GRANAHAN INVESTMENT MANAGEMENT INC/MA
13F-HR, 2000-10-05
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FORM 13F
INFORMATION REQUIRED OF INSTITUTIONAL INVESTMENT
MANAGERS PURSUANT TO SECTION 13 (f) OF THE SECURITIES
EXCHANGE ACT OF 1934 AND RULES THEREUNDER

Securities and Exchange Commission
Washington, D.C.  20524

Report of the Calendar Quarter Ending September 30, 2000

If amended report check here:____

Name of Institutional Investment Manager:

Granahan Investment Management, Inc.	S.E.C. File Number 28-5876

Business Address:

275 Wyman Street	Suite 270	Waltham	        MA	02451
Street			Suite #		City		State	Zip

Name, Phone no. and Title of Person Duly Authorized to Submit this Report:

Jane M. White, Executive Vice President	(781)890-4412

ATTENTION - Intentional misstatements or omissions of facts constitute
Federal Criminal Violations.  Sec 18 U.S.C. 1991 and 15 U.S.C. 78 ff(a).

The institutional investment manager submitting this Form and its
attachments and the person by whom it is signed represent hereby that all
information contained therein is true, correct and complete.  It is
understood that all required items, statements and schedules are considered
integral parts of this Form and that the submission of any amendment
represents that all unamended items, statements and schedules remain true,
correct and complete as previously submitted.

Pursuant to the requirements of Securities Exchange Act of 1934, the
undersigned institutional investment manager has caused this report to be
signed on its behalf in the City of Waltham and State of Massachusetts on
the 5th day of October, 2000.

                              Granahan Investment Management, Inc.
                             (Name of Institutional Investment Mgr.)



                                     ________________________________
                                     By:  Jane M. White
					  Executive Vice President




Item 6
For all Securities:  Sole Investment Discretion

Item 7
Name and 13F file numbers of ALL Institutional Investment Manager with
respect to which this schedule is filed (other than the one filing this
report) (List in alphabetical order).

			NONE


<TABLE>
Granahan Investment Management
September 30, 2000

Item 1                   Item 2   Item 3     Item 4 Item 5  Item Item 7
                         Title of            Mkt Val
Name of Issuer           Class    Cusip      (x$1000) Quantity  Sole None
<S>                      <C>      <C>        <C>      <C>       <C>  <C>
ABGENIX, INC             Common   00339B107  19,969    247,100    0   247,100
AC NIELSON               Common   004833109  20,788    873,000    0   873,000
ACCRUE SOFTWARE          Common   00437w102   2,567    215,000    0   215,000
ACT MANUFACTURING        Common   000973107  17,877    338,900    0   338,900
ACUSON                   Common   005113105  13,878    610,000    0   610,000
ACXIOM                   Common   005125109  18,815    592,600    0   592,600
ADAPTIVE BROADBAND       Common   00650M104   6,162    316,000    0   316,000
AG SERVICES OF AMERICA   Common   001250109   3,701    210,000    0   210,000
ALLAIRE                  Common   016714107   5,070    596,500    0   596,500
ANN TAYLOR               Common   036115103     884     23,000    0    23,000
ARADIGM                  Common   038505103   5,218    227,500    0   227,500
AREMISSOFT               Common   040026106  10,106    269,500    0   269,500
ARROW INT'L              Common   042764100  14,612    401,700    0   401,700
AVALON BAY               Common   053484101   7,420    155,600    0   155,600
AVANT                    Common   053487104  12,563    688,400    0   688,400
BEVERLY ENTERPRISE       Common   087851309   9,500  1,600,000    0 1,600,000
BINDLEY WESTERN          Common   090324104  24,742    773,200    0   773,200
BIOCHEM PHARMA           Common   09058T108  29,561  1,347,500    0 1,347,500
BJ'S WHOLESALE           Common   05548J106   1,416     41,500    0    41,500
BRIGHTPOINT              Common   109473108     503    100,000    0   100,000
BSQUARE CORPORATION      Common   11776U102   6,329    408,300    0   408,300
CARBO CERAMICS           Common   140781105   3,719    140,000    0   140,000
CARDIAC SCIENCES         Common   141410209   1,471    175,000    0   175,000
CELERA GENOMICS          Common   69332S201  10,550    105,900    0   105,900
CELL GENESYS INC         Common   150921104  22,400    746,650    0   746,650
CH ROBINSON              Common   12541W100  17,128    303,900    0   303,900
CHIEFTAIN INT'L          Common   16867C101  15,596    753,900    0   753,900
CHIRON                   Common   170040109  21,960    488,000    0   488,000
CLAYTON HOMES            Common   184190106  24,470  2,447,000    0 2,447,000
CONCORD EFS              Common   206197105  33,817    952,173    0   952,173
CORE LABS                Common   n22717107  13,991    569,600    0   569,600
CORPORATE EXEC BOARD     Common   21988R102  27,169    675,000    0   675,000
COVENTRY HEALTHCARE      Common   222862104  10,588    700,000    0   700,000
CUBIST PHARMACEUTICALS   Common   229678107  12,547    241,000    0   241,000
CYTYC CORP               Common   232946103   4,744    110,000    0   110,000
DAIN RAUSCHER            Common   233856103  24,868    267,400    0   267,400
DENTSPLY                 Common   249030107  30,972    886,500    0   886,500
DIVERSINET               Common   25536K204   5,758    980,000    0   980,000
DONALDSON                Common   257651109   5,962    271,000    0   271,000
DOVER DOWNS              Common   260086103   9,039    672,700    0   672,700
EQUITY RESIDENTIAL       Common   29476l107  42,226    879,700    0   879,700
FEDERAL REALTY           Common   313747206  14,956    782,000    0   782,000
FIDELITY NATL FINL       Common   316326107  21,778    879,920    0   879,920
FIRST WASHINGTON         Common   337489504  10,556    416,000    0   416,000
FLEMING COMPANIES        Common   339130106  12,076    924,500    0   924,500
FLIR                     Common   302445101     600    100,000    0   100,000
GENERAL COMMUNICATION    Common   369385109   4,294    600,000    0   600,000
GENESCO INC              Common   371532102  12,000    708,500    0   708,500
GENZYME                  Common   372917104  47,070    690,300    0   690,300
GILDAN ACTIVEWEAR        Common   375916103   4,149    124,300    0   124,300
HANOVER COMPRESSOR       Common   410768105  19,249    584,400    0   584,400
HEARTLAND EXPR           Common   422347104  11,373    654,583    0   654,583
HENRY SCHEIN             Common   806407102   1,886     94,600    0    94,600
HUMAN GENOME SCIENCES    Common   444903108  12,725     73,500    0    73,500
HUTCHINSON TECHNOLOGY    Common   448407106  14,617    694,000    0   694,000
IMMUNOGEN                Common   45253H101  26,820    784,500    0   784,500
INSIGHT COMM             Common   45768V108  17,915  1,128,500    0 1,128,500
INTERNET PICTURES        Common   46059S101   7,411  1,363,000    0 1,363,000
INTERNET.COM             Common   460967102  21,316    689,000    0   689,000
INVESTMENT TECHNOLOGY GP Common   46145F105  31,296    783,614    0   783,614
INVISION TECH            Common   461851107     581    150,000    0   150,000
ISIS PHARMACEUTICALS     Common   464330109   6,900    600,000    0   600,000
IVILLAGE                 Common   46588H105   5,411  1,396,500    0 1,396,500
JEFFERIES GROUP          Common   472319102  18,119    674,200    0   674,200
JONES APPAREL GROUP      Common   480074103  27,653  1,043,500    0 1,043,500
KEY3MEDIA GROUP          Common   49326R104   4,875    445,700    0   445,700
LANDS' END               Common   515086106   2,100    100,000    0   100,000
LEARNING TREE            Common   522015106  20,945    439,800    0   439,800
LEGG MASON               Common   524901105     552      9,500    0     9,500
LINDSAY MFG              Common   535555106   9,536    512,000    0   512,000
LINENS N THINGS          Common   535679104  13,497    529,300    0   529,300
M S CARRIERS             Common   553533100   4,113    263,200    0   263,200
MACROVISION              Common   555904101  14,726    181,800    0   181,800
MANUFACT HOME            Common   564682102  24,081    963,250    0   963,250
MARCUS                   Common   566330106   7,073    673,600    0   673,600
MARIMBA                  Common   56781Q109   6,183    506,000    0   506,000
MARINE DRILLING          Common   568240204   9,937    347,900    0   347,900
MAXTOR                   Common   577729205  12,647  1,204,500    0 1,204,500
MAXWELL TECHNOLOGIES     Common   577767106   6,210    342,600    0   342,600
MEAD INSTRUMENTS         Common   583062104      40      2,000    0     2,000
MEDAREX                  Common   583916101  25,703    219,100    0   219,100
MENTOR                   Common   587188103  10,789    685,000    0   685,000
METASOLV SOFTWARE        Common   591393103   5,007    122,500    0   122,500
METTLER TOLEDO           Common   592688105  46,314  1,052,600    0 1,052,600
MICHAEL'S STORES         Common   594087108   1,120     28,000    0    28,000
MID ATLANTIC MEDICAL     Common   59523C107  17,447  1,153,500    0 1,153,500
MILLENNIUM PHARM         Common   599902103  12,422     85,044    0    85,044
MKS INSTRUMENTS          Common   55306N104   7,788    284,500    0   284,500
MOLDFLOW                 Common   608507109   8,272    352,000    0   352,000
MP3.COM                  Common   62473M109     452    114,800    0   114,800
MTR GAMING               Common   553769100   1,219    150,000    0   150,000
NAUTICA ENT              Common   639089101  11,346    877,000    0   877,000
NCO GROUP                Common   628858102   3,491    294,000    0   294,000
NETRO CORP               Common   64114R109  11,376    192,000    0   192,000
NETSPEAK                 Common   64115D109   9,333    825,000    0   825,000
NEW HORIZONS             Common   645526104   3,780    315,000    0   315,000
OAK TECHNOLOGY           Common   671802106  27,646  1,009,900    0 1,009,900
ON COMMAND               Common   682160106   4,360    355,000    0   355,000
OPTIMAL ROBOTICS         Common   68388R208  16,503    410,000    0   410,000
OSHKOSH TRUCKING         Common   688239201  17,374    448,350    0   448,350
PACIFIC SUNWEAR          Common   694873100   1,313     70,000    0    70,000
PALM HARBOR HMS          Common   696639103  13,483    980,561    0   980,561
PENN NATIONAL GAMING     Common   707569109   1,294     85,000    0    85,000
PETSMART                 Common   716768106   6,305  1,345,000    0 1,345,000
PHILLIPS VAN HEUSEN CP   Common   718592108   9,141    886,400    0   886,400
PLANTRONICS              Common   727493108  26,790    705,000    0   705,000
POLARIS                  Common   731068102  18,263    518,100    0   518,100
POLYCOM                  Common   73172K104  31,442    469,500    0   469,500
POLYMER GROUP            Common   731745105   5,996    813,000    0   813,000
PRENTISS PROPERTIES      Common   740706106   5,606    214,600    0   214,600
QUANTUM                  Common   747906303  10,022  1,008,500    0 1,008,500
QUICKSILVER              Common   74838C106     943     49,000    0    49,000
RAINBOW  TECHNOLOGIES    Common   750862104     955     27,000    0    27,000
REGENCY REALTY           Common   758939102  24,272  1,058,200    0 1,058,200
REGENERON                Common   75886F107  21,875    670,500    0   670,500
REGIS                    Common   758932107  14,198    946,500    0   946,500
SAGA SYSTEMS             Common   786610105   1,155    110,000    0   110,000
SAUL CENTERS             Common   804395101   6,166    386,900    0   386,900
SCP POOL                 Common   784028102   1,037     35,000    0    35,000
SEACHANGE                Common   811699107  13,796    413,350    0   413,350
SHOPKO                   Common   824911101   2,961    285,400    0   285,400
SILICON IMAGE INC        Common   82705T102   7,667    309,000    0   309,000
SILVERSTREAM SOFTWARE    Common   827907106   7,110    236,000    0   236,000
SIPEX                    Common   829909100  12,282    292,000    0   292,000
SPECTRALINK              Common   847580107   4,992    529,000    0   529,000
ST MARY LAND&EX          Common   792228108  24,239   ,051,000    0 1,051,000
STYLECLICK               Common   86422L102   3,966    417,500    0   417,500
SUN COMMUNITIES          Common   866674104  30,706    970,950    0   970,950
SWIFT TRANSN             Common   870756103   3,912    299,450    0   299,450
SYBASE                   Common   871130100  21,871    950,900    0   950,900
SYBRON                   Common   87114F106  11,280    470,000    0   470,000
TIDEWATER                Common   886423102  17,063    375,000    0   375,000
TOO INC                  Common   890333107  16,601    699,000    0   699,000
TRANSKARYOTIC THERAPIES  Common   893735100   4,845    112,500    0   112,500
TREX CO                  Common   89531P105     970     32,000    0    32,000
TRIMBLE NAVIGATION       Common   896239100   6,344    283,550    0   283,550
TULARIK INC              Common   899165104  18,071    547,600    0   547,600
TUT SYSTEMS              Common   901103101     259      3,000    0     3,000
UNIT                     Common   909218109  10,981    744,500    0   744,500
VALMONT                  Common   920253101  10,238    515,100    0   515,100
VALUEVISION              Common   92047K107  14,786    588,500    0   588,500
VARIAN SEMICONDUCTOR     Common   922207105     749     20,000    0    20,000
VERITY                   Common   92343c106  21,520    603,000    0   603,000
VERTEX PHARM             Common   92532F100  46,264    547,500    0   547,500
WATERS CORP              Common   941848103  19,883    223,400    0   223,400
WERNER ENTERPRISES       Common   950755108   3,807    324,000    0   324,000
WESTERN DIGITAL          Common   958102105  12,440  2,117,500    0 2,117,500
WILLIAMS SONOMA          Common   969904101     417     12,000    0    12,000
WINK COMMUNICATIONS      Common   974168106   6,480    540,000    0   540,000
ZALE CORP                Common   988858106     876     27,000    0    27,000
ZYGO                     Common   989855101  21,419    246,200    0   246,200
</TABLE>
Report Summary:

Number of Other Included Managers:        None

Form 13F Information Table Entry Total:   151

Information Table Value                   $2,128 million



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