VAN KAMPEN AMERICAN CAPITAL EQUITY OPPORTUNITY TRUST SER 146
S-6, 1999-02-04
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                                                                   File No: 333-
                                                                   CIK # 1025272

                       SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549-1004
                                    FORM S-6

For Registration under the Securities Act of 1933 of Securities of Unit
Investment Trusts Registered on Form N-8B-2.

A.    Exact name of Trust:     VAN KAMPEN FOCUS PORTFOLIOS, SERIES 146

B.    Name of Depositor:       VAN KAMPEN FUNDS INC.

C. Complete address of Depositor's principal executive offices:

                               One Parkview Plaza
                               Oakbrook Terrace Illinois  60181

D. Name and complete address of agents for service:

      CHAPMAN AND CUTLER                 VAN KAMPEN FUNDS INC.
      Attention:  Mark J. Kneedy         Attention:  Don G. Powell, Chairman
      111 West Monroe Street             One Parkview Plaza
      Chicago, Illinois  60603           Oakbrook Terrace, Illinois  60181

E. Title of securities being registered: Units of undivided fractional
beneficial interests.

F. Approximate date of proposed sale to the public:

       AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE OF THE REGISTRATION
                                   STATEMENT
- --------------------------------------------------------------------------------

The registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a)
may determine.


<PAGE>










                  Preliminary Prospectus Dated February 4, 1999

                           VAN KAMPEN FOCUS PORTFOLIOS

                                                                      Series 146
                                                       (A Unit Investment Trust)

         The attached final Prospectus for a prior Series of the Trust is hereby
used as a preliminary Prospectus for the above stated Series. The narrative
information and structure of the attached final Prospectus will be substantially
the same as that of the final Prospectus for this Series. Information with
respect to pricing, the number of Units, dates and summary information regarding
the characteristics of securities to be deposited in this Series is not now
available and will be different since each Series has a unique Portfolio.
Accordingly the information contained herein with regard to the previous Series
should be considered as being included for informational purposes only.

         A registration statement relating to the units of this Series will be
filed with the Securities and Exchange Commission but has not yet become
effective. Information contained herein is subject to completion or amendment.
Such Units may not be sold nor may offer to buy be accepted prior to the time
the registration statement becomes effective. This Prospectus shall not
constitute an offer to sell or the solicitation of an offer to buy nor shall
there be any sale of the Units in any state in which such offer, solicitation or
sale would be unlawful prior to registration or qualification under the
securities laws of any such state.

(Incorporated herein by reference is the final prospectus from Van Kampen
American Capital Equity Opportunity Trust, Series 88 (Registration No.
333-43927) as filed on February 6, 1998, which shall be used as a preliminary
prospectus for the current Series of the Trust.)


<PAGE>



                                       S-2
                       CONTENTS OF REGISTRATION STATEMENT

This Registration Statement comprises the following papers and documents:

            The facing sheet
            The Prospectus
            The signatures
            The consents of independent public accountants
              and legal counsel

The following exhibits:

1.1  Proposed form of Trust Agreement (to be supplied by amendment).

3.1  Opinion and consent of counsel as to legality of securities being 
     registered (to be supplied by amendment).

3.2  Opinion and consent of counsel as to New York tax status of securities 
     being registered (to be supplied by amendment).

4.1  Consent of Interactive Data Corporation (to be supplied by amendment).

4.2  Consent of Grant Thornton LLP (to be supplied by amendment).



<PAGE>


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant, Van Kampen Focus Portfolios, Series 146 has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized in the City of Chicago and State of Illinois on the 4th day of
February, 1999.

                                        VAN KAMPEN FOCUS PORTFOLIOS, SERIES 146
                                           (Registrant)

                                        By VAN KAMPEN FUNDS INC.
                                           (Depositor)


                                                    Gina M. Costello     
                                                  Assistant Secretary

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below on February 4, 1999 by the
following persons who constitute a majority of the Board of Directors of Van
Kampen Funds Inc.

          SIGNATURE                             TITLE

Don G. Powell                       Chairman and Chief Executive           )
                                       Officer                             )


John H. Zimmerman                   President and Chief Operating          )
                                       Officer

William R. Rybak                    Executive Vice President and           )
                                       Chief Financial Officer             )

                                                                Gina M. Costello
                                                             (Attorney-in-fact*)

- --------------------------------------------------------------------------------
         *An executed copy of each of the related powers of attorney was filed
with the Securities and Exchange Commission in connection with the Registration
Statement on Form S-6 of Van Kampen American Capital Equity Opportunity Trust,
Series 64 (File No. 333-33087) and Van Kampen American Capital Equity
Opportunity Trust, Series 87 (File No. 333-44581) and the same are hereby
incorporated herein by this reference.




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