TRIANGLE PHARMACEUTICALS INC
SC 13G/A, 2000-07-06
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)


           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
                RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO
                         FILED PURSUANT TO RULE 13d-2(b)

                               (Amendment No. 3)*

                         TRIANGLE PHARMACEUTICALS, INC.
                          -----------------------------
                                (Name of Issuer)

                         Common Stock, $0.001 Par Value
                         ------------------------------
                         (Title of Class of Securities)

                                    89589H104
                                    ---------
                                 (CUSIP Number)

                                  July 1, 2000
                                  ------------
                      (Date of Event which Requires Filing
                               of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]      Rule 13d-1(b)
                  [X]      Rule 13d-1(c)
                  [ ]      Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter disclosure
provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




                         Continued on following page(s)
                               Page 1 of 19 Pages
                                Exhibit Index: 16


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 2 of 19 Pages


1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  CAYMAN ISLANDS

                            5             Sole Voting Power
Number of                                          1,000,000
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         1,000,000
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.62%

12       Type of Reporting Person*

                  OO; IV


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 3 of 19 Pages


1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                            5             Sole Voting Power
Number of                                          1,000,000
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         1,000,000
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.62%

12       Type of Reporting Person*

                  PN; IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 4 of 19 Pages


1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                            5             Sole Voting Power
Number of                                          1,000,000
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
  Person                                           1,000,000
   With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    2.62%

12       Type of Reporting Person*

                  CO


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 5 of 19 Pages

1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                            5             Sole Voting Power
Number of                                          1,645,205
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         1,645,205
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,645,205

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    4.32%

12       Type of Reporting Person*

                  OO; IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 6 of 19 Pages

1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                            5             Sole Voting Power
Number of                                          1,645,205
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         1,645,205
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  1,645,205

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*

                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    4.32%

12       Type of Reporting Person*

                  IA


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 7 of 19 Pages


1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  STANLEY F. DRUCKENMILLER

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                            5             Sole Voting Power
Number of                                          202,500
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         202,500
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  202,500

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    0.53%

12       Type of Reporting Person*

                  IA


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                  SCHEDULE 13G

CUSIP No.  89589H104                                          Page 8 of 19 Pages

1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  DUQUESNE CAPITAL MANAGEMENT, L.L.C.

2        Check the Appropriate Box If a Member of a Group*

                                                a.       [ ]
                                                b.       [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  PENNSYLVANIA

                            5             Sole Voting Power
Number of                                          202,500
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                          0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                         202,500
    With
                            8             Shared Dispositive Power
                                                   0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                                  202,500

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                       [X]

11       Percent of Class Represented By Amount in Row (9)

                                    0.53%

12       Type of Reporting Person*

                  OO; IA


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

                                                              Page 9 of 19 Pages


Item 1(a)         Name of Issuer:

                  Triangle Pharmaceuticals, Inc.  (the "Issuer").

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  4 University  Place,  4611  University  Drive,  Durham,  North
Carolina 27707.

Item 2(a)         Name of Person Filing:

                  The  Statement  is filed on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

                  i)       Quantum Industrial Partners LDC ("QIP");

                  ii)      QIH Management Investor, L.P. ("QIHMI");

                  iii)     QIH Management, Inc. ("QIH Management");

                  iv)      Soros Fund Management LLC ("SFM LLC");

                  v)       Mr. George Soros ("Mr. Soros");

                  vi)      Mr. Stanley F. Druckenmiller  ("Mr.  Druckenmiller");
                           and

                  vii)     Duquesne Capital Management, L.L.C. ("Duquesne LLC").

                  This Statement  relates to Shares (as defined herein) held for
the accounts of Quantum Partners LDC, a Cayman Islands exempted limited duration
company  ("Quantum  Partners"),  QIP and the  Duquesne  LLC  Clients (as defined
herein).

                  SFM LLC  serves as  principal  investment  manager  to Quantum
Partners. As such, SFM LLC has been granted investment discretion over portfolio
investments, including the Shares, held for the account of Quantum Partners.

                  Effective as of July 1, 2000, Mr.  Druckenmiller  ceased to be
the Lead Portfolio  Manager of, and is no longer  employed by, SFM LLC and, as a
result  of a  reorganization  of SFM  LLC,  the  Management  Committee  has been
eliminated.  Mr.  Druckenmiller  no longer may be deemed the beneficial owner of
securities held for the accounts of Quantum Partners and QIP, and is no longer a
Reporting  Person.  In addition,  Duquesne LLC is no longer a Reporting  Person.
Neither  QIP,  QIHMI,  QIH  Management,  SFM LLC or Mr.  Soros may be deemed the
beneficial owner of more than five percent of the outstanding  Shares. Mr. Soros
is the Chairman and President of SFM LLC.

                  QIHMI, an investment  advisory firm, is vested with investment
discretion  over the Shares held for the account of QIP.  Mr.  Soros is the sole
shareholder of QIH Management,  which is the sole general partner of QIHMI.  Mr.
Soros has entered into an  agreement  pursuant to which he has agreed to use his
best efforts to cause QIH Management, as the general partner of QIHMI, to act at
the direction of SFM LLC.


<PAGE>

                                                             Page 10 of 19 Pages

                  Mr.  Druckenmiller  owns a 75%  interest  in,  and is the sole
managing member of,  Duquesne LLC, an investment  advisory firm that serves as a
discretionary  investment  advisor to a limited number of institutional  clients
(the "Duquesne LLC Clients").

Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The address of the principal business office of each of QIHMI,
QIH  Management,  SFM LLC and Mr. Soros is 888 Seventh Avenue,  33rd Floor,  New
York,  NY 10106.  The address of the  principal  business  office of QIP is Kaya
Flamboyan 9, Willemstad, Curacao, Netherlands Antilles.

Item 2(c)         Citizenship:

                  i)     QIP  is a  Cayman  Islands  exempted  limited  duration
                         company;

                  ii)    QIHMI is a Delaware limited partnership;

                  iii)   QIH Management is a Delaware corporation;

                  iv)    SFM LLC is a Delaware limited liability company; and

                  v)     Mr. Soros is a United States citizen.

Item 2(d)         Title of Class of Securities:

                  Common Stock, $0.001 par value (the "Shares").

Item 2(e)         CUSIP Number:

                  89589H104

Item 3.           If this  statement  is filed  pursuant  to Rule  13d-1(b),  or
                  13d-2(b), check whether the person filing is a:

                  This Item 3 is not applicable.

Item 4.           Ownership:

Item 4(a)         Amount Beneficially Owned:

                  As of  July 1,  2000,  each of the  Reporting  Persons  may be
deemed the beneficial owner of the following number of Shares:

                  (i)    Each of QIP, QIHMI and QIH Management may be deemed the
                         beneficial  owner of the 1,000,000  Shares held for the
                         account of QIP.

                  (ii)   Each  of SFM  LLC  and  Mr.  Soros  may be  deemed  the
                         beneficial  owner  of  1,645,205  Shares.  This  number
                         includes (A)  1,000,000  Shares held for the account of
                         QIP and (B)  645,205  Shares  held for the  account  of
                         Quantum Partners.

<PAGE>

                                                             Page 11 of 19 Pages

Item 4(b)         Percent of Class:

                  (i)    The  number of Shares of which  each of QIP,  QIHMI and
                         QIH  may  be   deemed  to  be  the   beneficial   owner
                         constitutes  approximately 2.62% of the total number of
                         Shares outstanding.

                  (ii)   The number of Shares of which SFM LLC and Mr. Soros may
                         be  deemed  to  be  the  beneficial  owner  constitutes
                         approximately  4.32%  of the  total  number  of  Shares
                         outstanding.

Item 4(c)        Number of shares as to which such person has:

     QIP
     ---

     (i)  Sole power to vote or to direct the vote:                    1,000,000

     (ii) Shared power to vote or to direct the vote:                          0

     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv) Shared power to dispose or to direct the disposition of:             0

     QIHMI
     -----

     (i)  Sole power to vote or to direct the vote:                    1,000,000

     (ii) Shared power to vote or to direct the vote:                          0

     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv) Shared power to dispose or to direct the disposition of:             0

     QIH
     ---

     (i)  Sole power to vote or to direct the vote:                    1,000,000

     (ii) Shared power to vote or to direct the vote:                          0

     (iii) Sole power to dispose or to direct the disposition of:      1,000,000

     (iv) Shared power to dispose or to direct the disposition of:             0

     SFM LLC
     -------

     (i)  Sole power to vote or to direct the vote:                    1,645,205

     (ii) Shared power to vote or to direct the vote:                          0

     (iii) Sole power to dispose or to direct the disposition of:      1,645,205

     (iv) Shared power to dispose or to direct the disposition of:             0
<PAGE>

                                                             Page 12 of 19 Pages

     Mr.  Soros
     ----------

     (i)  Sole power to vote or to direct the vote:                    1,645,205

     (ii) Shared power to vote or to direct the vote:                          0

     (iii) Sole power to dispose or to direct the disposition of:      1,645,205

     (iv) Shared power to dispose or to direct the disposition of:             0

Item 5.           Ownership of Five Percent or Less of a Class:

                  If this Statement is being filed to report the fact that as of
the date hereof the Reporting Persons have ceased to be the beneficial owners of
more than five percent of the class of securities, check the following [x].

Item 6            Ownership  of More than  Five  Percent  on  Behalf of  Another
                  Person:

                  (i)    The shareholders of QIP,  including Quantum  Industrial
                         Holdings,  Ltd., a British Virgin Islands international
                         business company,  have the right to participate in the
                         receipt of dividends  from,  or proceeds  from the sale
                         of,  the  Shares   held  for  the  account  of  QIP  in
                         accordance with their ownership interests in QIP.

                  (ii)   The shareholders of Quantum Partners, including Quantum
                         Endowment  Fund N.V., a Netherlands  Antilles  company,
                         have  the  right  to  participate  in  the  receipt  of
                         dividends  from,  or  proceeds  from the  sale of,  the
                         Shares  held by Quantum  Partners  in  accordance  with
                         their ownership interests in Quantum Partners.

                  Each of QIP,  QIHMI  and QIH  Management  expressly  disclaims
beneficial  ownership  of any Shares  held  directly  for the account of Quantum
Partners.

Item 7.           Identification  and  Classification  of the  Subsidiary  Which
                  Acquired the Security  Being Reported on by the Parent Holding
                  Company:

                  This Item 7 is not applicable.

Item 8.           Identification and Classification of Members of the Group:

                  This Item 8 is not applicable.

Item 9.           Notice of Dissolution of Group:

                  This Item 9 is not applicable.

<PAGE>

                                                             Page 13 of 19 Pages

Item 10.          Certification:

                  By signing below each signatory certifies that, to the best of
his/its knowledge and belief, the securities referred to above were not acquired
and  are  not  held  for the  purpose  of or with  the  effect  of  changing  or
influencing  the control of the Issuer of the  securities  and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having that purpose or effect.

<PAGE>

                                                             Page 14 of 19 Pages

                                   SIGNATURES


After  reasonable  inquiry  and to the  best of my  knowledge  and  belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Date: July 5, 2000                    QUANTUM INDUSTRIAL PARTNERS LDC

                                       By: /S/ RICHARD D. HOLAHAN,  JR.
                                           -------------------------------
                                           Richard D. Holahan, Jr.
                                           Attorney-in-Fact


Date: July 5, 2000                    QIH MANAGEMENT INVESTOR, L.P.

                                       By:      QIH Management, Inc.,
                                                its General Partner

                                                By: /S/ RICHARD D. HOLAHAN,  JR.
                                                    ---------------------------
                                                    Richard D. Holahan, Jr.
                                                    Secretary


Date: July 5, 2000                    QIH MANAGEMENT, INC.

                                       By: /S/ RICHARD D. HOLAHAN,  JR.
                                           -------------------------------
                                           Richard D. Holahan, Jr.
                                           Secretary


Date: July 5, 2000                    SOROS FUND MANAGEMENT LLC

                                       By: /S/ RICHARD D. HOLAHAN,  JR.
                                           -------------------------------
                                           Richard D. Holahan, Jr.
                                           Assistant General Counsel


Date: July 5, 2000                    GEORGE SOROS

                                       By: /S/ RICHARD D. HOLAHAN,  JR.
                                           -------------------------------
                                           Richard D. Holahan, Jr.
                                           Attorney-in-Fact

<PAGE>

                                                             Page 15 of 19 Pages


Date: July 5, 2000                    STANLEY F. DRUCKENMILLER

                                       By: /S/ RICHARD D. HOLAHAN,  JR.
                                           -------------------------------
                                           Richard D. Holahan, Jr.
                                           Attorney-in-Fact


Date:  July 5, 2000                    DUQUESNE CAPITAL MANAGEMENT, L.L.C.


                                       By: /S/ GERALD KERNER
                                           --------------------------------
                                           Gerald Kerner
                                           Managing Director


<PAGE>

                                                             Page 16 of 19 Pages

                                  EXHIBIT INDEX

                                                                        Page No.
                                                                        --------

E.             Power  of  Attorney,  dated  as of  January  27,  2000,
               granted by Mr. George Soros in 17 favor of Mr.  Michael
               C.    Neus    and    Mr.     Richard    D.     Holahan,
               Jr.....................................................        17

F.             Power  of  Attorney,  dated  as of  January  27,  2000,
               granted by Mr. Stanley F. Druckenmiller in favor of Mr.
               Michael  C.  Neus  and  Mr.  Richard  D.  Holahan,  Jr.
               .......................................................        18

G.             Power  of  Attorney,  dated  as of  January  24,  2000,
               granted by Quantum Industrial  Partners LDC in favor of
               Mr.  Michael  C.  Neus  and  Mr.  Richard  D.  Holahan,
               Jr....................................................         19





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