TRIANGLE PHARMACEUTICALS INC
SC 13G/A, 2000-02-14
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)


           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
                RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO
                         FILED PURSUANT TO RULE 13d-2(b)

                               (Amendment No. 2)*

                         TRIANGLE PHARMACEUTICALS, INC.
                         ______________________________
                                (Name of Issuer)


                         Common Stock, $0.001 Par Value
                         ______________________________
                         (Title of Class of Securities)

                                    89589H104
                                 ______________
                                 (CUSIP Number)

                                December 31, 1999
                      ____________________________________
                      (Date of Event which Requires Filing
                               of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]     Rule 13d-1(b)
                  [X]     Rule 13d-1(c)
                  [ ]     Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter disclosure
provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




                         Continued on following page(s)
                               Page 1 of 15 Pages






<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 2 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group*

                                   a.   [ ]
                                   b.   [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  CAYMAN ISLANDS

                             5               Sole Voting Power
Number of                                             1,000,000
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            0
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            1,000,000
    With
                             8               Shared Dispositive Power
                                                      0


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000  /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.66%

12       Type of Reporting Person*

                  OO; IV


/1/      Position as of February 10, 2000.


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!



<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 3 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group*

                                    a.  [ ]
                                    b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                             5               Sole Voting Power
Number of                                             1,000,000
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            0
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            1,000,000
    With
                             8               Shared Dispositive Power
                                                      0


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000 /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.66%

12       Type of Reporting Person*

                  PN; IA



/1/      Position as of February 10, 2000.


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 4 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group*

                                    a.  [ ]
                                    b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                             5               Sole Voting Power
Number of                                             1,000,000
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            0
    Each
Reporting                    7               Sole Dispositive Power
  Person                                              1,000,000
   With
                             8               Shared Dispositive Power
                                                      0


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000 /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.66%

12       Type of Reporting Person*

                  CO



/1/      Position as of February 10, 2000.

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 5 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group*

                                    a.  [ ]
                                    b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                             5               Sole Voting Power
Number of                                             1,964,500
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            0
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            1,964,500
    With
                             8               Shared Dispositive Power
                                                      0


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,964,500  /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    5.23%

12       Type of Reporting Person*

                  OO; IA


/1/      Position as of February 10, 2000.


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 6 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*

                                    a.  [ ]
                                    b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                             5               Sole Voting Power
Number of                                             0
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            1,964,500
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            0
    With
                             8               Shared Dispositive Power
                                                      1,964,500


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,964,500 /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    5.23%

12       Type of Reporting Person*

                  IA


/1/      Position as of February 10, 2000.


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 7 of 15 Pages





1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  STANLEY F. DRUCKENMILLER (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*

                                   a.   [ ]
                                   b.   [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                             5               Sole Voting Power
Number of                                             775,000
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            1,964,500
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            775,000
    With
                             8               Shared Dispositive Power
                                                      1,964,500


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  2,739,500 /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                     [   ]

11       Percent of Class Represented By Amount in Row (9)

                                    7.29%

12       Type of Reporting Person*

                  IA


/1/      Position as of February 10, 2000.


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 8 of 15 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  DUQUESNE CAPITAL MANAGEMENT, L.L.C.

2        Check the Appropriate Box If a Member of a Group*

                                    a.  [ ]
                                    b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  PENNSYLVANIA

                             5               Sole Voting Power
Number of                                             775,000
  Shares
Beneficially                 6               Shared Voting Power
  Owned By                                            0
    Each
Reporting                    7               Sole Dispositive Power
    Person                                            775,000
    With
                             8               Shared Dispositive Power
                                                      0


9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  775,000 /1/

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.00%

12       Type of Reporting Person*

                  OO; IA


/1/      Position as of February 10, 2000.


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>



                                                              Page 9 of 15 Pages




Item 1(a)         Name of Issuer:

                  Triangle Pharmaceuticals, Inc.  (the "Issuer").

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  4 University  Place,  4611  University  Drive,  Durham,  North
Carolina 27707

Item 2(a)         Name of Person Filing:

                  The  Statement  is filed on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

                  i)       Quantum  Industrial  Partners  LDC, a Cayman  Islands
                           exempted limited duration company ("QIP");

                  ii)      QIH  Management  Investor,  L.P., a Delaware  limited
                           partnership ("QIHMI");

                  iii)     QIH Management,  Inc., a Delaware  corporation  ("QIH
                           Management");

                  iv)      Soros  Fund  Management   LLC,  a  Delaware   limited
                           liability company ("SFM LLC");

                  v)       Mr. George Soros ("Mr. Soros");

                  vi)      Mr. Stanley F. Druckenmiller  ("Mr.  Druckenmiller");
                           and

                  vii)     Duquesne Capital  Management,  L.L.C., a Pennsylvania
                           limited liability company ("Duquesne LLC").

                  This Statement  relates to Shares (as defined herein) held for
the accounts of Quantum Partners LDC, a Cayman Islands exempted limited duration
company  ("Quantum  Partners"),  QIP and the  Duquesne  LLC  Clients (as defined
herein).

                  SFM LLC  serves as  principal  investment  manager  to Quantum
Partners. As such, SFM LLC has been granted investment discretion over portfolio
investments, including the Shares, held for the account of Quantum Partners. Mr.
Soros is Chairman of SFM LLC. Mr.  Druckenmiller  is the Lead Portfolio  Manager
and a Member of the Management Committee of SFM LLC.

                  QIHMI, an investment  advisory firm, is vested with investment
discretion  over the Shares held for the account of QIP.  Mr.  Soros is the sole
shareholder of QIH Management,  which is the sole general partner of QIHMI.  Mr.
Soros has entered into an  agreement  pursuant to which he has agreed to use his
best efforts to cause QIH Management, as the general partner of QIHMI, to act at
the direction of SFM LLC.

                  Mr.  Druckenmiller  owns a 75%  interest  in,  and is the sole
managing member of,  Duquesne LLC, an investment  advisory firm that serves as a
discretionary  investment  advisor to a limited number of institutional  clients
(the "Duquesne LLC Clients").


<PAGE>


                                                             Page 10 of 15 Pages


Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The address of the principal business office of each of QIHMI,
QIH Management,  SFM LLC, Mr. Soros and Mr. Druckenmiller is 888 Seventh Avenue,
33rd Floor, New York, NY 10106. The address of the principal  business office of
QIP is Kaya Flamboyan 9, Willemstad,  Curacao, Netherlands Antilles. The address
of the principal  business office of Duquesne LLC is 2579 Washington Road, Suite
322, Pittsburgh, Pennsylvania 15241-2591.

Item 2(c)         Citizenship:

                  i)       QIP is a Cayman  Islands  exempted  limited  duration
                           company;

                  ii)      QIHMI is a Delaware limited partnership;

                  iii)     QIH Management is a Delaware corporation;

                  iv)      SFM LLC is a Delaware limited liability company;

                  v)       Mr. Soros is a United States citizen;

                  vi)      Mr. Druckenmiller is a United States citizen; and

                  vii)     Duquesne  LLC  is a  Pennsylvania  limited  liability
                           company.

Item 2(d)         Title of Class of Securities:

                  Common Stock, $0.001 par value (the "Shares").

Item 2(e)         CUSIP Number:

                  89589H104

Item 3.           If this  statement  is filed  pursuant  to Rule  13d-1(b),  or
                  13d-2(b), check whether the person filing is a:

                  This Item 3 is not applicable.

Item 4.           Ownership:

Item 4(a)         Amount Beneficially Owned:

                  As of February 10, 2000, each of the Reporting  Persons may be
deemed the beneficial owner of the following number of Shares:

                  i)       Each of QIP,  QIHMI and QIH  Management may be deemed
                           the beneficial owner of the 1,000,000 Shares held for
                           the account of QIP.


<PAGE>

                                                             Page 11 of 15 Pages


                  (ii)     Each  of SFM  LLC and Mr.  Soros  may be  deemed  the
                           beneficial  owner of  1,964,500  Shares.  This number
                           includes (A) 1,000,000 Shares held for the account of
                           QIP and (B)  964,500  Shares  held for the account of
                           Quantum Partners.

                  (iii)    Mr.  Druckenmiller may be deemed the beneficial owner
                           of  2,739,500  Shares.  This  number  consists of (A)
                           1,000,000  Shares  held for the  account of QIP,  (B)
                           964,500  Shares  held  for  the  account  of  Quantum
                           Partners and (C) 775,000 Shares held for the accounts
                           of the Duquesne LLC Clients.

                  (iv)     Duquesne  LLC may be deemed the  beneficial  owner of
                           the  775,000  Shares  held  for the  accounts  of the
                           Duquesne LLC Clients.

Item 4(b)         Percent of Class:

                  i)       The number of Shares of which each of QIP,  QIHMI and
                           QIH  may  be  deemed  to  be  the  beneficial   owner
                           constitutes  approximately  2.66% of the total number
                           of Shares outstanding.

                  ii)      The  number of Shares of which SFM LLC and Mr.  Soros
                           may be deemed to be the beneficial owner  constitutes
                           approximately  5.23% of the  total  number  of Shares
                           outstanding.

                  iii)     The number of Shares of which Mr.  Druckenmiller  may
                           be  deemed  to be the  beneficial  owner  constitutes
                           approximately  7.29% of the  total  number  of Shares
                           outstanding.

                  iv)      The  number of Shares  of which  Duquesne  LLC may be
                           deemed  to  be  the  beneficial   owner   constitutes
                           approximately  2.00% of the  total  number  of Shares
                           outstanding.

Item 4(c)         Number of shares as to which such person has:

     QIP
     ---

     (i)   Sole power to vote or to direct the vote:                   1,000,000

     (ii)  Shared power to vote or to direct the vote:                         0

     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv)  Shared power to dispose or to direct the disposition of:            0

     QIHMI
     -----

     (i)   Sole power to vote or to direct the vote:                   1,000,000

     (ii)  Shared power to vote or to direct the vote:                         0


<PAGE>

                                                             Page 12 of 15 Pages



     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv)  Shared power to dispose or to direct the disposition of:            0

     QIH
     ---

     (i)   Sole power to vote or to direct the vote:                   1,000,000

     (ii)  Shared power to vote or to direct the vote:                         0

     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv)  Shared power to dispose or to direct the disposition of:            0

     SFM LLC
     -------

     (i)   Sole power to vote or to direct the vote:                   1,964,500

     (ii)  Shared power to vote or to direct the vote:                         0

     (iii) Sole power to dispose or to direct the disposition of:      1,964,500

     (iv)  Shared power to dispose or to direct the disposition of:            0

     Mr. Soros
     ---------

     (i)   Sole power to vote or to direct the vote:                           0

     (ii)  Shared power to vote or to direct the vote:                 1,964,500

     (iii) Sole power to dispose or to direct the disposition of:              0

     (iv)  Shared power to dispose or to direct the disposition of:    1,964,500

     Mr. Druckenmiller
     -----------------

     (i)   Sole power to vote or to direct the vote:                     775,000

     (ii)  Shared power to vote or to direct the vote:                 1,964,500

     (iii) Sole power to dispose or to direct the disposition of:        775,000

     (iv)  Shared power to dispose or to direct the disposition of:    1,964,500


     Duquesne LLC
     ------------

     (i)   Sole power to vote or to direct the vote:                     775,000

     (ii)  Shared power to vote or to direct the vote:                         0


<PAGE>

                                                             Page 13 of 15 Pages


     (iii) Sole power to dispose or to direct the disposition of:        775,000

     (iv)  Shared power to dispose or to direct the disposition of:            0


Item 5.           Ownership of Five Percent or Less of a Class:

                           This Item 5 is not applicable.

Item 6.           Ownership  of More than  Five  Percent  on  Behalf of  Another
                  Person:

                  (i)      The shareholders of QIP, including Quantum Industrial
Holdings,  Ltd., a British Virgin Islands  international  business company, have
the right to participate in the receipt of dividends  from, or proceeds from the
sale of,  the  Shares  held for the  account  of QIP in  accordance  with  their
ownership interests in QIP.

                  (ii)     The  shareholders  of  Quantum  Partners,   including
Quantum Fund N.V., a Netherlands Antilles company, have the right to participate
in the receipt of dividends  from, or proceeds from the sale of, the Shares held
by Quantum  Partners in  accordance  with their  ownership  interests in Quantum
Partners.

                  (iii)    The   Duquesne   LLC   Clients   have  the  right  to
participate in the receipt of dividends  from, or proceeds from the sale of, the
Shares held for their account.

                  Each of QIP,  QIHMI  and QIH  Management  expressly  disclaims
beneficial  ownership  of any Shares held  directly  for the accounts of Quantum
Partners and the Duquesne LLC Clients.  Each of SFM LLC and Mr. Soros  expressly
disclaims  beneficial  ownership of any Shares held directly for the accounts of
the Duquesne LLC Clients.  Duquesne LLC expressly disclaims beneficial ownership
of any Shares held for the accounts of QIP and Quantum Partners.

Item 7.           Identification  and  Classification  of the  Subsidiary  Which
                  Acquired the Security  Being Reported on by the Parent Holding
                  Company:

                           This Item 7 is not applicable.

Item 8.           Identification and Classification of Members of the Group:

                           This Item 8 is not applicable.

Item 9.           Notice of Dissolution of Group:

                           This Item 9 is not applicable.

Item 10.          Certification:

                  By signing below each signatory certifies that, to the best of
his/its knowledge and belief, the securities referred to above were not acquired
and  are  not  held  for the  purpose  of or with  the  effect  of  changing  or
influencing  the control of the Issuer of the  securities  and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having that purpose or effect.





<PAGE>



                                                             Page 14 of 15 Pages




                                   SIGNATURES


After  reasonable  inquiry  and to the  best of my  knowledge  and  belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Date:  February 10, 2000                    QUANTUM INDUSTRIAL PARTNERS LDC


                                            By:   /S/ MICHAEL C. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact


Date:  February 10, 2000                    QIH MANAGEMENT INVESTOR, L.P.

                                            By:      QIH Management, Inc.,
                                                     its General Partner


                                                     By:    /S/ MICHAEL C. NEUS
                                                            --------------------
                                                            Michael C. Neus
                                                            Vice President


Date:  February 10, 2000                   QIH MANAGEMENT, INC.


                                            By:   /S/ MICHAEL C. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Vice President



Date:  February 10, 2000                    SOROS FUND MANAGEMENT LLC



                                            By:   /S/ MICHAEL C. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Assistant General Counsel


Date:  February 10, 2000                    GEORGE SOROS



                                            By:   /S/ MICHAEL C. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact

<PAGE>


                                                             Page 15 of 15 Pages


Date:  February 10, 2000                    STANLEY F. DRUCKENMILLER


                                            By:   /S/ MICHAEL C. NEUS
                                                  ------------------------------
                                                  Michael C. Neus
                                                  Attorney-in-Fact


Date:  February 10, 2000                   DUQUESNE CAPITAL MANAGEMENT, L.L.C.


                                            By:   /S/ GERALD KERNER
                                                  ------------------------------
                                                  Gerald Kerner
                                                  Managing Director




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