our part to sell you any  Securities;  such  contractual  commitment can only be
made in accordance with the provisions of paragraph 3 hereof.

    10. You  represent  that you are a member in good  standing  of the NASD and
registered as a  broker-dealer  with the  Commission,  or that you are a foreign
broker-dealer  not eligible for membership  under Section 1 of the Bylaws of the
NASD who agrees to make no sales within the United  States,  its  territories or
possessions or to persons who are nationals thereof or residents therein and, in
making  sales,  to  comply  with  the  NASD's  interpretation  with  Respect  to
FreeRiding and  Withholding  and with Sections 2730, 2740 and 2420 to the extent
applicable  to foreign  nonmember  brokers and dealers,  and Section 2750 of the
NASD's  Rules of Fair  Practice.  Your  attention  is called to and you agree to
comply  with the  following:  (a)  Article  III,  Section 1 of the Rules of Fair
Practice of the NASD and


                                       2


the interpretations of said Section promulgated by the Board of Governors of the
NASD including  Section 24 and the  interpretation  with respect to "Free-Riding
and Withholding;"  (b) Section 10(b) of the 1934 Act and Rules 10b-6,  10b-10 of
the general rules and regulations  promulgated  under the 1934 Act; and (c) Rule
15c2-8 of the  general  rules  and  regulations  promulgated  under the 1934 Act
requiring the distribution of a preliminary Prospectus to all persons reasonably
expected to be purchasers of the Securities  from you at least 48 hours prior to
the time you  expect to mail  confirmations.  You,  as a member of the NASD,  by
signing this  Agreement,  acknowledge  that you are familiar with the cited laws
and rules and agree that you will not  directly  and/or  indirectly  violate any
provisions  of  applicable  law in  connection  with your  participation  in the
distribution of the Securities.

    11. In addition to  compliance  with the  provisions of paragraph 10 hereof,
you will not, until advised by us in writing or by wire that the entire offering
has been  distributed  and closed,  bid for or purchase  Securities  in the open
market or otherwise  make a market in the  Securities  or  otherwise  attempt to
induce others to purchase the Securities in the open market.  Nothing  contained
in this  paragraph 11 shall,  however,  preclude you from acting as agent in the
execution of unsolicited  orders of customers in  transactions  effectuated  for
them through a market maker.

    12. You understand  that the Underwriter may in connection with the offering
engage  in  stabilizing  transactions.  If  the  Underwriter  contracts  for  or
purchases  in  the  open  market  in  connection  with  such  stabilization  any
Securities  sold  to you  hereunder  and not  effectively  placed  by  you,  the
Underwriter may charge you the Selected Dealer's  concession  originally allowed
you on the  Securities  so  purchased  and you agree to pay such amount to us on
demand.

    13.  By  submitting  an Offer  to  Purchase  you  confirm  that you may,  in
accordance  with Rule 15c-1  adopted  under the 1934 Act,  agree to purchase the
number of Securities  you may become  obligated to purchase under the provisions
of this Agreement.

    14.  All  communications  from you  should be  directed  to us at  Schneider
Securities,Inc.,2 Charles Street, Providence, R.I. Attn: Pasquale Ruggieri, Vice
President (1 800-709-4040) and fax (401-274-8942). All communications from us to
you shall be directed to the address to which this letter is mailed.


Very truly yours,
Schneider Securities, Inc..



By
   ---------------------------------
        (Authorized Officer)


                                       3





                                OFFER TO PURCHASE

     The  undersigned  does hereby  offer to  purchase  (subject to the right to
revoke as set forth in paragraph 3)  _________________________  * Securities  in
accordance with the terms and conditions set forth above. We hereby  acknowledge
receipt of the Prospectus referred to in the first paragraph thereof relating to
such  Securities.  We further state that in purchasing  such  Securities we have
relied upon such Prospectus and upon no other statement  whatsoever,  written or
oral.


- ------------------------------------

By
    --------------------------------
                    (Authorized Officer)



*If a number appears here which does not correspond  with what you wish to offer
to purchase,  you may change the number by crossing out the number,  inserting a
different number and initializing the change.


                                                                     EXHIBIT 1.3


                              PERARDUA CORPORATION


                                1,000,000 SHARES
                                 OF COMMON STOCK
                                       AND
                          1,000,000 REDEEMABLE WARRANTS

                          AGREEMENT AMONG UNDERWRITERS

              , 19
Schneider Securities, Inc.
1120 Lincoln Street
Denver, Colorado 80203

GENTLEMEN:

     We wish to confirm as follows the agreement  among you, the undersigned and
the  other  members  of  the  Underwriting  Group  named  in  Schedule  I to the
Underwriting  Agreement,  as it is to be executed (all such parties being herein
called the  "Underwriters"),  with respect to the  purchase by the  Underwriters
severally  from PerArdua  Corporation  ("Company") of shares of Common Stock and
Redeemable  Warrant  ("Securities")  set forth in Schedule I to the Underwriting
Agreement. The number of Securities to be purchased by each Underwriter from the
Company shall be determined  in  accordance  with Section 2 of the  Underwriting
Agreement.  It is  understood  that  changes  may be made in those who are to be
Underwriters  and in the  respective  numbers of  Securities  to be purchased by
them,  but that the  Underwriting  Agreement  will not be  changed  without  our
consent,  except as provided  herein,  and in the  Underwriting  Agreement.  The
obligations  of the  Underwriters  to  purchase  the  number of  Securities  set
opposite their respective names in Schedule I to the Underwriting Agreement, are
herein called their  "underwriting  obligations."  The number of Securities  set
opposite our name in said  Schedule I, are herein called "our  Securities."  For
purposes of this Agreement the following definitions shall be applicable:

      (a) "Manager's  Concession" shall be the compensation to you for acting as
Manager  as  provided  in  Paragraph  1 of not  less  than  percent  ( %) of the
underwriting  discount.  The Manager's  Concession  shall include the right to a
portion of the warrants to be issued pursuant to the Underwriting Agreement and,
the right to the nonaccountable expenses to be paid pursuant to the Underwriting
Agreement.

      (b) "Underwriting  Group Concession" shall mean compensation to members of
the Underwriting  Group for assuming the underwriting risk and shall be not less
than percent ( %) of the underwriting discount.

      (c) "Dealer's  Concession"  shall mean  compensation  to Dealers,  who are
members of the  Selling  Group and shall,  as to Dealers  who have  executed  an
agreement with you, be not less than percent ( %) of the underwriting discount.

      (d) "Dealer's Reallowance  Concession" shall mean the compensation allowed
Dealers  by  Underwriters  other  than you and  shall be  one-half  (1/2) of the
Dealer's Concession.

     (e) It is contemplated  that the underwriting  discount will be ten percent
(10%) of the offering price. You, in your absolute discretion,  shall determine,
within the foregoing  limitations,  the






precise  allocation of the underwriting  discount and shall notify us of same at
least  twenty-four  (24)  hours  prior  to the  execution  of  the  Underwriting
Agreement.



1. Authority and Compensation of Representative. We hereby authorize you, as our
Representative  and on our  behalf,  (a) to  enter  into an  agreement  with the
Company  substantially  in the form attached hereto as Exhibit A  ("Underwriting
Agreement"),  but  with  such  changes  therein  as in  your  judgment  are  not
materially  adverse to the  Underwriters,  (b) to exercise all the authority and
discretion  vested  in the  Underwriters  and in  you by the  provisions  of the
Underwriting  Agreement,  and (c) to  take  all  such  action  as  you,  in your
discretion, may deem necessary or advisable in order to carry out the provisions
of the  Underwriting  Agreement and this Agreement and the sale and distribution
of  the  Securities,   provided,   however,  that  the  time  within  which  the
Registration   Statement  is  required  to  become  effective  pursuant  to  the
Underwriting  Agreement  will not be extended more than  forty-eight  (48) hours
without the  approval of a majority in interest of the  Underwriters  (including
you). We authorize you, in executing the  Underwriting  Agreement on our behalf,
to set forth in Schedule I of the  Underwriting  Agreement as our  commitment to
purchase the number of Securities (which shall not be substantially in excess of
the number of Securities  included in your  invitation to participate  unless we
have  agreed  otherwise)  included  in  a  wire,  telex,  or  similar  means  of
communication  transmitted by you to us at least twenty-four (24) hours prior to
the commencement of the offering as our finalized underwriting participation.

As our share of the compensation for your services  hereunder,  we will pay you,
and we  authorize  you to charge to our  account,  a sum equal to the  Manager's
Concession.

    2.  Public  Offering.  A public offering of the Securities is to be made, as
herein provided, as soon after the Registration Statement relating thereto shall
become  effective as in your  judgment is  advisable.  The  Securities  shall be
initially  offered to the public at the  public  offering  price of $ ______ per
share and $ _____ per  Redeemable  Warrant.  You will advise us by  telegraph or
telephone when the Securities  shall be released for offering.  We authorize you
as  Representative of the  Underwriters,  after the initial public offering,  to
vary the public offering price, in your sole discretion, by reason of changes in
general  market  conditions  or  otherwise.  The  public  offering  price of the
Securities at any time in effect is herein called the "Offering Price."

    We  hereby  agree to  deliver  all  preliminary  and final  Prospectuses  as
required for compliance  with the provisions of Rule 15c2-8 under the Securities
Exchange Act of 1934 and Section 5(b) of the  Securities  Act of 1933.  You have
heretofore delivered to us such preliminary  Prospectuses as have been requested
by us,  receipt of which is hereby  acknowledged,  and will  deliver  such final
Prospectuses as will be requested by us.

    3.  Offering to Dealers and Group  Sales.  We  authorize  you to reserve for
offering and sale,  and on our behalf to sell, to  institutions  or other retail
purchasers  (such  sales  being  herein  called  "Group  Sales")  and to dealers
selected by you (such dealers being herein called the "Dealers") all or any part
of our Securities as you may determine.  Such sales of Securities, if any, shall
be made (i) in the case of Group Sales, at the Offering  Price,  and (ii) in the
case of sales to Dealers, at -the Offering Price less the Dealer's Concession.

    Any Group  Sales  shall be as nearly as  practicable  in  proportion  to the
underwriting  obligations of the respective  Underwriters.  Any sales to Dealers
made for our  account  shall be as nearly as  practicable  in the ratio that the
Securities  reserved  for our  account  for  offering  to  Dealers  bears to the
aggregate of all Securities of all Underwriters,  including you, so reserved. On
any  Group  Sales or sales to  Dealers  made by you on our  behalf,  we shall be
entitled to receive only the Underwriter's Concession.



2


You  agree to  notify  us not less  than  twenty-four  (24)  hours  prior to the
commencement  of the public  offering  as to the number of  Securities,  if any,
which we may retain for direct sale. Prior to the termination of this Agreement,
you may reserve for offering and sale, as herein before provided, any Securities
remaining  unsold  theretofore  retained  by us and we may,  with your  consent,
retain any Securities  remaining  unsold  theretofore  reserved by you. Sales to
Dealers shall be made under a Selected  Dealers  Agreement,  attached  hereto as
Exhibit  B and by  this  reference  incorporated  herein.  We  authorize  you to
determine the form and manner of any  communications  with Dealers,  and to make
such changes in the Selected Dealers Agreement, as you may deem appropriate.  In
the  event  that  there  shall  be any such  agreements  with  Dealers,  you are
authorized to act as managers  thereunder,  and we agree,  in such event,  to be
governed by the terms and conditions of such agreements. Each Underwriter agrees
that it will not  offer  any of the  Securities  for sale at a price  below  the
Offering Price or allow any  concession  therefrom,  except as herein  otherwise
provided. We, as to our Securities,  may enter into agreements with Dealers, but
any  Dealer's  Reallowance  Concession  shall not  exceed  half of the  Dealer's
Concession.

It is understood  that any person to whom an offer may be made, as herein before
provided,  shall be a member of the National  Association of Securities Dealers,
Inc.  ("NASD") or dealers or institutions with their principal place of business
located outside of the United States,  its  territories or possessions,  and who
are not eligible for  membership  under  Section 1 of the Bylaws of the NASD who
agree to make no sales within the United States, its territories or possessions,
or to persons who are nationals thereof,  or residents  therein,  and, in making
sales, to comply with the NASD's Rules of Fair Practice.

We authorize you to determine the form and manner of any public advertisement of
the Securities.

Nothing  in this  Agreement  contained  shall be deemed to  restrict  our right,
subject to the  provisions of this Section 3, to offer our  Securities  prior to
the effective date of the Registration  Statement,  provided,  however, that any
such offer shall be made in compliance  with any applicable  requirements of the
Securities Act of 1933 and the Securities Exchange Act of 1934 and the rules and
regulations  of the  Securities  and Exchange  Commission  thereunder and of any
applicable state securities laws.

    4. Repurchases in the Open Market. Any Securities sold by us (otherwise than
through you) which, prior to the termination of this Agreement,  or such earlier
date as you may  determine,  shall be  contracted  for or  purchased in the open
market by you on behalf of any Underwriter or Underwriters, shall be repurchased
by us on demand at a price equal to the cost of such purchase  plus  commissions
and taxes,  if any, on redelivery.  Any Securities  delivered on such repurchase
need not be the identical Securities  originally sold by us. In lieu of delivery
of such Securities to us, you may (i) sell such Securities in any manner for our
account and charge us with the amount of any loss or expense,  or credit us with
the amount of any profit,  less any expense,  resulting  from such sale, or (ii)
charge our account . t with an amount not in excess of the concession to Dealers
on such Securities.

    5. Delivery and Payment. We agree to deliver to you, at or before 9:00 A.M.,
New York,  New York Time,  on the Closing Date  referred to in the  Underwriting
Agreement,  at your office,  a certified or bank cashier's check payable to your
order for the offering price of the Securities  less Dealer's  Concession of the
Securities  which we retained for direct sale by us, the proceeds of which check
shall be delivered to you, in the manner provided in the Underwriting Agreement,
to or for the account of the Company against  delivery of certificates  for such
Securities  to you for our account.  You are  authorized to accept such delivery
and to give receipts  therefor.  You may advance funds for Securities which have
been sold or reserved for sale to retail  purchasers or Dealers for our account.
If we fail (whether or not such failure shall constitute a default hereunder) to
deliver to you, or you fail to receive,  our check and/or payment for sales made
by


3


you for our account for the  Securities  which we have agreed to purchase,  you,
individually and not as Representative of the Underwriters,  are authorized (but
shall  not be  obligated)  to  make  payment,  in  the  manner  provided  in the
Underwriting Agreement, to or for the account of the Company for such Securities
for our account,  but any such payment by you shall not relieve us of any of our
obligations  under the  Underwriting  Agreement or under this  Agreement  and we
agree to repay you on demand the amount so advanced for our account.

         We also  agree on  demand to take up and pay for or to  deliver  to you
funds  sufficient to pay for at cost any Securities of the Company  purchased by
you for our  account  pursuant  to the  provisions  of Section 9 hereof,  and to
deliver to you on demand any Securities sold by you for our account, pursuant to
any provision of this Agreement.

         We authorize you to deliver our  Securities,  and any other  Securities
purchased by you for our account pursuant to the provisions of Section 9 hereof,
against  sales made by you for our  account  pursuant to any  provision  of this
Agreement.

Upon receipt by you of payment for the Securities  sold by us and/or through you
for  our  account,  you  will  remit  to us  promptly  an  amount  equal  to the
Underwriter's Concession on such Securities.  You agree to cause to be delivered
to us,  as soon  as  practicable  after  the  Closing  Date  referred  to in the
Underwriting  Agreement,  such part of our Securities  purchased on such Closing
Date as shall not have been sold or reserved for sale by your for our account.

In case any Securities  reserved for sale in Group Sales or to Dealers shall not
be  purchased  and paid for in due course as  contemplated  hereby,  we agree to
accept  delivery  when  tendered by you of any  Securities  so reserved  for our
account and not so purchased  and pay you the  offering  price less the Dealer's
and Underwriter's Concessions.

    6.  Authority  to Borrow.  We  authorize  you to advance  your funds for our
account  (charging  current interest rates) and to arrange loans for our account
for the purpose of carrying out this Agreement,  and in connection  therewith to
execute and deliver any notes or other  instruments,  and to hold,  or pledge as
security  therefor,  all or any part of our Securities of the Company  purchased
hereunder for our account.  Any lending bank is hereby authorized to accept your
instructions as  Representative  in all matters relating to such loans. Any part
of our Securities held by you, may be delivered to us for carrying purposes, and
if so delivered, will be redelivered to you upon demand.

    7.  Allocation  of Expense and  Liability.  We  authorize  you to charge our
account  with,  and we agree to pay (a) all transfer  taxes on sales made by you
for our account,  except as herein otherwise provided, and (b) our proportionate
share (based on our underwriting obligations) of all expenses in excess of those
reimbursed  by the Company  incurred  by you in  connection  with the  purchase,
carrying  and  distribution,  or  proposed  purchase  and  distribution,  of the
Securities  and all other expenses  arising under the terms of the  Underwriting
Agreement or this Agreement.  Your  determination  of all such expenses and your
allocation  thereof shall be final and conclusive.  Funds for our account at any
time in your  hands  as our  Representative  may be held in your  general  funds
without   accountability  for  interest.   As  soon  as  practicable  after  the
termination of this  Agreement,  the net credit or debit balance in our account,
after proper charge and credit for all interim  payments and receipts,  shall be
paid to or paid by us,  provided,  however,  that you, in your  discretion,  may
reserve  from  distribution  an amount  to cover  possible  additional  expenses
chargeable to the several Underwriters.

    8.  Liability  for  Future   Claims.   Neither  any  statement  by  you,  as
Representative  of the  Underwriters,  of any  credit  or debit  balance  in our
account nor any  reservation  from  distribution  to cover  possible  additional
expenses  relating to the Securities shall constitute any  representation by you
as  to  the  existence  or  nonexistence  of  possible  unforeseen  expenses  or
liabilities of or charges against the several Underwriters.  Notwithstanding the
distribution  of any  net  credit



4


balance to us or the  termination  of this  Agreement,  or both, we shall be and
remain liable for, and will pay on demand, (a) our proportionate share (based on
our  underwriting  obligations)  of all  expenses and  liabilities  which may be
incurred by, or for the accounts of the  Underwriters,  including  any liability
which may be incurred by the  Underwriters  or any of them, and (b) any transfer
taxes paid  after such  settlement  on account of any sale or  transfer  for our
account.

    9. Stabilization. We authorize you, until the termination of this Agreement,
(a) to make  purchases  and  sales  of the  Securities,  in the open  market  or
otherwise,  for long or short account,  and on such terms, and at such prices as
you in your  discretion  may  deem  desirable,  (b) in  arranging  for  sales of
Securities, to overallot, and (c) either before or after the termination of this
Agreement,  to cover any short  position  incurred  pursuant to this  Section 9;
subject,  however, to the applicable rules and regulations of the Securities and
Exchange  Commission  under  the  Securities  Exchange  Act of  1934.  All  such
purchases,  sales  and  overallotments  shall  be made for the  accounts  of the
several  Underwriters as nearly as practicable in proportion to their respective
underwriting  obligations;  provided,  however,  that our net position resulting
from such purchases and sales and  overallotments  shall not at any time exceed,
either  for long or short  account,  fifteen  percent  (15%)  of the  number  of
Securities agreed to be purchased by us.

If  you  engage  in  any  stabilizing  transactions  as  representative  of  the
underwriters,  you shall promptly  notify us of that fact and in like manner you
agree  to  promptly  notify  and file  with us any  stabilizing  transaction  in
accordance with the requirements of Rule 17a-2(d) under the Securities  Exchange
Act of 1934.

We agree to advise you from time to time, upon request,  until the settlement of
accounts  hereunder,  of the number of  Securities  at the time  retained  by us
unsold, and we will upon request sell to you, for the accounts of one or more of
the  several  Underwriters,  such  number of our  unsold  Securities  as you may
designate,  at the  Offering  Price  less  such  amount,  not in  excess  of the
concession to Dealers, as you may determine.



    10. Open Market  Transactions.  We agree that,  except with your consent and
except as herein  provided  upon advice from you, we will not make  purchases or
sales on the open  market or  otherwise,  or  attempt  to induce  others to make
purchases or sales,  either before or after the purchase of the Securities,  and
prior to the completion (as defined in Rule 10b-6 of the Securities Exchange Act
of 1934) of our participation in the distribution, we will otherwise comply with
Rule 10b-6.  Nothing in this Section 10 contained  shall prohibit us from acting
as broker or agent in the execution of  unsolicited  orders of customers for the
purchase or sale of any securities of the Company.

    11. Blue Sky. Prior to the initial  offering by the  Underwriters,  you will
inform us as to the states under the  respective  securities or Blue Sky laws of
which it is believed that the  Securities  have been qualified or are exempt for
sale, but you do not assume any  responsibility or obligation as to the accuracy
of such  information or as to the right of any Underwriter or Dealer to sell the
Securities  in any  jurisdiction.  We will not sell any  Securities in any other
state  or  jurisdiction  and  we  will  not  sell  Securities  in any  state  or
jurisdiction  unless we are  qualified  or licensed to sell  securities  in such
state or jurisdiction. We authorize you, if you deem it unadvisable in arranging
sales of Securities for our account hereunder,  to sell any of our Securities to
any  particular  Dealer,  or other buyer,  because of the securities or Blue Sky
laws  of  any  jurisdiction,  to  sell  our  Securities  to one  or  more  other
Underwriters  at the Offering  Price less,  in the case of a sale to any Dealer,
such amount,  not in excess of the  concession  to Dealers  thereon,  as you may
determine.  The  transfer  tax on any such  sales  among  Underwriters  shall be
treated as an expense  and  charged to the  respective  accounts  of the several
Underwriters, in proportion to their respective underwriting obligations.



5


    12. Default by Underwriters. Default by one or more Underwriters, in respect
to their obligations under the Underwriting  Agreement shall not release us from
any of our obligations. In case of such default by one or more Underwriters, you
are authorized to increase, pro rata, with the other nondefaulting Underwriters,
the number of defaulted  Securities which we shall be obligated to purchase from
the Company, provided,  however, that the aggregate amount of all such increases
for all Underwriters shall not exceed ten percent (10%) of such Securities, and,
if the  aggregate  number  of the  Securities  not  taken up by such  defaulting
Underwriters  exceeds such ten percent (10%),  you are further  authorized,  but
shall not be obligated,  to arrange for the purchase by other  persons,  who may
include  yourselves,  of all or a portion of the Securities not taken up by such
Underwriters.  In the event any such  increases or  arrangements  are made,  the
respective   numbers  of  Securities  to  be  purchased  by  the   nondefaulting
Underwriters and by any such other person or persons shall be taken as the basis
for the underwriting obligations under this Agreement, but this shall not in any
way  affect  the  liability  of  any  defaulting   Underwriters   to  the  other
Underwriters for damages resulting from such default.

In the  event  of  default  by one or more  Underwriters  in  respect  of  their
obligations under this Agreement to take up and pay for any Securities purchased
by your for their  respective  accounts,  pursuant  to  Section 9 hereof,  or to
deliver any such Securities  sold or  overallotted  by you for their  respective
accounts  pursuant to any provisions of this  Agreement,  and to the extent that
arrangements  shall not have been made by you for other  persons  to assume  the
obligations of such defaulting  Underwriter or Underwriters,  each nondefaulting
Underwriter shall assume its proportionate share of the aforesaid obligations of
each such defaulting  Underwriter  without relieving any such Underwriter of its
liability therefor.

    13.  Termination  of  Agreement.  Unless  earlier  terminated  by  you,  the
provisions of Sections 2, 3, 4, 6, 9 and 10 of this Agreement  shall,  except as
otherwise  provided therein,  terminate thirty (30) full business days after the
effective  date of the  Registration  Statement  herein  referred to, but may be
extended by you for an additional  period or periods not  exceeding  thirty (30)
full business days in the aggregate. You may, however, terminate this Agreement,
or any provisions hereof, at any time by written or telegraphic notice to us.

    14.  General  Position of the  Representative.  In taking  action under this
Agreement,  you  shall  act  only as  agent of the  several  Underwriters.  Your
authority as Representative of the several Underwriters shall include the taking
of such action as you may deem advisable in respect of all matters pertaining to
any and all offers and sales of the Securities,  including the right to make any
modifications which you consider necessary or desirable in the arrangements with
Dealers  or  others.  You shall be under no  liability  for or in respect of the
value of the  Securities or the validity or the form thereof,  the  Registration
Statement,  the Prospectus,  the Underwriting  Agreement,  or other  instruments
executed by the  Company or others of any  agreement  on its or their part;  nor
shall you,  as such  Representative  or  otherwise,  be liable  under any of the
provisions  hereof,  or for any matters connected  herewith,  except for want of
good faith,  and except for any liability  arising under the  Securities  Act of
1933;  and no  obligation  not expressly  assumed by you as such  Representative
herein shall be implied from this Agreement.  In representing  the  Underwriters
hereunder,  you shall act as the  representative  of each of them  respectively.
Nothing herein contained shall constitute the several Underwriters partners with
you or with each other, or render any Underwriter  liable for the commitments of
any other  Underwriter,  except as otherwise  provided in Section 12 hereof. The
commitments and liabilities of each of the several  Underwriters  are several in
accordance with their respective underwriting obligations and are not joint.

    15. Acknowledgment of Registration Statement, etc. We hereby confirm that we
have examined the  Registration  Statement  (including all  amendments  thereto)
relating to the Securities as heretofore  filed with the Securities and Exchange
Commission,  that we are  familiar  with the



6


amendment(s)  to the  Registration  Statement  and the final form of  Prospectus
proposed to be filed, that we are willing to accept the  responsibilities  of an
underwriter  thereunder,   and  that  we  are  willing  to  proceed  as  therein
contemplated.  We further  confirm  that the  statements  made under the heading
"Underwriting"  in such  proposed  final form of  Prospectus  are correct and we
authorize  you so to advise the Company on our behalf.  We  understand  that the
aforementioned  documents  are  subject  to  further  change and that we will be
supplied  with  copies  of any  amendment  or  amendments  to  the  Registration
Statement and of any amended Prospectus  promptly,  if and when received by you,
but the making of such changes and amendments shall not release us or affect our
obligations hereunder or under the Underwriting Agreement.

    16.  Indemnification.  Each Underwriter,  including you, agrees to indemnify
and hold harmless each other  Underwriter and each person who controls any other
Underwriter  within the meaning of Section 15 of the  Securities Act of 1933, as
amended,  to the  extent of their  several  commitments  under the  Underwriting
Agreement and upon the terms that such Underwriter  agrees to indemnify and hold
harmless  the Company as set forth in Section 7 of the  Underwriting  Agreement.
The Agreement contained in this Section 16 shall survive any termination of this
Agreement Among Underwriters.

    17.   Capital   Requirements.   We  confirm  that  our  ratio  of  aggregate
indebtedness to net capital is such that we may, in accordance with and pursuant
to Rule 15c-1,  promulgated by the Securities and Exchange  Commission under the
Securities  Exchange Act of 1934,  agree to purchase the number of Securities we
may be obligated to purchase under any provision of the  Underwriting  Agreement
or this Agreement.

    18.  Miscellaneous.  We have transmitted herewith a completed  Underwriters'
Questionnaire on the form thereof supplied by you. Any notice hereunder from you
to us or from us to you  shall  be  deemed  to have  been  duly  give if sent by
registered mail, telegram,  teletype, telex, telecopier,  graphic scan, or other
written  form of  telecommunication  to us at our  address  as set  forth in the
Underwriting  Agreement, or to you at the address set forth on the first page of
this Agreement.

         You hereby confirm that you are registered as a broker-dealer  with the
United States  Securities  and Exchange  Commission and that you are a member of
the NASD and we  confirm  that we are  either a member  of the NASD or a foreign
broker-dealer  not eligible for membership  under Section I of the Bylaws of the
NASD, who agrees to make no sales within the United States,  its  territories or
possessions,  or to persons who are nationals thereof or residents therein, and,
in making sales, to comply with the  requirements  of the NASD's  Interpretation
with Respect to Free Riding and Withholding,  and with Sections 8, 24, and 25 to
the extent applicable to foreign nonmember brokers or dealers, and Section 36 of
the NASD's Rules of Fair Practice.

We will comply with all applicable federal laws, the laws of the states or other
jurisdictions  concerned and the Rules and  Regulations of the NASD,  including,
but not limited to, Section 24 of the Rules of Fair Practice.






This instrument may be signed by the Underwriters in various  counterparts which
together shall  constitute one and the same agreement among all the Underwriters
and  shall  become  effective  as  between  us at such  time as you  shall  have
confirmed same by returning an executed copy to us, and thereafter, as to us and
the  other  Underwriters,  upon  execution  by them of  counterparts  which  are
confirmed by you. In no event,  however,  shall we have any liability under this
Agreement if the Underwriting Agreement is not executed.


7



Please confirm that the foregoing correctly states the understanding  between us
by signing and returning to us a counterpart hereof.



Very truly yours,



Attorney-in-Fact
for the several Underwriters
named in Schedule I
to the Underwriting Agreement



Confirmed as of the date first above written.

Schneider Securities,Inc.
As Representative



By
         President



8

                                                                     EXHIBIT 3.1

                          CERTIFICATE OF INCORPORATION

                                       OF

                              PERARDUA CORPORATION

                                    ARTICLE I

                                      NAME
                                      ----

         The name of the Corporation is PerArdua Corporation.

                                   ARTICLE II

                                REGISTERED OFFICE
                                -----------------

         The address of the registered office of the Corporation in the State of
Delaware is 1209 Orange Street, in the City of Wilmington, County of New Castle.
The  name of its  registered  agent at such  address  is The  Corporation  Trust
Company.

                                   ARTICLE III

                                    PURPOSES
                                    --------

         The nature of the  business or purposes to be  conducted or promoted by
the  Corporation  is  to  engage  in  any  lawful  act  or  activity  for  which
corporations may be organized under the General  Corporation Law of the State of
Delaware (the "DGCL").

                                   ARTICLE IV

                                  CAPITAL STOCK
                                  -------------

         Section 1.  Number of Shares.

         The total number of shares of capital stock which the Corporation shall
have the authority to issue is 26,000,000  shares, of which (i) 1,000,000 shares
shall be Preferred Stock,  par value $.01 per share (the "Preferred  Stock") and
(ii)  25,000,000  shares  shall be common  stock,  par value $.01 per share (the
"Common Stock"). As set forth in this Article IV and subject to the terms of any
series of Preferred  Stock  (provided  that any shares of such series are issued
and outstanding),  the Board of Directors or any authorized committee thereof is
authorized  from time to time to establish  and  designate one or more series of
Preferred  Stock, to fix and determine the variations in the relative rights and
preferences  as between the  different  series of Preferred  Stock in the manner
hereinafter  set forth in this  Article  IV,  and to 







fix or alter the number of shares comprising any such series and the designation
thereof to the extent permitted by law.

         Except as provided to the  contrary in the  provisions  establishing  a
class of stock or a series of Preferred Stock,  the number of authorized  shares
of such class or series may be increased or decreased  (but not below the number
of shares thereof then outstanding) by the affirmative vote of a majority of the
stock of the Corporation entitled to vote, voting as a single class.

         Section 2.  General.
         
         The   designations,   powers,   preferences  and  rights  of,  and  the
qualifications, limitations and restrictions upon, each class or series of stock
shall be determined in accordance with, or as set forth below in, Sections 3 and
4 of this Article IV.

         Section 3.  Common Stock.

         Subject to all of the rights,  powers and  preferences of the Preferred
Stock,  and  except  as  provided  by  law  or in  this  Article  IV  (or in any
certificate of designation of any series of Preferred  Stock,  provided that any
shares of such series are issued and  outstanding)  or by the Board of Directors
or any authorized committee thereof pursuant to this Article IV:

                  (a)  the holders of the Common Stock shall have the  exclusive
right to vote for the election of Directors and on all other  matters  requiring
stockholder action, each share being entitled to one vote;

                  (b)  dividends  may be  declared  and  paid or set  apart  for
payment  upon the  Common  Stock out of any  assets or funds of the  Corporation
legally available for the payment of dividends, but only when and as directed by
the Board of Directors or any authorized committee thereof; and

                  (c) upon the voluntary or involuntary liquidation, dissolution
or winding up of the  Corporation,  the net assets of the  Corporation  shall be
distributed pro rata to the holders of the Common Stock in accordance with their
respective rights and interests.

         Section 4.  Preferred Stock.

         Subject  to any  limitations  prescribed  by law or by the terms of any
series of Preferred  Stock  (provided  that any shares of such series are issued
and outstanding),  the Board of Directors or any authorized committee thereof is
expressly  authorized  to provide for the  issuance  of the shares of  Preferred
Stock in one or more series of such stock, and by filing a certificate  pursuant
to applicable law of the State of Delaware,  to establish or change from time to
time the number of shares to be  included  in each such  series,  and to fix the
designations,  powers, preferences and the relative, participating,  optional or
other  special


                                       2



rights of the shares of each  series  and any  qualifications,  limitations  and
restrictions  thereof.  Any action by the Board of Directors  or any  authorized
committee  thereof under this Section 4 shall require the affirmative  vote of a
majority  of the  Directors  then in office or a majority of the members of such
committee. The Board of Directors or any authorized committee thereof shall have
the right to determine to fix one or more of the following  with respect to each
series of Preferred Stock to the extent permitted by law:

                  (a) The  distinctive  serial  designation  and the  number  of
shares constituting such series;

                  (b) The  dividend  rates or the amount of dividends to be paid
on the shares of such series,  whether dividends shall be cumulative and, if so,
from which  date or dates,  the  payment  date or dates for  dividends,  and the
participating and other rights, if any, with respect to dividends;

                  (c) The voting powers,  full or limited, if any, of the shares
of such series;

                  (d) Whether the shares of such series shall be redeemable and,
if so, the price or prices at which, and the terms and conditions on which, such
shares may be redeemed;

                  (e) The  amount or  amounts  payable  upon the  shares of such
series  and any  preferences  applicable  thereto in the event of  voluntary  or
involuntary liquidation, dissolution or winding up of the Corporation;

                  (f) Whether the shares of such series shall be entitled to the
benefit  of a sinking  or  retirement  fund to be  applied  to the  purchase  or
redemption of such shares,  and if so entitled,  the amount of such fund and the
manner of its  application,  including  the price or prices at which such shares
may be redeemed or purchased through the application of such fund;

                  (g) Whether  the shares of such  series  shall be  convertible
into, or exchangeable  for, shares of any other class or classes or of any other
series of the same or any other  class or  classes  of stock of the  Corporation
and, if so convertible or exchangeable,  the conversion price or prices,  or the
rate or rates of exchange,  and the adjustments  thereof,  if any, at which such
conversion  or  exchange  may be made,  and any  terms  and  conditions  of such
conversion or exchange;

                  (h) The price or other  consideration  for which the shares of
such series shall be issued;

                  (i) Whether the shares of such  series  which are  redeemed or
converted  shall have the status of authorized but unissued  shares of Preferred
Stock (or series  thereof)  and



                                       3




whether  such shares may be reissued as shares of the same or any other class or
series of stock; and

                  (j) Such other powers,  preferences,  rights,  qualifications,
limitations and restrictions thereof as the Board of Directors or any authorized
committee thereof may deem advisable.

                                    ARTICLE V

                               STOCKHOLDER ACTION
                               ------------------

         Any action required or permitted to be taken by the stockholders of the
Corporation at any annual or special  meeting of stockholders of the Corporation
must be effected at a duly called annual or special meeting of stockholders  and
may not be taken or  effected  by a  written  consent  of  stockholders  in lieu
thereof.

                                   ARTICLE VI

                                    DIRECTORS
                                    ---------

         Section 1.  General.

         The  business  and  affairs of the  Corporation  shall be managed by or
under the  direction of the Board of  Directors,  except as  otherwise  provided
herein or required by law.

         Section 2.  Election of Directors.

         Election of Directors  need not be by written  ballot unless the Bylaws
of the Corporation shall so provide.

         Section 3.  Number and Terms of Directors.

         The number of Directors of the Corporation shall be fixed by resolution
duly adopted from time to time by the Board of Directors.  The Directors,  other
than  those who may be elected  by the  holders  of any  series of  Undesignated
Preferred  Stock of the  Corporation,  shall be classified,  with respect to the
term for which they severally hold office, into three classes as nearly equal in
number as possible.  The initial Class I Directors of the  Corporation  shall be
Emanuela I. Charlton,  Ph.D. and Thomas Quinn; the initial Class II Directors of
the Corporation  shall be Samuel P. Sears, Jr. and William Lewin,  M.D.; and the
initial  Class III Director of the  Corporation  shall be Francis E.  O'Donnell,
Jr., M.D. The initial  Class I Directors  shall serve for a term expiring at the
annual  meeting  of  stockholders  to be held in  1997,  the  initial  Class  II
Directors  shall serve for a term expiring at the annual meeting of stockholders
to be held in 1998;  and the initial  Class III Director  shall serve for a term
expiring  at the annual  meeting  of  stockholders  to be held in 1999.  At each
annual  meeting of  stockholders,  the  successor or  successors of the class of
Directors  whose term expires at that meeting shall be elected by a plurality of
the votes cast at such meeting and shall hold office for a term




                                       4




expiring at the annual meeting of stockholders  held in the third year following
the year of their  election.  The  Directors  elected to each  class  shall hold
office  until their  successors  are duly  elected and  qualified or until their
earlier resignation or removal.

         Notwithstanding the foregoing,  whenever, pursuant to the provisions of
Article IV of this Certificate of Incorporation,  the holders of any one or more
series of Undesignated  Preferred Stock shall have the right,  voting separately
as a series or together with holders of other such series, to elect Directors at
an annual or special  meeting of  stockholders,  the  election,  term of office,
filling of vacancies and other features of such directorships  shall be governed
by the  terms  of this  Certificate  of  Incorporation  and any  certificate  of
designations  applicable  thereto,  and such  Directors so elected  shall not be
divided into classes pursuant to this Section 3.

         During any period  when the  holders of any series of  Preferred  Stock
have the right to elect  additional  Directors as provided for or fixed pursuant
to the  provisions  of  Article IV hereof,  then upon  commencement  and for the
duration of the period during which said right continues: (i) the then otherwise
total authorized number of Directors of the Corporation  shall  automatically be
increased  by such  specified  number  of  Directors,  and the  holders  of such
Preferred Stock shall be entitled to elect the additional  Directors so provided
for or fixed pursuant to said provisions, and (ii) each such additional Director
shall serve until such  Director's  successor  shall have been duly  elected and
qualified,  or until  such  Director's  right  to hold  such  office  terminates
pursuant  to  said  provisions,   whichever  occurs  earlier,  subject  to  such
Director's earlier death,  disqualification,  resignation or removal.  Except as
otherwise  provided by the Board in the resolution or  resolutions  establishing
such series,  whenever the holders of any series of Preferred  Stock having such
right to elect  additional  Directors are divested of such right pursuant to the
provisions of such stock,  the terms of office of all such additional  Directors
elected by the holders of such stock, or elected to fill any vacancies resulting
from the death,  resignation,  disqualification  or  removal of such  additional
Directors,  shall  forthwith  terminate and the total and  authorized  number of
Directors of the Corporation shall be reduced accordingly.

         Section 4.  Removal.

         Subject to the  rights,  if any,  of any series of  Preferred  Stock to
elect  Directors  and to remove any Director  whom the holders of any such stock
have the right to elect, any Director (including persons elected by Directors to
fill  vacancies in the Board of  Directors)  may be removed from office (i) only
with cause and (ii) only by the affirmative  vote of at least  two-thirds of the
total votes which would be eligible to be cast by  stockholders  in the election
of such Director. At least 30 days prior to any meeting of stockholders at which
it is proposed that any Director be removed from office,  written notice of such
proposed  removal shall be sent to the Director whose removal will be considered
at the meeting. For purposes of this



                                       5




Certificate  of  Incorporation,  "cause,"  with  respect  to the  removal of any
Director shall mean only (i) conviction of a felony, (ii) declaration of unsound
mind by order of court,  (iii) gross dereliction of duty, (iv) commission of any
action  involving  moral  turpitude,  or  (v)  commission  of  an  action  which
constitutes  intentional misconduct or a knowing violation of law if such action
in either event  results both in an improper  substantial  personal  benefit and
material injury to the Corporation.


                                   ARTICLE VII

                                 INDEMNIFICATION
                                 ---------------

         Section 1.  Definitions.  For purposes of this Article:

         (a)  "Officer"   means  any   person  who  serves  or  has  served  the
Corporation (i) as a director on the Board of Directors of the  Corporation,  or
(ii) as an officer appointed by the Board of Directors of the Corporation;

         (b)  "Non-Officer  Employee"  means any person who serves or has served
as an employee of the Corporation, but who is not or was not an Officer;

         (c)  "Proceeding" means any threatened,  pending,  or completed action,
suit,   arbitration,    alternate   dispute   resolution   mechanism,   inquiry,
investigation,  administrative  hearing  or  other  proceeding,  whether  civil,
criminal, administrative, arbitrative or investigative;

         (d)  "Expenses" means all reasonable attorney's fees, retainers,  court
costs,  transcript costs, fees of expert  witnesses,  private  investigators and
professional advisors (including, without limitation, accountants and investment
bankers), travel expenses,  duplicating costs, printing and binding costs, costs
of preparation of demonstrative  evidence and other courtroom  presentation aids
and devices,  costs incurred in connection with document  review,  organization,
imaging and computerization,  telephone charges, postage, delivery service fees,
and other  disbursements,  costs or expenses of the type customarily incurred in
connection  with  prosecuting,  defending,  preparing  to  prosecute  or defend,
investigating,  being or  preparing  to be a witness in,  settling or  otherwise
participating in, a Proceeding;

         (e) "Corporate  Status" describes the status of a person who (i) in the
case of an  Officer,  is or was a  director,  officer,  employee or agent of the
Corporation or of any other  corporation,  partnership,  joint  venture,  trust,
employee  benefit plan or other  enterprise which such Officer is or was serving
at the written request of the Corporation,  or (ii) in the case of a Non-Officer
Employee,  is or was an employee  of the  Corporation  or a  director,  officer,
employee or agent of any other corporation,  partnership,  joint venture, trust,
employee benefit plan or other enterprise which such Non-Officer  Employee is or
was serving at the written request of the Corporation; and



                                       6




         (f) "Disinterested  Director" means, with respect to each Proceeding in
respect  of  which  indemnification  is  sought  hereunder,  a  director  of the
Corporation who is not and was not a party to such Proceeding.

         Section 2.  Indemnification  of Officers.  Subject to the  operation of
Section 4 of this  Article  VII,  each  Officer  shall be  indemnified  and held
harmless by the  Corporation  to the fullest  extent  authorized  by the General
Corporation Law of the State of Delaware, as the same exists or may hereafter be
amended  (but in the case of any such  amendment,  only to the extent  that such
amendment permits the Corporation to provide broader indemnification rights than
such law permitted the Corporation to provide prior to such  amendment)  against
any and all Expenses, judgments, penalties, fines and amounts reasonably paid in
settlement  that are  incurred by such  Officer or on such  Officer's  behalf in
connection  with any threatened,  pending or completed  Proceeding or any claim,
issue or matter  therein,  which such Officer is, or is threatened to be made, a
party to or participant in by reason of such Officer's Corporate Status, if such
Officer acted in good faith and in a manner such Officer reasonably  believed to
be in or not opposed to the best interests of the Corporation  and, with respect
to any  criminal  proceeding,  has no  reasonable  cause to  believe  his or her
conduct was unlawful.  The rights of indemnification  provided by this Section 2
shall  continue as to an Officer after he or she has ceased to be an Officer and
shall inure to the benefit of his or her heirs,  executors,  administrators  and
personal  representatives.  Notwithstanding the foregoing, the Corporation shall
indemnify any Officer  seeking  indemnification  in connection with a Proceeding
initiated by such Officer only if such Proceeding was authorized by the Board of
Directors of the Corporation.

         Section 3.  Indemnification  of Non-Officer  Employees.  Subject to the
operation of Section 4 of this Article VII,  each  Non-Officer  Employee may, in
the discretion of the Board of Directors of the  Corporation,  be indemnified by
the Corporation to the fullest extent authorized by the General  Corporation Law
of the State of Delaware,  as the same exists or may  hereafter be amended (but,
in the  case of any such  amendment,  only to the  extent  that  such  amendment
permits the Corporation to provide broader  indemnification rights than such law
permitted the Corporation to provide prior to such amendment) against any or all
Expenses, judgments,  penalties, fines and amounts reasonably paid in settlement
that are incurred by such Non-Officer Employee or on such Non-Officer Employee's
behalf in connection with any threatened,  pending or completed  Proceeding,  or
any claim,  issue or matter  therein which such  Non-Officer  Employee is, or is
threatened  to  be  made,  a  party  to or  participant  in by  reason  of  such
non-officer  Employee's  Corporate Status, if such Non-Officer Employee acted in
good faith and in a manner such Non-Officer  Employee  reasonably believed to be
in or not opposed to the best interests of the Corporation,  and with respect to
any criminal  proceeding,  had no reasonable cause to believe his or her conduct
was  unlawful.  The rights of  indemnification  provided by this Section 3 shall
continue  as to a  Non-Officer  Employee  after  he or she  has  ceased  to be a
Non-Officer  Employee  and  shall  inure  to the  benefit  of his or her  heirs,
personal  representatives,  executors and  administrators.  Notwithstanding  the
foregoing,  the  Corporation  may indemnify  any  Non-Officer  Employee  seeking
indemnification  in connection with a Proceeding  initiated by such  Non-Officer




                                       7




Employee only if such Proceeding was authorized by the Board of Directors of the
Corporation.

         Section 4. Good Faith.  Unless ordered by a court,  no  indemnification
shall be provided pursuant to this Article VII to an Officer or to a Non-Officer
Employee unless a  determination  shall have been made that such person acted in
good  faith and in a manner  such  person  reasonably  believed  to be in or not
opposed  to the best  interests  of the  Corporation  and,  with  respect to any
criminal  Proceeding,  such person had no reasonable cause to believe his or her
conduct was unlawful. Such determination shall be made by (a) a majority vote of
the  Disinterested  Directors,  even  though  less than a quorum of the Board of
Directors, (b) if there are no such Disinterested Directors, or if a majority of
Disinterested  Directors  so direct by  independent  legal  counsel in a written
opinion, or (c) by the stockholders of the Corporation.

         Section  5.   Advancement  of  Expenses  to  Officers  Prior  to  Final
Disposition. The Corporation shall advance all Expenses incurred by or on behalf
of any  Officer in  connection  with any  Proceeding  in which  such  Officer is
involved by reason of such Officer's  Corporate Status within ten days after the
receipt by the  Corporation  of a  statement  or  statements  from such  Officer
requesting such advance or advances from time to time, whether prior to or after
final  disposition  of such  Proceeding.  Such  statement  or  statements  shall
reasonably  evidence the Expenses incurred by such Officer and shall be preceded
or  accompanied  by an  undertaking by or on behalf of such Officer to repay any
Expenses so advanced if it shall  ultimately be determined  that such Officer is
not entitled to be indemnified against such Expenses.

         Section 6.  Advancement of Expenses to Non-Officer  Employees  Prior to
Final  Disposition.  The  Corporation  may,  in the  discretion  of the Board of
Directors  of the  Corporation,  advance any or all  Expenses  incurred by or on
behalf of any  Non-Officer  Employee in connection  with any Proceeding in which
such Non-Officer  Employee is involved by reason of such Non-Officer  Employee's
Corporate  Status  upon  the  receipt  by  the  Corporation  of a  statement  or
statements from such  Non-Officer  Employee  requesting such advance or advances
from time to time,  whether prior to or after  disposition  of such  Proceeding.
Such statement or statements shall reasonably  evidence the Expenses incurred by
such Non-Officer Employee and shall be preceded or accompanied by an undertaking
by or on behalf of such  Non-Officer  Employee to repay any Expenses so advanced
if it shall  ultimately  be  determined  that such  Non-Officer  Employee is not
entitled to be indemnified against such Expenses.

         Section 7. Contractual  Nature of Rights.  The foregoing  provisions of
this Article VII shall be deemed to be a contract  between the  Corporation  and
each Officer and  Non-Officer  Employee who serves in such  capacity at any time
while this  Article  VII is in effect,  and any repeal or  modification  thereof
shall not affect any rights or  obligations  then  existing  with respect to any
state of facts then or  heretofore  existing  or any  Proceeding  heretofore  or
thereafter  brought based in whole or in part upon any such state of facts. If a
claim for  indemnification or advancement of Expenses hereunder by an Officer or
Non-Officer




                                       8




Employee  is not paid in full by the  Corporation  within  (a) 60 days after the
Corporation's  receipt of a written  claim for  indemnification,  or (b) 10 days
after the  Corporation's  receipt of  documentation of Expenses and the required
undertaking,  such Officer or  Non-Officer  Employee may at any time  thereafter
bring suit against the  Corporation  or recover the unpaid  amount of the claim,
and if  successful  in whole or in part,  such Officer or  Non-Officer  Employee
shall also be entitled to be paid the expenses of  prosecuting  such claim.  The
failure of the  Corporation  (including  its Board of Directors or any committee
thereof,  independent  legal counsel,  or  stockholders) to make a determination
concerning the permissibility of such indemnification or advancement of Expenses
under this Article VII shall not be a defense to the action and shall not create
a presumption that such indemnification or advancement is not permissible.

         Section 8. Non-Exclusivity of Rights. The rights to indemnification and
advancement  of Expenses set forth in this Article VII shall not be exclusive of
any other right which any Officer or Non-Officer  Employee may have or hereafter
acquire  under any statute,  provision  of this  Certificate  of  Incorporation,
agreement, vote of stockholders or Disinterested Directors or otherwise.

         Section 9. Insurance.  The Corporation may maintain  insurance,  at its
expense,  to protect itself and any Officer or Non-Officer  Employee against any
liability of any character  asserted  against or incurred by the  Corporation or
any such  Officer or  Non-Officer  Employee or arising out of any such  person's
Corporate  Status,  whether  or not the  Corporation  would  have  the  power to
indemnify such person against such liability  under the General  Corporation Law
of the State of Delaware or the provisions of this Article VII.

                                  ARTICLE VIII

                             LIMITATION OF LIABILITY
                             -----------------------

         A Director of the  Corporation  shall not be  personally  liable to the
Corporation  or its  stockholders  for monetary  damages for breach of fiduciary
duty as a Director,  except for liability  (i) for any breach of the  Director's
duty of  loyalty  to the  Corporation  or its  stockholders,  (ii)  for  acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation  of  law,  (iii)  under  Section  174 of the  DGCL  or  (iv)  for  any
transaction from which the Director derived an improper personal benefit. If the
DGCL is amended after the effective date of this Certificate of Incorporation to
authorize   corporate  action  further  eliminating  or  limiting  the  personal
liability of  Directors,  then the  liability  of a Director of the  Corporation
shall be eliminated or limited to the fullest  extent  permitted by the DGCL, as
so amended.

         Any repeal or  modification  of this  Article VIII by either of (i) the
stockholders  of the  Corporation  or (ii) an amendment  to the DGCL,  shall not
adversely affect any right or protection  existing at the time of such repeal or
modification with respect to any acts or



                                       9




omissions  occurring before such repeal or modification of a person serving as a
Director at the time of such repeal or modification.


                                   ARTICLE IX

                               AMENDMENT OF BYLAWS
                               -------------------

         Section 1.  Amendment by Directors
         
         In furtherance and not in limitation of the powers conferred by statute
and subject to the terms of any series of  Preferred  Stock  (provided  that any
shares of such series are issued and outstanding), the Board of Directors of the
Corporation is expressly  authorized to make,  alter or repeal the Bylaws of the
Corporation.

         Section 2.  Amendment by Stockholders

         Subject to the terms of any series of Preferred  Stock  (provided  that
any  shares of such  series  are  issued  and  outstanding),  the  Bylaws of the
Corporation may be amended or repealed at any annual meeting of stockholders, or
special meeting of stockholders called for such purpose, by the affirmative vote
of at least  two-thirds of the total votes eligible to be cast on such amendment
or repeal by  holders  of  voting  stock,  voting  together  as a single  class;
provided,  however,  that, subject to the terms of any series of Preferred Stock
(provided  that any shares of such  series are issued and  outstanding),  if the
Board of Directors recommends that stockholders approve such amendment or repeal
at such meeting of stockholders, such amendment or repeal shall only require the
affirmative  vote of a majority of the total  votes  eligible to be cast on such
amendment  or repeal by holders of voting  stock,  voting  together  as a single
class.

                                    ARTICLE X

                    AMENDMENT OF CERTIFICATE OF INCORPORATION
                    -----------------------------------------

         Subject to the terms of any series of Preferred  Stock  (provided  that
any shares of such series are issued and outstanding),  the Corporation reserves
the right to amend or repeal this Certificate of Incorporation in the manner now
or hereafter  prescribed by statute and this Certificate of  Incorporation,  and
all  rights  conferred  upon  stockholders  herein are  granted  subject to this
reservation.  No amendment or repeal of this Certificate of Incorporation  shall
be made unless the same is first approved by the Board of Directors  pursuant to
a resolution adopted by the Board of Directors in accordance with Section 242 of
the DGCL, and, except as otherwise provided by law,  thereafter  approved by the
stockholders.  Subject to the terms of any series of Preferred  Stock  (provided
that any shares of such series are issued and outstanding), whenever any vote of
the holders of voting  stock is  required,  and in addition to any other vote of
holders of voting stock that is required by this Certificate of Incorporation or
by law,  the  affirmative  vote of a majority of the total votes  eligible to be
cast by holders of voting stock with respect to such amendment or repeal, voting
together as a single class, at a duly constituted meeting of stockholders called
expressly for such purpose  shall be required to amend or repeal any  provisions
of this Certificate of Incorporation;  provided,  however,  that, subject to the
terms of any series of Preferred  Stock (provided that any shares of such series
are issued and  outstanding),  the affirmative  vote of not less than 80% of the
total votes  eligible to be cast by holders of




                                       10




voting  stock,  voting  together a single  class,  shall be required to amend or
repeal any of the provisions of Article X of this Certificate of Incorporation.

         The name of the Incorporator of the Corporation is J. Benjamin English,
Esquire and his  business  address is 707 East Main Street,  11th Floor,  in the
City of Richmond, Virginia 23219.


                                  /s/ J. Benjamin English
                                  --------------------------------------
                                  Incorporator
                                  J. Benjamin English



                                                                     EXHIBIT 3.2

                                     BYLAWS

                                       OF

                              PERARDUA CORPORATION

                                    ARTICLE I
                                    ---------
                                  Stockholders
                                  ------------

         SECTION 1. Annual Meeting.  The annual meeting of stockholders shall be
held at the hour,  date and place  within or without the United  States which is
fixed by the majority of the Board of Directors,  the Chairman of the Board,  if
one is elected, or the President, which time, date and place may subsequently be
changed at any time by vote of the Board of Directors.  If no annual meeting has
been held for a period of thirteen  months after the  Corporation's  last annual
meeting of stockholders, a special meeting in lieu thereof may be held, and such
special  meeting shall have, for the purposes of these Bylaws or otherwise,  all
the force and effect of an annual meeting.  Any and all references  hereafter in
these  Bylaws to an annual  meeting or annual  meetings  also shall be deemed to
refer to any special meeting(s) in lieu thereof.

         SECTION 2. Matters to be Considered at Annual  Meetings.  At any annual
meeting of  stockholders  or any  special  meeting in lieu of annual  meeting of
stockholders (the "Annual Meeting"),  only such business shall be conducted, and
only such  proposals  shall be acted upon, as shall have been  properly  brought
before such Annual  Meeting.  To be  considered  as properly  brought  before an
Annual  Meeting,  business must be: (a) specified in the notice of meeting,  (b)
otherwise  properly  brought  before the meeting by, or at the direction of, the
Board of Directors,  or (c) otherwise properly brought before the meeting by any
holder of record  (both as of the time  notice of such  proposal is given by the
stockholder  as set forth below and as of the record date for the Annual Meeting
in question) of any shares of capital stock of the Corporation  entitled to vote
at such Annual  Meeting who  complies  with the  requirements  set forth in this
Section 2.

         In addition to any other  applicable  requirements,  for business to be
properly  brought  before an Annual  Meeting by a  stockholder  of record of any
shares  of  capital  stock  entitled  to  vote  at  such  Annual  Meeting,  such
stockholder  shall:  (i) give timely notice as required by this Section 2 to the
Secretary  of the  Corporation  and (ii) be present at such  meeting,  either in
person  or by a  representative.  For the first  Annual  Meeting  following  the
initial  public  offering of common stock of the  Corporation,  a  stockholder's
notice  shall be timely if  delivered  to, or  mailed to and  received  by,  the
Corporation  at its  principal  executive  office  not  later  than the close of
business  on the later of (A) the 75th day prior to the  scheduled  date of such
Annual  Meeting  or  (B)  the  15th  day  following  the  day  on  which  public
announcement  of






the date of such of such Annual  Meeting is first made by the  Corporation.  For
all  subsequent  Annual  Meetings,  a  stockholder's  notice  shall be timely if
delivered  to, or mailed to and received by, the  Corporation  at its  principal
executive  office  not less  than 75 days nor  more  than 120 days  prior to the
anniversary date of the immediately  preceding Annual Meeting (the  "Anniversary
Date"); provided,  however, that in the event the Annual Meeting is scheduled to
be held on a date more than 30 days before the Anniversary  Date or more than 60
days after the  Anniversary  Date,  a  stockholder's  notice  shall be timely if
delivered  to, or mailed to and received by, the  Corporation  at its  principal
executive  office not later than the close of  business  on the later of (A) the
75th day prior to the scheduled  date of such Annual Meeting or (B) the 15th day
following  the day on  which  public  announcement  of the  date of such  Annual
Meeting is first made by the Corporation.

         For purposes of these Bylaws,  "public  announcement"  shall mean:  (i)
disclosure in a press release reported by the Dow Jones News Service, Associated
Press or comparable national news service, (ii) a report or other document filed
publicly  with  the  Securities  and  Exchange  Commission  (including,  without
limitation,  a Form 8-K),  or (iii) a letter or report sent to  stockholders  of
record of the Corporation at the time of the mailing of such letter or report.

         A  stockholder's  notice  to the  Secretary  shall set forth as to each
matter proposed to be brought before an Annual Meeting:  (i) a brief description
of the business the stockholder  desires to bring before such Annual Meeting and
the reasons for conducting such business at such Annual  Meeting,  (ii) the name
and address,  as they appear on the  Corporation's  stock transfer books, of the
stockholder proposing such business, (iii) the class and number of shares of the
Corporation's capital stock beneficially owned by the stockholder proposing such
business,  (iv) the names and addresses of the beneficial owners, if any, of any
capital stock of the Corporation  registered in such  stockholder's name on such
books,  and the class and number of shares of the  Corporation's  capital  stock
beneficially  owned by such  beneficial  owners,  (v) the names and addresses of
other stockholders  known by the stockholder  proposing such business to support
such proposal,  and the class and number of shares of the Corporation's  capital
stock  beneficially  owned by such  other  stockholders,  and (vi) any  material
interest of the stockholder proposing to bring such business before such meeting
(or any  other  stockholders  known  to be  supporting  such  proposal)  in such
proposal.

         If the Board of Directors or a designated  committee thereof determines
that any  stockholder  proposal was not made in a timely  fashion in  accordance
with the  provisions  of this  Section 2 or that the  information  provided in a
stockholder's  notice  does not  satisfy the  information  requirements  of this
Section 2 in any material  respect,  such  proposal  shall not be presented  for
action at the Annual Meeting in question.  If neither the Board of Directors nor
such  committee  makes a  determination  as to the  validity of any  stockholder
proposal  in the manner set forth  above,  the  presiding  officer of the Annual
Meeting shall determine whether the stockholder  proposal was made in accordance
with the terms of this Section 2. If the presiding  officer  determines that any
stockholder  proposal was not made in a timely  fashion in  accordance  with the
provisions of this Section 2 or that the information provided in a stockholder's
notice does not satisfy the  information  requirements  of this Section 2 in any




                                       2



material respect,  such proposal shall not be presented for action at the Annual
Meeting in question.  If the Board of Directors,  a designated committee thereof
or the presiding  officer  determines  that a  stockholder  proposal was made in
accordance with the requirements of this Section 2, the presiding  officer shall
so declare at the Annual  Meeting and ballots  shall be provided  for use at the
meeting with respect to such proposal.

         Notwithstanding  the foregoing  provisions of this Bylaw, a stockholder
shall also comply with all applicable  requirements  of the Securities  Exchange
Act of 1934,  as  amended  (the  "Exchange  Act") and the rules and  regulations
thereunder  with respect to the matters set forth in this Bylaw,  and nothing in
this  Bylaw  shall be deemed to affect  any  rights of  stockholders  to request
inclusion of proposals in the  Corporation's  proxy  statement  pursuant to Rule
14a-8 under the Exchange Act.

         SECTION 3. Special  Meetings.  Except as otherwise  required by law and
subject to the rights,  if any, of the holders of any series of Preferred Stock,
special  meetings of the  stockholders  of the Corporation may be called only by
the Board of Directors pursuant to a resolution approved by the affirmative vote
of a majority of the Directors then in office.

         SECTION 4. Matters to be  Considered  at Special  Meetings.  Only those
matters set forth in the notice of the  special  meeting  may be  considered  or
acted  upon at a special  meeting of  stockholders  of the  Corporation,  unless
otherwise provided by law.

         SECTION 5. Notice of Meetings;  Adjournments.  A written  notice of all
Annual  Meetings  stating the hour, date and place of such Annual Meetings shall
be given by the Secretary or an Assistant  Secretary (or other person authorized
by these  Bylaws or by law) not less  than 10 days nor more than 60 days  before
the Annual  Meeting,  to each  stockholder  entitled to vote thereat and to each
stockholder who, by law or under the Certificate of Incorporation or under these
Bylaws,  is  entitled to such  notice,  by  delivering  such notice to him or by
mailing it,  postage  prepaid,  addressed to such  stockholder at the address of
such stockholder as it appears on the  Corporation's  stock transfer books. Such
notice  shall be deemed to be delivered  when hand  delivered to such address or
deposited in the mail so addressed, with postage prepaid.

         Notice of all special  meetings of  stockholders  shall be given in the
same manner as provided for Annual  Meetings,  except that the written notice of
all special  meetings  shall state the purpose or purposes for which the meeting
has been called.

         Notice of an Annual Meeting or special meeting of stockholders need not
be given to a  stockholder  if a written  waiver  of notice is signed  before or
after such  meeting by such  stockholder  or if such  stockholder  attends  such
meeting,  unless such attendance was for the express purpose of objecting at the
beginning of the meeting to the transaction of any business  because the meeting
was not lawfully  called or convened.  Neither the business to be transacted at,
nor the purpose of, any Annual Meeting or special meeting of  stockholders  need
be specified in any written waiver of notice.




                                       3




         The Board of  Directors  may  postpone and  reschedule  any  previously
scheduled  Annual Meeting or special meeting of stockholders and any record date
with respect thereto, regardless of whether any notice or public disclosure with
respect to any such meeting has been sent or made  pursuant to Section 2 of this
Article I or Section 3 of Article II hereof or otherwise.  In no event shall the
public  announcement  of an  adjournment,  postponement  or  rescheduling of any
previously scheduled meeting of stockholders  commence a new time period for the
giving of a  stockholder's  notice under Section 2 of Article I and Section 3 of
Article II of these Bylaws.

         When any meeting is  convened,  the  presiding  officer may adjourn the
meeting if (a) no quorum is present for the  transaction  of  business,  (b) the
Board of Directors  determines  that  adjournment is necessary or appropriate to
enable  the  stockholders  to  consider  fully  information  which  the Board of
Directors  determines  has not been made  sufficiently  or timely  available  to
stockholders,  or (c) the Board of  Directors  determines  that  adjournment  is
otherwise in the best interests of the  Corporation.  When any Annual Meeting or
special  meeting of  stockholders  is adjourned to another hour,  date or place,
notice need not be given of the adjourned  meeting other than an announcement at
the  meeting at which the  adjournment  is taken of the hour,  date and place to
which the meeting is adjourned;  provided,  however,  that if the adjournment is
for more than 30 days,  or if after the  adjournment  a new record date is fixed
for the adjourned  meeting,  notice of the  adjourned  meeting shall be given to
each stockholder of record entitled to vote thereat and each stockholder who, by
law or under the Corporation's  Certificate of Incorporation or these Bylaws, is
entitled to such notice.

         SECTION 6. Quorum. The holders of shares of voting stock representing a
majority of the voting power of the  outstanding  shares of voting stock issued,
outstanding  and entitled to vote at a meeting of  stockholders,  represented in
person or by proxy at such meeting,  shall constitute a quorum; but if less than
a quorum is present at a meeting,  the holders of voting  stock  representing  a
majority of the voting power present at the meeting or the presiding officer may
adjourn the meeting from time to time,  and the meeting may be held as adjourned
without  further  notice,  except as provided in Section 5 of this Article I. At
such  adjourned  meeting  at which a quorum  is  present,  any  business  may be
transacted  which  might  have been  transacted  at the  meeting  as  originally
noticed.  The stockholders present at a duly constituted meeting may continue to
transact business until  adjournment,  notwithstanding  the withdrawal of enough
stockholders to leave less than a quorum.

         SECTION 7.  Voting and  Proxies.  Stockholders  shall have one vote for
each share of stock  entitled to vote owned by them of record  according  to the
books  of  the  Corporation,   unless  otherwise  provided  by  law  or  by  the
Corporation's  Certificate  of  Incorporation.  Stockholders  may vote either in
person or by  written  proxy,  but no proxy  shall be voted or acted  upon after
three  years  from its date,  unless  the proxy  provides  for a longer  period.
Proxies  shall be filed with the  Secretary  of the meeting  before being voted.
Except as otherwise  limited  therein or as otherwise  provided by law,  proxies
shall entitle the persons  authorized thereby to vote at any adjournment of such
meeting,  but they shall not be valid after final adjournment of such meeting. A
proxy with  respect to stock  held in the name of two or more  persons  shall be
valid if  executed  by or on behalf of any one of them unless at or prior to



                                       4




the exercise of the proxy the Corporation  receives a specific written notice to
the contrary  from any one of them. A proxy  purporting  to be executed by or on
behalf  of a  stockholder  shall be deemed  valid,  and the  burden  of  proving
invalidity shall rest on the challenger.

         SECTION 8.  Action at  Meeting.  When a quorum is  present,  any matter
before any meeting of stockholders shall be decided by the vote of a majority of
the voting power of shares of voting stock,  present in person or represented by
proxy at such meeting and entitled to vote on such matter, except where a larger
vote is required by law, by the Certificate of Incorporation or by these Bylaws.
Any election by  stockholders  shall be  determined  by a plurality of the votes
cast,  except  where a larger vote is required  by law,  by the  Certificate  of
Incorporation  or by  these  Bylaws.  The  Corporation  shall  not  directly  or
indirectly  vote  any  shares  of its own  stock;  provided,  however,  that the
Corporation may vote shares which it holds in a fiduciary capacity to the extent
permitted by law.

         SECTION 9. Stockholder  Lists. The Secretary or an Assistant  Secretary
(or the Corporation's  transfer agent or other person authorized by these Bylaws
or by law) shall prepare and make, at least 10 days before every Annual  Meeting
or special meeting of stockholders, a complete list of the stockholders entitled
to vote at the meeting,  arranged in alphabetical order, and showing the address
of each  stockholder  and the  number of shares  registered  in the name of each
stockholder.  Such list shall be open to the examination of any stockholder, for
any purpose germane to the meeting, during ordinary business hours, for a period
of at least 10 days  prior to the  meeting,  either at a place  within  the city
where the meeting is to be held, which place shall be specified in the notice of
the meeting,  or, if not so  specified,  at the place where the meeting is to be
held.  The list shall also be produced  and kept at the hour,  date and place of
the  meeting  during  the  whole  time  thereof,  and  may be  inspected  by any
stockholder who is present.

         SECTION 10.  Presiding  Officer.  The Chairman of the Board,  if one is
elected,  or if not elected or in his absence,  the President,  shall preside at
all Annual  Meetings  or special  meetings  of  stockholders  and shall have the
power,  among other things, to adjourn such meeting at any time and from time to
time,  subject to Sections 5 and 6 of this  Article I. The order of business and
all other  matters of  procedure  at any  meeting of the  stockholders  shall be
determined by the presiding officer.

         SECTION  11.  Voting  Procedures  and  Inspectors  of  Elections.   The
Corporation  shall,  in advance of any meeting of  stockholders,  appoint one or
more  inspectors to act at the meeting and make a written  report  thereof.  The
Corporation may designate one or more persons as alternate inspectors to replace
any inspector who fails to act. If no inspector or alternate is able to act at a
meeting  of  stockholders,  the  presiding  officer  shall  appoint  one or more
inspectors  to act at the  meeting.  Any  inspector  may,  but need  not,  be an
officer, employee or agent of the Corporation.  Each inspector,  before entering
upon the  discharge  of his duties,  shall take and sign an oath  faithfully  to
execute the duties of inspector  with strict  impartiality  and according to the
best of his or her  ability.  The  inspectors  shall  perform such duties as are
required by the General  Corporation  Law of the State of  Delaware,  as amended
from  time to time,  including  the  counting  of all  votes  and  ballots.  The
inspectors  may  appoint




                                       5



or retain other persons or entities to assist the inspectors in the  performance
of  the  duties  of  the  inspectors.  The  presiding  officer  may  review  all
determinations  made by the  inspectors,  and in so doing the presiding  officer
shall be entitled to exercise his or her sole judgment and  discretion and he or
she  shall  not be bound by any  determinations  made by the  inspector(s).  All
determinations  by the inspector(s)  and, if applicable,  the presiding  officer
shall be subject to further review by any court of competent jurisdiction.


                                   ARTICLE II
                                   ----------
                                    Directors
                                    ---------

         SECTION 1. Powers. The business and affairs of the Corporation shall be
managed by or under the direction of the Board of Directors  except as otherwise
provided by the Certificate of Incorporation or required by law.

         SECTION 2. Number and Terms.  The number and terms of  Directors of the
Corporation  shall  be in  accordance  with  the  Corporation's  Certificate  of
Incorporation.

         SECTION 3. Director Nominations. Nominations of candidates for election
as directors of the  Corporation  at any Annual Meeting may be made only (a) by,
or at the  direction  of, a  majority  of the Board of  Directors  or (b) by any
holder of record (both as of the time notice of such  nomination is given by the
stockholder  as set forth below and as of the record date for the Annual Meeting
in question) of any shares of the capital stock of the  Corporation  entitled to
vote at such Annual  Meeting who  complies  with the timing,  informational  and
other  requirements  set forth in this Section 3. Any  stockholder  who seeks to
make such a nomination  or his  representative  must be present in person at the
Annual  Meeting.  Only persons  nominated in accordance  with the procedures set
forth in this Section 3 shall be eligible for election as directors at an Annual
Meeting.

         Nominations,  other  than those  made by, or at the  direction  of, the
Board of  Directors,  shall be made  pursuant to timely notice in writing to the
Secretary  of the  Corporation  as set  forth in this  Section  3. For the first
Annual  Meeting  following  the initial  public  offering of common stock of the
Corporation,  a stockholder's  notice shall be timely if delivered to, or mailed
to and received by, the Corporation at its principal  executive office not later
than  the  close of  business  on the  later  of (A) the  75th day  prior to the
scheduled  date of such Annual  Meeting or (B) the 15th day following the day on
which public  announcement  of the date of such Annual  Meeting is first made by
the  Corporation.  For all subsequent  Annual Meetings,  a stockholder's  notice
shall be timely if delivered  to, or mailed to and received by, the  Corporation
at its principal  executive  office not less than 75 days nor more than 120 days
prior to the Anniversary Date; provided,  however,  that in the event the Annual
Meeting  is  scheduled  to be  held on a date  more  than  30  days  before  the
Anniversary   Date  or  more  than  60  days  after  the  Anniversary   Date,  a
stockholder's notice shall be timely if delivered to, or mailed and received by,
the  Corporation at its principal  executive  office not later than the close of
business  on the later of (i) the 75th day prior to the  scheduled  date of such
Annual  Meeting  or



                                       6




(ii) the 15th day following the day on which public  announcement of the date of
such Annual Meeting is first made by the Corporation.

         A  stockholder's  notice  to the  Secretary  shall set forth as to each
person whom the stockholder  proposes to nominate for election or re-election as
a director:  (i) the name, age,  business address and residence  address of such
person,  (ii) the principal  occupation or employment of such person,  (iii) the
class  and  number  of  shares  of the  Corporation's  capital  stock  which are
beneficially  owned by such person on the date of such stockholder  notice,  and
(iv)  the  consent  of each  nominee  to  serve  as a  director  if  elected.  A
stockholder's  notice  to  the  Secretary  shall  further  set  forth  as to the
stockholder giving such notice: (i) the name and address,  as they appear on the
Corporation's  stock transfer books,  of such  stockholder and of the beneficial
owners  (if  any)  of  the  Corporation's   capital  stock  registered  in  such
stockholder's  name and the name and address of other stockholders known by such
stockholder  to be  supporting  such  nominee(s),  (ii) the class and  number of
shares of the Corporation's capital stock which are held of record, beneficially
owned or represented by proxy by such stockholder and by any other  stockholders
known by such  stockholder to be supporting  such  nominee(s) on the record date
for the  Annual  Meeting  in  question  (if such date  shall then have been made
publicly  available) and on the date of such  stockholder's  notice, and (iii) a
description of all arrangements or  understandings  between such stockholder and
each  nominee and any other  person or persons  (naming  such person or persons)
pursuant  to  which  the  nomination  or  nominations  are to be  made  by  such
stockholder.

         If the Board of Directors or a designated  committee thereof determines
that any stockholder nomination was not timely made in accordance with the terms
of this Section 3 or that the  information  provided in a  stockholder's  notice
does  not  satisfy  the  informational  requirements  of this  Section  3 in any
material  respect,  then such  nomination  shall not be considered at the Annual
Meeting in question.  If neither the Board of Directors nor such committee makes
a  determination  as to whether a  nomination  was made in  accordance  with the
provisions of this Section 3, the presiding  officer of the Annual Meeting shall
determine  whether a nomination was made in accordance with such provisions.  If
the presiding officer determines that any stockholder  nomination was not timely
made in  accordance  with the terms of this  Section  3 or that the  information
provided  in  a  stockholder's   notice  does  not  satisfy  the   informational
requirements  of this Section 3 in any material  respect,  then such  nomination
shall not be  considered  at the  Annual  Meeting in  question.  If the Board of
Directors,  a designated  committee thereof or the presiding officer  determines
that a nomination  was made in accordance  with the terms of this Section 3, the
presiding  officer  shall so declare at the Annual  Meeting and ballots shall be
provided for use at the meeting with respect to such nominee.

         Notwithstanding  anything to the contrary in the second sentence of the
second paragraph of this Section 3, in the event that the number of directors to
be elected to the Board of Directors of the  Corporation  is increased and there
is no public  announcement  by the  Corporation  naming all of the  nominees for
director or specifying the size of the increased  Board of Directors at least 75
days prior to the  Anniversary  Date, a  stockholder's  notice  required by this
Section 3 shall also be considered timely, but only with respect to nominees




                                       7



for any new  positions  created  by such  increase,  if  such  notice  shall  be
delivered  to, or mailed to and received by, the  Corporation  at its  principal
executive  office not later than the close of business on the 15th day following
the day on which such public announcement is first made by the Corporation.

         No person  shall be elected by the  stockholders  as a Director  of the
Corporation unless nominated in accordance with the procedures set forth in this
Section.  Election of  Directors  at the annual  meeting  need not be by written
ballot, unless otherwise provided by the Board of Directors or presiding officer
at such annual meeting.  If written ballots are to be used,  ballots bearing the
names of all the persons who have been  nominated  for  election as Directors at
the annual  meeting in accordance  with the procedures set forth in this Section
shall be provided for use at the annual meeting.

         SECTION 4. Qualification.  No  Director  need be a  stockholder  of the
Corporation.

         SECTION 5. Vacancies.   Except  as  otherwise  fixed  pursuant  to  the
provisions of Article IV of the Certificate of  Incorporation of the Corporation
relating to the rights of the holders of any series of preferred  stock to elect
Directors,  any and all vacancies in the Board of Directors,  however occurring,
including,  without limitation, by reason of an increase in size of the Board of
Directors, or the death, resignation, disqualification or removal of a Director,
shall be filled  solely by the  affirmative  vote of a majority of the remaining
Directors then in office,  even if less than a quorum of the Board of Directors.
Any Director  appointed in  accordance  with the preceding  sentence  shall hold
office for the remainder of the full term of the class of Directors in which the
new  directorship  was created or the vacancy occurred and until such Director's
successor shall have been duly elected and qualified or until his or her earlier
resignation or removal.  When the number of Directors is increased or decreased,
the  Board of  Directors  shall  determine  the  class or  classes  to which the
increased  or  decreased  number of Directors  shall be  apportioned;  provided,
however,  that no decrease in the number of Directors  shall shorten the term of
any incumbent Director. In the event of a vacancy in the Board of Directors, the
remaining  Directors,  except as  otherwise  provided by law,  may  exercise the
powers of the full Board of Directors until the vacancy is filled.

         SECTION 6. Removal.  Directors may be removed from office in the manner
provided in the Corporation's Certificate of Incorporation.

         SECTION 7. Resignation.  A  Director  may  resign at any time by giving
written notice to the Chairman of the Board, if one is elected, the President or
the  Secretary.  A  resignation  shall be  effective  upon  receipt,  unless the
resignation otherwise provides.

         SECTION 8. Regular Meetings. The regular annual meeting of the Board of
Directors shall be held,  without notice other than this Bylaw, on the same date
and at the same place as the Annual Meeting  following the close of such meeting
of stockholders. Other regular meetings of the Board of Directors may be held at
such hour,  date and place as the Board of Directors may by resolution from time
to time determine without notice other than such resolution.



                                       8



         SECTION 9. Special Meetings. Special meetings of the Board of Directors
may be called,  orally or in writing,  by or at the request of a majority of the
Directors,  the Chairman of the Board, if one is elected, or the President.  The
person  calling any such special  meeting of the Board of Directors  may fix the
hour, date and place thereof.

         SECTION 10. Notice of Meetings.  Notice of the hour,  date and place of
all special  meetings of the Board of Directors  shall be given to each Director
by the Secretary or an Assistant  Secretary,  or in case of the death,  absence,
incapacity or refusal of such persons,  by the Chairman of the Board,  if one is
elected,  or the President or such other  officer  designated by the Chairman of
the Board, if one is elected, or the President. Notice of any special meeting of
the Board of Directors shall be given to each Director in person,  by telephone,
or  by  telex,   telecopy,   telegram,  or  other  written  form  of  electronic
communication,  sent to his  business  or home  address,  at  least  24 hours in
advance of the  meeting,  or by written  notice  mailed to his  business or home
address,  at least 48 hours in  advance of the  meeting.  Such  notice  shall be
deemed  to be  delivered  when  hand  delivered  to such  address,  read to such
Director by telephone,  deposited in the mail so addressed, with postage thereon
prepaid if mailed,  dispatched or transmitted if telexed or telecopied,  or when
delivered to the telegraph company if sent by telegram.

         When any Board of  Directors  meeting,  either  regular or special,  is
adjourned for 30 days or more, notice of the adjourned meeting shall be given as
in the case of an original meeting. It shall not be necessary to give any notice
of the hour, date or place of any meeting  adjourned for less than 30 days or of
the business to be transacted thereat, other than an announcement at the meeting
at which  such  adjournment  is taken of the  hour,  date and place to which the
meeting is adjourned.

         A  written  waiver  of notice  signed  before  or after a meeting  by a
Director  and  filed  with the  records  of the  meeting  shall be  deemed to be
equivalent to notice of the meeting.  The  attendance of a Director at a meeting
shall  constitute  a waiver of notice of such  meeting,  except where a Director
attends a meeting for the express  purpose of objecting at the  beginning of the
meeting to the transaction of any business  because such meeting is not lawfully
called or convened.  Except as otherwise  required by law, by the Certificate of
Incorporation of the Corporation or by these Bylaws,  neither the business to be
transacted at, nor the purpose of, any meeting of the Board of Directors need be
specified in the notice or waiver of notice of such meeting.

         SECTION  11.  Quorum.  At any  meeting  of the  Board of  Directors,  a
majority  of the  Directors  then in office  shall  constitute  a quorum for the
transaction  of business,  but if less than a quorum is present at a meeting,  a
majority of the Directors present may adjourn the meeting from time to time, and
the meeting may be held as adjourned without further notice,  except as provided
in Section 10 of this Article II. Any business which might have been  transacted
at the meeting as originally noticed may be transacted at such adjourned meeting
at which a quorum is present.




                                       9



         SECTION  12.  Action  at  Meetings.  At any  meeting  of the  Board  of
Directors at which a quorum is present,  a majority of the Directors present may
take any action on behalf of the Board of Directors,  unless otherwise  required
by law, by the  Certificate  of  Incorporation  of the  Corporation  or by these
Bylaws.

         SECTION 13. Action by Consent.  Any action  required or permitted to be
taken at any meeting of the Board of Directors may be taken without a meeting if
all members of the Board of Directors  consent thereto in writing.  Such written
consent  shall be  filed  with  the  records  of the  meetings  of the  Board of
Directors  and shall be treated  for all  purposes as a vote at a meeting of the
Board of Directors.

         SECTION 14.  Manner of  Participation.  Directors  may  participate  in
meetings of the Board of Directors by means of  conference  telephone or similar
communications  equipment by means of which all Directors  participating  in the
meeting  can hear each  other,  and  participation  in a meeting  in  accordance
herewith  shall  constitute  presence in person at such  meeting for purposes of
these Bylaws.

         SECTION 15. Committees.  The Board of Directors,  by vote of a majority
of the  Directors  then  in  office,  may  elect  from  its  number  one or more
committees,  including an Executive Committee,  a Compensation  Committee and an
Audit Committee, and may delegate thereto some or all of its powers except those
which by law, by the Certificate of Incorporation of the Corporation or by these
Bylaws may not be  delegated.  Except as the Board of  Directors  may  otherwise
determine,  any such  committee  may make rules for the conduct of its business,
but unless  otherwise  provided by the Board of Directors or in such rules,  its
business shall be conducted so far as possible in the same manner as is provided
by these Bylaws for the Board of Directors. All members of such committees shall
hold  such  offices  at the  pleasure  of the Board of  Directors.  The Board of
Directors may abolish any such committee at any time. Any committee to which the
Board of Directors  delegates  any of its powers or duties shall keep records of
its meetings and shall report its action to the Board of Directors. The Board of
Directors shall have power to rescind any action of any committee, to the extent
permitted by law, but no such rescission shall have retroactive effect.

         SECTION 16.  Compensation  of Directors.  Directors  shall receive such
compensation  for their  services  as shall be  determined  by a majority of the
Board of Directors  provided that  Directors who are serving the  Corporation as
employees and who receive  compensation  for their  services as such,  shall not
receive any salary or other  compensation for their services as Directors of the
Corporation.


                                   ARTICLE III
                                   -----------
                                    Officers
                                    --------

         SECTION 1.  Enumeration.  The officers of the Corporation shall consist
of a President,  a Treasurer,  a Secretary and such other  officers,  including,
without  limitation,  a



                                       10




Chairman of the Board of Directors  and one or more  Vice-Presidents  (including
Executive Vice Presidents or Senior Vice Presidents), Assistant Vice Presidents,
Assistant  Treasurers and Assistant  Secretaries,  as the Board of Directors may
determine.

         SECTION  2.  Election.  At the  regular  annual  meeting  of the  Board
following the annual meeting of stockholders, the Board of Directors shall elect
the President, the Treasurer and the Secretary. Other officers may be elected by
the Board of Directors at such regular  annual meeting of the Board of Directors
or at any other regular or special meeting.

         SECTION  3.  Qualification.  No  officer  need  be a  stockholder  or a
Director.  Any person may occupy more than one office of the  Corporation at any
time. Any officer may be required by the Board of Directors to give bond for the
faithful  performance of his duties in such amount and with such sureties as the
Board of Directors may determine.

         SECTION 4.  Tenure. Except as otherwise  provided by the Certificate of
Incorporation of the Corporation or by these Bylaws, each of the officers of the
Corporation  shall hold office until the regular  annual meeting of the Board of
Directors  following  the next  annual  meeting  of  stockholders  and until his
successor is elected and qualified or until his earlier resignation or removal.

         SECTION 5. Resignation. Any officer may resign by delivering his or her
written  resignation  to  the  Corporation  addressed  to the  President  or the
Secretary,  and such  resignation  shall be effective  upon receipt unless it is
specified to be effective at some other time or upon the happening of some other
event.

         SECTION 6. Removal.  Except as otherwise  provided by law, the Board of
Directors may remove any officer with or without cause by the  affirmative  vote
of a majority of the Directors  then in office;  provided,  however,  that if an
officer  is to be  removed  for  cause,  he or she  may  only be  removed  after
reasonable notice and an opportunity to be heard by the Board of Directors.

         SECTION 7. Absence  or  Disability.  In the  event  of the  absence  or
disability of any officer,  the Board of Directors may designate another officer
to act temporarily in place of such absent or disabled officer.

         SECTION 8. Vacancies.  Any  vacancy in any office may be filled for the
unexpired portion of the term by the Board of Directors.

         SECTION 9. President.   Unless  otherwise  provided  by  the  Board  of
Directors or the Certificate of Incorporation,  the President shall be the Chief
Executive Officer of the Corporation and shall,  subject to the direction of the
Board of Directors,  have general  supervision and control of the  Corporation's
business. If there is no Chairman of the Board or if he is absent, the President
shall preside, when present, at all meetings of stockholders and of the Board of
Directors.  The  President  shall have such other  powers and perform such other
duties as the Board of Directors may from time to time designate.




                                       11




         SECTION 10. Chairman of the Board. The Chairman of the Board, if one is
elected, shall preside, when present, at all meetings of the stockholders and of
the Board of  Directors.  The Chairman of the Board shall have such other powers
and shall  perform such other duties as the Board of Directors  may from time to
time designate.

         SECTION 11.  Vice  Presidents  and Assistant Vice Presidents.  Any Vice
President  (including any Executive Vice President or Senior Vice President) and
any  Assistant  Vice  President  shall have such powers and shall  perform  such
duties as the Board of Directors or the Chief Executive Officer may from time to
time designate.

         SECTION 12.  Treasurer and Assistant  Treasurers.  The Treasurer shall,
subject to the  direction of the Board of  Directors  and except as the Board of
Directors or the Chief  Executive  Officer may otherwise  provide,  have general
charge of the financial  affairs of the  Corporation  and shall cause to be kept
accurate  books of  account.  The  Treasurer  shall  have  custody of all funds,
securities, and valuable documents of the Corporation. He or she shall have such
other duties and powers as may be  designated  from time to time by the Board of
Directors or the Chief Executive Officer.

         Any Assistant  Treasurer shall have such powers and perform such duties
as the Board of Directors or the Chief  Executive  Officer may from time to time
designate.

         SECTION 13.  Secretary and Assistant  Secretaries.  The Secretary shall
record all the proceedings of the meetings of the  stockholders and the Board of
Directors (including committees of the Board) in books kept for that purpose. In
his absence from any such meeting,  a temporary  secretary chosen at the meeting
shall record the  proceedings  thereof.  The Secretary  shall have charge of the
stock ledger (which may, however,  be kept by any transfer or other agent of the
Corporation).  The Secretary shall have custody of the seal of the  Corporation,
and the Secretary,  or an Assistant Secretary,  shall have authority to affix it
to any instrument  requiring it, and, when so affixed,  the seal may be attested
by his or her signature or that of an Assistant  Secretary.  The Secretary shall
have such other duties and powers as may be designated  from time to time by the
Board of  Directors  or the  Chief  Executive  Officer.  In the  absence  of the
Secretary,   any  Assistant   Secretary  may  perform  his  or  her  duties  and
responsibilities.

         Any Assistant  Secretary shall have such powers and perform such duties
as the Board of Directors or the Chief  Executive  Officer may from time to time
designate.

         SECTION 14.  Other  Powers and Duties.  Subject to these  Bylaws and to
such limitations as the Board of Directors may from time to time prescribe,  the
officers of the Corporation  shall each have such powers and duties as generally
pertain to their respective  offices,  as well as such powers and duties as from
time to time may be conferred  by the Board of Directors or the Chief  Executive
Officer.


                                       12





                                   ARTICLE IV
                                   ----------
                                  Capital Stock
                                  -------------

         SECTION 1. Certificates of Stock. Each stockholder shall be entitled to
a certificate  of the capital stock of the  Corporation in such form as may from
time to time be prescribed by the Board of Directors.  Such certificate shall be
signed by the Chairman of the Board of Directors,  Vice Chairman of the Board of
Directors,  the  President  or a  Vice  President  and by  the  Treasurer  or an
Assistant Treasurer, or the Secretary or an Assistant Secretary. The Corporation
seal and the  signatures  by  Corporation  officers,  the transfer  agent or the
registrar may be  facsimiles.  In case any officer,  transfer agent or registrar
who has signed or whose facsimile  signature has been placed on such certificate
shall have ceased to be such officer,  transfer  agent or registrar  before such
certificate is issued,  it may be issued by the Corporation with the same effect
as if he were  such  officer,  transfer  agent or  registrar  at the time of its
issue.  Every  certificate  for  shares  of  stock  which  are  subject  to  any
restriction  on transfer and every  certificate  issued when the  Corporation is
authorized  to issue more than one class or series of stock shall  contain  such
legend with respect thereto as is required by law.

         SECTION 2.  Transfers.  Subject to any  restrictions  on  transfer  and
unless  otherwise  provided  by the Board of  Directors,  shares of stock may be
transferred  only  on the  books  of the  Corporation  by the  surrender  to the
Corporation  or its  transfer  agent  of the  certificate  theretofore  properly
endorsed or  accompanied by a written  assignment or power of attorney  properly
executed,  with transfer stamps (if necessary)  affixed,  and with such proof of
the  authenticity  of signature  as the  Corporation  or its transfer  agent may
reasonably require.

         SECTION 3. Record Holders.  Except as may otherwise be required by law,
by the Certificate of Incorporation  of the Corporation or by these Bylaws,  the
Corporation  shall be entitled  to treat the record  holder of stock as shown on
its books as the owner of such stock for all purposes,  including the payment of
dividends  and the  right  to  vote  with  respect  thereto,  regardless  of any
transfer,  pledge or other disposition of such stock, until the shares have been
transferred on the books of the Corporation in accordance with the  requirements
of these Bylaws.

         It shall be the duty of each  stockholder to notify the  Corporation of
his or her post office address and any changes thereto.

         SECTION 4. Record Date. In order that the Corporation may determine the
stockholders  entitled to notice of or to vote at any meeting of stockholders or
any adjournment  thereof or entitled to receive payment of any dividend or other
distribution  or allotment of any rights,  or entitled to exercise any rights in
respect of any change, conversion or exchange of stock or for the purpose of any
other lawful action,  the Board of Directors may fix a record date, which record
date shall not precede the date upon which the resolution fixing the record date
is adopted by the Board of Directors,  and which record date: (1) in the case of
determination  of stockholders  entitled to vote at any meeting of stockholders,
shall,  unless



                                       13




otherwise  required by law, not be more than sixty nor less than ten days before
the date of such meeting and (2) in the case of any other  action,  shall not be
more than sixty days prior to such other action. If no record date is fixed: (1)
the record date for determining stockholders entitled to notice of or to vote at
a meeting  of  stockholders  shall be at the close of  business  on the day next
preceding  the day on which  notice is given,  or, if notice is  waived,  at the
close of business on the day next preceding the day on which the meeting is held
and (2) the record date for determining stockholders for any other purpose shall
be at the close of  business on the day on which the Board of  Directors  adopts
the resolution relating thereto.

         SECTION 5.  Replacement of  Certificates.  In case of the alleged loss,
destruction or mutilation of a certificate of stock, a duplicate certificate may
be  issued in place  thereof,  upon such  terms as the  Board of  Directors  may
prescribe.



                                    ARTICLE V
                                    ---------
                            Miscellaneous Provisions
                            ------------------------


         SECTION 1. Fiscal Year. Except as otherwise  determined by the Board of
Directors,  the  fiscal  year of the  Corporation  shall  end on the last day of
November of each year.

         SECTION 2.  Seal. The Board of Directors  shall have power to adopt and
alter the seal of the Corporation.

         SECTION 3.  Execution of  Instruments.  All deeds,  leases,  transfers,
contracts,  bonds,  notes  and  other  obligations  to be  entered  into  by the
Corporation in the ordinary course of its business  without  Director action may
be executed on behalf of the Corporation by the Chairman of the Board, if one is
elected, the President or the Treasurer or any other officer,  employee or agent
of the  Corporation  as the  Board  of  Directors  or  Executive  Committee  may
authorize.

         SECTION  4.  Voting  of  Securities.  Unless  the  Board  of  Directors
otherwise provides,  the Chairman of the Board, if one is elected, the President
or the Treasurer may waive notice of and act on behalf of this  Corporation,  or
appoint  another  person or persons to act as proxy or attorney in fact for this
Corporation with or without discretionary power and/or power of substitution, at
any  meeting  of  stockholders  or  shareholders  of any  other  corporation  or
organization, any of whose securities are held by this Corporation.

         SECTION 5. Resident  Agent.  The  Board  of  Directors  may  appoint  a
resident agent upon whom legal process may be served in any action or proceeding
against the Corporation.

         SECTION 6 Corporate  Records.  The  original or attested  copies of the
Certificate  of  Incorporation,  Bylaws  and  records  of  all  meetings  of the
incorporators,  stockholders  and the Board of Directors and the stock  transfer
books, which shall contain the names of all



                                       14




stockholders,  their record  addresses and the amount of stock held by each, may
be kept outside the State of Delaware and shall be kept at the principal  office
of the Corporation, at the office of its counsel or at an office of its transfer
agent or at such other place or places as may be designated from time to time by
the Board of Directors.

         SECTION 7. Certificate of Incorporation. All references in these Bylaws
to the Certificate of Incorporation  shall be deemed to refer to the Certificate
of Incorporation of the Corporation, as amended and in effect from time to time.

         SECTION 8.  Amendment of Bylaws.

         (a) Amendment by Directors.  Except as provided otherwise by law, these
Bylaws may be amended or repealed by the  affirmative  vote of a majority of the
Directors then in office.

         (b) Amendment by Stockholders.  These Bylaws may be amended or repealed
at any annual meeting of stockholders, or special meeting of stockholders called
for such purpose,  by the affirmative  vote of at least  two-thirds of the total
votes  eligible  to be cast on such  amendment  or repeal by  holders  of voting
stock, voting together as a single class;  provided,  however, that if the Board
of Directors  recommends that  stockholders  approve such amendment or repeal at
such meeting of  stockholders,  such  amendment or repeal shall only require the
affirmative  vote of a majority of the total  votes  eligible to be cast on such
amendment  or repeal by holders of voting  stock,  voting  together  as a single
class.

  
                                       15


                                                                     EXHIBIT 4.2

                                                          Dated: August 16, 1996


                             STOCK PURCHASE WARRANT
                             ----------------------
                 Warrant to Purchase Shares of the Common Stock,
                             of PerArdua Corporation


         For value received,  PerArdua Corporation,  a Missouri corporation (the
"Company"),  hereby  grants to 900 Front  Street  Partners the right to purchase
(subject to the provisions of this Warrant) up to 13,396 shares of the Company's
Common Stock,  par value $0.001 per share (the "Stock"),  at a purchase price of
Ten Dollars ($10.00) per share (the "Exercise Price").

         The number of shares of Stock to be received  upon the exercise of this
Warrant  and  the  price  to be  paid  for a  share  of  Stock  may be  adjusted
periodically as hereinafter set forth. The shares of Stock deliverable upon such
exercise of this Warrant are hereinafter  sometimes  referred to as the "Warrant
Stock",  and the  purchase  price  per  share of Stock in  effect at any time is
hereinafter  sometimes  referred to as the "Exercise Price". The term "Warrant",
as  used  herein,  shall  include  this  Warrant  and  any  Warrants  issued  in
substitution  for or  replacement of this Warrant or into which this Warrant may
be divided or exchanged.

         (a)  Exercise of Warrant.

         On the terms and subject to the conditions herein set forth, the holder
shall have the right to exercise this Warrant in whole or in part at any time or
from time to time following the FDA Approval Date, as defined  hereafter,  until
5:00 p.m. Local Time on June 30, 2006, by presentation  and surrender  hereof to
the Company  together with the Purchase Form attached hereto duly executed,  and
accompanied by payment of the Exercise Price for the number of shares  specified
in such  Purchase  Form,  together  with all  federal and state  taxes,  if any,
applicable  upon such exercise.  The "FDA Approval Date" means the date on which
approval by the Food and Drug Administration is given permitting the public sale
of any products  developed from or in connection with the Assets,  as defined in
that  certain  Option and Asset  Purchase  Agreement  between  the  Company  and
PerArdua Investors, L.P., dated of even date herewith.

         If this Warrant  should be exercised in part only,  the Company  shall,
upon  surrender  of this  Warrant  for  cancellation,  execute and deliver a new
Warrant evidencing the right of the Holder to purchase the balance of the shares
purchasable hereunder on the terms specified herein. Upon receipt by the Company
of this Warrant in proper form for  exercise and payment of the Exercise  Price,
the  Holder  shall be deemed to be the  holder of record of the  shares of Stock
issuable upon such  exercise,  notwithstanding  that the stock transfer books of
the Company shall then be closed or that  certificates  representing such shares
of Stock shall not then be actually delivered to the Holder.








         (2) Net Issue Exercise.  Notwithstanding  any provisions  herein to the
contrary,  if the fair market value of one share of Common Stock is greater than
the Exercise Price (at the date of  calculation as set forth below),  in lieu of
exercising  this Warrant for cash,  the holder may elect to receive shares equal
to the value (as determined below) of this Warrant (or the portion thereof being
canceled) by surrender  of this Warrant at the  principal  office of the Company
together with the properly endorsed Purchase Form and notice of such election in
which event the  Company  shall issue to the Holder a number of shares of Common
Stock computed using the following formula:

                                    Y (A - B)
                               X = -----------
                                        A


         Where X = the  number of  shares  of  Common  Stock to be issued to the
holder

                           Y = the number of shares of Common Stock  purchasable
                               under the  Warrant  or, if only a portion  of the
                               Warrant is being  exercised,  the  portion of the
                               Warrant  being  canceled  (at  the  date  of such
                               calculation)

                           A = the  fair  market  value  of  one  share  of  the
                               Company's  Common  Stock  (at  the  date  of such
                               calculation)

                           B = Exercise  Price (as  adjusted to the date of such
                               calculation)

For  purposes  of the above  calculation,  fair market  value (the "Fair  Market
Value") of one share of Common Stock shall be determined by the Company's  Board
of Directors in good faith; provided,  however, that where there exists a public
market for the  Company's  Common Stock at the time of such  exercise,  the fair
market  value per share shall be the average of the closing bid and asked prices
of the Common Stock quoted in the  Over-The-Counter  Market  Summary or the last
reported  sale  price of the Common  Stock or the  closing  price  quoted on the
Nasdaq  National  Market or on any exchange on which the Common Stock is listed,
whichever is applicable,  as published in the Western Edition of The Wall Street
Journal for the five (5) trading days prior to the date of determination of fair
market  value.  Notwithstanding  the  foregoing,  in the  event the  Warrant  is
exercised in connection with the Company's initial public offering of the Common
Stock,  the fair market value per share shall be the per share offering price to
the public of the Company's initial public offering.


         (b) Reservation of Shares.  The Company hereby agrees that at all times
there shall be reserved for issuance and delivery  upon exercise of this Warrant
such number of shares of its Stock as shall be required for issuance or delivery
upon exercise.


                                       2



         (c) Fractional  Shares.  No fractional  shares shall be issued upon the
exercise of this  Warrant.  With  respect to any  fraction of a share called for
upon any exercise hereof,  the Company shall pay to the Holder an amount in cash
equal to such fraction multiplied by the current Fair Market Value of a share of
Stock.

         (d)  Exchange,   Loss  or  Mutilation  of  Warrant.   This  Warrant  is
exchangeable,  without expense,  at the option of the Holder,  upon presentation
and  surrender  hereof at the  office of the  Company,  for  other  Warrants  of
different  denominations  entitling  the Holder to purchase in the aggregate the
same  number of shares  of Stock  purchasable  hereunder.  Upon  receipt  by the
Company of evidence satisfactory to it of the loss, theft or destruction of this
Warrant, and of reasonably satisfactory indemnification,  and if mutilated, upon
surrender and cancellation of this Warrant, the Company will execute and deliver
a new Warrant with identical terms, conditions and date.

         (e) Rights of the Holder.  The Holder shall not, by virtue  hereof,  be
entitled  to any rights of a  shareholder  of the  Company,  either at law or in
equity,  and the  rights of the Holder are  limited  to those  expressed  in the
Warrant and are not  enforceable  against  the Company  except to the extent set
forth herein.

         (f) Restrictions on Transfer.

               (1) This Warrant shall not be  exercisable  and/or  transferrable
and the Warrant  Stock  shall not be  transferrable  except upon the  conditions
specified  in this Section  (f),  which  conditions  are  intended,  among other
things,  to insure  compliance with the provisions of the Securities Act of 1933
(the  "Securities  Act") in  respect of the  exercise  and/or  transfer  of such
Warrant and/or transfer of such Warrant Stock.

               (2) This Warrant shall not be  exercisable  and/or  transferrable
and the Warrant Stock shall not be transferrable  unless,  prior to any exercise
or transfer,  the Company  shall  receive from the holder of the Warrant or such
Warrant  Stock,  and/or the  transferee  thereof,  as the case may be, a written
notice  stating that such person is aware that Warrant  and/or the Warrant Stock
have not been  registered  under  the  Securities  Act and that  such  person is
acquiring the Warrant and/or Warrant Stock for investment  only and not with the
view to the disposition or public offering  thereof  (otherwise than an offering
registered  under the  Securities  Act) and that such  person is aware  that the
certificates  representing  the Warrant  Stock  shall bear a legend  restricting
re-transfer  and  disposition  thereof in  accordance  with the  Securities  Act
unless,  in the opinion of counsel to the  Company,  such legend may be omitted.
This Warrant  shall not be  transferrable  unless it has been  registered  under
applicable  securities  laws or unless  there is, in the  reasonable  opinion of
counsel  to  the  Company,   an  available   exemption  from  such  registration
requirement.



                                       3



         (g) Registration under Securities Act.

               (1) For a period beginning June 30, 1997 and ending June 30, 2006
(the "Piggyback Rights Period"),  if the Company proposes to file a registration
statement  (the  "Registration  Statement")  for  registration  of any shares of
Common Stock under the Securities Act other than a registration  relating solely
to an employee benefits plan or a corporate  reorganization or other transaction
under  Rule 145 or a  registration  on any form that does not  permit  secondary
sales, the Company will:

                    (i) Give written notice of such intention to the holder of a
         Warrant or Warrant  Stock (a "Holder",  and together with other holders
         of  Warrants  and  Warrant  Stock  dated  of even  date  herewith,  the
         "Holders") at least thirty (30) days prior to the proposed filing date;
         and

                    (ii) Use its best  efforts to  include in such  registration
         the number of shares of the Holder's  Warrant  Stock (the  "Registrable
         Securities")  specified  in a notice  received  by the  Company  within
         twenty  (20) days of the date of the notice  specified  in (i) above is
         mailed or delivered to the Holder.

Notwithstanding the foregoing, if in any firmly underwritten public offering the
managing  underwriter thereof determines that any of the Registrable  Securities
of the Holders  and any other  holders of  registration  rights must be excluded
from the  registration  as a result of marketing  factors,  which  determination
shall be given in writing, the number of shares of Registrable  Securities owned
by the Holders to be  included  in the  offering  shall be  allocated  among the
Holders and any other holders of registration rights pro rata in accordance with
the  number  of  shares  of  Common  Stock  requested  to be  included  in  such
registration.

               (2) If and whenever the Company is required by the  provisions of
this Section to use its best efforts to include any  Registrable  Securities  in
any  registration of any of its securities under the Securities Act, the Company
will, as expeditiously as possible and at its sole cost and expense:

                    (i) cause any  registration  statement  filed to become  and
         remain effective until all of the Registrable  Securities are sold, but
         not for any period longer than nine months;

                    (ii) prepare and file with the  Commission  such  amendments
         and supplements to such registration  statement and the prospectus used
         in connection  therewith as may be necessary to keep such  registration
         statement effective and to comply with the provisions of the Securities
         Act with respect to the  disposition of all securities  covered by such
         registration  statement whenever the Holders shall desire to dispose of
         the same;



                                       4



                    (iii)  furnish  to each  Holder  such  number of copies of a
         summary  prospectus  or  other  prospectus,   including  a  preliminary
         prospectus,  in conformity with the  requirements of the Securities Act
         and such other documents as such Holder may reasonably request in order
         to facilitate the  disposition of the securities  owned by such Holder;
         and

                    (iv)  use its  best  efforts  to  register  or  qualify  the
         securities  covered  by such  registration  statement  under such other
         securities or blue sky laws of such  jurisdictions as each Holder shall
         request  and use its  best  efforts  to do any and all  other  acts and
         things  which may be  reasonably  necessary  to enable  such  Holder to
         consummate the disposition in such jurisdiction of the securities owned
         by such Holder.

                    (v)  cause  all  such  Registrable   Securities   registered
         pursuant  hereunder to be listed on each  securities  exchange on which
         similar securities issued by the Company are then listed.

                    (vi)  provide  a  transfer   agent  and  registrar  for  all
         Registrable   Securities   registered  pursuant  to  such  registration
         statement and a CUSIP number for all such  Registrable  Securities,  in
         each case not later than the effective date of such registration.

               (3)  The  Company  shall  pay  all  expenses  incurred  by  it in
complying with this Section (g) (including  without  limitation all registration
and filing fees, printing expenses and fees and disbursements of counsel for the
Company) but not the fees and disbursements of counsel for the Holders.

               (4)  In the  event of any  registration of any of its  securities
under the  Securities  Act pursuant to this Section,  the Company will indemnify
and hold harmless the Holder of such  securities and each other person,  if any,
who controls such Holder within the meaning of the Securities Act and each other
person  who  participates  in the  offering  of  such  securities,  against  any
expenses,  losses,  claims,  damages or liabilities,  joint or several, to which
such Holder or  controlling  person or  participating  person may become subject
under the  Securities  Act or  otherwise,  in so far as such  expenses,  losses,
claims,  damages or liabilities  (or action in respect  thereof) arise out of or
are based upon any untrue  statement or alleged untrue statement of any material
fact  contained,  on  the  effective  date  thereof,  in  any  qualification  or
registration  statement under which such  securities  were registered  under the
Securities  Act or qualified  under any  applicable  state  securities  law, any
preliminary prospectus or final prospectus contained therein or any amendment or
supplement  thereto,  or any  document  incident  to any  such  registration  or
qualification  (collectively the "Offering  Documents"),  or arise out of or are
based upon the  omission or alleged  omission to state  therein a material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  or any violation of the Securities  Act or State  securities law or
any  other   regulation   thereunder  in  connection   with  any   registration,
qualification  or  compliance,  and will  reimburse  such  Holder  and each such
controlling  person or participating  person for any legal or any other expenses
reasonably  incurred by such Holder or such




                                       5




controlling  person or participating  person in connection with investigating or
defending any such loss, claim, damage, liability or action; provided,  however,
that the Company will not be liable in any such case to the extent that any such
expense,  loss,  claim,  damage or  liability  arises out of or is based upon an
untrue  statement or alleged  untrue  statement or omission or alleged  omission
made in any Offering  Document in reliance upon and in  conformity  with written
information furnished to the Company through an instrument duly executed by such
Holder specifically for use in the preparation thereof.  Each Holder shall, upon
the receipt of notice of the  commencement  of any action against such Holder or
against any such controlling person or participating person, in respect of which
indemnity may be sought from the Company on account of the  indemnity  agreement
contained in this Subsection  (g)(4),  promptly notify the Company in writing of
the commencement  thereof.  The omission of such Holder so to notify the Company
of any such action  shall not relieve the Company from any  liability  which the
Company  may have to such  Holder or such  controlling  person or  participating
person on account of the  indemnity  agreement  contained in this Section to the
extent such failure is not prejudicial. In case any such action shall be brought
against any Holder or any such controlling  person or  participating  person and
such Holder shall notify the Company of the  commencement  thereof,  the Company
shall be entitled to  participate  in (and, to the extent that the Company shall
wish,  to direct) the defense  thereof at the  Company's  own expense,  in which
event the defense shall be conducted by recognized counsel chosen by the Company
and reasonably  satisfactory to the Holder.  In the event of any registration by
the Company of any of its  securities  under the Securities Act pursuant to this
Section,  the Holder of the  securities  so registered  will  indemnify and hold
harmless  the Company and each other  person,  if any,  who controls the Company
within the meaning of the  Securities  Act and each  officer and director of the
Company and the other  Holders to the same  extent  that the  Company  agrees to
indemnify it, but only with respect to the written information  relating to such
Holder furnished to the Company by such Holder as aforesaid. Notwithstanding the
foregoing,  in no event  shall any  indemnity  by the  Holder  exceed  the gross
proceeds from the sale of Registrable  Securities received by such Holder in the
Offering.

         (h) Anti-Dilution Provisions.

               (1) In the event the  Company  shall (i) pay a dividend in shares
of  Stock,  or make a  distribution  in  shares of  Stock,  (ii)  subdivide  its
outstanding  shares of Stock, (iii) combine its outstanding shares of Stock into
a smaller  number of shares of Stock or (iv)  issue by  reclassification  of its
shares  of Stock  other  securities  of the  Company,  the  number  of shares of
purchasable  upon  exercise of this Warrant  immediately  prior thereto shall be
adjusted  so that the Holder of this  Warrant  shall be  entitled to receive the
kind and number of shares of Stock or other securities of the Company which such
Holder would have owned or have been  entitled to receive after the happening of
any such  event or any  record  date with  respect  thereto  if such  Holder had
exercised  such  Warrant  immediately  prior to such  event or record  date.  An
adjustment  made  pursuant to this  Subsection  (h)(1)  shall  become  effective
immediately  after the effective  date of such event  retroactive  to the record
date, if any, for such event.

               (2) Whenever the number of shares  purchasable  upon the exercise
of this  Warrant is adjusted as herein  provided,  the  Exercise  Price shall be
adjusted by multiplying such Exercise Price immediately prior to such adjustment
by a fraction,  of which the numerator shall be the number of shares purchasable
upon the exercise of each Warrant  immediately prior to such adjustment,  and of
which the denominator  shall be the number of shares so purchasable  immediately
thereafter.

               (3) No adjustment in the number of shares  purchasable  hereunder
shall be required unless such  adjustment  would require an increase or decrease
of at least  one (1%)  percent  in the  number of  shares  purchasable  upon the
exercise of this  Warrant;  provided,  however,  that any  adjustments  which by
reason of this  Subsection  (h)(3) are not  required to be made shall be carried
forward and taken into account in any subsequent adjustment.

               (4) For the purpose of this section,  the term "Stock" shall mean
(i) any class of stock designated as the Common Stock of the Company at the date
of this  Warrant,  or (ii) any other class of stock  resulting  from  successive
changes or  reclassifications of such shares consisting solely of changes in par
value,  or from par value to no par value, or from no par value to par value. In
the event that at any time, as a result of an  adjustment  made pursuant to this
section,  the Holders of a Warrant or Warrants shall become entitled to purchase
any shares of the Company other than shares of Stock,  thereafter  the number of
such other shares so purchasable  upon exercise of this Warrant and the Exercise
Price of such  shares  shall be  subject  to  adjustment  from time to time in a
manner and on terms as nearly  equivalent as practicable to the provisions  with
respect to the  Warrant  Stock  contained  in  Subsection  (h)(1)  through  (4),
inclusive, above.

               (5)  Merger,  Sale of  Assets,  Etc.  If at any time  while  this
Warrant, or any portion thereof, is outstanding and unexpired there shall be (i)
a  reorganization  (other  than a  combination,  reclassification,  exchange  or
subdivision  of  shares  otherwise  provided  for  herein),  (ii)  a  merger  or
consolidation  of the  Company  with or into  another  corporation  in which the
Company is not the surviving entity, or a reverse triangular merger in which the
Company is the surviving  entity but the shares of the  Company's  capital stock
outstanding  immediately  prior to the  merger  are  converted  by virtue of the
merger  into  other  property,  whether  in the  form of  securities,  cash,  or
otherwise,  or (iii) a sale or transfer of the Company's  properties  and assets
as, or substantially as, an entity to any other person,  then, as a part of such
reorganization,  merger, consolidation, sale or transfer, lawful provision shall
be made so that the holder of this  Warrant  shall  thereafter  be  entitled  to
receive upon exercise of this Warrant,  during the period  specified  herein and
upon payment of the Exercise Price then in effect, the number of shares of stock
or other securities or property of the successor corporation resulting from such
reorganization,  merger,  consolidation,  sale or transfer  that a holder of the
shares  deliverable  upon  exercise of this Warrant  would have been entitled to
receive in such reorganization,  consolidation, merger, sale or transfer if this
Warrant  had been  exercised  immediately  before such  reorganization,  merger,
consolidation,  merger,  sale or transfer,  all subject to further adjustment as
provided in this Section (h). The foregoing  provisions  of this Section  (h)(7)
shall similarly apply to successive  reorganizations,  consolidations,  mergers,
sales and




                                       7



transfers and to the stock or securities  of any other  corporation  that are at
the  time  receivable  upon  the  exercise  of this  Warrant.  If the  per-share
consideration  payable to the holder  hereof for shares in  connection  with any
such transaction is in a form other than cash or marketable securities, then the
value of such  consideration  shall be determined in good faith by the Company's
Board of Directors. In all events, appropriate adjustment (as determined in good
faith by the Company's  Board of Directors)  shall be made in the application of
the  provisions  of this Warrant with respect to the rights and interests of the
Holder after the  transaction,  to the end that the  provisions  of this Warrant
shall be applicable  after that event, as near as reasonably may be, in relation
to any shares or other  property  deliverable  after that event upon exercise of
this Warrant.

         (i) Officer's  Certificate.  Whenever the number of shares  purchasable
upon  exercise  of this  Warrant or the  Exercise  Price  shall be  adjusted  as
required by the  provisions of Section (h) hereof,  the Company shall  forthwith
cause a certificate  executed by its Chief Financial  Officer showing the number
of shares  purchasable  upon the exercise of this Warrant and the Exercise Price
after such  adjustment,  determined  as herein  provided,  and setting  forth in
reasonable detail the facts requiring such adjustment to be mailed to the Holder
of this Warrant.

         (j)  Notices  to  Warrant  Holders.  So long as this  Warrant  shall be
outstanding  and  unexercised  (i) if the Company shall pay any dividend or make
any  distribution  upon the  Stock  or (ii) if the  Company  shall  offer to the
holders of Stock for subscription or purchase by them any shares of Stock of any
class or any other rights or (iii) if any capital reorganization of the company,
reclassification of the capital stock of the Company, consolidation or merger of
the Company with or into another corporation,  sale, lease or transfer of all or
substantially  all  of  the  property  and  assets  of the  Company  to  another
corporation, or voluntary or involuntary dissolution,  liquidation or winding up
of the Company  shall be effected,  then,  in any such case,  the Company  shall
cause to be delivered to the Holder,  at least twenty-one (21) days prior to the
date  specified in (A) or (B) below,  as the case may be, a notice  containing a
brief  description  of the  proposed  action and stating the date on which (A) a
record is to be taken for purpose of such dividend,  distribution or rights,  or
(B) such reclassification,  reorganization,  consolidation,  merger, conveyance,
lease, dissolution,  liquidation or winding up is to take place and the date, if
any,  as of which the  holders of Stock of record  shall be entitled to exchange
their shares of Stock for  securities or other  property  deliverable  upon such
reclassification,    reorganization,    consolidation,    merger,    conveyance,
dissolution, liquidation or winding up.

         (k) Applicable Law. This Warrant shall be governed by, and construed in
accordance with, the laws of the State of Missouri.

         IN WITNESS  WHEREOF,  this Agreement has been duly executed by the duly
authorized officer of the Company as of the date first written above.



                                        8




                                                   PERARDUA CORPORATION


                                                By:
                                                   -----------------------------
                                                   Name:
                                                        ------------------------
                                                   Title:
                                                         -----------------------



ATTEST:


- ---------------------------
Samuel P. Sears, Jr., Secretary




                                       9



 
                                  PURCHASE FORM

                                                     DATED:______________, 19___

         The  undersigned  hereby  irrevocably  elects to  exercise  the  within
Warrant to the extent of purchasing  _______________  shares of Common Stock and
hereby makes payment of $_______________ in payment of the actual exercise price
thereof,  and requests that a certificate  for such shares be issued in the name
of the  undersigned  and be delivered to the  undersigned  at the address stated
below, and, if such number of shares shall not be all of the shares  purchasable
hereunder,  that a new  Warrant of like tenor for the  balance of the  remaining
shares  purchasable  hereunder be delivered  to the  undersigned  at the address
stated below:


                                            Signed:
                                                   -----------------------------
                                            Address:
                                                    ----------------------------

                                                    ----------------------------

                                            Social Security
                                            or Federal Tax
                                            I.D. #     
                                                       -------------------------




                                       10


                                                                     EXHIBIT 4.3

                                                                       EXHIBIT D

                             SUBSCRIPTION AGREEMENT
                             ----------------------

               In Connection with the Private Placement Memorandum
                                       of
                              PERARDUA CORPORATION
                                 August 20, 1996


         THIS SUBSCRIPTION  AGREEMENT (the "Agreement"),  made this _____ day of
___________________,  1996  by and  between  PERARDUA  CORPORATION,  a  Missouri
corporation  (the  "Company"),  and  the  undersigned  individual,  corporation,
partnership,  trust or employee  benefit plan  executing  this  Agreement as the
investor (the "Investor"), provides as follows:

                              W I T N E S S E T H:

         WHEREAS,  the Company  wishes to sell to the  Investor and the Investor
wishes to purchase from the Company  shares of the Company's  Common Stock,  par
value  $0.001 per share (the  "Shares"),  at a price of $1.60 per Share with the
number of Shares  subscribed  for being  specified on the signature  page hereof
subject to a minimum purchase of 31,250 Shares unless waived by the Company.

         WHEREAS,  the Investor has been furnished with the Confidential Private
Placement  Memorandum  dated August 20, 1996 and  Addendum  No. 1 thereto  dated
September 18, 1996  (collectively  referred to hereinafter as the  "Memorandum")
which has been prepared by the Company in connection with its offering of Shares
(the  "Offering").  Unless  (i)  otherwise  defined  herein or (ii) the  context
otherwise  requires,  capitalized terms used herein shall have the same meanings
given them in the Memorandum.

         NOW, THEREFORE,  in consideration of the foregoing and the promises and
covenants contained in this Agreement, the Company and the Investor hereby agree
as follows:

         1. Sale of Shares.  In accordance with the terms and conditions of this
Agreement,  the Company hereby agrees to sell to the Investor,  and the Investor
hereby agrees to purchase from the Company,  on or before the Closing Date,  the
number of Shares indicated on the signature page hereof.

         2. Purchase Price and  Subscription  Check. The purchase price for each
share of Common Stock shall be $1.60. The Investor shall pay such purchase price
by check made payable to "PerArdua Corporation" and delivered with this executed
Agreement and a completed  Purchaser  Questionnaire.  The Company's  sale of the
Shares is  contingent  upon  receipt and  acceptance  of  subscriptions  for all
665,000 Shares offered in the Offering.  Pending  receipt and acceptance of such
subscriptions,  the Investor's check will be held uncashed. On the Closing Date,
the  Investor's  check  will be cashed and the funds  will be  disbursed  to the
Company if such  subscriptions  have been  received  and  accepted,  or promptly
returned to the Investor  without interest if such  subscriptions  have not been
received and accepted.






         3. Representations of Investor. The Investor represents and warrants to
the Company that:

               3.1 He, she or it is acquiring the Shares for his, her or its own
account for investment and not with a view to resale or distribution.

               3.2 He, she or it: (i) has been  furnished,  has carefully  read,
and has relied  solely  (except as  indicated in  subsection  (ii) below) on the
information  contained  in  the  Memorandum  (including  all  exhibits  and  all
amendments  thereto,  if any);  (ii)  has  been  given  the  opportunity  to ask
questions of, and receive  answers from,  the Company  concerning  the terms and
conditions  of the  Offering,  the Shares,  the Company and its  business and to
obtain such additional  information that was otherwise provided,  and he, she or
it has not been  furnished any other  literature  relating to the Offering,  the
Shares, the Company or its business.

               3.3 He,  she or it  recognizes  (i) that  purchase  of the Shares
involves a high degree of risk and has taken full  cognizance of and understands
such risks,  including  those set forth in the section  entitled  "Risk Factors"
included  in the  Memorandum,  and  (ii)  that the  Company  has  relied  on the
representations  of the  Investor  as set  forth  in this  Section  3 and in the
Purchaser  Questionnaire attached as Appendix A hereto and made a part hereof in
determining  materiality  for  purposes  of the  disclosure  obligations  of the
Company under federal and state securities laws.

               3.4  He,  she  or it  represents  that  (i)  he,  she or it is an
"accredited  investor" as such term is defined in Rule 501 under the  Securities
Act of  1933,  as  amended  (the  "1933  Act"),  (ii) he,  she or it  meets  the
suitability  standards set forth in the section  entitled "Who Should Invest and
How to Invest" in the Memorandum, (ii) he, she or it can bear the risk of losing
the  entire  investment  in the  Shares;  (iii) the  overall  commitment  of the
Investor  to  other  investments  which  are  not  readily   marketable  is  not
disproportionate  to his, her or its net worth and the  investment in the Shares
will not cause such overall  commitment to become excessive;  (iv) he, she or it
has adequate means of providing for current needs and personal contingencies and
has no need for liquidity in the investment in the Shares; and (v) he, she or it
has sufficient  knowledge and experience in financial and business  matters such
that he,  she or it is  capable,  either  alone,  or  together  with one or more
advisors  (which  advisors  advised  him,  her  or it  in  connection  with  the
investment in the Shares),  of  evaluating  the risks and merits of investing in
the Shares.

               3.5  All  information  that  he,  she or it has  provided  to the
Company  concerning  himself,  herself or itself and his,  her or its  financial
position is correct and complete as of the date  hereof,  and if there should be
any material change in such information  prior to the issuance to him, her or it
of the Shares, he, she or it will immediately notify the Company.

               3.6 He, she or it fully understands and agrees that he, she or it
must  bear the  economic  risk of his,  her or its  purchase  of  Shares  for an
indefinite period of time because, among other reasons, the Shares have not been
registered  under the of 1933 Act,  or the  securities  laws of any  state,  and
therefore,  cannot be sold,  pledged,  assigned or otherwise  disposed of unless
they  are  subsequently  registered  under  the 1933  Act and  applicable  state
securities laws or an exemption from such registration is available.  He, she or
it further understands and agrees that the Company will not



                                       2




honor any  attempt by him,  her or it to sell,  pledge,  transfer  or  otherwise
dispose of the Shares, in the absence of an effective registration statement for
the Shares under the 1933 Act and applicable state securities laws or an opinion
of counsel,  satisfactory  in form and substance to the Company and its counsel,
that an exemption is available therefrom.

               3.7 The  Investor  certifies  that he, she or it has answered the
questions contained in the Purchaser Questionnaire attached hereto as Appendix A
and made a part  hereof to the best of his,  her or its  knowledge  and that the
answers thereto are complete and accurate.  The Investor  understands and agrees
that, although such answers will be kept strictly confidential,  the Company may
present such Purchaser  Questionnaire  to such parties as it deems  advisable if
called upon to establish the availability  under the federal or state securities
laws of an exemption  from  registration.  The Investor  agrees to indemnify the
Company,  its agents,  officers,  directors  and  shareholders,  for any and all
losses (including attorneys' fees) incurred by it as a result of its reliance on
any answers contained therein.

               3.8 If the Investor is a corporation,  limited  liability company
or partnership, it is authorized to make the investment contemplated herein, and
the person signing this Subscription Agreement on behalf of such entity has been
duly authorized by such entity to do so.

               3.9 If the Investor is a resident of or is  otherwise  purchasing
Shares in the State of  Missouri,  he,  she or it agrees  that the Shares may be
disposed of only through a licensed  broker-dealer and acknowledges that it is a
felony to sell securities in violation of the Missouri Securities Act.

         4. Registration Rights.

               4.1 If the Company proposes to file a registration statement (the
"Registration  Statement") for  registration of any shares of Common Stock under
the 1933 Act other than a registration  relating solely to an employee  benefits
plan or a  corporate  reorganization  or other  transaction  under Rule 145 or a
registration on any form that does not permit secondary sales, the Company will:

                    (i) Give  written  notice of such  intention to the Investor
(who,  together with other purchasers of Shares pursuant to the Offering,  shall
be referred to as the "Holders") at least thirty (30) days prior to the proposed
filing date; and

                    (ii) Use its best  efforts to  include in such  registration
the  number of shares of the  Investor's  Common  Stock  which  were  originally
purchased hereby (the "Registrable  Securities")  specified in a notice received
by the Company  within  twenty (20) days of the date of the notice  specified in
(i) above is mailed or delivered to the Investor.

Notwithstanding the foregoing, if in any firmly underwritten public offering the
managing  underwriter thereof determines that any of the Registrable  Securities
of the Holders  and any other  holders of  registration  rights must be excluded
from the  registration  as a result of marketing  factors,  which  determination
shall be given in writing, the number of shares of Registrable  Securities owned
by the Holders to be  included  in the  offering  shall be  allocated  among the
Holders and any other




                                       3



 holders of registration rights pro rata in accordance with
the  number  of  shares  of  Common  Stock  requested  to be  included  in  such
registration.

               4.2 If and whenever the Company is required by the  provisions of
this Section to use its best efforts to include any  Registrable  Securities  in
any  registration of any of its securities under the 1933 Act, the Company will,
as expeditiously as possible and at its sole cost and expense:

                    (i) cause any  registration  statement  filed to become  and
remain  effective until all of the Registrable  Securities are sold, but not for
any period longer than nine months;

                    (ii)  prepare  and file  with the  Securities  and  Exchange
Commission such amendments and  supplements to such  registration  statement and
the  prospectus  used in  connection  therewith as may be necessary to keep such
registration  statement  effective and to comply with the provisions of the 1933
Act  with  respect  to  the  disposition  of  all  securities  covered  by  such
registration statement whenever the Holders shall desire to dispose of the same;

                    (iii)  furnish  to each  Holder  such  number of copies of a
summary prospectus or other prospectus,  including a preliminary prospectus,  in
conformity  with the  requirements  of the 1933 Act and such other  documents as
such Holder may reasonably request in order to facilitate the disposition of the
securities owned by such Holder; and

                    (iv)  use its  best  efforts  to  register  or  qualify  the
securities covered by such registration statement under such other securities or
blue sky laws of such  jurisdictions  as each Holder  shall  request and use its
best  efforts to do any and all other acts and  things  which may be  reasonably
necessary  to  enable  such  Holder  to  consummate  the   disposition  in  such
jurisdiction of the securities owned by such Holder.

                    (v)  cause  all  such  Registrable   Securities   registered
pursuant  hereunder to be listed on each  securities  exchange on which  similar
securities issued by the Company are then listed.

                    (vi)  provide  a  transfer   agent  and  registrar  for  all
Registrable  Securities registered pursuant to such registration statement and a
CUSIP number for all such  Registrable  Securities,  in each case not later than
the effective date of such registration.

               4.3  The  Company  shall  pay  all  expenses  incurred  by  it in
complying with this Section 4 (including without limitation all registration and
filing fees,  printing  expenses and fees and  disbursements  of counsel for the
Company) but not the fees and disbursements of counsel for the Holders.

               4.4 In the  event of any  registration  of any of its  securities
under the 1933 Act pursuant to this Section, the Company will indemnify and hold
harmless  the Holder of such  securities  and each  other  person,  if any,  who
controls  such Holder  within the meaning of the 1933 Act and each other  person
who  participates  in the  offering of such  securities,  against any  expenses,
losses, claims,  damages or liabilities,  joint or several, to which such Holder
or controlling person or participating  person may become subject under the 1933
Act or  otherwise,  in so far as  such



                                        4




expenses,  losses, claims, damages or liabilities (or action in respect thereof)
arise out of or are based upon any untrue  statement or alleged untrue statement
of  any  material  fact  contained,  on  the  effective  date  thereof,  in  any
qualification  or  registration  statement  under  which  such  securities  were
registered under the 1933 Act or qualified under any applicable state securities
law, any preliminary  prospectus or final  prospectus  contained  therein or any
amendment  or  supplement   thereto,  or  any  document  incident  to  any  such
registration or qualification  (collectively the "Offering Documents"), or arise
out of or are based upon the  omission or alleged  omission  to state  therein a
material fact required to be stated  therein or necessary to make the statements
therein not misleading, or any violation of the 1933 Act or state securities law
or  any  other  regulation  thereunder  in  connection  with  any  registration,
qualification  or  compliance,  and will  reimburse  such  Holder  and each such
controlling  person or participating  person for any legal or any other expenses
reasonably  incurred by such Holder or such controlling  person or participating
person in  connection  with  investigating  or defending  any such loss,  claim,
damage,  liability or action;  provided,  however,  that the Company will not be
liable in any such case to the extent that any such expense, loss, claim, damage
or  liability  arises  out of or is based  upon an untrue  statement  or alleged
untrue statement or omission or alleged  omission made in any Offering  Document
in reliance upon and in  conformity  with written  information  furnished to the
Company through an instrument duly executed by such Holder  specifically for use
in the preparation thereof. Each Holder shall, upon the receipt of notice of the
commencement  of any action against such Holder or against any such  controlling
person or participating person, in respect of which indemnity may be sought from
the Company on account of the indemnity  agreement  contained in this Section 4,
promptly notify the Company in writing of the commencement thereof. The omission
of such Holder so to notify the Company of any such action shall not relieve the
Company  from any  liability  which the  Company may have to such Holder or such
controlling person or participating person on account of the indemnity agreement
contained in this Section to the extent such failure is not prejudicial. In case
any such  action  shall be brought  against  any Holder or any such  controlling
person or  participating  person and such Holder shall notify the Company of the
commencement  thereof,  the Company shall be entitled to participate in (and, to
the extent that the Company  shall wish,  to direct) the defense  thereof at the
Company's  own  expense,  in which  event  the  defense  shall be  conducted  by
recognized  counsel  chosen by the Company and  reasonably  satisfactory  to the
Holder. In the event of any registration by the Company of any of its securities
under the 1933 Act pursuant to this  Section,  the Holder of the  securities  so
registered  will  indemnify and hold harmless the Company and each other person,
if any,  who  controls  the Company  within the meaning of the 1933 Act and each
officer and  director  of the  Company and the other  Holders to the same extent
that the Company  agrees to  indemnify  it, but only with respect to the written
information  relating to such Holder  furnished to the Company by such Holder as
aforesaid. Notwithstanding the foregoing, in no event shall any indemnity by the
Holder  exceed  the  gross  proceeds  from  the sale of  Registrable  Securities
received by such Holder in the Offering.

         5. Legend.  The Investor  agrees that his, her or its  certificates  or
other  evidences of or for any and all of the Shares will be legended to reflect
the restrictions set forth in this Agreement.

         6. Applicable Law: This Agreement shall be construed in accordance with
and governed by the laws of the  Commonwealth of Virginia  without  reference to
the choice of law principles thereof.



                                        5




         7. Binding Effect:  Except as otherwise provided herein, this Agreement
shall be  binding  upon and  inure  to the  benefit  of the  parties  and  their
respective heirs, executors,  administrators,  successors, legal representatives
and assigns.

         8. Notice. All notices and other  communications  required or permitted
hereunder or necessary or convenient in connection  herewith shall be in writing
and shall be deemed to have been given when mailed by  registered  or  certified
mail or the next business day if sent by special courier such as Federal Express
(except  that  notice of  change of  address  shall be  deemed  given  only when
received),  to the address  shown on the Company's  records,  in the case of the
Investor,  and of the Company's Registered Agent, in the case of the Company, or
to such other names or addresses as the Company or the Investor, as the case may
be, shall designate by notice to the other party in the manner specified in this
Section.

         9.  Severability.  If any  provision of this  Agreement or  application
thereof to anyone or under any  circumstances  is  adjudicated  to be invalid or
unenforceable in any jurisdiction, such invalidity or unenforceability shall not
affect any other  provisions or applications of this Agreement that can be given
effect without the invalid or  unenforceable  provision or application and shall
not invalidate or render unenforceable the invalid or unenforceable provision in
any other jurisdiction or under any other circumstance.

         10.  Entire   Agreement.   This   Agreement   and  the   certificate(s)
representing  Unit(s) purchased hereunder constitute the entire agreement by and
between the parties  pertaining to the subject  matter hereof and supersedes all
prior and contemporaneous understandings of the parties.




                                       6




         IN WITNESS  WHEREOF,  this Agreement has been duly executed by the duly
authorized  officer of the  Company  and the  undersigned  Investor  or its duly
authorized officer, as the case may be, as of the date first written above.

                                             PERARDUA CORPORATION


                                             Signature:
                                                       -------------------------
                                             Title:
                                                   -----------------------------
                                             Date:
                                                  ------------------------------
         [Individual Subscriber]

                                             Signature:
                                                       -------------------------
                                             
                                             -----------------------------------
                                             [print individual name]
                                             Date:
                                                  ------------------------------


         [Other Subscribers]                 -----------------------------------
                                             [business name]

                                             Signature:
                                                       -------------------------

                                             -----------------------------------
                                             [print name]

                                             Its:
                                                 -------------------------------
                                             [describe office or position held]
                                             Date:
                                                  ------------------------------

         Number of Shares                              X $1.60 = $
                                             ---------            ----------



                                       7


                                                                     EXHIBIT 4.5


    THIS WARRANT AND THE SECURITIES  ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE
NOT BEEN  REGISTERED  UNDER THE  SECURITIES ACT OF 1933 (THE "ACT") OR ANY STATE
SECURITIES  LAWS  AND  MAY  NOT  BE  OFFERED,  SOLD,  TRANSFERRED,   PLEDGED  OR
HYPOTHECATED IN THE ABSENCE OF ANY EFFECTIVE  REGISTRATION  STATEMENT AS TO SUCH
SECURITIES  FILED  UNDER  THE  ACT,  OR  AN  EXEMPTION  FROM  REGISTRATION,  AND
COMPLIANCE  WITH  APPLICABLE  STATE  SECURITIES  LAWS. THE ISSUER MAY REQUIRE AN
OPINION OF COUNSEL  SATISFACTORY TO THE ISSUER HEREOF THAT SUCH  REGISTRATION IS
NOT REQUIRED AND THAT SUCH LAWS ARE COMPLIED WITH.



VOID AFTER 3:30 P.M., EASTERN TIME, ON                        2002



                                REPRESENTATIVE'S
                               WARRANT TO PURCHASE
                      COMMON STOCK AND REDEEMABLE WARRANTS

                              PERARDUA CORPORATION


This is to Certify That, FOR VALUE  RECEIVED,  Schneider  Securities,  Inc. (the
"Holder") is entitled to purchase,  subject to the  provisions  of this Warrant,
from PerArdua Corporation . ("Company"), a Delaware corporation,  at any time on
or after 1998,  and not later than 3:30 p.m.,  Eastern  Time, on , 2002 ,100,000
shares  of  Common  Stock  and  100,000  Redeemable   Warrants  of  the  Company
("Securities")  exercisable at a purchase price for the Securities which is 160%
of the public  offering price ,in the case of the 100,000 shares of Common Stock
at $ per  share  and in the case of the  100,000  Redeemable  Warrants  at $ per
Redeemable Warrant .The number of Securities to be received upon the exercise of
this Warrant and the price to be paid for the  Securities  may be adjusted  from
time to time as  hereinafter  set forth.  The  purchase  price of a Security  in
effect at any time and as adjusted  from time to time is  hereinafter  sometimes
referred to as the  "Exercise  Price." This Warrant is or may be one of a series
of Warrants  identical in form issued by the Company to purchase an aggregate of
100,000  Shares  of  Common  Stock  and  100,000  Redeemable   Warrants  ..  The
Securities,  as  adjusted  from  time  to  time,  underlying  the  Warrants  are
hereinafter  sometimes  referred  to as  "Warrant  Securities".  The  Securities
issuable  upon  the  exercise  hereof  are  in  all  respects  identical  to the
securities  being purchased by the Underwriter for resale to the public pursuant
to the terms and conditions of the Underwriting  Agreement  entered into on this
date between the Company and Holder, except that the Exercise Price per share of
Common  Stock  to be  acquired  upon the  exercise  of the  Redeemable  Warrants
issuable to Holder pursuant hereto shall be $ per share.

(a)   Exercise of Warrant. Subject to the provisions of Section (g) hereof, this
Warrant may be  exercised in whole or in part at anytime or from time to time on
or after , 1998,  but not later than 3:30 p.m.,  Eastern Time on , 2002, or if ,
2002 is a day on which banking institutions are authorized by law to close, then
on the next  succeeding day which shall not be such a day, by  presentation  and
surrender hereof to the Company or at the office of its stock transfer agent, if
any, with the Purchase  Form annexed  hereto duly  executed and  accompanied  by
payment  of the  Exercise  Price for the  number  of  shares of Common  Stock or
Redeemable Warrants, as the case may be as speficied in such Form, together with
all federal and state taxes applicable upon such exercise. The Company agrees to
provide  notice  to the  Holder  that any  tender  offer  is being  made for the
Securities no later than the day the Company becomes aware that any tender offer
is being made for the  Securities.  If this Warrant  should be exercised in part
only,  the Company  shall,  upon  surrender  of this  Warrant for  cancellation,
execute and deliver a new Warrant evidencing the right of the Holder to purchase
the  balance  of the shares  purchasable  hereunder  along  with any  additional
Redeemable  Warrants not exercised.  Upon receipt by the Company of this Warrant
at the office of the Company or at the office of









the Company's  stock transfer agent, in proper form for exercise and accompanied
by the total  Exercise  Price,  the  Holder  shall be deemed to be the holder of
record of the Securities issuable upon such exercise,  notwithstanding  that the
stock  transfer  books of the Company shall then be closed or that  certificates
representing such Securities shall not then be actually delivered to the Holder.


    (b)  Reservation of Securities.  The Company hereby agrees that at all times
there shall be reserved  for  issuance  and/or  delivery  upon  exercise of this
Warrant such number of shares of Securities as shall be required for issuance or
delivery upon exercise of this Warrant.  The Company  covenants and agrees that,
upon exercise of the Warrants and payment of the Exercise  Price  therefor,  all
Securities  and other  securities  issuable upon such exercise shall be duly and
validly  issued,  fully paid,  non-assessable  and not subject to the preemptive
rights of any  stockholder.  As long as the Warrants shall be  outstanding,  the
Company  shall use its best efforts to cause all  Securities  issuable  upon the
exercise of the Warrants to be listed  (subject to official  notice of issuance)
on all  securities  exchanges  on which the Common Stock issued to the public in
connection herewith may then be listed and/or quoted on NASDAQ.

    (c) Fractional Shares. No fractional shares or scrip representing fractional
shares  shall be issued upon the exercise of this  Warrant.  With respect to any
fraction of a share called for upon any exercise  hereof,  the Company shall pay
to the Holder an amount in cash equal to such fraction multiplied by the current
market value of such fractional share, determined as follows:

       (1) If the  Securities  are listed on a national  securities  exchange or
admitted to unlisted  trading  privileges  on such  exchange,  the current value
shall be the last  reported  sale price of the Common Stock on such  exchange on
the last  business  day prior to the date of exercise  of this  Warrant or if no
such sale is made on such day,  the average of the closing bid and asked  prices
for such day on such exchange; or

    (2) If the  Securities  are not so listed or admitted  to  unlisted  trading
privileges,  the current  value shall be the mean of the last  reported  bid and
asked  prices  reported  by  the  National  Association  of  Securities  Dealers
Automated  Quotation  System (or, if not so quoted on NASDAQ or by the  National
Quotation  Bureau,  Inc.)  on the  last  business  day  prior to the date of the
exercise of this Warrant; or

    (3) If the  Securities  are not so listed or admitted  to  unlisted  trading
privileges and bid and asked prices are not so reported, the current value shall
be an amount, not less than book value,  determined in such reasonable manner as
may be prescribed by the Board of Directors of the Company,  such  determination
to be final and binding on the Holder.

    (d) Exchange,  Assignment or Loss of Warrant.  This Warrant is exchangeable,
without expense,  at the option of the Holder,  upon  presentation and surrender
hereof to the Company or at the office of its stock transfer  agent, if any, for
other  Warrants  of  different  denominations  entitling  the Holder  thereof to
purchase  (under the same terms and  conditions  as provided by this Warrant) in
the aggregate the same number of Securities purchasable hereunder.  This Warrant
may not be sold,  transferred,  assigned,  or hypothecated  until after one year
from the effective date of the registration  statement except that it may be (i)
assigned  in  whole  or in part to the  officers  of the  "Underwriter(s)",  and
(ii)transferred  to any successor to the business of the  "Underwriter(s)."  Any
such assignment shall be made by surrender of this Warrant to the Company, or at
the office of its stock transfer agent, if any, with the Assignment Form annexed
hereto  duly  executed  and  with  funds  sufficient  to pay any  transfer  tax;
whereupon the Company shall,  without charge,  execute and deliver a new Warrant
in the name of the assignee  named in-such  instrument of  assignment,  and this
Warrant shall promptly be canceled. This Warrant may be divided or combined with
other  Warrants  which  carry the same rights  upon  presentation  hereof at the
office of the  Company or at the  office of its stock  transfer  agent,  if any,
together with a written notice  specifying the names and  denominations in which
new  Warrants  are to be  issued  and  signed  by the  Holder  hereof.  The term
"Warrant" as used herein  includes any Warrants  issued in  substitution  for or
replacement  of this  Warrant,  or into  which  this  Warrant  may be divided or
exchanged.  Upon  receipt by the Company of evidence  satisfactory  to it of the
loss,  theft,  destruction  or mutilation  of this Warrant,  and (in the case of
loss, theft or destruction) of reasonably satisfactory indemnification, and upon
surrender  and  cancellation  of this Warrant,  if  mutilated,  the Company will
execute and  deliver a new Warrant of like tenor and date.



                                       2


Any such new Warrant  executed and  delivered  shall  constitute  an  additional
contractual obligation on the part of the Company, whether or not the Warrant so
lost,  stolen,  destroyed,  or  mutilated  shall be at any time  enforceable  by
anyone.

    (e)  Rights of the  Holder.  The  Holder  shall not,  by virtue  hereof,  be
entitled to any rights of a stockholder in the Company, either at law or equity,
and the rights of the Holder are limited to those  expressed  in the Warrant and
are not enforceable against the Company except to the extent set forth herein.

    (f) Notices to Warrant Holders. So long as this Warrant shall be outstanding
and  unexercised  (i) if the Company shall pay any dividend  exclusive of a cash
dividend, or make any distribution upon the Common Stock, or (ii) if the Company
shall offer to the holders of Common Stock for  subscription or purchase by them
any shares of stock of any class or any other  rights,  or (iii) if any  capital
reorganization  of the  Company,  reclassification  of the capital  stock of the
Company,   consolidation   or  merger  of  the  Company  with  or  into  another
corporation, sale, lease or transfer of all or substantially all of the property
and assets of the Company to another  corporation,  or voluntary or  involuntary
dissolution,  liquidation or winding up of the Company shall be effected,  then,
in any such case,  the Company  shall cause to be  delivered  to the Holder,  at
least ten (10) days prior to the date specified in (x) or (y) below, as the case
may be, a notice  containing  a brief  description  of the  proposed  action and
stating  the date on which (x) a record is to be taken for the  purpose  of such
dividend, distribution or rights, or (y) such reclassification,  reorganization,
consolidation, merger, conveyance, lease, dissolution, liquidation or winding up
is to take place and the date,  if any, is to be fixed,  as of which the holders
of Common Stock of record  shall be entitled to exchange  their shares of Common
Stock  for  equivalent  securities  or  other  property  deliverable  upon  such
reclassification,    reorganization,    consolidation,    merger,    conveyance,
dissolution, liquidation or winding up.

      (g)  Adjustment  of  Exercise  Price and Number of Shares of Common  Stock
Deliverable.

    (A)(i) Except as hereinafter  provided,  in the event the Company shall,  at
any time or from time to time after the date hereof,  issue any shares of Common
Stock as a stock  dividend  to the  holders of Common  Stock,  or  subdivide  or
combine the  outstanding  shares of Common Stock into a greater or lesser number
of shares (any such issuance,  subdivision  or  combination  being herein call a
"Change of Shares"),  then, and  thereafter  upon each further Change of Shares,
the Exercise Price of the Common Stock issuable upon the exercise of the Warrant
and the Redeemable  Warrant in effect immediately prior to such Change of Shares
shall be changed to a price (including any applicable  fraction of a cent to the
nearest  cent)  determined  by dividing  (i) the sum of (a) the total  number of
shares of Common Stock  outstanding  immediately prior to such Change of Shares,
multiplied by the Exercise Price in effect  immediately  prior to such Change of
Shares,  and (b) the  consideration,  if any,  received by the Company upon such
issuance,  subdivision  or  combination  by (ii) the  total  number of shares of
Common  Stock  outstanding  immediately  after such Change of Shares;  provided,
however,  that in no event shall the Exercise Price be adjusted pursuant to this
computation to an amount in excess of the Exercise  Price in effect  immediately
prior to such  computation,  except in the case of a combination  of outstanding
shares of Common Stock.

    For the  purposes  of any  adjustment  to be made in  accordance  with  this
Section (g) the following provisions shall be applicable:

    (I) Shares of Common Stock issuable by way of dividend or other distribution
on any  capital  stock  of the  Company  shall be  deemed  to have  been  issued
immediately  after the opening of business on the day  following the record date
for the determination of shareholders entitled to receive such dividend or other
distribution and shall be deemed to have been issued without consideration.

    (II) The number of shares of Common Stock at any one time outstanding  shall
not be deemed to include the number of shares issuable  (subject to readjustment
upon the actual  issuance  thereof)  upon the  exercise  of  options,  rights or
warrants and upon the  conversion  or exchange of  convertible  or  exchangeable
securities.

    (ii) Upon each  adjustment  of the Exercise  Price  pursuant to this Section
(g), the number of shares of Common Stock and  Redeemable  Warrants  purchasable
upon the exercise of each Warrant shall be the number derived by multiplying the
number of shares of Common Stock and Redeemable Warrants purchasable immediately
prior  to



                                       3


such  adjustment by the Exercise  Price in effect prior to such  adjustment  and
dividing the product so obtained by the applicable adjusted Exercise Price.



    (B) In case of any  reclassification  or  change of  outstanding  Securities
issuable  upon  exercise of the Warrants  (other than a change in par value,  or
from par value to no par value, or from no par value to par value or as a result
of a subdivision or combination),  or in case of any  consolidation or merger of
the  Company  with  or into  another  corporation  other  than a  merger  with a
"Subsidiary" (which shall mean any corporation or corporations,  as the case may
be, of which  capital  stock  having  ordinary  power to elect a majority of the
Board of Directors of such corporation (regardless of whether or not at the time
capital  stock of any other class or classes of such  corporation  shall have or
may have voting power by reason of the happening of any  contingency)  is at the
time directly or indirectly owned by the Company or by one or more Subsidiaries)
or by the Company and one or more  Subsidiaries  in which  merger the Company is
the continuing  corporation and which does not result in any reclassification or
change of the then  outstanding  shares of Common Stock or other  capital  stock
issuable  upon  exercise of the Warrants  (other than a change in par value,  or
from par value to no par value, or from no par value to par value or as a result
of subdivision or  combination)  or in case of any sale or conveyance to another
corporation of the property of the Company as an entirety or substantially as an
entirety, then, as a condition of such reclassification,  change, consolidation,
merger,  sale or  conveyance,  the  Company,  or such  successor  or  purchasing
corporation,  as the case may be,  shall  make  lawful  and  adequate  provision
whereby  the  Holder  of each  Warrant  then  outstanding  shall  have the right
thereafter  to  receive  on  exercise  of such  Warrant  the kind and  amount of
securities  and  property   receivable  upon  such   reclassification,   change,
consolidation,  merger,  sale  or  conveyance  by a  holder  of  the  number  of
securities  issuable  upon  exercise of such Warrant  immediately  prior to such
reclassification,  change,  consolidation,  merger, sale or conveyance and shall
forthwith file at the principal  office of the Company a statement signed by its
President or a Vice President and by its Treasurer or an Assistant  Treasurer or
its  Secretary  or  an  Assistant  Secretary  evidencing  such  provision.  Such
provisions  shall  include  provision for  adjustments  which shall be as nearly
equivalent  as may be  practicable  to the  adjustments  provided for in Section
(g)(A).  The above  provisions of this Section (g)(B) shall  similarly  apply to
successive  reclassifications  and  changes  of shares  of  Common  Stock and to
successive consolidations, mergers, sales or conveyances.

    (C)  Irrespective of any adjustments or changes in the Exercise Price or the
number of Securities  purchasable  upon  exercise of the  Warrants,  the Warrant
Certificates  theretofore and thereafter issued shall,  unless the Company shall
exercise its option to issue new Warrant Certificates pursuant hereto,  continue
to express  the  Exercise  Price per share and the number of shares  purchasable
thereunder as the Exercise Price per share and the number of shares  purchasable
thereunder  as  expressed  in  the  Warrant  Certificates  when  the  same  were
originally issued.

    (D) After each  adjustment  of the Exercise  Price  pursuant to this Section
(g), the Company will promptly  prepare a certificate  signed by the Chairman or
President, and by the Treasurer or an Assistant Treasurer or the Secretary or an
Assistant Secretary,  of the Company setting forth: (i) the Exercise Price as so
adjusted,  (ii) the  number of  Securities  purchasable  upon  exercise  of each
Warrant,  after  such  adjustment,  and  (iii' a brief  statement  of the  facts
accounting for such adjustment.  The Company will promptly file such certificate
in the Company's  minute books and cause a brief  summary  thereof to be sent by
ordinary  first class mail to each Holder at his last address as it shall appear
on the  registry  books of the  Company.  No failure to mail such notice nor any
defect  therein or in the mailing  thereof  shall  affect the  validity  thereof
except as to the  holder to whom the  Company  failed  to mail such  notice,  or
except as to the holder whose notice was defective.  The affidavit of an officer
or the  Secretary or an Assistant  Secretary of the Company that such notice has
been mailed shall, in the absence of fraud, be prima facie evidence of the facts
stated therein.

    (E) No adjustment  of the Exercise  Price shall be made as a result of or in
connection  with  the  issuance  or sale of  Securities  if the  amount  of said
adjustment shall be less than $.10,  provided,  however,  that in such case, any
adjustment  that would  otherwise  be required  then to be made shall be carried
forward and shall be made at the time of and together  with the next  subsequent
adjustment that shall amount,  together with any adjustment so carried  forward,
to at least $.10. In addition,  Holders shall not be entitled to cash  dividends
paid by the Company  prior to the  exercise  of any Warrant or Warrants  held by
them.



                                       4


    (F) In the event that the Company shall at any time prior to the exercise of
all Warrants declare a dividend  consisting  solely of shares of Common Stock or
otherwise distribute to its stockholders any assets, property, rights, evidences
of  indebtedness,  the Holders of the unexercised  Warrants shall  thereafter be
entitled,  in  addition  to the  Securities  or other  securities  and  property
receivable  upon the  exercise  thereof,  to receive,  upon the exercise of such
Warrants,  the same property,  assets, rights,  evidences of indebtedness,  that
they  would  have been  entitled  to  receive  at the time of such  dividend  or
distribution  as if the Warrants had been  exercised  immediately  prior to such
dividend or distribution. At the time of any such dividend or distribution,  the
Company shall make appropriate  reserves to ensure the timely performance of the
provisions of this Section (g).

    (h) Piggyback  Registration.  If, at any time  commencing  one year from the
effective  date of the  registration  statement  and  expiring  four  (4)  years
thereafter,  the Company  proposes to register any of its  securities  under the
Securities Act of 1933, as amended (the "Act") (other than in connection  with a
merger or pursuant to Form S-8, S-4 or other comparable  registration statement)
it will give written notice by registered  mail, at least thirty (30) days prior
to the filing of each such  registration  statement,  to the  Holders and to all
other Holders of the Warrants and/or the Warrant  Securities of its intention to
do so. If the Holder or other Holders of the Warrants and/or Warrant  Securities
notify the Company  within  twenty (20) days after receipt of any such notice of
its or their desire to include any such securities in such proposed registration
statement,  the Company shall afford each of the Underwriter and such Holders of
the Warrants and/or Warrant  Securities the opportunity to have any such Warrant
Securities registered under such registration statement.

    Notwithstanding  the provisions of this Section,  the Company shall have the
right at any time after it shall  have given  written  notice  pursuant  to this
Section  (irrespective  of whether a written  request for  inclusion of any such
securities  shall  have  been  made)  to elect  not to file  any  such  proposed
registration  statement,  or to withdraw  the same after the filing but prior to
the effective date thereof.

      (i)    Demand Registration.

(1) At any time commencing one year from the effective date of the  registration
statement  and expiring four (4) years  thereafter,  the Holders of the Warrants
and/or Warrant Securities  representing a "Majority" (as hereinafter defined) of
such  securities  (assuming the exercise of all of the Warrants)  shall have the
right (which right is in addition to the  registration  rights under Section (i)
hereof),  exercisable  by written  notice to the  Company,  to have the  Company
prepare and file with the Securities and Exchange Commission (the "Commission"),
on one occasion, a registration statement and such other documents,  including a
prospectus,  as may be  necessary in the opinion of both counsel for the Company
and  counsel  for the  Underwriter  and  Holders,  in order to  comply  with the
provisions  of the Act,  so as to  permit a  public  offering  and sale of their
respective  Warrant  Securities for nine (9) consecutive  months by such Holders
and any other holders of the Warrants  and/or Warrant  Securities who notify the
Company  within ten (10) days after  receiving  notice  from the Company of such
request.

    (2)  The  Company  covenants  and  agrees  to  give  written  notice  of any
registration  request  under  this  Section  (i) by any Holder or Holders to all
other registered  Holders of the Warrants and the Warrant  Securities within ten
(10) days from the date of the receipt of any such registration request.

    (3) In addition to the  registration  rights  under this  Section (i) at any
time commencing one year after the effective date of the registration  statement
and expiring four (4) years thereafter, the Holders of Representative's Warrants
and/or Warrant  Securities shall have the right,  exercisable by written request
to the Company, to have the Company prepare and file, on one occasion,  with the
Commission a registration  statement so as to permit a public  offering and sale
for nine (9)  consecutive  months by such  Holders  of its  Warrant  Securities;
provided,  however, that the provisions of Section (i)(2) hereof shall not apply
to any such registration request and registration and all costs incident thereto
shall be at the expense of the Holder or Holders making such request.



                                       5


     (j)  Covenants of the Company With Respect to  Registration.  In connection
with any registration under Section (h) or (i) hereof, the Company covenants and
agrees as follows:

    (i) The Company shall use its best efforts to file a registration  statement
within  sixty (60) days of receipt  of any demand  therefor,  shall use its best
efforts to have any registration  statement  declared  effective at the earliest
possible time, and shall furnish each Holder desiring to sell Warrant Securities
such number of prospectuses as shall reasonably be requested.

    (ii) The  Company  shall  pay all  costs  (excluding  fees and  expenses  of
Holder(s)'  counsel  and any  underwriting  or  selling  commissions),  fees and
expenses  in  connection  with all  registration  statements  filed  pursuant to
Sections (h), (i) and (j) hereof including,  without  limitation,  the Company's
legal and accounting fees, printing expenses, blue sky fees and expenses. If the
Company shall fail to comply with the provisions of Section (j)(i),  the Company
shall,  in addition to any other  equitable  or other  relief  available  to the
Holder(s),  extend the Exercise Period by such number of days as shall equal the
delay caused by the Company's failure.

    (iii)The  Company  will take all  necessary  action which may be required in
qualifying or  registering  the Warrant  Securities  included in a  registration
statement  for offering and sale under the  securities  or blue sky laws of such
states as are reasonably  requested by the Holder(s),  provided that the Company
shall not be  obligated  to  execute or file any  general  consent to service of
process to qualify as a foreign corporation to do business under the laws of any
such jurisdiction.

    (iv) The Company shall indemnify the Holder(s) of the Warrant  Securities to
be sold  pursuant to any  registration  statement  and each person,  if any, who
controls  such  Holders  within the  meaning of Section 15 of the Act or Section
20(a) of the Securities  Exchange Act of 1934, as amended ("Exchange Act"), from
and  against  all loss,  claim,  damage,  expense or  liability  (including  all
expenses  reasonably  incurred in investigating,  preparing or defending against
any claim whatsoever) to which any of them may become subject under the Act, the
Exchange Act or otherwise,  arising from such registration statement but only to
the same extent and with the same effect as the provisions pursuant to which the
Company has agreed to indemnify  the  Underwriter  contained in Section 7 of the
Underwriting Agreement relating to the offering.

    (v)  The  Holder(s)  of the  Warrant  Securities  to be sold  pursuant  to a
registration statement,  and their successors and assigns, shall severally,  and
not jointly,  indemnify the Company, its officers and directors and each person,
if any, who controls the Company  within the meaning of Section 15 of the Act or
Section 20(a) of the Exchange Act, against all loss, claim, damage or expense or
liability   (including  all  expenses   reasonably  incurred  in  investigating,
preparing or defending  against any claim  whatsoever)  to which they may become
subject under the Act, the Exchange Act or otherwise,  arising from  information
furnished by or on behalf of such Holders,  or their successors or assigns,  for
specific  inclusion in such  registration  statement to the same extent with the
same  effect  as the  provisions  contained  in  Section  7 of the  Underwriting
Agreement pursuant to which the Underwriter has agreed to indemnify the Company.

         (vi) The Holder(s)  may exercise  their  Warrants  prior to the initial
filing of any registration statement or the effectiveness thereof.


    (vii)The Company shall not permit the inclusion of any securities other than
the  Warrant  Securities  to be  included in any  registration  statement  filed
pursuant to Section (i) hereof, or permit any other registration statement to be
or remain effective during the  effectiveness of a registration  statement filed
pursuant  to Section  (i)  hereof,  other than a  secondary  offering  of equity
securities of the Company,  without the prior written  consent of the Holders of
the Warrants and Warrant  Securities  representing a Majority of such securities
(assuming an exercise of all the Warrants underlying the Warrants).

(viii) The Company  shall furnish to each Holder  participating  in the offering
and to each underwriter, if any, a signed counterpart,  addressed to such Holder
or underwriter, of (x) an opinion of counsel to the Company, dated the


                                       6



effective  date of  such  registration  statement  (and,  if  such  registration
includes  an  underwritten  public  offering,  an opinion  dated the date of the
closing under the underwriting agreement), and (y) a "cold comfort" letter dated
the effective date of such  registration  statement  (and, if such  registration
includes an underwritten public offering, a letter dated the date of the closing
under the underwriting  agreement) signed by the independent  public accountants
who have issued a report on the Company's financial  statements included in such
registration  statement,  in each case covering  substantially  the same matters
with  respect  to such  registration  statement  (and  the  prospectus  included
therein) and, in the case of such  accountants'  letter,  with respect to events
subsequent to the date of such financial statements,  as are customarily covered
in  opinions  of  issuer's  counsel and in  accountants'  letters  delivered  to
underwriters in underwritten public offerings of securities.

    (ix) The Company shall as soon as  practicable  after the effective  date of
the registration statement,  and in any event within 15 months thereafter,  make
"generally  available to its security  holders"  (within the meaning of Rule 158
under the Act) an earnings  statement (which need not be audited) complying with
Section 11(a) of the Act and covering a period of at least 12 consecutive months
beginning after the effective date of the registration statement.

    (x) The Company shall deliver  promptly to each Holder  participating in the
offering  requesting the correspondence and memoranda described below and to the
managing  underwriters,  copies of all correspondence between the Commission and
the Company,  its counsel or auditors and all memoranda  relating to discussions
with the Commission or its staff with respect to the registration  statement and
permit each Holder and  underwriter to do such  investigation,  upon  reasonable
advance  notice,  with respect to  information  contained in or omitted from the
registration   statement  as  it  deems  reasonably  necessary  to  comply  with
applicable  securities  laws or rules of the National  Association of Securities
Dealers,  Inc. ("NASD") or an Exchange.  Such investigation shall include access
to books,  records and properties and  opportunities  to discuss the business of
the Company with its officers and independent  auditors,  all to such reasonable
extent  and at  such  reasonable  times  and as  often  as any  such  Holder  or
underwriter shall reasonably request.

    (xi)  The  Company  shall  enter  into an  underwriting  agreement  with the
managing  underwriters,  which may be the  Underwriter.  Such agreement shall be
satisfactory   in  form  and  substance  to  the  Company,   and  such  managing
underwriters,  and shall contain such representations,  warranties and covenants
by the Company and such other terms as are  customarily  contained in agreements
of that type used by the managing underwriter;  provided however, that no Holder
shall be required to make any representations,  warranties or covenants or grant
any indemnity to which it shall object in any such underwriting  agreement.  The
Holders  shall  be  parties  to  any  underwriting   agreement  relating  to  an
underwritten sale of their Warrant Securities and may, at their option,  require
that any or all the representations,  warranties and covenants of the Company to
or for  the  benefit  of  such  underwriters  shall  also be made to and for the
benefit  of such  Holders.  Such  Holders  shall  not be  required  to make  any
representations  or  warranties  to  or  agreements  with  the  Company  or  the
underwriters  except as they may  relate  to such  Holders  and  their  intended
methods of distribution.

    (xii)For  purposes of this  Agreement,  the term " Majority" in reference to
the  Holders of Warrants  or Warrant  Securities,  shall mean in excess of fifty
(50%) of the then outstanding  Warrants and Warrant  Securities that (i) are not
held by the Company, an affiliate,  officer, creditor, employee or agent thereof
or any of their respective  affiliates,  members of their family, persons acting
as  nominees  or in  conjunction  therewith  or (ii) have not been resold to the
public pursuant to a registration  statement filed with the Commission under the
Act.

(k) Conditions of Company's Obligations.  The Company's obligation under Section
j hereof shall be  conditioned  as to each such public  offering,  upon a timely
receipt by the Company in writing of:

      (A) Information as to the terms of such public offering furnished by or on
behalf of the Holders making a public  distribution of their Warrant Securities;
and

    (B) Such other  information as the Company may reasonably  require from such
Holder,  or any underwriter for any of them, for inclusion in such  registration
statement or offering statement or post-effective amendment.



                                       7


     (C) An agreement by the Holder to sell his Warrants and Warrant  Securities
on the basis provided in the Underwriting Agreement.

      (1) Continuing Effect of Agreement.  The Company's agreements with respect
to the Warrant  Securities in this Warrant will continue in effect regardless of
the exercise or surrender of this Warrant.

    (m) Notices. Any notices or certificates by the Company to the Holder and by
the Holder to the Company shall be deemed  delivered if in writing and delivered
personally or sent by certified  mail,  to the Holder,  addressed to him or sent
to, Schneider Securities, Inc. 1120 Lincoln Street, Denver, CO 80203, or, if the
Holder has designated,  by notice in writing to the Company,  any other address,
to such other address,  and, if to the Company,  addressed to Francis O'Donnell,
President,  PerArdua  Corporation,  709 The Hamptons Lane, Town and Country,  MO
63017.  The  Company  may change its  address  by  written  notice to  Schneider
Securities, Inc.

    (n) Limited  Transferability.  This Warrant  Certificate and the Warrant may
not be sold,  transferred,  assigned or hypothecated for a one-year period after
the effective date of the  Registration  Statement except to underwriters of the
Offering  referred to in the  Underwriting  Agreement or to individuals  who are
either partners or officers of such an underwriter or by will or by operation of
law. The Warrant may be divided or combined,  upon request to the Company by the
Warrantholder,  into a certificate or certificates evidencing the same aggregate
number of Warrants. The Warrant may not be offered, sold,  transferred,  pledged
or  hypothecated  in the absence of any effective  registration  statement as to
such Warrant filed under the Act, or an exemption  from the  requirement of such
registration,  and compliance with the applicable  federal and state  securities
laws. The Company may require an opinion of counsel  satisfactory to the Company
that such registration is not required and that such laws are complied with. The
Company may treat the  registered  holder of this Warrant as he or it appears on
the Company's book at any time as the Holder for all purposes. The Company shall
permit the Holder or his duly authorized  attorney,  upon written request during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing the registered holders of Warrants.

    (o)  Transfer to Comply  With the  Securities  Act of 1933.  The Company may
cause the  following  legend,  or one  similar  thereto,  to be set forth on the
Warrants and on each certificate  representing Warrant Securities,  or any other
security  issued or  issuable  upon  exercise of this  Warrant  not  theretofore
distributed to the public or sold to underwriters for distribution to the public
pursuant  to Sections  (h) or (i) hereof;  unless  counsel  satisfactory  to the
Company is of the opinion as to any such  certificate  that such legend,  or one
similar thereto, is unnecessary:

    "The warrants represented by this certificate are restricted  securities and
may not be offered for sale, sold OR otherwise  transferred unless an opinion of
counsel  satisfactory to the Company is obtained  stating that such offer , sale
or transfer is in compliance wrath state and federal securities law.

(p)  Applicable  Law.  This  Warrant  shall be  governed  by, and  construed  in
accordance  with,  the laws of the State of Colorado,  without  giving effect to
conflict of law principles.

(q) Assignability. This Warrant may not be amended except in a writing signed by
each Holder and the Company.








(r) Survival of Indemnification  Provisions.  The indemnification  provisions of
this Warrant shall survive until _________________ , 2005


                                                       PerArdua Corporation





                                       8



                                                By
                                                   -----------------------------
                                                   Francis O'Donnell , President
Date:
      --------------------



Attest:



- -------------------------
              , Secretary




                                                   Schneider Securities, Inc.

                                                   -----------------------------







                                  PURCHASE FORM



                                                   Dated _____________ 19 ___



                                       9



    The  undersigned  hereby  irrevocably  elects to exercise the Warrant to the
extent of purchasing  shares of Common Stock and Redeemable  Warrants and hereby
makes payment of $________ in payment of the actual exercise price thereof.



                   INSTRUCTIONS FOR REGISTRATION OF SECURITIES



Name
     ---------------------------------------------------------------------------
         (please typewrite or print in block letters)




Address
        ------------------------------------------------------------------------


Signature
          ----------------------------------------------------------------------


                                 ASSIGNMENT FORM



FOR VALUE RECEIVED,
                    ------------------------------------------------------------
hereby sells, assigns and transfers unto

Name
     ---------------------------------------------------------------------------
         (please typewrite or print in block letters)


Address
        ------------------------------------------------------------------------

the right to purchase _____ shares of Common Stock and _____ Redeemable Warrants
as represented by this Warrant to the extent of _____ shares of Common Stock and
_____ Redeemable  Warrants as to which such right is exercisable and does hereby
irrevocably  constitute  and appoint ,  _________________________  attorney,  to
transfer the same on the books of the Company with full power of substitution in
the premises.



Signature
          ----------------------------------------------------------------------


Dated: ________________ 19 __


                                       10



                                                                    EXHIBIT 10.3
                             RESEARCH AGREEMENT #2

This Research  Agreement  ("Agreement")  is entered into by and between PerArdua
Corporation,  a Missouri Corporation  ("Sponsor") and the UNIVERSITY OF SOUTHERN
CALIFORNIA  ("University"),   a  California  nonprofit  educational  institution
incorporated under the laws of the State of California.

RECITALS:

WHEREAS,  the  research  project  contemplated  by this  Agreement  is of mutual
interest  and  benefit  to   UNIVERSITY   and  to  SPONSOR,   will  further  the
instructional,  scholarship  and research  objectives  of UNIVERSITY in a manner
consistent with its status as a nonprofit, tax-exempt,  educational institution,
and may derive  benefits for both  SPONSOR and  UNIVERSITY  through  inventions,
improvements and discoveries;

NOW,  THEREFORE,  in  consideration  of the premises and mutual covenants herein
contained, the parties hereto agree to the following:

1. DEFINITIONS

1.1 "Research"  shall mean the project as described in Appendix A hereof,  under
the direction of Dr. Charles E. McKenna as Principal Investigator.

1.2 "University  Intellectual Property" shall mean individually and collectively
all  inventions,  improvements  and  discoveries,  whether  or  not  covered  by
intellectual  property  protection,  which are  conceived or made by one or more
employees of UNIVERSITY in performance of the Research.

2. RESEARCH WORK

2.1  UNIVERSITY   shall  use   reasonable   efforts  to  perform  such  Research
substantially  in accordance  with the terms and  conditions of this  Agreement.
Anything  in  this  Agreement  to  the  contrary  notwithstanding,  SPONSOR  and
UNIVERSITY may at any time amend the Research by mutual written agreement.

2.2 In the event that the Principal  Investigator becomes unable or unwilling to
continue the Research,  and a mutually  acceptable  substitute is not available,
UNIVERSITY or SPONSOR  shall have the option to terminate  this  Agreement.

2.3  Nothing  in the  Agreement  shall be  construed  to limit  the  freedom  of
researchers,  whether  participants  in this  Agreement or not, from engaging in
similar research inquiries made independently  under other grants,  contracts or
agreements with parties other than SPONSOR.

3. PERIOD OF PERFORMANCE

3.1 The period of  performance  of this  Agreement  is  October 1, 1996  through
September 30, 1997. This Agreement shall become  effective upon the date of last
signature  hereto  and shall  continue  in effect for the full  duration  of the
period of performance.

3.2  No-cost  extension.  Principal  investigator  may,  at his  option,  expend
residual funds as of September 30, 1997 during a 8-month period at no additional
cost to SPONSOR, in the interests of the proposed research.  Funds unexpended on
expiration  of the  extension  period will be returned to SPONSOR.

3.3 Renewal.  Principal Investigator may, at the invitation of SPONSOR, submit a
request for renewal of funding on October 1, 1997 for a specified  period of not
less than one year. 








                  Research Agreement #2 (96): PerArdua Corp. -- USC. Page 2 of 7


4. REPORTS

On March 1, 1997 and every 6 months thereafter, UNIVERSITY shall furnish SPONSOR
a letter report summarizing the work conducted. A final report setting forth the
accomplishments   and  significant   research  findings  shall  be  prepared  by
UNIVERSITY  and submitted to SPONSOR within sixty (60) days of the expiration of
the Agreement.  At option of Sponsor and by mutual agreement with P.I.,  interim
reports may be presented to Sponsor in oral form.

5. COSTS, BILLINGS AND OTHER SUPPORT

5.1 It is agreed and understood by the parties  hereto that,  subject to Article
2, total costs to the SPONSOR hereunder shall not exceed the amount of $177,000,
or the "Total Costs"  specified in the Budget presented in Appendix A, whichever
is less. The entire payment shall be made by SPONSOR in advance of the period of
performance.


5.2 Checks shall be made payable to University of Southern  California  and sent
to:

                 Attn: Mann Bennett
                 University of Southern California
                 Department of Contracts and Grants
                 University Park
                 Los Angeles, CA 90089-1147

5.3 In the event of termination of this Agreement pursuant to Article 12 hereof,
SPONSOR shall pay all costs  accrued by  UNIVERSITY  as of date of  termination,
including  noncancellable  obligations.   Such  obligations  shall  include  all
graduate stipends, postdoctoral appointments, and P.l. summer support called for
in Appendix A. After  termination,  any  obligation  of the SPONSOR for graduate
fellowships and appointments  shall end one year from the date of appointment or
September 30, 1997, whichever is later, but not later than June 1, 1998.

5.4 P.I. budget authority.  P.I. shall have the right to transfer funds from one
budget category to another without prior permission of SPONSOR,  in an amount up
to 25% of the larger of the two categories affected. Transfer of funds exceeding
this  amount will  require  written  agreement  of SPONSOR.  P.I.  may  disburse
budgeted  funds  within  categories  in a  flexible  manner  using the  detailed
budgetary plan given in the Appendix as a reasonable guideline. 

5.5 Any interest  accrued on unexpended  funds provided by SPONSOR to UNIVERSITY
will be added quarterly to the account containing these funds, to be budgeted by
P.I. for the purposes of this project.

6. PUBLICITY

Neither party shall use the name, trade name,  trademark or other designation of
the other  party in  connection  with any  products,  promotion  or  advertising
without the prior written permission of the other party.

7. PUBLICATIONS

UNIVERSITY shall have the right, at its discretion, to release information or to
publish any material  resulting  from the  Research.  UNIVERSITY  shall  furnish
SPONSOR  with a copy of any  proposed  publication  thirty  (30)  days  prior to
submission for  publication.  If SPONSOR  decides to request  UNIVERSITY to file
patent  protection for information  contained in the proposed  publication under
Articles 9 and 10 herein,  SPONSOR may request  UNIVERSITY  to delay  publishing
such proposed publication 


                                      -2-




                  Research Agreement #2 (96): PerArdua Corp. -- USC. Page 3 of 7


for a maximum of an  additional  forty-five  (45) days in order to  protect  the
potential patentability of any invention described therein.

8. CONFIDENTIALITY

8.1 During the course of this  agreement,  SPONSOR may provide  UNIVERSITY  with
certain  information,  data,  or material in writing  which  SPONSOR has clearly
marked as  confidential or proprietary in nature.  UNIVERSITY  shall receive and
hold such information in confidence and agrees to use its reasonable  efforts to
prevent disclosure to third parties of said information in the manner UNIVERSITY
treats  its  own  similar   information. 

8.2  UNIVERSITY  shall  not  consider  information  disclosed  to it by  SPONSOR
confidential  which:  (1) is now common  knowledge or subsequently  becomes such
through  no  breach  of  this  Agreement;  (2)  is  rightfully  in  UNIVERSITY's
possession  prior to SPONSOR's  disclosure as shown by written  records;  (3) is
disclosed to UNIVERSITY by an independent  third party; or (4) is  independently
developed  by or for  UNIVERSITY  without  benefit of  confidential  information
received from SPONSOR.

9. INTELLECTUAL PROPERTY

9.1 All rights and title to University Intellectual Property conceived under the
Research  shall  belong  to  UNIVERSITY  and shall be  subject  to the terms and
conditions of this Agreement.

9.2  UNIVERSITY  will promptly  notify  SPONSOR of any  University  Intellectual
Property  conceived  or made in the  performance  of work under this  Agreement.
SPONSOR shall,  upon reviewing such  notification,  determine whether to request
UNIVERSITY to file, prosecute and maintain any patent application or application
for other intellectual property protection, domestic or foreign, in UNIVERSITY's
name.  SPONSOR shall bear all reasonable  costs incurred in connection with such
preparation,  filing,  prosecution and  maintenance  directed to said University
Intellectual  Property.   UNIVERSITY  shall  keep  SPONSOR  advised  as  to  all
developments  with respect to such  applications  and SPONSOR  shall be given an
opportunity to review and comment thereon.

9.3 If SPONSOR  elects not to exercise its option in accordance  with Article 10
herein or decides to discontinue  the financial  support of the  application for
intellectual  property protection,  UNIVERSITY shall be free to file or continue
prosecution  and  maintenance  on any such  application,  at  UNIVERSITY's  sole
expense  If  SPONSOR  elects  to  discontinue  the  financial   support  of  the
application for  intellectual  property  protection prior to issuance of a valid
patent,  SPONSOR thereby waives and gives up any right it may have under Section
10 below to license University Intellectual Property. 

10. TRANSFER OF RIGHTS

UNIVERSITY granted SPONSOR's predecessor, Per Ardua L.P., an option to a license
to  University  Intellectual  Property  on  commercially  reasonable  terms  and
conditions,  including reasonable royalties,  with a right to sublicense, as was
mutually agreed upon in a separate writing, "Option and License Agreement".  The
right,  title and  interest in and to this  Agreement  has been sold,  assigned,
transferred and conveyed to SPONSOR by PerArdua L.P. under a separate writing of
Assignment, Assumption and Consent, to which UNIVERSITY was a party, wherein the
Option and License Agreement appears as Exhibit A.

11. COPYRIGHTS

All  rights to  copyrightable  materials,  including  computer  software,  first
created during performance of the work funded under this Agreement shall vest in
UNIVERSITY,   with  a   royalty-free   license  to  SPONSOR  for  its   internal
non-commercial  use.  UNIVERSITY  grants  SPONSOR an option to license  any such
material(s) it wishes to develop for commercial purposes on reasonable terms and
conditions, including 


                                      -3-




                  Research Agreement #2 (96): PerArdua Corp. -- USC. Page 4 of 7

commercially  reasonable royalties,  as the parties mutually agree in a separate
writing.  such  option  shall  extend for six (6) months  from the first date of
disclosure to SPONSOR by UNIVERSITY that such material exists.

12. TERMINATION

12.1 parties may terminate this agreement only by mutual written agreement.

12.2  Termination  of this  Agreement  by either  party for any reason shall not
affect the rights and  obligations of the parties accrued prior to the effective
date of termination.

13. WARRANTIES

13.1  UNIVERSITY  makes  no  warranties  as to its  ability  to  accomplish  the
Research, as to the validity of the Research developed under this Agreement,  or
as to the  condition  of any  invention  or  product,  tangible  or  intangible,
conceived,  discovered or developed under this Agreement.

13.2 UNIVERSITY makes no warranties,  express or implied,  of merchantability or
fitness for a  particular  purpose of the  Research or any  invention or product
conceived,  discovered or developed under this Agreement.  Neither the Principal
Investigator,  SPONSOR,  nor any other  person is  authorized  to gin/e any such
warranty in the name of or on behalf of UNIVERSITY. 

13.3  SPONSOR  agrees that it will not rely solely  upon  technical  information
provided by UNIVERSITY or the Principal Investigator in developing any invention
or product, but will independently test, analyze and evaluate all inventions and
products prior to manufacture and  distribution of such inventions and products.

14. INSURANCE AND INDEMNIFICATION

14.1 UNIVERSITY agrees to maintain adequate liability insurance, such protection
being applicable to Officers, employees and agents while acting within the scope
of their  employment  by  UNIVERSITY. 

14.2  SPONSOR  agrees to hold  harmless,  indemnify  and defend  UNIVERSITY  and
Principal  Investigator  from all liabilities,  demands,  damages,  expenses and
losses arising out of  performance  of this  Agreement  (except to the extent of
UNIVERSITY's  active  negligence  or willful  misconduct),  SPONSOR's use of the
Research,  or SPONSOR's use,  manufacture or sale of products or inventions made
by use of the results of the Research  performed  hereunder.  The  provisions of
this paragraph  shall survive  termination of this  Agreement.

15. INDEPENDENT CONTRACTOR

UNIVERSITY is an independent  contractor  under this Agreement and not an agent,
servant,  employee,  associate,  joint  venturer  or  partner  of  SPONSOR.

16. GOVERNING LAW

This  Agreement  shall be governed and construed in accordance  with the laws of
the State of California.  Jurisdiction  and venue of any dispute  arising out of
this  Agreement  shall lie with any court of competent  jurisdiction  within the
County of Los Angeles.

                                      -4-




                  Research Agreement #2 (96): PerArdua Corp. -- USC. Page 5 of 7


17. ATTORNEYS' FEES

In the event  litigation or arbitration is commenced to enforce any of the terms
of this Agreement,  the prevailing party shall recover, as part of the award and
judgment,  its  reasonable  attorneys'  fees  and  costs of such  litigation  or
arbitration from the non-prevailing party.

18. ASSIGNMENT

Neither party shall assign this Agreement  except with the prior written consent
of the other party.

19. WAIVER AND SEVERABILITY

19.1 No waiver by either  party of any  breach  of any  provision  hereof  shall
constitute  a waiver  of any  other  breach  of that or of any  other  provision
hereof.

19.2 In the event a court or governmental agency of competent jurisdiction holds
any provision of this Agreement to be invalid, such holding shall have no effect
on the remaining  provisions of this Agreement,  and they shall continue in full
force and effect.  Upon such  holding,  the parties  shall,  within a reasonable
period of time,  determine  whether the severed  provision(s)  detrimentally and
materially  affect the obligations or performance of either or both parties.  If
so affected, the parties shall, within a reasonable period of time, negotiate in
good  faith  to  modify  this  Agreement  to  relieve  such  effects.   If  such
negotiations do not result in mutually agreeable modification to this Agreement,
notwithstanding  the  provisions of Article 12 herein either  effected party may
terminate  this  Agreement  upon providing the other party with thirty (30) days
written notice of such termination.

20. AGREEMENT MODIFICATION

This  Agreement may be modified or amended,  including  extension of the term of
this  Agreement,  at any  time  only by a  written  amendment  executed  by both
parties.

                                      -5-




                  Research Agreement #2 (96): PerArdua Corp. -- USC. Page 6 of 7


21. NOTICES

Any notices given under this Agreement  shall be in writing and delivered to the
following  addresses by return receipt mail,  postage  prepaid,  or by overnight
courier  service.  Such notices shall be effective  upon the third  business day
following mailing, if by mail, or upon receipt, if by courier.
                 
                                              FOR UNIVERSITY:
FOR SPONSOR:
                                              Nann Bennett
Mr. Samuel P. Sears, Jr.                      Department of Contracts and Grants
(Director & Treasurer, Per Ardua Corporation) Stonier Hall Rm. 330
16 South Market St.                           University of Southern California
Petersburg, VA 23803                          Los Angeles, CA 90089-1147

                                              COPY TO PI:
                                              Dr. Charles E. McKenna
                                              Department of Chemistry
                                              Organic Chemistry Wing Rm. 201
                                              University of Southern California
                                              Los Angeles, CA 90089-0744

22. THIRD PARTY RIGHTS

This  Agreement  shall not  create  any  rights,  including  without  limitation
third-party  beneficiary  rights,  in any  person or entity  not a party to this
Agreement.

                                      -6-




                          Research Agreement: PerArdua, Inc. -- USC. Page 7 of 7

2 3. ENTIRE AGREEMENT

This Agreement  constitutes the entire understanding  between the parties hereto
and there are no collateral,  oral or written agreements or  understandings.

IN WITNESS  WHEREOF,  the parties have  executed  this  Agreement in two or more
counterparts,  each as an original and ail together as one  instrument as of the
date of last signature below written.

PERARDUA CORPORATION                      UNIVERSITY OF SOUTHERN CALIFORNIA

By: /s/ Samuel P. Sears, Jr.              By: /s/ Lloyd Armstrong, Jr.
    ------------------------                  ------------------------

Name: Samuel P. Sears. Jr.                Name: Lloyd Armstrong. Jr.
      --------------------                      --------------------

Title: Director & Treasurer               Title: Provost and Senior V.P.,
       --------------------                      ------------------------
                                                 Academic Affairs
                                                 ------------------------

Date: January 7, 1997                     Date: October 24, 1996
      ---------------                           ----------------


ATTACHMENT: Appendix A (Statement of Work)


                                      -7-

                                                                    EXHIBIT 10.4

                              CONSULTING AGREEMENT

         Agreement ("Agreement") made as of the 30th day of September,  1996, by
and between PerArdua Corporation,  a Missouri corporation ("PerArdua"),  and Dr.
Charles  E.  McKenna,  Ph.D.,  an  individual  residing  in  Pacific  Palisades,
California ("McKenna").

         PerArdua and McKenna hereby agree as follows:

         1.  Consulting  Services.  Subject to the terms and  conditions of this
Agreement,  PerArdua hereby engages McKenna to provide consulting services to it
for the period  beginning on the date of this  Agreement and expiring  September
30, 1999, subject to earlier  termination as hereinafter  provided,  and McKenna
agrees to provide such services.

         2.  Scope of  Services.  (a) It is  understood  that  McKenna  shall be
obligated to provide  consulting  services only upon matters which relate to his
field of professional  expertise and  experience,  namely the field of chemistry
generally and  specifically to any matters relating to the development of a drug
termed Thiovir(TM),  as the parties may mutually agree.  Consulting services may
include,  but shall not be limited  to,  providing  advice and  consultation  to
officers  or  employees  of  PerArdua  or to others  designated  by and having a
relationship with PerArdua, evaluating scientific information, narratives and/or
data and reporting  upon the same to PerArdua,  attending and  participating  in
meetings  pertinent to  PerArdua's  business,  and  otherwise  cooperating  with
PerArdua in a consulting capacity,  all as may be requested from time to time by
PerArdua  and subject to the  limitations  set forth in (b) next below.  McKenna
shall perform his services in Me Los Angeles,  California  metropolitan area and
at such other locations as McKenna and PerArdua  reasonably may agree;  provided
that if PerArdua requests McKenna to perform services outside of the Los Angeles
metropolitan  area,  McKenna  shall use  reasonable  efforts to comply with such
request.

         (b) It is acknowledged by PerArdua that McKenna's principal  occupation
is as a Professor of Chemistry at the University of Southern  California ("USC")
and that, in addition to his  commitments to USC, he will have from time to time
other professional commitments.  McKenna's obligations to PerArdua hereunder are
subject  to his  commitments  to USC,  it being  understood  that  McKenna  will
nevertheless  make a good  faith  effort to make  himself  available  to provide
services hereunder from time to time as may be reasonably requested by PerArdua.
It is further  understood  that in no event will  McKenna be expected to provide
more than one day a week to PerArdua.  Both  parties  shall act in good faith in
arriving at mutually convenient times for the rendering of services hereunder.

         (c) PerArdua  acknowledges that McKenna's services under this Agreement
are in the nature of research and  development  services.  McKenna shall use his
best  judgment  and efforts to timely and  professionally  perform his  services
under this  Agreement.  PerArdua  acknowledges  and agrees that  McKenna can not
guaranty that any of his research efforts and decisions will produce


                                        1


results  directly  beneficial to the development of Thiovir(TM) and that McKenna
shall  not be deemed to be in breach  of this  Agreement  solely  because  it is
subsequently  determined  that  the  research  is  not  successful  or  that  an
alternative course of research would have been more beneficial.

         3. Compensation. (a) PerArdua shall pay to McKenna a retainer of $5,000
for the period  October 1, 1996,  through March 31, 1997,  $5,000 for the period
April 1, 1997,  through  September 30, 1997,  $12,500 for the period  October 1,
1997,  through  September 30, 1998, and $ 15,000 for the period October 1, 1998,
through  September 30, 1999. Such retainer  payments shall be due and payable on
the first day of each applicable period except the first $5,000 payment shall be
made on January 2, 1997.  All amounts  paid and  payable by PerArdua  under this
Section 3 (a) shall be deemed  non-refundable  regardless of circumstances which
may occur after the payment date except that PerArdua  shall not be precluded by
these provisions from seeking or obtaining damages for breach of this agreement.

         (b) In addition to the retainer specified in (a) above,  PerArdua shall
pay to McKenna $ 1,~000 for each day (in excess of four hours) and $600 for each
half day (up to four  hours) of  consulting  services  hereunder.  Travel  time,
unless  after 6:00 p.m.  or before  8:00  a.m.,  shall be added to time spent on
consulting  services  for  purposes of computing  compensation  hereunder.  Such
compensation  shall be paid to McKenna  reasonably  promptly  after  PerArdua is
invoiced  therefor.  Notwithstanding  the  foregoing,  no per diem fees shall be
payable for the following consulting services rendered by McKenna hereunder: (i)
incidental telephone  discussions or other de minimis expenditures of time, (ii)
advice and  consultation  to  PerArdua  and/or its  attorneys,  accountants  and
underwriters,  and  attorney  for  underwriters,  rendered on or before June 30,
1997, and regarding  scientific and  development  matters  pertinent to the drug
Thiovir in connection with the preparation of a registration statement,  and any
amendments thereto, for an initial public offering of PerArdua's securities, and
discussed or to be discussed in such registration statement and amendments,  and
(iii) advice and consultation rendered on or before December 31, 1996, regarding
the  preparation  of protocols  for the testing of, and studies with respect to,
Thiovir pursuant to FDA rules, regulations and guidelines.

         (c) PerArdua shall reimburse  McKenna for his reasonable  out-of-pocket
expenditures  incurred  in  the  performance  of  his  services  hereunder  upon
presentation of appropriate supporting documentation.

         (d) PerArdua shall reimburse  McKenna for legal fees and  disbursements
incurred by him in  connection  with the  negotiation  and  preparation  of this
Agreement up to a maximum of $1,000.

         4. Restrictive  Covenants.  (a) During the Term and for a period of one
year thereafter,  McKenna, whether for himself or as an employee or agent of, or
consultant to,  another person or entity,  shall not be engaged in any activity,
including,  without limitation,  research,  product design, product development,
manufacturing or selling, which involves the development or commercialization of
a specific drug for the treatment of active cytomegalovirus in the human


                                        2

body; provided,  however, that the foregoing restrictions shall not apply to (i)
any acts undertaken pursuant to research grants made to USC by PerArdua, whether
now or hereinafter in effect,  or (ii) any acts undertaken on behalf of PerArdua
pursuant to this  Agreement  or  otherwise,  or (iii) any  "Permitted  Research"
regardless  of the source of the funding  for such  research or the topic of the
research.  For  purposes of this  Section.  "Permitted  Research"  means (I) any
exploratory or general  research that is not oriented towards the development of
any specific drug or treatment for active  cytomegalovirus  in the human body or
for other virus which has been identified by PerArdua as a potential  target for
control by Thiovir or any variation  thereof or synthetic  substitute  therefor,
and (II) any research with respect to which there is no  reasonable  possibility
that the research may result in findings that would relate to a specific drug or
treatment of the type described in (I) above.

         In the event that  McKenna  submits a proposal  for funding or receives
funding to perform any Permitted  Research of the type described in (iii) above,
but which McKenna nevertheless  anticipates may produce results which may relate
to a specific drug for the treatment of cytomegalovirus,  he shall give PerArdua
written  notice  of such  proposal  or  funding  commitment  and  the  following
provisions designated (w) through (z) shall apply:

       (w)    If the proposal is submitted to a government agency,  such as
              NIH,  McKenna shall  deliver to PerArdua,  within thirty (30)
              days after the  submission  of such  proposal,  a copy of the
              title,  abstract and total budget  request and an explanation
              of why  the  proposed  research  is  exploratory  or  general
              research that is permitted under paragraph 4 (a) (iii) above.
              If,  within  thirty  (30)  days  after  its  receipt  of such
              materials  and  statement  from  McKenna,   PerArdua  advises
              McKenna in writing  that it desires to have  McKenna  perform
              such  research for PerArdua and that  PerArdua will fund such
              research, McKenna shall negotiate in good faith with PerArdua
              regarding  the  withdrawal  of such  proposal and  PerArdua's
              sponsorship of the research.

       (x)    If  McKenna  intends  to  submit  to a  government  agency  a
              proposal  for  a  joint  small   business-academic  or  small
              business  research  proposal under the SBIR,  STTR or similar
              program;  McKenna  shall  deliver to PerArdua,  within thirty
              (30) days after the  submission of such  proposal,  a copy of
              the  title,   abstract  and  total  budget   request  and  an
              explanation  of why the proposed  research is  exploratory or
              general  research  that is  permitted  under  paragraph 4 (a)
              (iii) above. If, within thirty (30) days after its receipt of
              such materials and statement from McKenna,  PerArdua  advises
              McKenna in writing  that it desires to have  McKenna  perform
              such   research  with   PerArdua,   McKenna  shall  agree  to
              collaborate with PerArdua as McKenna's small business partner
              on such proposal.

                                        3


       (y)    If McKenna receives from a for-profit entity a commitment for
              funding or  research,  or a request  that he  perform  funded
              research,  of a type  that may be  described  in clause 4 (a)
              (iii)  above  and  other  than  as a  result  of  a  proposal
              described in either of paragraphs (w) and (x) above,  McKenna
              shall  give  PerArdua  written  notice of the  commitment  or
              request  promptly  after his  receipt  of the  commitment  or
              request.  Thereafter,  PerArdua  shall have  thirty (30) days
              within which to advise  McKenna in writing that it desires to
              have  McKenna  perform  such  research  for PerArdua and that
              PerArdua will fund such research.

       (z)    If PerArdua does not provide to McKenna within the applicable
              period  described above such notice and reasonable  assurance
              that the funding will be provided timely,  McKenna thereafter
              may  perform  such  research  without  violating  any  of the
              provisions  of this Section 4,  provided  that noting in this
              Section shall be deemed to relieve McKenna of his obligations
              to  perform  services  for  PerArdua  under  Sections 1 and 2
              hereof.  McKenna  shall not be deemed  to have  breached  any
              obligation under this Agreement solely by reason of his delay
              or  failure  to provide  any  notice  contemplated  in any of
              paragraphs (w), (x) or (y) above.

         (b)  McKenna  shall  not,  during the Term and for a period of five (5)
years thereafter,  disclose to any other party any trade secrets or confidential
information  of PerArdua,  except (i) as may be required by law or  governmental
order,  (ii) such  information  which has already  been made  public  through no
wrongful  act of McKenna,  or which is approved for release by PerArdua or (iii)
such information as is the subject matter of a patent application which has been
abandoned.  For purposes of this Agreement,  all documents marked "CONFIDENTIAL"
or by some similar  legend,  shall be deemed to be  confidential  information or
trade secrets of PerArdua.

         (c) Subject to the  provisions of Section 4 (d) below,  McKenna  agrees
that any inventions,  improvements or modifications  made by him during the Term
hereof and relating in any way to (i) the chemical compound  thiophosphonoformic
acid or any  variation  thereof  or  synthetic  substitute  therefor,  or (ii) a
specific  drug which may be used for the  treatment  of active  cytomegalovirus,
shall be promptly disclosed and shall belong to PerArdua.  McKenna shall execute
and deliver to PerArdua such  instruments of transfer as PerArdua may reasonably
request in order to effect the intent of this provision.

         (d)  PerArdua  acknowledges  and agrees  that  McKenna  is a  Professor
employed at USC, that he is subject to various  agreements with USC and policies
of USC under which he is  obligated  to assign to USC his rights in  inventions,
improvements,  modifications,  trade secrets and other confidential  information
that he may develop or make,  either alone or in connection  with others,  while
employed at USC,  including those arising from his performance of services under
this Agreement, that PerArdua's rights under Section 4 (c) above are subject and
subordinate to


                                        4



McKenna's  obligations  to USC,  and that  McKenna  shall  not be deemed to have
violated  any  provision  of  Section 4 (c) above by reason of his  transfer  or
assignment to USC,  pursuant to the terms of any agreement  between  McKenna and
USC, of any invention,  improvement or  modification  described in this Section.
McKenna  represents  that  attached  hereto is a true and complete  list of each
agreement  between  McKenna and USC and that he has delivered to PerArdua a true
and complete copy  thereof.  PerArdua  acknowledges  that it has had a chance to
review each such agreement.

         5. Early  Termination.  (a) In the event  PerArdua does not complete an
underwritten  public  offering  of  its  securities  in an  amount  of at  least
$4,000,000  on or before June 30, 1997,  then  PerArdua  shall have the right to
terminate this Agreement as of September 30, 1997, by giving to McKenna  written
notice of such termination at any time on or before August 31, 1997.

         (b) If McKenna dies or becomes disabled during the Term, this Agreement
shall  terminate  automatically  on the date of McKenna's death or ten (10) days
after PerArdua  delivers to McKenna written notice of its intention to terminate
this Agreement  pursuant to this Section  because of McKenna's  disability.  For
purposes  of this  Section,  McKenna  shall be  deemed to be  disabled  if he is
unable, by reason of his physical or mental disability,  to discharge his duties
hereunder for a period of three (3) consecutive calendar months.

         (c) PerArdua may terminate this Agreement for "good cause"  relating to
McKenna's actions or omissions.  For purposes of this paragraph,  the term "good
cause" shall include only the following:  (i) McKenna's  continuing and repeated
failure or refusal to perform his material  duties as required by this Agreement
after PerArdua shall have given McKenna written notice specifically  stating the
nature of such  failure or refusal and  affording  McKenna at least  thirty (30)
days to correct  the  specified  act or  omission;  or (ii) the  existence  of a
material  breach by McKenna of any of the material  provisions of this Agreement
after PerArdua shall have given McKenna written notice specifically  stating the
nature of such  breach  and  affording  McKenna  at least  thirty  (30,~ days to
correct such breach.  PerArdua may  terminate  this  Agreement at the end of any
such 30-day period by delivering to McKenna a second notice of  termination  and
this Agreement shall terminate  simultaneously  with the delivery of such second
notice.

         (d) McKenna may terminate this  Agreement for "good cause"  relating to
PerArdua's actions or omissions.  For purposes of this paragraph, the term "good
cause" shall include but not be Limited to, the  existence of a material  breach
by PerArdua of any of the material  provisions of this  Agreement  after McKenna
shall have given PerArdua  written notice stating with specificity the nature of
such breach and  affording  PerArdua at least  thirty (30) days to correct  such
breach.  McKenna  may  terminate  this  Agreement  at the end of any such 30-day
period  by  delivering  to  PerArdua  a second  notice of  termination  and this
Agreement  shall  terminate  simultaneously  with the  delivery  of such  second
notice.

         (e) Upon termination of this Agreement, McKenna shall be entitled to be
paid any unpaid


                                        5


compensation  for  the  period  prior  to  the  date  of  termination  and to be
reimbursed for expenses incurred before the date of termination.  PerArdua shall
pay such compensation and expense  reimbursement to McKenna within ten (10) days
after  the later of the date of  termination  of the  Agreement  and the date on
which  McKenna  delivers  to  PerArdua a  statement  requesting  payment of such
compensation and/or expense reimbursement.

         (f) Except as specifically  provided in this Section 5, in the event of
termination,  all obligations of the parties hereto shall be null and void after
the termination date, including without limitation the retainer payments payable
after the termination  date, but excluding  those  provisions of Section 4 above
which continue after the Term. PerArdua acknowledges and agrees that if PerArdua
terminates this Agreement  because it has not completed an  underwritten  public
offering on or before June 30, 1997,  McKenna's  obligations under Section 4 (a)
hereof shall terminate simultaneously with the termination of this Agreement.

         (g)  "Term" as used in this  Agreement  shall  mean the  period of time
specified in Section 1 of this  Agreement as the same may be earlier  terminated
in accordance with the provisions of this Section 5.

         6.  Relationship  of  Parties.  Both  parties  acknowledge  that  their
relationship created hereby is strictly one of independent  contractors,  and no
employment or agency relationship is created or intended.

         7.  Miscellaneous.  (a) This Agreement shall be governed by the laws of
California.

         (b) This  Agreement  shall be  binding  upon,  and  shall  inure to the
benefit of, the parties hereto and their respective  successors,  assigns, heirs
and representatives.

         8. Insurance.  At such time as PerArdua  obtains any product  liability
insurance  and/or  errors and  omissions  insurance  applicable to its officers,
directors and employees, PerArdua shall use its reasonable efforts to cause such
insurance to apply to and include  McKenna with  respect to his  performance  of
services under this Agreement.

         9.  Arbitration.  Except as provided  below,  any claim or  controversy
arising  out of or  relating  to this  Agreement  shall be  settled  by  binding
arbitration in accordance with the Commercial  Arbitration Rules of the American
Arbitration  Association (the "AAA"),  and judgment on the award rendered by the
arbitrators  may be entered in any court having  jurisdiction.  The  arbitration
shall be held in Los Angeles,  California.  The parties shall jointly select one
arbitrator;  provided  that if the  parties do not agree on a single  arbitrator
within  frozen  (15) days after  delivery of notice of the  commencement  of the
arbitration,  then a single  arbitrator  shall be chosen in accordance  with the
procedures  of the AAA.  The AAA shall be  instructed  to appoint an  arbitrator
within fifteen (15) days of receiving  notice from either party that the parties
could not agree on an arbitrator,  and the arbitrator shall be instructed to use
its best effort to conclude the


                                        6


arbitration  within  thirty  (30)  days of  appointment.  Each  party  shall pay
one-half of the fees of the arbitrator  and the other costs of the  arbitration,
administrative fees and all other fees and costs. Notwithstanding the foregoing,
neither  party shall be obligated to resort to  arbitration  for any  injunction
sought for a breach of Section 4 thereof.  Each party shall use its best efforts
to proceed  with and  conclude  as  expeditiously  as possible  any  arbitration
proceedings pursuant hereto.

          10. Notices.  Any notice or other communication  required or permitted
hereunder shall be in writing and shall be deemed to have been  delivered,  when
served,  if  personally  served,  or five (5) days after  mailing,  if mailed by
certified or registered mail, return receipt requested, or when transmitted,  if
sent by  facsimile,  telex or other  form of  electronic  transmission,  or when
delivered, if delivered by recognized overnight delivery service such as Federal
Express or DHL, in all cases charges  prepaid and  addressed to the  appropriate
party at the address set forth on the  signature  page of this  Agreement  or to
such  other  person or address  as the party may from time to time  furnish  for
purposes of such notice.

       Executed as of the date first above written.

                                 PerArdua: PerArdua Corporation


                                          by: /s/ Samuel P. Sears, Jr.
                                             ------------------------------
                                             Samuel P. Sears, Jr., Treasurer
                                    Address: 16 South Market Street
                                             Petersburg, VA 23803
                                             fax: 804-861-6215


                                  McKenna:   /s/Charles E. McKenna
                                             ------------------------------
                                             Charles E. McKenna, individually
                                    Address: 16625 Pequeno Place
                                             Pacific Palisades, CA  90272
                                             Fax: (213) 740-5401


                                        7



                             AGREEMENTS AND POLICIES

     Set forth below is a list of the written agreements between McKenna and USC
and the written  policies of USC that McKenna has  delivered  to PerArdua  under
Section 4(d) of the Consulting Agreement.

1.   The relevant portions of McKenna's Faculty Contract with USC

2.   The relevant portions of the USC Faculty Handbook,  including Appendices 5,
     6, 7 and 8

3.   The  relevant  portions  of the USC  statement  for  faculty on Conflict of
     Interest in Research: Policy and Procedures.

4.   July  13,  1995  Important  Notice  from  National  Science  Foundation  to
     Presidents of Universities and Colleges and Heads of Other National Science
     Foundation   Grantee   Organizations   regarding   technical   changes   to
     investigator financial disclosure policy


                                                                    EXHIBIT 10.5

                       ASSIGNMENT, ASSUMPTION AND CONSENT

                    This ASSIGNMENT,  ASSUMPTION AND CONSENT (this  "Agreement")
is made and entered into as of this Monday  July,  1996,  by and among  PerArdua
Investors,  L.P.,  a  California  limited  partnership  ("PLP"),  University  of
Southern California,  a California  nonprofit  corporation ("USC"), and PerArdua
Corporation, a Missouri corporation ("PC").


                                 R E C I T A L S

             A. PLP and USC made and entered into that certain  Option & License
Agreement  effective  March 28,  1994,  as amended,  modified  and  supplemented
through the date hereof (the  "License  Agreement"),  a true and correct copy of
which is attached hereto as Exhibit "A";

             B. PLP and PC desire to enter  into an  Option  and Asset  Purchase
Agreement dated July' 8 , 1996 (the "Option Agreement"), pursuant to which PC is
granted an option The "Option") to acquire, among other things, PLP's rights and
obligations under the License Agreement;

             C. Subject to the terms and  conditions  set forth herein,  (i) PLP
desires  to sell,  assign,  transfer  and  convey  all of its  right,  title and
interest in and to the License  Agreement  to PC, (ii) PC desires to acquire all
such rights from PLP and is willing to assume, and fully,  completely and timely
perform, comply with and discharge, each and all of the obligations,  duties and
liabilities of PLP as Licensee (or, if different,  all  obligations,  duties and
liabilities of an assignee) under the License Agreement and (iii) USC is willing
to consent to such assignment by PLP and assumption by PC.

             NOW,  THEREFORE,  in  consideration  of the  premises,  the  mutual
covenants  and  conditions  contained  herein,  and for other good and  valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto do hereby agree as follows:

             1.  Assignment.  For and in  consideration  of the assumption by PC
described  in Section 2 hereof and the  consent  of USC  described  in Section 3
hereof, AND CONDITIONED UPON the exercise of the Option by PC in accordance with
the terms of the Option  Agreement on or before  September  15,  1996,  PLP does
sell, assign, transfer and convey all of its right, title and interest in and to
the License Agreement to PC.

             2.  Assumption.  For and in  consideration of the assignment of PLP
described  in Section 1 hereof and the  consent  of USC  described  in Section 3
hereof, and conditioned upon the exercise of the Option by PC in accordance with
the terms of the Option  Agreement  on or before  September  15,  1996,  PC does
assume, and covenant and agree fully,  completely and timely to perform,  comply
with and discharge each and all of the  obligations,  duties and  liabilities of
PLP as Licensee (or, if different, all obligations, duties and liabilities of an
assignee) under the License Agreement,  including without limitation the payment
of all amounts due to USC under or  pursuant  to the License  Agreement  such as
royalties attorneys' fees, and payments under the Research Agreement between USC
and PLP effective  March 9, 1994, as amended.  PC further agrees to be fully and
completely  bound by each and every term and condition of the License  Agreement
and  expressly  acknowledges  that  no  term,  condition,  obligation,  duty  or
liability under the License Agreement has been waived or excused by USC.

             3. Consent.  For and in  consideration  of, and contingent upon the
assumption  of PC  described  in  Section 2 hereof and the  satisfaction  of the
condition  provided for in Section 4 hereof,  and conditioned upon the execution
of the Option by PC in accordance  with the terms of the Option  Agreement on or
before  September  15,  1996,  and  with  the  understanding  that  neither  the
assignment by PLP nor this consent shall constitute  either (a) a consent to any
further assignment under the License Agreement,  which further assignment may be
accomplished  in and only in  accordance  with  the  provisions  of the  License
Agreement,  or  (b) a  modification  of any of  the  provisions  of the  License
Agreement,  each and all of which  provisions  shall  remain  in full  force and
effect without any modification  whatsoever,  USC does consent to the assignment
by PLP described in Section 1 hereof.

             4.  License  Agreement  Condition.  PLP  and PC  acknowledge  that,
pursuant  to Section  16 of the  License  Agreement,  the  effectiveness  of the
assignment, assumption and consent provided for herein is conditioned upon USC's
receipt of four percent (4%) of the aggregate consideration received by PLP as a
result of its  assignment or transfer to PC,  including  without  limitation all
cash, notes and securities  issued or issuable to PLIP or any of its partners in
consideration for his or her partnership interest in PLP; provided that any such
securities  shall be issued to USC but held by the  Secretary  of PC pursuant to
escrow instructions in form and substance reasonably acceptable to PC and USC.

             5.  Validity of  Agreement.  Notwithstanding  any provision of this
Agreement to the contrary,  in no event shall this Agreement be valid or binding
upon the  parties  hereto  unless  and until the  Option is  exercised  by PC in
accordance with the terms of the Option  Agreement on or before  September 15, 1
996.

          6. Miscellaneous.

             A. Waiver of Breach. No parry's failure to enforce any provision or
provisions of this Agreement shall be deemed or in any way construed as a waiver
of any such  provision or  provisions,  nor prevent that party  thereafter  from
enforcing  each and every  provision of this  Agreement.  The rights granted the
parties  herein are  cumulative and shall not constitute a waiver of any party's
right  to  assert  all  other  legal   remedies   available   to  it  under  the
circumstances.


                                       -2-



             B.  Governing  Law;  Venue.  This  Agreement  shall be construed in
accordance  with and all  disputes  hereunder  shall be governed by the internal
laws of the State of California;  provided,  however, that any provision of this
Agreement  which may be prohibited by or otherwise  held invalid under such laws
shall be  ineffective  only to the extent of such  prohibition or invalidity and
shall not invalidate or otherwise render ineffective any or all of the remaining
provisions  of  this  Agreement.   USC,  PC,  and  PLP  hereby  consent  to  the
jurisdiction  of the courts of the State of  California  and the  United  States
courts located in the County of Los Angeles, State of California,  in connection
with any  lawsuit,  action or  proceeding  arising  out of or  relating  to this
Agreement,  and such courts shall be the only courts having  jurisdiction of any
such controversies.  All parties hereby waive any defense of lack of In personam
jurisdiction, improper venue and forum non conveniens, and agree that service of
process of such court may be made upon each of them by  personal  delivery or by
mailing certified or registered mail, return receipt  requested,  to the parties
at the addresses set forth below.

             C.  Expenses.  If any legal action or other  proceeding  is brought
forth for the enforcement of this Agreement,  or because of an alleged  dispute,
or breach or default in connection with any of the provisions of this Agreement,
the  successful  or  prevailing  party shall be  entitled to recover  reasonable
attorneys'  fees and other  costs  incurred!  in that action or  proceeding,  in
addition to any other relief to which it or they might be entitled.

             D. Counterparts.  This Agreement may be executed  simultaneously in
two (2) or more  counterparts,  each of which shall be deemed to be an original,
but all of which together shall constitute one (1) and the same instrument.

             E. Complete  Agreement;  Amendments.  This  Agreement  contains the
entire understanding among the parties hereto with respect to the subject matter
hereof and supersedes any prior agreements and understandings  relating thereto.
This  Agreement  may not be waived,  changed,  modified,  extended or discharged
orally,  but only by a  written  instrument  signed by the  party  against  whom
enforcement  of any waiver,  change,  modification,  extension  or  discharge is
sought.


[Intentionally left blank]



                                       -3-


             IN WITNESS WHEREOF, the parties hereto have executed this Agreement
in triplicate as of the day and year first above written.




                                      UNIVERSITY OF SOUTHERN CALIFORNIA


                                      By:    Illegible
                                         ---------------------------------
                                      Its: Sr. VP for Administration
                                          --------------------------------     
                                      Address: University Park
                                      Los Angeles, California 90089-1333
 
                    

                                      PERARDUA INVESTORS, L.P.


                                      By:   
                                         --------------------------------
                                      Its:  
                                          -------------------------------
                                      Address: 350 California Street, Suite 1905
                                               San Francisco, California 94104


                                      PERARDUA CORPORATION

                                      By:
                                         --------------------------------  
                                      Its:
                                          -------------------------------
                                      Address: 709 The Hamptons Lane
                                               Town & Country, Missouri 63017



                                      -4-





             IN WITNESS WHEREOF, the parties hereto have executed this Agreement
in triplicate as of the day and year first above written.




                                      UNIVERSITY OF SOUTHERN CALIFORNIA


                                      By:    
                                         ---------------------------------
                                      Its: 
                                          --------------------------------     
                                      Address: University Park
                                      Los Angeles, California 90089-1333
 
                    

                                      PERARDUA INVESTORS, L.P.


                                      By:   Illegible
                                         --------------------------------
                                      Its:  President and CEO of General Partner
                                            PerArdua, II
                                          -------------------------------
                                      Address: 350 California Street, Suite 1905
                                               San Francisco, California 94104


                                      PERARDUA CORPORATION

                                      By:
                                         --------------------------------  
                                      Its:
                                          -------------------------------
                                      Address: 709 The Hamptons Lane
                                               Town & Country, Missouri 63017




                                      -4-





             IN WITNESS WHEREOF, the parties hereto have executed this Agreement
in triplicate as of the day and year first above written.




                                      UNIVERSITY OF SOUTHERN CALIFORNIA


                                      By:    
                                         ---------------------------------
                                      Its:
                                          --------------------------------
                                      Address: University Park
                                      Los Angeles, California 90089-1333
 
                    

                                      PERARDUA INVESTORS, L.P.


                                      By:   
                                         --------------------------------
                                      Its:  
                                          -------------------------------
                                      Address: 350 California Street, Suite 1905
                                               San Francisco, California 94104


                                      PERARDUA CORPORATION

                                      By: /s/ Samuel P. Sears, Jr.
                                         --------------------------------  
                                      Its: Treasurer
                                          -------------------------------
                                      Address: 709 The Hamptons Lane
                                               Town & Country, Missouri 63017





                                      -4-


                                                                    EXHIBIT 10.6

                              PERARDUA CORPORATION

                              CONSULTING AGREEMENT
                              --------------------

                       ,1997

Dear Mr. O'Donnell:

         This will  confirm  the  arrangements,  terms and  conditions,  whereby
Schneider Securities,  Inc..  (hereinafter referred to as "Consultant") has been
retained  by you to  serve as  financial  consultant  and  advisor  to  PerArdua
Corporation (hereinafter referred to as the "Company"),  on a nonexclusive basis
for a period of 36 months  commencing on the closing date of the public offering
(the  "Closing").  The  undersigned  hereby  agree to the  following  terms  and
conditions:

     1. Consulting  Services.  Consultant will render  financial  consulting and
advice pertaining to the Company's business affairs as you may from time to time
request.

     2.  Financing.  Consultant  will assist and represent you in obtaining both
short and  long-term  financing  whether from banks or the sale of the Company's
debt or equity.

     3. Wall Street Liaison.  Consultant will when appropriate  arrange meetings
with individuals and financial  institutions in the investment community such as
security analysts,  portfolio managers, and market makers and representatives of
the Company.

     4. Compensation. The Company agrees to pay the Consultant in the aggregate,
the sum of One hundred-eight  thousand  ($108,000)  Dollars at the rate of Three
Thousand  ($3,000) Dollars per month with the full amount payable at the closing
of the Offering.

     5. Relationship.  Nothing herein shall constitute Consultant as employee or
agent of the Company except to such extent as might hereafter be agreed upon for
a particular purpose. Except as expressly agreed, Consultants shall not have the
authority to obligate or commit the Company in any manner whatsoever.

    6. Assignment and Termination. This Agreement shall not be assignable by any
party except to successors to all or substantially all of the business of either
the  Consultant  or the Company nor may this  Agreement be  terminated by either
party for any reason  whatsoever  without the prior written consent of the other
party, which consent may not be arbitrarily  withheld by the party whose consent
is required.


Very truly yours,



Schneider Securities, Inc.
By:

Title:

Agreed and Accepted By:
PerArdua Corporation

By:
      Francis O'Donnell., President



                                                                    EXHIBIT 10.7

                              EMPLOYMENT AGREEMENT

         AGREEMENT,  dated and  effective as of September 3, 1996 by and between
PerArdua Corporation,  a Missouri corporation,  (the "Company") and Mary Anthony
Gray,  an individual  with an ADDRESS AT 10538  STRATHMORE  Drive,  Los Angeles,
California 90024 ("Executive"). 

                                  WITNESSETH:

         WHEREAS,  the Executive is willing to serve as Executive Vice President
and Chief  Operating  Officer of the Company,  and the Company desires to retain
the Executive in such capacities THE TERMS AND conditions herein set forth;

         NOW,  THEREFORE,  in  consideration  of  the  mutual  covenants  herein
contained,  and  other  good  and  valuable  consideration.,   the  receipt  and
sufficient y of which are hereby  acknowledged,  the parties hereto hereby agree
as follows:

         1. Employment; Position and Duties; Extent: of Services.
                   
                   (a)  Employment.  The Company agrees to employ the Executive,
and the Executive agrees to be employed by the Company, for the Term provided in
Section 2 below and upon the other terms and conditions hereinafter provided.
                   
                   (b)  Position  and  Duties.  During  the Term as  defined  in
Section  2  herein,  the ]  executive  agrees  to  serve as the  Executive  Vice
President  and Chief  Operating  Officer  of the  Company  and to  perform  such
reasonable  duties  consistent  with such  position as may be  delineated by the
Chief  Executive  Officer and as may be assigned to her from time to time by the
Board of Directors and/or Chief Executive Officer of the Company.
                   
                   (c) Extent  of-  Services.  During  the Term,  and except for
illness or  incapacity,  THE EXECUTIVE  SHALL DEVOTE NOT less than  seventy-five
percent (75%) of her business time, attention,  skill AND eFFORTS EXCLUSIVELY to
the business  and affairs of the  Company,  shall not be engaged in any business
activity in  violation of Section 6 of this  Agreement  or which would  conflict
with her  obligations  hereunder,  and  shall  perform  and  discharge  well and
faithfully  the  duties  which may be  ASSIGNED  TO HER FROM TIME to time by the
Chief  Executive  Officer  and/or Board of Directors;  PROVIDED,  HOWEVER,  THAT
NOTHING  IN  THIS  Agreement  shall  preclude  the  Executive  from  devoting  r
reasonable  time  during  reasonable  periods  required  for  any  or all of the
following:


                                        1



                   (i)  serving as a director  or member of a  committee  of any
other  company or  organization  involving no actual or  potential  conflict of'
interest with the Company or any of its subsidiaries or affiliates;

                   (ii) engaging in charitable and community activities;
                           
                   (iii)  investing  her personal  assets in  businesses in such
form or manner as will not require any SERVICES on the part of the  Executive in
the operation or affairs of such businesses; and/or

                   (iv)  serving  as  biotechnology   transfer  advisor  to  the
University of Southern California in a manner similar to the period prior to her
employment with the Company.
         
         At the request of the Company,  the Executive  shall advise the Company
of the nature and identity of other business organizations or endeavors in which
she may be involved.

         2. Term of Employment.

         The Company  hereby agrees to employ the  Executive,  and the Executive
hereby agrees to accept such employment in the capacity set forth herein,  for a
period of time commencing on the Monday  following the date on which the Company
shall have  completed a  $1,000,000  private  placement  of its Common  Stock to
investors (the "Commencement Date"), but if the Commencement Date shall not have
occurred on or prior to October 31, 1996,  then this Agreement shall be null and
void and of no further  force and  effect..  The term shall  continue  after the
Commencement  Date  until  the  first to occur of the  following:  (i) the first
anniversary  of  the  Commencement   Date,  or  (ii)  the  closing  date  of  an
underwritten  initial public offering of the Company's securities which Offering
has been registered with the Securities and Exchange  Commission  pursuant to Me
registration  provisions of the  Securities  Act of 1933, as amended;  provided,
however,  that either party may terminate  this agreement at any time by written
notice to the other  given at least  ninety  (90) days prior to the  termination
date specified in such written notice.  The Company agrees that, at least thirty
days prior to the anticipated expiration of the term specified  hereinabove,  it
will,  if the  Executive so desires,  negotiate in good faith with the Executive
regarding  continued  employment  beyond  said  expiration  date  pursuant  to a
compensation  arrangement  which would include a performance  bonus in the event
the Executive refers to the Company,  and the company acquires or obtains rights
to or an  exclusive  license  to,  products  or  rights  to  products  which are
complementary to products or rights then possessed by the Company.



                                        2



         3. Compensation.
                  
         As compensation the Executive for all services to be rendered by her in
any capacity hereunder, the Company shall pay a monthly salary at a rate of Five
Thousand and no/100 Dollars ($5,000.00)  payable twice monthly.  Executive shall
be entitled to four (4) weeks paid vacation per year. In additions promptly upon
commencement of Executive's  employment hereunder the Company shall grant to her
incentive  stock options to purchase lO,OOO shares at a price of $7.50 per share
and fully vesting one year after said commencement date.


         4. Location.

         Executive  shall  maintain  an office  at,  and shall  work out of, her
residence in Los Angeles,  California or such other residence that she maintains
from time to time in the United  States.  The Company shall pay to Executive the
sum of One Thousand  Dollars  ($1,000) each month to defray the costs of such an
office and, in addition to such monthly payment, shall provide and pay labor the
following:  a separate telephone line dedicated to the affairs of the Company; a
separate  telephone  facsimile  line  defeated  to the  affairs of the  Company;
appropriate  telephone and facsimile e equipment;  a personal computer and modem
as may be acceptable to the Company in its discretion reasonably exercised;  any
computer  software  acceptable  to  the  Company  in its  discretion  reasonably
exercised;  and such other office  supplies and  equipment as may be approved in
advance by the  Company.  The  Company is riot  obligated  to provide any office
furniture.

         5. Trade Secrets and Confidential Information.

         (a) Definition. As used in this Agreement (i) "Confidential Information
and  Trade  Secrets"  means  all  information,  processes,  process  parameters,
methods,  practices,  chemical  and  other  formulae,   fabrication  techniques,
technical  plans,  algorithms,  computer  programs  and  related  documentation,
customer  lists,  price  lists,  supplier  lists,   marketing  plans,  financial
information,  and all other  compilations  of  information  which  relate to the
business of the  Company and which have not been  released by the Company to the
general public,  but shall not include general technical and business skills and
expertise  which  Executive  has  acquired  or  developed  by  reason  of  prior
experience,  and  (ii) a  "Business  Competitive  with  the  Company"  means  an
enterprise  which is engaged in the  development  or  promotion  of a product or
service which may be reasonablely  considered to compete,  or have the potential
to compete,  in the marketplace  with a product or service which the Company has
been developing or promoting, or has had plans to develop or promote, at anytime
during the Executive's employment hereunder.

         (b) Respective Covenants.

         (i) EXECUTIVE acknowledges that during the term of employment with the




                                        3





Company,  Executive  will Awe to and  become  acquainted  with the  Confidential
Information  and Trade  Secrets of the Company.  Executive  agrees not to use or
disclose (directly or indirectly) any Confidential Information and Trade Secrets
of the Company at any time or in any manner,  e except as required in the course
of employment with the Company. The obligations of this paragraph are continuing
and survive the  termination of  Executive's  employment  with the Company.  All
documents  and  equipment  relating  to the  business  of the  Company,  whether
prepared by Executive or otherwise coming into Executive's  possession,  are the
exclusive property of the Company,  and must not be removed from the premises of
the Company except as required in the course of employment with the Company. All
such  documents  arid  equipment  must be returned to the Company when Executive
leaves the employment of the Company.
                  

         (ii) While employed by the Company,  Executive  agrees not to undertake
any  planning  for any  outside  business  which  would  constitute  a  Business
Competitive with the Company.
                  

         (iii)  While  employed by the Company and for five (5) years after that
employment  ends,  Executive  agrees  not to enter  into any  employment  with a
Business  Competitive with the Company in which the complete  fulfillment of the
duties of the  competitive  employment  would  inherently  require  Executive to
reveal  or use any of the  Confidential  Information  and Trade  Secrets  of the
Company learned or obtained by Executive while employed by the Company.
                  

         (iv) While  employed  by the  Company and for five (5) years after that
employment  ends,  Executive  agrees  not to divert  or  attempt  to divert  (by
solicitation or by any other means) the customers of the Company existing at the
time Executive's employment ends.

         (c)  No  Conflict.   

              The  Company   acknowledges   and  agrees  that  the   Executive's
activities  as  biotechnology  transfer  advisor to the  University  of Southern
California  shall  not  be in  conflict  with  any  of the  provisions  of  this
agreement.

         6. Miscellaneous.

              (a) Successors and Assigns.  This Agreement is intended to benefit
and is binding on (i) the  successors  and  assigns of the  Company and (ii) the
heirs and legal successors of executive.

              (b) governing law. this agreement shall be construed in accordance
with and governed by the laws of the state of california.



                                        4


              (c) Separate  Enforcement of Provisions.  If for any reason a part
of this  Agreement is  unenforceable,  The remainder of the  Agreement  shall be
enforced to the extent possible.

              (d) Modification of Agreement. This Agreement may only be modified
by a writing signed (i) by Executive and (ii) by an authorized representative of
the Company.
  
              (e) No Conflicting Contracts.  Executive represents that Executive
has no  contracts  with any other party that would  interfere  with  Executive's
compliance with the terms and conditions of this Agreement

              (f) No  Right  to  Continuing  Employment.  No  provision  of this
Agreement shall be construed as giving Executive the right to be retained in the
employment  of the  Company,  except to the  extent  express"  set forth in this
Agreement.


Executed as of the date first above  written.
                                                       
/S/ Mary Anthony Gray
- ---------------------------------------------         PerArdua Corporation
Mary Anthony Gray                                  
                                                    By: /S/ Samuel P. Sears, Jr.
                                                      -------------------------
                                                           Treasurer





                                                                    EXHIBIT 23.1


                        CONSENT OF INDEPENDENT AUDITORS


      We hereby consent to the use in this Registration Statement of our report,
dated  January  24,  1997,  relating  to the  financial  statements  of PerArdua
Corporation, and to the reference to our Firm under the caption "Experts" in the
Prospectus.





                                      MCGLADREY & PULLEN, LLP


Richmond, Virginia 
February 5, 1997





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