TRIANGLE PHARMACEUTICALS INC
SC 13G/A, 1999-02-12
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
             RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                               (Amendment No. 1)*

                         TRIANGLE PHARMACEUTICALS, INC.
                        --------------------------------
                                (Name of Issuer)

                         Common Stock, $0.001 Par Value
                       ----------------------------------
                         (Title of Class of Securities)

                                    89589H104
                                 ---------------
                                 (CUSIP Number)

                                December 31, 1998
                    ---------------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [  ]     Rule 13d-1(b)
                  [X ]     Rule 13d-1(c)
                  [  ]     Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 or  otherwise  subject to the  liabilities  of that  section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).




                         Continued on following page(s)
                               Page 1 of 16 Pages


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 2 of 16 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  CAYMAN ISLANDS

                           5        Sole Voting Power
 Number of                                  1,000,000
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  0
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   1,000,000
    With
                           8        Shared Dispositive Power
                                            0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    4.15%

12       Type of Reporting Person*

                  OO; IV

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 3 of 16 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                           5        Sole Voting Power
 Number of                                  1,000,000
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  0
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   1,000,000
    With
                           8        Shared Dispositive Power
                                            0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    4.15%

12       Type of Reporting Person*

                  PN; IA

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 4 of 16 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                           5        Sole Voting Power
 Number of                                  1,000,000
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  0
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   1,000,000
    With
                           8        Shared Dispositive Power
                                            0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    4.15%

12       Type of Reporting Person*

                  CO

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 5 of 16 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                           5        Sole Voting Power
 Number of                                   1,989,500
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                           0
    Each
  Reporting                7       Sole Dispositive Power
   Person                                    1,989,500
    With
                           8        Shared Dispositive Power
                                                     0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,989,500

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    8.27%

12       Type of Reporting Person*

                  OO; IA

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 7 of 16 Pages



1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                           5        Sole Voting Power
 Number of                                  0
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  1,989,500
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   0
    With
                           8        Shared Dispositive Power
                                            1,989,500

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,989,500

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    8.27%

12       Type of Reporting Person*

                  IA

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 7 of 16 Pages



1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  STANLEY F. DRUCKENMILLER (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                           5        Sole Voting Power
 Number of                                  800,000
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  1,989,500
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   800,000
    With
                           8        Shared Dispositive Power
                                            1,989,500

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            2,789,500

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain Shares*
                                            [ ]

11       Percent of Class Represented By Amount in Row (9)

                                    11.59%

12       Type of Reporting Person*

                  IA

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 89589H104                                           Page 8 of 16 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  DUQUESNE CAPITAL MANAGEMENT, L.L.C.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  PENNSYLVANIA

                           5        Sole Voting Power
 Number of                                  800,000
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  0
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   800,000
    With
                           8        Shared Dispositive Power
                                            0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            800,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain Shares*
                                            [x]

11       Percent of Class Represented By Amount in Row (9)

                                    3.32%

12       Type of Reporting Person*

                  OO; IA

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 9 of 16 Pages



Item 1(a)         Name of Issuer:

                  Triangle Pharmaceuticals, Inc. (the "Issuer").

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  4 University  Place,  4611  University  Drive,  Durham,  North
Carolina, 27707.

Item 2(a)         Name of Person Filing:

                  This  statement  is filed on behalf  of each of the  following
                  persons (collectively, the "Reporting Persons"):

                  i)       Quantum  Industrial  Partners  LDC, a Cayman  Islands
                           exempted limited duration company ("QIP");

                  ii)      QIH  Management  Investor,  L.P., a Delaware  limited
                           partnership ("QIHMI");

                  iii)     QIH Management,  Inc., a Delaware  corporation  ("QIH
                           Management");

                  iv)      Soros  Fund  Management   LLC,  a  Delaware   limited
                           liability company ("SFM LLC");

                  v)       Mr. George Soros ("Mr. Soros");

                  vi)      Mr. Stanley F. Druckenmiller  ("Mr.  Druckenmiller");
                           and

                  vii)     Duquesne Capital  Management,  L.L.C., a Pennsylvania
                           limited liability company ("Duquesne LLC").

                  This Statement  relates to Shares (as defined herein) held for
the accounts of Quantum Partners LDC, a Cayman Islands exempted limited duration
company ("Quantum Partners"),  Quasar International Partners C.V., a Netherlands
Antilles  limited  partnership  ("Quasar  Partners"),  QIP, and the Duquesne LLC
Clients (as defined herein).

                  SFM LLC,  a  Delaware  limited  liability  company,  serves as
principal  investment  manager to Quantum Partners and Quasar  Partners,  and as
such,  has  been  granted  investment  discretion  over  portfolio  investments,
including  the  Shares,  held for the  accounts of Quantum  Partners  and Quasar
Partners.  QIHMI,  an  investment  advisory  firm,  is  vested  with  investment
discretion  over the Shares held for the account of QIP.  Mr.  Soros is the sole
shareholder  of QIH  Management,  the sole  general  partner  of  QIHMI  and the
Chairman  of SFM LLC.  Mr.  Druckenmiller  is the Lead  Portfolio  Manager and a
Member of the Management Committee of SFM LLC. Mr. Druckenmiller also owns a 75%
interest in, and is the sole  managing  member of,  Duquesne  LLC, an investment
advisory  firm that serves as a  discretionary  investment  advisor to a limited
number of institutional clients (the "Duquesne Clients").



<PAGE>

                               

                                                             Page 10 of 16 Pages


                  Pursuant to a combination  of Quasar  International  Fund N.V.
("Quasar Fund") with and into Quantum Industrial Holdings Ltd. ("QIH") effective
February 1, 1999,  portfolio  investments  previously  held indirectly by Quasar
Fund were transferred to, and are held indirectly by, QIH. Soros Fund Management
LLC, is  principal  investment  manager to both  Quasar  Partners  and QIH,  and
remains the principal investment manager of such portfolio investments.

Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The address of the principal business office of each of QIHMI,
QIH Management,  SFM LLC, Mr. Soros and Mr. Druckenmiller is 888 Seventh Avenue,
33rd Floor, New York, NY 10106. The address of the principal  business office of
QIP is Kaya Flamboyan 9, Willemstad,  Curacao, Netherlands Antilles. The address
of the principal  business office of Duquesne LLC is 2579 Washington Road, Suite
322, Pittsburgh, Pennsylvania 15241-2591.

Item 2(c)         Citizenship:

                  i)       QIP is a Cayman  Islands  exempted  limited  duration
                           company;

                  ii)      QIHMI is a Delaware limited partnership;

                  iii)     QIH Management is a Delaware corporation;

                  iv)      SFM LLC is a Delaware limited liability company;

                  v)       Mr. Soros is a United States citizen;

                  vi)      Mr. Druckenmiller is a United States citizen; and

                  vii)     Duquesne  LLC  is a  Pennsylvania  limited  liability
                           company.

Item 2(d)         Title of Class of Securities:

                           Common Stock, $0.001 par value (the "Shares").

Item 2(e)         CUSIP Number:

                           89589H104

Item 3.           If this  statement  is filed  pursuant  to Rule  13d-1(b),  or
                  13d-2(b), check whether the person filing is a:

                           This Item 3 is not applicable.



<PAGE>


                                                             Page 11 of 16 Pages



Item 4.           Ownership:

Item 4(a)         Amount Beneficially Owned:

                           As of February 11, 1999 each of the Reporting Persons
                           may be deemed the  beneficial  owner of the following
                           number of Shares:

                           i)       Each of QIP, QIHMI and QIH Management may be
                                    deemed the beneficial owner of the 1,000,000
                                    Shares held for the account of QIP.

                           ii)      Each of SFM LLC and Mr.  Soros may be deemed
                                    the  beneficial  owner of 1,989,500  Shares.
                                    This number  includes (A)  1,000,000  Shares
                                    held for the  account  of QIP,  (B)  964,500
                                    Shares  held  for  the  account  of  Quantum
                                    Partners and (C) 25,000  Shares held for the
                                    account of Quasar Partners.

                           iii)     Mr.   Druckenmiller   may  be   deemed   the
                                    beneficial owner of 2,789,500  Shares.  This
                                    number consists of (A) 1,000,000 Shares held
                                    for the account of QIP,  (B) 964,500  Shares
                                    held for the  account of  Quantum  Partners,
                                    (C) 25,000  Shares  held for the  account of
                                    Quasar  Partners and (D) 800,000 Shares held
                                    for  the   accounts  of  the   Duquesne  LLC
                                    Clients.

                           iv)      Duquesne  LLC may be deemed  the  beneficial
                                    owner  of the  800,000  Shares  held for the
                                    accounts of the Duquesne LLC Clients.


Item 4(b)         Percent of Class:

                           i)       The  number of Shares of which  each of QIP,
                                    QIHMI  and  QIH  may  be  deemed  to be  the
                                    beneficial owner  constitutes  approximately
                                    4.15%  of  the   total   number   of  Shares
                                    outstanding.

                           ii)      The  number  of  Shares of which SFM LLC and
                                    Mr. Soros may be deemed to be the beneficial
                                    owner constitutes approximately 8.27% of the
                                    total number of Shares outstanding.

                           iii)     The   number   of   Shares   of  which   Mr.
                                    Druckenmiller   may  be  deemed  to  be  the
                                    beneficial owner  constitutes  approximately
                                    11.59%  of  the   total   number  of  Shares
                                    outstanding.

                           iv)      The number of Shares of which  Duquesne  LLC
                                    may be  deemed  to be the  beneficial  owner
                                    constitutes approximately 3.32% of the total
                                    number of Shares outstanding.



<PAGE>


                                                             Page 12 of 16 Pages



Item 4(c) Number of shares as to which such person has:

   QIP
   ---

   (i)      Sole power to vote or to direct the vote:                  1,000,000

   (ii)     Shared power to vote or to direct the vote:                        0

   (iii)    Sole power to dispose or to direct the disposition of:     1,000,000

   (iv)     Shared power to dispose or to direct the disposition of:           0

   QIHMI
   -----

   (i)      Sole power to vote or to direct the vote:                  1,000,000

   (ii)     Shared power to vote or to direct the vote:                        0

   (iii)    Sole power to dispose or to direct the disposition of:     1,000,000

   (iv)     Shared power to dispose or to direct the disposition of            0

   QIH
   ---

   (i)      Sole power to vote or to direct the vote:                  1,000,000

   (ii)     Shared power to vote or to direct the vote:                        0

   (iii)    Sole power to dispose or to direct the disposition of:     1,000,000

   (iv)     Shared power to dispose or to direct the disposition of:          0

   SFM LLC
   -------

   (i)      Sole power to vote or to direct the vote:                  1,989,500

   (ii)     Shared power to vote or to direct the vote:                        0

   (iii)    Sole power to dispose or to direct the disposition of:     1,989,500

   (iv)     Shared power to dispose or to direct the disposition of:           0



<PAGE>


                                                             Page 13 of 16 Pages


   Mr. Soros
   ---------

   (i)      Sole power to vote or to direct the vote:                          0

   (ii)     Shared power to vote or to direct the vote:                1,989,500

   (iii)    Sole power to dispose or to direct the disposition of:             0

   (iv)     Shared power to dispose or to direct the disposition of    1,989,500

   Mr. Druckenmiller
   -----------------

   (i)      Sole power to vote or to direct the vote:                    800,000

   (ii)     Shared power to vote or to direct the vote:                1,989,500

   (iii)    Sole power to dispose or to direct the disposition of:       800,000

   (iv)     Shared power to dispose or to direct the disposition of:   1,989,500

   Duquesne LLC
   ------------

   (i)      Sole power to vote or to direct the vote:                    800,000

   (ii)     Shared power to vote or to direct the vote:                        0

   (iii)    Sole power to dispose or to direct the disposition of:       800,000

   (iv)     Shared power to dispose or to direct the disposition of:           0

Item 5.     Ownership of Five Percent or Less of a Class:

                      This Item 5 is not applicable.

Item 6.     Ownership of More than Five Percent on Behalf of Another Person:

            (i)       The  shareholders  of QIP,  including  Quantum  Industrial
Holdings,  Ltd., a British Virgin Islands  international  business company, have
the right to participate in the receipt of dividends  from, or proceeds from the
sale of,  the  Shares  held for the  account  of QIP in  accordance  with  their
ownership interests in QIP.

            (ii)      The shareholders of Quantum  Partners,  including  Quantum
Fund N.V., a Netherlands Antilles company,  have the right to participate in the
receipt of dividends  from,  or proceeds  from the sale of, the Shares,  held by
Quantum  Partners  in  accordance  with  their  ownership  interests  in Quantum
Partners.

            (iii)     The  partners  of  Quasar  Partners,   including   Quantum
Industrial  Partners LDC, a Cayman Islands Limited  Duration  Company,  have the
right to participate in the receipt of dividends from, or proceeds from the sale
of,  securities  held by Quasar  Partners in accordance  with their  partnership
interests in Quasar Partners.


<PAGE>

                                                             Page 14 of 16 Pages


                  (iv)     The   Duquesne   LLC   Clients   have  the  right  to
participate in the receipt of dividends  from, or proceeds from the sale of, the
Shares, held for their account.

                  Each of QIP,  QIHMI  and QIH  Management  expressly  disclaims
beneficial  ownership  of any Shares held  directly  for the accounts of Quantum
Partners,  Quasar  Partners  and the Duquesne  Clients.  Each of SFM LLC and Mr.
Soros expressly disclaims  beneficial  ownership of any Shares held directly for
the  accounts  of  the  Duquesne  Clients.   Duquesne  LLC  expressly  disclaims
beneficial  ownership  of any  Shares  held  for the  accounts  of QIP,  Quantum
Partners and Quasar Partners.

Item 7.           Identification  and  Classification  of the  Subsidiary  Which
                  Acquired the Security  Being Reported on by the Parent Holding
                  Company:

                           This Item 7 is not applicable.

Item 8.           Identification and Classification of Members of the Group:

                           This Item 8 is not applicable.

Item 9.           Notice of Dissolution of Group:

                           This Item 9 is not applicable.

Item 10.          Certification:

                  By signing below each signatory certifies that, to the best of
his/its knowledge and belief, the securities referred to above were not acquired
and  are  not  held  for the  purpose  of or with  the  effect  of  changing  or
influencing  the control of the Issuer of the  securities  and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having that purpose or effect.


<PAGE>


                                                             Page 15 of 16 Pages


                                   SIGNATURES


After  reasonable  inquiry  and to the  best of my  knowledge  and  belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Date:  February 12, 1999                    QUANTUM INDUSTRIAL PARTNERS LDC


                                            By:   /S/ MICHAEL S. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact


Date:  February 12, 1999                    QIH MANAGEMENT INVESTOR, L.P.

                                            By:      QIH Management, Inc.,
                                                     its General Partner


                                                     By:    /S/ MICHAEL C. NEUS
                                                            --------------------
                                                            Michael C. Neus
                                                            Vice President


Date:  February 12, 1999                   QIH MANAGEMENT, INC.


                                            By:   /S/ MICHAEL S. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Vice President



Date:  February 12, 1999                    SOROS FUND MANAGEMENT LLC



                                            By:   /S/ MICHAEL S. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Assistant General Counsel


Date:  February 12, 1999                    GEORGE SOROS



                                            By:   /S/ MICHAEL S. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact

<PAGE>


                                                             Page 16 of 16 Pages


Date:  February 12, 1999                    STANLEY F. DRUCKENMILLER


                                            By:   /S/ MICHAEL S. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact


Date:  February 12, 1999                   DUQUESNE CAPITAL MANAGEMENT, L.L.C.


                                            By:   /S/ GERALD KERNER
                                                  ------------------------------
                                                  Gerald Kerner
                                                  Managing Director




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