TRIANGLE PHARMACEUTICALS INC
SC 13D/A, 1996-12-30
PHARMACEUTICAL PREPARATIONS
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<PAGE>



                          SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, D.C. 20549

                                    SCHEDULE 13D/A

                      UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                  (AMENDMENT NO. 1)



                            TRIANGLE PHARMACEUTICALS, INC.                     
- --------------------------------------------------------------------------------
                                   (NAME OF ISSUER)


                      COMMON STOCK, PAR VALUE $0.001 PER SHARE                 
- --------------------------------------------------------------------------------
                            (TITLE OF CLASS OF SECURITIES)


                                      89589H104
- --------------------------------------------------------------------------------
                                    (CUSIP NUMBER)

                                 STANDISH M. FLEMING
                                     IVOR ROYSTON
                                 C/O FORWARD VENTURES
                                 10975 TORREYANA ROAD
                                      SUITE 230
                                 SAN DIEGO, CA 92121
                                   (619) 677-6077                             
- --------------------------------------------------------------------------------
                    (NAME, ADDRESS AND TELEPHONE NUMBER OF PERSON
                  AUTHORIZED TO RECEIVE NOTICES AND COMMUNICATIONS)


                                  DECEMBER 20, 1996
- --------------------------------------------------------------------------------
               (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)


    If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box / /.

    Check the following box if a fee is being paid with the statement / /.  (A
fee is not required only if the reporting person:  (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.) 
(See Rule 13d-7.)


                            (Continued on following pages)



                                  PAGE 1 OF 35 PAGES

<PAGE>

- ------------------------------              ------------------------------
CUSIP NO.  89589H104              13D       Page 2 of 35 Pages  
- ------------------------------              ------------------------------
- --------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    STANDISH M. FLEMING             
- --------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                            (a) / /   (b) / /
- --------------------------------------------------------------------------------
3   SEC USE ONLY

- --------------------------------------------------------------------------------
4   SOURCE OF FUNDS*
         PF, AF
- --------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
    REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)                                / /
- --------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION
         USA
- --------------------------------------------------------------------------------
                   7    SOLE VOTING POWER
NUMBER                       62,798
OF            -----------------------------------------------------------------
SHARES             8    SHARED VOTING POWER
BENEFICIALLY                 1,708,663++
OWNED BY      -----------------------------------------------------------------
REPORTING          9    SOLE DISPOSITIVE POWER
PERSON                       62,798
WITH          -----------------------------------------------------------------
                   10   SHARED DISPOSITIVE POWER
                             1,708,663++
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                             1,771,461++
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                          / /
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
                             10.1%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
                   IN
- --------------------------------------------------------------------------------

                   *SEE INSTRUCTIONS BEFORE FILLING OUT!

++  1,475,000 of these shares are held by Forward Ventures II, L.P., of which
    Forward II Associates, L.P. is the general partner, of which Mr. Fleming is
    a general partner.  An additional 233,663 of these shares are held by
    Forward Ventures III, L.P., of which Forward III Associates, L.L.C. is the
    general partner, of which Mr. Fleming is a managing member.  Mr. Fleming
    disclaims beneficial ownership of these 1,708,663 shares other than to the
    extent of his individual partnership and member interests.


                                  PAGE 2 OF 35 PAGES

<PAGE>

- ------------------------------              ------------------------------
CUSIP NO.  89589H104              13D       Page 3 of 35 Pages
- ------------------------------              ------------------------------
- --------------------------------------------------------------------------------
1   NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    IVOR ROYSTON          
- --------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                            (a) / /  (b) / / 
- --------------------------------------------------------------------------------
3   SEC USE ONLY

- --------------------------------------------------------------------------------
4   SOURCE OF FUNDS*
         PF, AF
- --------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
    REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)                                / /
- --------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION
         USA
- --------------------------------------------------------------------------------
                   7    SOLE VOTING POWER
NUMBER                       0
OF            -----------------------------------------------------------------
SHARES             8    SHARED VOTING POWER
BENEFICIALLY                 1,777,119++
OWNED BY      -----------------------------------------------------------------
REPORTING          9    SOLE DISPOSITIVE POWER
PERSON                       0
WITH          -----------------------------------------------------------------
                   10   SHARED DISPOSITIVE POWER
                             1,777,119++
- --------------------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                             1,777,119++
- --------------------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                          / /
- --------------------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
                             10.1%
- --------------------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
                        IN
- --------------------------------------------------------------------------------

                        *SEE INSTRUCTIONS BEFORE FILLING OUT!

++  1,475,000 of these shares are held by Forward Ventures II, L.P., of which
    Forward II Associates, L.P. is the general partner, of which Dr. Royston is
    a general partner.  An additional 233,663 of these shares are held by
    Forward Ventures III, L.P., of which Forward III Associates, L.L.C. is the
    general partner, of which Dr. Royston is a managing member.  Dr. Royston
    disclaims beneficial ownership of these 1,708,663 shares other than to the
    extent of his individual partnership and member interests.


                                  PAGE 3 OF 35 PAGES

<PAGE>


    This Amendment No. 1 to Schedule 13D amends the Schedule 13D initially
filed on November 12, 1996 (collectively, with all amendments thereto, the
"Schedule 13D") and reports the recent dissolution of Forward Ventures Vanguard
Fund ("Forward Vanguard") (of which Forward Ventures III, L.P. was a general
partner, of which Forward III Associates, L.L.C. is the general partner, of
which Mr. Fleming and Dr. Royston are managing members) and the distribution of
the 500,000 shares of Common Stock, $0.001 par value per share (the "Common
Stock"), of Triangle Pharmaceuticals, Inc., a Delaware corporation (the
"Issuer"), held by Forward Vanguard to its general partners, Forward Ventures
III, L.P. (233,663 shares) and another unrelated entity (266,337 shares), upon
the dissolution of Forward Vanguard.
    
    The Schedule 13D is hereby amended by this Amendment No. 1 to Schedule 13D
as follows:
    
ITEM 2.  IDENTITY AND BACKGROUND
    
    Item 2 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows:  
    
    Pursuant to Rule 13d-1(f) promulgated under the Securities Exchange Act of
1934, as amended (the "Exchange Act"), the undersigned hereby jointly file this
statement on Amendment No. 1 to Schedule 13D on behalf of: (i) Standish M.
Fleming, a member of the Board of Directors of the Issuer and a general partner
of Forward Ventures, a venture capital firm ("Forward Ventures"), and (ii) Ivor
Royston, the President of the Sidney Kimmel Cancer Center, a general partner of
Forward Ventures and a Co-Trustee of both the Royston Family Trust UTD March 18,
1992 (the "Royston Family Trust") and the Royston Family Children's Trust (the
"Royston Children's Trust").  Mr. Fleming and Dr. Royston are sometimes
hereinafter referred to collectively as the "Reporting Persons."  Mr. Fleming
beneficially owns Common Stock individually and may also be deemed to
beneficially own additional Common Stock as a result of his position as a
general partner (through other entities) of two partnerships affiliated with
Forward Ventures.  Dr. Royston beneficially owns Common Stock in his capacity as
a Co-Trustee of the Royston Family Trust and the Royston Children's Trust and
may also be deemed to beneficially own additional Common Stock as a result of
his position as a general partner (through other entities) of two partnerships
affiliated with Forward Ventures.  Mr. Fleming and Dr. Royston are making this
single, joint filing to comply with the reporting requirements with respect to
Common Stock of the Issuer that each beneficially owns.
    
    Forward Ventures is affiliated with several separate partnerships, two of
which beneficially own Common Stock of the Issuer:  Forward Ventures II, L.P., a
Delaware limited partnership (sometimes hereafter referred to as "Forward II"),
and Forward Ventures III, L.P., a Delaware limited partnership (sometimes
hereafter referred to as "Forward III").  Forward II Associates, L.P. is the
general partner of Forward II and Mr. Fleming and Dr. Royston are the general
partners of Forward II Associates, L.P.  Forward III Associates, L.L.C. is the
general partner of Forward III and Mr. Fleming and Dr. Royston are the managing
members of Forward III Associates, L.L.C.  As a result of their positions as
general partners of Forward II Associates, L.P. and managing members of Forward
III Associates, L.L.C., Mr. Fleming and Dr. Royston may be deemed pursuant to
Rule 13d-3 to beneficially own the Common Stock owned by Forward II and Forward
III.  Mr. Fleming and Dr. Royston, however, disclaim beneficial ownership of the
shares owned by Forward II and Forward III other than to the extent of their
individual partnership and member interests.
    
A.  Standish M. Fleming -- Individual
    ---------------------------------

    (a)  Standish M. Fleming.
    
    (b)  Business address:  10975 Torreyana Road, Suite 230, San Diego, CA
92121.


                                  PAGE 4 OF 35 PAGES

<PAGE>

    (c)  Present principal occupation:  General Partner of Forward Ventures
(private investor).
    
    (d)-(e)  Standish M. Fleming has not, during the last five years, been
convicted in any criminal proceeding, excluding traffic violations or similar
misdemeanors, nor been a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction as a result of which he was or is
subject to a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities laws
or finding any violation with respect to such laws.
    
    (f)  Citizenship:  USA.

B.  IVOR ROYSTON -- INDIVIDUAL
    
    (a)  Ivor Royston.
    
    (b)  Business address:  3099 Science Park Road, Suite 200, San Diego, CA
92121.

    (c)  Present principal occupation:  President of the Sidney Kimmel Cancer
Center.
    
    (d)-(e) Ivor Royston has not, during the last five years, been convicted in
any criminal proceeding, excluding traffic violations or similar misdemeanors,
nor been a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction as a result of which he was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.
    
    (f)  Citizenship:  USA.
    
    
ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION
    
    Item 3 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows: 
    
    Mr. Fleming used $3,605 of his personal funds to purchase the Issuer's
Common Stock acquired by Mr. Fleming as set forth in Item 5(c)(1) of this
Schedule 13D.
    
    Dr. Royston, as a Co-Trustee of the Royston Family Trust, used $30,405 of
such trust's funds to purchase the Issuer's Common Stock acquired by the Royston
Family Trust as set forth in Item 5(c)(2)(A) and (B) of this Schedule 13D.  Dr.
Royston, as a Co-Trustee of the Royston Children's Trust, used $29,780 of such
trust's funds to purchase the Issuer's Common Stock acquired by the Royston
Children's Trust as set forth in Item 5(c)(2)(C) of this Schedule 13D.
    
    Forward II used $1,253,750 of its partnership funds to purchase the
Issuer's securities acquired by Forward II as set forth in Item 5(c)(3)(A) of
this Schedule 13D.
    
    Forward III received the Issuer's securities acquired by Forward III as set
forth in Item 5(c)(3)(B) of this Schedule 13D as a result of the dissolution of
Forward Vanguard and the distribution of its assets to its general partners. 
Forward III acquired its partnership interest in Forward Vanguard by purchasing
the partnership interest previously held by Forward New Opportunities Limited
for $250 and contributing an additional $1,249,750 to Forward Vanguard.  Of
these funds, $250,000 were partnership funds of Forward III, and $1,000,000 were
funds Forward III borrowed from Silicon Valley Bank.  The loan from Silicon
Valley Bank is secured by all of the Issuer's securities held by Forward III. 
Forward Vanguard used $2,500,000 of its


                                  PAGE 5 OF 35 PAGES


<PAGE>

funds to purchase the Issuer's securities acquired by Forward Vanguard as set
forth in Item 5(c)(3)(B) of this Schedule 13D.
    
    
ITEM 4.       PURPOSE OF TRANSACTION
    
    Item 4 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows: 
    
    Mr. Fleming acquired the Common Stock as set forth in Item 5(c)(1) of this
Schedule 13D for investment purposes.  Mr. Fleming initially purchased 62,500
shares of the Issuer's Common Stock on November 8, 1995, which he holds
individually.  Mr. Fleming made an additional purchase of 298 shares of the
Issuer's Common Stock as part of the Issuer's initial public offering ("IPO") on
November 1, 1996, which Common Stock Mr. Fleming also holds individually.
    
    Dr. Royston in his capacity as a Co-Trustee of each of the Royston Family
Trust and the Royston Children's Trust (collectively "Royston Trusts") acquired
the Common Stock as set forth in Item 5(c)(2) of this Schedule 13D for trust
investment purposes.  As a Co-Trustee, Dr. Royston initially purchased 62,500
shares of the Issuer's Common Stock on November 8, 1995, which he beneficially
owns indirectly.  Dr. Royston made an additional purchase as a Co-Trustee on
behalf of the Royston Trusts in the amount of 2,978 shares of the Issuer's
Common Stock for each of the Royston Trusts as part of the Issuer's IPO on
November 1, 1996, which shares Dr. Royston also beneficially owns indirectly.
    
    Forward II acquired the Issuer's securities as set forth in Item 5(c)(3) of
this Schedule 13D for investment purposes.  Forward III acquired its partnership
interest in Forward Vanguard for investment purposes, and now holds the Issuer's
securities it received upon the dissolution of Forward Vanguard as set forth in
Item 5(c)(3) of this Schedule 13D for investment purposes.  Forward Vanguard
acquired the Issuer's securities as set forth in Item 5(c)(3) of this Schedule
13D for investment purposes.  The Reporting Persons may be deemed pursuant to
Rule 13d-3 to beneficially own the Issuer's securities held by Forward II and
Forward III (the "Forward Funds"), although each of the Reporting Persons
disclaims beneficial ownership of the shares held by the Forward Funds other
than to the extent of his individual partnership and member interests.
    
         (a)  None.

         (b)  None.

         (c)  None.

         (d)  None.

         (e)  None. 
    
         (f)  None.
    
         (g)  None.
    
         (h)  None.
    
         (i)  None.
    
         (j)  None.


                                  PAGE 6 OF 35 PAGES

<PAGE>

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER

    Item 5 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows:
    
    (a)  Mr. Fleming beneficially owns 62,798 shares of Common Stock
individually and may be deemed to beneficially own an additional 1,708,663
shares of Common Stock by virtue of his shared voting and dispositive power over
these shares which are held by the Forward Funds.  Mr. Fleming's total
beneficial ownership of 1,771,461 shares represents 10.1% of the outstanding
Common Stock of the Issuer (calculated pursuant to Rule 13d-3(d)(1)).

         Dr. Royston, as a Co-Trustee of each of the Royston Trusts,
beneficially owns an aggregate of 68,456 shares of Common Stock and may be
deemed to beneficially own an additional 1,708,663 shares of Common Stock by
virtue of his shared voting and dispositive power over these shares which are
held by the Forward Funds.  Dr. Royston's total beneficial ownership of
1,777,119 shares represents 10.1% of the outstanding Common Stock of the Issuer
(calculated pursuant to Rule 13d-3(d)(1)).
    
         Forward II beneficially owns 1,475,000 shares of Common Stock. 
Forward II's total beneficial ownership of 1,475,000 shares represents 8.4% of
the outstanding Common Stock of the Issuer (calculated pursuant to Rule 13d-
3(d)(1)).
    
         Forward III beneficially owns 233,663 shares of Common Stock.  Forward
III's total beneficial ownership of 233,663 shares represents 1.3% of the
outstanding Common Stock of the Issuer (calculated pursuant to Rule 13d-
3(d)(1)).
    
    (b)  Mr. Fleming has sole power to vote and dispose of 62,798 shares of
Common Stock.  In addition, as a result of his position as a general partner of
Forward II Associates, L.P., the general partner of Forward II, and a managing
member of Forward III Associates, L.L.C., the general partner of Forward III,
Mr. Fleming shares voting and dispositive power over the 1,475,000 shares of
Common Stock held by Forward II and over the 233,663 shares of Common Stock held
by Forward III, respectively.  Mr. Fleming disclaims beneficial ownership of the
1,708,663 shares held by the Forward Funds other than to the extent of his
individual partnership and member interests.
    
         Dr. Royston, as a Co-Trustee of each of the Royston Trusts, shares
voting and dispositive power over an aggregate 68,456 shares of Common Stock. 
In addition, as a result of his position as a general partner of Forward II
Associates, L.P., the general partner of Forward II, and a managing member of
Forward III Associates, L.L.C., the general partner of Forward III, Dr. Royston
shares voting and dispositive power over the 1,475,000 shares of Common Stock
held by Forward II and over the 233,663 shares of Common Stock held by Forward
III, respectively.  Dr. Royston disclaims beneficial ownership of these
1,708,663 shares held by the Forward Funds other than to the extent of his
individual partnership and member interests.
    
    (c)  No other transactions in the Issuer's securities were effected by the
Reporting Persons, or the entities whereby the Reporting Person's derive
beneficial ownership of the Issuer's securities, except for the following:
    
         (1)  MR. FLEMING

              A.   Mr. Fleming acquired 62,500 shares of Common Stock at a
price of $0.01 per share from the Issuer on November 8, 1995.
    
              B.   Mr. Fleming acquired 298 shares of shares of Common Stock at
a price of $10.00 per share from the Issuer on November 1, 1996.


                                  PAGE 7 OF 35 PAGES


<PAGE>

    Mr. Fleming now directly owns 62,798 shares or 0.36% of the outstanding
Common Stock of the Issuer.  Mr. Fleming acquired such shares for investment
purposes and has sole voting and dispositive power over these shares.
    
         (2)  DR. ROYSTON
    
              A.   Dr. Royston, as a Co-Trustee of the Royston Family Trust,
acquired 62,500 shares of Common Stock at a price of $0.01 per share from the
Issuer on November 8, 1995.
    
              B.   Dr. Royston, as a Co-Trustee of the Royston Family Trust,
acquired 2,978 shares of Common Stock at a price of $10.00 per share from the
Issuer on November 1, 1996.
    
              C.   Dr. Royston, as a Co-Trustee of the Royston Children's
Trust, acquired 2,978 shares of Common Stock at a price of $10.00 per share from
the Issuer on November 1, 1996.
    
    As a Co-Trustee of each of the Royston Trusts, Dr. Royston beneficially
owns an aggregate of 68,456 shares or 0.39% of the outstanding Common Stock of
the Issuer.  Dr. Royston acquired such shares in his capacity as a Co-Trustee of
the Royston Trusts for trust investment purposes and shares voting and
dispositive power over these shares along with the other Co-Trustee of each of
the Royston Trusts.
    
         (3)  FORWARD II AND FORWARD III
    
              A.   On July 19, 1995, Forward II acquired 375,000 shares of
Common Stock at a price of $0.01 per share and 666,667 shares of the Issuer's
Series A Preferred Stock, par value $0.001 per share (the "Series A Preferred"),
at a price of $0.75 per share.  On November 8, 1995, Forward II acquired an
additional 333,333 shares of the Issuer's Series A Preferred at a price of $0.75
per share.  On June 11, 1996, Forward II acquired 100,000 shares of the Issuer's
Series B Preferred Stock, par value $0.001 per share (the "Series B Preferred"),
at a price of $5.00 per share.  All of the outstanding shares of the Issuer's
Series A Preferred and Series B Preferred were converted on a one-for-one basis
into shares of the Issuer's Common Stock upon the completion of the Issuer's
IPO.  As a result, as of the date of this Schedule 13D Forward II beneficially
owns 1,475,000 shares or 8.4% of the outstanding Common Stock of the Issuer. 
Both Mr. Fleming and Dr. Royston share voting and dispositive power with respect
to the shares of Common Stock beneficially owned by Forward II, but disclaim
beneficial ownership of these shares other than to the extent of their
individual partnership interests.
    
              B.   On June 11, 1996, Forward Vanguard acquired 500,000 shares
of the Issuer's Series B Preferred at a price of $5.00 per share.  All of the
outstanding shares of the Issuer's Series B Preferred were converted on a one-
for-one basis into shares of the Issuer's Common Stock upon the completion of
the Issuer's IPO.  On December 20, 1996, Forward Vanguard was dissolved and the
500,000 shares of the Issuer's Common Stock held by Forward Vanguard were
distributed to its general partners, Forward III (233,663 shares) and another
unrelated entity (266,337 shares).  Both Dr. Royston and Mr. Fleming share
voting and dispositive power with respect to the 233,663 shares of Common Stock
beneficially owned by Forward III, but disclaim beneficial ownership of these
shares other than to the extent of their individual member interests.
    
    (d)  No other person is known to have the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the sale of, the
shares of Common Stock beneficially owned (or deemed to be beneficially owned)
by the Reporting Persons.


                                  PAGE 8 OF 35 PAGES


<PAGE>

    (e)  Not applicable.
    
    
ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT
         TO SECURITIES OF THE ISSUER
    
    Item 6 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows: 
    
    (a)  The Reporting Persons hold the shared voting and dispositive power
over the 1,708,663 shares of Common Stock beneficially owned by the Forward
Funds pursuant to written agreements with the Forward Funds and their partners. 
The pertinent portions of these agreements are filed as exhibits to this
Schedule 13D.
    
    (b)  Forward III received the Issuer's securities acquired by Forward III
as set forth in Item 5(c)(3)(B) of this Schedule 13D as a result of the
dissolution of Forward Vanguard and the distribution of its assets to its
general partners.  Forward III acquired its partnership interest in Forward
Vanguard by purchasing the partnership interest previously held by Forward New
Opportunities Limited for $250 and contributing an additional $1,249,750 to
Forward Vanguard.  Of these funds, $250,000 were partnership funds of Forward
III, and $1,000,000 were funds Forward III borrowed from Silicon Valley Bank. 
The loan from Silicon Valley Bank is secured by all of the Issuer's securities
held by Forward III.
    
    
ITEM 7.       MATERIAL TO BE FILED AS EXHIBITS
    
    Item 7 as reported on the Schedule 13D is hereby amended and restated in
its entirety as follows: 
    
    (a)  Agreement of Joint Filing dated December 30, 1996, between Standish M.
Fleming and Ivor Royston.
    
   +(b)  Relevant portions of the Forward Ventures II, L.P. Amended and
Restated Limited Partnership Agreement dated September 21, 1993.
    
    (c)  Relevant portions of the Forward Ventures III, L.P. Limited
Partnership Agreement dated August 30, 1996.
    
    (d)  Loan and Security Agreement dated December 19, 1996, between Forward
Ventures III, L.P. and Silicon Valley Bank.
    
    (e)  Pledge Agreement dated December 1996, between Forward Ventures III,
L.P. and Silicon Valley Bank.



- --------------------
+   Incorporated by reference to the same numbered exhibit to the Schedule 13D
    (No. 005-47359) filed with the Commission on November 12, 1996.


                                  PAGE 9 OF 35 PAGES

<PAGE>

SIGNATURE
    
    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
    
    
December 30, 1996
    
                                       /s/ Standish M. Fleming
                                       ----------------------------------------
                                       STANDISH M. FLEMING
    
    
                                       /s/ Ivor Royston
                                       ----------------------------------------
                                       IVOR ROYSTON



ATTENTION:    Intentional misstatements or omissions of fact constitute Federal
              criminal violations (SEE 18 U.S.C. 1001).


                                 PAGE 10 OF 35 PAGES

<PAGE>

 EXHIBIT INDEX


    7(a)   Agreement of Joint Filing dated December 30, 1996, between Standish
           M. Fleming and Ivor Royston.
   +7(b)   Relevant portions of the Forward Ventures II, L.P. Amended and
           Restated Limited Partnership Agreement dated September 21, 1993.
    7(c)   Relevant portions of the Forward Ventures III, L.P. Limited
           Partnership Agreement dated August 30, 1996.
    7(d)   Loan and Security Agreement dated December 19, 1996, between Forward
           Ventures III, L.P. and Silicon Valley Bank.
    7(e)   Pledge Agreement dated December 1996, between Forward Ventures III,
           L.P. and Silicon Valley Bank.



- --------------------
+   Incorporated by reference to the same numbered exhibit to the Schedule 13D
    (No. 005-47359) filed with the Commission on November 12, 1996.


                                 PAGE 11 OF 35 PAGES




<PAGE>

                                                                    Exhibit 7(a)

                              AGREEMENT OF JOINT FILING



    The undersigned hereby agree that they are filing jointly pursuant to Rule
13d-1(f)(1) of the Securities Exchange Act of 1934, as amended, the Amendment
No. 1 to Schedule 13D dated December 30, 1996 containing the information
required by Schedule 13D for the shares of Common Stock of Triangle
Pharmaceuticals, Inc. held by the undersigned individuals and which Amendment
No. 1 to Schedule 13D amends the original Schedule 13D filed by the undersigned
on November 12, 1996.




December 30, 1996


                                       /s/ Standish M. Fleming
                                       -----------------------------------
                                       STANDISH M. FLEMING


                                       /s/ Ivor Royston
                                       -----------------------------------
                                       IVOR ROYSTON



























                    [Signature Page of Agreement of Joint Filing]

                                 PAGE 12 OF 35 PAGES

<PAGE>

                                                                    Exhibit 7(c)

                             FORWARD VENTURES III, L.P.,
                            a Delaware limited partnership

                            LIMITED PARTNERSHIP AGREEMENT


    This Agreement is made and entered into as of the 30th day of August, 1996,
by and among Forward III Associates L.L.C., a Delaware limited liability company
(the "General Partner"), and each of the persons and entities the names of which
are set forth under the heading "Limited Partners" on the Schedule of Partners
attached hereto, which hereby form Forward Ventures 111, L.P., a Delaware
limited partnership (the "Partnership or "Forward III"), pursuant to the
Delaware Revised Uniform Limited Partnership Act, as follows:

                                      ARTICLE I.

                                 NAME, CHARACTER, AND
                           PRINCIPAL OFFICE OF PARTNERSHIP

    1.1  PARTNERSHIP NAME.  The name of the Partnership is Forward Ventures
111, L.P. The partners of the Partnership are the General Partner and the,
Limited Partners (the "Partners").  The affairs of the Partnership shall be
conducted under the Partnership name or such other name as the General Partner
may, in its discretion, determine.

    1.2  PARTNERSHIP PURPOSE.  The primary purpose of the Partnership is to
make venture capital investments, principally by investing in equity or
equity-oriented securities of privately-held, early-stage emerging biotechnology
and health care related companies.  The Partnership may also participate in,
among other things, leveraged acquisitions of privately held and publicly held
corporations (or divisions, subsidiaries or other business units thereof) and
investments in securities of publicly held corporations that appear to be
undervalued or that offer the opportunity for significant capital appreciation. 
The general purposes of the Partnership are to buy, hold, sell, and otherwise
invest in Securities, whether readily marketable or not; to exercise all rights,
powers, privileges, and other incidents of ownership or possession with respect
to Securities held or owned by the Partnership-, to enter into, make, and
perform all contracts and other undertakings; and to engage in all activities
and transactions as may be necessary, advisable, or desirable, as determined by
the General Partner, to carry out the foregoing.

    1.3  PRINCIPAL OFFICE; REGISTERED OFFICE.  The principal office of the
Partnership shall be 10975 Torreyana Road, Suite 230, San Diego, California
92121, or such other place or places within the United States as the General
Partner may from time to time designate.  The Partnership's registered office in
Delaware, and the name of the registered agent for service of process, shalt be
The Corporation Trust Company, Corporation Trust Center, 1209 Orange Street,
Wilmington, Delaware 19801 or such other place or persons as the General Partner
may from time to time designate.


                                       . . . .


                                 PAGE 13 OF 35 PAGES

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                                     ARTICLE VII.

                         MANAGEMENT, DUTIES, AND RESTRICTIONS

    7.1  MANAGEMENT.  The General Partner shall have the sole and exclusive
right to manage, control, and conduct the affairs of the Partnership and to do
any and all acts on behalf of the Partnership (including exercise of rights to
elect to adjust the tax basis of Partnership assets and to revoke such elections
and to make such other tax elections as the General Partner shall deem
appropriate).

    7.2  INDEBTEDNESS; RESTRICTIONS; REINVESTMENTS.

    (a)  Without the consent of the Advisory Committee, the General Partner may
not borrow money or otherwise incur indebtedness on behalf of the Partnership or
guaranty indebtedness of companies of which the Partnership holds Securities in
an amount in excess of one million dollars ($1,000,000); PROVIDED THAT no
borrowing or guaranty shall be made by the Partnership if the Limited Partners
would be required to. recognize unrelated business taxable income within the
meaning of Section 512 of the Code as a result thereof.

    (b)  Except with the approval of the Advisory Committee, the Partnership
shall not invest: (i) more than ten percent (10%) of the aggregate amount of the
Partners' Capital Commitments to the Partnership in the Securities of any one
issuer; PROVIDED THAT such restriction shall not prohibit the investment of up
to one million five hundred thousand dollars ($1,500,000) nor permit the
investment of more than four million dollars ($4,000,000) in the Securities of
any one issuer; (ii) in Securities in the over-the-counter market or in
Securities that are listed on a securities exchange or (iii) in partnerships
with investment objectives similar to those of the Partnership.

    (c)  The Partnership shall not reinvest any proceeds realized on the sale
of Securities in the Partnership's venture capital portfolio; provided that such
proceeds may be reinvested in (i) Money Market Investments and (ii) Securities
other than Money Market Investments provided that the Partnership's cumulative
investment in Securities other than Money Market Investments over the term of
the Partnership shall not exceed one hundred ten percent (110%) of the Partners'
Capital Commitments to the Partnership.

    (d)  The Partnership shall not invest primarily in leveraged acquisitions
of privately or publicly held corporations.


                                       . . . .

                                 PAGE 14 OF 35 PAGES



<PAGE>

                                                                    Exhibit 7(d)


SILICON VALLEY BANK


                             LOAN AND SECURITY AGREEMENT



BORROWER:     FORWARD VENTURES III, L.P.

ADDRESS:      10975 TORREYANA ROAD, SUITE 230
              SAN DIEGO, CA  92121

DATE:         DECEMBER 19, 1996

THIS LOAN AND SECURITY AGREEMENT is entered into on the above date between
SILICON VALLEY BANK ("Silicon"), whose address is 3003 Tasman Drive, Santa
Clara, California 95054 and the borrower named above (the "Borrower"), whose
chief executive office is located at the above address ("Borrower's Address").

1.  LOANS.

    1.1  LOANS.  Silicon, in its reasonable discretion, will make loans to the
Borrower (the "Loans") in amounts determined by Silicon in its reasonable
discretion up to the amount (the "Credit Limit") shown on the Schedule to this
Agreement (the "Schedule"), provided no Event of Default and no event which,
with notice or passage of time or both, would constitute an Event of Default has
occurred.  The Borrower is responsible for monitoring the total amount of Loans
and other Obligations outstanding from time to time, and Borrower shall not
permit the same, at any time, to exceed the Credit Limit.  If at any time the
total of all outstanding Loans and all other Obligations exceeds the Credit
Limit, the Borrower shall immediately pay the amount of the excess to Silicon,
without notice or demand.

    1.2  INTEREST.  All Loans and all other monetary Obligations shall bear
interest at the rate shown on the Schedule hereto.  Interest shall be payable
monthly, on the due date shown on the monthly billing from Silicon to the
Borrower.  Silicon may, in its discretion, charge interest to Borrower's deposit
accounts maintained with Silicon.

    1.3  FEES.  The Borrower shall pay to Silicon a loan origination fee in the
amount shown on the Schedule hereto concurrently herewith.  This fee is in
addition to all interest and other sums payable to Silicon and is not
refundable.

    1.4  LETTERS OF CREDIT.  [Not Applicable]

2.  GRANT OF SECURITY INTEREST

    2.1  OBLIGATIONS.  The term "Obligations" as used in this Agreement means
the following:  the obligation to pay all Loans and interest thereon when due,
and to pay and perform when due all other present and future indebtedness,
liabilities, obligations, guarantees, covenants, agreements, warranties and
representations of the Borrower to Silicon, whether joint or several, monetary
or non-monetary, and whether created pursuant to this Agreement or any other
present or future agreement or otherwise.  Silicon may, in its discretion,
require that Borrower pay monetary Obligations in cash to 

                                 PAGE 15 OF 35 PAGES


<PAGE>

Silicon, or charge them to Borrower's Loan account, in which event they will
bear interest at the same rate applicable to the Loans.  Silicon may also, in
its discretion, charge any monetary Obligations to Borrower's deposit accounts
maintained with Silicon.  Silicon will notify the Borrower of any such charges
to Borrower's deposit accounts.  Such charges shall not be deemed to be a setoff
for any purpose.

    2.2  COLLATERAL.  As security for all Obligations, the Borrower hereby
grants Silicon a continuing security interests in all of the Borrower's interest
in the types of property described below, whether now owned or hereafter
acquired, and wherever located (collectively, the "Collateral"): (a) All
accounts, contract rights, chattel paper, letters of credit, documents,
securities, money, and instruments, and all other obligations now or in the
future owing to the Borrower;(b) All inventory, goods, merchandise, materials,
raw materials, work in process, finished goods, farm products, advertising,
packaging and shipping materials, supplies, and all other tangible personal
property which is held for sale or lease or furnished under contracts of service
or consumed in the Borrower's business, and all warehouse receipts and other
documents; and (c) All equipment, including without limitation all machinery,
fixtures, trade fixtures, vehicles, furnishings, furniture, materials, tools,
machine tools, office equipment, computers and peripheral devices, appliances,
apparatus, parts, dies, and jigs;(d) All general intangibles including, but not
limited to, deposit accounts, goodwill, names, trade names, trademarks and the
goodwill of the business symbolized thereby, trade secrets, drawings,
blueprints, customer lists, patents, patent applications, copyrights, security
deposits, loan commitment fees, federal, state and local tax refunds and claims,
all rights in all litigation presently or hereafter pending for any cause or
claim (whether in contract, tort or otherwise), and all judgments now or
hereafter arising therefrom, all claims of Borrower against Silicon, all rights
to purchase or sell real or personal property, all rights as a licensor or
licensee of any kind, all royalties, licenses, processes, telephone numbers,
proprietary information, purchase orders, and all insurance policies and claims
(including without limitation credit, liability, property and other insurance),
and all other rights, privileges and franchises of every kind;(e) All books and
records, whether stored on computers or otherwise maintained; and (f) All
substitutions, additions and accessions to any of the foregoing, and all
products, proceeds and insurance proceeds of the foregoing, and all guaranties
of and security for the foregoing; and all books and records relating to any of
the foregoing.  Silicon's security interest in any present or future technology
(including patents, trade secrets and other technology) shall be subject to any
licenses or rights now or in the future granted by the Borrower to any third
parties in the ordinary course of Borrower's business; provided that if the
Borrower proposes to sell, license or grant any other rights with respect to any
technology in a transaction that, in substance, conveys a major part of the
economic value of that technology, Silicon shall first be requested to release
its security interest in the same, and Silicon may withhold such release in its
discretion.*

* THE COLLATERAL SHALL ALSO INCLUDE, WITHOUT LIMITATION, THE RIGHTS OF THE
BORROWER TO RECEIVE AND REQUIRE CAPITAL CONTRIBUTIONS FROM ITS PARTNERS, AND
SUCH ACTUAL CAPITAL CONTRIBUTIONS, WHETHER NOW EXISTING OR HEREAFTER ARISING,
INCLUDING, WITHOUT LIMITATION, RIGHTS TO CAPITAL CONTRIBUTIONS FROM IT PARTNERS
ALREADY ACCRUED BUT NOT RECEIVED UNDER THE LIMITED PARTNERSHIP AGREEMENT OF
BORROWER DATED AUGUST 30, 1996, AS AMENDED, MODIFIED OR SUPPLEMENTED FROM TIME
TO TIME (COLLECTIVELY, THE "CAPITAL CONTRIBUTIONS").

3.  REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE BORROWER.

    The Borrower represents and warrants to Silicon as follows, and the
Borrower covenants that the following representations will continue to be true,
and that the Borrower will comply with all of the following covenants:

                                 PAGE 16 OF 35 PAGES


<PAGE>

    3.1  EXISTENCE AND AUTHORITY.  The Borrower is and will continue to be,
duly authorized, validly existing and in good standing under the laws of the
jurisdiction of its organization.  The Borrower is and will continue to be
qualified and licensed to do business in all jurisdictions in which any failure
to do so would have a material adverse effect on the Borrower.  The execution,
delivery and performance by the Borrower of this Agreement, and all other
documents contemplated hereby have been duly and validly authorized, are
enforceable against the Borrower in accordance with their terms, and do not
violate any law or any provision of, and are not grounds for acceleration under
Borrower's partnership agreement, any agreement relating to the Borrower's
acquisition of the Shares (as defined in the Schedule hereto) or any other
agreement or instrument which is binding upon the Borrower.  Borrower has no
subsidiaries except as set forth on the Schedule.

    3.2  NAME; TRADE NAMES AND STYLES.  The name of the Borrower set forth in
the heading to this Agreement is its correct name.  Listed on the Schedule
hereto are all prior names of the Borrower and all of Borrower's present and
prior trade names.  The Borrower shall give Silicon 15 days' prior written
notice before changing its name or doing business under any other name.  The
Borrower has complied, and will in the future comply, with all laws relating to
the conduct of business under a fictitious business name.

    3.3  PLACE OF BUSINESS; LOCATION OF COLLATERAL.  The address set forth in
the heading to this Agreement is the Borrower's chief executive office.  In
addition, the Borrower has places of business and Collateral is located only at
the locations set forth on the Schedule to this Agreement.  The Borrower will
give Silicon at least 15 days prior written notice before changing its chief
executive office or locating the collateral at any other location.

    3.4  TITLE TO COLLATERAL; PERMITTED LIENS.  The Borrower is now, and will 
at all times in the future be, the sole owner of all the Collateral, except 
for items of equipment which are leased by the Borrower.  The Collateral now 
is and will remain free and clear of any and all liens, charges, security 
interests, encumbrances and adverse claims, except for the following 
("Permitted Liens"): (i) purchase money security interests in specific items 
of equipment; (ii) leases of specific items of equipment; (iii) liens for 
taxes not yet payable; (iv) additional security interests and liens consented 
to in writing by Silicon in its reasonable discretion, which consent shall 
not be unreasonably withheld; and (v) security interests being terminated 
substantially concurrently with this Agreement.  Silicon will have the right 
to require, as a condition to this consent under subparagraph (iv) above, 
that the holder of the additional security interest or lien sign an 
intercreditor agreement on Silicon's then standard form, acknowledge that the 
security interest is subordinate to the security interest in favor of 
Silicon, and agree not to take any action to enforce its subordinate security 
interest so long as any Obligations remain outstanding, and that the Borrower 
agree that any uncured default in any obligation secured by the subordinate 
security interest shall also constitute an Event of Default under this 
Agreement.  Silicon now has, and will continue to have, a perfected and 
enforceable security interest in all of the Collateral, subject only to the 
Permitted Liens, and the Borrower will at all times defend Silicon and the 
Collateral against all claims of others.  None of the Collateral now is or 
will be affixed to any real property in such a manner, or with such intent, 
as to become a fixture.

    3.5  MAINTENANCE OF COLLATERAL.  The Borrower will maintain the Collateral
in good working condition, and the Borrower will not use the Collateral for any
unlawful purpose.  the Borrower will immediately advise Silicon in writing of
any material loss or damage to the Collateral.

                                 PAGE 17 OF 35 PAGES


<PAGE>

    3.6  BOOKS AND RECORDS.  The Borrower has maintained and will maintain at
the Borrower's Address complete and accurate books and records, comprising an
accounting system in accordance with generally accepted accounting principles.

    3.7  FINANCIAL CONDITION AND STATEMENTS.  All financial statements now or
in the future delivered to Silicon have been, and will be, prepared in
conformity with generally accepted accounting principles and now and in the
future will completely and accurately reflect the financial condition of the
Borrower, at the times and for the periods therein stated.  Since the last date
covered by any such statement, there has been no material adverse change in the
financial condition or business of the Borrower.  The Borrower is now and will
continue to be solvent.  The Borrower will provide Silicon: (i) within 45 days
after the end of each quarter, a quarterly financial statement prepared by the
Borrower; and (ii) within 120 days following the end of the Borrower's fiscal
year, complete annual financial statements, certified by independent certified
public accountants acceptable to Silicon and accompanied by the unqualified
report thereon by said independent certified public accountants.

    3.8  TAX RETURNS AND PAYMENTS; PENSION CONTRIBUTIONS.  The Borrower has
timely filed, and will timely file, all tax returns and reports required by
foreign, federal, state and local law, and the Borrower has timely paid, and
will timely pay, all foreign, federal, state and local taxes, assessments,
deposits and contributions now or in the future owed by the Borrower.  The
Borrower may, however, defer payment of any contested taxes, provided that the
Borrower (i) in good faith contests the Borrower's obligation to pay the taxes
by appropriate proceedings promptly and diligently instituted and conducted,
(ii) notifies Silicon in writing of the commencement of, and any material
development in, the proceedings, and (iii) posts bonds or takes any other steps
required to keep the contested taxes from becoming a lien upon any of the
Collateral.  The Borrower is unaware of any claims or adjustments proposed for
any of the Borrower's prior tax years which could result in additional taxes
becoming due and payable by the Borrower.  The Borrower has paid, and shall
continue to pay all amounts necessary to fund all present and future pension,
profit sharing and deferred compensation plans in accordance with their terms,
and the Borrower has not and will not withdraw from participation in, permit
partial or complete termination of, or permit the occurrence of any other event
with respect to, any such plan which could result in any liability of the
Borrower, including, without limitation, any liability to the Pension Benefit
Guaranty Corporation or its successors or any other governmental agency.

    3.9  COMPLIANCE WITH LAW.  The Borrower has complied, and will comply, in
all material respects, with all provisions of all foreign, federal, state and
local laws and regulations relating to the Borrower, including, but not limited
to, those relating to the Borrower's ownership of real or personal property,
conduct and licensing of the Borrower's business, and environmental matters.

    3.10 LITIGATION.  Except as disclosed in the Schedule, there is no claim,
suit, litigation, proceeding or investigation pending or (to the best of the
Borrower's knowledge) threatened by or against or affecting the Borrower in any
court or before any governmental agency (or any basis therefor known to the
Borrower) which may result, either separately or in the aggregate, in any
material adverse change in the financial condition or business of the Borrower,
or in any material impairment in the ability of the Borrower to carry on its
business in substantially the same manner as it is now being conducted.  The
Borrower will promptly inform Silicon in writing of any claim, proceeding,
litigation or investigation in the future threatened or instituted by or against
the Borrower involving amounts in excess of $100,000.

                                 PAGE 18 OF 35 PAGES


<PAGE>

    3.11 USE OF PROCEEDS.  All proceeds of all Loans shall be used solely for
lawful business purposes.

4.  ADDITIONAL DUTIES OF THE BORROWER.

    4.1  FINANCIAL AND OTHER COVENANTS.  The Borrower shall at all times comply
with the financial and other covenants set forth in the Schedule to this
Agreement.

    4.2  OVERADVANCE; PROCEEDS OF ACCOUNTS.  If for any reason the total of all
outstanding Loans and all other Obligations exceeds the Credit Limit, without
limiting Silicon's other remedies, and whether or not Silicon declares an Event
of Default, Borrower shall remit to Silicon all checks and other proceeds of
Borrower's accounts and general intangibles, in the same form as received by
Borrower, within one day after Borrower's receipt of the same, to be applied to
the Obligations in such order as Silicon shall determine in its discretion.

    4.3  REPORTS.  The Borrower shall provide Silicon with such written reports
with respect to the Borrower (including without limitation budgets, sales
projections, operating plans and other financial documentation), as Silicon
shall from time to time reasonably specify.

    4.4  ACCESS TO COLLATERAL, BOOKS AND RECORDS.  At all reasonable times, and
upon one business day notice, Silicon, or its agents, shall have the right to
inspect the Collateral, and the right to audit and copy the Borrower's
accounting books and records and Borrower's books and records relating to the
Collateral.  Silicon shall take reasonable steps to keep confidential all
information obtained in any such inspection or audit, but Silicon shall have the
right to disclose any such information to its auditors, regulatory agencies, and
attorneys, and pursuant to any subpoena or other legal process.  The foregoing
audits shall be at Silicon's expense, except that the Borrower shall reimburse
Silicon for its reasonable out of pocket costs for semi-annual accounts
receivable audits by Silicon, its agents, or third parties retained by Silicon,
and Silicon may debit Borrower's deposit accounts with Silicon for the cost of
such semi-annual accounts receivable audits (in which event Silicon shall send
notification thereof to the Borrower).  Notwithstanding the foregoing, after the
occurrence of an Event of Default all audits shall be at the Borrower's expense.

    4.5  NEGATIVE COVENANTS.  Except as may be permitted in the Schedule 
hereto, the Borrower shall not, without Silicon's prior written consent, do 
any of the following:  (i) merge or consolidate with another corporation, 
except that the Borrower may merge or consolidate with another corporation if 
the Borrower is the surviving corporation in the merger and the aggregate 
value of the assets acquired in the merger do not exceed 25% of Borrower's 
Tangible Net worth (as defined in the Schedule) as of the end of the month 
prior to the effective date of the merger, and the assets of the corporation 
acquired in the merger are not subject to any liens or encumbrances, except 
Permitted Liens; (ii) acquire any assets outside the ordinary course of 
business for an aggregate purchase price exceeding 25% of the Borrower's 
Tangible Net Worth (as defined in the Schedule) as of the end of the month 
prior to the effective date of the acquisition; (iii) enter into any other 
transaction outside the ordinary course of business (except as permitted by 
the other provisions of this Section); (iv) sell or transfer any Collateral, 
except for the sale of finished inventory in the ordinary course of the 
Borrower's business, and except for the sale of obsolete or unneeded 
equipment in the ordinary course of business; (v) make any loans of any money 
or any other assets other than in accordance with the ordinary course of 
Borrower's business, consistent with past practices; (vi) incur any debts, 
outside the ordinary course of business, which would have a material, adverse 
effect on the Borrower or on the prospect of repayment of the

                                 PAGE 19 OF 35 PAGES


<PAGE>

Obligations; (vii) guarantee or otherwise become liable with respect to the
obligations of another party or entity; (viii) pay or declare any dividends on
the Borrower's stock (except for dividends payable solely in stock of the
Borrower); (ix) redeem, retire, purchase or otherwise acquire, directly or
indirectly, any of the Borrower's stock; (x) make any change in the Borrower's
capital structure which has a material adverse effect on the Borrower or on the
prospect of repayment of the Obligations; or (xi) dissolve or elect to dissolve.
Transactions permitted by the foregoing provisions of this Section are only
permitted if no Event of Default and no event which (with notice or passage of
time or both) would constitute an Event of Default would occur as a result of
such transaction.

    4.6  LITIGATION COOPERATION.  Should any third-party suit or proceeding be
instituted by or against Silicon with respect to any Collateral or in any manner
relating to the Borrower, the Borrower shall, without expense to Silicon, make
available the Borrower and its officers, employees and agents and the Borrower's
books and records to the extent that Silicon may deem them reasonably necessary
in order to prosecute or defend any such suit or proceeding.

    4.7  VERIFICATION.  Silicon may, from time to time, following prior
notification to Borrower, verify directly with the respective account debtors
the validity, amount and other matters relating to the Borrower's accounts, by
means of mail, telephone or otherwise, either in the name of the Borrower or
Silicon or such other name as Silicon may reasonably choose, provided that no
prior notification to Borrower shall be required following an Event of Default.

    4.8  EXECUTE ADDITIONAL DOCUMENTATION.  The Borrower agrees, at its
expense, on request by Silicon, to execute all documents in form satisfactory to
Silicon, as Silicon, may deem reasonably necessary or useful in order to perfect
and maintain Silicon's perfected security interest in the Collateral, and in
order to fully consummate all of the transactions contemplated by this
Agreement.

5.  TERM.

    5.1  MATURITY DATE.  This Agreement shall continue in effect until the
maturity date set forth on the Schedule hereto (the "Maturity Date").

    5.2  EARLY TERMINATION.  This Agreement may be terminated, without penalty,
prior to the Maturity Date as follows:  (i) by the Borrower, effective three
business days after written notice of termination is given to Silicon; or
(ii) by Silicon at any time after the occurrence of an Event of Default, without
notice, effective immediately.

    5.3  PAYMENT OF OBLIGATIONS.  On the Maturity date or on any earlier
effective date of termination, the Borrower shall pay and perform in full all
Obligations, whether evidenced by installment notes or otherwise, and whether or
not all or any part of such Obligations are otherwise then due and payable. 
Without limiting the generality of the foregoing, if on the Maturity date, or on
any earlier effective date of termination, there are any outstanding letters of
credit issued by Silicon or issued by another institution based upon an
application, guarantee, indemnity or similar agreement on the part of Silicon,
then on such date Borrower shall provide to Silicon cash collateral in an amount
equal to the face amount of all such letters of credit plus all interest, fees
and cost due or to become due in connection therewith, to secure all of the
Obligations relating to said letters of credit, pursuant to Silicon's then
standard form cash pledge agreement.  Notwithstanding any termination of this
Agreement, all of Silicon's security interests in all of the Collateral and all
of the terms and provisions of this Agreement shall continue in full force and
effect until all Obligations have been paid and performed in full; 

                                 PAGE 20 OF 35 PAGES


<PAGE>

provided that, without limiting the fact that Loans are subject to the
reasonable discretion of Silicon, Silicon may, in its sole discretion, refuse to
make any further Loans after termination.  No termination shall in any way
affect or impair any right or remedy of Silicon, nor shall any such termination
relieve the Borrower of any Obligation to Silicon, until all of the Obligations
have been paid and performed in full.  Upon payment and performance in full of
all the Obligations, Silicon shall promptly deliver to the Borrower termination
statements, requests for reconveyance and such other documents as may be
required to fully terminate any of Silicon's security interests.

6.  EVENTS OF DEFAULT AND REMEDIES.

    6.1  EVENTS OF DEFAULT.  The occurrence of any of the following events
shall constitute an "Event of Default" under this Agreement, and the Borrower
shall give Silicon immediate written notice thereof: (a) Any warranty,
representation, statement, report or certificate made or delivered to Silicon by
the Borrower or any of the Borrower's officers, employees or agents, now or in
the future, shall be untrue or misleading in any material respect; or (b) the
Borrower shall fail to pay when due any Loan or any interest thereon or any
other monetary Obligation; or (c) the total Loans and other Obligations
Outstanding at any time exceed the Credit Limit; or (d) the Borrower shall fail
to comply with any of the financial covenants set forth in the Schedule or shall
fail to perform any other non-money Obligation which by its nature cannot be
cured; or (e) the Borrower shall fail to pay or perform any other non-monetary
Obligation which failure is not cured within 5 business days after the date due;
or (f) Any levy, assessment, attachment, seizure, lien or encumbrance is made on
all or any part of the Collateral which is not cured within 10 days after the
occurrence of the same; or (g) Dissolution, termination of existence, insolvency
or business failure of the Borrower; or appointment of a receiver, trustee or
custodian, for all or any part of the property of, assignment for the benefit of
creditors by, or the commencement of any proceeding by the Borrower under any
reorganization, bankruptcy, insolvency, arrangement, readjustment of debt,
dissolution or liquidation law or statute of any jurisdiction, now or in the
future in effect; or (h) the commencement of any proceeding against the Borrower
or any guarantor of any of the Obligations under any reorganization, bankruptcy
insolvency, arrangement, readjustment of debt, dissolution or liquidation law or
statute of any jurisdiction, now or in the future in effect, which is not cured
by the dismissal thereof within 30 days after the date commenced; (i) revocation
or termination of or limitation or denial of liability upon any guaranty of the
Obligations or any attempt to do any of the foregoing; or commencement of
proceedings by any guarantor of any of the Obligations under any bankruptcy or
insolvency law; or (j) revocation or termination of, or limitation or denial of
liability upon, any pledge of any certificate of deposit, securities or other
property or asset of any kind pledged by any third party to secure any or all of
the Obligations, or any attempt to do any of the foregoing; or commencement of
proceedings by or against any such third party under any bankruptcy or
insolvency law; or (k) the Borrower makes any payment on account of any
indebtedness or obligation which has been subordinated to the Obligations other
than as permitted in the applicable subordination agreement or if any person who
has subordinated such indebtedness or obligations terminates or in any way
limits his subordination agreement; or (l) there shall be a change in the record
or beneficial ownership of an aggregate of more than 20% of the outstanding
partnership interests of the Borrower, in one or more transactions, compared to
the ownership thereof in effect on the date hereof, without the prior written
consent of Silicon; or (m) a material adverse change occurs in the business,
operations, or financial or other condition of the Borrower, or a material
impairment occurs in the prospect of payment of the Obligations, or there is a
material impairment of the value or priority of Silicon's security interest in
the Collateral; or (n) the Borrower shall generally not pay its debts as they
become due; or the Borrower shall conceal, remove or transfer any part of its
property,

                                 PAGE 21 OF 35 PAGES

<PAGE>


with intent to hinder, delay or defraud its creditors, or make or suffer any
transfer of any of its property which may be fraudulent under any bankruptcy,
fraudulent conveyance or similar law.  Silicon may cease making any Loan
hereunder during any of the above cure periods, and thereafter if an Event of
Default has occurred.

         6.2  REMEDIES.  Upon the occurrence of any Event of Default, and at any
time thereafter, Silicon, at its option, and without notice or demand of any
kind (all of which are hereby expressly waived by the Borrower), may do any one
or more of the following: (a) Cease making Loans and cease extending letters of
credit or other credit facilities to or for the benefit of the Borrower under
this Agreement or any other document or agreement; (b) Accelerate and declare
all or any part of the Obligations to be immediately due, payable, and
performable, notwithstanding any deferred or installment payments allowed by any
instrument evidencing or relating to any Obligation; (c) Take possession of any
or all of the Collateral wherever it may be found, and for that purpose the
Borrower hereby authorizes Silicon without judicial process to enter onto any of
the Borrower's promises without interference to search for, take possession of,
keep, store, or remove any of the Collateral, and remain on the premises or
cause a Custodian to remain on the premises in exclusive control thereof without
charge for so long as Silicon deems it reasonably necessary in order to complete
the enforcement of its rights under this Agreement or any other agreement;
provided, however, that should Silicon seek to take possession of any or all of
the Collateral by Court process, the Borrower hereby irrevocably waives: (i) any
bond and any surety or security relating thereto required by any statute, court
rule or otherwise as an incident to such possession; (ii) any demand for
possession prior to the commencement of any suit or action to recover possession
thereof; and (iii) any requirement that Silicon retain possession of and not
dispose of any such Collateral until after trial or final judgment; (d) Require
the Borrower to assemble any or all of the Collateral and make it available to
Silicon at places designated by Silicon which are reasonably convenient to
Silicon and the Borrower, and to remove the Collateral to such locations as
Silicon may deem advisable; (e) Require Borrower to deliver to Silicon, in kind,
all checks and other payments received with respect to all accounts and general
intangibles, together with any necessary endorsements, within one day after the
date received by the Borrower; (f) Complete the processing, manufacturing or
repair of any Collateral prior to a disposition thereof and, for such purpose
and for the purpose of removal, Silicon shall have the right to use the
Borrower's premises, vehicles, hoists, lifts, cranes, equipment and all other
property without charge; (g) Sell, lease or otherwise dispose of any of the
Collateral in its condition at the time Silicon obtains possession of it or
after further manufacturing, processing or repair, at any one or more public
and/or private sales, in lots or in bulk, for cash, exchange or other property,
or on credit, and to adjourn any such sale from time to time without notice
other than oral announcement at the time scheduled for sale.  Silicon shall have
the right to conduct such disposition on the Borrower's premises without charge,
for such time or times as Silicon deems reasonable, or on Silicon's premises, or
elsewhere and the Collateral need not be located at the place of disposition.
Silicon may directly or through any affiliated company purchase or lease any
Collateral at any such public disposition, and if permissible under applicable
law, at any private disposition.  Any sale or other disposition of Collateral
shall not relieve the Borrower of any liability the Borrower may have if any
Collateral is defective as to title or physical condition or otherwise at the
time of sale; (h) Demand payment of, and collect any accounts and general
intangibles comprising Collateral and, in connection therewith, the Borrower
irrevocably authorizes Silicon to endorse or sign the Borrower's name on all
collections, receipts, instruments and other documents, to take possession of
and open mail addressed to the Borrower and remove therefrom payments made with
respect to any item of the Collateral or proceeds thereof, and, in Silicon's
sole discretion, to grant extensions of time to pay, compromise claims and
settle accounts and the like for less than face value; (i) Offset against any
sums in any of Borrower's general, special or other


                                 PAGE 22 OF 35 PAGES


<PAGE>

deposit accounts with Silicon; and (j) Demand and receive possession of any of
the Borrower's federal and state income tax returns and the books and records
utilized in the preparation thereof or referring thereto.  All reasonable
attorneys' fees, expenses, costs, liabilities and obligations incurred by
Silicon with respect to the foregoing shall be added to and become part of the
Obligations, shall be due on demand, and shall bear interest at a rate equal to
the highest interest rate applicable to any of the Obligations.  Without
limiting any of Silicon's rights and remedies, from and after the occurrence of
any Event of Default, the interest rate applicable to the Obligations shall be
increased by an additional five percent per annum.

    6.3  STANDARDS FOR DETERMINING COMMERCIAL REASONABLENESS.  The Borrower and
Silicon agree that a sale or other disposition (collectively, "sale") of any
Collateral which complies with the following standards will conclusively be
deemed to be commercially reasonable: (i) Notice of the sale is given to the
Borrower at least seven days prior to the sale, and, in the case of a public
sale, notice of the sale is published at least seven days before the sale in a
newspaper of general circulation in the county where the sale is to be
conducted; (ii) Notice of the sale describes the collateral in general,
non-specific terms; (iii) The sale is conducted at a place designated by
Silicon, with or without the Collateral being present; (iv) The sale commences
at any time between 8:00 a.m. and 6:00 p.m.; (v) Payment of the purchase price
in cash or by cashier's check or wire transfer is required; (vi) With respect to
any sale of any of the Collateral, Silicon may (but is not obligated to) direct
any prospective purchaser to ascertain directly from the Borrower any and all
information concerning the same.  Silicon may employ other methods of noticing
and selling the Collateral, in its discretion, if they are commercially
reasonable.

    6.4  POWER OF ATTORNEY.  Upon the occurrence of any Event of Default,
without limiting Silicon's other rights and remedies, the Borrower grants to
Silicon an irrevocable power of attorney coupled with an interest, authorizing
and permitting Silicon (acting through any of its employees, attorneys or
agents) at any time, at its option, but without obligation, with or without
notice to the Borrower, and at the Borrower's expense, to do any or all of the
following, in the Borrower's name or otherwise (a) Execute on behalf of the
Borrower any documents that Silicon may, in its sole and absolute discretion,
deem advisable in order to perfect and maintain Silicon's security interest in
the Collateral, or in order to exercise a right of the Borrower or Silicon, or
in order to fully consummate all the transactions contemplated under this
Agreement, and all other present and future agreements; (b) Execute on behalf of
the Borrower any document exercising, transferring or assigning any option to
purchase, sell or otherwise dispose of or to lease (as lessor or lessee) any
real or personal property which is part of Silicon's Collateral or in which
Silicon has an interest; (c) Execute on behalf of the Borrower, any invoices
relating to any account, any draft against any account debtor and any notice to
any account debtor, any proof of claim in bankruptcy, any Notice of Lien, claim
of mechanic's, materialman's or other lien, or assignment or satisfaction of
mechanic's, materialman's or other lien: (d) Take control in any manner of any
cash or non-cash items of payment or proceeds of Collateral; endorse the name of
the Borrower upon any instruments, or documents, evidence of payment or
Collateral that may come into Silicon's possession; (e) Endorse all checks and
other forms of remittances received by Silicon; (f) Pay, contest or settle any
lien, charge, encumbrance, security interest and adverse claim in or to any of
the Collateral, or any judgment based thereon, or otherwise take any action to
terminate or discharge the same; (g) Grant extensions of time to pay, compromise
claims and settle accounts and general intangibles for less than face value and
execute all releases and other documents in connection therewith; (h) Pay any
sums required on account of the Borrower's taxes or to secure the release of any
liens therefore or both; (i) Settle and adjust, and give releases of, any
insurance claim that relates to any of the Collateral and obtain payment
therefor; (j) Instruct any third party having custody or control of any


                                 PAGE 23 OF 35 PAGES


<PAGE>

books or records belonging to, or relating to, the Borrower to give Silicon the
same rights of access and other rights with respect thereto as Silicon has under
this Agreement; and (k) Take any action or pay any sum required of the Borrower
pursuant to this Agreement and any other present or future agreements.  Silicon
shall exercise the foregoing powers in a commercially reasonable manner.  Any
and all reasonable sums paid and any and all reasonable costs, expenses,
liabilities, obligations and attorneys' fees incurred by Silicon with respect to
the foregoing shall be added to and become part of the Obligations, shall be
payable on demand, and shall bear interest at a rate equal to the highest
interest rate applicable to any of the Obligations.  In no event shall Silicon's
rights under the foregoing power of attorney or any of Silicon's other rights
under this Agreement be deemed to indicate that Silicon is in control of the
business, management or properties of the Borrower.

    6.5  APPLICATION OF PROCEEDS.  All proceeds realized as the result of any
sale of the Collateral shall be applied by Silicon first to the costs, expenses,
liabilities, obligations and attorneys' fees incurred by Silicon in the exercise
of its rights under this Agreement, second to the interest due upon any of the
Obligations, and third to the principal of the Obligations, in such order as
Silicon shall determine in its sole discretion.  Any surplus shall be paid to
the Borrower or other persons legally entitled thereto; the Borrower shall
remain liable to Silicon for any deficiency.  If, Silicon, in its sole
discretion, directly or indirectly enters into a deferred payment or other
credit transaction with any purchaser at any sale or other disposition of
Collateral, Silicon shall have the option, exercisable at any time, in its sole
discretion, of either reducing the Obligations by the principal amount of
purchase price or deferring the reduction of the Obligations until the actual
receipt by Silicon of the cash therefore.

    6.6  REMEDIES CUMULATIVE.  In addition to the rights and remedies set forth
in this Agreement Silicon shall have all the other rights and remedies accorded
a secured party under the California Uniform Commercial Code and under all other
applicable laws, and under any other instrument or agreement now or in the
future entered into between Silicon and the Borrower, and all of such rights and
remedies are cumulative and none is exclusive.  Exercise or partial exercise by
Silicon of one or more of its rights Or remedies shall not be deemed an
election, nor bar Silicon from subsequent exercise or partial exercise of any
other rights or remedies.  The failure or delay of Silicon to exercise any
rights or remedies shall not operate as a waiver thereof, but all rights and
remedies shall continue in full force and effect until all of the Obligations
have been fully paid and performed.

7.  GENERAL PROVISIONS.

    7.1  CREDITING PAYMENTS.  Payments shall not be applied to the Obligations
until received by Silicon in immediately available federal funds, and any wire
transfer or other payment so received after 12:00 noon Pacific time shall be
deemed to have been received by Silicon as of the opening of business on the
next business day.

    7.2  NOTICES.  All notices to be given under this Agreement shall be in
writing and shall be given either personally or by regular first-class mail or
certified mail return receipt requested, addressed to Silicon or the Borrower at
the addresses shown in the heading to this Agreement, or at any other address
designated in writing by one party to the other party.  All notices shall be
deemed to have been given upon delivery in the case of notices personally
delivered to the Borrower or to Silicon, or at the expiration of two business
days following the deposit thereof in the United States Mail, with postage
prepaid.


                                 PAGE 24 OF 35 PAGES


<PAGE>

    7.3  SEVERABLE.  Should any provision of this Agreement be held by any
court of competent jurisdiction to be void or unenforceable, such defect shall
not affect the remainder of this Agreement, which shall continue in full force
and effect.

    7.4  INTEGRATION.  Agreement and such other written agreements, documents
and instruments as may be executed in connection herewith are the final, entire
and complete Agreement between the Borrower and Silicon and supersede all prior
and contemporaneous negotiations and oral representations and agreements, all of
which are merged and integrated in this Agreement.  THERE ARE NO ORAL
UNDERSTANDINGS, REPRESENTATIONS OR AGREEMENTS BETWEEN THE PARTIES WHICH ARE NOT
SET FORTH IN THIS AGREEMENT OR IN OTHER WRITTEN AGREEMENTS SIGNED BY THE PARTIES
IN CONNECTION HEREWITH.

    7.5  WAIVERS.  The failure of Silicon at any time or times to require the
Borrower to strictly comply with any of the provisions of this Agreement or any
other present or future agreement between the Borrower and Silicon shall not
waive or diminish any right of Silicon later to demand and receive strict
compliance therewith.  Any waiver of any default shall not waive or affect any
other default, whether poor or subsequent thereto.  None of the provisions of
this Agreement or any other agreement now or in the future executed by the
Borrower and delivered to Silicon shall be deemed to have been waived by any act
or knowledge of Silicon or its agents or employees, but only by a specific
written waiver signed by an officer of Silicon and delivered to the Borrower.
The Borrower waives demand, protest, notice of protest and notice of default or
dishonor, notice of payment and nonpayment, release, compromise, settlement,
extension or renewal of any commercial paper, instrument, account, general
intangible, document or guaranty at any time held by Silicon on which the
Borrower is or may in any way be liable, and notice of any action taken by
Silicon, unless expressly required by this Agreement.

    7.6  AMENDMENTS.  The terms and provisions of this Agreement may not be
waived or amended, except in a writing executed by the Borrower and a duly
authorized officer of Silicon.

    7.7  TIME OF ESSENCE.  Time is of the essence in the performance by the
Borrower of each and every obligation under this Agreement.

    7.8  ATTORNEYS FEES AND COSTS.  The Borrower shall reimburse Silicon for
all reasonable attorneys' fees and all filing, recording, search, title
insurance, appraisal, audit, and other reasonable costs incurred by Silicon,
pursuant to, or in connection with, or relating to this Agreement (whether or
not a lawsuit is filed), including, but not limited to, any reasonable
attorneys' fees and costs Silicon incurs in order to do the following:  prepare
and negotiate this Agreement and the documents relating to this Agreement;
obtain legal advice in connection with this Agreement; enforce, or seek to
enforce, any of its rights; prosecute actions against, or defend actions by,
account debtors; commence, intervene in, or defend any action or proceeding;
initiate any complaint to be relieved of the automatic stay in bankruptcy; file
or prosecute any probate claim, bankruptcy claim, third-party claim, or other
claim; examine, audit, copy, and inspect any of the Collateral or any of the
Borrower's books and records; protect, obtain possession of, lease, dispose of,
or otherwise enforce Silicon's security interest in, the Collateral; and
otherwise represent Silicon in any litigation relating to the Borrower.  IN
SATISFYING BORROWER'S OBLIGATION HEREUNDER TO REIMBURSE SILICON FOR ATTORNEYS
FEES, BORROWER MAY, FOR CONVENIENCE, ISSUE CHECKS DIRECTLY TO SILICON'S
ATTORNEYS, LEVY, SMALL & LALLAS, BUT BORROWER ACKNOWLEDGES AND AGREES THAT LEVY,
SMALL & LALLAS IS REPRESENTING ONLY SILICON AND NOT BORROWER IN CONNECTION WITH
THIS AGREEMENT.  If either Silicon or the Borrower files any lawsuit against the
other predicated on a breach of this Agreement, the prevailing party in such
action shall be entitled to recover its reasonable


                                 PAGE 25 OF 35 PAGES


<PAGE>

costs and attorneys' fees, including (but not limited to) reasonable attorneys'
fees and costs incurred in the enforcement of, execution upon or defense of any
order, decree, award or judgment.  All attorneys' fees and costs to which
Silicon may be entitled pursuant to this Paragraph shall immediately become part
of the Borrowers Obligations, shall be due on demand, and shall bear interest at
a rate equal to the highest interest rate applicable to any of Obligations.

    7.9  BENEFIT OF AGREEMENT.  The provisions of this Agreement shall be
binding upon and inure to the benefit of the respective successors, assigns,
heirs, beneficiaries and representatives of the parties hereto; provided,
however, that the Borrower may not assign or transfer any of its rights under
this Agreement without the prior written consent of Silicon, and any prohibited
alignment shall be void.  No consent by Silicon to any assignment shall release
the Borrower from its liability for the Obligations.

    7.10 JOINT AND SEVERAL LIABILITY.  If the Borrower consists of more than
one person, their liability shall be joint and several, and the compromise of
any claim with, or the release of, any Borrower shall not constitute a
compromise with, or a release of, any other Borrower.

    7.11 PARAGRAPH READINGS; CONSTITUTION.  Paragraph headings are only used in
this Agreement for convenience.  The Borrower acknowledges that the headings may
not describe completely the subject matter of the applicable paragraph, and the
headings shall not be used in any manner to construe, limit, define or interpret
any term or provision of this Agreement.  This Agreement has been fully reviewed
and negotiated between the parties and no uncertainty or ambiguity in any term
or provision of this Agreement shall be construed strictly against Silicon or
the Borrower under any rule of construction or otherwise.

    7.12 GOVERNING LAW; JURISDICTION; VENUE.  This Agreement and all acts and
transactions hereunder and all rights and obligations of Silicon and the
Borrower shall be governed by, and in accordance with, the laws of the State of
California.  Any undefined term used in this Agreement that is defined in the
California Uniform Commercial Code shall have the meaning assigned to that term
in the California Uniform Commercial Code.  As a material part of the
consideration to Silicon to enter into this Agreement, the Borrower (i) agrees
that all actions and proceedings relating directly or indirectly hereto shall,
at Silicon's option, be litigated in courts located within California, and that
the exclusive, venue therefor shall be San Diego County, (ii) consents to the
jurisdiction and venue of any such court and consents to service of process in
any such action or proceeding by personal delivery or any other method permitted
by law; and (iii) waives any and all rights the Borrower may have to object to
the jurisdiction of any such court, or to transfer or change the venue of any
such action or proceeding.

    7.13 MUTUAL WAIVER OF JURY TRIAL.  THE BORROWER AND SILICON EACH HEREBY
WAIVE THE RIGHT TO TRIAL BY JURY IN ANY ACTION OR PROCEEDING BASED UPON, ARISING
OUT OF, OR IN ANY WAY RELATING TO, THIS AGREEMENT OR ANY OTHER PRESENT OR FUTURE
INSTRUMENT OR AGREEMENT BETWEEN SILICON AND THE BORROWER, OR ANY CONDUCT, ACTS
OR OMISSIONS OF SILICON OR THE BORROWER OR ANY OF THEIR DIRECTORS, OFFICERS,
EMPLOYEES, AGENTS, ATTORNEYS OR ANY OTHER PERSONS AFFILIATED WITH SILICON OR THE
BORROWER.  THIS WAIVER OF THE RIGHT TO JURY TRIAL APPLIES TO ALL CONTRACT
CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, COMMON LAW CLAIMS, STATUTORY CLAIMS
AND ALL OTHER CLAIMS AND CAUSES OF ACTION OF EVERY KIND.  EACH PARTY RECOGNIZES
AND AGREES THAT THE FOREGOING JURY TRIAL WAIVER CONSTITUTES


                                 PAGE 26 OF 35 PAGES


<PAGE>

A MATERIAL INDUCEMENT TO THE OTHER PARTY TO ENTER INTO THIS AGREEMENT.  EACH
PARTY REPRESENTS AND WARRANTS THAT IT HAS REVIEWED THIS JURY TRIAL WAIVER WITH
ITS LEGAL COUNSEL AND THAT IT KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL
RIGHTS FOLLOWING ITS CONSULTATION WITH ITS LEGAL COUNSEL.

                                            Borrower:

                                            FORWARD VENTURES III, L.P., a
                                            Delaware limited partnership

                                            By:  Forward III Associates, LLC,
                                                 its general partner

                                            By /s/ Standish M. Fleming
                                               --------------------------------
                                                   Managing Member


                                            By /s/ Ivor Royston
                                               --------------------------------
                                                   Managing Member


                                            Silicon:

                                            SILICON VALLEY BANK

                                            By /s/ L. Bean
                                               --------------------------------
                                                   Senior Vice President


                                 PAGE 27 OF 35 PAGES

<PAGE>
SILICON VALLEY BANK


                                   SCHEDULE TO
                           LOAN AND SECURITY AGREEMENT


     BORROWER: FORWARD VENTURES III, L.P.

     ADDRESS:  10975 TORREYANA ROAD, SUITE 230 
               SAN DIEGO,, CALIFORNIA 92121

     DATE:          DECEMBER 19, 1996

     THIS SCHEDULE is an integral part of the Loan and Security Agreement
between Silicon Valley Bank ("Silicon") and the above-named borrower
("Borrower") of even date.

CREDIT LIMIT
(Section 1.1):           A single Loan in an amount not to exceed. $1,000,000,
                         which Loan will be made to the Borrower concurrently
                         herewith; such Loan is not a revolving Loan and
                         therefore repayments relating thereto shall not entitle
                         Borrower to reborrow any amounts so repaid.

INTEREST RATE 
(Section 1.2):           A rate equal to the "Prime Rate" in effect from time to
                         time per anum.  Interest shall be calculated on the
                         basis of a 360-day year for the actual number of days
                         elapsed.  "Prime Rate" means the rate announced from
                         time to time by Silicon as its "prime rate;" it is a
                         base rate upon which other rates charged by Silicon are
                         based, and it is not necessarily the best rate
                         available at Silicon.  The interest rate applicable to
                         the Obligations shall change on each date there is a
                         change in the Prime Rate.

LOAN ORIGINATION FEE
(Section 1.3):           $5,000. (Any Commitment Fee previously paid by the
                         Borrower in connection with this loan shall be credited
                         against this Fee.)

MATURITY DATE
(Section 5. 1):          The earlier of OCTOBER 15, 1997 or the Capital
                         Contribution Date (as defined below)

                         The term "Capital Contribution Date" means, on and
                         after September 1, 1997 only, the earlier of (A) five
                         (5) days after the Borrower has collected all amounts
                         owing to it pursuant to required capital contributions
                         under Section 3.2 and Section 3.4 of the Limited
                         Partnership Agreement of Borrower dated August 30, 1996
                         (the "Borrower Partnership Agreement") or (B) twenty
                         (20) days after Borrower has provided notice to its
                         partners instituting the first capital contribution


                         PAGE 28 OF 35 PAGES

<PAGE>

                         under Section 3.2 and Section 3.4 of the Borrower
                         Partnership Agreement.

SUBSIDIARIES OF BORROWER
(Section 3. 1):          NONE

PRIOR NAMES OF BORROWER
(Section 3.2)            NONE

PRESENT TRADE NAMES OF BORROWER
(Section 3.2):           NONE

PRIOR TRADE NAMES OF BORROWER
(Section 3.2):           NONE

OTHER LOCATIONS AND ADDRESSES
(Section 3.3):           NONE

MATERIAL ADVERSE LITIGATION
(Section 3. 1 0):        NONE

NEGATIVE COVENANTS-EXCEPTIONS
(Section 4.6):           NONE

FINANCIAL COVENANTS
(Section 4. 1):          NONE

     DEFINITIONS:        "Tangible net worth" means the excess of total assets
                         over total liabilities, determined in accordance with
                         generally accepted accounting principles, excluding
                         however all assets which would be classified as
                         intangible assets under generally accepted accounting
                         principles, including without limitation goodwill,
                         licenses, patents, trademarks, trade names, copyrights,
                         capitalized software and organizational costs, licenses
                         and franchises.

OTHER COVENANTS
(Section 4.1):           Borrower shall at all times comply with all of the
                         following additional covenants:

                         1.   BANKING RELATIONSHIP.  Borrower shall at all times
                         maintain a banking relationship with Silicon.

                         2.   PLEDGE AGREEMENT.  Borrower shall execute and
                         deliver a pledge agreement to Silicon, in Silicon's
                         standard form (the "Pledge Agreement"), relating to
                         233,663 shares of common stock of Triangle
                         Pharmaceuticals, Inc. (the "Shares") that Borrower will
                         acquire upon the dissolution of the Forward Ventures
                         Vanguard Fund, a California general partnership by
                         virtue of Borrower's interest therein.  Borrower hereby
                         authorizes Silicon to maintain possession of the Pledge
                         Agreement pending receipt of the Shares, Upon receipt
                         of the Shares, Borrower and Silicon agree that 

                         PAGE 29 OF 35 PAGES

<PAGE>

                         the Pledge Agreement shall be deemed immediately
                         effective at such time, without any further action or
                         notice whatsoever by Borrower.  At any time after the
                         date hereof, Borrower hereby agrees to take such
                         additional actions, and to execute such additional
                         documentation, in order to effectuate the purposes of
                         the Pledge Agreement, including, without limitation,
                         blank stock powers relating to the Shares.

                         3.   AGREEMENT REGARDING DISSOLUTION AND DELIVERY OF
                         SHARES.  Borrower shall cause Forward Ventures Vanguard
                         Fund, a California general partnership, to execute and
                         deliver to Silicon a letter agreement regarding: (A)
                         such partnership's agreement to dissolve on or before
                         December 20, 1996; and (B) in connection therewith, to
                         effect a distribution of such partnership's property to
                         its partners in a forthwith manner, PROVIDED that such
                         letter agreement shall also provide that Forward
                         Ventures Vanguard Fund, a California general
                         partnership, will forward the Shares directly to
                         Silicon in order to maintain possession thereof in
                         accordance with the Pledge Agreement.

                         4.   CAPITAL CONTRIBUTIONS; CERTIFICATE. Borrower
                         agrees to institute and collect Capital Contributions
                         under the Partnership Agreement, on and after September
                         1, 1997, in such amounts in order to repay the
                         Obligations in full.  In connection with the
                         institution of any and all capital contributions under
                         the Partnership Agreement, Borrower shall forward a
                         written certification thereof to Silicon within 10 days
                         of the institution thereof.

                         5.   AGREEMENT REGARDING INVESTMENTS.  Borrower hereby
                         agrees that it will not fund any additional investments
                         on and after September 1, 1997 unless and until the
                         Obligations are repaid in full.

                         6.   FEDERAL RESERVE FORM U. Borrower shall complete
                         Federal Reserve Form U prior to the making of the Loan
                         hereunder.

                         7.   AGREEMENT BY SILICON REGARDING CAPITAL
                         CONTRIBUTIONS.   Silicon hereby acknowledges and agrees
                         that it will not exercise any rights or remedies with
                         respect to the Capital Contributions before September
                         1, 1997, PROVIDED that the foregoing agreement shall
                         not affect the grant of the security interest by the
                         Borrower therein.

                         8.   ADDITIONAL REPRESENTATION BY BORROWER.  Borrower
                         hereby represents and warrants to Silicon that each of
                         the Borrower's partners has given no notice to
                         Borrower, and Borrower has no knowledge whatsoever, of
                         any dispute with Borrower or the 

                         PAGE 30 OF 35 PAGES

<PAGE>

                         occurrence of any other event or circumstance that
                         would affect the duty of any of the partners to satisfy
                         the partners' obligations relating to a capital
                         contribution call by the Borrower; and no partner of
                         Borrower has asserted any right of offset against any
                         capital contribution call.

                         9.   LEGAL OPINION.  A legal opinion of counsel to
                         Borrower shall be delivered to Silicon prior to the
                         making of the Loan hereunder, which shall be in form
                         and substance satisfactory to Silicon in its
                         discretion.

                                   BORROWER:

                                   FORWARD VENTURES III, L.P., A DELAWARE
                                   LIMITED PARTNERSHIP

                                   BY:  FORWARD III ASSOCIATES, LLC, ITS GENERAL
                                        PARTNER


                                   By /s/ Standish M. Fleming
                                      -----------------------------------
                                        Managing Member


                                   By /s/ Ivor Royston
                                      -----------------------------------
                                        Managing Member

                                   SILICON:

                                   SILICON VALLEY BANK


                                   By /s/ L. Bean
                                      -----------------------------------
                                        Senior Vice President


                               PAGE 31 OF 35 PAGES

<PAGE>

                                                                    Exhibit 7(e)

                                PLEDGE AGREEMENT


Pledgor:       Forward Ventures III, L.P.

Address:       10975 Torreyana Road, Suite 230
               San Diego, California 92121

Date:          December ___, 1996


     THIS PLEDGE AGREEMENT ("Pledge Agreement"), dated the above date, is
entered into at between SILICON VALLEY BANK ("Silicon"), whose address is 3003
Tasman Drive, Santa Clara, California 95054, and the pledgor named above
("Pledgor"), whose address is set forth above.

     1.   PLEDGE OF STOCK.  Pledgor shall concurrently deliver to Silicon the
stock certificates and other securities listed on Exhibit A hereto, together
with duly executed instruments of assignment thereof to Silicon (which, together
with all replacements and substitutions therefor are hereinafter referred to as
the "Securities").  Pledgor hereby pledges to Silicon and grants Silicon a
security interest in the Securities, and all rights and remedies relating to, or
arising out of, any and all of the foregoing, and all proceeds thereof
(collectively, the "Collateral") to secure the payment and performance of all
debts, duties, obligations, liabilities, representations, warranties and
guaranties of Pledgor to Silicon, heretofore, now, or hereafter made, incurred
or created, of every kind and nature (collectively, the "Obligations"),
including, but not limited to, those arising under the Loan and Security
Agreement of even date herewith (as amended from time to time, the "Loan
Agreement").  Any and all stock dividends, rights, warrants, options, puts,
calls, conversion rights and other securities and any and all property and money
distributed or delivered with respect to the Securities or issued upon the
exercise of any puts, calls, conversion rights, options, warrants or other
rights included in or pertaining to the Securities shall be included in the term
"Securities" as used herein and shall be subject to this Pledge Agreement, and
Pledgor shall deliver the same to Silicon immediately upon receipt thereof
together with any necessary instruments of transfer; provided, however, that
until an Event of Default (as hereinafter defined) shall occur, Pledgor may
retain any dividends paid in cash or its equivalent, with respect to any stock
included in the Securities and any interest paid with respect to any bonds,
debentures or other evidences of indebtedness included in the Securities. 
Pledgor hereby acknowledges that the acceptance of the pledge of the Securities
by Silicon shall not constitute a commitment of any kind by Silicon to permit
Pledgor to incur Obligations.

     2.   VOTING AND OTHER RIGHTS.  Pledgor shall have the right to exercise all
voting rights with respect to the Securities, provided no Event of Default (as
hereinafter defined) has occurred.  Upon the occurrence of any Event of Default,
Silicon shall have the right (but not any obligation) to exercise all voting
rights with respect to the Securities.  Provided no Event of Default has
occurred, Pledgor shall have the right to exercise all puts, calls, straddles,
conversion rights, options, warrants, and other rights and remedies with respect
to the Securities, provided Pledgor obtains the prior written consent of Silicon
thereto.  Silicon shall have no responsibility or liability whatsoever for the
exercise of, or failure to exercise, any puts, calls, straddles, conversion
rights, options, warrants, rights to vote or consent, or other rights with
respect to any of the Securities.  Upon the occurrence of any Event of Default,
Silicon shall have the right from time to 


                               PAGE 32 OF 35 PAGES

<PAGE>

time to transfer all or any part of the Securities to Silicon's own name or the
name of its nominee.

     3.   REPRESENTATIONS AND WARRANTIES.  Pledgor hereby represents and
warrants to Silicon that Pledgor now has, and throughout the term of this
Agreement will at all times have, good title to the Securities and the other
Collateral, free and clear of any and all security interests, liens and claims
of any kind whatsoever.

     4.   EVENTS OF DEFAULT.  If any one or more of the following events shall
occur, any such event shall constitute an Event of Default and Pledgor shall
provide Silicon with immediate notice thereof:  (a) Any warranty,
representation, statement, report or certificate made or delivered to Silicon by
Pledgor or any of the Pledgor's officers, employees or agents now or hereafter
is incorrect, false, untrue or misleading in any material respect; or (b) an
Event of Default shall occur under the Loan Agreement.

     5.   REMEDIES.  If an Event of Default shall occur, Pledgor shall give
immediate written notice thereof to Silicon.  Upon the occurrence of an Event of
Default, and at any time thereafter, Silicon shall have the right, without
notice to or demand upon Pledgor, to exercise any one or more of the following
remedies: (a) accelerate and declare all or any part of the Obligations to be
immediately due, payable and performable, notwithstanding any deferred or
installment payments allowed by any agreement or instrument evidencing or
relating to any of the same; (b) sell or otherwise dispose of the Securities,
and other Collateral, at a public or private sale for cash, or other property,
or on credit, with the authority to adjourn or postpone any such sale from time
to time without notice other than oral announcement at the time scheduled for
sale.  Silicon may directly or through any affiliate purchase the Securities,
and other Collateral, at any such public disposition, and if permissible under
applicable law, at any private disposition.  Pledgor and Silicon hereby agree
that it shall conclusively be deemed commercially reasonable for Silicon, in
connection with any sale or disposition of the Securities, to impose
restrictions and conditions as to the investment intent of a purchaser or
bidder, the ability of a purchaser or bidder to bear the economic risk of an
investment in the Securities, the knowledge and experience in business and
financial matters of a purchaser or bidder, the access of a purchaser or bidder
to information concerning the issuer of the Securities, as well as legend
conditions and stop transfer instructions restricting subsequent transfer of the
Securities, and any other restrictions or conditions which Silicon believes to
be necessary or advisable in order to comply with any state or federal
securities or other laws.  Pledgor acknowledges that the foregoing restrictions
may result in fewer proceeds being received upon such sale than would otherwise
be the case.  Pledgor hereby agrees to provide to Silicon any and all
information required by Silicon in connection with any sales of Securities by
Silicon hereunder.  If, after the occurrence of any Event of Default, Rule 144
promulgated by the Securities and Exchange Commission (or any other similar
rule) is available for use by Silicon in connection with the sales of any
Securities hereunder, Pledgor agrees not to utilize Rule 144 in the sale of any
securities held by Pledgor of the same class as the Securities, without the
prior written consent of Silicon.  Any and all attorneys' fees, expenses, costs,
liabilities and obligations incurred by Silicon in connection with the foregoing
shall be added to and become a part of the Obligations and shall be due from
Pledgor to Silicon upon demand.  

     6.   REMEDIES, CUMULATIVE; NO WAIVER.  The failure of Silicon to enforce
any of the provisions of this Agreement at any time or for any period of time
shall not be construed to be a waiver of any such provision or the right
thereafter to enforce the same.  All remedies hereunder shall be cumulative and
shall be in addition to all rights, powers and remedies given to Silicon by law.


                               PAGE 33 OF 35 PAGES

<PAGE>

     7.   TERM.  This Agreement and Silicon's rights hereunder shall continue in
full force and effect until all of the Obligations have been fully paid,
performed and discharged and the Loan Agreement and all other agreements between
Pledgor and Silicon have terminated.  Upon termination, Silicon shall return the
Collateral to Pledgor, with any necessary instruments of transfer.

     8.   REVIVOR.  If any payment made on any of the Obligations shall for any
reason be required to be returned by the Silicon, whether on the ground that
such payment constituted a preference or for any other reason, then for purposes
of this Agreement, and notwithstanding any prior termination of this Agreement,
such payment on the Obligations shall be treated as not having been made, and
this Agreement shall in all respects be effective with respect to the
Obligations as though such payment had not been made; and if the Collateral has
been released or returned to Pledgor, then Pledgor shall return the Collateral
to Silicon, to be held and dealt with in accordance with the terms of this
Agreement.

     9.   GENERAL PROVISIONS.  This Agreement and the documents referred to
herein are the entire and only agreements between Pledgor and Silicon with
respect to the subject matter hereof, and all representations, warranties,
agreements, or undertakings heretofore or contemporaneously made, with respect
to the subject matter hereof, which are not set forth herein or therein, are
superseded hereby.  The terms and provisions hereof may not be waived, altered,
modified, or amended except in a writing executed by Pledgor and Silicon.  All
rights, benefits and privileges hereunder shall inure to the benefit of and be
enforceable by Silicon and its successors and assigns and shall be binding upon
Pledgor and its successors and assigns; provided that Pledgor may not transfer
any of its rights hereunder without the prior written consent of Silicon. 
Paragraph headings are used herein for convenience only.  Pledgor acknowledges
that the same may not describe completely the subject matter of the applicable
paragraph, and the same shall not be used in any manner to construe, limit,
define or interpret any term or provision hereof.  Pledgor shall upon demand
reimburse Silicon for all costs, fees and expenses (including without limitation
attorneys' fees, whether or not suit be brought), which are incurred by Silicon
in connection with, or arising out of, this Agreement.  This Agreement and all
acts and transactions pursuant hereto and the rights and obligations of the
parties hereto shall be governed, construed, and interpreted in accordance with
the internal laws (and not conflict of laws rules) of the State of California. 
Pledgor hereby agrees that all actions or proceedings relating directly or
indirectly hereto may, at the option of Silicon, be litigated in courts located
within said State, and Pledgor hereby expressly consents to the jurisdiction of
any such court and consents to the service of process in any such action or
proceeding by personal delivery or by certified or registered mailing directed
to Pledgor at its last address known to Silicon.  


                               PAGE 34 OF 35 PAGES

<PAGE>

     10.  MUTUAL WAIVER OF RIGHT TO JURY TRIAL.  SILICON AND PLEDGOR EACH HEREBY
WAIVE THE RIGHT TO TRAIL BY JURY IN ANY ACTION OR PROCEEDING BASED UPON, ARISING
OUT OF, OR IN ANY WAY RELATING TO: (i) THIS AGREEMENT; OR (ii) ANY OTHER PRESENT
OR FUTURE INSTRUMENT OR AGREEMENT BETWEEN SILICON AND PLEDGOR; OR (iii) ANY
CONDUCT, ACTS OR OMISSIONS OF SILICON OR PLEDGOR OR ANY OF THEIR DIRECTORS,
OFFICERS, EMPLOYEES, AGENTS, ATTORNEYS OR ANY OTHER PERSONS AFFILIATED WITH
SILICON OR PLEDGOR; IN EACH OF THE FOREGOING CASES, WHETHER SOUNDING IN CONTRACT
OR TORT OR OTHERWISE. 

                                   PLEDGOR:

                                   FORWARD VENTURES III, L.P., a Delaware
                                   limited partnership

                                   By:  Forward III Associates, LLC, its general
                                        partner

                                   By /s/ Standish M. Fleming
                                      ---------------------------------------
                                        Managing Member

                                   By /s/ Ivor Royson
                                      ---------------------------------------
                                        Managing Member

                                   SILICON:

                                   SILICON VALLEY BANK


                                   By /s/ L. Bean
                                      --------------------------------------
                                        Senior Vice President


                                    EXHIBIT A


233,663 Shares of common stock Triangle Pharmaceuticals, Inc. represented by
Share Certificate No. ________________.


                               PAGE 35 OF 35 PAGES
 



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