SIMULATIONS PLUS INC
10KSB, 1999-12-14
COMPUTER INTEGRATED SYSTEMS DESIGN
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 10-KSB

[x]  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

      For the fiscal year ended August 31, 1999 or

[ ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1937

      For the transition period from _________ to _________

                        Commission file number: 000-21665

                             SIMULATIONS PLUS, INC.
             (Exact name of registrant as specified in its charter)

                                   CALIFORNIA
         (State or other jurisdiction of Incorporation or Organization)

                                   95-4595609
                      (I.R.S. Employer identification No.)

                                1220 W. AVENUE J
                               LANCASTER, CA 93534
           (Address of principal executive offices including zip code)

                                 (661) 723-7723
              (Registrant's telephone number, including area code)

        SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT: NONE.

           SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE ACT:
                    COMMON STOCK, PAR VALUE $0.001 PER SHARE

         Indicate by check mark whether the registrant: (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.
                         Yes  __x__             No _____

         Check if disclosure of delinquent filers pursuant to Item 405 of
Regulation S-B is not contained herein, and will not be contained, to the best
of registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-KSB or any amendment to
this Form 10-KSB. [ ]

         The issuer's revenues for the fiscal year ended August 31, 1999 were
approximately $3,467,000.

         As of December 9, 1999, the aggregate market value of the voting stock
held by non-affiliates of the issuer was approximately $2,731,000 based upon the
average closing bid and asked price of such stock on such date.

                       DOCUMENTS INCORPORATED BY REFERENCE

         Portions of the Registrant's definitive Proxy Statement relating to the
2000 Annual Meeting of shareholders are incorporated herein by reference into
Part III.


<PAGE>

                             SIMULATIONS PLUS, INC.
                                   FORM 10-KSB
                    FOR THE FISCAL YEAR ENDED AUGUST 31, 1999

Table of Contents

                                                                            Page
                                                                            ----
PART I.

Item 1.  Description of Business                                             1

Item 2.  Description of Property                                             12

Item 3.  Legal Proceedings                                                   12

Item 4.  Submission of Matters to a Vote of Security Holders                 12


PART II.

Item 5.  Market for Common Stock and Related Stockholder Matters             13

Item 6.  Management's Discussion and Analysis or Plan of Operation           14

Item 7.  Financial Statements                                                20

Item 8.  Changes in and Disagreements with Accountants on
                  Accounting and Financial Disclosure                        20

PART III.

Item 9.  Directors, Executive Officers, Promoters and Control Persons:
                  Compliance with Section 16(a) of the Exchange Act          21

Item 10. Executive Compensation                                              21

Item 11. Security Ownership of Certain Beneficial Owners and Management      21

Item 12. Certain Relationships and Related Transactions                      21

Item 13. Exhibits and Reports on Form 8-K                                    22

           Signatures                                                        24


<PAGE>


Forward-Looking Statements

         The following discussion should be read in conjunction with the
financial statements and the notes thereto appearing elsewhere in this Annual
Report ("Annual Report") on Form 10-KSB for the year ended August 31, 1999 (the
"Form 10-KSB"). In addition to historical information, this Annual Report
contains forward-looking statements. The forward-looking statements contained
herein are subject to certain risks and uncertainties that could cause actual
results to differ materially from those reflected in the forward-looking
statements. Factors that might cause such a difference include, but are not
limited to, those discussed in the section entitled "Management's Discussion and
Analysis or Plan of Operation." Readers are cautioned not to place undue
reliance on these forward-looking statements, which reflect management's
analysis only as of the date hereof. Simulations Plus, Inc. undertakes no
obligation to publicly revise these forward-looking statements, or to reflect
events or circumstances that arise after the date hereof. Readers should
carefully review the risk factors described in other documents the Company has
filed and will continue to file from time to time with the Securities and
Exchange Commission.


                                     PART I

                         ITEM 1. DESCRIPTION OF BUSINESS

GENERAL
================================================================================

         Simulations Plus, Inc. (the "Company" or "Simulations Plus") and its
wholly owned subsidiary, Words+, Inc. ("Words+") produce two types of products:
(1) Simulations Plus, formed in 1996, develops and produces simulation software
for use in pharmaceutical research and for education, and also provides contract
research services to the pharmaceutical industry, and (2) Words+, founded in
1981, produces computer software and specialized hardware for use by persons
with disabilities, as well as a personal productivity software program called
Abbreviate! for the retail market.

DESCRIPTION OF SIMULATION SOFTWARE
         The types of simulation software produced by the Company are based on
the equations of chemistry and physics that describe or "model" the behavior of
things in the real world. The Company's GastroPlus(TM) pharmaceutical software
simulates the movement, dissolution, absorption, and clearance of drug compounds
in the human gastrointestinal tract. The Company's QMPRPlus(TM) program
estimates the value of several important physicochemical characteristics of new
drug-like molecules with only the structure of the molecule as input. The
Company's award-winning FutureLab(TM) science experiment simulations for middle
school and high school students incorporate the equations of chemistry and
physics for each experiment (optics, electrical circuits, gravity, ideal gases,
acid/base titration, etc).

         The development of simulation software involves identifying and
understanding the underlying chemistry and physics of the processes to be
simulated, breaking those processes down into the lowest practical level of
individual sub-processes at which the behaviors can be well-represented
mathematically, developing appropriate mathematical relationships/equations, and
converting them into computer subroutines. The software subroutines representing
these individual processes are then assembled into an overall simulation
program, with appropriate coordination between modules and design of
user-friendly inputs and outputs. The predictions of this program are then
compared to known results in order to determine the validity of the model and to
calibrate the simulation to produce a useful tool for predicting new results.

                                       1
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PHARMACEUTICAL SIMULATION SOFTWARE
================================================================================

PRODUCTS:
         The Company's pharmaceutical software provides cost-effective solutions
to a number of problems in pharmaceutical research as well as in the education
of pharmacy and medical students. The Company's software products and services
to date are focussed on the area of pharmaceutical research known as ADME
(Absorption, Distribution, Metabolism, and Excretion). In August 1998, the
Company released its first product GastroPlus(TM), which incorporates an
absorption model that runs under Windows NT(TM), Windows 95(TM), or Windows
98(TM). The program includes a variety of specialized analysis functions in
addition to the basic absorption and pharmacokinetics simulation. The Parameter
Sensitivity Analysis feature allows researcher to rapidly assess the importance
of various physicochemical and formulation variables on the absorption and
pharmacokinetic behavior of a drug. The Stochastic Simulation feature allows
researchers to model the effects of statistically distributed values for a
variety of physiological and other parameters over a large population.

         Sales of GastroPlus(TM) began in late August and early September 1998,
with sales to large pharmaceutical companies such as Astra-Zeneca, Pfizer,
Pharmaceia and Upjohn, The Roche Group, and SmithKline Beecham. An additional
(extra-cost) Optimization Module was released in November 1998 and is receiving
enthusiastic interest from pharmaceutical researchers, with the majority of new
sales now including this module. The second optional module, IVIV Correlation,
has taken longer than expected to develop; however, it is now in an advanced
stage in development and is expected to be released in early 2000. Two other
modules are also in development, and both are expected to be released in mid
2000. These extra-cost modules may increase the average sale price for an annual
license. The Company is actively working over 50 leads for additional sales.

         The Company executed a License Agreement with Therapeutic Systems
Research Laboratories, Inc. ("TSRL"), under which the Company was granted
exclusive rights to TSRL's proprietary absorption simulation technology,
including a database of measurements of drug permeability from nearly 60
laboratory experiments to measure the intestinal permeability of drug compounds
in human and/or rat small intestines. The Company is also receiving consulting
assistance in the development of the simulation model from TSRL staff, including
Dr. Gordon Amidon (past President of the American Association of Pharmaceutical
Scientists and world-renowned expert in drug absorption) and Dr. John Crison.
The Company believes that the strategic advantage of exclusive access to TSRL's
technology and expertise in absorption modeling, combined with the Company's now
well-developed and growing expertise in absorption and pharmacokinetics
simulation, have resulted in GastroPlus(TM) becoming recognized as a unique
simulation and analysis capability within the pharmaceutical industry. The
Company is aware that other companies began to develop similar software,
however, there has not been any significant direct competition for
GastroPlus(TM) at this time.

         The Company has developed and is now selling a companion program to
GastroPlus(TM) called QMPRPlus(TM) (Quantitative Molecular Permeability
Relationships). QMPRPlus(TM) takes as inputs the structures of molecules, and
provides estimates for human effective permeability, octanol-water partition
coefficient (logP), solubility, and diffusivity - all inputs required by
GastroPlus(TM). QMPRPlus(TM) thereby extends the utility of GastroPlus(TM) into
early drug discovery, during which pharmaceutical companies may not have even
made many of the molecules that have been identified as potential drug
candidates. By providing estimates of physicochemical properties from structure
alone, QMPRPlus(TM) coupled with GastroPlus(TM) allows researchers to rank order
large numbers of candidate compounds in terms of human intestinal absorption.
Those identified as having good absorption can be given high priority in the
dedication of resources for synthesis and experimental testing, while those with
low predicted absorption can be given lower priority or can be eliminated.
Because pharmaceutical companies are dealing with millions of compounds per
year, and because the area of ADME has become a bottleneck, high throughput
screening on the computer ("IN SILICO") is becoming not just a convenience, but
a necessity.

                                       2
<PAGE>

         The Company continues to develop the science of simulation and
mathematical modeling for ADME-related research, and to add new and improved
features to its software products to make them ever more powerful and vital to
the pharmaceutical industry. Among the Company's goals in this area are to
provide comprehensive, highly accurate simulations as well as related software
and services that can save a great deal of time and money in the development of
pharmaceutical products, and to reduce the need for animal testing in the
future.

CONTRACT RESEARCH SERVICES:
         The Company offers contract research services to the pharmaceutical
industry in the area of gastrointestinal absorption and related technologies.
The Company received two study contracts in the first quarter of FY 1999 (the
fiscal year ended August 31, 1999) from major pharmaceutical companies. An
additional larger study contract was received from one of these customers in the
second quarter. These contracts mark the beginning of a new source of revenues
for the Company, as well as a means to introduce the Company's software products
to new customers (both companies purchased GastroPlus(TM) after their initial
study contracts were completed). Management expects the number and size of study
contracts, which can include custom software development, to continue to
increase during the new fiscal year.

PRODUCT DEVELOPMENT:
         In the area of simulation software for pharmaceutical research, the
Company is currently pursuing the development of additional modules for
GastroPlus(TM) and a companion program called QMPRPlus(TM), as well as
HelixGen(TM) -- software to predict the receptor structure of certain
transmembrane proteins.

IVIV Correlation Module
- -----------------------
         The IVIV Correlation Module, currently in development, provides IN
VITRO-IN VIVO correlation capabilities to pharmaceutical researchers. IN
VITRO-IN VIVO correlation in this context refers to the ability to determine the
relationship between the concentration-time curve of a drug product in the blood
after an oral dose (IN VIVO) to the rate at which the oral dose is observed to
dissolve in a laboratory experiment (IN VITRO). The IVIV Correlation module will
also provide a means for pharmaceutical researchers to solve for the values of
certain important pharmacokinetic parameters from blood concentration-time data
taken after an intravenous injection or infusion of a drug product. The IVIV
Correlation Module is expected to be released during the second quarter of FY
2000.

QMPRPlus(TM)
- ------------
         The first version of QMPRPlus(TM) loaded data in the form of
2-dimensional structures; however, the Company has recently added 3-dimensional
structures and is expected to release a new version early in the second quarter
of FY2000. The molecular descriptors in the first version included less than 30
descriptors, while the upcoming release now calculates nearly 150 descriptors.
The mathematical models now include more powerful artificial neural network
(ANN) models for logP and solubility.

Absorption Systems Caco-2 Permeability Module
- ---------------------------------------------
         The Company is also developing an optional module for QMPRPlus(TM) to
predict permeability from data collected IN VITRO in Caco-2 cells. The Company
signed a license agreement with Absorption Systems LP of Exton, Pennsylvania,
for data on 330 compounds tested by Absorption Systems in Caco-2 cell cultures,
and is using this database to build the optional module, which is expected to be
released in the second quarter of FY2000.

                                       3
<PAGE>

Metabolism and Efflux Module
- ----------------------------
         The Metabolism and Efflux Module will extend the simulation within
GastroPlus(TM) to include greater detail for the effects of certain metabolic
processes on drug molecules, and the effects of certain proteins in intestinal
cells that return ("efflux") a drug molecule to the intestinal contents.
Metabolism refers to the action of certain enzymes, present within the
intestinal cells, the blood, and in the liver, that change a drug molecule
either by cleaving part of it away or by adding other atoms to it. This effect
usually renders a drug molecule ineffective, but sometimes can turn a molecule
into a useful drug product after the original molecule (in this case called a
"prodrug") has been absorbed. Efflux refers to a process wherein a drug molecule
enters an intestinal cell, but is later returned to the interior of the
intestine by an efflux protein. Both metabolism and efflux are important
processes for certain types of drug molecules, so there is considerable interest
within the pharmaceutical industry in modeling (simulating) the mechanisms by
which these processes occur during and subsequent to intestinal absorption of
the drug molecules. The Company expects to release the Metabolism and Efflux
Module during the second quarter of fiscal year 2000.

HelixGen(TM)
- ------------
         HelixGen(TM) is a program that predicts the 3-dimensional geometry
(i.e., the position of each atom) of a special class of proteins known as
G-coupled transmembrane proteins. This type of protein serves as a channel for
passage of certain molecules through the walls of nerve cells and other cells,
and is a target for the majority of neurogenic drugs. Drugs that bind to these
sites can prevent the flow of molecules into and out of the cell, and in so
doing may relieve pain, reduce tremors, improve memory, or other such
nerve-related functions. The ability to predict the geometry of these proteins
will enable researchers to identify likely new drug molecules that could bind to
these sites in the computer, prior to actually synthesizing molecules for
experimental testing. Development of HelixGen was largely postponed in order to
focus on GastroPlus(TM) and QMPRPlus(TM). Full development of the program is
expected to resume in early FY 2000.

MARKETING AND DISTRIBUTION:
         The Company markets its pharmaceutical simulation software products,
and research services based on its simulations, to pharmaceutical and biotech
companies, and to the research companies that serve them, through attendance and
presentations at scientific meetings, exhibits at trade shows, seminars at
pharmaceutical companies and government agencies, advertising in selected
publications, and through its web pages on the Internet. The Company is building
an in-house sales and marketing team for its products and services and will also
explore sales and marketing agreements with firms that provide research services
and equipment that are complementary to the Company's existing and proposed
(i.e., in development) pharmaceutical products and services. The Company also
uses its web pages on the Internet for such activities as providing product
information, providing software updates, and as a forum for user feedback and
information exchange. The Company will also explore distribution through
university bookstores for the Academic version of GastroPlus(TM) for students in
pharmacy and medicine.

         In August 1998, The Company signed a distribution agreement with Teijin
Systems Technology Ltd. (TST), a division of Teijin Limited of Tokyo, Japan.
Under the terms of the agreement, TST received exclusive distribution rights to
Simulations Plus' GastroPlus(TM) and QMPRPlus(TM) software for pharmaceutical
research and education in Japan.

PRODUCTION:
         The Company's major products are designed and developed by its
development team at its Lancaster, California facility. The chief materials and
components used in simulation software products include CD-ROMs and instruction
books. CD-ROM production is performed in-house for low-volume products, and is
contracted to third parties for high volume products.


                                       4
<PAGE>

COMPETITION:
         In providing simulation-software-based screening, testing and research
services to the pharmaceutical industry, and in marketing simulation software
for these purposes, the Company competes against a number of established
companies that provide screening, testing and research services and products to
these industries that are not based on simulation software. The Company's
competitors in this field include companies with financial, personnel, research
and marketing resources that are greater than those of the Company. While there
is currently no significantly competitive product to GastroPlus(TM) or
QMPRPlus(TM), competition can be expected at some time in the future.

         Major pharmaceutical companies conduct these efforts through their
internal development staffs and through outsourcing some of this work. Smaller
companies need to outsource a greater percentage of this research. The Company
is aware of a few other companies that are presently developing simulation
software or simulation-software-based services to the pharmaceutical industries
for the purposes of screening compounds, but is not aware of the development of
any directly competitive software to GastroPlus(TM) or QMPRPlus(TM).

         The Company is not aware of any significant competition in the area of
gastrointestinal absorption simulation. The Company is aware of one company in
England that produces animation software for education in pharmacy and medicine,
but is not aware of any commercial effort by any company to produce and sell a
gastrointestinal absorption simulation program for pharmaceutical research. The
Company is aware of one other company called Trega (with a subsidiary called
Navicyte) that is developing an absorption simulation, but information obtained
by the Company indicates that this simulation is not a product for sale, but
rather is incorporated into larger development efforts as part of a consortium
approach. Information obtained by the Company indicates that Navicyte has five
customers, of which three have since licensed GastroPlus(TM).

         The Company believes the key factors in competing in this field are its
ability to develop simulation software and related products and services to
effectively predict the ADME-related behaviors of new drug-like compounds, its
ability to develop and maintain a proprietary database of results of physical
experiments that will serve as a basis for simulated studies, and its ability to
develop and maintain relationships with research and development departments of
pharmaceutical companies and government agencies. There can be no assurances
that the Company will be successful in providing these key factors.




EDUCATIONAL SIMULATION SOFTWARE
================================================================================

PRODUCTS:
         The Company's initial educational software products, which have won
awards from educational software testers, include simulations of laboratory
experiments for Physical Science and Chemistry courses under the umbrella name
FutureLab(TM). The Company released its first three FutureLab(TM) titles in May
1997 (OPTICS FOR PHYSICAL SCIENCE, GRAVITY FOR PHYSICAL SCIENCE, and CIRCUITS
FOR PHYSICAL SCIENCE), and a new title, IDEAL GAS FOR CHEMISTRY in November
1997, all for Windows-based computers. In August 1998, after a conversion effort
that took over one year for some labs, the Company released new versions of all
of these titles as well as UNIVERSAL GRAVITATION FOR PHYSICAL SCIENCE for both
Windows and Macintosh computers. Macintosh computers account for 40-50% of the
educational market. An additional educational simulation, TITRATION FOR
CHEMISTRY, was released in September 1999.

                                       5
<PAGE>

         FutureLab(TM) educational software programs simulate science
experiments for high school and college level science and engineering classes.
These simulations enable students to conduct experiments on a personal computer
instead of in a traditional laboratory, thereby increasing safety, decreasing
costs, and providing expanded learning opportunities by allowing simulations of
situations not possible in a traditional laboratory environment. FutureLab(TM)
software has received recognition from Computers in Physics magazine, which
declared it a winner in its Eighth Annual Software Contest, as well as from two
educational institutions who perform rigorous educational software evaluation.

PRODUCT DEVELOPMENT:
         In the area of educational simulations, the Company decided to freeze
R&D activities after finishing the latest title, TITRATION FOR CHEMISTRY.
Current sales and the remainder of a grant from National Science Foundation
could not provide support for continued development of educational software.

MARKETING AND DISTRIBUTION:
         The Company markets its science experiment simulation software products
through software resellers and its Internet web page. As of August 1998, the
Company has reduced its marketing efforts in this area in order to concentrate
more of its resources on the pharmaceutical software market. The Company is
relying on its resellers to provide the majority of the marketing and sales
efforts for its educational software products. FutureLab Sales have continued
through these distributors.

PRODUCTION:
         The Company's educational software products were designed and developed
by its development team at its Lancaster, California facility. The Company
contracts the production of CD-ROMs to third parties for high volume products
and low-volume production is performed in-house. The chief materials and
components used in simulation software products include CD-ROMs and instruction
books.

COMPETITION:
         The educational software industry in which the Company operates is
competitive. The Company competes against publishers and suppliers of textbook
educational materials that have been, and will continue to be, the primary
educational resource used in these markets. The Company also competes against
educational software publishers who provide software products that are
interactive but most are not true simulation software. Most education software
publishers compete in the grades below 9th grade, addressing primarily reading
and math skills. The Company competes primarily in the middle school, high
school, and college markets addressing primarily science and math subjects. A
smaller number of software publishers are addressing these markets, although
existing competitors may broaden their product lines to these markets, and
additional competitors may enter these markets.

         The Company is aware of several companies publishing various types of
educational simulation software including HyperCube, Glencore, Corel, Logal
Educational Software and Systems, and Knowledge Revolution. Logal is the only
company of which the Company is currently aware that is producing a range of
educational simulation software that competes directly with the Company's
current and planned educational simulation software products. The Company
expects that high school and college science and math textbook publishers and
other companies may also be developing simulation software products and that
additional competitors may enter this field. Information gathered by the Company
at conferences for science teachers and school administrators indicates that
these customers and potential customers prefer the Company's products over those
offered by Logal almost unanimously, for those titles which have been released
by the Company to date.


                                       6
<PAGE>


DISABILITY PRODUCTS
================================================================================

PRODUCTS:
         The Company's wholly owned subsidiary, Words+, Inc. has been in
business since 1981. Words+ is a technology leader in designing and developing
augmentative and alternative communication computer software and hardware
devices for persons who cannot speak due to physical disabilities. Words+ also
produces computer access products that enable physically disabled persons to
operate a computer. Words+ products enable a disabled person to operate a
computer and to communicate through a voice synthesizer, through movements as
slight as the blink of an eye. Words+ developed and produces the software for
the computerized communication system used by the world-famous theoretical
physicist, Professor Stephen Hawking, Lucasian Professor of Mathematics at the
University of Cambridge in England, and the author of the best-selling book A
BRIEF HISTORY OF TIME. Words+ markets its products throughout the United States
and to other countries through a direct sales staff and independent dealers.
Words+ introduced a fully integrated, portable, lightweight
personal-computer-based communication system that is meeting favorable market
acceptance.

E Z Keys for Windows(TM)
- ------------------------
         One of the Company's primary software products is E Z KEYS FOR WINDOWS
("E Z KEYS(TM)"), which is a program that operates on a Windows-based personal
computer. When coupled with specially-designed input devices, E Z KEYS enables
even severely disabled persons to operate a personal computer, to generate voice
messages through a voice synthesizer, and to operate most Windows-based software
application programs. Input motion by the user can be as slight as the blink of
an eye, or simple eye movement by persons who cannot blink. E Z KEYS is one of
the two Words+ programs used by Professor Stephen Hawking for computer access
and communication. In May 1997, the Company released E Z KEYS FOR WINDOWS 95,
the current version of which is also compatible with Windows 98.

Talking Screen for Windows(TM)
- ------------------------------
         TALKING SCREEN FOR WINDOWS ("TALKING SCREEN(TM)") is a software program
that operates on a Windows-based personal computer and is designed for persons,
usually children, who cannot read and write at the level necessary to adequately
operate E Z KEYS. TALKING SCREEN provides a system of pages of pictographic and
photographic symbols by which the user can produce speech output messages
through a voice synthesizer, play recorded sounds and video files, and operate
controllers for lights, electrical appliances and other equipment. Like E Z
KEYS, TALKING SCREEN can be operated through a wide range of alternative input
devices.

Freedom 2000
- ------------
         Words+ released a new communication system called Freedom 2000 in
February 1998. It allows persons with disabilities who read at a second-grade
level and above to speak and write through alternative input methods (rather
than traditional keyboard and mouse). Freedom 2000 with E Z KEYS gives the users
the ability not only to speak and write, but also to play games and control
various items in their environment, such as TV's and telephones. High level
users are also able to deliver lectures to large groups, use the Internet, and
send e-mail. New orders for Words+ products in FY99 were at record levels and
Freedom 2000 orders constitute a significant portion of these new orders. A
lighter weight version of the Freedom 2000, called Freedom 2000 LITE, was
introduced in October 1998. Although it has a smaller display, the 4.0 lb
Freedom 2000 LITE is more attractive to ambulatory users than the 8.0 lb Freedom
2000.

                                       7
<PAGE>

MessageMate
- -----------
         The Company produces a series of products called MessageMates, which
are hand-held, dedicated communication devices that store recorded speech or
sound on integrated circuit chips. The user plays these recorded sounds by
touching one of the keys on the membrane keyboard if they are able to use a
keyboard, or by using a switch (such as the IST Switch described below) and
scanning to select a position on the keyboard. MessageMates are small,
lightweight (1 to 1.75 lbs.), easy-to-use communication devices with up to ten
minutes of recorded messages. They are known for their extremely rugged design
and long battery life. The MessageMate 20 holds twenty messages, the MessageMate
40 holds forty messages, and the Mini-MessageMate holds eight messages. Since
MessageMates use recorded messages, they can be used in any language. The
Company has significant sales of MessageMate in foreign markets and sales of
MessageMates in foreign markets are increasing.

Infrared/Sound/Touch (IST) Switch
- ---------------------------------
         Many Words+ customers cannot operate a keyboard or mouse. For some of
these persons, the Company has designed and produces a special device called the
Infrared/Sound/Touch Switch ("IST Switch"), that enables the person to operate a
personal computer or a dedicated communication device with the slightest
movement or pressure, including, for example, eye blink, or just eye movement.
The IST is activated by infrared reflection, touch, or sound, and transmits a
momentary "on" signal to the computer upon detecting these signals. This switch
has been in production in ever-improving forms since 1983, and thousands of
physically disabled persons around the world have used it.

Miscellaneous
- -------------
         Words+ also sells a number of other miscellaneous and peripheral
devices, some of which it designs and produces and others it buys and resells.
These include:

         o    Micro CommPac - Communication hardware package designed for use
              with a notebook computer that provides switch interface and audio
              amplification.
         o    U-Control - Wireless infrared remote control device that allows
              the user to control functions and appliances in the home and work
              environment such as lights, stereo and television equipment, and
              other appliances.
         o    Simplicity Wheelchair Mount - Company-designed and produced
              wheelchair mount for portable computers and other devices.

PRODUCT DEVELOPMENT:
         The Company believes it has been an industry technology leader in
introducing and improving augmentative and alternative communication and
computer access software and devices for disabled persons and intends to
continue to be at the forefront of the development of new products. The Company
will continue to enhance its major software products, E Z KEYS and TALKING
SCREEN, as well as its growing line of hardware products. The Company will also
consider acquisitions of other products, businesses and companies that are
complementary to its existing augmentative and alternative communication and
computer access business lines.

         The Company is currently developing a new Message Builder feature for
the MessageMate, which is an enhancement of the existing MessageMate product. It
enables users to select prerecorded words or phrases one at a time, and then
play the entire message formed by them. The Company expects to release this new
version in the second quarter of FY 2000.

MARKETING AND DISTRIBUTION:
         The Company markets augmentative and alternative communication products
through a network of employee representatives and independent dealers.

         At the present time the Company has seven independent dealers in the
U.S., four in Australia and one each in Canada, England, Norway, The
Netherlands, New Zealand, Japan, Finland and Malaysia. The Company also has
three salary-commission sales persons in the U.S.: one each in Southern
California, Maine, and Maryland, and the Company employs four inside
sales/support persons who answer telephone inquiries on the Company's 800 line
and who provide technical support. Additional outside sales persons are being
actively recruited at this time.

                                       8
<PAGE>

         The Company directs its marketing efforts to speech pathologists,
occupational therapists, special education teachers, disabled persons and
relatives of disabled persons. The Company maintains a mailing list of over
37,000 persons made up of these professionals, consumers and relatives and mails
various marketing materials to this list. These materials include the Company's
catalog of products and announcements regarding new and enhanced products.

         The Company participates in industry conferences held throughout the
U.S. and in other countries that are attended by speech pathologists,
occupational and physical therapists, special education teachers, parents and
consumers. The Company and others in the industry demonstrate their products at
these conferences and present technical papers that describe the application of
their technologies and research studies on the effectiveness of their products.
The Communication Aids Manufacturers Association (CAMA) organizes tours of
representatives of companies in this field that travel throughout the country
providing seminars and workshops for professionals, consumers and parents in the
field. The Company advertises in selected publications of interest to persons in
this market.

         The Company estimates that for approximately 50% of its sales of
augmentative and alternative communication software and hardware, some or all of
the purchase price is provided by third parties such as Medicaid, school special
education budgets, private insurance or other governmental or charitable
assistance. The Company's personnel provide advice and assistance to customers
and prospective customers on obtaining third-party financial assistance for
purchasing the Company's products. No assurances can be given that such third
party support will continue to be available for the purchase of the Company's
products.

PRODUCTION:
         Disability software products are either loaded onto hard drives by the
Company or copied to diskettes or CD-ROM, which is contracted to third parties
for high-volume production and is performed in-house for low-volume production.
Microprocessors that are part of dedicated devices are purchased by the Company
and incorporated into its products by the Company. Many software customers buy
their notebook personal computers from the Company, which the Company purchases
at wholesale prices and resells at a markup. Cases, printed circuit boards,
labels and other components of products such as MessageMate and CommPac are
designed by the Company. The Company outsources the extrusion, machining and
manufacturing of certain components. All final assembly and testing are done by
the Company at its facility.

         The Company's products are shipped from its Lancaster, California
facility either directly to the customer or to the salesperson or dealer. The
outside salesperson or dealer either delivers the product or visits the customer
after delivery to provide training.

COMPETITION:
         The augmentative and alternative communication industry in which the
Company operates is highly competitive and some of the Company's competitors
have greater financial and personnel resources than the Company. The industry is
made up of six major competitors including the Company, and a number of smaller
ones. The Company believes that the five other major competitors each have
revenues ranging from $3 Million to $20 Million so that there are no large
companies in this industry. Two of these companies primarily produce
personal-computer-based software systems for Apple Macintosh and the others
produce dedicated communication devices and/or paper products.

                                       9
<PAGE>

         The Company believes that the competition in this industry is based
primarily on the quality of products, quality of customer training and technical
support, and quality and size of sales forces. Price is a competitive factor but
the Company believes price is not as important to the customer as obtaining the
product most suited to the customer along with strong after-sale support. The
Company believes that it is a leader in the industry in developing and producing
the most technologically advanced products and in providing quality customer
training and technical support. The prices of the Company's products are among
the highest in the industry and the Company has one of the smallest sales forces
and dealer networks in the industry. The Company believes it is positioned to
continue to be a leader in the development and production of the highest quality
technology and that it will be able to develop one of the strongest sales forces
in the industry by increasing the number of sales representatives or
distributors. The Company believes that the sales of its products can increase
significantly due to these factors and the expected continuing expansion of the
size of this market. However, there are few barriers to entry in the form of
proprietary or patented technology or trade secrets in this industry. While the
Company believes that cost of product development and the need for specialized
knowledge and experience in this industry would present some deterrence for new
competition, other companies may enter this industry, including companies with
substantially greater financial resources than the Company. Furthermore,
companies already in this industry may increase their market share through
increased technology development and marketing efforts.


PERSONAL PRODUCTIVITY SOFTWARE
================================================================================

PRODUCT - ABBREVIATE!:
         Words+ released a productivity software program called ABBREVIATE! in
November 1997 at COMDEX. The Company extracted the abbreviation technology
incorporated into the E Z KEYS FOR WINDOWS software used by Professor Stephen
Hawking and thousands of others around the world, and turned it into a program
that can be used by anyone with the ability to use a standard keyboard. While
many word processors provide a similar "Quick Correct" feature, the advantage
ABBREVIATE! has over such features is that it runs in the background and works
with almost all Windows applications. Thus, ABBREVIATE! allows the user to
create a personal library of frequently-used abbreviations, each with its own
special keystroke combination, for use in virtually any Windows-based program,
e.g., fax, e-mail, word processing, database, Internet chat rooms, and
spreadsheets. The Company is currently pursuing distribution relationships with
a number of major software manufacturers for ABBREVIATE!. Abbreviate! was named
PC Week magazine's "Tool of the Week" in their December 1, 1997 issue, and won
Win95 magazine's Editor's Choice Award in March 1998.

MARKETING AND DISTRIBUTION:
         The Company is currently selling the program itself through a variety
of Internet channels, including its own web site (www.abbreviate.com), and
through distributors. The Company is also contacting large software
manufacturers and distributors in an effort to secure distribution agreements
for ABBREVIATE!. While sales have been constant at a low level, no assurance can
be given as to whether this product will be successful.

PRODUCTION AND DISTRIBUTION:
         THE ABBREVIATE! personal productivity software program is currently
manufactured at the Company's Lancaster, California facility. If sales volume
warrants and higher volume capacity is required, the Company will investigate
outside sources for fulfillment.

COMPETITION:
         A few products compete with ABBREVIATE! in the retail market; however,
the Company is not aware of any other product that works with virtually any
software in Windows 95/98 without the need to create special links to the
software. A version for Windows NT is expected to be released in the second
quarter of FY2000. The Company has priced ABBREVIATE! significantly less than
competitors SmarType and InstantText. The Company enlisted the help of several
medical transcriptionists as beta testers for the product, and the feedback
received from those testers and additional medical transcriptionists, who are
familiar with competitive products, has been very favorable.

                                       10
<PAGE>

TRAINING AND TECHNICAL SUPPORT
================================================================================

         The Company believes customer training and technical support are
important factors in customer satisfaction for its pharmaceutical and disability
products and the Company believes it is an industry leader in providing customer
training and technical support. For pharmaceutical software, the Company
provides in-house seminars at the customer's site to demonstrate GastroPlus(TM)
and QMPRPlus(TM). During FY 1998 and 1999, the company delivered such seminars
in seveRAl locations around the U.S. and in Japan. The Company has delivered a
series of seminars in Japan to over 150 scientists from over 40 different
companies. The Company also conducted on-site seminars at approximately 55
pharmaceutical and related research companies in the U.S. and Europe. These
seminars serve as initial training in the event the potential customer decides
to license the software. Strong technical support is provided after the sale in
the form of in-house training at customer's cost, telephone, fax, and e-mail
assistance to users, as well as an ongoing process of software upgrades to
ensure the product remains at the cutting edge of technology. Software licenses
are on an annual basis, and include all upgrades to the modules licensed by the
customer during the license year.

         For Disability Products, the Company's salesperson or dealer provides
initial training to the customer -- typically two to four hours on major
products and one to two hours on certain other products. This training is
typically provided not only to the user of the product but also to the person's
speech pathologists, teachers, parents and others who will be helping the user.
This initial training is provided as a part of the price of the product. The
Company and its dealers charge a fee for additional training and service calls.

         Technical support for both Simulation Software and Disability Products
is provided by the Company's inside sales and support staff based at its
headquarters facilities in Lancaster, California. The Company provides no-charge
toll telephone support offering unlimited toll-free numbers and E-mail support
for all of its simulation software and disability products.


EMPLOYEES
================================================================================

         As of August 31, 1999, the Company employed 32 full-time and 2
part-time employees, including 6 in research and development, 7 in marketing and
sales, 12 in administration and accounting, 8 in production and 1 in repair.
Three current employees hold Ph.D.'s in their respective science or engineering
disciplines and four additional employees hold Master's degrees. The Company
believes that its future success will depend, in part, on its ability to
continue to attract, hire and retain qualified personnel. The competition for
such personnel in the augmentative and alternative communication device and
computer software industry is intense. None of the Company's employees is
represented by a labor union, and the Company has never experienced a work
stoppage. The Company believes that its relations with its employees are good.

         In August 1998 the Company decided to focus on pharmaceutical software
and to minimize educational software development. A layoff of a number of
educational software developers, and temporary salary reductions for senior
management, were instituted in order to protect the assets of shareholders by
reducing expenses.


                                       11
<PAGE>

                        ITEM 2. DESCRIPTION OF PROPERTIES

         The Company moved its office location from Palmdale, California to
Lancaster, California in July 1998, expanding its office space from
approximately 11,800 square feet to approximately 15,600 square feet. The lease
on the office space currently occupied by the Company will expire in August
2001. The Company realized a savings of approximately $40,000 per year through
the lease it negotiated on this new property.


                            ITEM 3. LEGAL PROCEEDINGS

         The Company is not a party to any significant litigation and is not
aware of any significant pending or threatened litigation against the Company.


           ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS


         No matters were submitted to a vote of security holders during the
fourth quarter of fiscal 1999.


                                       12
<PAGE>

                                     PART II

         ITEM 5. MARKET FOR COMMON STOCK AND RELATED STOCKHOLDER MATTERS

         The Company's Common Stock began trading on the Nasdaq SmallCap Market
("Nasdaq") on June 18, 1997 under the symbol "SIMU". At the closing on July 2,
1999, the Company's Common Stock was delisted from Nasdaq and is currently
exchanged on the OTC Bulletin Board. According to records of the Company's
transfer agent, the Company had at least 18 stockholders of record and 818
beneficial owners as of August 31, 1999. The following table sets forth the low
and high sale prices for the Common Stock as reported by Nasdaq and subsequent
to delisting on the OTC or each of the last two fiscal years.
<TABLE>
<CAPTION>

                                                                             LOW SALES PRICE   HIGH SALES PRICE
                                                                             ---------------   ----------------
         <S>                                                                      <C>               <C>
         Fiscal 1999:
                  Quarter ended August 31, 1999....................               1.500             2.750

                  Quarter ended May 31, 1999.......................               2.375             3.750

                  Quarter ended February 28, 1999..................               0.875             4.000

                  Quarter ended November 30, 1998..................               1.000             2.375

         Fiscal 1998:
                  Quarter ended August 31, 1998....................               1.500             5.250

                  Quarter ended May 31, 1998.......................               3.500             7.375

                  Quarter ended February 28, 1998..................               4.250             8.500

                  Quarter ended November 30, 1997..................               5.000             5.750

</TABLE>


                                       13
<PAGE>


ITEM 6. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

RESULTS OF OPERATIONS

         The following sets forth selected items from the Company's statements
of operations (in thousands) and the percentages that such items bear to net
sales for the fiscal years ended August 31, 1999 ("FY99"), August 31, 1998
("FY98") and August 31, 1997 ("FY97").

<TABLE>
<CAPTION>


                                                                           Year Ended August 31,
                                                     ---------------------------------------------------------------------
                                                            1999                     1998                     1997
                                                     -------------------      --------------------     -------------------
   <S>                                               <C>         <C>          <C>          <C>         <C>         <C>
   Net sales                                         $3,467      100.0%       $2,645       100.0%      $2,493      100.0%
   Cost of sales                                      1,649        47.6        1,756         66.4       1,252        50.2
   Gross Profit                                       1,818        52.4          889         33.6       1,241        49.8
   Selling, general, and administrative               2,308        66.6        2,683        101.4       2,277        91.3
   Research and development                             219         6.3          390         14.7         133         5.4
   Total operating expenses                           2,527        72.9        3,073        116.1       2,410        96.7
   Income (loss) from operations                       (709)      (20.4)      (2,184)       (82.5)     (1,169)      (46.9)
   Income from grant                                    150         4.3          150          5.7          17         0.7
   Interest income                                        5         0.1           58          2.2          26         1.0
   Interest expense                                      21         0.6           16          0.6          69         2.8
   Financing costs                                        -           -            -            -         280        11.2
   Loss on investment, at equity                          -           -          (75)        (2.8)          -           -
   Provision for (benefit from) income taxes              2         0.1            2          0.2         (39)       (1.6)
   Net income (loss)                                   (577)     (16.6)%      (2,069)      (78.2)%     (1,436)      (57.6)%

</TABLE>


FY99 COMPARED WITH FY98
================================================================================

NET SALES
- ---------
         Net sales for FY99 increased by $822,000 or 31.1%, to $3,467,000
compared to $2,645,000 for FY98. Simulations Plus, Inc.'s sales from
Pharmaceutical and educational software increased approximately $400,000, or
655.7%, and Words+, Inc.'s sales increased approximately $422,000, or 16.3% for
the year. Management attributes the increase in consolidated net sales to the
first sales from Pharmaceutical software launched in FY99, and to increased
sales from Words+, Inc., its subsidiary. Pharmaceutical software sales
contributed over 45% of the total increase in consolidated sales for the year.
The increase in Words+ sales is due primarily to its Multi-Level MessageMate and
Freedom 2000 communication products being well received by the marketplace. The
Company has noticed a steady increase in Words+ orders that began in February
1998 and continues through the end of FY99; however, no assurance can be given
as to whether this trend will continue.


                                       14
<PAGE>

COST OF SALES
- -------------
         The consolidated cost of sales for FY99 decreased by $107,000 or 6.1%
to $1,649,000 from $1,756,000 in FY98. As a percentage of sales, cost of sales
was 47.6% for FY99, compared to 66.4% for FY98, indicating an 18.8% decrease.
For Simulations Plus, cost of sales decreased $87,000, or 18.0%, of which the
significant portion of cost of sales is the systematic amortization of
capitalized software development costs, which resulted in a 19.2% decrease in
amortization cost. The Company expensed $183,000 of capitalized software
development costs relating to educational software in FY99 and $350,000 in FY98.
There will be no further write off against revenue generated from the sales of
educational software from now on. For Words+, the cost of sales decreased
$20,000, or 1.6%. Management attributes the reduction in cost of sales between
FY99 and FY98 to a decline in amortization costs and labor costs, which
outweighed an increase in material and warranty costs.

GROSS PROFIT
- ------------
         The consolidated gross profit increased $929,000, or 104.5%, to
$1,818,000 in FY99 from $889,000 in FY98. Management attributes the 18.8%
increase in gross profit margin from 33.6% in FY98 to 52.4% in FY99 primarily to
the increase in net sales combined with the decline in cost of goods sold,
particularly in amortization cost.

SELLING, GENERAL AND ADMINISTRATIVE EXPENSES
- --------------------------------------------
         Selling, general and administrative expenses for FY99 decreased by
$375,000, or 14.0% to $2,308,000, compared to $2,683,000 for FY98. As a
percentage of net sales, selling, general and administrative expenses decreased
by 34.8% to 66.6% in FY99 from 101.4% in FY98. For Simulations Plus, the
selling, general and administrative expenses decreased $140,000, or 15.1%
primarily due to the downsizing of educational software development activities
as the Company reduced staff, significant reduction in educational software
marketing expenses, and other associated overhead costs. Another large reduction
was realized in facility lease expense after the Company moved to its current
location in July 1998. A significant increase in royalty expense was experienced
due to the agreement between the Company and TSRL to pay royalties on
GastroPlus(TM) sales; however, reductions outweighed increases in selling,
general and administrative expenses. For Words+, expenses decreased $235,000, or
13.3%, due to reductions in the employee field sales force and their payroll
related expenses, reducing trade shows and travel expenses, reducing marketing
cost by consolidating the management of two companies' marketing departments
into one person, and reducing advertising and newsletter printing costs. These
reductions outweighed increases in other expenses such as commissions to
independent sales representatives, utilities and royalties.

RESEARCH AND DEVELOPMENT
- ------------------------
         The Company incurred approximately $415,000 of research and development
costs for both companies during FY99. Of this amount, $196,000 was capitalized
and $219,000 was expensed. For FY98, the Company incurred approximately
$1,015,000 of research and development costs, of which approximately $625,000
was capitalized and approximately $390,000 was expensed. The 59.1% decrease in
research and development expenditure from FY98 to FY99 was due to the
significant reduction in educational simulation development, as well as a
reduction in Words+'s R&D expenses.

LOSS FROM OPERATIONS
- --------------------
         During FY99, the Company incurred a loss of approximately $709,000 as
compared to a loss of $2,184,000 for FY98. Management attributes the reduction
in net loss from operations to increased sales and decreased expenses, including
Selling, General and Administrative expenses.

INCOME FROM GRANT
- -----------------
         For FY99, the Company received the final $150,000 of a $300,000 Phase
II SBIR grant from the National Science Foundation to develop software to allow
physically-disabled students to perform simulated laboratory experiments on a
computer. For FY98, the Company received $150,000, the first two $75,000
semi-annual payments under this grant.


                                       15
<PAGE>


INTEREST INCOME
- ---------------
         Interest income for FY99 decreased to $5,000 from $58,000 in FY98. This
decrease is primarily due to the interest earned on investment activities in
commercial notes through a highly qualified financial institution being reduced
because portions of the Company's capital resources were used in the Company's
operations.

INTEREST EXPENSE
- ----------------
         Interest expense for FY99 increased to $21,000, or 31.3%, from $16,000
in FY98. This increase is primarily due to interest charges incurred for the
Company's revolving line of credit and interest on capitalized lease
obligations.

LOSS ON INVESTMENT IN HEALTHWEB, INC., AT EQUITY
- ------------------------------------------------
         Loss on investment for FY99 was reduced to $0 from the loss of $75,000
in FY98. During FY98, the Company incurred approximately $75,000 of expenses in
forming a joint venture called HealthWeb, Inc. to provide health information
through its Internet web site HealthData.com. The Company holds 4,500,000 (50%)
shares of the 9,000,000 shares issued in HealthWeb, Inc., which is a California
corporation. Because of limited resources, the Company discontinued its support
of HealthWeb, Inc. and currently HealthWeb, Inc. is in a state of non-operation.

INCOME TAXES
- ------------
         Income taxes were $1,600 for FY99 as well as FY98.

NET LOSS
- --------
         Net loss for FY99 decreased $1,492,000, or 72.1%, to a net loss of
$577,000, compared to the net loss of $2,069,000 for FY98. Management attributes
this decline primarily to the significant increases in sales, decreases in cost
of sales, decreases in selling, general and administrative expenses, and
decreases in research and development expenses compared to FY98.


FY98 COMPARED WITH FY97
================================================================================

NET SALES
- ---------
         Net sales for FY98 increased by $152,000 or 6.1%, to $2,645,000
compared to $2,493,000 for FY97. Management attributes the majority of this
increase primarily to two factors: (1) an approximately $40,000 increase in
educational software sales, and (2) a $98,000 increase in sales of Freedom 2000,
a communication system. Another $14,000 was comprised of an overall increase in
IST and Simplicity sales offset by a decrease in MultiVoice and MessageMate
sales.

COST OF SALES
- -------------
         Cost of sales for FY98 increased by $504,000 or 40.2% to $1,756,000
from $1,252,000 in FY97. As a percentage of sales, cost of sales was 66.4% for
the FY98, compared to 50.2% for the FY97, indicating a 16.2% increase.
Management attributes this increase in cost of sales primarily to the
amortization of capitalized educational software which increased by $452,000 or
1412.5% to $484,000 compared to $32,000 in FY97. The other 2.1% of this increase
was the result of an overall increase in production cost.

                                       16
<PAGE>

SELLING, GENERAL AND ADMINISTRATIVE EXPENSES
- --------------------------------------------
         Selling, general and administrative expenses for FY98 increased by
$406,000, or 17.8% to $2,683,000, compared to $2,277,000 for FY97. As a
percentage of net sales, selling, general and administrative expenses increased
by 10.1% to 101.4% in FY98 from 91.3% in FY97. Management attributes this
increase primarily to the expansion of sales force in Words+, including
salaries, equipment, travel expenses, and tradeshows. Other significant increase
in expenses are consultation fees, higher depreciation amounts, business
insurance and health insurance, wages and payroll taxes, moving expenses to the
new facility, ads and associated printing costs, public relation costs and
amortization costs on investments in commercial bonds.

RESEARCH AND DEVELOPMENT
- ------------------------
         The Company incurred approximately $1,015,000 of research and
development costs for FY98, of which approximately $625,000 was capitalized and
$390,000 was expensed. For FY97, the Company incurred approximately $765,000 of
research and development costs for FY97, of which approximately $632,000 was
capitalized and approximately $133,000 was expensed. The 32.7% increase in
research and development expenditure is due primarily to the unexpectedly long
development time for work associated with the conversion of educational software
to the C++ programming language necessary for compatibility on both Windows and
Macintosh computers.

INCOME FROM GRANT
- -----------------
         For FY98, the Company received $150,000, the first two $75,000
semi-annual payments of a $300,000 Phase II SBIR grant from the National Science
Foundation to develop software to allow physically-disabled students to perform
simulated laboratory experiments on a computer. For FY97, the Company received
the last one-third of a Phase I SBIR grant in the amount of $17,000.

INTEREST EXPENSE
- ----------------
         Interest expense for FY98 decreased $53,000, or 76.8% to $ 16,000. This
decrease is primarily due to the interest charges incurred for the Bridge Notes
and notes issued in August and September 1996 for which the Company does not
have such an obligation in this fiscal year.

FINANCING COSTS
- ---------------
         Financing costs for FY98 were $0 compared to $280,000 for FY97. The
$280,000 for FY97 was due to the issuance of 280,000 warrants in connection with
notes payable issued in December 1996 and January 1997. This financing cost was
being amortized over the term of the notes and the unamortized portion at the
time of the completion of the Company's initial public offering was charged to
earnings. The warrants entitled the holder to purchase one share of the
Company's Common Stock for $2.50 per share. The Company issued these warrants,
which had an exercise price that the Company estimated to be $1.00 less than the
fair value of the Company's Common Stock at the date of grant. Accordingly, the
Company recognized an additional financing cost of $280,000 in FY97.

LOSS ON INVESTMENT IN HEALTHWEB, INC., AT EQUITY
- ------------------------------------------------
         The Company incurred approximately $75,000 of expenses in forming a
joint venture called HealthWeb, Inc. to provide health information through its
Internet web site HealthData.com. The Company holds 4,500,000 (50%) shares of
the 9,000,000 shares issued in HealthWeb, Inc., which is a California
corporation. Because of limited resources, the Company discontinued its support
of HealthWeb, Inc. and currently HealthWeb, Inc. is in a state of nonoperation.

INCOME TAXES
- ------------
         Income taxes were $1,600 for FY98. For FY97 the Company recorded a tax
benefit of $39,000 because the Company received tax refund claims from
government agencies.

                                       17
<PAGE>

NET LOSS
- --------
         Net loss for FY98 increased $633,000, or 44.1%, to the net loss of
$2,069,000 compared to the net loss of $1,436,000 for FY97. Management
attributes this decline primarily to the non-cash write off of $350,000 for
capitalized educational software, the increase in selling, general and
administrative expenses for aggressive sales expansion and related costs, and
the loss incurred on the investment in HealthWeb, Inc.


SEASONALITY
================================================================================

         Sales of the Company's disability products exhibit relatively mild
seasonal fluctuations. The following table sets forth net sales information for
each of the Company's last 12 calendar quarters. This unaudited net sales
information has been prepared on the same basis as the annual information
presented elsewhere in this Form 10-KSB and, in the opinion of management,
reflects all adjustments (consisting of normal recurring entries) necessary for
a fair presentation of the information presented. Net sales for any quarter are
not necessarily indicative of sales for any future period.

<TABLE>
<CAPTION>

                                                                             Net Sales
                                                      ----------------------------------------------------------------
                                                       First         Second         Third         Fourth        Total
                                                      Quarter       Quarter        Quarter       Quarter
                                                      -------       -------        -------       -------       -------
                                                                               (in thousands)
<S>                                                     <C>           <C>            <C>            <C>         <C>
1999......................................              881           778            929            879         3,467
1998......................................              543           560            730            812         2,645
1997......................................              541           679            560            713         2,493
</TABLE>

         In general, management believes sales to schools are seasonal, with
greater sales to schools during the Company's third and fourth fiscal quarter
(March-May and June-August). There is not sufficient historical data at this
time to allow a detailed analysis of the seasonality of educational simulation
software. Sales of pharmaceutical simulations, which began in the first quarter
of FY99, are not expected to show significant seasonal behavior.


LIQUIDITY AND CAPITAL RESOURCES
================================================================================

         The Company's principal sources of capital have been cash flows from
its operations, a bank line of credit, a government grant, cash loans from the
officers on an as-needed basis, accruing and not paying full salaries to certain
executive officers and managers, and the remaining proceeds from the Company's
initial public offering.

         The Company has available a $100,000 revolving line of credit from a
bank. Interest is payable on a monthly basis at the bank's prime rate plus 3.0%.
The interest rate was 11.0% at August 31, 1999 and 11.50% at August 31, 1998. At
August 31, 1999, the outstanding balance under the revolving line of credit was
approximately $90,000, and at August 31, 1998, the outstanding balance under the
revolving line of credit was $97,000. The revolving line of credit is not
secured by any of the assets of the Company but is personally guaranteed by Mr.
Walter S. Woltosz, the Company's Chief Executive Officer, President and Chairman
of the Board of Directors.

                                       18
<PAGE>

         Beginning in August 1998, certain executive officers and managers
accepted reduced salaries on a temporary basis in order to protect the cash
assets of the Company. The unpaid portions of salaries are being accrued and
will be paid at such future time as management deems the Company's cash flow and
cash reserves are sufficient to make such payment without adverse effects to the
Company's financial position.

         In October 1997, the Company was awarded a follow-on $300,000 Phase II
SBIR grant from the National Science Foundation, the purpose of which was to
help fund the Company's development of educational simulation software for the
school and home study markets. The grant was paid in four equal payments of
$75,000 semi-annually and the Company received the final payment in June 1999.

         The Company believes that existing capital and anticipated funds from
operations, cost reductions from downsizing certain segments of operations, and
temporary salary reductions for senior management will be sufficient to meet its
anticipated cash needs for working capital and capital expenditures for at least
the next 13 months. Thereafter, if cash generated from operations is
insufficient to satisfy the Company's capital requirements, the Company may have
to sell additional equity or debt securities or obtain expanded credit
facilities. In the event such financing is needed in the future, there can be no
assurance that such financing will be available to the Company, or, if
available, that it will be in amounts and on terms acceptable to the Company. If
cash flows from operations are insufficient to continue operations at the
current level, and if no additional financing is obtained, then management will
restructure the Company in a way to preserve its pharmaceutical and disability
businesses while maintaining expenses within operating cash flows.

         In order to maintain quotation of its securities on the Nasdaq SmallCap
Market ("Nasdaq"), the Company has to maintain certain minimum financial
requirements. As of August 31, 1998 the Company ceased to meet one of the
requirements for continued listing, namely the Company's net tangible assets as
of August 31, 1998 were $1,284,000 which was below the $2,000,000 required by
the Nasdaq. Further, as of November 30, 1998 the market value of the Company's
public float was below the $4,000,000 required for continued Nasdaq listing. On
July 2, 1999, the Company was informed that its securities were being delisted
from the Nasdaq effective at the close of business on July 2, 1999 because the
Company did not meet the requirements for continued listing on Nasdaq.
Accordingly, trading in the shares of the Company's Common Stock is now
conducted on the Nasdaq's "Electronic Bulletin Board." Consequently, the
liquidity of the Company's securities may be impaired, not only in the number of
securities which can be bought and sold, but also through delays in the timing
of the transactions, reductions in security analysts' and the new media's
coverage of the Company, and lower prices for the Company's securities than
otherwise may be attained.

         As a result of the delisting, the Company's securities are subject to
Rule 15g-9 under the Securities Exchange Act of 1934, as amended (the "Exchange
Act"), which imposes additional sales practice requirements on broker-dealers
which sell such securities to persons other than established customers and
"accredited investors" (generally, individuals with net worths in excess of
$1,000,000 or annual incomes exceeding $200,000, or $300,000 together with their
spouses). For transactions covered by this rule, a broker-dealer must make a
special suitability determination for the purchaser and have received the
purchaser's written consent to the transaction prior to the sale. Consequently,
the rule may adversely affect the ability of broker-dealers to sell the
Company's securities acquired hereby in the secondary market.

                                       19
<PAGE>

         Securities and Exchange Commission ("Commission") regulations define a
"penny stock" to be any non- Nasdaq equity security that has a market price (as
therein defined) of less than $5.00 per share or with an exercise price of less
than $5.00 per share, subject to certain exceptions. For any transaction
involving a penny stock, unless exempt, the rules require delivery, prior to any
transaction in a penny stock, of a disclosure schedule prepared by the
Commission relating to the penny stock market. Disclosure is also required to be
made about commissions payable to both the broker-dealer and the registered
representative and current quotations for the securities. Finally, monthly
statements are required to be sent disclosing recent price information for the
penny stock held in the account and information on the limited market in penny
stocks.

         The foregoing required penny stock restrictions will not apply to the
Company's securities if such securities are listed on Nasdaq and have certain
price and volume information provided on a current and continuing basis or meet
certain minimum tangible assets or average revenue criteria. There can be no
assurance that the Company's securities will qualify for exemption from these
restrictions. In any event, even if the Company's securities were exempt from
such restrictions, it would remain subject to Section 15(b)(6) of the Exchange
Act, which gives the Commission the authority to prohibit any person that is
engaged in unlawful conduct while participating in a distribution of penny stock
from associating with a broker-dealer or participating in the distribution of a
penny stock, if the Commission finds that such a restriction would be in the
public interest. If the Company's securities were subject to the rules on penny
stocks, the market liquidity for the Company's securities would be severely
adversely affected.


YEAR 2000 COMPLIANCE
================================================================================

         The Company has completed a comprehensive review of its computer
systems to identify all software applications that could be affected by the
inability of many existing computer systems to process time-sensitive data
accurately beyond the year 1999 (referred to as the "Year 2000" issue). The
Company is also continuing to monitor its computer systems and the adequacy of
the processes and progress of third-party vendors of systems that may be
affected by the Year 2000 issue. The Company is dependent on third-party
computer systems and applications, particularly with respect to such critical
tasks as accounting, billing and buying, planning and paying for media, and it
also relies on its own computer systems. The Company completed its Year 2000
compliance program, however, the Company may experience cost overruns in the
future, which could have a material adverse effect on its business, results of
operations and financial condition. While management believes the Company's
procedures are designed to be successful, because of the complexity of the Year
2000 issue and the interdependence of organizations using computer systems, the
Company's efforts, or those of third parties with whom it interacts, may not be
satisfactorily completed in a timely fashion. If the Company fails to adequately
address the Year 2000 issue, then its business, results of operations and
financial condition could be materially adversely affected.

                          ITEM 7. FINANCIAL STATEMENTS

The response to this item is submitted as a separate section of this Form 10KSB
(see pages F-1 - F-20.)


    ITEM 8. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
                              FINANCIAL DISCLOSURE.

None.


                                       20
<PAGE>


PART III

           ITEM 9. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

         The information required by Item 9 is incorporated by reference from
the Company's definitive proxy statement (the "Proxy Statement") for its 2000
annual stockholders' meeting, which is hereby incorporated by reference.

                        ITEM 10. EXECUTIVE COMPENSATION

The information required by Item 10 is incorporated by reference from the
Company's Proxy Statement for its 2000 annual stockholders' meeting, which is
hereby incorporated by reference.

    ITEM 11. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The information required by Item 11 is incorporated by reference from
the Company's Proxy Statement for its 2000 annual stockholders' meeting, which
is hereby incorporated by reference.


            ITEM 12. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         The information required by Item 12 will be contained in the Proxy
Statement, which is incorporated by reference.


                   ITEM 13. EXHIBITS AND REPORTS ON FORM 8-K

(a)      The following exhibits are filed as part of this report as required by
         Item 601 of Regulation S-B:



                                       21
<PAGE>


EXHIBIT
NUMBER                     DESCRIPTION
- ------                     -----------

     3.1    Articles of Incorporation of the Registrant (1)
     3.2    Amended and Restated Bylaws of the Registrant (1)
     4.1    Articles of Incorporation of the Registrant (incorporated by
            reference to Exhibit 3.1 hereof) and Bylaws of the Registrant
            (incorporated by reference to Exhibit 3.2 hereof)
     4.2    Form of Common Stock Certificate (1)
     4.3    Share Exchange Agreement (1)
     10.1   Simulations Plus, Inc. 1996 Stock Option Plan (the "Option Plan")
            and terms of agreements relating thereto (1)+
     10.2   Subscription Agreement with Patricia Ann O'Neil (1)
     10.3   Security Agreement with Patricia Ann O'Neil (1)
     10.4   Promissory Note made by the Registrant in favor of Patricia Ann
            O'Neil (1)
     10.5   Warrants to purchase 150,000 shares of Common Stock of the
            Registrant issued to Patricia Ann O'Neil (1)
     10.6   First Amendment to Agreement with Patricia Ann O'Neil (1)
     10.7   Subscription Agreement with Fernando Zamudio (1)
     10.8   Security Agreement with Fernando Zamudio (1)
     10.9   Promissory Note made by the Registrant in favor of Fernando Zamudio
            (1)
     10.10  Warrant to purchase 100,000 shares of Common Stock of the Registrant
            issued to Fernando Zamudio (1)
     10.11  Employment Agreement by and between the Registrant and Walter S.
            Woltosz (1) +
     10.12  Performance Warrant Agreement by and between the Registrant and
            Walter S. Woltosz + Virginia E. Woltosz (2) +
     10.13  Software Acquisition Agreement by and Between the Registrant and
            Michael B. Bolger (1)
     10.14  Sublease Agreement dated May 7, 1993 by and between the Registrant
            and Westholme Partners (along with Consent to Sublease and master
            lease agreement) (1)
     10.15  Lease Agreements dated August 22, 1996 by and between Words+, Inc.
            and Abbey-Sierra LLC (1)
     10.16  Form of 10% Amended and Restated Promissory Note issued in
            connection with the Registrant's Private Placement (2)
     10.17  Form of Subscription Agreement relative to the Registrant's Private
            Placement (1)
     10.18  Form of Lock-Up Agreement with Bridge Lenders (2)
     10.19  Form of Indemnification Agreement (1)
     10.20  Form of Lock-Up Agreement with the Woltosz' (2)
     10.21  Letter of Intent by and between the Registrant and Therapeutic
            Systems Research Laboratories (1)
     10.22  Form of Representative's Warrant to be issued by the Registrant in
            favor of the Representative (2)
     10.23  Form of Warrant issued to Bridge Lenders (2)
     10.24  License Agreement by and between the Registrant and Therapeutic
            Systems Research Laboratories (3)
     10.25  Grant Award Letter from National Science Foundation (4)
     10.26  Distribution Agreement with Teijin Systems Technology LTD. (4)
     10.27  Lease Agreements by and between Simulations Plus, Inc. and Martin
            Properties, Inc. (4)
     10.28  Software OEM Agreement for Assistive Market Developer by and between
            Words+, Inc. and Digital Equipment Corporation. (4)
     10.29  Purchase Agreement by and between Words+, Inc. and Epson America,
            Inc. (4)
     10.30  License Agreement with Absorption Systems, LP. (5)
     10.31  Service contract with The Kriegsman Group. (5)
     10.32  Letter of Engagement with Banchik & Associates. (5)
     10.33  Letter of Intent for Cooperative Alliance with Absorption Systems,
            LP. (5)
     27.1   Financial Data Schedule (5)

                                       22
<PAGE>

     (1)    Incorporated by reference to the Company's Registration Statement on
            Form SB-2 (Registration No. 333-6680) filed on March 25, 1997 (the
            "Registration Statement").

     (2)    Incorporated by reference to Pre-Effective Amendment No. 1 to the
            Registration Statement filed on May 27, 1997.

     (3)    Incorporated by reference to the Company's Form 10-KSB for the
            fiscal year ended August 31, 1997.

     (4)    Incorporated by reference to the Company's Form 10-KSB for the
            fiscal year ended August 31, 1998.

     (5)    Filed herewith.

     +      Management Contract or Compensatory Plan.


(b)      Reports on Form 8-K

         None.



                                       23
<PAGE>


         SIGNATURES

         Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized, in the City of
Palmdale, State of California, On December 14, 1999.

                                           SIMULATIONS PLUS, INC.


                                           By /s/ Momoko A. Beran
                                             -------------------------------
                                              Momoko A. Beran
                                              CHIEF FINANCIAL OFFICER


         Pursuant to the requirements of the Securities Exchange Act of 1934,
this report has been signed below by the following persons on behalf of
Registrant and in the capacities indicated on December 14, 1999.


       SIGNATURE                                  TITLE


/s/ Walter S. Woltosz
- ----------------------------              Chairman of the Board of Directors
    Walter S. Woltosz                     and Chief Executive Officer


/s/ Virginia E. Woltosz
- ----------------------------              Vice President, Secretary and
    Virginia Woltosz                      Director of the Company and Words+


/s/ Dr. David Z. D'Argenio
- ----------------------------
    Dr. David Z. D'Argenio                Director and Consultant to the Company



- ----------------------------
    Dr. Richard Weiss                     Director


/s/ Momoko A. Beran
- ----------------------------
    Momoko A. Beran                       Chief Financial Officer of the Company


                                       24


<PAGE>

                             SIMULATIONS PLUS, INC.
                                 AND SUBSIDIARY
                        CONSOLIDATED FINANCIAL STATEMENTS
                               FOR THE YEARS ENDED
                            AUGUST 31, 1999 AND 1998


















<PAGE>


                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                                        CONTENTS
                                                                 AUGUST 31, 1999
================================================================================


                                                                            Page

REPORT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS                           1

FINANCIAL STATEMENTS

     Consolidated Balance Sheet                                              2

     Consolidated Statements of Operations                                   3

     Consolidated Statements of Shareholders' Equity                         4

     Consolidated Statements of Cash Flows                                 5 - 6

     Notes to Consolidated Financial Statements                           7 - 20



<PAGE>



               REPORT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS



To the Board of Directors and Shareholders of
Simulations Plus, Inc.


We have audited the accompanying consolidated balance sheet of Simulations Plus,
Inc. (a California corporation) and subsidiary as of August 31, 1999, and the
related consolidated statements of operations, shareholders' equity, and cash
flows for each of the two years in the period ended August 31, 1999. These
financial statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audits.

We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in
all material respects, the consolidated financial position of Simulations Plus,
Inc. and subsidiary as of August 31, 1999, and the consolidated results of their
operations and their consolidated cash flows for each of the two years in the
period ended August 31, 1999 in conformity with generally accepted accounting
principles.


/s/ SINGER LEWAK GREENBAUM & GOLDSTEIN LLP

SINGER LEWAK GREENBAUM & GOLDSTEIN LLP

Los Angeles, California
October 29, 1999

                                      F-1
<PAGE>
<TABLE>

                                                                               SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                                                          CONSOLIDATED BALANCE SHEET
                                                                                                     AUGUST 31, 1999
====================================================================================================================

<CAPTION>
<S>                                                                                                <C>
                                              ASSETS
CURRENT ASSETS
     Cash and cash equivalents                                                                     $         52,323
     Accounts receivable, net of allowance for doubtful
         accounts of $17,830                                                                                570,346
     Inventory                                                                                              193,174
                                                                                                   -----------------

              Total current assets                                                                          815,843

CAPITALIZED COMPUTER SOFTWARE DEVELOPMENT COSTS, net
     of accumulated amortization of $1,154,424                                                              595,990
FURNITURE AND EQUIPMENT, net                                                                                149,420
OTHER ASSETS                                                                                                 50,001
                                                                                                   -----------------

                  TOTAL ASSETS                                                                     $      1,611,254
                                                                                                   =================

                                LIABILITIES AND SHAREHOLDERS' EQUITY
CURRENT LIABILITIES
     Line of credit                                                                                $         89,828
     Accounts payable                                                                                       244,047
     Accrued payroll and other expenses                                                                     430,038
     Accrued warranty and service costs                                                                      70,761
     Current portion of capitalized lease obligations                                                        31,982
                                                                                                   -----------------

         Total current liabilities                                                                          866,656

CAPITALIZED LEASE OBLIGATIONS, net of current portion                                                         3,940
                                                                                                   -----------------

              Total liabilities                                                                             870,596
                                                                                                   -----------------

COMMITMENTS AND CONTINGENCIES

SHAREHOLDERS' EQUITY
     Preferred stock, $0.001 par value
         10,000,000 shares authorized
         no shares issued and outstanding                                                                         -
     Common stock, $0.001 par value
         20,000,000 shares authorized
         3,383,531 shares issued and outstanding                                                              3,384
     Additional paid-in capital                                                                           4,629,268
     Accumulated deficit                                                                                 (3,891,994)
                                                                                                   -----------------

              Total shareholders' equity                                                                    740,658
                                                                                                   -----------------

                  TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY                                       $      1,611,254
                                                                                                   =================

                    The accompanying notes are an integral part of these financial statements.

</TABLE>
                                                          F-2

<PAGE>
<TABLE>


                                                                               SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                                               CONSOLIDATED STATEMENTS OF OPERATIONS
                                                                                      FOR THE YEARS ENDED AUGUST 31,
====================================================================================================================
<CAPTION>


                                                                                      1999               1998
                                                                                ----------------    ----------------
<S>                                                                             <C>                 <C>
NET SALES                                                                       $     3,466,805     $     2,645,159

COST OF SALES                                                                         1,648,510           1,755,905
                                                                                ----------------    ----------------

GROSS PROFIT                                                                          1,818,295             889,254
                                                                                ----------------    ----------------

OPERATING EXPENSES
     Selling, general, and administrative                                             2,308,828           2,683,282
     Research and development                                                           218,514             390,446
                                                                                ----------------    ----------------

         Total operating expenses                                                     2,527,342           3,073,728
                                                                                ----------------    ----------------

LOSS FROM OPERATIONS                                                                   (709,047)         (2,184,474)
                                                                                ----------------    ----------------

OTHER INCOME (EXPENSE)
     Interest income                                                                      5,388              58,215
     Income from grant                                                                  150,000             150,000
     Interest expense                                                                   (21,406)            (16,447)
     Loss in investment of Healthweb, Inc., at equity                                         -             (74,933)
                                                                                ----------------    ----------------

         Total other income (expense)                                                   133,982             116,835
                                                                                ----------------    ----------------

LOSS BEFORE PROVISION FOR INCOME TAXES                                                 (575,065)         (2,067,639)

PROVISION FOR INCOME TAXES                                                                1,600               1,600
                                                                                ----------------    ----------------

NET LOSS                                                                        $      (576,665)    $    (2,069,239)
                                                                                ================    ================

BASIC LOSS PER SHARE                                                            $         (0.17)    $         (0.62)
                                                                                ================    ================

DILUTED LOSS PER SHARE                                                          $         (0.17)    $         (0.62)
                                                                                ================    ================

WEIGHTED-AVERAGE COMMON SHARES OUTSTANDING                                            3,377,543           3,350,000
                                                                                ================    ================



                    The accompanying notes are an integral part of these financial statements.
</TABLE>

                                                           F-3
<PAGE>
<TABLE>

                                                                        SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                              CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY
                                                                               FOR THE YEARS ENDED AUGUST 31,
=============================================================================================================
<CAPTION>

                                                              Additional
                                   Common Stock                Paid-in          Accumulated
                               Shares        Amount            Capital            Deficit           Total
                             ---------     ---------         ------------      --------------   -------------
<S>                          <C>           <C>               <C>               <C>              <C>
BALANCE, AUGUST 31,
   1997                      3,350,000     $   3,350         $  4,595,771      $  (1,246,090)   $  3,353,031

NET LOSS                                                                          (2,069,239)      (2,069,239)
                             ---------     ---------         ------------      --------------   -------------

BALANCE, AUGUST 31,
   1998                      3,350,000         3,350            4,595,771         (3,315,329)      1,283,792

ISSUANCE OF COMMON
   STOCK FOR LEASEHOLD
   IMPROVEMENTS                 33,531            34               33,497                             33,531

NET LOSS                                                                            (576,665)       (576,665)
                             ---------     ---------         ------------      --------------   -------------

BALANCE, AUGUST 31,
   1999                      3,383,531     $   3,384         $  4,629,268      $  (3,891,994)   $    740,658
                             =========     =========         ============      ==============   =============

                    The accompanying notes are an integral part of these financial statements.


                                                           F-4
</TABLE>

<PAGE>
<TABLE>

                                                                               SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                                               CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                                                      FOR THE YEARS ENDED AUGUST 31,
====================================================================================================================
<CAPTION>

                                                                                      1999               1998
                                                                                ----------------    ----------------
<S>                                                                             <C>                 <C>
CASH FLOWS FROM OPERATING ACTIVITIES
   Net loss                                                                     $      (576,665)    $    (2,069,239)
   Adjustments to reconcile net loss to net cash
     provided by (used in) operating activities
       Depreciation and amortization of furniture and equipment                          80,497              67,794
       Amortization of capitalized software development costs                           423,267             564,299
       Loss in investment of Healthweb, Inc., at equity                                       -              74,933
   (Increase) decrease in
     Accounts receivable                                                               (194,576)               (719)
     Income tax receivable                                                               28,941              28,485
     Inventory                                                                          155,501            (172,570)
     Other assets                                                                        (4,013)            (10,992)
   Increase (decrease) in
     Accounts payable                                                                   (90,712)            194,217
     Accrued payroll and other expenses                                                 244,655              34,674
     Accrued warranty and service costs                                                  22,265              (3,363)
                                                                                ----------------    ----------------

         Net cash provided by (used in) operating activities                             89,160          (1,292,481)
                                                                                ----------------    ----------------

CASH FLOWS FROM INVESTING ACTIVITIES
   Purchases of furniture and equipment                                                       -             (20,858)
   Capitalized computer software development cost                                      (196,130)           (640,706)
   Advances to Healthweb, Inc., at equity                                                     -             (74,933)
                                                                                ----------------    ----------------

         Net cash used in investing activities                                         (196,130)           (736,497)
                                                                                ----------------    ----------------

CASH FLOWS FROM FINANCING ACTIVITIES
   Payments on line of credit                                                            (7,300)             97,128
   Payments on capitalized lease obligations                                            (31,561)            (26,757)
                                                                                ----------------    ----------------

         Net cash provided by (used in) financing activities                            (38,861)             70,371
                                                                                ----------------    ----------------

           Net decrease in cash and cash equivalents                                   (145,831)         (1,958,607)

CASH AND CASH EQUIVALENTS, BEGINNING OF YEAR                                            198,154           2,156,761
                                                                                ----------------    ----------------

CASH AND CASH EQUIVALENTS, END OF YEAR                                          $        52,323     $       198,154
                                                                                ================    ================


SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION
During the years ended August 31, 1999 and 1998, the Company paid $1,600 and
$1,600, respectively, in income taxes and $21,406 and $16,447, respectively, in
interest.

                    The accompanying notes are an integral part of these financial statements.
</TABLE>

                                                      F-5
<PAGE>


                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                               CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED)
                                                  FOR THE YEARS ENDED AUGUST 31,
================================================================================

SUPPLEMENTAL SCHEDULE OF NON-CASH INVESTING AND FINANCING ACTIVITIES
The Company entered into capital lease obligations of $6,183 and $6,473 during
the years ended August 31, 1999 and 1998, respectively, and transferred $46,693
of computer hardware from inventory to furniture and equipment during the year
ended August 31, 1998.

During the year ended August 31, 1999, the Company issued 33,531 shares of
common stock in exchange for $33,531 of leasehold improvements.


The accompanying notes are an integral part of these financial statements.


                                       F-6
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================

NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES

         Organization
         ------------
         Simulations Plus, Inc. was incorporated on July 17, 1996. On August 29,
         1996, the shareholders of Words+, Inc. exchanged their 2,000 shares of
         Words+, Inc. common stock for 2,200,000 shares of Simulations Plus,
         Inc. common stock, and Words+, Inc. became a wholly-owned subsidiary of
         Simulations Plus, Inc. (collectively, the "Company"). The effect of the
         stock-for-stock exchange is presented retroactively in the accompanying
         consolidated financial statements. All intercompany accounts and
         transactions have been eliminated.

         Lines of Business
         -----------------
         The Company designs and develops computer software and manufactures
         augmentative communication devices and computer access products that
         provide a voice for those who cannot speak and allow
         physically-disabled persons to operate a standard computer. In
         addition, the Company designs and develops pharmaceutical simulation
         software to promote cost-effective solutions to a number of problems in
         pharmaceutical research and in the education of pharmacy and medical
         students. The Company also developed and sells interactive, educational
         software programs that simulate science experiments conducted in high
         school science classes.

         Basis of Presentation
         ---------------------
         The accompanying financial statements have been prepared in accordance
         with generally accepted accounting principles which contemplate
         continuation of the Company as a going concern. However, the Company
         has sustained substantial losses from operations in recent years.

         The Company believes that existing capital and anticipated funds from
         operations, cost reductions from downsizing certain segments of
         operations, and temporary salary reductions for senior management will
         be sufficient to meet its anticipated cash needs for working capital
         and capital expenditures for at least the next 13 months. Thereafter,
         if cash generated from operations is insufficient to satisfy the
         Company's capital requirements, the Company may have to sell additional
         equity or debt securities or obtain expanded credit facilities. In the
         event such financing is needed in the future, there can be no assurance
         that such financing will be available to the Company, or, if available,
         that it will be in amounts and on terms acceptable to the Company. If
         cash flows from operations are insufficient to continue operations at
         the current level, and if no additional financing is obtained, then
         management will restructure the Company in a way to preserve its
         pharmaceutical and disability businesses while maintaining expenses
         within operating cash flows.

                                       F-7
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

         Estimates
         ---------
         The preparation of financial statements in conformity with generally
         accepted accounting principles requires management to make estimates
         and assumptions that affect the reported amounts of assets and
         liabilities and the disclosures of contingent assets and liabilities at
         the date of the financial statements, as well as the reported amounts
         of revenues and expenses during the reporting period. Actual results
         could differ from those estimates.

         Cash and Cash Equivalents
         -------------------------
         For purposes of the statements of cash flows, the Company considers all
         highly-liquid investments purchased with original maturities of three
         months or less to be cash equivalents.

         Inventory
         ---------
         Inventory is stated at the lower of cost (first-in, first-out basis) or
         market and consists primarily of computers and peripheral computer
         equipment.

         Furniture and Equipment
         -----------------------
         Furniture and equipment, including equipment under capital leases, are
         recorded at cost, less accumulated depreciation and amortization.
         Depreciation and amortization are provided using the straight-line
         method over the estimated useful lives as follows:

                  Equipment                                            5 years
                  Computer equipment                              3 to 7 years
                  Furniture and fixtures                          5 to 7 years
                  Leasehold improvements                               5 years

         Maintenance and minor replacements are charged to expense as incurred.
         Gains and losses on disposals are included in the results of
         operations.

         Advertising
         -----------
         The Company expenses advertising costs as incurred. Advertising costs
         for the years ended August 31, 1999 and 1998 were $3,656 and $66,537,
         respectively.

         Research and Development Costs
         ------------------------------
         Research and development costs are charged to expense as incurred until
         technological feasibility has been established. These costs consist
         primarily of salaries and direct payroll related costs.

                                       F-8
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

         Software Development Costs
         --------------------------
         Software development costs are capitalized in accordance with Statement
         of Financial Accounting Standards ("SFAS") No. 86, "Accounting for the
         Cost of Computer Software to be Sold, Leased, or Otherwise Marketed."
         Capitalization of software development costs begins upon the
         establishment of technological feasibility and is discontinued when the
         product is available for sale. The establishment of technological
         feasibility and the ongoing assessment for recoverability of
         capitalized software development costs require considerable judgment by
         management with respect to certain external factors including, but not
         limited to, technological feasibility, anticipated future gross
         revenues, estimated economic life, and changes in software and hardware
         technologies. Capitalized software development costs are comprised
         primarily of salaries and direct payroll related costs and the purchase
         of existing software to be used in the Company's software products.

         Amortization of capitalized software development costs is provided on a
         product-by-product basis on the straight-line method over the estimated
         economic life of the products (not to exceed three years). Management
         periodically compares estimated net realizable value by product with
         the amount of software development costs capitalized for that product
         to ensure the amount capitalized is not in excess of the amount to be
         recovered through revenues. Any such excess of capitalized software
         development costs to expected net realizable value is expensed at that
         time. As of August 31, 1999 and 1998, the Company expensed $182,925 and
         $350,000, respectively, of capitalized software development costs
         relating to educational software.

         Revenue Recognition
         -------------------
         The Company recognizes revenues related to software licenses and
         software maintenance in accordance with the American Institute of
         Certified Public Accountants ("AICPA") Statements of Position No. 97-2,
         "Software Revenue Recognition." Product revenue is recorded at the time
         of shipment, net of estimated allowances and returns. Post-contract
         customer support ("PCS") obligations are insignificant; therefore,
         revenue for PCS is recognized at the time of shipment, and the costs of
         providing such support services are accrued and amortized over the
         obligation period. The Company provides, for a fee, additional training
         and service calls to its customers and recognizes revenue at the time
         the training or service call is provided.

                                       F-9
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

         Income Taxes
         ------------
         The Company utilizes SFAS No. 109, "Accounting for Income Taxes," which
         requires the recognition of deferred tax assets and liabilities for the
         expected future tax consequences of events that have been included in
         the financial statements or tax returns. Under this method, deferred
         income taxes are recognized for the tax consequences in future years of
         differences between the tax bases of assets and liabilities and their
         financial reporting amounts at each year-end based on enacted tax laws
         and statutory tax rates applicable to the periods in which the
         differences are expected to affect taxable income. Valuation allowances
         are established, when necessary, to reduce deferred tax assets to the
         amount expected to be realized. The provision for income taxes
         represents the tax payable for the period and the change during the
         period in deferred tax assets and liabilities.

         Fair Value of Financial Instruments
         -----------------------------------
         The Company measures its financial assets and liabilities in accordance
         with generally accepted accounting principles. For certain of the
         Company's financial instruments, including cash and cash equivalents,
         accounts receivable, accounts payable, accrued payroll and other
         expenses, and accrued warranty and service costs, the carrying amounts
         approximate fair value due to their short maturities. The amounts shown
         for capitalized lease obligations also approximate fair value because
         current interest rates offered to the Company for leases of similar
         maturities are substantially the same.

         Stock Options and Warrants
         --------------------------
         During 1995, the Financial Accounting Standards Board ("FASB") issued
         SFAS No. 123, "Accounting for Stock-Based Compensation," which defines
         a fair value based method of accounting for stock-based compensation.
         However, SFAS No. 123 allows an entity to continue to measure
         compensation cost related to stock and stock options issued to
         employees using the intrinsic method of accounting prescribed by
         Accounting Principles Board Opinion No. 25 ("APB 25"), "Accounting for
         Stock Issued to Employees." Entities electing to remain with the
         accounting method of APB 25 must make pro forma disclosures of net
         income and earnings per share, as if the fair value method of
         accounting defined in SFAS No. 123 had been applied. The Company has
         elected to account for its stock-based compensation to employees under
         APB 25.


                                       F-10
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

         Net Loss per Share
         ------------------
         The Company reports earnings per share in accordance with SFAS No. 128,
         "Earnings per Share." Basic earnings per share is computed by dividing
         income available to common shareholders by the weighted-average number
         of common shares available. Diluted earnings per share is computed
         similar to basic earnings per share except that the denominator is
         increased to include the number of additional common shares that would
         have been outstanding if the potential common shares had been issued
         and if the additional common shares were dilutive. Because the Company
         has incurred net losses, basic and diluted loss per share are the same.

         Concentrations and Uncertainties
         --------------------------------
         International sales accounted for 19% and 12% of net sales for the
         years ended August 31, 1999 and 1998, respectively. Amounts due from
         Medicaid represented 24% of the net accounts receivable balance at
         August 31, 1999.

         The Company operates in the computer software industry which is highly
         competitive and changes rapidly. The Company's operating results could
         be significantly affected by its ability to develop new products and
         find new distribution channels for new and existing products.

         The Company does not manufacture certain of its components including
         the computer that is used in one of the Company's products. Such
         computer is sourced by the Company from a single vendor. The Company
         also uses a number of pictographic symbols that are used in its
         software products which are licensed from a third party. The inability
         of the Company to obtain computers used in its products or to renew its
         licensing agreement to use pictographic symbols could negatively impact
         the Company's financial position, results of operations, and cash
         flows.

         Comprehensive Income
         --------------------
         For the year ended August 31, 1999, the Company adopted SFAS No. 130,
         "Reporting Comprehensive Income." This statement establishes standards
         for reporting comprehensive income and its components in a financial
         statement. Comprehensive income as defined includes all changes in
         equity (net assets) during a period from non-owner sources. Examples of
         items to be included in comprehensive income, which are excluded from
         net income, include foreign currency translation adjustments and
         unrealized gains and losses on available-for-sale securities.
         Comprehensive income is not presented in the Company's financials
         statements since the Company did not have any of the items of
         comprehensive income in any period presented.

                                      F-11
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 1 - SUMMARY OF BUSINESS AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

         Recently Issued Accounting Pronouncements
         -----------------------------------------
         SFAS No. 133, "Accounting for Derivative Instruments and Hedging
         Activities," is effective for financial statements with fiscal years
         beginning after June 15, 1999. SFAS No. 133 establishes accounting and
         reporting standards for derivative instruments, including certain
         derivative instruments embedded in other contracts, and for hedging
         activities. This statement is not applicable to the Company.

         SFAS No. 134, "Accounting for Mortgage-Backed Securities Retained after
         the Securitization of Mortgage Loans Held for Sale by a Mortgage
         Banking Enterprise," is effective for financial statements with the
         first fiscal quarter beginning after December 15, 1998. This statement
         is not applicable to the Company.

         SFAS No. 135, "Rescission of FASB Statement No. 75 and Technical
         Corrections," is effective for financial statements with fiscal years
         beginning February 1999. This statement is not applicable to the
         Company.

         In June 1999, the FASB issued SFAS No. 136, "Transfer of Assets to a
         Not-for-Profit Organization or Charitable Trust that Raises or Holds
         Contributions for Others." This statement is not applicable to the
         Company.

         In June 1999, the FASB issued SFAS No. 137, "Accounting for Derivative
         Instruments and Hedging Activities." The Company does not expect
         adoption of SFAS No. 137 to have a material impact, if any, on its
         financial position or results of operations.


NOTE 2 - CASH AND CASH EQUIVALENTS

         The Company maintains cash deposits at banks located in California.
         Deposits at each bank are insured by the Federal Deposit Insurance
         Corporation up to $100,000. The Company has not experienced any losses
         in such accounts and believes it is not exposed to any significant
         credit risk on cash and cash equivalents.




                                      F-12
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 3 - FURNITURE AND EQUIPMENT

         Furniture and equipment at August 31, 1999 consisted of the following:

            Equipment                                               $    50,185
            Computer equipment                                          338,308
            Furniture and fixtures                                       45,036
            Leasehold improvements                                       39,434
                                                                    ------------

                                                                        472,963
            Less accumulated depreciation and amortization              323,543
                                                                    ------------
                TOTAL                                               $   149,420
                                                                    ============

         Depreciation and amortization expense was $80,497 and $67,794 for the
         years ended August 31, 1999 and 1998, respectively.


NOTE 4 - COMMITMENTS AND CONTINGENCIES

         Leases
         ------
         The Company leases certain facilities for its corporate and operations
         offices under a non-cancelable operating lease agreement that expires
         in 2001. The Company also leases certain office and computer equipment
         under non-cancelable capital lease arrangements.

         Future minimum lease payments under non-cancelable capital and
         operating leases with initial or remaining terms of one year or more
         are as follows:

              Year Ending                             Operating        Capital
               August 31,                              Leases           Leases
                                                    ------------    ------------
                 2000                               $   131,040     $    35,526
                 2001                                   140,400           5,583
                                                    ------------    ------------

                                                    $   271,440          41,109
                                                    ============
              Less amount representing interest                           5,187
                                                                    ------------
                                                                         35,922
              Less current portion                                       31,982
                                                                    ------------
                  LONG-TERM PORTION                                 $     3,940
                                                                    ============

         Included in furniture and equipment is capitalized leased equipment of
         $126,421 with accumulated depreciation of $102,290 at August 31, 1999.

                                      F-13
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 4 - COMMITMENTS AND CONTINGENCIES (CONTINUED)

         Leases (Continued)
         ------
         Rent expense was $157,257 and $173,209 for the years ended August 31,
         1999 and 1998, respectively.

         Employee Agreement
         ------------------
         The Company entered into an employment agreement with its President
         that expired August 31, 1999. In November 1999, the Board of Directors
         approved an extension until August 31, 2002 with the same terms. The
         employment agreement provides for an annual salary of $150,000 and an
         annual bonus based on the Company's performance not to exceed $150,000.
         The agreement also provides that the Company may terminate the
         agreement upon 30 days written notice if termination is without cause.
         The Company's only obligation would be to pay its President the greater
         of a) 12 months salary or b) the remainder of the term of the
         employment agreement from the date of notice of termination.

         License Agreement
         -----------------
         The Company entered into an agreement with Therapeutic Systems Research
         Laboratory ("TSRL") to jointly develop a computer simulation of the
         absorption of drug compounds in the gastrointestinal tract. Upon
         execution of a definitive License Agreement, TSRL received a one-time
         payment of $75,000, plus a royalty of 20% of net sales of the
         absorption simulation. For the year ended August 31, 1999, the Company
         paid royalties of $46,511.

         Listing on Stock Exchange
         -------------------------

         In order to maintain quotation of its securities on the NASDAQ
         SmallCap Market ("NASDAQ"), the Company has to maintain certain
         minimum financial requirements. As of August 31, 1999 and 1998, the
         Company has ceased to meet one of the requirements for continued
         listing, namely the Company's net tangible assets as of August 31,
         1999 and 1998 were $754,000 and $1,284,000, respectively, which is
         below the $2,000,000 required by the NASDAQ. Further, as of November
         16, 1999, the market value of the Company's public float was below the
         $4,000,000 required for continued NASDAQ listing. The Company was
         unable to increase its net tangible assets and the market value of its
         public float to meet the NASDAQ's requirements for continued listing.
         The Company's securities were delisted from NASDAQ effective at the
         closing of July 2, 1999. Trading, if any, of the shares of common
         stock now need to be conducted in the over-the-counter markets in the
         so-called "pink sheets" or on the NASDAQ's "Electronic Bulletin
         Board." Consequently, the liquidity of the Company's securities could
         be impaired, not only in the number of securities which could be
         bought and sold, but also through delays in the timing of the
         transactions, reductions in security analysts' and the news media's
         coverage of the Company, and lower prices for the Company's securities
         than otherwise might be attained.



                                      F-14
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 5 - INCOME TAXES

         A reconciliation of the expected income tax (benefit) computed using
         the federal statutory income tax rate to the Company's effective income
         tax rate is as follows:
<TABLE>
<CAPTION>

                                                                                1999             1998
                                                                            ------------    -------------
             <S>                                                                 <C>              <C>
             Income tax computed at federal statutory tax rate                   (34.0)%          (34.0)%
             State taxes, net of federal benefit                                   0.1              0.1
             Change in valuation allowance                                        34.0             34.0
                                                                            ------------    -------------

                 TOTAL                                                             0.1%             0.1%
                                                                            ============    =============
</TABLE>

         Significant components of the Company's deferred tax assets and
         liabilities for income taxes at August 31 consisted of the following:
<TABLE>
<CAPTION>

                                                                                   1999               1998
                                                                              -------------       -------------
             <S>                                                              <C>                 <C>
             Deferred tax assets
                 Accrued payroll and other expenses                           $    159,959        $     40,989
                 Accrued warranty and service costs                                 28,304              19,318
                 Net operating loss carryforward                                 1,527,770           1,456,886
                 Other                                                                   -              22,667
                                                                              -------------       -------------

                                                                                 1,716,033           1,539,860
             Valuation allowance                                                 1,474,384           1,202,018
                                                                              -------------       -------------

                                                                                   241,649             337,842
                                                                              -------------       -------------
             Deferred tax liabilities
                 Fixed assets                                                       (3,253)             (9,958)
                 Capitalized computer software development
                      costs                                                       (238,396)           (327,884)
                                                                              -------------       -------------

                                                                                  (241,649)           (337,842)
                                                                              -------------       -------------

                          NET DEFERRED TAX ASSET                              $          -        $          -
                                                                              =============       ==============
</TABLE>

         The Company's valuation allowance increased by $272,366 during the year
         ended August 31, 1999. At August 31, 1999, the Company had federal and
         state net operating loss carryforwards of approximately $3,900,000 and
         $2,000,000, respectively, that expire throughout the year 2019.

                                      F-15
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 5 - INCOME TAXES (CONTINUED)

         The components of the income tax provision for the years ended August
         31 were as follows:

                                                    1999                1998
                                                 -----------         -----------
             Current
                 Federal                         $        -          $        -
                 State                                1,600               1,600
                                                 -----------         -----------

                                                      1,600               1,600
                                                 -----------         -----------
             Deferred
                 Federal                                  -                   -
                 State                                    -                   -
                                                 -----------         -----------

                                                          -                   -
                                                 -----------         -----------

                      TOTAL                      $    1,600          $    1,600
                                                 ===========         ===========


NOTE 6 - SHAREHOLDERS' EQUITY

         Warrants
         --------
         In August and September 1996, the Company entered into two Subscription
         Agreements whereby the Company issued 100,000 and 150,000 warrants,
         respectively, to purchase shares of common stock. The warrants are
         exercisable at $4.00 per share and expire five years from the date of
         grant.

         In January 1997, the Company entered into Subscription Agreements
         whereby the Company issued notes in the amount of $1,100,000 and issued
         280,000 warrants to purchase common stock. The warrants are exercisable
         at $2.50 per share, are subject to a 12-month-lock-up period, and
         expire five years from the grant date. The notes were repaid upon the
         completion of the Company's stock offering.

         Stock Option Plan
         -----------------
         In September 1996, the Board of Directors adopted and the shareholders
         approved the 1996 Stock Option Plan (the "Option Plan") under which a
         total of 250,000 shares of common stock has been reserved for issuance.
         In March 1999, the shareholders approved an increase in the number of
         shares that may be granted under the Option Plan to 500,000. The Option
         Plan terminates in 2006, subject to earlier termination by the Board of
         Directors.


                                      F-16
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 6 - SHAREHOLDERS' EQUITY (CONTINUED)

         Stock Option Plan (Continued)
         -----------------
         The following summarizes the stock option transactions:
<TABLE>
<CAPTION>

                                                                                                     Weighted-
                                                                                                      Average
                                                                                                     Exercise
                                                                                  Number              Price
                                                                                 of Shares           Per Share
                                                                                -----------         -----------
                 <S>                                                               <C>              <C>

                 Outstanding, August 31, 1997                                            -          $        -
                      Granted                                                       50,000          $     4.25
                      Expired/canceled                                              (6,260)         $     4.25
                                                                                -----------

                 Outstanding, August 31, 1998                                       43,740          $     4.25
                      Granted                                                      263,990          $     1.35
                      Expired/canceled                                             (13,410)         $     2.04
                                                                                -----------

                          OUTSTANDING, AUGUST 31, 1999                             294,320          $      1.74
                                                                                ===========

                          EXERCISABLE, AUGUST 31, 1999                               7,722          $      4.25
                                                                                ===========
</TABLE>

         The weighted-average remaining contractual life of options outstanding
         issued under the Plan is 9.11 years at August 31, 1999. The exercise
         prices for the options outstanding at August 31, 1999 ranged from $1.31
         to $4.25, and the information relating to these options was as follows:
<TABLE>
<CAPTION>

                                                                  Weighted-         Weighted-       Weighted-
                                                                   Average           Average         Average
                                                                  Remaining         Exercise        Exercise
                                 Stock             Stock         Contractual          Price           Price
              Exercise          Options           Options      Life of Options      of Options      of Options
                 Price        Outstanding       Exercisable      Outstanding       Outstanding      Exercisable
           ----------------   -----------       -----------    ---------------     ----------       -----------
           <S>                   <C>                 <C>          <C>              <C>              <C>
           $    1.31 - 1.50      257,066                 -        9.49 years       $    1.35        $        -
           $    1.51 - 4.50       37,254             7,722        6.47 years       $    4.25        $      4.25
                              -----------       -----------

                                 294,320             7,722
                              ===========       ===========
</TABLE>


                                      F-17
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 6 - SHAREHOLDERS' EQUITY (CONTINUED)

         Stock Option Plan (Continued)
         -----------------
         The Company has adopted only the disclosure provisions of SFAS No. 123.
         It applies APB 25 and related interpretations in accounting for its
         plans and does not recognize compensation expense for its stock-based
         compensation plans other than for restricted stock and options issued
         to outside third parties. If the Company had elected to recognize
         compensation expense based upon the fair value at the grant date for
         awards under this plan consistent with the methodology prescribed by
         SFAS No. 123, the Company's net loss and loss per share would be
         reduced to the pro forma amounts indicated below for the years ended
         August 31, 1999 and 1998:
<TABLE>
<CAPTION>

                                                                                 1999               1998
                                                                           ---------------    ----------------
             <S>                                                           <C>                <C>
             Net loss
                 As reported                                               $     (576,665)    $    (2,069,239)
                 Pro forma                                                 $     (595,196)    $    (2,069,239)
             Basic and diluted loss per common share
                 As reported                                               $        (0.17)    $         (0.62)
                 Pro forma                                                 $        (0.17)    $         (0.62)
</TABLE>

         The fair value of these options was estimated at the date of grant
         using the Black-Scholes option-pricing model with the following
         weighted-average assumptions for the years ended August 31, 1999 and
         1998: dividend yields of 0% and 0%, respectively; expected volatility
         of 100% and 65%, respectively; risk-free interest rates of 6% and 5%,
         respectively; and expected life of five and five years, respectively.
         The weighted-average fair value of options granted during the years
         ended August 31, 1999 and 1998 was $0.97 and $4.25, respectively, and
         the weighted-average exercise price was $1.35 and $4.25, respectively.

         For options granted during the year ended August 31, 1999 where the
         exercise price equaled the stock price at the date of the grant, the
         weighted-average fair value of such options was $1.16, and the
         weighted-average exercise price of such options was $1.50. For options
         granted during the year ended August 31, 1999 where the exercise price
         was greater than the stock price at the date of the grant, the
         weighted-average fair value of such options was $0.93, and the
         weighted-average exercise price of such options was $1.31. No options
         were issued during the year ended August 31, 1999 where the exercise
         price was less than the stock price at the date of the grant.


                                      F-18
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 6 - SHAREHOLDERS' EQUITY (CONTINUED)

         Stock Option Plan (Continued)
         -----------------
         The Black-Scholes option valuation model was developed for use in
         estimating the fair value of traded options which have no vesting
         restrictions and are fully transferable. In addition, option valuation
         models require the input of highly subjective assumptions including the
         expected stock price volatility. Because the Company's employee stock
         options have characteristics significantly different from those of
         traded options, and because changes in the subjective input assumptions
         can materially affect the fair value estimate, in management's opinion,
         the existing models do not necessarily provide a reliable single
         measure of the fair value of its employee stock options.

         Other Stock Options
         -------------------
         As of August 31, 1999, the Company granted the Board of Directors a
         total of 3,206 stock options at exercise prices ranging from $1.50 to
         $5.25.

         During the year ended August 31, 1999, the Company entered into an
         investor relations agreement for $4,000 per month and 30,000 stock
         options at an exercise price of $1.00, which equaled the fair market
         value on the date of grant. As of August 31, 1999, 15,000 of these
         options were exercisable.


NOTE 7 - RELATED PARTY TRANSACTIONS

         As of August 31, 1999, included in accrued compensation due to officer
         was $122,250, which represents accrued salary due to the Company's
         President. The amount due does not accrue interest and is included in
         the "accrued payroll and other expense" account.

         As of August 31, 1999, included in accrued compensation due to officer
         was $25,500, which represents accrued salary due to the Company's Vice
         President of Human Resources. The amount due does not accrue interest
         and is included in the "accrued payroll and other expense" account.

         In connection with the Company's stock offering, the Company agreed to
         grant to its President 300,000 warrants to purchase up to 300,000
         shares of the Company's common stock. The number of warrants to be
         granted will be based on net income for the year ended August 31, 1999,
         but cannot exceed 300,000 warrants. Since the Company did not meet the
         net income requirement, the warrants were not granted.



                                      F-19
<PAGE>

                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                                                 AUGUST 31, 1999
================================================================================


NOTE 8 - LINE OF CREDIT

         The Company has available an unsecured $100,000 revolving line of
         credit from a bank with interest payable on a monthly basis at prime
         (8% at August 31, 1999), plus 3%. The line is personally guaranteed by
         the Company's President. As of August 31, 1999, the amount drawn
         against the line of credit was $89,828.


NOTE 9 - LINES OF BUSINESS

         For internal reporting purposes, management segregates the Company into
         two divisions as follows:
<TABLE>
<CAPTION>

                                              Simulations
                                               Plus, Inc.      Words+, Inc.     Eliminations         Total
                                            --------------    --------------    -------------    --------------
             <S>                            <C>               <C>               <C>              <C>
             Net sales                      $     461,306     $   3,005,499     $          -     $   3,466,805
             Income (loss)
               from operations              $    (896,189)    $     187,142     $          -     $    (709,047)
             Identifiable assets            $   1,449,960     $     713,414     $   (552,120)    $   1,611,254
             Capital expenditures           $           -     $           -     $          -     $           -
             Depreciation and
               amortization                 $      38,660     $      41,837     $          -     $      80,497
</TABLE>

         Most corporate expenses, such as legal and accounting expenses and
         public relation expenses are included in Simulations Plus, Inc.

         Segment information is not shown for the year ended August 31, 1998
         because the Simulations software business was not material to the
         operations of the Company.


NOTE 10 - YEAR 2000 ISSUE

         The Company has conducted a comprehensive review of its computer
         systems to identify the systems that could be affected by the Year 2000
         Issue and has developed an implementation plan to resolve the Issue.

         The Issue is whether computer systems will properly recognize
         date-sensitive information when the year changes to 2000. Systems that
         do not properly recognize such information could generate erroneous
         data or cause a system to fail. The Company is dependent on computer
         processing in the conduct of its business activities.

         Based on the review of the computer systems, management does not
         believe the cost of implementation will be material to the Company's
         financial position and results of operations.

                                      F-20

                               ABSORPTION SYSTEMS

                               LICENSE AGREEMENT

THIS AGREEMENT ("Agreement") is made as of July 26, 1999 ("Effective Date") by
and between:

         ABSORPTION SYSTEMS LP ("ASLP"), a Pennsylvania limited partnership,
with its principal office at Oaklands Corporate Center, 440 Creamery Way, Suite
C, Exton, Pennsylvania 19341; and

         SIMULATIONS PLUS, INC. ("SPI"), a California corporation with its
principal office at 1220 W. Avenue J, Lancaster, California 93534.


BACKGROUND
- ----------

         A. SPI is the vendor of certain pharmaceutical development software
("SPI Software") that is sold in functional units consisting of a base unit
("Base") and optional add-on units that provide additional functionality
("Modules"). Each set of Base and Modules that are logically connected is
referred to herein as a "Package." As of the Effective Date of this Agreement,
SPI markets two Packages, one containing the "QMPRPlus" Base (the "QMPRPlus
Package") and one containing the "GastroPlus" Base (the "GastroPlus Package").

         B. ASLP is engaged in the testing of chemical compounds in drug
development ("Compounds") for membrane permeability properties and describing
those properties in numerical form ("Data"). ASLP has prepared Data for 330
Compounds ("Compounds"), which Data has been organized in a spreadsheet format
along with chemical structure information for each of the Compounds (the
"Database"). ASLP represents that the data contained in the Database were
generated through experiments conducted at ASLP in accordance with experimental
protocols and laboratory practices that would be deemed of high quality by
reputable scientists familiar with such protocols and practices. ASLP further
represents that it is the sole owner of the database and has the right to enter
into this Agreement with respect to its use without the approval of any other
party.

         C. Under this Agreement, ASLP shall give to SPI access to the Database
for use by SPI in the development of mathematical models to be incorporated into
one of the optional Modules. The intended function of this Module (the ASLP
Caco-2 "Permeability Module") will be to predict the membrane permeability
properties of other chemical structures. The ASLP Caco-2 Permeability Module is
intended to be offered as an optional module for the QMPR Plus Package. The
QMPRPlus Package may later be offered in the form of an optional Module for
GastroPlus, in which case the ASLP Caco-2 Permeability Module will be offered as
an optional sub-module within the QMPRPlus Module.

         D. The Compounds are all commonly or publicly available (" Public
Domain Compounds"). It is understood that ASLP will test and generate data for
Compounds that are the property or trade secrets of third parties ("Proprietary
Compounds"). No data relating to Proprietary Compounds will be licensed to SPI
hereunder and no such Data will be incorporated into the Modules.

         E. The parties are contemplating forming a joint venture pursuant to a
definitive joint venture agreement that is yet to be negotiated (the

<PAGE>

"Prospective Joint Venture"). The Prospective Joint Venture shall be deemed
outside the scope of and separate from this Agreement, except as otherwise
expressly provided for in the definitive joint venture agreement. If the
Prospective Joint Venture is formed, the parties anticipate that ASLP will
license the bioavailability data relating to certain Proprietary Compounds to
it.

TERMS
- -----

         In consideration of the above recitals (which are deemed a material
part of this Agreement) and the grant, payments and mutual agreements set forth
herein, and intending to be legally bound hereby, the parties hereto agree as
follows:

1.      DEFINITIONS

In addition to the terms defined elsewhere in this Agreement, the following
terms shall have the following meanings.

         1.1. "Affiliate" shall mean, with respect to a particular party hereto,
any entity that (i) owns more than 50% of the outstanding voting securities or
similar interests of such party, (ii) more that 50% of whose outstanding voting
securities or similar interests are owned by such party or (iii) more than 50%
of whose outstanding voting securities or similar securities are owned, directly
or indirectly, by another entity that also owns, directly or indirectly, more
than 50% of the outstanding voting securities or similar interests of such
party.

         1.2. "Base" shall mean a unit of Software that is available for license
to SPI's users, and which may be used with Modules. A Module may not be used
without a Base, but a Base may be used without a Module.

         1.3. "Confidential Information" shall mean the proprietary and trade
secret information of the parties as stated in this Agreement.

         1.4. "Hardware" shall mean computer equipment that is capable of
running or operating Software.

         1.5. "Net Sale Price" shall mean gross revenues received by SPI or any
Affiliate from a non-Affiliate third party attributable to the Sale of any SPI
Software Package in which an ASLP Module is bundled or the Sale of any Base unit
with which an ASLP Module is marketed and any services provided in support or in
connection with such Package or Base unit, less qualifying costs directly
attributable to such Sales and actually allowed, identified on the invoice or
other documentation and borne by SPI. Such qualifying costs shall be limited to
the following: (i) discounts in amounts customary in the trade for quantity
purchases, cash payments, prompt payments and for wholesalers and distributors;
(ii) credits or refunds, not exceeding the original or customary billing or
invoice amount for claims or returns; (iii) prepaid transportation insurance
premiums; (iv) prepaid outbound transportation expenses; and (v) sales, value
added and use taxes imposed by a government agency on SPI related to such Sales.

         1.8. "Sale" shall mean a transaction in which consideration is received
by SPI regardless of whether the transaction is classified as a license, a sale,
a use, a rental agreement, or other type of transaction, and shall be effective
upon the first occurrence of any of the following with respect to any of the
Software in question: (a) SPI receives partial or full payment for an order that

<PAGE>

includes such Software, (b) SPI ships part or all of an order that includes such
Software, or, (c) SPI books an order that includes such Software.

         1.9.  "SPI Software" shall mean Software owned by SPI.

         1.10. "Software" shall mean computer programs and related
               documentation.

2.      LICENSE GRANT; RESTRICTIONS; OTHER INTELLECTUAL PROPERTY CONCERNS

         2.1. ASLP hereby grants to SPI a non-exclusive, worldwide license to
use the Data, including the Data contained in the Database for the exclusive
purpose of developing or enhancing mathematical models to be incorporated into
the Permeability Module.

         2.2. This license shall not include the right to sublicense the Data to
any third party.

         2.3. Except where the parties agree in a document signed by both
parties, SPI may not distribute any Data or any part of the Database to any
third parties under any circumstances, nor may SPI allow any third parties to
have any access to any Data or any part of the Database. Under no circumstance
may any Data or any part of the Database be copied or distributed to any users,
distributors, independent contractors, or any entity other than SPI and ASLP.
For further clarification, no Base unit or Module will contain any Data in any
version. Rather, the Data will be used for creating, developing, improving or
enhancing SPI's mathematical models, but will not be accessible in any Base unit
or Module.

         2.4. ASLP may place its copyright and proprietary rights notices on the
Data and Database. SPI shall preserve ASLP's notices on the Data and Database.
However, the placing of any copyright notice shall not be deemed a publication
or placement in the public domain.

         2.5. In all agreements with its licensees, customers and/or users, SPI
shall prohibit such persons from reverse engineering the Permeability Module or
otherwise attempting to recover or recreate any Data or other information from
such Module.

         2.6. The license granted hereunder will terminate upon termination of
this Agreement, regardless of the reason for termination. Upon termination
hereof, SPI shall cease using the Data and Database and shall cease making,
distributing, selling or otherwise using any derivative work of such Data,
including without limitation the Permeability Module. Termination of SPI's
license to use Data and Database shall not terminate the rights of SPI's
licensees to use the Permeability Module so long as SPI's licensees continue to
adhere to the terms of their respective written license agreements with SPI.

3.      ROYALTIES AND ACCOUNTING

         3.1. In consideration of the license granted hereunder, SPI shall pay
to ASLP a royalty on the Sale of each ASLP Caco-2 Permeability Module an amount
equal to 50% of the Net Sale Price of such Module. ASLP alone will determine the
sale price of the ASLP Caco-2 Permeability Module.

         3.2 The above royalty rates have been agreed to by the parties with the
understanding that SPI will collect a Net Sale Price in the amount of $20,000
per Base and $30,000 per ASLP Caco-2 Permeability Module. Unless otherwise
authorized by ASLP in writing, SPI will not materially change the prices of the
ASLP Caco-2 Permeability Module.

<PAGE>

         3.3. SPI will provide a statement and pay all royalties to ASLP by the
30th day following the end of each SPI fiscal quarter (ending November 30,
February 28/29, May 31 and August 31) for all Sales during such quarter. The
statement will be provided to ASLP regardless of whether any royalty is due, and
will include the date of each Sale, the name and address of each buyer, the
distributor or other person making the sale if other than SPI, a list of each
Base, Module, Package, or other items included with the sale, and the amounts to
be paid.

         3.4. SPI agrees to maintain records of all transactions contemplated by
this Agreement in accordance with its customary business practices. ASLP shall,
at its sole expense and with auditors of its choice, be entitled to audit and
examine the records maintained by SPI in connection with the transactions
contemplated by this Agreement. The audits shall be made at SPI's site during
customary business hours and upon reasonable prior written notice. ASLP shall be
entitled to conduct no more than two audits per calendar year. ASLP may make
copies of financial records of SPI reflecting transactions directly relating to
any activities arising under this Agreement. Any such audits shall be paid for
by ASLP, except that SPI shall reimburse ASLP for the cost of an audit if the
audit shows that SPI owes ASLP 2.5% or more in royalties than SPI had accounted
for with respect to the period since the previous audit by ASLP or the beginning
of this Agreement if there was no prior audit. ASLP agrees that all information
learned as result of such audit is SPI's Confidential Information under the
confidentiality provisions of this Agreement.

         3.5. Any amounts not paid within thirty (30) days of the due date shall
be subject to late fees in the amount of 1.5% of outstanding amounts for such
period, compounded monthly.

4.    CONFIDENTIALITY

         4.1. Each party shall reveal to the other party only the Confidential
Information that is necessary, if any, for the other party to perform its tasks
or uphold its responsibilities hereunder. The parties' respective Confidential
Information may include business plans and proprietary technology not made
available to the general public.

         4.2. All Data, the Database, the Mathematical Models, and Source Code
are automatically deemed to be Confidential Information and do not need to be
marked as such. All other types of Confidential Information should be clearly
marked "Confidential" or "Proprietary," but the parties recognize that most such
Confidential Information is known by the parties to be Confidential Information
in accordance with the nature of the information so disclosed. By way of
example, all business plans, sales forecasts and discussions of new products
shall be deemed Confidential Information and do not need to be marked as such.

         4.3. Each receiving party shall hold the Confidential Information in
confidence and shall use the highest level of care to prevent any unauthorized
use or disclosure of it. Neither receiving party shall use the Confidential
Information of the other for any purpose, except as contemplated hereunder. Each
receiving party shall allow the disclosure of the Confidential Information of
the other party only to such of its employees and independent contractors and
those of its Affiliates who have a need to know such Confidential Information in
the performance of their legitimate job responsibilities in connection with the
use of such information as contemplated by this Agreement. Each receiving party
will take reasonable steps to cause each such employee or independent contractor
to abide by the confidentiality and non-use obligations imposed hereunder and
will be responsible for any breach by such employees or independent contractors
of such obligations.

<PAGE>

         4.4. Each receiving party agrees to use appropriate confidentiality
protocols, which shall include no less than numbering and keeping an up-to-date
log of each copy of Confidential Information, and requiring that each employee
of a receiving party who has access to a hard copy or soft (i.e., electronic)
copy of such Confidential Information sign out and sign in such copy.

         4.5. The confidentiality obligations of this Agreement shall not apply
to information that (i) at the time of disclosure is in the public domain, or
(ii) information which becomes part of the public domain by publication or
otherwise, except by any breach of this Agreement, or (iii) information which
has been or is intentionally disclosed by the disclosing party to the public or,
without restriction (i.e., confidentiality protections), to a third party. In
the event that a court or governmental agency requests or demands that a
receiving party disclose the Confidential Information of a disclosing party, the
receiving party shall not be liable for making such a disclosure if the
receiving party immediately notifies the disclosing party and reasonably
cooperates with the disclosing party in any attempt to seek injunctive relief or
other relief, provided, however, that such disclosure will not otherwise relieve
the receiving party subject to such court or governmental request or demand from
its continuing confidentiality and non-use obligations hereunder with respect to
all of the disclosing party's Confidential Information, including the
information disclosed to the court or governmental agency under this sentence.

         4.6. The confidentiality obligations under this Agreement shall survive
termination of this Agreement and shall have no expiration date.

5.      WARRANTIES

         5.1. SPI warrants that it will use its best efforts to sell the ASLP
Caco-2 Permeability Module. ASLP warrants that it will use its best efforts to
promote and assist in the sale of the ASLP Caco-2 Permeability Module.

         5.2. Each party warrants to the other that it has the right to enter
into and be bound by this Agreement.

         5.3. Each party warrants to the other that its performance of this
Agreement shall not cause or create a breach of any other contract or agreement
to which it is bound.

         5.4. Each party ("Indemnitor") agrees to indemnify the other party
("Indemnitee") for any claims brought against the Indemnitee allegedly arising
out of the actions or omissions of the Indemnitor, including without limitation
any claims of violation of any intellectual property or other rights of a third
party. Indemnification under this Agreement is conditioned on prompt written
notice of any claim, action, or demand for which indemnity is claimed; complete
control of the defense and settlement thereof by the Indemnitor; and cooperation
of the Indemnitee in such defense. Should the Indemnitee wish to participate in
defense of the claim, it shall do so at its own expense after the Indemnitor
assumes control of the defense.

6.      DISCLAIMER OF WARRANTIES AND LIMITATION OF LIABILITY

         6.1. THE EXPRESS WARRANTIES GIVEN IN SECTION 5 OF THIS AGREEMENT ARE
GIVEN IN LIEU OF ALL OTHER EXPRESS AND IMPLIED WARRANTIES, INCLUDING BUT NOT
LIMITED TO ANY IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A
PARTICULAR PURPOSE, AND ARE THE ONLY WARRANTIES MADE WITH RESPECT TO THE
TRANSACTIONS CONTEMPLATED HEREBY.

<PAGE>

         6.2. ASLP shall in no event be liable for any loss of profit or
goodwill, or other indirect, special, consequential or incidental damages
suffered by SPI or others. SPI shall in no event be liable for any loss of
profit or goodwill, or other indirect, special, consequential or incidental
damages suffered by ASLP or others.

         6.3. ASLP's liability for direct damages to SPI or others shall not
exceed the amount actually received by ASLP from SPI for the specific
Permeability Module licensed to a third party that is the subject matter of the
alleged damages. SPI's liability for direct damages to ASLP or others shall not
exceed the amount actually received by SPI from sales of the specific
Permeability Module licensed to a third party that is the subject matter of the
alleged damages.

7.      TERM AND TERMINATION

         7.1. This Agreement is effective as of the Effective Date, and shall
continue for an initial term of one (1) year, and shall automatically renew for
periods of one (1) year each.

         7.2. This Agreement may be terminated by either party by sending
written notice that is received by the other party no less than three (3) months
prior to the end of the then current term.

         7.3. Failure by any party to comply with any term or condition under
this Agreement ("defaulting party") shall entitle the other party
("non-defaulting party") to give the defaulting party written notice of such
default. If the defaulting party has not cured such default within 30 days of
the date of the notice, the non-defaulting party shall be entitled to terminate
this Agreement effective immediately upon sending of written notice. The rights
under this provision are in addition to all other rights the non-defaulting
party may have, and the failure to enforce such rights shall not be deemed to be
a waiver of those rights.

         7.4. In the event of termination of this Agreement, SPI shall
immediately thereafter cease all use of the Data and Database and return to ASLP
or destroy all copies of the Data and Database in SPI's possession or under its
control (and certify to ASLP that it has done so), and ASLP shall return to SPI
or destroy all copies of any information relating to Mathematical Models, Source
Code, Marketing Information, or other information of a similar nature in ASLP's
possession or under its control (and certify to SPI that it has done so) unless
SPI shall have provided written permission for ASLP to retain such information.

         7.5. Any termination of this Agreement shall not terminate the
responsibilities to pay any monies due or owing.

8.      GENERAL PROVISIONS

         8.1. Neither party may assign this Agreement and any licenses
hereunder, without the prior written agreement of the other party, which may be
withheld by such party in its sole discretion and for any reason. This Agreement
shall be binding upon the parties and their heirs, successors and permitted
assigns.

         8.2. This Agreement shall be governed by and construed in accordance
with the laws of the Commonwealth of Pennsylvania. The parties hereby consent to
the jurisdiction of any court located in the Commonwealth of Pennsylvania to
hear any controversy arising under this Agreement and hereby waive any claim or
objection to such forum based on inconvenience, provided the location and time
of such hearings allow the parties to make reasonable arrangements to attend
such hearings.

<PAGE>

         8.3. The parties to this Agreement are independent contractors. Neither
party under this Agreement shall be deemed an employee or employer of the other.
Neither party shall have the right to control the employees or agents of the
other. This Agreement shall not be construed as a partnership agreement, and the
parties to this Agreement are not partners. Except as to certain rights
otherwise set forth herein, this Agreement is not exclusive to either party.
Neither party has authority to enter into agreements on behalf of the other.
Neither party is authorized to bind the other in any way. Each party shall be
solely responsible for its own employees, including the withholding of taxes and
payment of any benefits for such employees.

         8.4. If any of the provisions of this Agreement are declared to be
invalid or unenforceable, such provisions shall be severed from this Agreement
and the other provisions shall remain in full force and effect.

         8.4. This Agreement is solely between the parties to this Agreement.
This Agreement may not be construed to create any third-party beneficiary rights
in any other individual, partnership, corporation, or other entity.

         8.6. All provisions of this Agreement that provide rights or create
responsibilities for the parties after termination of this Agreement shall
survive the termination of this Agreement for any reason. Such provisions that
survive termination include without limitation provisions regarding payment,
confidentiality, intellectual property, choice of law and this provision.

        IN WITNESS WHEREOF, the parties, intending to be legally bound, have
caused this Agreement to be executed by their duly authorized agents, as of the
date first written above.

ABSORPTION SYSTEMS LP

BY:  ABSORPTION SYSTEMS GROUP LLC
     ITS GENERAL PARTNER


By:  /s/ Patrick M. Dentinger
     ----------------------------------
Patrick M. Dentinger, President & CEO


SIMULATIONS PLUS, INC.
ITS CHAIRMAN AND CHIEF AND CHIEF EXECUTIVE OFFICER


By:  /s/ Walter S. Woltosz
     ----------------------------------
Walter S. Woltosz, Chairman, President & CEO


                               THE KRIEGSMAN GROUP

January 8, 1999

CONFIDENTIAL

Mr. Walter Woltosz
President and CEO
Simulations Plus, Inc.
1220 W. Avenue J
Lancaster, California 93534

                   RE: SIMULATIONS PLUS, INC. (THE "COMPANY")

Dear Mr. Woltosz:

This will confirm our understanding that the Company has agreed to retain the
services of The Kriegsman Group ("Kriegsman") to render advice and assistance to
the Company with respect to planning, structuring, and funding a proposed
financing by the Company (hereinafter referred to as the "Financing") as
described below.

The Financing shall consist of:

         Up to $25 million, preferably in the form of common stock or
         convertible preferred stock.

Kriegsman shall have the exclusive right for a period of 180 days, or any
extension thereof as provided for herein (the "Term") from the date this letter
is signed by you to accomplish the Financing and during that period will use its
best efforts to do so. Kriegsman agrees to use his best efforts to raise a
minimum of $1.2 million within 60 days. The Company will have the option of
terminating this agreement at any time after 60 days if such financing is not
completed within 60 days. Specifically, Kriegsman's efforts will include:

     *  Assisting in the review and revision of offering documents;

     *  Identifying and contacting prospective lenders/investors;

     *  Assisting in the presentation of the Company to financing sources;

     *  Analyzing offers and contacting prospective lenders/investors;

     *  Assisting with closing the financing as soon as practicable.

If (i) the Financing or (ii) any part thereof, or (iii) any other Capital
Transaction, as that term is defined herein, (the events described in (i), (ii)
or (iii) are collectively referred to herein as a "Fee Event") is concluded or

<PAGE>

contractually committed to within the Term the Company will pay Kriegsman a fee,
in cash, calculated:

         (i) if equity including any convertible securities, six percent (6%) of
         all funds raised or committed, or

         (ii) if debt, three percent (3%) of all senior debt and six percent
         (6%) of all subordinated debt raised, or

         (iii) if not debt or equity, then seven percent (7%) of the value of
         the consideration received by the Company.

Kriegsman's fee shall be due and payable upon the closing of the Fee Event. If,
after the Term and prior to the expiration of one year from the conclusion of
the Term, a Fee Event occurs, where the provider of funding is a person or
entity Introduced to the Company by Kriegsman or under the control of or
Introduced to the Company by a person or entity Introduced to the Company by
Kriegsman, then in that event Kriegsman shall be entitled to a fee on the same
terms and conditions as set forth above. As used in this letter the term
"Capital Transaction" shall mean any issuance or sale of securities or issuance
of debt, any lease transaction (not including routine equipment leases), any
acquisition, merger, sale, strategic alliance or partnership or any other
transaction in which the Company or its shareholders receive consideration or
funding out of the ordinary course of business. At the conclusion of the Term,
Kriegsman shall provide to the Company a list of all persons or entities
Introduced to the Company by Kriegsman. The term "Introduced" with respect to
any investor as used herein shall include Kriegsman sending a copy of the
Company's business plan to such investor. The Company agrees to inform Kriegsman
of any Fee Event which occurs during the Term and for one year thereafter.

For the services provided, the Company shall pay Kriegsman $6,000 on the
execution hereof and $6,000 per month in advance on the seventh (7th) day of the
month for five (5) consecutive months beginning February 7, 1999 and continuing
each month thereafter during the term hereof including any extension of the term
hereof. Such sum shall be credited against amounts due Kriegsman at the closing
of a fee event. In the event the Financing or other Fee Event does not occur,
the retainers paid by the Company are non-refundable.

In addition to the above referenced consideration Kriegsman shall receive at the
closing of any Fee Event in which he is entitled to the cash fee described above
a warrant to purchase 50,000 shares of the common stock of the Company for each
one million dollars received by the Company in any such fee event. The exercise
price shall be 120% of the fair market value of the common stock at the time the
warrant is issued, with the presumption that the Last Sale Price (the price paid
by the investor) represents such fair market value unless the Company shall
propose some other market value based upon reasonable proof that such other
value is more appropriate. The warrant shall be exercisable over a five year
period and shall contain clauses standard to an underwriter's warrant used in
connection with a registered public offering of securities. The Company agrees
to reserve a sufficient amount of its common stock to cover the exercise of the
warrant.

<PAGE>

The Term hereof shall automatically be extended for successive periods of 60
days each unless prior to the end of initial Term or any extension thereof
either party gives written notice to the other of their intention not to extend
the term hereof.

In addition to the fees described above, the Company will reimburse Kriegsman
for reasonable out-of-pocket expenses incurred by Kriegsman in raising the
financing. Expenses in excess of $500 per month must be pre-approved by the
Company. The Company agrees to indemnify and hold harmless Kriegsman from and
against any and all losses, claims, damages, liabilities, judgments, charges and
expenses (including all legal or other expenses reasonably incurred by
Kriegsman) in connection with investigating or defending against or providing
evidence in any litigation, whether commenced or threatened, in connection with
any claim, action or proceeding whether or not resulting in any liability, to
which Kriegsman may become subject under any other statute, at common law or
otherwise, caused by, or arising out of any service under this agreement,
provided, however, that the Company shall not be liable in any such case to the
extent that any such loss, claim, damage or liability is found in a final
judgment by a court to have resulted from Kriegsman's gross negligence, willful
misconduct or malfeasance. Kriegsman shall be entitled to employ counsel
separate from the Company and from any other part in such action. In such event,
the reasonable fees and disbursements of such separate counsel, as incurred,
shall be paid by the Company. If the Company or its officers, directors,
shareholders or affiliates suffer or incur any loss, claim, damage, liability or
expense by reason of Kriegsman's gross negligence, willful misconduct or
malfeasance, the Company and any such persons have the same rights of
indemnification from Kriegsman as are given by the Company to Kriegsman
hereunder.

This agreement constitutes the entire agreement between us, and it may not be
modified except in writing signed by all parties hereto. This agreement shall be
governed by and construed in accordance with the laws of the State of
California. Any dispute arising from the interpretation, validity or performance
of this agreement or any of its terms and provisions shall be submitted to
binding arbitration before the American Arbitration Association in the State of
California. Should action be brought to enforce this agreement, the prevailing
party shall be entitled to recover from the other reimbursement for reasonable
attorney's fees.

If the foregoing meets with your approval, please sign and date the enclosed
copy of this letter and return it to the undersigned.

Sincerely,                              AGREED:

THE KRIEGSMAN GROUP                     SIMULATIONS PLUS, INC.

By: /s/ Steven A. Kriegsman             By: /s/ Walter Woltosz
    -----------------------------------     -----------------------------------
        Steven A. Kriegsman/President           Walter Woltosz/President and CEO
        Date: 01/08/99                          Date: 01/11/99
SAK:krh
c:  Jack Myers


                              Banchik & Associates
                    Consultants to Emerging Public Companies



November 9, 1998

Mr. Walt Woltosz
Chairman and Chief Executive Officer
SIMULATIONS PLUS, INC.
1220 West Avenue J                            RE: LETTER OF ENGAGEMENT
Lancaster, CA 93534-2902                      Commencement of Investor Relations
                                              ----------------------------------


Dear Mr. Woltosz:

We are preparing to embark upon a program of investor relations activities on
behalf of Simulations Plus, Inc. "The Company". By separate cover and
documentation previously submitted, entitled "Investor Relations Engagement
Proposal", dated November 6, 1998, we have detailed our intended activities. The
ultimate objective of such Program is to achieve an efficient market for The
Company's securities, thereby contributing to shareholder liquidity.

We propose that the official commencement date of our activities be November 15,
1998, subject to the acceptance of the terms outlined herein and our receipt of
the agreed funds. In this relationship, Banchik & Associates agrees to comply
fully with all securities regulations, industry guidelines and applicable laws.
Additionally, our firm shall maintain the confidentiality of all information of
the Company that has not been cleared by the Company for public release.

The Company agrees to indemnify, defend (if requested by Banchik & Associates,
and then with counsel reasonably acceptable to Banchik & Associates) and hold
Banchik & Associates, including its shareholders, officers and employees,
harmless from and against any and all losses, claims, damages, expenses or
liabilities which Banchik & Associates may incur as the result of the
performance of its obligations and duties under this engagement letter with the
exception, however, of any matter arising from the negligent acts of Banchik &
Associates.

The Company agrees that it shall be deemed to have cleared all press releases,
reports or other information which are prepared by Banchik & Associates but
disseminated to the public by the Company. The Company agrees that all
information, representations, reports or data furnished by it to Banchik &
Associates for its use in connection with the services to be performed by it
under the engagement letter shall not include any material misstatement of a
material fact, or omit to state any material fact, necessary for the services to
be performed by Banchik & Associates to not be misleading under the
circumstances under which such services are provided.

To commence with the above mentioned investor relations program, as described in
detail in the "Investor Relations Engagement Proposal" dated November 6, 1998,
we respectfully request that you accept this engagement by signing below and
facilitate the initial payment for our receipt on or before five days prior to
the commencement of this engagement. Pursuant to the Budget section in the
Proposal, the initial payment shall include the fees ($2,000.00) for the last

<PAGE>

half of the month of November 1998. In addition, the signed letter of engagement
should be returned with the stock option/stock appreciation rights grant
conforming to that proposed in the Budget section in the Investor Relations
Engagement Proposal, dated November 6, 1997. In the event that this grant cannot
be issued within the time frame required for the commencement of the engagement,
we request that a letter be sent indicating that a conforming grant will be
forthcoming within 90 days of the commencement of the engagement.

The Company will be billed on the first of each month thereafter the sum of
$4,000.00 for professional fees plus itemized expenses incurred the previous
month as described in the Investor Relations Engagement Proposal dated November
6, 1998. These invoices are due within ten (10) days of receipt. Commitments to
venders and others outside of Banchik & Associates for the purchase of goods and
services related to our carrying out the subject activities will first be
approved by The Company.

Either party may terminate this engagement by providing one month's written
notice to the other and delivering same by registered mail.

Should the terms outlined herein meet with your approval, please sign and enter
the date as provided below. Retain a copy for your files and send an original
and a check in the amount of $2,000.00.

On behalf of my associates and myself, I wish to thank you for your confidence
in us and for retaining our firm. We look forward to working with you now and in
the future toward mutually beneficial goals.



Respectfully submitted,
Banchik & Associates

/s/ Doris Banchik
- --------------------------
Doris Banchik
Principal



Accepted for
SIMULATIONS PLUS, INC.


/s/ Walter Woltosz
- --------------------------
Walt Woltosz                                       Date
Chairman and Chief Executive Officer

<PAGE>

                              Banchik & Associates
                    Consultants to Emerging Public Companies
                         686 Alamo Pintado Road, Suite B
                            Solvang, California 93463



Telephone: (805) 688-2340                                    Fax: (805) 688-4090
- --------------------------------------------------------------------------------



November 6, 1998

Mr. Ron Creeley, Vice President
Simulations Plus, Inc.
1220 West Avenue J
Lancaster, CA 93534                   RE: INVESTOR RELATIONS ENGAGEMENT PROPOSAL


Dear Ron:

It was truly a great pleasure to meet with you and Walt on Tuesday. You have a
compelling story with real promise and I would be delighted to work with you in
creating an efficient market for your securities.

As discussed in our meeting, I genuinely believe that your story and investment
appeal is buried in your current investor relations materials and as such is
creating no value for you. In addition, I think that the Company would benefit
from casting the pharmaceutical software business as a biotech play of sorts and
definitely the lead dog among your businesses. In this way the Company's
near-term valuation will not be subject to the "sale" of software, which at
$20,000 per sale, is not the kind of event about which the Street would get
excited. As a biotech type story, the focus is on the size of the potential
market and your unique advantage in capturing that market; your sales then
become a proxy for your credibility among the large pharmaceutical houses. That,
in any event, is my recommendation. Certainly if you make a profit, the
investors will be pleased, but as with any groundbreaking product, you might be
better off tying your valuation to longer-term promise.

Another reason for taking the "biotech" route is that the market for aggressive
growth securities under $5.00 is very limited. I have noticed that the small
caps are coming back into favor, but slowly and with caution. As a biotech type
play, your market cap and revenue become less important than your cash flow,
which for Simulations Plus, would be a positive. I would be less enthusiastic
about your near term prospects as an aggressive growth story.

I understand that your current objective is to increase liquidity in the
Company's stock in an effort to improve the Company's access to reasonably
priced capital. It is with this objective in mind that I submit my proposal for
investor relations consulting services. As requested, I have prepared a detailed
three-month plan and an associated budget. The budget assumes that the day to
day investor relations work will continue to be handled by the Company's support
staff. You have also requested that I submit a budget based on your staffing an
investor relations position as well. I have offered you some guidance in that
regard, but could not be specific without knowing the qualifications of the
individual.

<PAGE>

The investor relations effort that I am recommending should begin with a very
thorough analysis of the business and the path to building shareholder value. As
discussed, we need to identify that which is being exploited by the Company in
building value. This exercise should conclude with a concise and compelling
investment thesis, a set of reasonable expectations, and an internal earnings
model. This work would then be used to create certain investor communications
tools, including a professional corporate profile, two levels of presentation
and, a compelling investor package. The investment thesis then becomes the guide
for all communications between the Company and the Street, including press
releases, letters to shareholders, annual reports and oral communications.

A second set of tasks to be accomplished in the preliminary phase focuses on
determining the perceptions of the current investors. This is accomplished by
telephone inter-view and generally provides important information for future
communications. Existing investors are often a very good source of new buying.

With the foundation tasks completed, the investor relations' work would focus on
getting the story out to the right audience. I would begin with a mailing to a
target list of investors in early stage pharmaceuticals and biotech companies.
The preliminary list would include at least I 00 names. The mailing would be
followed up by telephone contacts. At that point, much of the work would involve
setting up meetings with the investment community, including brokers, small
institutions and analysts.

On an ongoing basis, I am recommending that your investor relations program
include the drafting or refining of all standard investor relations materials,
which are always subject to management approval. This would include, but not be
limited to all press releases, letters to shareholders, sections of the annual
reports, the MD&A of 10Q's and 10K'S. In addition, we would handle phone calls
from professional investors.

Lastly, I will advise you on matters ranging from business strategy to corporate
finance. In my experience, this function often proves to be the most valuable
and separates the real investor relations professionals from the rest of the
pack.

In the pages that follow, I have defined the scope of services that I would
provide as your consultant. You will find a section describing my experience and
a budget for your program towards the end of this document. Please know that I
would be privileged to be your consultant and have great confidence in our
ability to do great work together. Thank you for your consideration.

A WORD ABOUT BANCHIK & ASSOCIATES

Banchik & Associates works in a distinctive, exclusive partnership with its
clients. This model allows us to customize our activities to the specific needs
of clients at any point in time. Quite often we assume a counseling role,
particularly when it comes to raising capital, dealing with untoward events and
considering strategic options. Our practice is intentionally limited to a small
number of very promising clients. In this way, we can work intensively with
companies that can truly benefit from our involvement. This strategy has helped
build our excellent reputation for client service and for bringing credible
investments to the professional investment community.

Our experience in sell-side equity research and investment banking sets us apart
from most other investor relations firms and has proven invaluable to emerging
public companies. We understand how the professional investor and financial
analyst make decisions, and we use this wisdom effectively in our client work.
We have both the database and critical personal relationships within the
investment community to provide our clients with an effective and efficient
investor relations program.

<PAGE>

SCOPE OF SERVICES


The specific responsibilities and deliverables associated with this proposal
include:

         I. SETTING THE FOUNDATION (WEEKS ONE THROUGH SIX).

            *     Develop the investment thesis through an analysis of the
                  business, industry and peer group - week one.

            *     Develop or modify management presentations for specific
                  segments of the investment community, including brokers,
                  analysts and institutional investors competed by week six.

            *     Produce a comprehensive corporate profile including
                  Simulations Plus' investment thesis, business description,
                  strategy, progress and milestone trajectory or 12 month
                  expectations - completed draft by week four.

            *     Create/expand/edit target mail and fax lists of current and
                  prospective investors, investment advisors, financial analysts
                  and financial news editors, by reviewing and analyzing the
                  Company's existing lists and adding appropriate names from our
                  data base and peer group investors completed by week three.

            *     Audit ACT profile for investor relations purposes - completed
                  by week four.

            *     Prepare a compelling set of sample investor packages -
                  completed by week six.

            *     Conduct a perception study of current investors (est. 10-15 in
                  sample) completed by week three.

         II. EARLY PHASE STREET WORK (WEEKS SEVEN THROUGH TWELVE).

            *     Conduct target mailing (at least 100 names) - week seven

            *     Follow-up telephone contact - weeks seven through nine

            *     Investor meetings - estimate six, based on response to
                  mailings and managements availability

         III. ONGOING ACTIVITIES. THESE ACTIVITIES ARE PERFORMED THROUGHOUT THE
ENGAGEMENT.

            *     Scheduling roadshows and meetings for the Company's management
                  with appropriate investors and investor groups - average three
                  per month.

            *     When appropriate, establishing and producing regular investor
                  conference calls;

            *     Providing market intelligence and market research to effect
                  the positioning of the company;

<PAGE>

            *     Preparing the Company's financial press releases, quarterly
                  reports to shareholders, sections of the annual reports,
                  sections of the SEC filing documents and other marketing
                  materials;

            *     Updating investor information packages;

            *     Providing advice, counsel and support to management with
                  regard to business strategy, financings, event presentation
                  and related investor relations matters.


         IV.  BUILDING THE INTERNAL INVESTOR RELATIONS' CAPABILITY

         These activities are performed in the interest of ultimately bringing
         the investor relations program in-house. The decision to do this varies
         with each client, but it is the intention of Banchik & Associates to
         support its clients in this effort from the beginning of the
         engagement.

            *     Providing detailed  descriptions of the technology and
                  procedures behind our investor  relations' practice to the
                  senior investor relations officer;

            *     Drafting detailed procedures for each and every investor
                  relations' function;

            *     Educating the in-house personnel about the capital markets and
                  regulations;

            *     Training the personnel to perform the required activities.

ACTIVITY AND PRODUCT DETAILS

1. Investment thesis:
- ---------------------
This is developed as the core component of investor communications. Effectively,
it is a well-developed argument for investing in the Company's securities. The
investment thesis describes I the inefficiencies being exploited by the Company,
relevant market forces and near-term business strategies. The investment thesis
should be written within the first month of the engagement.

2. Corporate profile:
- ---------------------
The corporate profile is a very important written product for potential
investors. It includes the investment thesis and appeals, a description of the
Company's business, strategy and market, a twelve-month business plan and
financial highlights. The corporate profile should be written within the six
weeks of the engagement and updated quarterly thereafter.

3. Investor meetings and road shows:
- ------------------------------------
These meetings and days of meetings are designed to maximize the use of both
management's time and expense. The contacts for these meetings have been
researched and appear to be appropriate candidates for investment in the
Company. Unless specifically directed otherwise, these meetings are conducted on
a one-to-one basis or on an in-house brokerage basis. The meetings are often
scheduled to coincide with management's travel plans.

<PAGE>

4. Targeted Mailings with Follow-up Telephone Contact:
- ------------------------------------------------------
These mailings generally consist of the corporate profiles, but might include
the Annual Report, selected press releases and 10Qs and media coverage. The
target lists are carefully researched to include appropriate investment
professionals and the media. Preliminarily, we recommend one targeted mailing
every four months. As an adjunct, we might offer high volume producers the
opportunity to follow-up with targeted small institutions.

5. Market Intelligence Reports:
- -------------------------------
Market intelligence reports focus on a predefined peer group and include a
summary and analysis of news, trading volumes, market makers, institutional
holders and valuations. The reports conclude with specific recommendations drawn
from an analysis of these data. Preliminarily, we recommend one report per
six-month period.

6. Perception Study:
- --------------------
A perception study generally provides important information about the investor's
perceptions of the current and projected value of the Company, management's
effectiveness and the quality of both the business and investor relations
program strategy. Additionally, these studies can provide explanations for
changes in trading activity and the need for shifts in the investor relations'
program. The study is conducted through in-depth interviews with selected
investors and analysts and might include individual interviews with the
company's management. We recommend that this study be conducted twice a year.

7. Preparation of Recurring Written Investor Communications Materials:
- ----------------------------------------------------------------------
This includes all of the recurring written investor communications materials,
including, but not limited to: press releases, quarterly reports to
shareholders, corporate profiles (updated one time per quarter) and selected
sections of the annual report, 10Q's and 10Ks.

8. Management of the Mail, Fax and, if appropriate, Conference Call Lists:
- --------------------------------------------------------------------------
This process begins with updating the existing mail, fax and conference call
lists. The lists will be expanded to include peer group holders, new contacts,
potential analysts and relevant media. The lists will be maintained at the
Company, with input from our offices.

9. General Investor Contact:
- ----------------------------
We are prepared to handle investor calls with referral to management as needed.
A monthly list of contacts will be forwarded to management. In addition, we
propose to develop a list of key investors, who should be contacted proactively
by either our office or the client.

10. Counseling:
- ---------------
This is often a vital function of our program. The range of issues is quite
broad, but might include such things as the management of earnings estimates,
crisis management, business strategy and capital structure. The latter is an
issue that arises in the course of most engagements, and often involves the
recruitment of appropriate investment bankers.

BUDGET

         In the program described above, we have tried to respond to your
specific needs and have endeavored to provide a realistic set of activities that
take into account the status of the Company, its current investors and the
market.

         The budget for the proposed program would be $4,000 per month, plus a
stock options or stock appreciation rights program. The proposed options or
stock appreciation rights would be granted and vest as: initial grant of 40,000

<PAGE>

options/stock appreciation rights, priced at market on the first day of the
engagement; vesting at a rate of 5,000 per quarter at the beginning of the
period. The options/stock appreciation rights should have an exercise period of
five years. Banchik & Associates would be entitled to the vesting of the entire
grant upon a 50% or greater change in client ownership during the course of the
engagement.

         The budget as described above could be modified in the event that you
provide more of the proposed services in-house. While the precise reduction
would be based on the individual's qualifications and responsibilities, the
lowest end of the range for our services would be $3,000 per month, with a 50
percent reduction in the grant of options or stock appreciation rights.

         In addition to our basic fees, you will be charged monthly for direct
expenses incurred in the delivery of your program. These expenses will be billed
at cost with no processing charges added. The expenses include, but are not
limited to, mail, fax, telephone, wire services, data retrieval, conference
calls and other dedicated out-of-pocket expenses. The most significant expenses
are generally travel related for scheduled out-of-town meetings. Any unusual
expenses are subject to management's approval. Generally our clients find that
monthly expenses, short of travel or other big ticket items, run approximately
$150.00 per month.

         Our procedure is to bill on the first of the month, with accumulated
direct expenses for the previous month. In exchange for our unusual policy of
not adding a processing fee, we ask that the invoice be paid within 10 days of
receipt.

         This engagement is cancelable by either party with 30 days written
notice.

         Upon the signing of the Letter of Engagement, Banchik & Associates asks
for the first month's fee and a letter indicating the expected date by which the
grant will be delivered.

BANCHIK & ASSOCIATES' QUALIFICATIONS

         Banchik & Associates provides comprehensive investor relations
consultation to emerging public companies. Doris Banchik, the firm's principal,
has extensive experience in investment banking, public company management and
investor relations, all of which is brought to bear in a customized approach to
a limited number of exclusive clients.

         Ms. Banchik's investment banking experience includes senior equity
analyst positions at Hainbrecht & Quist (San Francisco), LH Friend, Weinress &
Frankson (Los Angeles) and Dabney, Resnick & Wagner (Beverly Hills). During her
tenure in investment banking, Ms. Banchik analyzed hundreds of companies and
served portfolio managers and buyside analysts at most of the major
institutional houses in the United States. Ms. Banchik's investment banking
experience is balanced by real world management experience in two publicly held
companies. She served as director of finance and planning for the $50 million
psychiatric services subsidiary of American Medical International (formerly
NYSE:AMI) and as vice president of clinical services at Abbey Healthcare Group
(formerly NASDAQ:ABBY).

         Ms. Banchik has been an investor relations consultant to emerging
public companies since 1995. She counts among her clients National Tech Team
(NASDAQ: TEAM); THQ, Inc. (NASDAQ; THQI); Research Engineers, Inc. (NASDAQ:
RENG); Response Oncology, Inc. (NASDAQ: ROIX); Unique Mobility (AMX:UQM); Image
Entertainment (NASDAQ: DISK); Cellegy Pharmaceuticals (NASDAQ: CLGY); Factual

<PAGE>

Data Corp. (NASDAQ: FDCC) and Sound Source Interactive (NASDAQ: SSII) Her
practice is characterized and distinguished by her exclusive management of her
clients' requirements. Ms. Banchik's practice is limited to five clients at any
point in time.

         Ms. Banchik holds a BSN with Honors from Northeastern University, an
MSN from Yale University and an MBA from the Harvard Business School.



REFERENCES
Banchik & Associates has worked with many individuals over the years. Here is an
abbreviated list of contacts representing current and former clients and
individuals with whom we have regular contact.

RESPONSE ONCOLOGY, INC.
Memphis, TN.
(901) 761-7000
JOE CLARK, PRESIDENT & CEO
MARY CLEMENTS, CHIEF FINANCIAL OFFICER

RESEARCH ENGINEERS, INC.
Yorba Linda, CA
(714) 974-2500
DR. JYOTI CHATTERJEE, EXECUTIVE VICE PRESIDENT AND COO [FIRST NAME PRONOUNCED
JOTI] WAYNE BLAIR, CHIEF FINANCIAL OFFICER

UNIQUE MOBILITY, INC.
Golden, CO
(303) 278-2002
DONALD FRENCH, CHIEF FINANCIAL OFFICER
JOHN GOULD, DIRECTOR OF INVESTOR RELATIONS
RAY GEDDES, CHAIRMAN AND CHIEF EXECUTIVE OFFICER

AERO ELECTRIC CONNECTOR, INC.
Torrance, CA
(310) 618-3737
BRIAN PAUL, CHIEF FINANCIAL OFFICER

THQ, INC.
Calabasas, CA.
(818) 591-1310
BRIAN FARRELL, CHIEF EXECUTIVE OFFICER
DEBRA LAKE

NATIONAL TECHTEAM, INC.
Dearbom, MI
(313) 277-2277
LARRY MILLS, CHIEF FINANCIAL OFFICER

<PAGE>

FACTUAL DATA CORP.
Loveland, CO
(800) 929-3400 x 214
ROBB COPP, DIRECTOR OF MARKETING

WEDBUSH MORGAN SECURITIES
Los Angeles, CA
(800) 628-4524
TIMARY KOLLER, VP/BROKER/MONEY MANAGER

VAN KASPER & CO
Newport Beach, CA
(800) 718-4519
W. GORDON MCBEAN, VP INSTITUTIONAL SALES/BROKER

CRUTTENDEN ROTH
Newport Beach, CA
(714) 440-3320
SHELLY SINGHAL, INVESTMENT BANKER




It is certainly my pleasure to forward this proposal to you and look forward to
your response.



Very truly yours,



Doris Banchik
Principal


SIMULATIONS PLUS
Integrating Science and Software



LETTER OF INTENT FOR COOPERATIVE ALLIANCE

This is a non-binding Letter of Intent between Simulations Plus, Inc., 1220 W.
Avenue J, Lancaster, CA ("Simulations Plus") and Absorption Systems LP, Oaklands
Corporate Center, 440 Creamery Way, Suite C, Exton, PA 19341 ("Absorption
Systems"). This letter summarizes our discussions to date and reflects our
mutual interest in fanning a joint venture to pursue the activities described
below.

Simulations Plus has expertise in the development of scientific software
including simulation and data correlation software for the pharmaceutical
industry.

Absorption Systems has expertise in laboratory testing of candidate drug
materials and other chemical compounds related to the absorption of such
materials in tissue culture and under various physiological conditions.

Simulations Plus and Absorption Systems believe that the combined capabilities
of the two companies may provide a unique capability to the pharmaceutical
industry in the area of absorption and general bioavailability.

Simulations Plus and Absorption Systems desire to form a Joint Venture which
combines the capabilities of both companies in such a way as to offer a new
service to the pharmaceutical industry for the study and prediction of the
absorption and general bioavailability of candidate new drug materials. The
structure of the Joint Venture and other related matters will be set forth in a
detailed and definitive agreement, which will contain terms and conditions yet
to be discussed and agreed upon. Among other things, the definitive agreement
will reflect the following:

CONSORTIUM: The Joint Venture will create a consortium of pharmaceutical and
other companies that will each provide large numbers of chemical entities for
comprehensive laboratory screening, data correlation and simulation analysis.
Each consortium member will contract with the Joint Venture, and in turn, the
Joint Venture will contract the respective activities to both Absorption Systems
and Simulations Plus.

SERVICE: The Joint Venture envisions providing a service to pharmaceutical and
biotech companies, whereby Absorption Systems will conduct laboratory
experiments on potential drug compounds provided by the customer to create a
small proprietary database for that customer's compounds. Using the data so
generated, Simulations Plus will then: (1) correlate the data generated by the
Absorption Systems experiments into a proprietary database and computer software
to allow prediction of permeabilities and other molecular parameters for
additional compounds, and (2) generate predictions for such additional compounds

<PAGE>

as the customer may desire, to be provided to the customer in the form of a
report. Customers will benefit from the data generated for other customers, but
no customer will have access to the raw data from any other customer.

EXCLUSIVITY: Both Simulations Plus and Absorption Systems ("The Parties")
possess proprietary assays, processes, know-how, software, mathematical models,
and information ("intellectual property"). Pursuant to the definitive agreement,
each party will license exclusively, certain of their respective intellectual
property, know-how, software, expertise, etc. to the Joint Venture for the sole
purpose of developing the Consortium Database and Consortium Software. This
provision does not preclude Simulations Plus or Absorption Systems from
performing or developing their respective intellectual property, know-how,
software, expertise, or performing contract services independent of the
consortium provided such activities are funded separately and are independent
and do not infringe on the exclusivity of the consortium or consortium
membership.

OWNERSHIP OF THE INTELLECTUAL PROPERTY: In accordance with the terms set forth
in the definitive agreement, the Joint Venture will be the sole owner of all
biological data, mathematical models, and improvements to biological and
chemical assays and software that it purchases from either Absorption Systems or
Simulations Plus during its normal course of business. The Joint Venture will
own all biological data, mathematical models, and improvements to biological and
chemical assays and software it develops or purchases independent of Absorption
Systems or Simulations Plus.

Both Simulations Plus and Absorption Systems agree that this Letter of Intent is
nonbinding; however, by signing this Letter of Intent, each company expresses
its sincere interest in developing the Joint Venture described above.

Both Simulations Plus and Absorption Systems agree that time is of the essence
in forming the joint venture contemplated by this Letter of Intent. To this end,
this Letter of Intent shall expire 60 days from the date of execution, unless
extended in writing by both parties or superceded by a more definitive
agreement.


DATED THIS 9th DAY OF February, 1999
           ---        --------

Simulations Plus, Inc.                      Absorption Systems LP

/s/ Walter S. Woltosz                       /s/ Patrick M. Dentinger
- ---------------------------                 ---------------------------
Chairman and CEO                            President & CEO


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