<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE BALANCE
SHEET OF EPIX MEDICAL, INC AS OF JUNE 30, 2000 AND FOR THE SIX MONTH PERIOD
ENDED JUNE 30, 2000 AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH
FINANCIAL STATEMENTS.
</LEGEND>
<CIK> 0001027702
<NAME> EPIX MEDICAL, INC
<MULTIPLIER> 1
<CURRENCY> U.S.DOLLARS

<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-2000
<PERIOD-START>                             JAN-01-2000
<PERIOD-END>                               JUN-30-2000
<EXCHANGE-RATE>                                      1
<CASH>                                         943,214
<SECURITIES>                                32,081,983
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                            34,205,993
<PP&E>                                       4,486,528
<DEPRECIATION>                             (2,897,980)
<TOTAL-ASSETS>                              36,291,422
<CURRENT-LIABILITIES>                       10,680,858
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       129,604
<OTHER-SE>                                  22,377,166
<TOTAL-LIABILITY-AND-EQUITY>                36,291,422
<SALES>                                              0
<TOTAL-REVENUES>                             3,146,129
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                            12,989,000
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             199,487
<INCOME-PRETAX>                            (9,731,002)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                        (9,731,002)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                         0
<EPS-BASIC>                                     (0.83)
<EPS-DILUTED>                                   (0.83)


</TABLE>



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