TRIANGLE PHARMACEUTICALS INC
8-K, 1998-12-29
PHARMACEUTICAL PREPARATIONS
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<PAGE>



                          SECURITIES AND EXCHANGE COMMISSION

                               Washington, D.C.  20549


                                       FORM 8-K

                               Current Report Pursuant 
                            to Section 13 or 15(d) of the 
                           Securities Exchange Act of 1934


           Date of Report (Date of earliest event reported):  December 24, 1998


                            TRIANGLE PHARMACEUTICALS, INC.
                (Exact name of registrant as specified in its charter)


                                       DELAWARE
                    (State or other jurisdiction of incorporation)


                   000-21589                      56-1930728
           (Commission File Number)    (IRS Employer Identification No.)


 4 University Place, 4611 University Drive, Durham, North Carolina   27707
             (Address of principal executive offices)              (Zip Code)


                                    (919) 493-5980
                 (Registrant's telephone number, including area code)

<PAGE>

ITEM 5.  OTHER EVENTS.

     On December 24, 1998, Triangle Pharmaceuticals, Inc., a Delaware 
corporation (the "Company"), completed a private placement of 170,000 newly 
issued shares of Series A Preferred Stock (the "Shares") pursuant to certain 
Purchase Agreements, dated as of December 22, 1998 (the "Agreements").  The 
consideration received by the Company for the Shares was $17,000,000 in cash, 
or a price of $100.00 per share.  Net proceeds to the Company from the sale 
of the Shares were approximately $15,800,000.  Vector Securities 
International, Inc. acted as placement agent for the financing.

     Each Share will convert into ten shares of Common Stock of the Company 
upon the earlier of receipt of stockholder approval to be voted upon at the 
Annual Stockholders' Meeting for 1999 or December 24, 1999, the first 
anniversary of the closing of the sale.  The conversion ratio is subject to 
adjustment as provided in the Certificate of Designations, Preferences and 
Rights of the Series A Preferred Stock. The holders of the Shares remaining 
outstanding after June 15, 1999 shall receive a dividend of $5.00 per Share 
upon the conversion of the Shares into Common Stock.  This dividend will be 
payable, at the Company's option, in cash or Common Stock.  The Company has 
also agreed to file a resale registration statement with the Securities and 
Exchange Commission (the "SEC") relating to the sale of the Common Stock 
issuable upon conversion of the Shares within 30 days after the conversion 
date.

     The shares were offered and sold to selected accredited institutional 
investors (the "Purchasers") pursuant to a claim of exemption under 
Regulation D promulgated by the SEC or, alternatively, under Section 4(2) of 
the Securities Act of 1933, as amended (the "Act").  The Company did not use 
any general advertisement or solicitation in connection with the offer or 
sale of the Shares to the Purchasers.  Each Purchaser represented and 
warranted, among other things, that it was purchasing the Shares for 
investment only and not with a view to distribution and that it was an 
"accredited investor" (as defined in Regulation D).  Appropriate legends were 
affixed to the certificates for the Shares.  The Shares are restricted and 
may not be transferred or sold, except as permitted by the Agreements and 
pursuant to a registration of the Shares or an available exemption from 
registration.

<PAGE>


ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     (c)  EXHIBITS:

<TABLE>
<CAPTION>
          Exhibit
          Number           Description of Document
          -------          ------------------------
          <S>            <C>
            4.1          Certificate of Designations, Preferences and Rights 
                         of the Series A Preferred Stock, as filed with the 
                         Secretary of State of the State of Delaware.

           10.1          Form of Purchase Agreements with respect to the 
                         Series A Preferred Stock.

           99.1          Press Release, dated December 28, 1998.
</TABLE>

<PAGE>

                                     SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned hereunto duly authorized.

                              TRIANGLE PHARMACEUTICALS, INC.



                              By:  /s/ James A. Klein, Jr.
                                   ---------------------------------
                                   James A. Klein, Jr.
                                   Chief Financial Officer and Treasurer


Date:  December 28, 1998

<PAGE>

                                 INDEX TO EXHIBITS

<TABLE>
<CAPTION>

     Item
     ----
     <S>      <C>
      4.1     Certificate of Designations, Preferences and Rights of the 
              Series A Preferred Stock, as filed with the Secretary of State
              of the State of Delaware.

     10.1     Form of Purchase Agreements with respect to the Series A 
              Preferred Stock.

     99.1     Press Release, dated December 28, 1998.
</TABLE>


<PAGE>

Exhibit 4.1
- -----------


                CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS
                                          
                                       of the
                                          
                              SERIES A PREFERRED STOCK
                                          
                                         of
                                          
                           TRIANGLE PHARMACEUTICALS, INC.

                          (Pursuant to Section 151 of the
                         Delaware General Corporation Law)

                         __________________________________


          Triangle Pharmaceuticals, Inc., a corporation organized and 
existing under the General Corporation Law of the State of Delaware 
(hereinafter called the "Corporation"), hereby certifies that the following 
resolution was adopted by the Board of Directors of the Corporation as 
required by Section 151 of the General Corporation Law at a meeting duly held 
on December 16, 1998:

          "RESOLVED, that pursuant to the authority granted to and vested in 
the Board of Directors of the Corporation (hereinafter called the "Board of 
Directors" or the "Board") in accordance with the provisions of the 
Corporation's Second Restated Certificate of Incorporation, the Board of 
Directors hereby creates a series of the Preferred Stock, par value $0.001 
per share (the "Preferred Stock"), of the Corporation and hereby states the 
designation and number of shares, and fixes the relative rights, preferences, 
and limitations thereof as follows:

          Series A Preferred Stock:
          
          1.   DESIGNATION AND AMOUNT.  The shares of such series shall be 
designated as "Series A Preferred Stock" (the "Series A Preferred Stock") and 
the number of shares constituting the Series A Preferred Stock shall be One 
Hundred Seventy Thousand (170,000) shares.  Such number of shares may be 
increased or decreased by resolution of the Board of Directors.

          2.   DIVIDEND RIGHTS.  Subject to the rights of series of Preferred 
Stock which may from time to time come into existence, the holders 
("Holders") of Series A Preferred Stock that remain outstanding after June 
15, 1999, shall be entitled to receive, upon conversion of such shares or, if 
earlier, upon (i) the closing of a merger, consolidation or other transaction 
described in Section 3.e. below or (ii) the occurrence of a liquidation, 
dissolution or winding up described in Section 5 below, dividends at a rate 
of $5.00 per share of Series A Preferred Stock per annum.  Such dividends 
shall be non-cumulative and shall be payable, at the discretion of the 
Corporation, in cash or shares of the Corporation's Common Stock, par value 
$0.001 per share (the "Common Stock"). Any shares of Common Stock issued by 
the Corporation in payment of 

<PAGE>

the dividend will be valued based on the average closing bid price of the 
Common Stock on the market that the Board of Directors of the Corporation 
determines is the primary trading market for the Common Stock for the ten 
trading days ending three trading days prior to the date such dividend is 
paid.

          3.   CONVERSION.  

               a.   AUTOMATIC CONVERSION.  Each share of Series A Preferred 
Stock shall automatically convert into ten (10) shares of Common Stock of the 
Corporation (the "Conversion Rate") upon the earlier of (i) the date the 
stockholders of the Corporation (not including any votes cast by the Holders) 
first approve the terms of the issuance and sale of the Series A Preferred 
Stock or (ii) the first anniversary of the date upon which such share was 
issued.

               b.   ADJUSTMENTS TO CONVERSION RATE FOR STOCK DIVIDENDS, 
DISTRIBUTIONS, COMBINATIONS OR SUBDIVISIONS OF COMMON STOCK.  In the event 
that the Corporation, at any time after the date upon which any shares of 
Series A Preferred Stock were first issued, shall declare or pay, without 
consideration, any dividend or other distribution on the Common Stock payable 
in Common Stock or in any right to acquire Common Stock for no consideration, 
or shall effect a subdivision of the outstanding shares of Common Stock into 
a greater number of shares of Common Stock (by stock split, reclassification 
or otherwise than by payment of a dividend or other distribution in Common 
Stock or in any securities or rights to acquire Common Stock), or in the 
event the outstanding shares of Common Stock shall be combined or 
consolidated, by reclassification or otherwise, into a lesser number of 
shares of Common Stock, then the Conversion Rate for the Series A Preferred 
Stock in effect immediately prior to such event shall, concurrently with the 
effectiveness of such event, be proportionately decreased or increased, as 
appropriate.  In the event that the Corporation shall declare or pay, without 
consideration, any dividend or other distribution on the Common Stock payable 
in any right to acquire Common Stock for no consideration, then the 
Corporation shall be deemed to have made a dividend or other distribution 
payable in Common Stock in an amount of shares equal to the maximum number of 
shares issuable upon exercise of such rights to acquire Common Stock.

               c.   ADJUSTMENTS FOR RECLASSIFICATION AND REORGANIZATION.  If 
the Common Stock issuable upon conversion of the Series A Preferred Stock 
shall be changed into the same or a different number of shares of any other 
class or classes of stock, securities or assets, whether by capital 
reorganization, reclassification or otherwise (other than a subdivision or 
combination of shares provided for in subsection 3.b. above or a merger, 
consolidation or disposition of assets provided for in subsection 3.e. 
below), the Conversion Rate then in effect shall, concurrently with the 
effectiveness of such reorganization or reclassification, be proportionately 
adjusted so that the Series A Preferred Stock shall be convertible into, and 
provision shall be made to ensure that each of the Holders will thereafter 
have the right to acquire and receive, in lieu of the number of shares of 
Common Stock which the Holders would otherwise have been entitled to receive, 
a number of shares of such other class or classes of stock, securities or 
assets equivalent to the number of shares of Common Stock that would have 
been subject to receipt by the Holders upon conversion of the Series A 
Preferred Stock immediately before that change.

               d.   DIVIDENDS AND DISTRIBUTIONS.  In the event that the
Corporation, at any time after the date upon which any shares of Series A
Preferred Stock were first issued, shall pay 


                                       2
<PAGE>


any dividend or make any other distribution to holders of its Common Stock of 
any cash, evidence of indebtedness or other property (including any rights or 
warrants to purchase any securities of the Corporation) of any nature 
whatsoever (other than a dividend or other distribution provided for in 
subsection 3.b. above, a reclassification or reorganization provided for in 
subsection 3.c. above or a merger, consolidation or disposition of assets 
provided for in subsection 3.e. below), the Corporation shall at the same 
time pay or distribute to the Holders the cash, evidence of indebtedness or 
other property the Holders would have been entitled to receive if the shares 
of Series A Preferred Stock held by such Holders had been converted into 
Common Stock immediately prior to the record date for such dividend or 
distribution.

               e.   MERGER, CONSOLIDATION OR DISPOSITION OF ASSETS.  If the 
Corporation shall merge, consolidate or effect a share exchange with another 
entity, or shall sell, transfer or otherwise dispose of all or substantially 
all of its assets to another entity and pursuant to the terms of such merger, 
consolidation, share exchange or disposition of assets, cash, shares of 
common stock or other securities of the successor or acquiring entity, or 
property of any nature is to be received by or distributed to the holders of 
Common Stock of the Corporation, then the Holders shall be entitled to 
receive in respect of the Common Stock issuable upon conversion of this 
Series A Preferred Stock, the amount of cash, shares of common stock, other 
securities or other property that such Holders would have been entitled to 
receive if such Holders had converted this Series A Preferred Stock in full 
immediately prior to the occurrence of such merger, consolidation, share 
exchange or disposition of assets.  In the case of any such merger, 
consolidation, share exchange or disposition of assets, the successor or 
acquiring entity (and any affiliate thereof issuing securities) shall 
expressly assume the due and punctual observance and performance of each and 
every covenant and condition of this Series A Preferred Stock to be performed 
and observed by the Corporation and all of the obligations and liabilities 
hereunder, subject to such modifications as may be deemed appropriate (as 
determined by resolution of the Board and reasonably acceptable to the 
Holders of a majority of the outstanding shares of Series A Preferred Stock) 
in order to provide for adjustments of the Series A Preferred Stock issuable 
upon conversion of this Series A Preferred Stock that shall be as nearly 
equivalent as practicable to the adjustments provided for in this Section 3.  
The foregoing provisions shall similarly apply to successive mergers, 
consolidations, share exchanges and dispositions of assets.

               f.   OTHER ACTION AFFECTING COMMON STOCK.  If at any time or 
from time to time the Corporation shall take any action affecting its Common 
Stock, other than any action described in this Section 3, then, unless such 
action will not have an adverse effect upon the Holders' rights, the number 
of shares of Common Stock issuable upon conversion of this Series A Preferred 
Stock shall be adjusted in such manner and at such time as the Board shall in 
good faith determine (such determination to be reasonably acceptable to the 
Holders of a majority of the then outstanding shares of Series A Preferred 
Stock) to be equitable in the circumstances.  

               g.   NO FRACTIONAL SHARES.  No fractional shares shall be 
issued upon conversion of the Series A Preferred Stock, and the Corporation 
shall pay cash in an amount equal to the value of the fractional share of 
Common Stock to which any Holder would otherwise be entitled.  Whether or not 
fractional shares are issuable upon such conversion for any Holder shall be 
determined on the basis of the total number of shares of Series A Preferred 
Stock held by such Holder that are at the time being converted into Common 
Stock and the number of shares of Common Stock issuable upon such aggregate 
conversion.


                                       3
<PAGE>


               h.   NOTICE OF CERTAIN CORPORATE ACTION.  If the Corporation 
shall propose:

                    (i)   to pay any dividend to the holders of its Common 
Stock or to make any other distribution to the holders of its Common Stock;

                    (ii)  to offer to the holders of its Common Stock rights 
to subscribe for or to purchase any additional shares of Common Stock or any 
options or Securities convertible into or exercisable for Common Stock;

                    (iii) to effect any reorganization or reclassification of 
its Common Stock;

                    (iv)  to effect any consolidation, merger or share 
exchange or any sale, transfer or other disposition of all or substantially 
all of its assets; or

                    (v)   to effect the liquidation, dissolution or winding 
up of the Corporation, then, in each such case, the Corporation shall give to 
the Holders a notice of such proposed action, which shall specify the date on 
which such dividend, distribution or rights offer, reclassification, 
issuance, reorganization, consolidation, merger, share exchange, sale, 
transfer, disposition, liquidation, dissolution or winding up is to take 
place and the date of participation therein by the holders of Common Stock, 
if any such date is to be fixed, and shall also set forth such facts with 
respect thereto as shall be reasonably necessary to indicate the effect of 
such action on the Common Stock, and the number of shares of Common Stock 
that are issuable upon conversion of shares of Series A Preferred Stock after 
giving effect to any adjustment that will be required as a result of such 
action.  Such notice shall be so given no less than ten (10) calendar days 
prior to the date of the taking of such proposed action.  The Corporation 
shall also provide to the Holders copies of all materials it gives to the 
holders of Common Stock in connection with any solicitation of votes or 
consents at the same time it gives such materials pursuant to this subsection 
3.h. to the holders of Common Stock. Except as required by law, failure to 
give any such notice, or provide copies of such materials, or any defect 
therein, shall not affect the validity of the proceedings, actions or events 
taken in connection therewith, including but not limited to any of the 
actions described in clauses (i) through (v) hereof.

               i.   NO IMPAIRMENT.  The Corporation will not, by amendment of 
its Certificate of Incorporation or through any reorganization, transfer of 
assets, consolidation, merger, dissolution, issue or sale of securities or 
any other voluntary action, avoid or seek to avoid the observance or 
performance of any of the terms to be observed or performed hereunder by the 
Corporation, but will at all times in good faith assist in the carrying out 
of all the provisions of this Section 3 and in the taking of all such action 
as may be necessary or appropriate in order to protect the conversion rights 
of the Holders under this Section 3 against impairment.

          4.   COVENANTS.  The Corporation shall not, without the affirmative 
consent or approval of the Holders of the majority of the outstanding shares 
of Series A Preferred Stock:

               a.   in any manner authorize, issue or sell any shares of 
Series A Preferred Stock other than in connection with the transactions 
approved by the Board of Directors of the Corporation on December 16, 1998;

                                       4
<PAGE>

               b.   amend, repeal or modify any provision of this Certificate 
of Designations (including reclassifying, canceling or in any manner altering 
or changing the terms, designations, powers, preferences or relative, 
optional or other special rights, or qualifications, limitations or 
restrictions applicable thereto, of the Series A Preferred Stock); or

               c.   redeem any shares of Common Stock, unless (i) such offer 
to redeem such shares is also made to the Holders or (ii) such offer is to 
redeem shares of Common Stock issued to employees, consultants, officers or 
directors of the Corporation and for which the Corporation has a repurchase 
right upon cessation of service.

          5.   LIQUIDATION.  In the event of any liquidation, dissolution or 
winding up of this Corporation, either voluntary or involuntary, the Holders 
shall be entitled to receive, on an as-converted to Common Stock basis based 
on the Conversion Rate at the time in effect for the Series A Preferred Stock 
as set forth in Section 3 above, with the holders of Common Stock, a pro rata 
share of the assets of the Corporation legally available for distribution.

          6.   REDEMPTION.  The Holders shall have no right to demand that 
the Corporation redeem their shares of Series A Preferred Stock.

          7.   VOTING RIGHTS.  

               a.   Each holder of shares of Series A Preferred Stock shall 
be entitled to the right to the number of votes equal to the number obtained 
by dividing $100.00 by the closing bid price of the Common Stock on the 
Nasdaq National Market on the date on which the Series A Preferred Stock is 
issued, and shall be entitled to notice of any stockholders' meeting in 
accordance with the Bylaws of the Corporation.  Fractional votes shall not, 
however, be permitted and any fractional voting rights resulting from the 
above formula (after aggregating all shares into which shares of Series A 
Preferred Stock held by each holder could be converted) shall be rounded down 
to the nearest whole number.  

               b.   Except as otherwise provided herein or by law, the 
Holders and the holders of shares of Common Stock shall vote together as one 
class on all matters submitted to a vote of stockholders of the Corporation.

               c.    Except as required by law or this Certificate of 
Designations, Holders shall have no special voting rights and their consent 
shall not be required (except to the extent they are entitled to vote with 
holders of Common Stock as set forth herein) for taking any corporate action."

                                          
                  [Remainder Of This Page Intentionally Left Blank]


                                       5
<PAGE>


          IN WITNESS WHEREOF,  this Certificate of Designations, Preferences 
and Rights of the Series A Preferred Stock is executed on behalf of the 
Corporation by its Vice President, Business Development and Secretary this 
22nd day of December, 1998.
          

                              TRIANGLE PHARMACEUTICALS, INC.
          

                              By:  /s/ Chris A. Rallis
                                   -----------------------------------------
                                   Chris A. Rallis,
                                   Vice President, Business Development and 
                                   Secretary 

                                       6


<PAGE>

                                  PURCHASE AGREEMENT


     THIS AGREEMENT is made as of the __ day of December, 1998, by and between
Triangle Pharmaceuticals, Inc. (the "Company"), a corporation organized under
the laws of the State of Delaware, with its principal offices at 4 University
Place, 4611 University Drive, Durham, North Carolina 27707, and the purchaser
whose name and address is set forth on the signature page hereof (the
"Purchaser"). 

     IN CONSIDERATION of the mutual covenants contained in this Agreement, the
Company and the Purchaser agree as follows: 

     SECTION 1.  AUTHORIZATION OF SALE OF THE SHARES.  Subject to the terms and
conditions of this Agreement, the Company has authorized the sale of up to
170,000 shares (the "Shares") of the Series A Preferred Stock,  par value $0.001
per share (the "Preferred Stock"), of the Company.  Subject to adjustments
pursuant to the terms of the Certificate of Designations, Preferences and Rights
of the Preferred Stock (the "Certificate"), substantially in the form attached
hereto as Exhibit A, to be filed by the Company with the Secretary of State of
the State of Delaware on or prior to the Closing Date (as defined in Section 3),
each share of Preferred Stock shall be convertible into 10 shares (the
"Underlying Shares") of common stock, par value $0.001 per share, of the Company
(the "Common Stock") and shall possess such other rights and preferences as are
set forth in the Certificate. 

     SECTION 2.  AGREEMENT TO SELL AND PURCHASE THE SHARES.  At the Closing (as
defined in Section 3), the Company will sell to the Purchaser, and the Purchaser
will buy from the Company, upon the terms and conditions hereinafter set forth,
the number of Shares (at the purchase price) shown below: 


<TABLE>
<CAPTION>
                             Price Per
       Number to Be          Share In        Aggregate
        Purchased             Dollars           Price  
       ------------          ---------       ---------
       <S>                   <C>             <C> 

</TABLE>

     The Company proposes to enter into this same form of purchase agreement 
with certain other investors (the "Other Purchasers") and expects to complete 
sales of the Shares to them. The Purchaser and the Other Purchasers are 
hereinafter sometimes collectively referred to as the "Purchasers," and this 
Agreement and the agreements executed by the Other Purchasers are hereinafter 
sometimes collectively referred to as the "Agreements."  The term "Placement 
Agent" shall mean Vector Securities International, Inc.

     SECTION 3.  DELIVERY OF THE SHARES AT THE CLOSING.  The completion of the
purchase and sale of the Shares (the "Closing") shall occur as soon as
practicable and as agreed 


<PAGE>

by the parties hereto following receipt of evidence satisfactory to the 
Company and the Purchaser that the Certificate has been filed with and 
accepted by the Secretary of State of the State of Delaware, at a place and 
time (the "Closing Date") to be agreed upon by the Company, and the Placement 
Agent and of which the Purchasers will be notified by facsimile transmission 
or otherwise.

     At the Closing, the Company shall deliver to the Purchaser one or more 
stock certificates registered in the name of the Purchaser, or in such 
nominee name(s) as designated by the Purchaser in writing, representing the 
number of Shares set forth in Section 2 above.  The name(s) in which the 
stock certificates are to be registered are set forth in the Stock 
Certificate Questionnaire attached hereto as part of Appendix I.  The 
Company's obligation to complete the purchase and sale of the Shares and 
deliver such stock certificate(s) to the Purchaser at the Closing shall be 
subject to the following conditions, any one or more of which may be waived 
by the Company:  (a) receipt by the Company of same-day funds in the full 
amount of the purchase price for the Shares being purchased hereunder; (b) 
completion of the purchases and sales under the Agreements with all of the 
Other Purchasers; (c) the accuracy of the representations and warranties made 
by the Purchasers and the fulfillment of those undertakings of the Purchasers 
to be fulfilled prior to the Closing; and (d) receipt of evidence 
satisfactory to it that the Certificate has been filed with and accepted by 
the Secretary of State of the State of Delaware.  The Purchaser's obligation 
to accept delivery of such stock certificate(s) and to pay for the Shares 
evidenced thereby shall be subject to the following conditions: (a) the 
accuracy in all material respects of the representations and warranties made 
by the Company herein and the fulfillment in all material respects of those 
undertakings of the Company to be fulfilled prior to Closing; and (b) receipt 
of evidence satisfactory to it that the Certificate has been filed with and 
accepted by the Secretary of State of the State of Delaware.  The Purchaser's 
obligations hereunder are expressly not conditioned on the purchase by any or 
all of the Other Purchasers of the Shares that they have agreed to purchase 
from the Company.

     SECTION 4.  REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY. The
Company hereby represents and warrants to, and covenants with, the Purchaser as
follows: 

     4.1.  ORGANIZATION AND QUALIFICATION.  The Company and each of its
subsidiaries is a corporation duly organized, validly existing and in good
standing under the laws of its jurisdiction of incorporation and the Company and
each of its subsidiaries is qualified to do business as a foreign corporation in
each jurisdiction in which qualification is required, except where failure to so
qualify would not have a Material Adverse Effect (as defined herein) on the
Company.  

     4.2.  AUTHORIZED CAPITAL STOCK.  Except as disclosed in or contemplated by
the disclosure documents, as described in Section 4.19 hereof, distributed on
December 18, 1998 to potential purchasers of the Company's Preferred Stock (the
"Offering Materials"), the Company had, at September 30, 1998, (a) 24,071,255
shares of Common Stock outstanding (excluding, as of September 30, 1998, (i)
2,252,406 shares of Common Stock issuable upon the exercise of outstanding
options (at a weighted average price of $10.85 per share) under the Company's
1996 

                                      -2-

<PAGE>

Stock Incentive Plan, as amended (the "1996 Plan"); (ii) an aggregate of 
846,345 additional shares of Common Stock reserved for future option grants 
or stock issuances under the 1996 Plan and the Company's Employee Stock 
Purchase Plan; (iii) 46,000 shares of Common Stock issuable upon the exercise 
of outstanding warrants (at a weighted average exercise price of $2.23 per 
share); (iv) up to 2,100,000 shares of Common Stock issuable upon the 
achievement of certain developmental milestones relating to the Company's 
compounds; and (v) additional shares of Common Stock available for issuance 
in 1999, 2000 and 2001 as a result of automatic annual increases in the 
number of shares available for issuance under the 1996 Plan) and (b) no 
shares of preferred stock issued or outstanding.

     The issued and outstanding shares of the Company's Common Stock have 
been duly authorized and validly issued, are fully paid and nonassessable, 
have been issued in compliance with all federal and state securities laws, 
were not issued in violation of or subject to any preemptive rights or other 
rights to subscribe for or purchase securities, and conform in all material 
respects to the description thereof contained in the Offering Materials.  
Except as disclosed or contemplated by in the Offering Materials (including 
the issuance of options under the 1996 Plan and the issuance of shares of 
Common Stock pursuant to the Company's Employee Stock Purchase Plan after 
September 30, 1998), and the 4,800,000 shares of Common Stock the Company has 
agreed to issue and sell pursuant to Stock Purchase Agreements dated December 
10, 1998, the Company does not have outstanding any options to purchase, or 
any preemptive rights or other rights to subscribe for or to purchase, any 
securities or obligations convertible into, or any contracts or commitments 
to issue or sell, shares of its capital stock, any shares of capital stock of 
any subsidiary or any such options, rights, convertible securities or 
obligations.  The description of the Company's stock, stock bonus and other 
stock plans or arrangements and the options or other rights granted and 
exercised thereunder, set forth in the Offering Materials accurately and 
fairly presents the information required to be shown with respect to such 
plans, arrangements, options and rights.

     4.3.  ISSUANCE, SALE AND DELIVERY OF THE SHARES.  The  Shares have been 
duly authorized and, when issued, delivered and paid for in the manner set 
forth in this Agreement, will be duly authorized, validly issued, fully paid 
and nonassessable, and will be entitled to the rights and benefits described 
in the Certificate.  No preemptive rights or other rights to subscribe for or 
purchase exist with respect to the issuance and sale of the Shares by the 
Company pursuant to these Agreements or as a result of the issuance of the 
Underlying Shares upon the conversion of the Shares.  No stockholder of the 
Company has any right (which has not been waived or has not expired by reason 
of lapse of time following notification of the Company's intent to file a 
registration statement on behalf of the Purchasers pursuant to Section 7.1 
hereof (the "Registration Statement")) to require the Company to register the 
sale of any securities owned by such stockholder under the Securities Act of 
1933, as amended (the "Securities Act"), in the Registration Statement.  No 
further approval or authority of the stockholders or the Board of Directors 
of the Company will be required for the issuance and sale of the Shares to be 
sold by the Company as contemplated herein.  The Underlying Shares of Common 
Stock have been duly reserved for issuance upon the conversion of the Shares 
and the Underlying Shares, when issued and delivered in accordance with the 
terms of the Certificate, will be duly and validly issued, 

                                      -3-

<PAGE>

fully paid and nonassessable.

     4.4.  DUE EXECUTION, DELIVERY AND PERFORMANCE OF THE AGREEMENTS.  The 
Company has full legal right, corporate power and authority to enter into the 
Agreements and perform the transactions contemplated hereby.  The Agreements 
have been duly authorized, executed and delivered by the Company.  The making 
and performance of the Agreements by the Company and the consummation of the 
transactions herein contemplated will not violate any provision of the 
organizational documents of the Company or any of its subsidiaries and will 
not result in the creation of any lien, charge, security interest or 
encumbrance upon any assets of the Company pursuant to the terms or 
provisions of, or will not conflict with, result in the breach or violation 
of, or constitute, either by itself or upon notice or the passage of time or 
both, a default under any agreement, mortgage, deed of trust, lease, 
franchise, license, indenture, permit or other instrument to which the 
Company or any of its subsidiaries is a party or by which the Company or any 
of its subsidiaries or any of their respective properties may be bound or 
affected and in each case which would have, a material adverse effect on the 
condition (financial or otherwise), properties, business, prospects or 
results of operations of the Company and its subsidiaries, taken as a whole 
(a "Material Adverse Effect") or, to the Company's knowledge, any statute or 
any authorization, judgment, decree, order, rule or regulation of any court 
or any regulatory body, administrative agency or other governmental body 
applicable to the Company or any of its subsidiaries or any of their 
respective properties.  No consent, approval, authorization or other order of 
any court, regulatory body, administrative agency or other governmental body 
is required for the execution and delivery of this Agreement or the 
consummation of the transactions contemplated by this Agreement, except for 
compliance with the Blue Sky laws and federal securities laws applicable to 
the offering of the Shares and the filing of the Certificate with the 
Secretary of State of the State of Delaware.  Upon their execution and 
delivery, and assuming the valid execution thereof by the respective 
Purchasers, the Agreements will constitute valid and binding obligations of 
the Company, enforceable in accordance with their respective terms, except as 
enforceability may be limited by applicable bankruptcy, insolvency, 
reorganization, moratorium or similar laws affecting creditors' and 
contracting parties' rights generally and except as enforceability may be 
subject to general principles of equity (regardless of whether such 
enforceability is considered in a proceeding in equity or at law) and except 
as the indemnification agreements of the Company in Section 7.3 hereof may be 
legally unenforceable. 

     4.5.  ACCOUNTANTS. PricewaterhouseCoopers LLP, who have expressed their 
opinion with respect to the consolidated financial statements in the 
Company's Annual Report on Form 10-K for the year ended December 31, 1997, 
are independent accountants as required by the Securities Act and the rules 
and regulations promulgated thereunder (the "Rules and Regulations").

     4.6.  NO DEFAULTS.  Except as disclosed in the Offering Materials, and
except as to defaults, violations and breaches which individually or in the
aggregate would not be material to the Company and its subsidiary, taken as 
whole, neither the Company nor any of its subsidiaries is in violation or
default of any provision of its certificate of incorporation or bylaws, or other
organizational documents, or in breach of or default with respect to any
provision of any 

                                      -4-

<PAGE>

agreement, judgment, decree, order, mortgage, deed of trust, lease, 
franchise, license, indenture, permit or other instrument to which it is a 
party or by which it or any of its properties are bound; and there does not 
exist any state of fact which, with notice or lapse of time or both, would 
constitute an event of default on the part of the Company or any of its 
subsidiaries as defined in such documents, except such defaults which 
individually or in the aggregate would not be material to the Company and its 
subsidiary, taken as a whole.

     4.7.  CONTRACTS.  The contracts described in, or filed as exhibits to 
the Offering Materials, that are material to the Company and its 
subsidiaries, taken as a whole, are in full force and effect on the date 
hereof; and neither the Company nor any of its subsidiaries, nor, to the 
Company's knowledge, any other party is in breach of or default under any of 
such contracts which would have a Material Adverse Effect.

     4.8.  NO ACTIONS.  Except as disclosed in the Offering Materials, there 
are no legal or governmental actions, suits or proceedings pending or, to the 
Company's knowledge, threatened to which the Company or any of its 
subsidiaries is or may be a part or of which property owned or leased by the 
Company or any of its subsidiaries is or may be the subject, or related to 
environmental or discrimination matters, which actions, suits or proceedings, 
individually or in the aggregate, might prevent or might reasonably be 
expected to materially and adversely affect the transactions contemplated by 
this Agreement or result in a material adverse change in the condition 
(financial or otherwise), properties, business, prospects or results of 
operations of the Company and its subsidiaries, taken as a whole (a "Material 
Adverse Change"); and no labor disturbance by the employees of the Company or 
any of its subsidiaries exists, to the Company's knowledge, or is imminent 
which might reasonably be expected to have a Material Adverse Effect.  Except 
as disclosed in the Offering Materials, neither the Company nor any of its 
subsidiaries is party to or subject to the provisions of any material 
injunction, judgment, decree or order of any court, regulatory body, 
administrative agency or other governmental body.

     4.9.  PROPERTIES.  Each of the Company and its subsidiaries has good and 
marketable title to all the properties and assets reflected as owned by them 
in the consolidated financial statements included in the Offering Materials, 
subject to no lien, mortgage, pledge, charge or encumbrance of any kind 
except (i) those, if any, reflected in such consolidated financial 
statements, or (ii) those which are not material in amount and do not 
adversely affect the use made and promised to be made of such property by the 
Company or its subsidiaries. Each of the Company and its subsidiaries holds 
its leased properties under valid and binding leases, with such exceptions as 
are not materially significant in relation to their respective businesses.  
Except as disclosed in the Offering Materials, each of the Company and its 
subsidiaries owns or leases all such properties as are necessary to its 
operations as now conducted.

     4.10.  NO MATERIAL CHANGE.  Since September 30, 1998 and except as
described in or specifically contemplated by the Offering Materials, (i) neither
the Company nor its subsidiaries has incurred any material liabilities or
obligations, indirect or contingent, or entered into any material verbal or
written agreement or other transaction which is not in the ordinary 

                                      -5-

<PAGE>

course of business or which could reasonably be expected to result in a 
material reduction in the future earnings of the Company or its subsidiaries; 
(ii) neither the Company nor its subsidiaries has sustained any material loss 
or interference with its businesses or properties from fire, flood, 
windstorm, accident or other calamity not covered by insurance; (iii) neither 
the Company nor its subsidiaries has paid or declared any dividends or other 
distributions with respect to its capital stock and neither the Company nor 
its subsidiaries is in default in the payment of principal or interest on any 
outstanding debt obligations; (iv) there has not been any change in the 
capital stock of the Company other than (a) the sale of the Shares hereunder 
and shares or options issued pursuant to employee equity incentive plans or 
purchase plans approved by the Company's Board of Directors and (b) the 
Company's agreement to issue and sell 4,800,000 shares of Common Stock 
pursuant to the Stock Purchase agreements dated December 10, 1998; (v) there 
has not been any increase in indebtedness material to the Company (other than 
in the ordinary course of business); and (vi) except for the operating losses 
and negative cash flow the Company has continued to incur, there has not been 
a Material Adverse Change.

     4.11.  INTELLECTUAL PROPERTY.  Except as disclosed in or specifically 
contemplated by the Offering Materials, (i) the Company and its subsidiaries 
own or have obtained valid and enforceable licenses or options for the 
inventions, patent applications, patents, trademarks (both registered and 
unregistered), tradenames, copyrights and trade secrets necessary for the 
conduct of the Company's and its subsidiaries' respective businesses as 
currently conducted and as the Offering Materials indicate the Company and 
its subsidiaries contemplate conducting (collectively, the "Intellectual 
Property"); and (ii) to the Company's knowledge (for each of the following 
subsections (a) through (e)): (a) there are no third parties who have any 
ownership rights to any Intellectual Property that is owned by, or has been 
licensed to, the Company or its subsidiaries for the product indications 
described in the Offering Materials that would preclude the Company or its 
subsidiaries from conducting their respective businesses as currently 
conducted and as the Offering Materials indicate the Company and its 
subsidiaries contemplate conducting, except for the ownership rights of the 
owners of the Intellectual Property licensed or optioned by the Company or 
its subsidiaries; (b) there are currently no sales of any products that would 
constitute an infringement by third parties of any Intellectual Property 
owned, licensed or optioned by the Company or its subsidiaries; (c) there is 
no pending or threatened action, suit, proceeding or claim by others 
challenging the rights of the Company or its subsidiaries in or to any 
Intellectual Property owned, licensed or optioned by the Company or its 
subsidiaries, other than non-material claims; (d) there is no pending or 
threatened action, suit, proceeding or claim by others challenging the 
validity or scope of any Intellectual Property owned, licensed or optioned by 
the Company or its subsidiaries, other than non-material claims; and (e) 
there is no pending or threatened action, suit, proceeding or claim by others 
that the Company or its subsidiaries infringe or otherwise violate any 
patent, trademark, copyright, trade secret or other proprietary right of 
others, other than non-material claims.

     4.12.  COMPLIANCE.  Neither the Company nor any of its subsidiaries has
been advised, or has reason to believe, that it is not conducting business in
compliance with all applicable laws, rules and regulations of the jurisdictions
in which it is conducting business, including, without limitation, all
applicable local, state and federal environmental laws and 

                                      -6-

<PAGE>

regulations; except where failure to be so in compliance would not have a 
Material Adverse Effect.

     4.13.  TAXES.  Each of the Company and its subsidiaries has filed all 
necessary federal, state and foreign income and franchise tax returns and has 
paid or accrued all taxes shown as due thereon, and neither the Company nor 
its subsidiaries has knowledge of a tax deficiency which has been or might be 
asserted or threatened against it which could have a Material Adverse Effect.

     4.14.  TRANSFER TAXES.  On the Closing Date, all stock transfer or other 
taxes (other than income taxes) which are required to be paid in connection 
with the sale and transfer of the Shares to be sold to the Purchaser 
hereunder will be, or will have been, fully paid or provided for by the 
Company and all laws imposing such taxes will be or will have been fully 
complied with.

     4.15.  INVESTMENT COMPANY.  The Company is not an "investment company" 
or an "affiliated person" of, or "promoter" or "principal underwriter" for an 
investment company, within the meaning of the Investment Company Act of 1940, 
as amended.

     4.16.  OFFERING MATERIALS.  The Company has not distributed and will not 
distribute prior to the Closing Date any offering material related to the 
offering and sale of the Shares other than the term sheet, the Agreements and 
the Offering Materials or any amendment or supplement thereto.  The Company 
has not in the past nor will it hereafter take any action independent of the 
Placement Agent to sell, offer for sale or solicit offers to buy any 
securities of the Company which would bring the offer, issuance or sale of 
the Shares, as contemplated by this Agreement, within the provisions of 
Section 5 of the Securities Act, unless such offer, issuance or sale was or 
shall be within the exemptions of Section 4 of the Securities Act.

     4.17.  INSURANCE.  Each of the Company and its subsidiaries maintains 
insurance of the types and in the amounts that the Company reasonably 
believes is adequate for its business, including, but not limited to, 
insurance covering all real and personal property owned or leased by the 
Company or its subsidiaries against theft, damage, destruction, acts of 
vandalism and all other risks customarily insured against by similarly 
situated companies, all of which insurance is in full force and effect.

     4.18.  CONTRIBUTIONS.  Neither the Company at any time since its 
incorporation nor its subsidiaries at any time since they were acquired by 
the Company has, directly or indirectly, (i) made any unlawful contribution 
to any candidate for public office, or failed to disclose fully any 
contribution in violation of law, or (ii) made any payment to any federal or 
state governmental officer or official, or other person charged with similar 
public or quasi-public duties, other than payments required or permitted by 
the laws of the United States or any jurisdiction thereof.

     4.19.  OFFERING MATERIALS.   The Company represents and warrants that the
information contained in the following documents, which the Placement Agent has
furnished to 

                                      -7-

<PAGE>

the Purchaser, or will furnish prior to the Closing, is or will be true and 
correct in all material respects and does not omit a material fact necessary 
to make the statements therein not misleading as of their respective final 
dates: 

     (a)  the Company's Current Reports on Form 8-K filed with the Commission on
          September 11, 1997, November 12, 1997 and April 2, 1998; 

     (b)  the Company's Annual Report on Form 10-K for the fiscal year ended
          December 31, 1997 (without exhibits);  

     (c)  the Company's Quarterly Reports on Form 10-Q for the fiscal quarters
          ended March 31, 1998, June 30, 1998 and September 30, 1998; 

     (d)  the Company's Proxy Statement for the 1998 Annual Meeting of
          Stockholders; and

     (e)  a Summary of the Company's Business and Risks dated December 15, 1998.
     
     4.20.  LEGAL OPINION.  Prior to the Closing, Brobeck, Phleger & Harrison 
LLP, counsel to the Company, will deliver its legal opinion to the Placement 
Agent reasonably satisfactory to the Placement Agent and counsel to the 
Placement Agent.  Such opinion shall also state that each of the Purchasers 
may rely thereon as though it were addressed directly to such Purchaser.

     4.21.  INTELLECTUAL PROPERTY OPINION.  If requested by the Placement 
Agent, prior to the Closing, King & Spalding, patent counsel for the Company, 
will deliver its legal opinion to the Placement Agent reasonably satisfactory 
to the Placement Agent and counsel to the Placement Agent.  Such opinion 
shall state that each of the Purchasers may rely thereon as though it were 
addressed directly to such Purchaser.

     4.22.  CERTIFICATE.  At the Closing, the Company will deliver to 
Purchaser a certificate executed by the Chairman of the Board or President 
and the chief financial or accounting officer of the Company, dated the 
Closing Date, in form and substance reasonably satisfactory to the 
Purchasers, to the effect that the representations and warranties of the 
Company set forth in this Section 4 are true and correct in all material 
respects as of the date of this Agreement and as of the Closing Date, and the 
Company has complied with all the agreements and satisfied all the conditions 
herein on its part to be performed or satisfied on or prior to such Closing 
Date.

     4.23.  STOCKHOLDER APPROVAL.  The Company covenants and agrees that it will
(i) include in its proxy statement for its 1999 Annual Meeting of Stockholders a
proposal seeking stockholder approval of the terms of the issuance and sale of
the Shares pursuant to the Agreements and (ii) note in the proposal that the
Company's Board of Directors unanimously 

                                      -8-

<PAGE>

recommends that stockholders approve the terms of the issuance and sale of 
the Shares pursuant to the Agreements.

     SECTION 5.  REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PURCHASER. 
(a)  The Purchaser represents and warrants to, and covenants with, the Company
that:  (i) the Purchaser is knowledgeable, sophisticated and experienced in
making, and is qualified to make, decisions with respect to investments in
shares representing an investment decision like that involved in the purchase of
the Shares, including investments in securities issued by the Company, and has
requested, received, reviewed and considered all information it deems relevant
in making an informed decision to purchase the Shares; (ii) the Purchaser is
acquiring the number of Shares set forth in Section 2 above in the ordinary
course of its business and for its own account for investment (as defined for
purposes of the Hart-Scott-Rodino Antitrust Improvement Act of 1976 and the
regulations thereunder) only and with no present intention of distributing any
of such Shares (or the Underlying Shares) or any arrangement or understanding
with any other persons regarding the distribution of such Shares (or the
Underlying Shares); (iii) the Purchaser will not, directly or indirectly, offer,
sell, pledge, transfer or otherwise dispose of (or solicit any offers to buy,
purchase or otherwise acquire or take a pledge of) any of the Shares or
Underlying Shares except in compliance with the Securities Act and the Rules and
Regulations; (iv) the Purchaser has completed or caused to be completed the
Stock Certificate Questionnaire, attached hereto as Appendix I, and the answers
thereto are true and correct as of the date hereof; (v) the Purchaser will
complete and deliver, or cause to be completed and delivered, to the Company
within 10 days after the date the Shares are converted into Underlying Shares,
the Registration Statement Questionnaire, attached hereto as Appendix I, for use
in preparation of the Registration Statement, and the answers thereto will be
true and correct as of the date of the Questionnaire is delivered to the Company
and as of the effective date of the Registration Statement; (vi) the Purchaser
has, in connection with its decision to purchase the number of Shares set forth
in Section 2 above, (a) relied solely upon the Offering Materials and the
representations and warranties of the Company contained herein and (b) had a
reasonable opportunity to ask questions of, and receive answers from, the
Company concerning the Company and the offering of the Shares; (vii) the
Purchaser acknowledges that the price and terms of the Preferred Stock offered
hereby have been determined by negotiation based in part on the market price for
the Common Stock, and that it does not necessarily bear any relationship to the
assets, book value or potential performance of the Company or any other
recognized criteria of value; and (viii) the Purchaser is an "accredited
investor" within the meaning of Rule 501 of Regulation D promulgated under the
Securities Act.

     (b)  The Purchaser hereby covenants with the Company not to (1) make any
sale of the Shares except in compliance with the Securities Act and the Rules
and Regulations, and the Purchaser acknowledges and agrees that the Shares are
not transferable on the books of the Company unless the certificate submitted to
the transfer agent evidencing the Shares is accompanied by an opinion of
counsel, satisfactory in form and substance to the Company, to the effect that
the Shares have been sold in compliance with the Securities Act and the Rules
and Regulations and any applicable state securities or Blue Sky laws, and (2)
make any sale of the Underlying Shares without satisfying the prospectus
delivery requirement under the Securities 

                                      -9-

<PAGE>

Act, and the Purchaser acknowledges and agrees that the Underlying Shares are 
not transferable on the books of the Company unless the certificate submitted 
to the transfer agent evidencing the Underlying Shares is accompanied by a 
separate officer's certificate:  (i) in the form of Appendix II hereto, (ii) 
executed by an officer of, or other authorized person designated by, the 
Purchaser and (iii) to the effect that (A) the Underlying Shares have been 
sold in accordance with the Registration Statement, the Securities Act and 
the Rules and Regulations and any applicable state securities or Blue Sky 
laws and (B) the requirement of delivering a current prospectus has been 
satisfied.  The Purchaser acknowledges that there may occasionally be times 
when the Company must suspend the use of the prospectus forming a part of the 
Registration Statement until such time as an amendment to the Registration 
Statement has been filed by the Company and declared effective by the 
Commission, or until such time as the Company has filed an appropriate report 
with the Commission pursuant to the Exchange Act. The Purchaser hereby 
covenants that it will not sell any Underlying Shares pursuant to said 
prospectus during the period commencing at the time at which the Company 
gives the Purchaser written notice of the suspension of the use of said 
prospectus and ending at the time the Company gives the Purchaser written 
notice that the Purchaser may thereafter effect sales pursuant to said 
prospectus.  The Purchaser further covenants to notify the Company promptly 
of the sale of all of its Underlying Shares. 

     (c)  The Purchaser further represents and warrants to, and covenants 
with, the Company that (i) the Purchaser has full right, power, authority and 
capacity to enter into this Agreement and to consummate the transactions 
contemplated hereby and has taken all necessary action to authorize the 
execution, delivery and performance of this Agreement, and (ii) upon the 
execution and delivery of this Agreement, this Agreement shall constitute a 
valid and binding obligation of the Purchaser enforceable in accordance with 
its terms, except as enforceability may be limited by applicable bankruptcy, 
insolvency, reorganization, moratorium or similar laws affecting creditors' 
and contracting parties' rights generally and except as enforceability may be 
subject to general principles of equity (regardless of whether such 
enforceability is considered in a proceeding in equity or at law) and except 
as the indemnification agreements of the Purchaser in Section 7.3 hereof may 
be legally unenforceable. 

     SECTION 6.  SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS. 
Notwithstanding any investigation made by any party to this Agreement or by the
Placement Agent, all covenants, agreements, representations and warranties made
by the Company and the Purchaser herein and in the certificates for the Shares
delivered pursuant hereto shall survive the execution of this Agreement, the
delivery to the Purchaser of the Shares being purchased and the payment
therefor. 

                                      -10-

<PAGE>

     SECTION 7.  REGISTRATION OF THE SHARES; COMPLIANCE WITH THE SECURITIES ACT.

     7.1.  REGISTRATION PROCEDURES AND EXPENSES.  The Company shall, 
following the conversion of the Shares into Common Stock, which shall occur 
upon the earlier of either (i) receipt of approval by the Company's 
stockholders of the terms of the issuance and sale of the Shares, upon such 
approval the Shares shall be converted into shares of Common Stock or (ii) 
the one-year anniversary of the Closing Date, upon which the Shares shall 
automatically be converted into shares of Common Stock (the earlier to occur 
of such dates, the "Conversion Date"): 

     (a)  as soon as practicable, but in no event later than 30 days following
          the Conversion Date, file with the Commission the Registration
          Statement on Form S-3 relating to the sale of the Underlying Shares by
          the Purchaser from time to time through the automated quotation system
          of the Nasdaq National Market or the facilities of any national
          securities exchange on which the Common Stock is then traded or in
          privately-negotiated transactions; 

     (b)  use its reasonable efforts, subject to receipt of necessary
          information from the Purchasers, to cause the Commission to notify the
          Company of the Commission's willingness to declare the Registration
          Statement effective within 60 days after the Registration Statement is
          filed by the Company; 

     (c)  prepare and file with the Commission such amendments and supplements
          to the Registration Statement and the prospectus used in connection
          therewith as may be necessary to keep the Registration Statement
          effective until the earlier of (i) twenty-four months after the
          Closing Date or (ii) the date on which the Underlying Shares may be
          resold by the Purchasers without registration by reason of Rule 144(k)
          under the Securities Act or any other rule of similar effect;
 
     (d)  furnish to the Purchaser with respect to the Underlying Shares
          registered under the Registration Statement (and to each underwriter,
          if any, of such Underlying Shares) such reasonable number of copies of
          prospectuses and such other documents as the Purchaser may reasonably
          request, in order to facilitate the public sale or other disposition
          of all or any of the Underlying Shares by the Purchaser; PROVIDED,
          HOWEVER, that the obligation of the Company to deliver copies of
          prospectuses to the Purchaser shall be subject to the receipt by the
          Company of reasonable assurances from the Purchaser that the Purchaser
          will comply with the applicable provisions of the Securities Act and
          of such other securities or blue sky laws as may be applicable in
          connection with any use of such prospectuses; 

     (e)  file documents required of the Company for normal Blue Sky clearance
          in 

                                      -11-

<PAGE>

          states specified in writing by the Purchaser; PROVIDED, HOWEVER,
          that the Company shall not be required to qualify to do business or
          consent to service of process in any jurisdiction in which it is not
          now so qualified or has not so consented; and 

     (f)  bear all expenses in connection with the procedures in paragraphs (a)
          through (e) of this Section 7.1 and the registration of the Underlying
          Shares pursuant to the Registration Statement, other than fees and
          expenses, if any, of counsel or other advisers to the Purchaser or the
          Other Purchasers or underwriting discounts, brokerage fees and
          commissions incurred by the Purchaser or the Other Purchasers, if any.
 
     7.2.  TRANSFER OF UNDERLYING SHARES AFTER REGISTRATION.  The Purchaser 
agrees that it will not effect any disposition of the Underlying Shares or 
its right to purchase the Underlying Shares that would constitute a sale 
within the meaning of the Securities Act, except as contemplated in the 
Registration Statement referred to in Section 7.1, and that it will promptly 
notify the Company of any changes in the information set forth in the 
Registration Statement regarding the Purchaser or its Plan of Distribution. 

     7.3.  INDEMNIFICATION.  For the purpose of this Section 7.3: 

     (i)  the term "Purchaser/Affiliate" shall include the Purchaser and any
          affiliate of such Purchaser; and

     (ii) the term "Registration Statement" shall include any final prospectus,
          exhibit, supplement or amendment included in or relating to the
          Registration Statement referred to in Section 7.1. 

     (a)  The Company agrees to indemnify and hold harmless each of the 
Purchasers and each person, if any, who controls any Purchaser within the 
meaning of the Securities Act, against any losses, claims, damages, 
liabilities or expenses, joint or several, to which such Purchasers or such 
controlling person may become subject, under the Securities Act, the Exchange 
Act, or any other federal or state statutory law or regulation, or at common 
law or otherwise (including in settlement of any litigation, if such 
settlement is effected with the written consent of the Company), insofar as 
such losses, claims, damages, liabilities or expenses (or actions in respect 
thereof as contemplated below) arise out of or are based upon any untrue 
statement or alleged untrue statement of any material fact contained in the 
Registration Statement, including the prospectus, financial statements and 
schedules, and all other documents filed as a part thereof, as amended at the 
time of effectiveness of the Registration Statement, including any 
information deemed to be a part thereof as of the time of effectiveness 
pursuant to paragraph (b) of Rule 430A, or pursuant to Rule 434, of the Rules 
and Regulations, or the prospectus, in the form first filed with the 
Commission pursuant to Rule 424(b) of the Regulations, or filed as part of 
the Registration Statement at the time of effectiveness if no Rule 424(b) 
filing is required (the "Prospectus"), or any amendment or supplement 
thereto, or arise out 

                                      -12-

<PAGE>

of or are based upon the omission or alleged omission to state in any of them 
a material fact required to be stated therein or necessary to make the 
statements in any of them, in light of the circumstances under which they 
were made, not misleading, or arise out of or are based in whole or in part 
on any inaccuracy in the representations and warranties of the Company 
contained in this Agreement, or any failure of the Company to perform its 
obligations hereunder or under law, and will reimburse each Purchaser and 
each such controlling person for any legal ad other expenses as such expenses 
are reasonably incurred by such Purchaser or such controlling person in 
connection with investigating, defending, settling, compromising or paying 
any such loss, claim, damage, liability, expense or action; PROVIDED, 
HOWEVER, that the Company will not be liable in any such case to the extent 
that any such loss, claim, damage, liability or expense arises out of or is 
based upon (i) an untrue statement or alleged untrue statement or omission or 
alleged omission made in the Registration Statement, the Prospectus or any 
amendment or supplement thereto in reliance upon and in conformity with 
written information furnished to the Company: by or on behalf of the 
Purchaser expressly for use therein, or (ii) the failure of such Purchaser to 
comply with the covenants and agreements contained in Sections 5(b) or 7.2 
hereof respecting sale of the Underlying Shares, or (iii) the inaccuracy of 
any representations made by such Purchaser herein or (iv) any statement or 
omission in any Prospectus that is corrected in any subsequent Prospectus 
that was delivered to the Purchaser prior to the pertinent sale or sales by 
the Purchaser.

     (b)  Each Purchaser will severally indemnify and hold harmless the 
Company, each of its directors, each of its officers who signed the 
Registration Statement and each person, if any, who controls the Company 
within the meaning of the Securities Act, against any losses, claims, 
damages, liabilities or expenses to which the Company, each of its directors, 
each of its officers who signed the Registration Statement or controlling 
person may become subject, under the Securities Act, the Exchange Act, or any 
other federal or state statutory law or regulation, or at common law or 
otherwise (including in settlement of any litigation, if such settlement is 
effected with the written consent of such Purchaser) insofar as such losses, 
claims, damages, liabilities or expenses (or actions in respect thereof as 
contemplated below) arise out of or are based upon (i) any failure to comply 
with the covenants and agreements contained in Sections 5(b) or 7.2 hereof 
respecting the sale of the Underlying Shares or (ii) the inaccuracy of any 
representation made by such Purchaser herein or (iii) any untrue or alleged 
untrue statement of any material fact contained in the Registration 
Statement, the Prospectus, or any amendment or supplement thereto, or arise 
out of or are based upon the omission or alleged omission to state therein a 
material fact required to be stated therein or necessary to make the 
statements therein not misleading, in each case to the extent, but only to 
the extent, that such untrue statement or alleged untrue statement or 
omission or alleged omission was made in the Registration Statement, the 
Prospectus, or any amendment or supplement thereto, in reliance upon and in 
conformity with written information furnished to the Company by or on behalf 
of any Purchaser expressly for use therein, and will reimburse the Company, 
each of its directors, each of its officers who signed the Registration 
Statement or controlling person for any legal and other expense reasonably 
incurred by the Company, each of its directors, each of it officers who 
signed the Registration Statement or controlling person in connection with 
investigating, defending, settling, compromising or paying any such loss, 
claim, damage, liability, expense or 

                                      -13-

<PAGE>

action. 

     (c)  Promptly after receipt by an indemnified party under this Section 
7.3 of notice of the threat or commencement of any action, such indemnified 
party will, if a claim in respect thereof is to be made against an 
indemnifying party under this Section 7.3 promptly notify the indemnifying 
party in writing thereof; but the omission so to notify the indemnifying 
party will not relieve it from any liability which it may have to any 
indemnified party for contribution or otherwise than under the indemnity 
agreement contained in this Section 7.3 or to the extent it is not prejudiced 
as a result of such failure. In case any such action is brought against any 
indemnified party and such indemnified party seeks or intends to seek 
indemnity from an indemnifying party, the indemnifying party will be entitled 
to participate in, and, to the extent that it may wish, jointly with all 
other indemnifying parties similarly notified, to assume the defense thereof 
with counsel reasonably satisfactory to such indemnified party; provided, 
however, if the defendants in any such action include both the indemnified 
party and the indemnifying party and the indemnified party shall have 
reasonably concluded that there may be a conflict between the positions of 
the indemnifying party and the indemnified party in conducting the defense of 
any such action or that there may be legal defenses available to it and/or 
other indemnified parties which are different from or additional to those 
available to the indemnifying party, the indemnified party or parties shall 
have the right to select separate counsel to assume such legal defenses and 
to otherwise participate in the defense of such action on behalf of such 
indemnified party or parties.  Upon receipt of notice from the indemnifying 
party to such indemnified party of its election so to assume the defense of 
such action and approval by the indemnified party of counsel, the 
indemnifying party will not be liable to such indemnified party under this 
Section 7.3 for any legal or other expenses subsequentlyincurred by such 
indemnified party in connection with the defense thereof unless (i) the 
indemnified party shall have employed such counsel in connection with the 
assumption of legal defenses in accordance with the proviso to the preceding 
sentence (it being understood, however, that the indemnifying party shall not 
be liable for the expenses of more than one separate counsel, approved by 
such indemnifying party in the case of paragraph (a), representing the 
indemnified parties who are parties to such action) or (ii) the indemnified 
party shall not have employed counsel reasonably satisfactory to the 
indemnified party to represent the indemnified party within a reasonable time 
after notice of commencement of action, in each of which cases the reasonable 
fees and expenses of counsel shall be at the expense of the indemnifying 
party.

     (d)  If the indemnification provided for in this Section 7.3 is required by
its terms but is for any reason held to be unavailable to or otherwise
insufficient to hold harmless an indemnified party under paragraphs (a), (b) or
(c) of this Section 7.3 in respect to any losses, claims, damages, liabilities
or expenses referred to herein, then each applicable indemnifying party shall
contribute to the amount paid or payable by such indemnified party as a result
of any losses, claims, damages, liabilities or expenses referred to herein (i)
in such proportion as is appropriate to reflect the relative benefits received
by the Company and the Purchaser from the placement of the Preferred Stock or
(ii) if the allocation provided by clause (i) above is not permitted by
applicable law, in such proportion as is appropriate to reflect not only the
relative benefits referred to in clause (i) above but the relative fault of the
Company and the Purchaser in 

                                      -14-

<PAGE>

connection with the statements or omissions or inaccuracies in the 
representations and warranties in this Agreement which resulted in such 
losses, claims, damages, liabilities or expenses, as well as any other 
relevant equitable considerations.  The respective relative benefits received 
by the Company on the one hand and each Purchaser on the other shall be 
deemed to be in the same proportion as the amount paid by such Purchaser to 
the Company pursuant to this Agreement for the Shares purchased by such 
Purchaser into which the Underlying Shares that were sold pursuant to the 
Registration Statement were converted bears to the difference (the 
"Difference") between the amount such Purchaser paid for the Shares purchased 
by such Purchaser into which the Underlying Shares that were sold pursuant to 
the Registration Statement were converted and the amount received by such 
Purchaser from such sale of the Underlying Shares.  The relative fault of 
such Selling Stockholders and each Purchaser shall be determined by reference 
to, among other things, whether the untrue or alleged statement o a material 
fact or the omission or alleged omission to state a material fact or the 
inaccurate or the alleged inaccurate representation and/or warranty relates 
to information supplied by the Company or by such Purchaser and the parties' 
relative intent, knowledge, access to information and opportunity to correct 
or prevent such statement or omission. The amount paid or payable by a party 
as a result of the losses, claims, damages, liabilities and expenses referred 
to above shall be deemed to include, subject to the limitations set forth in 
paragraph (c) of this Section 7.3, any legal or other fees or expenses 
reasonably incurred by such party in connection with investigating or 
defending any action or claim.  The provisions set forth in paragraph (c) of 
this Section 7.3 with respect to the notice of the threat or commencement of 
any threat or action shall apply if a claim for contribution is to be made 
under this paragraph (d); PROVIDED, HOWEVER, that no additional notice shall 
be required with respect to any threat or action for which notice has been 
given under paragraph (c) for purposes of indemnification.  The Company and 
each Purchaser agree that it would not be just and equitable if contribution 
pursuant to this Section 7.3 were determined solely by pro rata allocation 
(even if the Purchaser were treated as one entity for such purpose) or by any 
other method of allocation which does not take account of the equitable 
considerations referred to in this paragraph.  Notwithstanding the provisions 
of this Section 7.3, no Purchaser shall be required to contribute any amount 
in excess of the amount by which the Difference exceeds the amount of any 
damages that such Purchaser has otherwise been required to pay by reason of 
such untrue or alleged untrue statement or omission or alleged omission.  No 
person guilty of fraudulent misrepresentation (within the meaning of Section 
11(f) of the Securities Act) shall be entitled to contribution from any 
person who was not guilty of such fraudulent misrepresentation.  The 
Purchasers' obligations to contribute pursuant to this Section 7.3 are 
several and not joint.

     7.4.  TERMINATION OF CONDITIONS AND OBLIGATIONS.  The conditions 
precedent imposed by Section 5 or this Section 7 upon the transferability of 
the Shares and the Underlying Shares shall cease and terminate as to any 
particular number of the Shares or Underlying Shares upon the passage of 
twenty-four months from the Closing Date or at such time as an opinion of 
counsel satisfactory in form and substance to the Company shall have been 
rendered to the effect that such conditions are not necessary in order to 
comply with the Securities Act. 

     7.5.  INFORMATION AVAILABLE.  So long as the Registration Statement is
effective covering the resale of Underlying Shares owned by the Purchaser, the
Company will furnish to 

                                      -15-

<PAGE>

the Purchaser: 

     (a)  as soon as practicable after available (but in the case of the
          Company's Annual Report to Stockholders, within 120 days after the end
          of each fiscal year of the Company), one copy of (i) its Annual Report
          to Stockholders (which Annual Report shall contain financial
          statements audited in accordance with generally accepted accounting
          principles by a national firm of certified public accountants), (ii)
          if not included in substance in the Annual Report to Stockholders, its
          Annual Report on Form 10-K, (iii) if not included in substance in its
          Quarterly Reports to Shareholders, its quarterly reports on Form 10-Q,
          and (iv) a full copy of the particular Registration Statement covering
          the Underlying Shares (the foregoing, in each case, excluding
          exhibits); 

     (b)  upon the reasonable request of the Purchaser, a reasonable number of
          copies of the prospectuses to supply to any other party requiring such
          prospectuses; 

and the Company, upon the reasonable request of the Purchaser, will meet with
the Purchaser or a representative thereof at the Company's headquarters to
discuss information relevant for disclosure in the Registration Statement
covering the Underlying Shares subject to appropriate confidentiality
limitations. 

     SECTION 8.  BROKER'S FEE.  The Purchaser acknowledges that the Company
intends to pay to the Placement Agent a fee in respect of the sale of the Shares
to the Purchaser.  Each of the parties hereto hereby represents that, on the
basis of any actions and agreements by it, there are no other brokers or finders
entitled to compensation in connection with the sale of the Shares to the
Purchaser.

     SECTION 9.  NOTICES.  All notices, requests, consents and other
communications hereunder shall be in writing, shall be mailed by first-class
registered or certified airmail, confirmed facsimile or nationally recognized
overnight express courier postage prepaid, and shall be deemed given when so
mailed and shall be delivered as addressed as follows: 

     (a)  if to the Company, to:

               Triangle Pharmaceuticals, Inc.
               4 University Place
               4611 University Drive
               Durham, North Carolina 27707
               Attn:     General Counsel

                                      -16-

<PAGE>

          with a copy to:

               Brobeck, Phleger & Harrison LLP
               550 West C Street
               Suite 1300
               San Diego, California 92101
               Attn:     John A. Denniston, Esq.

          or to such other person at such other place as the Company shall
          designate to the Purchaser in writing; and

     (b)  if to the Purchaser, at its address as set forth at the end of this
          Agreement, or at such other address or addresses as may have been
          furnished to the Company in writing.

     SECTION 10.  CHANGES.  This Agreement may not be modified or amended except
pursuant to an instrument in writing signed by the Company and the Purchaser. 

     SECTION 11.  HEADINGS.  The headings of the various sections of this
Agreement have been inserted for convenience of reference only and shall not be
deemed to be part of this Agreement. 

     SECTION 12.   SEVERABILITY.  In case any provision contained in this
Agreement should be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained
herein shall not in any way be affected or impaired thereby. 

     SECTION 13.  GOVERNING LAW.  This Agreement shall be governed by and
construed in accordance with the laws of the State of New York and the federal
law of the United States of America. 

     SECTION 14.  COUNTERPARTS.  This Agreement may be executed in two or more
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument, and shall become effective
when one or more counterparts have been signed by each party hereto and
delivered to the other parties.


                                      -17-

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed by their duly authorized representatives as of the day and year first
above written. 


                         TRIANGLE PHARMACEUTICALS, INC.
     

                                             By
                                               --------------------------------


Print or Type:
                                             Name of Purchaser
                                              (Individual or Institution):


                                               --------------------------------

                                             Name of Individual representing
                                              Purchaser (if an Institution):


                                               --------------------------------

                                             Title of Individual representing
                                              Purchaser (if an Institution):


                                               --------------------------------

Signature by:
                                             Individual Purchaser or Individual
                                              representing Purchaser:


                                               --------------------------------

                                             Address:    
                                                         --------------------- 
                                             Telephone: 
                                                         --------------------- 

                                             Telecopier: 
                                                         --------------------- 


                                      -18-

<PAGE>


                       SUMMARY INSTRUCTION SHEET FOR PURCHASER

                      (to be read in conjunction with the entire
                          Purchase Agreement which follows)


A.   Complete the following items on BOTH Purchase Agreements:

     1.   Page 18 - Signature:

      (i) Name of Purchaser (Individual or Institution)
     (ii) Name of Individual representing Purchaser (if an Institution)
    (iii) Title of Individual representing Purchaser (if an Institution)
     (iv) Signature of Individual Purchaser or Individual representing Purchaser

     
2.   Appendix I - Stock Certificate Questionnaire:

          Provide the information requested by the Stock Certificate
          Questionnaire.

          Appendix I - Registration Statement Questionnaire:

          Provide the information requested by the Registration Statement
          Questionnaire.

     3.   Return BOTH properly completed and signed Purchase Agreements
          including the properly completed Appendix I to:

          Vector Securities International, Inc.
          Suite 350
          1751 Lake Cook Road
          Deerfield, Illinois  60015
          Attn: Bernhard Hoffmann

B.   Instructions regarding the transfer of funds for the purchase of Shares
     will be sent by facsimile to the Purchaser by the Placement Agent at a
     later date.

C.   Upon conversion of the Shares into Underlying Shares, the Purchaser shall,
     within 10 days, complete and deliver to the Company the Registration
     Statement Questionnaire, attached hereto as Appendix I, for use by the
     Company in preparation of the Registration Statement.

D.   Upon the resale of the Underlying Shares by the Purchasers after the
     Registration Statement covering the Underlying Shares is effective, as
     described in the Purchase Agreement, the Purchaser:

          (i)  must deliver a current prospectus of the Company to the buyer
               (prospectuses must be obtained from the Company at the
               Purchaser's 



<PAGE>

               request); and

          (ii) must send a letter in the form of Appendix II to the Company so
               that the  Underlying Shares may be properly transferred.

<PAGE>

                                                                    APPENDIX I
                                                                  (one of two)


TRIANGLE PHARMACEUTICALS, INC.

STOCK CERTIFICATE QUESTIONNAIRE



     Pursuant to Section 3 of the Agreement, please provide us with the
following information: 

1.   The exact name that your Shares are to be 
     registered in (this is the name that will appear 
     on your stock certificate(s)).  You may use a 
     nominee name if appropriate:                      ------------------------

2.   The relationship between the Purchaser of the 
     Shares and the Registered Holder listed 
     in response to item 1 above:                      ------------------------

3.   The mailing address of the Registered Holder 
     listed in response to item 1 above:               ------------------------

                                        
                                                       ------------------------

                    
                                                       ------------------------


                                                       ------------------------

4.   The Social Security Number or Tax 
     Identification Number of the Registered 
     Holder listed in response to item 1 above:        ------------------------


<PAGE>

                                                                     APPENDIX I
                                                                   (two of two)
     
                    TRIANGLE PHARMACEUTICALS, INC.
                 REGISTRATION STATEMENT QUESTIONNAIRE


     In connection with the preparation of the Registration Statement, please
provide us with the following information:

     1.   Pursuant to the "Selling Shareholder" section of the Registration
Statement, please state your or your organization's name exactly as it should
appear in the Registration Statement:

     2.   Please provide the number of shares that you or your organization will
own immediately after Closing, including those Underlying Shares issued upon
conversion of the Shares purchased by you or your organization pursuant to this
Purchase Agreement and those shares of Common Stock purchased by you or your
organization through other transactions:  


     3.   Have you or your organization had any position, office or other
material relationship within the past three years with the Company or its
affiliates? 


          _____ Yes         _____ No 

     If yes, please indicate the nature of any such relationships below: 

     _________________________________________________________________ 

     _________________________________________________________________ 
      
     _________________________________________________________________

<PAGE>
                                                                    APPENDIX II



Attention:

     PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

     The undersigned, [an officer of, or other person duly authorized by]
_____________________________________________________________  
  [fill in official name of individual or institution] hereby 

certifies that he/she [said institution] is the Purchaser of the shares 
evidenced by the attached certificate, and as such, sold such shares on
_____________ in accordance with
   [date]

Registration Statement number _____________________________________
                              [fill in the number of or otherwise 

________________________________ and the requirement of delivering a
identify Registration Statement] 

current prospectus by the Company has been complied with in connection 
with such sale. 

Print or Type: 

          Name of Purchaser
            (Individual or
             Institution):
                                -----------------------

          Name of Individual
            representing
            Purchaser (if an
            Institution)   
                                -----------------------

          Title of Individual
            representing
            Purchaser (if an
            Institution):  
                                -----------------------

Signature by:

          Individual Purchaser
            or Individual repre-
            senting Purchaser:  
                                -----------------------

<PAGE>

                                     EXHIBIT A
                                          
                                          
                      CERTIFICATE OF DESIGNATIONS, PREFERENCES
                                          
                         AND RIGHTS OF THE PREFERRED STOCK



<PAGE>


Exhibit 99.1
- ------------


CONTACT:
Carolyn Underwood                            Douglas MacDougall 
Vice President, Commercial Operations        Priscilla Harlan
Triangle Pharmaceuticals, Inc.               Feinstein Kean Partners Inc.
(919) 493-5980                               (617) 577-8110
 
FOR IMMEDIATE RELEASE:
- ----------------------
                                       
                        TRIANGLE PHARMACEUTICALS ANNOUNCES 
                             SALE OF PREFERRED STOCK

DURHAM, NC, DECEMBER 28, 1998 - Triangle Pharmaceuticals, Inc. (Nasdaq:  
VIRS) today announced the sale of 170,000 shares of Preferred Stock to 
selected institutional investors for $17 million. Vector Securities 
International, Inc. served as placement agent for the financing.

Each share of Preferred Stock will convert into ten shares of Common Stock 
upon the earlier of receipt of stockholder approval or the first anniversary 
of the closing of the sale.  The holders of the Preferred Stock remaining 
outstanding after June 15, 1999 shall receive a dividend of $5.00 per share 
upon the conversion of the Preferred Stock into Common Stock.  This dividend 
will be payable, at the Company's option, in cash or Common Stock.  The 
Company has also agreed to file a resale registration statement with the 
Securities and Exchange Commission relating to the sale of the Common Stock 
issuable upon conversion of the Preferred Stock within 30 days after the 
conversion date.

The Company intends to use the net proceeds from the sale of the preferred 
stock for general corporate purposes, including drug development programs 
such as preclinical testing and clinical trials, the payment of license fees, 
the costs of obtaining patent protection and other payments to licensors, the 
potential acquisition of additional drug candidates, the development of a 
commercial infrastructure, the development of computerized systems to support 
clinical trials and working capital.
 
This sale is in addition to the 4.8 million shares of Common Stock which the 
Company agreed to sell to other institutional and accredited investors, 
previously announced in a press release dated December 15, 1998.  The closing 
of this earlier financing will occur concurrently with the declaration of 
effectiveness of a resale registration statement relating to such shares.

<PAGE>

Triangle Pharmaceuticals, Inc., based in Durham, North Carolina, is engaged 
in the development of new drug candidates primarily in the antiviral area, 
with a particular focus on therapies for the human immunodeficiency virus, 
including the acquired immunodeficiency syndrome, and hepatitis B virus.  
Prior to their employment with the Company, members of the Company's 
management team played instrumental roles in the identification, clinical 
development and commercialization of several leading antiviral therapies.  
More information about Triangle's portfolio, management and product 
development strategy is available on the Triangle website at:  
HTTP://WWW.TRIPHARM.COM. 

Statements in this press release may constitute forward-looking statements 
and are subject to numerous risks and uncertainties, including the failure to 
successfully complete pivotal clinical trials, the Company's future capital 
needs, the inability to commercialize FTC and DAPD due to other patent rights 
held by third parties, the Company's ability to obtain additional funding, 
patent protection and required regulatory approvals for its drug candidates, 
the development of competitive products by others, the cost of coactive 
therapy and the extent to which coactive therapy achieves market acceptance, 
the Company's success in identifying new drug candidates, acquiring rights to 
the candidates on favorable terms and developing any candidates to which the 
Company acquires any rights, and these and other risks detailed from time to 
time in the Company's filings with the Securities and Exchange Commission.  
The actual results may differ materially from those projected in this press 
release.  The Company disclaims any obligation to update statements in this 
press release.



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