TRIANGLE PHARMACEUTICALS INC
SC 13G/A, 1999-02-08
PHARMACEUTICAL PREPARATIONS
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                          SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, D.C. 20549
                                 ____________________

                                    SCHEDULE 13G/A
                                    (RULE 13d-102)

               INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT 
             TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED 
                                   PURSUANT TO 13d-2(b)

                                   (Amendment No. 2)*

                            TRIANGLE PHARMACEUTICALS, INC.
 -------------------------------------------------------------------------------
                                   (NAME OF ISSUER)




                                     COMMON STOCK
 -------------------------------------------------------------------------------
                            (TITLE OF CLASS OF SECURITIES)



                                      89589H 10 4
 -------------------------------------------------------------------------------
                                    (CUSIP NUMBER)

 -------------------------------------------------------------------------------
              (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)

                                  _________________

Check the appropriate box to designate the rule pursuant to which this
  Schedule is Filed:

  [ ] Rule 13d-1(b)

  [X] Rule 13d-1(c)

  [ ] Rule 13d-1(d)

- -------------------
   *The remainder of  this cover  page  shall  be  filled  out  for a reporting
person's  initial  filing on this  form with  respect to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

   The information  required in the  remainder of this  cover page shall not be
deemed to be "filed"  for the purpose of  Section 18 of the Securities Exchange
Act of 1934  ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however, see
the Notes).

                           (CONTINUED ON FOLLOWING PAGE(S))

                                  (PAGE 1  of 5 PAGES)

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- -------------------------------                         -----------------------
CUSIP NO.   89589H 10 4               13G               Page 2  of 5  Pages
- -------------------------------                         -----------------------

- -------------------------------------------------------------------------------
 (1) NAMES OF REPORTING PERSONS.
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          DAVID W. BARRY, M.D.
- -------------------------------------------------------------------------------
 (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* 
                                                            (a)  / /  (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC USE ONLY

- -------------------------------------------------------------------------------
 (4) CITIZENSHIP OR PLACE OF ORGANIZATION
               United States
- -------------------------------------------------------------------------------
NUMBER OF SHARES              (5) SOLE VOTING POWER
 BENEFICIALLY                        798,881(+) shares of Common Stock
 OWNED BY                    --------------------------------------------------
 EACH REPORTING               (6) SHARED VOTING POWER
 PERSON WITH                         527,648(++)
                             --------------------------------------------------
                              (7) SOLE DISPOSITIVE POWER
                                     798,881(+) shares of Common Stock
                             --------------------------------------------------
                              (8) SHARED DISPOSITIVE POWER
                                     527,648(++)
- -------------------------------------------------------------------------------
 (9) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
               1,326,529(+)(++) shares of Common Stock
- -------------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                           / /
- -------------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
               4.6% as of December 31, 1998
- -------------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON*
               IN
- -------------------------------------------------------------------------------
                    *SEE INSTRUCTIONS BEFORE FILLING OUT!

+  Includes 50,381 shares of Common Stock issuable upon the exercise of 
   options that are exercisable within 60 days of December 31, 1998.
++ Includes (i) 27,648 shares of Common Stock held by the Barry Charitable 
   Foundation, Inc., a charitable North Carolina corporation of which Dr. 
   Barry serves as President, and (ii) 500,000 shares of Common Stock held by 
   Barry Asset Partners, L.P., a Georgia limited partnership of which Dr. 
   Barry is a general and a limited partner.

<PAGE>

                                                               Page 3 of 5 Pages

ITEM 1(a)     NAME OF ISSUER:
        
              Triangle Pharmaceuticals, Inc.
        
        
ITEM 1(b)     ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
        
              4 University Place
              4611 University Drive
              Durham, NC 27707
        
        
ITEM 2(a)     NAME OF PERSON FILING:
        
              David W. Barry, M.D.
        
        
ITEM 2(b)     ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
        
              Triangle Pharmaceuticals, Inc.
              4 University Place
              4611 University Drive
              Durham, NC 27707
        
        
ITEM 2(c)     CITIZENSHIP:
        
              United States
        
        
ITEM 2(d)     TITLE OF CLASS OF SECURITIES:
        
              Common Stock
        
ITEM 2(e)     CUSIP NUMBER:

              89589H 10 4

<PAGE>

                                                               Page 4 of 5 Pages

ITEM 3.       IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b) OR
              13d-2(b), CHECK WHETHER THE PERSON FILING IS A:

              Not Applicable


ITEM 4.       OWNERSHIP.

              (a)  Amount Beneficially Owned:  1,326,529(+)(++) shares of Common
                   Stock

              (b)  Percent of Class:  4.6%

              (c)  Number of shares as to which such person has:

                   (i)       sole power to vote or to direct the vote:
                             798,881(+)

                   (ii)      shared power to vote or to direct the vote:  
                             527,648(++)

                   (iii)     sole power to dispose or to direct the disposition
                             of:  798,881(+)

                   (iv)      shared power to dispose or to direct the
                             disposition of:  527,648(++)

+  Includes 50,381 shares of Common Stock issuable upon the exercise of 
   options that are exercisable within 60 days of December 31, 1998.
++ Includes (i) 27,648 shares of Common Stock held by the Barry Charitable 
   Foundation, Inc., a charitable North Carolina corporation of which Dr. 
   Barry serves as President, and (ii) 500,000 shares of Common Stock held by 
   Barry Asset Partners, L.P., a Georgia limited partnership of which Dr. 
   Barry is a general and a limited partner.


ITEM 5.       OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

              Not Applicable


ITEM 6.       OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

              Not Applicable


ITEM 7.       IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
              ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
              COMPANY.

              Not Applicable

<PAGE>

                                                               Page 5 of 5 Pages

ITEM 8.       IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

              Not Applicable


ITEM 9.       NOTICE OF DISSOLUTION OF GROUP.

              Not Applicable


ITEM 10.      CERTIFICATION.

              By signing below I certify that, to the best of my knowledge
              and belief, the securities referred to above were not acquired
              and are not held for the purpose of or with the effect of 
              changing or influencing the control of the issuer of the 
              securities and were not acquired and are not held in connection
              with or as a participant in any transaction having that purpose
              or effect.


                                      SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Date:  February 1, 1999



Signature:  /s/ David W. Barry, M.D.
          --------------------------------



Name/Title:        David W. Barry, M.D.



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