PREMIER RESEARCH WORLDWIDE LTD
10-Q, 1999-11-15
TESTING LABORATORIES
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<PAGE>

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 205498

                                    FORM 10-Q

(Mark One)

[X] Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange
    Act of 1934.

For the quarterly period ended September 30, 1999
                               ------------------

                                       or

[ ] Transitional report pursuant to Section 13 or 15(d) of the Securities
    Exchange Act of 1934

For the transitional period from                       to
                                 ----------------------  ----------------------

Commission file number  0-29100
                      ---------

                        PREMIER RESEARCH WORLDWIDE, LTD.
             -----------------------------------------------------
             (Exact name of registrant as specified in its charter)

<TABLE>
<CAPTION>
<S>                                                                  <C>
                          Delaware                                                            22-3264604
- -------------------------------------------------------------        --------------------------------------------------------------
       (State or other jurisdiction of incorporation                                (I.R.S. Employer Identification No.)
                      or organization)

                  30 South 17th Street
                    Philadelphia, PA                                                               19103
- -------------------------------------------------------------        --------------------------------------------------------------
       (Address of principal executive offices)                                                  (Zip Code)

</TABLE>

                                  215-972-0420
              ----------------------------------------------------
              (Registrant's telephone number, including area code)


                                       N/A
- --------------------------------------------------------------------------------
              (Former name, former address and formal fiscal year,
                          if changed since last report)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports, and (2) has been subject to such filing
requirements for the past 90 days. X  Yes    No
                                  ---    ---

Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

The number of shares of Common Stock, $.01 par value, outstanding as of November
12, 1999, was 6,862,250.

<PAGE>


                PREMIER RESEARCH WORLDWIDE, LTD. AND SUBSIDIARIES

                                      INDEX
                                      -----
<TABLE>
<CAPTION>

                                                                                                                       Page
                                                                                                                       ----
<S>                                                                                                                  <C>
Part I.  Financial Information

             Item 1.       Financial Statements

                           Condensed consolidated balance sheets--September 30, 1999 (unaudited) and
                           December 31, 1998                                                                              3
                           Condensed consolidated statements of operations (unaudited)--Three Months
                           And Nine Months Ended September 30, 1999 and 1998                                              4

                           Condensed consolidated statements of cash flows (unaudited)--Nine Months
                           Ended September 30, 1999 and 1998                                                              5

                           Notes to condensed consolidated financial statements (unaudited)                             6-8

             Item 2.       Management's Discussion and Analysis of Financial Condition and Results of
                           Operations                                                                                  8-13

             Item 3.       Qualitative and Quantitative Disclosures about Market Risks.                                  13


Part II. Other Information 13
             Item 2.       Changes in Securities and Use of Proceeds                                                     14

             Item 6.       Exhibits and Reports on Form 8-K                                                              15

                           a.)      Exhibits


                           b.)      Reports on Form 8-K


Signatures                                                                                                               16
</TABLE>
                                       2




<PAGE>


                PREMIER RESEARCH WORLDWIDE, LTD. AND SUBSIDIARIES
                      CONDENSED CONSOLIDATED BALANCE SHEETS
                      (in thousands, except share amounts)
<TABLE>
<CAPTION>


                                                                                 September 30, 1999        December 31, 1998
                                                                                 ------------------        -----------------
                                                                                    (unaudited)
<S>                                                                                <C>                      <C>
ASSETS

Current assets:
   Cash and cash equivalents                                                             $ 12,893                   $ 10,822
   Short-term investments                                                                   4,604                      5,668
   Accounts receivable, net                                                                10,963                     10,423
   Prepaid expenses and other                                                               1,486                      2,176
   Deferred income taxes                                                                      159                        159
                                                                                         --------                   --------
         Total current assets                                                              30,105                     29,248

Property and equipment, net                                                                 4,408                      4,110
Goodwill, net                                                                               1,923                      2,160
Other assets                                                                                1,023                      1,023
Deferred income taxes                                                                       2,644                      3,631
                                                                                         --------                   --------
                                                                                         $ 40,103                   $ 40,172
                                                                                         ========                   ========


LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
   Accounts payable                                                                         1,520                   $  2,519
   Accrued expenses                                                                         3,273                      1,156
   Deferred revenues                                                                        4,583                      5,556
                                                                                         --------                   --------
         Total current liabilities                                                          9,376                      9,231
                                                                                         --------                   --------
Commitments and contingencies

Stockholders' equity:
    Preferred stock-$10 par value, 500,000 shares authorized,
               none issued and outstanding                                                      --                         --
    Common stock-$.01 par value, 15,000,000 shares authorized,
               7,322,530 and 7,217,520 shares issued                                            73                         72
    Additional paid-in capital                                                              37,298                     37,061
    Treasury stock, 499,800 and 177,800 shares at cost                                      (2,711)                      (779)
    Accumulated deficit                                                                     (3,933)                    (5,413)
                                                                                          --------                   --------
         Total stockholders' equity                                                         30,727                     30,941
                                                                                          --------                   --------
                                                                                          $ 40,103                   $ 40,172
                                                                                          ========                   ========
</TABLE>


         The accompanying notes are an integral part of these statements


                                       3

<PAGE>

                PREMIER RESEARCH WORLDWIDE, LTD. AND SUBSIDIARIES
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                    (in thousands, except per share amounts)
<TABLE>
<CAPTION>

                                                         Three Months Ended                          Nine Months Ended
                                                            September 30,                              September 30,
                                                   ----------------------------             ----------------------------------
                                                        1999            1998                       1999               1998
                                                        ----            ----                       ----               ----
                                                            (unaudited)                                 (unaudited)

<S>                                                <C>               <C>                     <C>                  <C>
Revenues                                             $ 13,804        $  9,855                   $ 39,984             $ 27,443
Less-Reimbursed costs                                  (2,363)         (1,696)                    (8,026)              (4,440)
                                                     --------        --------                   --------             --------

Net revenues                                           11,441           8,159                     31,958               23,003
                                                     --------        --------                   --------             --------
Costs and expenses:
     Direct costs                                       4,343           3,360                     13,891                9,677
     Selling, general and administrative                5,638           4,251                     14,325               12,182
     Depreciation and amortization                        585             416                      1,658                1,146
                                                     --------        --------                   --------             --------
Total costs and expenses                               10,566           8,027                     29,874               23,005
                                                     --------        --------                   --------             --------
Income (loss) from operations                             875             132                      2,084                   (2)

Other income, net                                          97             216                        383                  727
                                                     --------        --------                   --------             --------
Income before income taxes                                972             348                      2,467                  725
Income tax provision                                      389             138                        987                  290
                                                     --------        --------                   --------             --------
Net income                                           $    583        $    210                   $  1,480             $    435
                                                     ========        ========                   ========             ========

Basic and diluted net income per share               $   0.08        $   0.03                   $   0.21             $   0.06
                                                     ========        ========                   ========             ========
</TABLE>





         The accompanying notes are an integral part of these statements

                                       4



<PAGE>



                PREMIER RESEARCH WORLDWIDE, LTD. AND SUBSIDIARIES
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                 (in thousands)
<TABLE>
<CAPTION>
                                                                                             Nine Months Ended September 30,
                                                                                           ---------------------------------
                                                                                               1999                   1998
                                                                                               ----                   ----
                                                                                                       (unaudited)
<S>                                                                                        <C>                    <C>
Operating activities:
  Net income                                                                               $  1,480               $    435
  Adjustments to reconcile net income to net cash
          provided by (used in) operating activities:
                Depreciation and amortization                                                 1,658                  1,146
                Provision for doubtful accounts                                                 206                     --
                Deferred income taxes                                                           987                    290
                Changes in assets and liabilities:
                    Accounts receivable                                                        (746)                (3,105)
                    Prepaid expenses and other                                                  690                   (510)
                    Accounts payable                                                           (999)                  (673)
                    Accrued expenses                                                          2,117                    302
                    Deferred revenues                                                          (973)                 1,558
                                                                                           --------               --------
                         Net cash provided by (used in) operating activities                  4,420                   (557)
                                                                                           --------               --------

Investing activities:
     Purchases of property and equipment                                                     (1,719)                (1,756)
     America's Doctor investment                                                                 --                 (1,000)
     Proceeds from sales of short-term investments                                            1,064                  9,462
                                                                                           --------               --------
                         Net cash provided by (used in) investing activities                   (655)                 6,706
                                                                                           --------               --------

Financing activities:
     Repurchase of common stock for treasury                                                 (1,932)                  (540)
     Net proceeds from exercise of stock options                                                238                    552
                                                                                           --------               --------
                         Net cash provided by (used in) financing activities                 (1,694)                    12
                                                                                           --------               --------
Net increase in cash and cash equivalents                                                     2,071                  6,161
Cash and cash equivalents, beginning of period                                               10,822                  4,679
                                                                                           --------               --------

Cash and cash equivalents, end of period                                                   $ 12,893               $ 10,840
                                                                                           ========               ========
</TABLE>



         The accompanying notes are an integral part of these statements

                                       5


<PAGE>



                PREMIER RESEARCH WORLDWIDE, LTD. AND SUBSIDIARIES
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                   (Unaudited)

Note 1. Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been
prepared in accordance with generally accepted accounting principles for interim
financial information and with the instructions to Form 10-Q and Article 10 of
Regulation S-X. Accordingly, they do not include all the information and
footnotes required by generally accepted accounting principles for complete
financial statements. In the opinion of management, all adjustments (consisting
of normal recurring adjustments) considered necessary for fair presentation have
been included. Operating results for the periods ended September 30, 1999, are
not necessarily indicative of the results that may be expected for the year
ending December 31, 1999. Further information on potential factors that could
affect the Company's financial results can be found in the Company's S-1
Registration Statement and its Reports on Forms 10-K and 10-Q filed with the
Securities and Exchange Commission.

Note 2. Net Income per Share

The Company follows SFAS No. 128 "Earnings per Share". This statement requires
the presentation of basic and diluted earnings per share. Basic net income per
share is computed by dividing net income by the weighted average number of
shares of common stock outstanding during the year. Diluted net income per share
is computed by dividing net income by the weighted average number of shares of
common stock outstanding during the year, adjusted for the dilutive effect of
common stock equivalents, which consist primarily of stock options, using the
treasury stock method.

The table below sets forth the reconciliation of the numerators and denominators
of the basic and diluted net income per share computations.

Three Months Ended September 30,
- --------------------------------
<TABLE>
<CAPTION>

                                                                                                        Per
                                                                      Net                              Share
1999                                                                Income          Shares             Amount
- ----                                                                ------          ------             ------

<S>                                                               <C>             <C>                  <C>
Basic........................................................     $ 583,000       7,011,000            $  0.08
Effect of dilutive shares...................................             --          74,000                 --
                                                                  ---------       ---------            -------
Diluted......................................................     $ 583,000       7,085,000            $  0.08
                                                                  =========       =========            =======

1998
- ----
Basic........................................................     $ 210,000       7,106,000            $  0.03
Effect of dilutive shares...................................             --          79,000                 --
                                                                  ---------       ---------            -------
Diluted......................................................     $ 210,000       7,185,000            $  0.03
                                                                  =========       =========            =======
</TABLE>

Options to purchase 213,029 and 652,132 shares of common stock were outstanding
at September 30, 1999 and 1998, respectively but were not included in the
computation of diluted net income per share for the three months ended September
30, 1999 and 1998 because the option exercise prices were greater than the
average market price of the Company's common stock during the period.


                                       6


<PAGE>



Nine Months Ended September 30,
- -------------------------------
<TABLE>
<CAPTION>

                                                                                                        Per
                                                                      Net                              Share
1999                                                                Income          Shares             Amount
- ----                                                                ------          ------             ------

<S>                                                               <C>             <C>                  <C>
Basic........................................................   $ 1,480,000       7,057,000            $  0.21
Effect of dilutive shares...................................             --          94,000                 --
                                                                -----------       ---------            -------
Diluted......................................................   $ 1,480,000       7,151,000            $  0.21
                                                                ===========       =========            =======

1998
- ----

Basic........................................................   $   435,000       7,121,000            $  0.06
Effect of dilutive shares...................................             --          96,000                 --
                                                                -----------       ---------            -------
Diluted......................................................   $   435,000       7,217,000            $  0.06
                                                                ===========       =========            =======
</TABLE>

Options to purchase 239,275 and 634,951 shares of common stock were outstanding
at September 30, 1999 and 1998, respectively but were not included in the
computation of diluted net income per share for the nine months ended September
30, 1999 and 1998 because the option exercise prices were greater than the
average market price of the Company's common stock during the period.

Note 3. Comprehensive Income

The Company follows SFAS No. 130, "Reporting Comprehensive Income." The
Company's comprehensive income includes net income and unrealized gains and
losses from foreign currency translation and short-term investments. These
unrealized gains and losses were immaterial as of September 30, 1999 and 1998.

Note 4 Operating Segments

In June 1997, SFAS No. 131, "Disclosure about Segments of an Enterprise and
Related Information," was issued, effective for fiscal years ending after
December 15, 1998. The Company adopted this statement for the year ended
December 31, 1998. The Company's reportable segments are strategic business
units that offer different products and services to a common client base.

The Company's products and services are provided through two business segments,
both in the United States and internationally: Clinical Operations, which
includes centralized diagnostic testing services, clinical trial management
services and clinical data management services; and Technology Operations, which
includes clinical trial and data management software, support and consulting
services. The Company's discontinued Phase I Clinical Research Unit and Clinical
Laboratory operations and income and expense not allocated to reportable
segments are reported as Other.

The Company evaluates performance based on the net revenues and operating
earnings performance of the respective business segments.


                                       7

<PAGE>



Segment information is as follows:
<TABLE>
<CAPTION>


                                                                      Three months ended September 30,1999
                                                       -------------------------------------------------------------------
                                                         Clinical
                                                       Operations         Technology               Other           Total
                                                       ----------         ----------               -----           -----
<S>                                                    <C>                <C>                 <C>              <C>
Net revenues from external customers                   $  6,915,000       $  4,439,000        $    87,000      $11,441,000
Income (loss) from operations                              (772,000)         1,799,000           (152,000)         875,000
Identifiable assets                                      14,763,000          3,912,000         21,428,000       40,103,000

                                                                     Three months ended September 30, 1998
                                                       -------------------------------------------------------------------
                                                         Clinical
                                                       Operations         Technology               Other           Total
                                                       ----------         ----------               -----           -----
Net revenues from external customers                     $5,146,000         $2,611,000           $402,000       $8,159,000
Income (loss) from operations                              (497,000)           684,000            (55,000)         132,000
Identifiable assets                                      10,695,000          3,494,000         24,128,000       38,317,000

                                                                       Nine months ended September 30,1999
                                                       -------------------------------------------------------------------
                                                         Clinical
                                                       Operations         Technology               Other           Total
                                                       ----------         ----------               -----           -----
Net revenues from external customers                    $23,055,000         $8,324,000           $579,000      $31,958,000
Income (loss) from operations                               300,000          2,240,000           (456,000)       2,084,000
Identifiable assets                                      14,763,000          3,912,000         21,428,000       40,103,000

                                                                      Nine months ended September 30, 1998
                                                       -------------------------------------------------------------------
                                                         Clinical
                                                       Operations         Technology           Other               Total
                                                       ----------         ----------           -----               -----
Net revenues from external customers                    $13,955,000         $7,592,000         $1,456,000      $23,003,000
Income (loss) from operations                            (1,639,000)         1,368,000            269,000           (2,000)
Identifiable assets                                      10,695,000          3,494,000         24,128,000       38,317,000

</TABLE>

Item 2. Management's Discussion and Analysis of Financial Condition and Results
        of Operations

Overview

The Company is a clinical research organization providing a broad range of
integrated product development services on a global basis to its clients in the
pharmaceutical, biotechnology and medical device industries. The Company's
products and services are provided, both in the United States and
internationally, through two business segments: Clinical Operations, which
includes centralized diagnostic testing services, clinical trial management
services and clinical data management services; and Technology Operations, which
includes the development, marketing and support of clinical trial and data
management software, support and consulting services. The Company had operated a
Phase I Clinical Research Unit, which was closed in the first quarter of 1998.

         The Company's centralized diagnostic testing services are on a
fee-for-service basis and contracts generally have terms of one month to two
years. A portion of the Company's fee frequently is paid upon contract execution
as a non-refundable up-front payment, with the remaining amounts billed monthly.
Clinical trial and data management services are generally fixed priced
contracts, with certain variable components, and range in duration from a few
months to two years. A portion of the Company's fee frequently is paid upon
contract execution as a non-refundable up-front payment, with the balance billed
in accordance with the contract terms. The Company's contracts generally may be
terminated with or without cause on 30 to 90 days notice. Clients terminate or
delay contracts for a variety of reasons, including, among others, the failure
of the product(s) being tested to satisfy safety or efficacy requirements;
unexpected or undesired clinical results of the product; the client's decision
to forego a particular study; insufficient patient enrollment or investigator
recruitment; and production problems resulting in shortages of required
supplies. Revenues from clinical trial software and services are derived
primarily from software license fees, software maintenance and support and
consulting services.

                                       8
<PAGE>


         Revenues from centralized diagnostic testing services are recognized as
the services are performed. Revenues from clinical trial and data management
services are generally recognized on a percentage of completion basis as work is
performed. The Company regularly subcontracts with third-party investigators in
connection with clinical trials and with other third-party providers for
specialized services. These and other reimbursable costs are paid by the Company
and reimbursed by clients and, in accordance with industry practice, are
included in revenues. Since reimbursed costs may vary significantly from
contract to contract and are not meaningful for analyzing trends in revenues,
they are included in gross revenues but excluded from net revenues.

              Revenues from technology software licenses are recognized upon
shipment of the software and related documentation when collectibility is deemed
probable and the license fee is deemed fixed and determinable. Revenues from
software maintenance and continuing support contracts are recognized on a
straight-line basis over the period in which the software maintenance and
continuing support is provided, generally twelve months. Revenues from
consulting and training services are recognized when the services are performed.

Results of Operations

Three months ended September 30, 1999 compared to three months ended September
30, 1998

Net revenues for the three months ended September 30, 1999, increased $3,282,000
or 40.2% to $11,441,000 compared to $8,159,000 for the three months ended
September 30, 1998.

The Company's net revenues from its Clinical Operations increased $ 1,768,000 or
34.3% to $6,915,000 for the period ended September 30, 1999 compared to
$5,146,000 for the same period in 1998. The increase in net revenues was the
result of the Company's strong performance in centralized diagnostic testing
services, which increased $1,558,000 or 78.0% to $3,555,000 in the 1999 period
from $1,996,000 in the 1998 period. In addition, the Company's clinical trial
and data management services net revenues increased $210,000 or 6.7% to
$3,360,000 for the three months ended September 30, 1999 from $3,150,000 for the
three months ended September 30, 1998. Overall, the increase in net revenues for
Clinical Operations resulted from revenues recognized from the Company's
contract backlog and new clinical contracts signed during 1999.

The Company has decided to phase out its clinical laboratory operations, which
primarily provided blood sample testing in conjunction with clinical trials.
Contractual client obligations for these services will be met through
subcontracting agreements with comparable laboratories, beginning in the third
quarter of 1999. During the three months ended September 30, 1999, net revenues
from clinical laboratory operations were $87,000 compared to $347,000 for the
three months ended September 30, 1998.

Net revenues for Technology Operations increased $1,828,000 or 70.0% to
$4,439,000 for the three months ended September 30, 1999 from $2,611,000 for the
three months ended September 30, 1998. During the third quarter of 1999, the
Company signed a five-year agreement to provide software and consulting services
to link up to four hundred investigational sites in a worldwide oncology trial.
The increase in net revenues was due primarily to the recognition of the first
portion of the revenue from this contract. Included in the net revenues of
Technology Operations for the three months ended June 30, 1999 was $575,000 in
consulting revenues relating to the Company's consulting contract with
AmericasDoctor.com, Inc.

During the third quarter of 1998, the Company recorded net revenues of $55,000
from its Phase I unit, which was closed during the first quarter of 1998.

Direct costs for the three months ended September 30, 1999 increased $983,000 or
29.3% to $4,343,000 from $3,360,000 for the three months ended September 30,
1999. The increase in direct costs is due to increased staffing and
subcontracting costs to support client contract requirements and to accommodate
projected future net revenues. Direct costs, as a percentage of net revenues,
for the three months ended September 30, 1999 were 38.0% compared with 41.2% in
1998. The decrease in direct costs as a percentage of revenues was due primarily
to the Company's ability to leverage the fixed portion of its direct costs
against an increased revenue base.

                                       9
<PAGE>



Selling, general and administrative expenses increased $1,387,000 or 32.6% to
$5,638,000 for the three months ended September 30, 1999 from $4,251,000 for the
three months ended September 30, 1998. The increase in selling, general and
administrative expenses is due to increased personnel and personnel related
costs, performance-based incentive compensation programs established in 1999 and
direct selling expenses related to Technology license revenues recognized in the
quarter. As a percentage of net revenues, selling, general and administrative
expenses were 49.3% for the third quarter of 1999 compared to 52.1% for the
third quarter of 1998. The decline in the percentage was due primarily to the
Company's ability to leverage the fixed portion of its selling, general and
administrative expenses against an increased revenue base.

Depreciation and amortization expense increased to $585,000 in the third quarter
of 1999 from $416,000 in the comparable 1998 quarter. The increase was due to
increased depreciation expense resulting from additional capital spending to
support the growth in net revenues.

Other income, which consists primarily of interest earned on the Company's cash,
cash equivalents and short-term investments, decreased to $97,000 from $216,000
for the three months ended September 30, 1999 and 1998, respectively. The
decrease is due to lower cash and short-term investment balances in 1999 as a
result of the Company's use of cash to support working capital, capital
expenditure needs and the share repurchase program in 1999.

The Company's effective tax rate was 40.0% for the three months ended September
30, 1999 and 1998.

Nine months ended September 30, 1999 compared to nine months ended September 30,
1998

Net revenues for the nine months ended September 30, 1999, increased $8,955,000
or 38.9% to $31,958,000 compared to $23,003,000 for the nine months ended
September 30, 1998.

The Company continued to experience a strong increase in net revenues in its
Clinical Operations, which increased $9,100,000 or 65.2% to $23,055,000 for the
period ended September 30, 1999 compared to $13,955,000 for the same period in
1998. The increase in net revenues was the result of the Company's strong
performance in centralized diagnostic testing services, which increased
$4,406,000 or 78.1% to $10,045,000 in the 1999 period from $5,639,000 in the
1998 period. In addition, the Company's clinical trial and data management
services net revenues increased $4,694,000 or 56.4% to $13,010,000 for the nine
months ended September 30, 1999 from $8,316,000 for the nine months ended
September 30, 1998. Overall, the increase in net revenues for Clinical
Operations resulted from revenues recognized from the Company's contract backlog
and new clinical contracts signed during the nine months ended September 30,
1999.

The Company has decided to phase out its clinical laboratory operations, which
primarily provides blood sample testing in conjunction with clinical trials.
Contractual client obligations for these services will be met through
subcontracting agreements with comparable laboratories, beginning in the third
quarter of 1999. During the nine months ended September 30, 1999, net revenues
from clinical laboratory operations were $579,000 compared to $1,267,000 for the
nine months ended September 30, 1998.

Net revenues for Technology Operations increased $732,000 or 9.6% to $8,324,000
for the nine months ended September 30, 1999 from $7,592,000 for the nine months
ended September 30, 1998. During the third quarter of 1999, the Company signed a
significant, five-year agreement to provide software and consulting services to
link up to four hundred investigational sites in a worldwide oncology trial. The
increase in net revenues was due primarily to the recognition of the first
portion of the revenue from this contract. Included in the net revenues for
Technology Operations for the nine months ended September 30, 1999 was
$1,725,000 in consulting revenues relating to the Company's consulting contract
with AmericasDoctor.com, Inc.

During the nine months ended September 30, 1998, the Company recorded net
revenues of $189,000 from its Phase I unit, which was closed during the first
quarter of 1998.

Direct costs for the nine months ended September 30, 1999 increased $4,214,000
or 43.5% to $13,891,000 from $9,677,000 for the nine months ended September 30,
1999. The increase in direct costs is due to increased staffing and
subcontracting costs to support client contract requirements and to accommodate
projected future net revenues. Direct costs, as a percentage of net revenues,
for the nine months ended September 30, 1999 were 43.5% compared to 42.1% for
the same period in 1998. The increase in direct costs as a percentage of net
revenues is due to the increase in staff and subcontracting costs and to the
mix of revenues as Clinical Operations net revenues have a higher direct cost
ratio than Technology Operations net revenues.

                                       10
<PAGE>



Selling, general and administrative expenses increased $2,143,000 or 17.6% to
$14,325,000 for the nine months ended September 30, 1999 from $12,182,000 for
the nine months ended September 30, 1998. The increase in selling, general and
administrative expenses is due to increased personnel related, performance-based
incentive compensation programs established in 1999, direct selling expenses
related to Technology license revenues recognized in the third quarter and other
expenses incurred in the nine months ended September 30, 1999 including $250,000
of closedown costs for the clinical laboratory. As a percentage of net revenues,
selling, general and administrative expenses were 44.8% for the nine months
ended September 30, 1999 compared to 53.0% for the nine months ended September
30, 1998. The decline in the percentage was due primarily to the Company's
ability to leverage the fixed portion of its selling, general and administrative
expenses against an increased revenue base.

Depreciation and amortization expense increased to $1,658,000 for the nine
months ended September 30, 1999 from $1,146,000 in the comparable 1998 period.
The increase was due to increased depreciation expense resulting from additional
capital spending to support the growth in net revenues.

Other income, which consists primarily of interest earned on the Company's cash,
cash equivalents and short-term investments, decreased to $383,000 from $727,000
for the nine months ended September 30, 1999 and 1998, respectively. The
decrease is due to lower cash and short-term investment balances in 1999 as a
result of the Company's use of cash to support working capital and capital
expenditure needs and the share repurchase program in 1999.

The Company's effective tax rate was 40.0% for the six months ended June 30,
1999 and 1998.


Liquidity and Capital Resources

For the nine months ended September 30, 1999, the Company generated cash from
operations of $4,420,000 compared to cash used in operations of $557,000 for the
nine months ended September 30, 1998. The year-to-year change was primarily the
result of increased income before depreciation and amortization, increased
accrued expenses and improved receivable collection partially offset by reduced
accounts payable and deferred revenues.

At September 30, 1999, the Company had $12,893,000 of cash and cash equivalents
and $4,604,000 invested in short-term marketable securities. For the nine months
ended September 30, 1999, the Company sold, upon maturity, $1,064,000 of
short-term investments and re-invested the proceeds in investments with
maturities of ninety days or less. The Company generally places its investments
in A1P1 rated commercial bonds and paper, municipal securities and certificates
of deposit with maturities of less than one year.

During the nine months ended September 30, 1999, the Company purchased
$1,719,000 of equipment compared to $1,756,000 during the nine months ended
September 30, 1998. The equipment purchases in 1999 reflect the additional
capital equipment needed to support the growth of the Company.

During the nine months ended September 30, 1999, the Company received $238,000
in cash from the exercise of 105,010 employee stock options.

The Company has renewed through June 30, 2000, its bank line of credit that
provides for borrowings up to $3,000,000 at an interest rate of prime minus 35
basis points. The line of credit agreement includes certain covenants, the most
restrictive of which limit future indebtedness and require compliance with a
liabilities-to-tangible net worth ratio. To date, the Company has not borrowed
any amounts under its line of credit.

During the nine months ended September 30, 1999, the Company used $1,932,000 to
repurchase 322,000 shares of the Company's common stock at a price of $6 per
share. The Company's share repurchase program is now complete, having
repurchased 499,800 shares of the 500,000 authorized by the Board of Directors
on July 20, 1998. In total, the Company used $2,711,000 to repurchase 499,800
shares at an average price of $5.42 per share.

The Company expects that existing cash and cash equivalents, short-term
investments, cash flows from operations and borrowings under its line of credit
will be sufficient to meet its foreseeable cash needs for at least the next
year. However, there may be acquisition and other growth opportunities that
require additional external financing and the Company may from time to time seek
to obtain additional funds from the public or private issuances of equity or
debt securities. There can be no assurance that such financings will be
available or available on terms acceptable to the Company.

                                       11
<PAGE>



Year 2000

The Company is aware of the issues and problems associated with the Year 2000
date change. The Company has been addressing company-wide data processing and
infrastructure issues since 1995. Premier Research had undertaken a Year 2000
Compliance Plan that was completed by September 30, 1999. In addition, the
Company had all clinical systems Year 2000 compliant by July 31, 1999. The
purpose of this plan is to assure that Premier Research, as a corporate entity,
has assessed and taken appropriate actions necessary to become compliant with
any issues regarding Year 2000 requirements. The problems surrounding Year 2000
compliance are of extreme concern to the Company, since Premier Research is a
clinical research organization providing diagnostic testing and clinical
research services to the pharmaceutical industry, as well as a developer of
clinical database management software. The Company produces and delivers
information that is date sensitive, especially in deriving date and time
calculations; Premier Research currently can provide to its clients, date
formats that contain century markers or 4-digit year fields for any of its
clinical and diagnostic information.

The Company's strategy to address Year 2000 compliance is to replace potentially
non-compliant software and hardware with new compliant systems or updated Year
2000 compliant versions. The inventory and assessment phases of the Year 2000
plan have primarily been completed for its hardware and software systems. The
Company has begun its remediation phase of the plan through the replacement and
updating of systems.

As of today all of the Company's information technology infrastructure has been
assessed and have been found free from any Year 2000 issues. Those that have
shown not to be in compliance are currently being evaluated and renovated for
compliance. If a system can not be made compliant to the requirements, the
system will be replaced with one that is compliant.

The Company is also assessing its facilities worldwide that it leases or owns,
and plans to complete its deployment of applicable contingency plans by December
1, 1999.

The Company is also assessing and surveying its suppliers of third party
products and services. Based upon information received from such parties, the
Company believes that most of its suppliers are developing, assessing and
remediating any issues associated with their Year 2000 plans. The Company cannot
at this time fully assess the status of its suppliers until they have completed
their own efforts. It will review the readiness of the suppliers on an on-going
basis throughout the remainder of the year and will implement specific actions
to rectify potential problems in its supply chain.

As with any other company in its industry or any business in general, the
Company is exposed to risks associated with failures in the private and public
sector to become Year 2000 compliant. These risks include the possibility that
public infrastructure systems, such as electricity, water, natural gas or
telecommunications may fail in this country and other countries in the world
that the Company does business. In addition, there are those risks that the
internal systems of the Company's suppliers, service providers and customers
will fail. The Company also relies considerably on travel and could be adversely
affected, if air and train travel is disrupted by issues related to the Year
2000.

The Company also relies heavily on the healthcare industry. This industry and
its related clinical investigational sites may not have focused their efforts on
the Year 2000 issue to the same degree. Thus the Company has an increased risk
that its investigational sites, necessary for the conduct of clinical trials,
will be unable to provide timely answers and data that it needs to perform
services on time to its contractual clients. Also, the failure of the Company's
customers to address the Year 2000 issue could negatively impact on their
ability to use the Company's services. While contingency plans will be developed
to address these risks, the Company cannot assure that those plans will
sufficiently protect the Company from the effects of those risks. Any
disruptions from the realization of any of these risks could adversely affect
the Company's ability to perform its services.

The Company estimates that the costs associated with its Year 2000 program will
be approximately $ 0.5 million, including costs already incurred. Total Year
2000 costs of approximately $0.3 million have been incurred by the Company
through September 30, 1999. The estimates of cost, timing and impact of
addressing the Year 2000 issue are based on numerous assumptions of future
events, including the continued availability of certain resources, the ability
of the Company to meet its deadlines and the cooperation of third parties.
However, there can be no guarantee that the assumptions will be correct and that
these estimates will be achieved. Actual results could differ significantly from
those expected by the Company.

                                       12
<PAGE>



Inflation

The Company believes the effects of inflation generally do not have a material
adverse effect on its results of operations or financial condition.

Cautionary Statement for Forward-Looking Information.

Statements included in Management's Discussion and Analysis of Financial
Condition and Results of Operations set forth above may constitute
forward-looking statements within the meaning of the Private Securities
Litigation Reform Act of 1995. Such statements involve a number of risks and
uncertainties such as competitive factors, technology development, market demand
and the Company's ability to obtain new contracts and accurately estimate net
revenues due to variability in size, scope and duration of projects, and
internal issues of the sponsoring client. Further information on potential
factors that could affect the Company's financial results can be found in the
Company's S-1 Registration Statement and its Reports on Form 10-K and 10-Q filed
with the Securities and Exchange Commission.

Item 3. Qualitative and Quantitative Disclosures About Market Risk

The Company's primary financial market risks include fluctuations in interest
rates and currency exchange rates.

There have been no significant changes since December 31, 1998.




                                       13



<PAGE>



Part II. Other Information

Item 2. Changes in Securities and Use of Proceeds
<TABLE>
<CAPTION>
<S>     <C>                                  <C>                                  <C>



(1)    Effective Date of Securities Act Registration Statement:        February 3, 1997
       registration No.:   333-17001

(2)    Offering Date:      February 4, 1997

(3)      Not Applicable

(4)     (i) The offering terminated after all shares registered were sold

       (ii) Managing Underwriters:  Montgomery Securities
                                    Furman Selz
                                    Genesis Merchant Group

      (iii) Class of Securities Registered: Common Stock

       (iv)                                    Account of Company             Account of Selling Shareholder
                                               ------------------             ------------------------------
            Amount Registered                  2,206,250 common stock         956,250 common stock

            Aggregate price of
            Amount Registered                  $37,506,250                    $16,256,250

            Amount Sold                          2,206,250                        956,250

            Aggregate Offering
            Price of Amount Sold               $37,506,250                     16,256,250

       (v)  Expenses of offering for account of the Company:
            Underwriting Discount and Commission                               $2,625,437
            Other expenses                                                       $698,813
            Total Expenses                                                     $3,324,250

            (A)   There were no direct or indirect payments to directors,
                  officers, general partners of the issuer or their associates;
                  to persons owning ten (10) percent or more of common stock of
                  the Company; or affiliates of the Company.

            (B) All of the above payments were direct or indirect payments to others not
                described in clause (A).


      (vi)  Net Offering Proceeds to the Company:                             $34,182,000

     (vii)  Use of Proceeds as of September 30, 1999:
            Net cash paid for business acquisition:                             8,655,000
            Net cash paid for minority equity investment                        1,000,000
            Common stock re-purchase                                            2,711,000
            Purchase of Equipment:                                              6,579,000
            Working Capital:                                                   (2,260,000)
            Temporary Investments (consisting of short-term,
            Investment-grade securities):                                       4,604,000

            All of the above payments were to others not described in item (v)(A) above.

    (viii) The use of proceeds is consistent with the Prospectus

</TABLE>
                                       14

<PAGE>



Item 6. Exhibits and Reports on Form 8-K

        a.) Exhibits

            10.25 Registration Rights Agreement dated August 27, 1999.
                  Incorporated by reference to Exhibit 10.1, filed in connection
                  with the Company's Form 8-K dated August 27, 1999.

            10.26 Put Option Agreement dated August 27, 1999. Incorporated by
                  reference to Exhibit 10.1, filed in connection with the
                  Company's Form 8-K dated August 27, 1999.

            10.27 Employment Agreement with Joel Morganroth, M.D., filed
                  herewith. *

            10.28 Management Consulting Agreement with Joel Morganroth, M.D.,
                  filed herewith. *

            10.29 Employment Agreement with Joseph Esposito, filed herewith. *

            10.30 Employment Agreement with John R. Bauer, filed herewith. *

            10.31 Amendment No. 1 to Premier Research Worldwide 1996 Stock
                  Option Plan (Incorporated by reference to Exhibit 4.2 to the
                  Registration Statement on Form S-8, File No. 333-80121). *

            27.0  Financial Data Schedule

            * Management contract or compensatory plan or arrangement.


        b.) Reports on Form 8-K

            On September 9, 1999 the Registrant filed a Report on Form 8-K dated
            August 27, 1999, reporting on a change in control.


                                       15


<PAGE>



                                   Signatures


              Pursuant to the requirements of the Securities and Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned thereunto duly authorized.



                                           PREMIER RESEARCH WORLDWIDE, LTD.
                                                     (Registrant)

Date:  November 15, 1999                   By: /s/ Joel Morganroth
                                              ---------------------------------
                                                   Joel Morganroth, MD
                                                   Chairman and Chief
                                                   Executive Officer



Date:  November 15, 1999                   By: /s/ John R. Bauer
                                              ----------------------------------
                                                   John R. Bauer
                                                   Chief Financial Officer
                                                   (Principal Financial an
                                                   Accounting Officer)

                                       16


<PAGE>

                         MANAGEMENT EMPLOYMENT AGREEMENT


The following agreement is hereby entered into between, Joel Morganroth, M.D.
(hereinafter known as Employee) and Premier Research Worldwide (together with
its affiliated corporations hereinafter known as the "Company") and having its
principal offices at 30 S. 17th Street, Philadelphia, PA 19103.

1.         DUTIES AND RESPONSIBILITIES

           Employee agrees to hold the position of Chief Executive Officer and
           Chairman of the Board shall be directly responsible to the Board of
           Directors.

2.         BEST EFFORTS

           Employee agrees to devote best his efforts to his employment with
           the Company.

3.         ETHICAL CONDUCT

           Employee will conduct himself in a professional and ethical manner at
           all times and will comply with all company policies as well as all
           State and Federal regulations and laws as they may apply to the
           services, products, and business of the Company.

4.         TERM OF THE AGREEMENT

           This agreement will be for a period of one year, commencing September
           7, 1999 and will continue from year to year unless terminated.

5.         Compensation

           a)         Salary shall be $204,000/year payable in equal
                      installments as per the company's payroll policy.

           b)         Benefits shall be the standard benefits of the Company as
                      they shall exist from time to time with the exception of
                      vacation which is four weeks/year.

6.         NON-DISCLOSURE

           Employee acknowledges that employment with the Company requires him
           to have access to confidential information and material belonging to
           the Company, including customer lists, contracts, proposals,
           operating procedures, and trade secrets. Upon termination of
           employment for any reason, Employee agrees to return to the Company
           any such confidential information and material in his possession with
           no copies thereof retained. Employee further agrees, whether during
           employment with the Company or any time after the termination thereof
           (regardless of the reason for such termination), he will not

                                       1
<PAGE>


           disclose nor use in any manner, any confidential or proprietary
           material relating to the business, operations, or prospects of the
           Company except as authorized in writing by the Company.

7.         BUSINESS INTERFERENCE

           During employment with the Company and for a period of one year
           thereafter (regardless of the reason for termination) employee agrees
           he will not, directly or indirectly, in any way for his own account,
           as employee, stockholder, partner, or otherwise, or for the account
           of any other person, corporation, or entity inappropriately or
           unethically solicit clients, Premier Research Worldwide employees or
           independent contractors that would interfere with the business of the
           Company.

8.         INVENTIONS

           Employee agrees to promptly disclose to the Company each discovery,
           improvement, or invention conceived, made, or reduced to practice
           (whether during working hours or otherwise) during the term of
           employment. Employee agrees to grant to the Company the entire
           interest in all of such discoveries, improvements, and inventions and
           to sign all patent/copyright applications or other documents needed
           to implement the provisions of this paragraph without additional
           consideration. Employee further agrees that all works of authorship
           subject to statutory copyright protection developed jointly or
           solely, while employed shall be considered a work made for hire and
           any copyright thereon shall belong to the Company. Any invention,
           discovery, or improvement conceived, made, or disclosed, during the
           one year period following the termination of employment with the
           Company shall be deemed to have been made, conceived, or discovered
           during employment with the Company.

           Employee acknowledges that the only discoveries, improvements, and
           other inventions made prior to the date hereof which have not been
           filed in the United States Patent Office are attached as Exhibit A.

9.         NO CURRENT CONFLICT

           Employee hereby assures the Company that he is not currently
           restricted by any existing employment or non-compete agreement that
           would conflict with the terms of this Agreement.

10.        TERMINATION AND TERMINATION BENEFITS

           Employment is "at will" which means that either the Company or
           Employee may terminate at any time, with or without cause or good
           reason.

           a)         The Company may terminate other than for "cause" at any
                      time upon 30 days written notice to Employee. In such
                      case, the Company will pay severance to Employee equal to
                      one year's annual salary and applicable prorated bonus,
                      payable in one lump sum in accordance with the Company's
                      policy.

                      In addition, the Executive will continue to receive
                      (subject to payment of any applicable premium co-pay)
                      standard health, dental, disability, life and accident


                                       2
<PAGE>

                      insurance benefits for the one year period following the
                      termination of employment.

           b)         Notwithstanding any contrary provision contained in this
                      Employment Agreement, in the event that either (a) there
                      is a "Change of Control" (as hereafter defined) and
                      neither the Company nor the Buyer offers the Executive a
                      position with comparable responsibilities, authority,
                      location or compensation, or (b) after the date of the
                      Change in Control but before the first anniversary
                      thereof, the Executive's responsibilities, authority,
                      location, or compensation are not acceptable to the
                      Executive the Executive may elect to resign and receive
                      severance equal to one year's annual salary and applicable
                      prorated bonus, hereunder, payable in one lump sum in
                      accordance with the Company's policy.

                      In addition, the Executive will continue to receive
                      (subject to payment of any applicable premium co-pay)
                      standard health, dental, disability, life and accident
                      insurance benefits for the one year period following the
                      termination of employment.

                      The Executive must provide written notice of such election
                      not less than sixty days following the date of the Change
                      of Control or, if the Executive's new position is changed
                      within the time period and in the manner described above,
                      within thirty days following such event.

                      The term "Change of Control", as utilized herein, refers
                      to:

                           (i)      A change of control of a nature that would
                                    be required to be reported in the Company's
                                    proxy statement under the Securities
                                    Exchange Act of 1934, as amended;

                           (ii)     The approval by the Board of Directors of a
                                    sale, not in the ordinary course of
                                    business, of all or substantially all of the
                                    Company's assets and business to an
                                    unrelated third party and the consummation
                                    of such transaction; or

                           (iii)    The approval by the Board of Directors of
                                    any merger, consolidation, or like business
                                    combination or reorganization of the
                                    Company, the consummation of which would
                                    result in the occurrence of any event
                                    described in clause (i) or (ii) above, and
                                    the consummation of such transaction.

                      Except as expressly modified and amended hereby, the
                      Employment Agreement and its terms and provisions are
                      hereby ratified, confirmed and approved in all respects.

           c)         The Company may terminate employment for cause at any time
                      upon 30 days written notice setting forth the nature of
                      such cause. The following, as determined by the Company in
                      its reasonable judgment, shall constitute "cause" for
                      termination:

                                       3
<PAGE>

                      (1)        Employee's gross failure to perform duties and
                                 responsibilities as outlined in the job
                                 description dated October 1996 or as amended
                                 thereafter.
                      (2)        Any employee gross misconduct which is directly
                                 and severely injurious to the business of the
                                 Company.
                      (3)        Violation of any federal, state, or local law
                                 applicable to the business of the Company.
                      (4)        Any material breach of this agreement.

           d)         Employee may terminate employment at any time, with or
                      without good reason, upon 90 days written notice to the
                      Company.

           e)         If Employee resigns or employment is terminated by the
                      Company for cause, the Company shall have no further
                      obligation to Employee other than for annual salary,
                      benefits, and applicable prorated bonus earned through the
                      date of termination.

           f)         References herein to a "prorated bonus" refer to the
                      annual bonus in which the Executive then participates,
                      prorated for the portion of the year in which his
                      employment continues hereunder and based upon Company
                      performance during such portion of the year.

11.        MISCELLANEOUS

           a)         This Agreement and any disputes arising herefrom shall be
                      governed by Pennsylavnia law.

           b)         In the event that any provision of this Agreement is held
                      to be invalid or unenforceable for any reason, including
                      without limitation the geographic or business scope or
                      duration thereof, this Agreement shall be construed as if
                      such provision had been more narrowly drawn so as not to
                      be invalid or unenforceable.

           c)         This Agreement supersedes all prior agreements,
                      arrangements, and understandings, written or oral,
                      relating to the subject matter.

           d)         The failure of either party at any time or times to
                      require performance of any provision hereof shall in no
                      way affect the right at a later time to enforce the same.


For Employee:                                For the Company:


___________________________________          ___________________________________

Date: _____________________________          Date: _____________________________



                                       4


<PAGE>

                         MANAGEMENT CONSULTANT AGREEMENT


The following agreement is hereby entered into between, Joel Morganroth, M.D.,
P.C. (hereinafter known as Consultant) and Premier Research Worldwide (together
with its affiliated corporations hereinafter known as the "Company") and having
its principal offices at 30 S. 17th Street, Philadelphia, PA 19103

1.         SCOPE OF PROJECT

           a)         Consultant agrees to serve as Medical Director and/or
                      principal investigator and to advise the Company on
                      matters related to the successful operation of the
                      Company's Clinical Research Business unit.

           b)         Consultant agrees to provide medical interpretation for
                      diagnostic tests as such reading is from time to time
                      required.

2.         ETHICAL CONDUCT

           Consultant will conduct himself in a professional and ethical manner
           at all times and will comply with all Company policies as well as all
           State and Federal regulations and laws as they may apply to the
           services, products, and business of the Company.

3.         Compensation

           a)         Fees shall be $156,000/year payable in twelve equal
                      installments by the 15th of each month

           b)         Consultant will be reimbursed for reasonable out of picket
                      disbursement properly documented.

           c)         Consultant agrees to maintain his medical licenses as
                      required to carry out the duties described herein.

           d)         Consultant shall be acting as an independent contractor
                      and not as an employee of the Company. Payment of any tax
                      and/or social security liabilities relative to this
                      compensation shall be the responsibility of the
                      Consultant.

                                       1
<PAGE>


4.         NON-DISCLOSURE

           Consultant acknowledges that consultancy for the Company requires him
           to have access to confidential information and material belonging to
           the Company, including customer lists, contracts, proposals,
           operating procedures, and trade secrets. Upon termination of the
           consulting relationship for any reason, Consultant agrees to return
           to the Company any such confidential information and material in his
           possession with no copies thereof retained. Consultant further
           agrees, whether during the term of this agreement with the Company or
           any time after the termination thereof (regardless of the reason for
           such termination), he will not disclose nor use in any manner, any
           confidential or other material relating to the business, operations,
           or prospects of the Company except as authorized in writing by the
           Company.


5.         INVENTIONS

           a)         Consultant agrees to promptly disclose to the Company each
                      discovery, improvement, or invention conceived, made, or
                      reduced to practice during the term of employment.
                      Consultant further agrees to grant to the Company the
                      entire interest in all of such discoveries, improvements,
                      and inventions and to sign all patent/copyright
                      applications or other documents needed to implement the
                      provisions of this paragraph without additional
                      consideration. Consultant further agrees that all works of
                      authorship subject to statutory copyright protection
                      developed jointly or solely, while employed shall be
                      considered property of the Company and any copyright
                      thereon shall belong to the Company. Any invention,
                      discovery, or improvement conceived, made, or disclosed,
                      during the one year period following the termination of
                      this agreement shall be deemed to have been made,
                      conceived, or discovered during the term hereof.

           b)         If publication of data generated from studies conducted
                      under the auspices of the Company is anticipated,
                      Consultant agrees to obtain permission from the Company
                      for such publication


6.         NO CURRENT CONFLICT

           Employee hereby assures the Company that he/she is not currently
           restricted by any existing employment or non-compete agreement that
           would conflict with the terms of this Agreement.


7.         TERM OF AGREEMENT

           The term of this Agreement is one year commencing from July 29, 1999
           and will continue from year to year unless terminated.


                                       2
<PAGE>


8.         TERMINATION

           a)         The Company may terminate consulting services at any time
                      upon without the need to show cause upon 180 days written
                      notice to Consultant.

           b)         The Company may terminate consulting services without
                      notice for failure to meet obligations under the
                      Agreement. The following, as determined by the Company in
                      its reasonable judgement, shall constitute failure to meet
                      these obligations:

                      (1)        Consultant's failure to perform services
                                 defined under the scope of the project.

                      (2)        Any misconduct which is injurious to the
                                 business or interests of the Company.

                      (3)        Violation of any federal, state, or local law
                                 applicable to the business of the Company.

                      (4)        Any material breach of this agreement.

           c)         Consultant may terminate employment at any time upon 60
                      days written notice to the Company.

9.         MISCELLANEOUS

           a)         This Agreement and any disputes arising herefrom shall be
                      governed by Pennsylavnia law.

           b)         In the event that any provision of this Agreement is held
                      to be invalid or unenforceable for any reason, including
                      without limitation the geographic or business scope or
                      duration thereof, this Agreement shall be construed as if
                      such provision had been more narrowly drawn so as not to
                      be invalid or unenforceable.

           c)         This Agreement supersedes all prior agreements,
                      arrangements, and understandings, written or oral,
                      relating to the subject matter.

           d)         The failure of either party at any time or times to
                      require performance of any provision hereof shall in no
                      way affect the right at a later time to enforce the same.

For Consultant:                              For the Company:


___________________________________          ___________________________________

Date: _____________________________          Date: _____________________________


                                       3



<PAGE>

                         MANAGEMENT EMPLOYMENT AGREEMENT
                         -------------------------------

The following agreement is hereby entered into between, Joseph Esposito
(hereinafter known as Employee) and Premier Research Worldwide (together with
its affiliated corporations hereinafter known as the "Company") and having its
principal offices at 30 S. 17th Street, Philadelphia, PA 19103

1.  DUTIES AND RESPONSIBILITIES
    ---------------------------

    Employee agrees to hold the position of President and Chief Operating
    Officer of Premier Research Worldwide, Ltd. and shall be directly
    responsible to the Chief Executive Officer.

2.  BEST EFFORTS
    ------------

    Employee agrees to devote his best efforts to his employment with the
    Company.

3.  ETHICAL CONDUCT
    ---------------

    Employee will conduct himself in a professional and ethical manner at
    all times and will comply with all company policies as well as all
    State and Federal regulations and laws as they may apply to the
    services, products, and business of the Company.

4.  TERM OF THE AGREEMENT
    ---------------------

    This agreement will be for a period of one year, commencing September
    7, 1999 and will continue from year to year unless terminated.

5.  COMPENSATION
    ------------

    a) Salary shall be $270,000/year payable in equal installments as per the
       company's payroll policy.

    b) Benefits shall be the standard benefits of the Company as they shall
       exist from time to time with the exception of vacation which is four
       weeks/year.

6.  NON-DISCLOSURE
    --------------

    Employee acknowledges that employment with the Company requires him
    to have access to confidential information and material belonging to
    the Company, including customer lists, contracts, proposals,
    operating procedures, and trade secrets. Upon termination of
    employment for any reason, Employee agrees to return to the Company
    any such confidential information and material in his possession with
    no copies thereof retained. Employee further agrees, whether during
    employment with the Company or any time after the termination thereof
    (regardless of the reason for such termination), he will not disclose
    nor use in any manner, any confidential or proprietary material
    relating to the business, operations, or prospects of the Company
    except as authorized in writing by the Company.


                                       1
<PAGE>


7.  BUSINESS INTERFERENCE
    ---------------------

    During employment with the Company and for a period of one year thereafter
    (regardless of the reason for termination) employee agrees he will not,
    directly or indirectly, in any way for his own account, as employee,
    stockholder, partner, or otherwise, or for the account of any other person,
    corporation, or entity inappropriately or unethically solicit clients,
    Premier Research Worldwide employees or independent contractors that would
    interfere with the business of the Company.


8.  INVENTIONS
    ----------

    Employee agrees to promptly disclose to the Company each discovery,
    improvement, or invention conceived, made, or reduced to practice (whether
    during working hours or otherwise) during the term of employment. Employee
    agrees to grant to the Company the entire interest in all of such
    discoveries, improvements, and inventions and to sign all patent/copyright
    applications or other documents needed to implement the provisions of this
    paragraph without additional consideration. Employee further agrees that all
    works of authorship subject to statutory copyright protection developed
    jointly or solely, while employed shall be considered a work made for hire
    and any copyright thereon shall belong to the Company. Any invention,
    discovery, or improvement conceived, made, or disclosed, during the one year
    period following the termination of employment with the Company shall be
    deemed to have been made, conceived, or discovered during employment with
    the Company.

    Employee acknowledges that the only discoveries, improvements, and other
    inventions made prior to the date hereof which have not been filed in the
    United States Patent Office are attached as Exhibit A.


9.  NO CURRENT CONFLICT
    -------------------

    Employee hereby assures the Company that he is not currently restricted by
    any existing employment or non-compete agreement that would conflict with
    the terms of this Agreement.


10. TERMINATION AND TERMINATION BENEFITS
    ------------------------------------

    Employment is "at will" which means that either the Company or Employee may
    terminate at any time, with or without cause or good reason.


                                       2
<PAGE>

    a) The Company may terminate other than for "cause" at any time upon 30 days
       written notice to Employee. In such case, the Company will pay severance
       to Employee equal to one year's annual salary and applicable prorated
       bonus, payable in one lump sum in accordance with the Company's policy.

       In addition, the Executive will continue to receive (subject to payment
       of any applicable premium co-pay) standard health, dental, disability,
       life and accident insurance benefits for the one year period following
       the termination of employment.

    b) Notwithstanding any contrary provision contained in this Employment
       Agreement, in the event that either (a) there is a "Change of Control"
       (as hereafter defined) and neither the Company nor the Buyer offers the
       Executive a position with comparable responsibilities, authority,
       location or compensation, or (b) after the date of the Change in Control
       but before the first anniversary thereof, the Executive's
       responsibilities, authority, location, or compensation are not acceptable
       to the Executive the Executive may elect to resign and receive severance
       equal to one year's annual salary and applicable prorated bonus,
       hereunder, payable in one lump sum in accordance with the Company's
       policy.

       In addition, the Executive will continue to receive (subject to payment
       of any applicable premium co-pay) standard health, dental, disability,
       life and accident insurance benefits for the one year period following
       the termination of employment.

       The Executive must provide written notice of such election not less than
       sixty days following the date of the Change of Control or, if the
       Executive's new position is changed within the time period and in the
       manner described above, within thirty days following such event.

       The term "Change of Control", as utilized herein, refers to:

         (i) A change of control of a nature that would be required to be
             reported in the Company's proxy statement under the Securities
             Exchange Act of 1934, as amended;

        (ii) The approval by the Board of Directors of a sale, not in the
             ordinary course of business, of all or substantially all of the
             Company's assets and business to an unrelated third party and the
             consummation of such transaction; or

       (iii) The approval by the Board of Directors of any merger,
             consolidation, or like business combination or reorganization of
             the Company, the consummation of which would result in the
             occurrence of any event described in clause (i) or (ii) above, and
             the consummation of such transaction.

                                       3
<PAGE>


             Except as expressly modified and amended hereby, the Employment
             Agreement and its terms and provisions are hereby ratified,
             confirmed and approved in all respects.

    c) The Company may terminate employment for cause at any time upon 30 days
       written notice setting forth the nature of such cause. The following, as
       determined by the Company in its reasonable judgment, shall constitute
       "cause" for termination:

       (1) Employee's failure to perform duties and responsibilities to the
           Company.
       (2) Any employee misconduct which, in the discretion of the Company, is
           injurious to the business or interests of the Company.
       (3) Violation of any federal, state, or local law applicable to the
           business of the Company.
       (4) Any material breach of this agreement.

    d) Employee may terminate employment at any time, with or without good
       reason, upon 30 days written notice to the Company.

    e) If employee resigns or employment is terminated by the Company for cause,
       the Company shall have no further obligation to Employee other than for
       annual salary, benefits, and applicable prorated bonus earned through the
       date of his termination

    f) References herein to a "prorated bonus" refer to the annual bonus in
       which the Executive then participates, prorated for the portion of the
       year in which his employment continues hereunder and based upon Company
       performance during such portion of the year.


11. MISCELLANEOUS
    -------------

    a) This Agreement and any disputes arising herefrom shall be governed by
       Pennsylvania law.

    b) In the event that any provision of this Agreement is held to be invalid
       or unenforceable for any reason, including without limitation the
       geographic or business scope or duration thereof, this Agreement shall be
       construed as if such provision had been more narrowly drawn so as not to
       be invalid or unenforceable.

    c) This Agreement supersedes all prior agreements, arrangements, and
       understandings, written or oral, relating to the subject matter.

                                       4
<PAGE>


    d) The failure of either party at any time or times to require performance
       of any provision hereof shall in no way affect the right at a later time
       to enforce the same.



For Employee:                            For the Company:


- -------------------------------------    ---------------------------------------


Date:                                    Date:
     ---------------------------------        ----------------------------------


                                       5

<PAGE>

                         MANAGEMENT EMPLOYMENT AGREEMENT
                         -------------------------------

The following agreement is hereby entered into between, John Bauer (hereinafter
known as Employee) and Premier Research Worldwide (together with its affiliated
corporations hereinafter known as the "Company") and having its principal
offices at 30 S. 17th Street, Philadelphia, PA 19103

1.         DUTIES AND RESPONSIBILITIES
           ---------------------------

           Employee agrees to hold the position of Chief Financial Officer and
           shall be directly responsible to the Chief Executive Officer.

2.         BEST EFFORTS
           ------------

           Employee agrees to devote best efforts to his employment with the
           Company.

3.         ETHICAL CONDUCT
           ---------------

           Employee will conduct himself in a professional and ethical manner at
           all times and will comply with all company policies as well as all
           State and Federal regulations and laws as they may apply to the
           services, products, and business of the Company.

4.         TERM OF THE AGREEMENT
           ---------------------

           This agreement will be for a period of one year, commencing September
           7, 1999 and will continue from year to year unless terminated.

5.         COMPENSATION
           ------------

           a)    Salary shall be $95,000/year payable in equal installments as
                 per the company's payroll policy.

           b)    Benefits shall be the standard benefits of the Company as they
                 shall exist from time to time.

6.         NON-DISCLOSURE
           --------------

           Employee acknowledges that employment with the Company requires him
           to have access to confidential information and material belonging to
           the Company, including customer lists, contracts, proposals,
           operating procedures, and trade secrets. Upon termination of
           employment for any reason, Employee agrees to return to the Company
           any such confidential information and material in his possession with
           no copies thereof retained. Employee further agrees, whether during
           employment with the Company or any time after the termination thereof
           (regardless of the reason for such termination), he will not disclose
           nor use in any manner, any confidential or proprietary material
           relating to the business, operations, or prospects of the Company
           except as authorized in writing by the Company.



                                        1
<PAGE>

7.         BUSINESS INTERFERENCE
           ---------------------

           During employment with the Company and for a period of one year
           thereafter (regardless of the reason for termination) employee agrees
           he will not, directly or indirectly, in any way for his own account,
           as employee, stockholder, partner, or otherwise, or for the account
           of any other person, corporation, or entity inappropriately or
           unethically solicit clients, Premier Research Worldwide employees or
           independent contractors that would interfere with the business of the
           Company.



8.         INVENTIONS
           ----------

           Employee agrees to promptly disclose to the Company each discovery,
           improvement, or invention conceived, made, or reduced to practice
           (whether during working hours or otherwise) during the term of
           employment. Employee agrees to grant to the Company the entire
           interest in all of such discoveries, improvements, and inventions and
           to sign all patent/copyright applications or other documents needed
           to implement the provisions of this paragraph without additional
           consideration. Employee further agrees that all works of authorship
           subject to statutory copyright protection developed jointly or
           solely, while employed shall be considered a work made for hire and
           any copyright thereon shall belong to the Company. Any invention,
           discovery, or improvement conceived, made, or disclosed, during the
           one year period following the termination of employment with the
           Company shall be deemed to have been made, conceived, or discovered
           during employment with the Company.

           Employee acknowledges that the only discoveries, improvements, and
           other inventions made prior to the date hereof which have not been
           filed in the United States Patent Office are attached as Exhibit A.

9.         NO CURRENT CONFLICT
           -------------------

           Employee hereby assures the Company that he is not currently
           restricted by any existing employment or non-compete agreement that
           would conflict with the terms of this Agreement.

10.        TERMINATION AND TERMINATION BENEFITS
           ------------------------------------

           Employment is "at will" which means that either the Company or
           Employee may terminate at any time, with or without cause or good
           reason.

            a)        The Company may terminate other than for "cause" at any
                      time upon 30 days written notice to Employee. In such
                      case, the Company will pay severance to Employee equal to
                      six month's salary and applicable prorated bonus, payable
                      in one lump sum in accordance with the Company's policy.

                      In addition, the Executive will continue to receive
                      (subject to payment of any applicable premium co-pay)
                      standard health, dental, disability, life and accident
                      insurance benefits for the one year period following the
                      termination of employment.




                                       2
<PAGE>


             b)       Notwithstanding any contrary provision contained in this
                      Employment Agreement, in the event that either (a) there
                      is a "Change of Control" (as hereafter defined) and
                      neither the Company nor the Buyer offers the Executive a
                      position with comparable responsibilities, authority,
                      location or compensation, or (b) after the date of the
                      Change in Control but before the first anniversary
                      thereof, the Executive's responsibilities, authority,
                      location, or compensation are not acceptable to the
                      Executive the Executive may elect to resign and receive
                      severance equal to six month's salary and applicable
                      prorated bonus, hereunder, payable in one lump sum in
                      accordance with the Company's policy.

                      In addition, the Executive will continue to receive
                      (subject to payment of any applicable premium co-pay)
                      standard health, dental, disability, life and accident
                      insurance benefits for the one year period following the
                      termination of employment.

                      The Executive must provide written notice of such election
                      not less than sixty days following the date of the Change
                      of Control or, if the Executive's new position is changed
                      within the time period and in the manner described above,
                      within thirty days following such event.

                      The term "Change of Control", as utilized herein, refers
                      to:

                           (i)      A change of control of a nature that would
                                    be required to be reported in the Company's
                                    proxy statement under the Securities
                                    Exchange Act of 1934, as amended;

                           (ii)     The approval by the Board of Directors of a
                                    sale, not in the ordinary course of
                                    business, of all or substantially all of the
                                    Company's assets and business to an
                                    unrelated third party and the consummation
                                    of such transaction; or

                           (iii)    The approval by the Board of Directors of
                                    any merger, consolidation, or like business
                                    combination or reorganization of the
                                    Company, the consummation of which would
                                    result in the occurrence of any event
                                    described in clause (i) or (ii) above, and
                                    the consummation of such transaction.

                      Except as expressly modified and amended hereby, the
                      Employment Agreement and its terms and provisions are
                      hereby ratified, confirmed and approved in all respects.

           c)         The Company may terminate employment for cause at any time
                      upon 30 days written notice to the Employee setting forth
                      the nature of such cause. The following, as determined by
                      the Company in its reasonable judgment, shall constitute
                      "cause" for termination:

                      (1)    Employee's failure to perform duties and
                             responsibilities to the Company.
                      (2)    Any employee misconduct which, in the discretion of
                             the Company, is injurious to the
                             business or interests of the Company.



                                        3
<PAGE>

                      (3)    Violation of any federal, state, or local law
                             applicable to the business of the Company.
                      (4)    Any material breach of this agreement.

           d)         Employee may terminate employment at any time, with or
                      without good reason, upon 30 days written notice to the
                      Company.

           e)         If employee resigns or employment is terminated by the
                      Company for cause, the Company shall have no further
                      obligation to Employee other than for six month's salary,
                      benefits, and applicable prorated bonus earned through the
                      date of termination.

           f)         References herein to a "prorated bonus" refer to the
                      annual bonus in which the Executive then participates,
                      prorated for the portion of the year in which his
                      employment continues hereunder and based upon the Company
                      performance during such portion of the year.


11.        MISCELLANEOUS
           -------------

           a) This Agreement and any disputes arising herefrom shall be governed
              by Pennsylvania law.

           b) In the event that any provision of this Agreement is held to be
              invalid or unenforceable for any reason, including without
              limitation the geographic or business scope or duration thereof,
              this Agreement shall be construed as if such provision had been
              more narrowly drawn so as not to be invalid or unenforceable.

           c) This Agreement supersedes all prior agreements, arrangements, and
              understandings, written or oral, relating to the subject matter.

           d) The failure of either party at any time or times to require
              performance of any provision hereof shall in no way affect the
              right at a later time to enforce the same.


For Employee:                                        For the Company:



__________________________________                   ___________________________



Date:_____________________________                   Date:______________________


<TABLE> <S> <C>


<ARTICLE>                     5
<CIK>                         0001026650
<NAME>                        PREMIER RESEARCH WORLDWIDE
<MULTIPLIER>                  1000
<CURRENCY>                    US

<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   SEP-30-1999
<EXCHANGE-RATE>                                       1.00
<CASH>                                              12,893
<SECURITIES>                                         4,604
<RECEIVABLES>                                       11,412
<ALLOWANCES>                                         (449)
<INVENTORY>                                              0
<CURRENT-ASSETS>                                    30,105
<PP&E>                                              13,427
<DEPRECIATION>                                       9,019
<TOTAL-ASSETS>                                      40,103
<CURRENT-LIABILITIES>                                9,376
<BONDS>                                                  0
                                    0
                                              0
<COMMON>                                                73
<OTHER-SE>                                          30,654
<TOTAL-LIABILITY-AND-EQUITY>                        30,727
<SALES>                                                  0
<TOTAL-REVENUES>                                    31,958
<CGS>                                                    0
<TOTAL-COSTS>                                       13,891
<OTHER-EXPENSES>                                    15,983
<LOSS-PROVISION>                                         0
<INTEREST-EXPENSE>                                       0
<INCOME-PRETAX>                                      2,467
<INCOME-TAX>                                           987
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<EXTRAORDINARY>                                          0
<CHANGES>                                                0
<NET-INCOME>                                         1,480
<EPS-BASIC>                                         0.21
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</TABLE>


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