INSURED MUNICIPALS INCOME TRUST & IN QU TAX EX TR MUL SE 321, 497J, 1999-08-20

INSURED MUNICIPALS INCOME TRUST & IN QU TAX EX TR MUL SE 321
497J, 1999-08-20

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                                 August 20, 1999



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549-1004
Attn:  Filing Desk, Stop 1-4


                 Re:  Van Kampen Focus Portfolios, Municipal Series 321
                      (File No. 333-83353)  (CIK No. 1024840)



Gentlemen:

         In accordance with the provisions of Rule 497(j) of Regulation C under
the Securities Act of 1933 (the "Securities Act") this letter serves to certify
that the most recent amendment to the registration statement of Form S-6 for the
above captioned Trust does not differ from that which would have been filed
pursuant to Rule 497(b) of the Securities Act. Amendment No. 1 to the
registration statement, which was the most recent amendment to the registration
statement, was filed electronically with the Commission on August 19, 1999.


                                                          Very truly yours,


                              VAN KAMPEN FUNDS INC.