EPIX MEDICAL INC
SC 13G/A, 2000-02-14
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G
                                 (Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c)
           AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)
                               (Amendment No. 1)*

                               EPIX Medical, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    26881Q101
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

             [ ]     Rule 13d-1(b)

             [ ]     Rule 13d-1(c)

             [X]     Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                         (Continued on following pages)

                                  Page 1 of 20
                            Exhibit Index on Page 18


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 2 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Accel IV L.P. ("A4")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  645,886 shares,  except that Accel IV Associates
      SHARES                    L.P. ("A4A"),  the general partner of A4, may be
    BENEFICIALLY                deemed to have sole power to vote these  shares,
   OWNED BY EACH                and  Swartz  Family  Partnership  L.P.  ("SFP"),
     REPORTING                  James  W.  Breyer  ("Breyer"),   Luke  B.  Evnin
      PERSON                    ("Evnin"), Eugene D. Hill, III ("Hill"), Paul H.
       WITH                     Klingenstein    ("Klingenstein"),    Arthur   C.
                                Patterson  ("Patterson"),   G.  Carter  Sednaoui
                                ("Sednaoui") and James R. Swartz ("Swartz"), the
                                general  partners of A4A,  may be deemed to have
                                shared power to vote these shares.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                See response to row 5.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                645,886  shares,  except  that A4A,  the general
                                partner  of A4, may be deemed to have sole power
                                to dispose  of these  shares,  and SFP,  Breyer,
                                Evnin, Hill, Klingenstein,  Patterson,  Sednaoui
                                and Swartz,  the general partners of A4A, may be
                                deemed to have shared  power to dispose of these
                                shares.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                See response to row 7.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       645,886
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.5%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              PN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 3 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Accel IV Associates L.P. ("A4A")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  645,886 shares,  all of which are directly owned
      SHARES                    by  Accel  IV  L.P.  ("A4").  A4A,  the  general
    BENEFICIALLY                partner  of A4, may be deemed to have sole power
   OWNED BY EACH                to  vote  these   shares,   and  Swartz   Family
     REPORTING                  Partnership  L.P.   ("SFP"),   James  W.  Breyer
      PERSON                    ("Breyer"),  Luke B. Evnin ("Evnin"),  Eugene D.
       WITH                     Hill,   III  ("Hill"),   Paul  H.   Klingenstein
                                ("Klingenstein"),     Arthur    C.     Patterson
                                ("Patterson"),  G. Carter Sednaoui  ("Sednaoui")
                                and  James R.  Swartz  ("Swartz"),  the  general
                                partners  of A4A,  may be deemed to have  shared
                                power to vote these shares.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                See response to row 5.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                645,886 shares,  all of which are directly owned
                                by A4. A4A,  the  general  partner of A4, may be
                                deemed to have sole  power to  dispose  of these
                                shares,   and   SFP,   Breyer,    Evnin,   Hill,
                                Klingenstein,  Patterson,  Sednaoui  and Swartz,
                                the general  partners  of A4A,  may be deemed to
                                have shared power to dispose of these shares.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                See response to row 7.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       645,886
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.5%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              PN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 4 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Accel Keiretsu L.P. ("AK")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  13,396 shares,  except that Accel Partners & Co.
      SHARES                    Inc. ("AP&C"), the general partner of AK, may be
    BENEFICIALLY                deemed to have sole power to vote these  shares,
   OWNED BY EACH                and James W.  Breyer  ("Breyer"),  Luke B. Evnin
     REPORTING                  ("Evnin"),  Eugene D. Hill, III ("Hill"), Arthur
      PERSON                    C. Patterson  ("Patterson"),  G. Carter Sednaoui
       WITH                     ("Sednaoui") and James R. Swartz ("Swartz"), the
                                officers of AP&C, may be  deemed  to have shared
                                power to vote these shares.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                See response to row 5.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                13,396  shares,  except  that AP&C,  the general
                                partner  of AK, may be deemed to have sole power
                                to dispose of these shares,  and Breyer,  Evnin,
                                Hill,   Patterson,   Sednaoui  and  Swartz,  the
                                officers  of AP&C,  may be deemed to have shared
                                power to dispose of these shares.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                See response to row 7.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       13,396
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    0.1%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              PN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 5 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Accel Partners & Co. Inc. ("AP&C")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  13,587  shares,  13,396  of which  are  directly
      SHARES                    owned by Accel Keiretsu L.P.  ("AK").  AP&C, the
    BENEFICIALLY                general  partner  of AK,  may be  deemed to have
   OWNED BY EACH                sole  power to vote these  shares,  and James W.
     REPORTING                  Breyer  ("Breyer"),  Luke  B.  Evnin  ("Evnin"),
      PERSON                    Eugene  D.  Hill,   III   ("Hill"),   Arthur  C.
       WITH                     Patterson  ("Patterson"),   G.  Carter  Sednaoui
                                ("Sednaoui") and James R. Swartz ("Swartz"), the
                                officers  of AP&C,  may be deemed to have shared
                                power to vote these shares.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                See response to row 5.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                13,587  shares,  13,396  of which  are  directly
                                owned by AK.  AP&C,  the general  partner of AK,
                                may be deemed to have sole  power to  dispose of
                                these   shares,   and   Breyer,   Evnin,   Hill,
                                Patterson,  Sednaoui and Swartz, the officers of
                                AP&C,  may be  deemed  to have  shared  power to
                                dispose of these shares.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                See response to row 7.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       13,587
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    0.1%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              CO
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 6 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Accel Investors '93 L.P. ("AI93")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  26,088  shares,  except  that  James  W.  Breyer
      SHARES                    ("Breyer"),  Luke B.  Evnin  ("Evnin"),  Paul H.
    BENEFICIALLY                Klingenstein    ("Klingenstein"),    Arthur   C.
   OWNED BY EACH                Patterson  ("Patterson"),   G.  Carter  Sednaoui
     REPORTING                  ("Sednaoui") and James R. Swartz ("Swartz"), the
      PERSON                    general  partners of AI93, may be deemed to have
       WITH                     shared power to vote these shares.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                See response to row 5.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                26,088  shares,   except  that  Breyer,   Evnin,
                                Klingenstein,  Patterson,  Sednaoui  and Swartz,
                                the general  partners of AI93,  may be deemed to
                                have shared power to dispose of these shares.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                See response to row 7.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       26,088
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    0.2%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              PN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 7 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Swartz Family Partnership L.P. ("SFP")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             Delaware
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  23,512 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED  VOTING  POWER See response
      PERSON                    645,886 shares,  all of which are directly owned
       WITH                     by Accel IV L.P. PERSON ("A4"). SFP is a general
                                partner of Accel IV Associates  L.L.C.  ("A4A"),
                                the general  partner of A4, and may be deemed to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                23,512 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                645,886 shares,  all of which are directly owned
                                by A4.  SFP is a  general  partner  of A4A,  the
                                general partner of A4, and may be deemed to have
                                shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       669,398
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.7%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              PN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 8 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      James W. Breyer ("Breyer")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  31,892 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED  VOTING  POWER See response
      PERSON                    685,561  shares,  of which  645,886 are directly
       WITH                     owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly  owned by Accel  Keiretsu L.P.  ("AK"),
                                26,088 are directly owned by Accel Investors '93
                                L.P.  ("AI93")  and 191 are  directly  owned  by
                                Accel Partners & Co. Inc. ("AP&C").  Breyer is a
                                general  partner of Accel IV  Associates  L.L.C.
                                ("A4A"),  the general  partner of A4, an officer
                                of  AP&C,  the  general  partner  of  AK,  and a
                                general  partner  of AI93 and may be  deemed  to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                31,892 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                685,561  shares,  of which  645,886 are directly
                                owned by A4,  13,396 are  directly  owned by AK,
                                26,088  are  directly  owned by AI93 and 191 are
                                directly  owned by  AP&C.  Breyer  is a  general
                                partner of A4A,  the general  partner of A4, and
                                an officer of AP&C,  the general  partner of AK,
                                and a general  partner of AI93 and may be deemed
                                to have shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       717,453
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    6.2%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G             Page 9 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Luke B. Evnin ("Evnin")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  26,366 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED  VOTING  POWER See response
      PERSON                    685,561  shares,  of which  645,886 are directly
       WITH                     owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly  owned by Accel  Keiretsu L.P.  ("AK"),
                                26,088 are directly owned by Accel Investors `93
                                L.P.  ("AI93")  and 191 are  directly  owned  by
                                Accel Partners & Co. Inc.  ("AP&C").  Evnin is a
                                general  partner of Accel IV  Associates  L.L.C.
                                ("A4A"),  the  general  partner  of  A4,  and an
                                officer of AP&C, the general  partner of AK, and
                                a general  partner  of AI93 and may be deemed to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                26,366 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                685,561  shares,  of which  645,886 are directly
                                owned by A4,  13,396 are  directly  owned by AK,
                                26,088  are  directly  owned by AI93 and 191 are
                                directly  owned  by  AP&C.  Evnin  is a  general
                                partner of A4A,  the general  partner of A4, and
                                an officer of AP&C,  the general  partner of AK,
                                and a general  partner of AI93 and may be deemed
                                to have shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       711,927
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    6.1%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G            Page 10 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Eugene D. Hill, III ("Hill")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  3,662 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED  VOTING  POWER See response
      PERSON                    659,473  shares,  of which  645,886 are directly
       WITH                     owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly owned by Accel Keiretsu L.P. ("AK") and
                                191 are directly  owned by Accel  Partners & Co.
                                Inc.  ("AP&C").  Hill is a  general  partner  of
                                Accel IV Associates L.L.C.  ("A4A"), the general
                                partner  of A4,  and an  officer  of  AP&C,  the
                                general partner of AK, and may be deemed to have
                                shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                3,662 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                659,473  shares,  of which  645,886 are directly
                                owned by A4, 13,396 are directly owned by AK and
                                191 are  directly  owned  by AP&C.  Breyer  is a
                                general  partner of A4A, the general  partner of
                                A4, and an officer of AP&C, the general  partner
                                of AK, and may be deemed to have shared power to
                                dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       663,135
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.7%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G            Page 11 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Paul H. Klingenstein ("Klingenstein")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  18,992 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED  VOTING  POWER See response
      PERSON                    671,974  shares,  of which  645,886 are directly
       WITH                     owned by Accel IV L.P.  ("A4")  and  26,088  are
                                directly  owned  by  Accel  Investors  '93  L.P.
                                ("AI93").  Klingenstein  is a general partner of
                                Accel IV Associates L.L.C.  ("A4A"), the general
                                partner of A4, and a general partner of AI93 and
                                may be deemed to have shared power to vote these
                                shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                18,992 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                671,974  shares,  of which  645,886 are directly
                                owned by A4 and  26,088  are  directly  owned by
                                AI93. Klingenstein is a general partner of Accel
                                IV  Associates  L.L.C.   ("A4A"),   the  general
                                partner of A4, and a general partner of AI93 and
                                may be deemed to have shared power to dispose of
                                these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       690,966
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.9%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G            Page 12 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      Arthur C. Patterson ("Patterson")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  208,506  shares,  of  which  34,897  shares  are
      SHARES                    directly owned by Ellmore C. Patterson  Partners
    BENEFICIALLY                ("ECPP").  Patterson  is the general  partner of
   OWNED BY EACH                ECPP and may be  deemed  to have  sole  power to
     REPORTING                  vote the shares held by ECPP.
      PERSON
       WITH            -------- ------------------------------------------------
                       6        SHARED  VOTING  POWER See response
                                685,561  shares,  of which  645,886 are directly
                                owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly  owned by Accel  Keiretsu L.P.  ("AK"),
                                26,088 are directly owned by Accel Investors '93
                                L.P.  ("AI93")  and 191 are  directly  owned  by
                                Accel Partners & Co. Inc. ("AP&C"). Patterson is
                                a general partner of Accel IV Associates  L.L.C.
                                ("A4A"),  the  general  partner  of  A4,  and an
                                officer of AP&C, the general  partner of AK, and
                                a general  partner  of AI93 and may be deemed to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                208,506  shares,  of  which  34,897  shares  are
                                directly owned by Ellmore C. Patterson  Partners
                                ("ECPP").  Patterson  is the general  partner of
                                ECPP and may be  deemed  to have  sole  power to
                                dispose of the shares held by ECPP.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                685,561  shares,  of which  645,886 are directly
                                owned by A4,  13,396 are  directly  owned by AK,
                                26,088  are  directly  owned by AI93 and 191 are
                                directly  owned by AP&C.  Patterson is a general
                                partner of A4A,  the general  partner of A4, and
                                an officer of AP&C,  the general  partner of AK,
                                and a general  partner of AI93 and may be deemed
                                to have shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       894,067
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    7.7%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G            Page 13 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      G. Carter Sednaoui ("Sednaoui")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  7,560 shares
      SHARES
    BENEFICIALLY
   OWNED BY EACH       -------- ------------------------------------------------
     REPORTING         6        SHARED VOTING POWER
      PERSON                    685,561  shares,  of which  645,886 are directly
       WITH                     owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly  owned by Accel  Keiretsu L.P.  ("AK"),
                                26,088 are directly owned by Accel Investors '93
                                L.P.  ("AI93")  and 191 are  directly  owned  by
                                Accel Partners & Co. Inc. ("AP&C").  Sednaoui is
                                a general partner of Accel IV Associates  L.L.C.
                                ("A4A"),  the general  partner of A4, an officer
                                of  AP&C,  the  general  partner  of  AK,  and a
                                general  partner  of AI93 and may be  deemed  to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                7,560 shares


                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                685,561  shares,  of which  645,886 are directly
                                owned by A4,  13,396 are  directly  owned by AK,
                                26,088  are  directly  owned by AI93 and 191 are
                                directly  owned by AP&C.  Sednaoui  is a general
                                partner of A4A,  the general  partner of A4, and
                                an officer of AP&C,  the general  partner of AK,
                                and a general  partner of AI93 and may be deemed
                                to have shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       693,121
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    5.9%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


- ------------------------------------                     -----------------------
CUSIP NO. 483600102                          13 G            Page 14 of 21 Pages
- ------------------------------------                     -----------------------

- ------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                      James R. Swartz ("Swartz")
                      Tax ID Number:
- ------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)  [ ]      (b)  [X]
- ------------ -------------------------------------------------------------------
3            SEC USE ONLY
- ------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
- ------------------------------------ -------- ----------------------------------
                       5        SOLE VOTING POWER
     NUMBER OF                  81,349  shares,  of  which  14,290  shares   are
      SHARES                    directly  owned by the Swartz  Foundation  Trust
    BENEFICIALLY                ("SFT"),  of which  Swartz is the  trustee,  and
   OWNED BY EACH                23,512  shares are directly  owned by the Swartz
     REPORTING                  Family Partnership L.P. ("SFP"), of which Swartz
      PERSON                    is the general partner.  Swartz may be deemed to
       WITH                     have sole power to vote the  shares  held by SFT
                                and SFP.

                       -------- ------------------------------------------------
                       6        SHARED VOTING POWER
                                685,561  shares,  of which  645,886 are directly
                                owned  by  Accel  IV  L.P.  ("A4"),  13,396  are
                                directly  owned by Accel  Keiretsu L.P.  ("AK"),
                                26,088 are directly owned by Accel Investors '93
                                L.P.  ("AI93")  and 191 are  directly  owned  by
                                Accel Partners & Co. Inc. ("AP&C").  Swartz is a
                                general  partner of Accel IV  Associates  L.L.C.
                                ("A4A"),  the general  partner of A4, an officer
                                of  AP&C,  the  general  partner  of  AK,  and a
                                general  partner  of AI93 and may be  deemed  to
                                have shared power to vote these shares.

                       -------- ------------------------------------------------
                       7        SOLE DISPOSITIVE POWER
                                81,349  shares,  of  which  14,290  shares   are
                                directly  owned by SFT,  of which  Swartz is the
                                trustee, and 23,512 shares are directly owned by
                                SFP,  of which  Swartz is the  general  partner.
                                Swartz  may be  deemed  to have  sole  power  to
                                dispose of the shares held by SFT and SFP.

                       -------- ------------------------------------------------
                       8        SHARED DISPOSITIVE POWER
                                685,561  shares,  of which  645,886 are directly
                                owned by A4,  13,396 are  directly  owned by AK,
                                26,088  are  directly  owned by AI93 and 191 are
                                directly  owned by  AP&C.  Swartz  is a  general
                                partner of A4A,  the general  partner of A4, and
                                an officer of AP&C,  the general  partner of AK,
                                and a general  partner of AI93 and may be deemed
                                to have shared power to dispose of these shares.

- ------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                       766,910
- ------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                   [ ]
- ------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                    6.6%
- ------------ -------------------------------------------------------------------
12           TYPE OR REPORTING PERSON*                              IN
- ------------ -------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                                   Page 15 of 21

ITEM 1(A).        NAME OF ISSUER

                  EPIX Medical, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                  71 Rogers Street
                  Cambridge, MA  02142

ITEM 2(A).        NAME OF PERSONS FILING

                  This  Statement is filed by Accel IV L.P., a Delaware  limited
                  partnership  ("A4"),  Accel IV  Associates  L.P.,  a  Delaware
                  limited  partnership  and the  general  partner of A4 ("A4A"),
                  Accel Keiretsu L.P., a Delaware  limited  partnership  ("AK"),
                  Accel  Partners & Co.  Inc.,  a Delaware  corporation  and the
                  general  partner of AK ("AP&C"),  Accel  Investors '93 L.P., a
                  Delaware  limited  partnership  ("AI93"),  the  Swartz  Family
                  Partnership L.P. ("SFP"), a Delaware limited partnership and a
                  general partner of A4A, James W. Breyer ("Breyer"),  a general
                  partner of A4A,  an  officer of AP&C and a general  partner of
                  AI93,  Luke B. Evnin  ("Evnin"),  a general partner of A4A, an
                  officer of AP&C and a general partner of AI93, Eugene D. Hill,
                  III ("Hill"), a general partner of A4A and an officer of AP&C,
                  Paul H.  Klingenstein  ("Klingenstein"),  a general partner of
                  A4A  and a  general  partner  of  AI93,  Arthur  C.  Patterson
                  ("Patterson"),  a general  partner of A4A,  an officer of AP&C
                  and  a  general   partner   of  AI93,   G.   Carter   Sednaoui
                  ("Sednaoui"), a general partner of A4A, an officer of AP&C and
                  a general partner of AI93, and James R. Swartz  ("Swartz"),  a
                  general  partner  of A4A,  an  officer  of AP&C and a  general
                  partner of AI93. The foregoing  entities and  individuals  are
                  collectively referred to as the "Reporting Persons."

                  A4A,  the  general  partner  of A4, may be deemed to have sole
                  power to vote  and sole  power to  dispose  of  shares  of the
                  issuer  directly owned by A4. AP&C, the general partner of AK,
                  may be  deemed to have  sole  power to vote and sole  power to
                  dispose of shares of the  issuer  directly  owned by AK.  SFP,
                  Breyer,  Evnin, Hill,  Klingenstein,  Patterson,  Sednaoui and
                  Swartz are  partners  of A4A and may be deemed to have  shared
                  power to vote and  shared  power to  dispose  of shares of the
                  issuer directly owned by A4. Breyer,  Evnin, Hill,  Patterson,
                  Sednaoui  and Swartz are officers of AP&C and may be deemed to
                  have  shared  power to vote and  shared  power to  dispose  of
                  shares of the  issuer  directly  owned by AK.  Breyer,  Evnin,
                  Klingenstein,  Patterson,  Sednaoui and Swartz are partners of
                  AI93 and may be  deemed  to have  sole  power to vote and sole
                  power to  dispose of shares of the  issuer  directly  owned by
                  AI93.

ITEM 2(B).        ADDRESS OF PRINCIPAL OFFICE

                  The address for each of the Reporting Persons is:

                  Accel Partners
                  428 University Ave.
                  Palo Alto, California  94301

ITEM 2(C)         CITIZENSHIP

                  A4, A4A, AK, AI93 and SFP are Delaware  limited  partnerships.
                  AP&C  is  a  Delaware   corporation.   Breyer,   Evnin,  Hill,
                  Klingenstein, Patterson, Sednaoui and Swartz are United States
                  citizens.

ITEM 2(D) AND (E).         TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER

                  Common Stock
                  CUSIP # 26881Q101


<PAGE>


                                                                   Page 16 of 21

ITEM 3.    Not Applicable

ITEM 4.    OWNERSHIP

           The following information with respect to the ownership of the
           Common  Stock  of  the  issuer  by  the  persons  filing  this
           Statement is provided as of December 31, 1999:

            (a)  Amount beneficially owned:

                 See Row 9 of cover page for each Reporting Person.

            (b)  Percent of Class:

                 See Row 11 of cover page for each Reporting Person.

            (c)  Number of shares as to which such person has:

                 (i)    Sole power to vote or to direct the vote:

                        See Row 5 of cover page for each Reporting Person.

                 (ii)   Shared power to vote or to direct the vote:

                        See Row 6 of cover page for each Reporting Person.

                 (iii)  Sole power to dispose or to direct the disposition of:

                        See Row 7 of cover page for each Reporting Person.

                 (iv)   Shared power to dispose or to direct the disposition of:

                        See Row 8 of cover page for each Reporting Person.

ITEM 5.    OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

           Not applicable.

ITEM 6.    OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

           Under  certain  circumstances  set forth in the  limited  partnership
           agreements of A4, A4A, AK and AI93,  and the  operating  agreement of
           AP&C, the general and limited partners or  stockholders,  as the case
           may be, of each of such  entities  may be deemed to have the right to
           receive  dividends  from, or the proceeds from, the sale of shares of
           the issuer owned by each such entity of which they are a partner.

ITEM 7.    IDENTIFICATION  AND  CLASSIFICATION  OF THE SUBSIDIARY WHICH ACQUIRED
           THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

           Not applicable.


<PAGE>


                                                                   Page 17 of 21

ITEM 8.    IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

           Not applicable

ITEM 9.    NOTICE OF DISSOLUTION OF GROUP.

           Not applicable

ITEM 10.   CERTIFICATION.

           Not applicable


<PAGE>


                                                                   Page 18 of 21

                                   SIGNATURES

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Date:  February 14, 2000

Entities:     Accel IV L.P.
              Accel IV Associates L.P.
              Accel Keiretsu L.P.
              Accel Investors '93 L.P.
              Accel Partners & Co. Inc.
              Swartz Family Partnership L.P.      By:  /s/ G. Carter Sednaoui
                                                     ---------------------------
                                                       G. Carter Sednaoui,
                                                       Attorney-in-fact for the
                                                       above-listed entities

Individuals:  James W. Breyer
              Luke. B. Evnin
              Eugene D. Hill, III
              Paul H. Klingenstein
              Arthur C. Patterson
              G. Carter Sednaoui
              James R. Swartz                     By:  /s/ G. Carter Sednaoui
                                                     ---------------------------
                                                       G. Carter Sednaoui,
                                                       Attorney-in-fact for the
                                                       above-listed individuals


<PAGE>


                                                                   Page 19 of 21

                                  EXHIBIT INDEX

                                                                     Found on
                                                                   Sequentially
Exhibit                                                            Numbered Page
- -------                                                            -------------

Exhibit A:  Agreement of Joint Filing                                   20


Exhibit B:  Reference to G. Carter Sednaoui as Attorney-in-Fact         21


<PAGE>


                                                                   Page 20 of 21

                                    EXHIBIT A

                            Agreement of Joint Filing

                  The Reporting  Persons have agreed that a single  Schedule 13G
(or any amendment  thereto)  relating to the Common Stock of EPIX Medical,  Inc.
shall be filed on behalf of each of the Reporting Persons. Note that a copies of
the  applicable  Agreement  of  Joint  Filing  are  already  on  file  with  the
appropriate agencies.


<PAGE>


                                                                   Page 21 of 21

                                    EXHIBIT B

              Reference to G. Carter Sednaoui as Attorney-in-Fact

                  G.  Carter  Sednaoui  has signed  the  enclosed  documents  as
Attorney-In-Fact.  Note that copies of the  applicable  Power of  Attorneys  are
already on file with the appropriate agencies.



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