TRIANGLE PHARMACEUTICALS INC
SC 13D, 1996-11-12
PHARMACEUTICAL PREPARATIONS
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           <PAGE>
                        SECURITIES AND EXCHANGE COMMISSION
                              Washington, D.C.  20549
           
           
                                   SCHEDULE 13D
           
           
                     Under the Securities Exchange Act of 1934
           
           
           
                           TRIANGLE PHARMACEUTICALS, INC.     
                    ------------------------------------------
                                 (Name of Issuer)
           
           
                                   Common Stock               
                     -----------------------------------------
                          (Title of Class of Securities)
           
           
                                    89589H 10 4               
                     -----------------------------------------
                                  (CUSIP NUMBER)
           
           
                               Linda E. Ransom, Esq.
                          Donovan Leisure Newton & Irvine
                               30 Rockefeller Plaza
                             New York, New York  10112
                                  (212) 632-3350                     
             --------------------------------------------------------
             (Name, Address and Telephone Number of Person Authorized
                      to Receive Notices and Communications)
           
           
                                 November 1, 1996                    
             --------------------------------------------------------
              (Date of Event which Requires Filing of this Statement)
           
           
           
           If the filing person has previously filed a statement on 
           Schedule 13G to report the acquisition which is the subject 
           of this Schedule 13D, and is filing this schedule because of 
           Rule 13d-1(b)(3) or (4), check the following box [ ].
           
           Check the following box if a fee is being paid with this 
           statement [  ].
<PAGE>





           <PAGE>
           CUSIP No. 89589H 10 4
                     -----------
           -----------------------------------------------------------------
           1.   Name of Reporting Person
                S.S. or I.R.S. Identification No. of Above Person
                
                George McFadden
                ###-##-####
           -----------------------------------------------------------------
           2.   Check the Appropriate Box if a Member of a Group (See 
                Instructions)
                
                (a) [ ]
                (b) [ ]
           -----------------------------------------------------------------
           3.   SEC Use Only
           
           -----------------------------------------------------------------
           4.   Source of Funds (See Instructions)
           
                OO
           -----------------------------------------------------------------
           5.   Check if Disclosure of Legal Proceedings is Required Pursuant 
                to Items 2(d) or 2(e)        
                                      -------
           -----------------------------------------------------------------
           6.   Citizenship or Place of Organization
                
                United States of America
           -----------------------------------------------------------------
           Number of         7.   Sole Voting Power
           Shares                 700,000                 
                                  ------------------------
           Beneficially      8.   Shared Voting Power
           Owned by               1,615,000               
                                  ------------------------
           Each Reporting    9.   Sole Dispositive Power
           Person With            700,000                 
                                  ------------------------
                             10.  Shared Dispositive Power
                                  1,615,000               
                                  ------------------------
           -----------------------------------------------------------------
           11.  Aggregate Amount Beneficially Owned by Each Reporting Person 
                
                2,315,000
           -----------------------------------------------------------------
           12.  Check if the Aggregate Amount in Row (11) Excludes Certain 
                Shares (See Instructions)        
                                          -------
           -----------------------------------------------------------------
<PAGE>





           13.  Percent of Class Represented by Amount in Row (11)
                
                13.4%
           -----------------------------------------------------------------
           14.  Type of Reporting Person (See Instructions)
                
                IN
           -----------------------------------------------------------------
           
<PAGE>





           <PAGE>
           
           Item 1.   Security and Issuer.
           ------    -------------------
           
                     This statement on Schedule 13D relates to shares of 

           the Common Stock, par value $0.001 per share (the "Common 

           Stock"), of Triangle Pharmaceuticals, Inc., a Delaware 

           corporation ("Triangle").  The address of Triangle's 

           principal executive offices is 4 University Place, 4611 

           University Drive, Durham, North Carolina 27707.

           
           Item 2.   Identity and Background.
           ------    -----------------------
           
                     This statement on Schedule 13D is filed on behalf 

           of George McFadden.  Mr. McFadden's principal occupation is 

           general partner of McFadden Brothers, the principal business 

           of which is investments.  Mr. McFadden's business address, 

           and the address of the principal office of McFadden Brothers, 

           is 745 Fifth Avenue, Suite 1400, New York, New York 10151.

                     During the last five years, Mr. McFadden has not 

           been convicted in a criminal proceeding (excluding traffic 

           violations or similar misdemeanors), or been a party to a 

           civil proceeding of a judicial or administrative body of 

           competent jurisdiction and as a result of such proceeding was 

           or is subject to a judgment, decree or final order enjoining 

           future violations of, or prohibiting or mandating activities 

           subject to, federal or state securities laws or finding any 

           violation with respect to such laws.  Mr. McFadden is a 

           citizen of the United States of America.
<PAGE>





           
           Item 3.   Source and Amount of Funds or Other Consideration.
           ------    -------------------------------------------------
           
                     The shares of the Common Stock of Triangle reported 

           herein as being directly held by Mr. McFadden were acquired 

           by him upon the automatic conversion of Series A and Series B 

           Preferred Stock of Triangle upon the initial public offering 

           of the Common Stock of Triangle on November 1, 1996 (the 

           "Initial Public Offering").

           
           Item 4.   Purpose of the Transaction.
           ------    --------------------------
           
                     The acquisition of shares of the Common Stock of 

           Triangle reported herein were made to acquire an equity 

           interest in Triangle as an investment.  Mr. McFadden is a 

           director of Triangle.  Therefore, he regularly consults with 

           the management of Triangle concerning the business and 

           affairs of Triangle and his equity interest therein.  Mr. 

           McFadden may from time to time, depending upon market 

           conditions, the state of affairs of Triangle and of the 

           businesses in which it is engaged and other factors, acquire 

           additional shares of the Common Stock of Triangle, subject to 

           applicable laws and to the availability of shares at prices 

           deemed favorable by Mr. McFadden.  Alternatively, Mr. 

           McFadden may dispose of shares of the Common Stock of 

           Triangle.  Mr. McFadden will continue to consider his equity 

           interest in Triangle and reserves the right to formulate such 

           plans or proposals, and to take such action, as may seem 

           appropriate in the circumstances existing at any future date.
<PAGE>





                     Except as set forth above, Mr. McFadden has no 

           present plans or intentions which would result in or relate 

           to any of the transactions described in subparagraphs (a) 

           through (j) of Item 4 of Schedule 13D.

           
           Item 5.   Interest in Securities of the Issuer.
           ------    ------------------------------------
           
                     (a)  As of November 10, 1996, Mr. McFadden 

           beneficially owned 2,315,000 shares of the Common Stock of 

           Triangle, or approximately 13.4% of the 17,235,238 

           outstanding shares of Common Stock of Triangle, as reported 

           in the prospectus dated October 31, 1996 of Triangle to be 

           outstanding (assuming no exercise of outstanding options and 

           warrants) after completion of the Initial Public Offering to 

           which such prospectus relates.  Other than the purchases of 

           shares of Common Stock of Triangle reported in Item 5(c) 

           hereof, all of the shares reported herein as being 

           beneficially owned by Mr. McFadden represent shares of Common 

           Stock of Triangle issued upon the automatic conversion of 

           Series A and Series B Preferred Stock of Triangle upon the 

           Initial Public Offering.

                     (b)  Mr. McFadden has the sole power to vote or to 

           direct the vote of, and sole power to dispose of or direct 

           the disposition of, 700,000 shares of the Common Stock of 

           Triangle; 400,000 of such shares are held by Mr. McFadden 

           directly, 200,000 of such shares are held by McFadden 

           Securities, L.P. and 100,000 of such shares are held by 
<PAGE>





           McFadden Brothers.  Mr. McFadden is general partner of each 

           of McFadden Securities, L.P. and McFadden Brothers.

                     Mr. McFadden shares the power to vote or direct the 

           vote of, or the power to dispose or direct the deposition of, 

           a further 1,615,000 shares of the Common Stock of Triangle, 

           as follows.  Mr. McFadden serves as co-trustee of a trust 

           under the will of Alexander B. McFadden, deceased, which 

           holds 600,000 shares, and as co-trustee of the Revised 

           Retirement Plan for Employees of Chemical Leaman Corporation 

           and Affiliated Corporations (the "Chemical Leaman Corporation 

           Retirement Plan"), which holds 100,000 shares.  Mr. 

           McFadden's wife, Carol O. McFadden, holds 85,000 shares 

           individually, 35,000 shares as trustee under a trust dated 

           March 4, 1983 for the benefit of Georgiana Elizabeth Moreton, 

           and 35,000 shares as trustee under a trust dated March 11, 

           1986 for the benefit of Piers Ivor P. Moreton.  Mr. McFadden 

           holds powers of attorney with respect to 425,000 shares held 

           by his brother John McFadden, 90,000 shares held by his 

           former wife Lesley Taylor, 75,000 shares held by his former 

           wife Lesley Taylor as custodian for Elizabeth Cutting 

           McFadden until age twenty-one under the New York Uniform 

           Gifts to Minors Act, and 170,000 shares held by David R. 

           Hamilton as trustee under a trust dated November 6, 1995 for 

           the benefit of Wilhelmina Josephine McFadden.  Information 

           with respect to the foregoing persons is set forth in 

           Appendix I hereto. 
<PAGE>





                     Mr. McFadden disclaims beneficial ownership of all 

           shares of Common Stock of Triangle reported herein other than 

           those which he owns directly and other than certain of the 

           shares held by McFadden Securities, L.P., McFadden Brothers 

           and the trust under the will of Alexander B. McFadden, 

           deceased, representing Mr. McFadden's individual interest in 

           such entities.

                     (c)  Within the last sixty days, Mr. McFadden 

           became the beneficial owner of the following shares of Common 

           Stock of Triangle, which were purchased for $10.00 per share 

           by the following persons in the Initial Public Offering on 

           November 1, 1996:

           
           McFadden Securities, L.P.                 200,000 shares
           
           Carol O. McFadden, trustee under
             trust dated March 4, 1983 for
             the benefit of Georgiana
             Elizabeth Moreton                        25,000 shares
           
           Carol O. McFadden, trustee under
             trust dated March 11, 1986 for
             the benefit of Piers Ivor
             P. Moreton                               25,000 shares
           
           George McFadden, Alexander
             Cushing and Mellon Bank
             Corporation, trustees
             of the trust under the
             will of Alexander B. 
             McFadden, deceased                       12,000 shares
           
           Carol O. McFadden                           5,000 shares
           
           John McFadden                              25,000 shares
           
           Chemical Leaman Corporation
             Retirement Plan                          20,000 shares
           
           
<PAGE>





           In addition, on November 1, 1996, the Chemical Leaman 

           Corporation Retirement Plan purchased 80,000 shares of the 

           Common Stock of Triangle at a purchase price per share of 

           $10.9375 per share in an ordinary brokerage transaction 

           effected on NASDAQ.

                     (d)  No person other than Mr. McFadden has the 

           right to receive or the power to direct the receipt of 

           dividends from, or the proceeds from the sale of, the shares 

           of Common Stock of Triangle disclosed in Item 5(a) hereof, 

           except as described in Item 5(b) hereof.

                     (e)  Not Applicable.

           
           Item 6.   Contracts, Arrangements, Understandings or
           ------    ------------------------------------------
                     Relationships with Respect to Securities of the
                     -----------------------------------------------
                     Issuer.
                     ------
           
                     There are no contracts, arrangements, under-

           standings or relationships (legal or otherwise) between 

           Mr. McFadden and any other person with respect to any of the 

           securities of Triangle, including, but not limited to, any 

           contract, arrangement, understanding or relationship relating 

           to the transfer or voting of any of such securities, finder's 

           fees, joint ventures, loan or option arrangements, puts or 

           calls, guarantees of profits, division of profits or loss, or 

           the giving or withholding of proxies.

           
           Item 7.   Material to be filed as Exhibits.
           ------    --------------------------------
           
                     Not Applicable.
<PAGE>





           <PAGE>
                                     SIGNATURE
           
           
                     After reasonable inquiry and to the best of my 

           knowledge and belief, I certify that the information set 

           forth in this statement is true, complete and correct.

           
           Dated:  November 12, 1996
           
           
           
           
                                         /s/  George McFadden   
                                         -----------------------
                                              George McFadden
           
<PAGE>





           <PAGE>
                                    APPENDIX I
           
           
                Set forth below is information with respect to the 
           persons with whom Mr. McFadden shares the power to vote or 
           direct the vote of, or the power to dispose of or direct the 
           deposition of, certain shares of the Common Stock of 
           Triangle.  All of the natural persons listed below are 
           citizens of the United States of America.  To the best 
           knowledge of Mr. McFadden, during the last five years none of 
           the persons listed below has been convicted in a criminal 
           proceeding (excluding traffic violations or similar 
           misdemeanors), or has been a party to a civil proceeding of a 
           judicial or administrative body of competent jurisdiction and 
           as a result of such proceeding was or is subject to a 
           judgment, decree or final order enjoining future violations 
           of, or prohibiting or mandating activities subject to, 
           federal or state securities laws or finding any violation 
           with respect to such laws. 
           
    <TABLE>
    
    <CAPTION>
    
    NAME         
    
    <S>                                   <C>
    Mellon Bank Corporation,              Organized in the Commonwealth
      co-trustee under the will of        of Pennsylvania
      Alexander B. McFadden,              1735 Market Street
      deceased                            Philadelphia, Pennsylvania 19101
                                          (Banking)
    
    Alexander Cushing,                    Chairman
      co-trustee under the will of        Squaw Valley Corp.
      Alexander B. McFadden,              1960 Squaw Valley Road
      deceased                            Olympic Valley, California 96146
                                          (Recreational facilities)
    
    David Boucher,                        Vice President and Chief 
      co-trustee of the                     Financial Officer
      Chemical Leaman Corporation         Chemical Leaman Corporation
      Retirement Plan                     102 Pickering Way 
                                          Exton, Pennsylvania  19341
                                          (Trucking)
    
    Gene Parkerson,                       Executive Vice President
      co-trustee of the                   Chemical Leaman Corporation
      Chemical Leaman Corporation         102 Pickering Way 
      Retirement Plan                     Exton, Pennsylvania  19341
                                          (Trucking)
    
<PAGE>





    Carol O. McFadden                     Homemaker
    
    John H. McFadden                      Partner
                                          McFadden, Pilkington & Ward
                                          City Tower
                                          40 Bafinghall Street
                                          London, England EC2V5DE
                                          (Law firm)
    
    Lesley Taylor                         Homemaker
    
    David R. Hamilton                     President and CEO
                                          Chemical Leaman Corporation
                                          102 Pickering Way 
                                          Exton, Pennsylvania  19341
                                          (Trucking)
    
    </TABLE>
    



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