PREMIER RESEARCH WORLDWIDE LTD
S-8, 1999-06-07
TESTING LABORATORIES
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<PAGE>
      As filed with the Securities and Exchange Commission on June 7, 1999.
                                                        Registration No. 333-
                                                                         -------
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                               ------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      under
                           THE SECURITIES ACT OF 1933
                               ------------------

                        PREMIER RESEARCH WORLDWIDE, LTD.
               (Exact name of issuer as specified in its charter)

        Delaware                                        22-3264604
(State of incorporation)                    (I.R.S. Employer Identification No.)

                  30 South 17th Street, Philadelphia, PA 19103
                    (Address of Principal Executive Offices)

                          ----------------------------
                        PREMIER RESEARCH WORLDWIDE, LTD.
                             1996 STOCK OPTION PLAN
                            (Full title of the plan)
                          ----------------------------

                           JOEL MORGANROTH, M.D., CEO
                        PREMIER RESEARCH WORLDWIDE, LTD.
                              30 South 17th Street
                             Philadelphia, PA 19103
                                 (215) 972-0420
            (Name, address and telephone number of agent for service)

                                   Copies to:
                             James H. Carll, Esquire
                                Archer & Greiner
                              One Centennial Square
                              Haddonfield, NJ 08033
                                 (609) 795-2121
                          -----------------------------

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------------
                                                                Proposed               Proposed
Title of                                                        maximum                maximum
Securities                                                      offering               aggregate            Amount of
to be                               Amount to be                price per              offering             Registration
Registered                          Registered(1)               share(2)               price                Fee
- ---------------------------------------------------------------------------------------------------------------------------
<S>                                 <C>                         <C>                     <C>                 <C>
Common Shares
Par value $.01 per share            600,000 shares              $6.75                  $4,050,000           $1,113.75
- ---------------------------------------------------------------------------------------------------------------------------
</TABLE>

(1)   Pursuant to Rule 416(a), this Registration Statement includes such
      additional shares of Common Stock as may be issuable by virtue of the
      anti-dilution provisions of the 1996 Stock Option Plan.

(2)   Estimated pursuant to Rule 457 solely for the purpose of calculating the
      registration fee, based upon the average of the high and low sale prices
      reported on the NASDAQ National Market System on June 1, 1999.

      Approximate date of commencement of proposed sale to public: As soon as
practicable after the Registration Statement becomes effective. These securities
are being registered pursuant to Rule 415.


<PAGE>


         This Registration Statement on Form S-8 is being filed to register,
pursuant to the Securities Act of 1933, as amended, 600,000 additional shares of
the Common Stock of Premier Research Worldwide, Ltd., a Delaware corporation
(the "Company"), issuable pursuant to the Premier Research Worldwide, Ltd. 1996
Stock Option Plan. The contents of Registration Statement on Form S-8, File No.
333-26471, previously filed by the Company with the Securities and Exchange
Commission, are incorporated by reference in this Registration Statement and
made a part hereof.

                                       R-3

<PAGE>

                                     PART II


               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 8.  Exhibits.

         The following Exhibits are filed with this Registration Statement or,
as indicated, incorporated by reference:

         Exhibit No.         Description
         -----------         -----------
             4.1             Premier Research Worldwide, Ltd. 1996 Stock
                             Option Plan (incorporated by reference to Exhibit
                             10.7 to the Registration Statement on Form S-1,
                             File No. 333-17001).

             4.2             Amendment No. 1 to 1996 Stock Option Plan

             5               Opinion of Archer & Greiner, P.C. as to legality of
                             securities to be registered

             23.1            Consent of Archer & Greiner, P.C., included in
                             their opinion as Exhibit 5

             23.2            Consent of Arthur Andersen LLP

             24              Power of Attorney (contained on signature page)


                           [INTENTIONALLY LEFT BLANK]


                                       R-4

<PAGE>


                                   SIGNATURES


         Pursuant to the requirements of the Securities Act of 1933, the
undersigned registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Philadelphia, and the Commonwealth of
Pennsylvania on this twenty-fifth day of May, 1999.


                                       PREMIER RESEARCH INTERNATIONAL, LTD.


                                       By: /s/ Joel Morganroth
                                           -------------------------------------
                                               Joel Morganroth, M.D.,
                                               Chief Executive Officer

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.

         Each person whose signature to this Registration Statement appears
below hereby appoints Joel Morganroth, M.D., Fred Powell and James H. Carll, and
each of them, any one of whom may act without the joinder of the others, as his
attorney-in-fact to sign on his behalf individually and in the capacity stated
below and to file all amendments and post-effective amendments to this
Registration Statement, and any and all instruments or documents filed as a part
of or in connection with this Registration Statement or the amendments thereto,
and such attorney-in-fact may make such changes and additions to this
Registration Statement as he may deem necessary or appropriate.


Signature                          Capacity                          Date

/s/ Joel Morganroth        Chief Executive Officer and            May 25, 1999
- ---------------------      Director
Joel Morganroth, M.D.      (Principal executive officer)


/s/ Fred Powell            Vice President - Chief Financial       May 25, 1999
- ---------------------      Officer
Fred Powell                (Principal financial and
                           accounting officer)



/s/  John Aglialoro        Chairman of the Board                  May 25, 1999
- ---------------------      and Director
John Aglialoro

                                       R-5

<PAGE>




/s/ Joan Carter                     Director                      May 25, 1999
- ----------------------------
Joan Carter

/s/ Arthur Hull Hayes, Jr.,         Director                      May 25, 1999
- ----------------------------
Arthur Hull Hayes, Jr., M.D.

/s/ Arthur W. Hicks, Jr.            Director                      May 25, 1999
- ----------------------------
Arthur W. Hicks, Jr.

/s/ Charles L. Jacobson             Director                      May 25, 1999
- ----------------------------
Charles L. Jacobson, M.D.

/s/ Jerry Lee                       Director                      May 25, 1999
- ----------------------------
Jerry Lee

/s/ Philip J. Whitcome              Director                      May 25, 1999
- ----------------------------
Philip J. Whitcome, Ph.D.

____________________________        Director                      May 25, 1999
Connie Woodburn

                                       R-6


<PAGE>



                                  EXHIBIT INDEX



Exhibit No.               Description                                   Page No.
- -----------               -----------                                   --------

   4.2             Amendment No. 1 to 1996
                   Stock Option Plan

   5               Opinion of Archer & Greiner, P.C.
                   as to legality of securities to be registered
                   (with consent included)

  23.2             Consent of Arthur Andersen LLP



<PAGE>

                                   EXHIBIT 4.2


                        PREMIER RESEARCH WORLDWIDE, LTD.

                                 Amendment No. 1
                                       to
                             1996 Stock Option Plan


         The 1996 Stock Option Plan (the "Option Plan") of Premier Research
Worldwide, Ltd. (the "Company") is hereby amended as follows:

         1. Reservation of Additional Shares. Section 4 of the Option Plan is
hereby amended to reserve an additional 600,000 shares of Common Stock for
issuance thereunder.

         2. Fixed Option Grants. The Option Plan is hereby further amended to
include the following new Section 8:

                 8.    Fixed Option Grants to Outside Directors.

                       A.   Defined Terms   (i) The term "Outside Directors" as
                            utilized herein refers to any individual who serves
                            as a member of the Board of Directors of the Company
                            and who is neither (i) an employee of the Company,
                            (ii) the beneficial owner of 10% or more of the
                            outstanding Common Stock of the Company (a
                            "Significant Holder"), or (iii) a stockholder,
                            member or partner of any entity which itself is a
                            Significant Holder.

                            (ii) The term "Annual Meeting" as utilized herein
                                 refers to an Annual Meeting of Stockholders of
                                 the Company.

                       B.   Initial Grants   Each Outside Director initially
                            elected to the Board of Directors at or after the
                            1999 Annual Meeting shall be automatically granted,
                            on the date of such election, an option to acquire
                            5,000 shares of the Common Stock of the Company.

                       C.   Annual Grants   Each Outside Director who is a
                            member of the Company's Board of Directors
                            immediately following an Annual Meeting (including
                            the 1999 Annual Meeting) shall be automatically
                            granted, on the date of the Annual Meeting, an
                            option to acquire 5,000 shares of the Common Stock
                            of the Company, provided that an Outside Director
                            first elected to the Board of Directors at such
                            Annual Meeting or within six months prior to such
                            Annual Meeting shall not be eligible for the annual
                            grant otherwise to be issued at the date of such
                            Annual Meeting.

<PAGE>




                       D.   Terms of Fixed Option Grants.   Options granted
                            pursuant to this Section 8 will be subject to all of
                            the terms and conditions of the Option Plan. In
                            addition, each such option shall be subject to the
                            following terms:

                            (i)   The option price per share shall be 100% of
                                  the fair market value of the Common Stock on
                                  the close of business on the date the option
                                  is granted, determined as provided in the
                                  Option Plan.

                            (ii)  Each option will be immediately exercisable
                                  upon grant.

                            (iii) Shares of Common Stock received upon exercise
                                  of the options granted pursuant to this
                                  Section 8 may not be sold, transferred,
                                  assigned, pledged or otherwise disposed of
                                  until at least six months and one day after
                                  the date of grant.

                            (iv)  Each option will expire upon the earlier of
                                  (a) ten years from the date of grant or (b)
                                  three months after the Outside Director ceases
                                  to serve as a director for any reason.

         3. Effective Date.   This Amendment No. 1 shall be not be effective
until its approval by the stockholders of the Company at the 1999 Annual
Meeting.




<PAGE>

                                    EXHIBIT 5


                                ARCHER & GREINER
                           A Professional Corporation

                                COUNSELORS AT LAW
                              ONE CENTENNIAL SQUARE
                                 P. O. BOX 3000
                       HADDONFIELD, NEW JERSEY 08033-0968


                                                                   June 7, 1999

Premier Research Worldwide, Ltd.
30 S. 17th Street
Philadelphia, PA 19103

Dear Sirs:

         We have examined the corporate records and proceedings of Premier
Research Worldwide, Ltd., a Delaware corporation, with respect to the legal
sufficiency of all corporate proceedings of such corporation taken in connection
with the creation, form and validity and full payment and non-assessability when
issued of the 600,000 shares of common stock, par value $0.01 per share, covered
by the Registration Statement on Form S-8, dated June 7, 1999, in connection
with which Registration Statement this opinion is rendered.

         Based upon such examination, we are of the opinion that when the
Registration Statement shall have been declared effective by order of the
Securities and Exchange Commission, and the shares shall have been issued and
sold upon the terms and conditions set forth in the Registration Statement, such
shares will be validly authorized and legally issued, fully paid, and
non-assessable.

         We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement.

                                                   Sincerely,




                                                   ARCHER & GREINER
                                                   A Professional Corporation




<PAGE>
                                  EXHIBIT 23.2



                    Consent of Independent Public Accountants


As independent public accountants, we hereby consent to the incorporation by
reference in this registration statement of our report dated February 3, 1999
included in the Company's Form 10-K for the year ended December 31, 1998 and to
all references to our Firm included in this registration statement.



                                             Arthur Andersen LLP




Philadelphia, PA,
June 7, 1999



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