ORAPHARMA INC
S-8, 2000-06-29
PHARMACEUTICAL PREPARATIONS
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<PAGE>

     As filed with the Securities and Exchange Commission on June 29, 2000
                                                      Registration No. 333-
================================================================================


                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                _______________


                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933

                                _______________


                                ORAPHARMA, INC.
              (Exact name of company as specified in its charter)

              Delaware                                22-3473777
    (State or Other Jurisdiction of      (I.R.S. Employer Identification No.)
     Incorporation or Organization)

           732 Louis Drive
       Warminster, Pennsylvania                         18974
(Address of principal executive offices)              (Zip Code)

                                OraPharma, Inc.
                         1999 Equity Compensation Plan
                           (Full title of the plan)

                             Michael D. Kishbauch
                     President and Chief Executive Officer
                                OraPharma, Inc.
                                732 Louis Drive
                        Warminster, Pennsylvania  18974
                    (Name and address of agent for service)

                                (215) 956-2200
         (Telephone number, including area code, of agent for service)

                                _______________


                        Copy of all communications to:
                                 David R. King
                          Morgan, Lewis & Bockius LLP
                              1701 Market Street
                     Philadelphia, Pennsylvania 19103-2921
                                (215) 963-5000

                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
=============================================================================================================
                                             Proposed maximum    Proposed maximum
   Title of securities      Amount to be      offering price        aggregate              Amount of
     to be registered      registered (1)      per share (2)    offering price (2)  registration fee (2) (3)
-------------------------------------------------------------------------------------------------------------
<S>                        <C>               <C>                <C>                 <C>
Common Stock, $0.001 par     1,250,000       $11.94             $14,925,000             $3,940.20
 value
===========================================================================================================
</TABLE>

(1)  This Registration Statement covers shares of Common Stock of OraPharma,
     Inc. which may be offered or sold pursuant to the OraPharma, Inc. 1999
     Equity Compensation Plan. In addition, pursuant to Rule 416(c) under the
     Securities Act of 1933, as amended, this Registration Statement also covers
     an indeterminate amount of interests to be offered or sold pursuant to the
     OraPharma, Inc. 1999 Equity Compensation Plan.

(2)  Estimated pursuant to Paragraphs (c) and (h) of Rule 457 under the
     Securities Act of 1933, as amended (the "Securities Act"), solely for the
     purpose of calculating the registration fee, based upon the average of the
     high and low sales prices of shares of the Company's Common Stock on
     June 26, 2000, as reported on the Nasdaq National Market.

(3)  The registration fee of $3,940.20 is included in a wire of $3,994.64 from
     the Company.

================================================================================
<PAGE>

                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENTS

Item 3.   Incorporation of Documents by Reference.
          ---------------------------------------

          The following documents filed with the U.S. Securities and Exchange
Commission (the "Commission") by OraPharma, Inc. (the "Company") (File No. 000-
29839) pursuant to the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), are incorporated by reference in this Form S-8 Registration
Statement (the "Registration Statement") and made a part hereof:

          1.  The Company's Quarterly Report on Form 10-Q for the period ended
March 31, 2000;

          2.  The description of the Common Stock contained in the Company's
Registration Statement on Form 8-A filed on March 7, 2000; and

          3.  The Prospectus contained in the Registration Statement on Form S-
1, filed pursuant to the Securities Act of 1933, as amended (the "Securities
Act"), (file No. 333-93881) originally filed by the Company on December 30,
1999, as amended ("Form S-1"), containing audited financial statements for the
Company's financial years ended December 31, 1998 and 1999.

          All documents and reports filed by the Company pursuant to Section
13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this
Registration Statement and prior to the filing of a post-effective amendment
which indicates that all securities offered hereby have been sold or which
deregisters all securities then remaining unsold shall be deemed to be
incorporated by reference herein and to be a part hereof from the date of filing
of such documents or reports. Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such statement. Any such statement so modified shall not be deemed to
constitute a part of the Registration Statement except as so modified and any
statement so superseded shall not be deemed to constitute a part of this
Registration Statement.

Independent Public Accountants
------------------------------

          The financial statements contained in the Company's Form S-1,
incorporated by reference in this Registration Statement have been audited by
Arthur Andersen LLP, independent public accountants, as indicated in their
report with respect thereto, and are included herein in reliance upon the
authority of said firm as experts in giving said report.

                                      II-1
<PAGE>



Item 4.   Description of Securities.
          -------------------------

          Not Applicable

Item 5.   Interests of Named Experts and Counsel.
          --------------------------------------

          Not Applicable

Item 6.   Indemnification of Directors and Officers.
          -----------------------------------------

          The Company's Certificate of Incorporation permits indemnification to
the fullest extent permitted by Delaware law. The Company's by-laws require the
Company to indemnify any person who was or is an authorized representative of
the Company, and who was or is a party or is threatened to be made a party to
any corporate proceeding, by reason of the fact that such person was or is an
authorized representative of the Company, against expenses, judgments,
penalties, fines and amounts paid in settlement actually and reasonably incurred
by such person in connection with such third-party proceeding if such person
acted in good faith and in a manner such person reasonably believed to be in, or
not opposed to, the best interests of the Company and, with respect to any
criminal third-party proceeding (including any action or investigation which
could or does lead to a criminal third-party proceeding) had no reasonable cause
to believe such conduct was unlawful. The Company shall also indemnify any
person who was or is an authorized representative of the Company and who was or
is a party or is threatened to be made a party to any corporate proceeding by
reason of the fact that such person was or is an authorized representative of
the Company, against expenses actually and reasonably incurred by such person in
connection with the defense or settlement of such corporate action if such
person acted in good faith and in a manner reasonably believed to be in, or not
opposed to, the best interests of the Company, except that no indemnification
shall be made in respect of any claim, issue or matter as to which such person
shall have been adjudged to be liable to the Company unless and only to the
extent that the Delaware Court of Chancery or the court in which such corporate
proceeding was pending shall determine upon application that, despite the
adjudication of liability but in view of all the circumstances of the

                                      II-2
<PAGE>

case, such authorized representative is fairly and reasonably entitled to
indemnity for such expenses which the Court of Chancery or such other court
shall deem proper. Such indemnification is mandatory under the Company's by-laws
as to expenses actually and reasonably incurred to the extent that an authorized
representative of the Company had been successful on the merits or otherwise in
defense of any third party or corporate proceeding or in defense of any claim,
issue or matter therein. The determination of whether an individual is entitled
to indemnification may be made by a majority of disinterested directors,
independent legal counsel in a written legal opinion or the stockholders.
Delaware law also permits indemnification in connection with a proceeding
brought by or in the right of the Company to procure a judgment in its favor.
Insofar as indemnification for liabilities arising under the Act may be
permitted to directors, officers or persons controlling the Company pursuant to
the foregoing provisions, the Company has been informed that in the opinion of
the Securities and Exchange Commission such indemnification is against public
policy as expressed in that Act and is therefore unenforceable. The Company
maintains a directors and officers liability insurance policy.

Item 7.   Exemption from Registration Claimed.
          -----------------------------------

          Not Applicable

Item 8.   Exhibits.
          ---------



          Exhibit Numbers                               Exhibit
          ----------------------------------------------------------------------

                4             Restated Certificate of Incorporation and Restated
                              By-laws of OraPharma, Inc. (incorporated by
                              reference to Exhibits 3.1 and 3.2 to Amendment No.
                              1 to OraPharma, Inc.'s Registration Statement on
                              Form S-1, filed February 7, 2000)

                5.1           Opinion of Morgan, Lewis & Bockius LLP, counsel to
                              the Company

               23.1           Consent of Arthur Andersen LLP

               23.2           Consent of Morgan, Lewis & Bockius LLP (included
                              as part of Exhibit 5.1)

               24             Power of Attorney (included as part of the
                              signature page)

                                      II-3
<PAGE>

          Exhibit Numbers                               Exhibit
          ----------------------------------------------------------------------

               99.1         OraPharma, Inc. 1999 Equity Compensation Plan
                            (incorporated by reference to Exhibit 10.2 to
                            OraPharma, Inc.'s Registration Statement on Form
                            S-1, filed December 30, 1999

Item 9.   Undertakings.
          ------------

          The undersigned hereby undertakes:

               (1)  To file, during any period in which offers or sales are
          being made, a post-effective amendment to this Registration Statement:

                    (i)     To include any prospectus required by Section
                    10(a)(3) of the Securities Act;

                    (ii)    To reflect in the Registration Statement any facts
                    or events arising after the effective date of the
                    Registration Statement (or the most recent post-effective
                    amendment thereof) which, individually or in the aggregate,
                    represent a fundamental change in the information set forth
                    in the Registration Statement. Notwithstanding the
                    foregoing, any increase or decrease in volume of securities
                    offered (if the total dollar value of securities offered
                    would not exceed that which was registered) and any
                    deviation from the low or high end of the estimated maximum
                    offering range may be reflected in the form of prospectus
                    filed with the Commission pursuant to Rule 424(b) if, in the
                    aggregate, the changes in volume and price represent no more
                    than a 20 percent change in the maximum aggregate offering
                    price set forth in the "Calculation of Registration Fee"
                    table in the effective registration statement;

                    (iii)   To include any material information with respect to
                    the plan of distribution not previously disclosed in the
                    Registration Statement or any material change to such
                    information in the Registration Statement;

          provided, however, that subparagraphs (1)(i) and (1)(ii) of this
          section do not apply if the information required to be included in a
          post-effective amendment by those subparagraphs is contained in
          periodic reports filed with or furnished to the Commission by the
          Company pursuant to Section 13 or Section 15(d) of the Exchange Act
          that are incorporated by reference in the Registration Statement.

               (2) That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement

                                      II-4

<PAGE>

          relating to the securities offered therein, and the offering of such
          securities at that time shall be deemed to be the initial bona fide
          offering thereof.

               (3) To remove from registration by means of a post-effective
          amendment any of the securities being registered that remain unsold at
          the termination of the offering.

          The undersigned company hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the Company's
annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act
(and each filing of the OraPharma, Inc. 1999 Equity Compensation Plan annual
report pursuant to Section 15(d) of the Securities Act) that is incorporated by
reference in this Registration Statement shall be deemed to be a new
Registration Statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

          Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Company pursuant to the foregoing provisions, or otherwise, the Company
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Company of expenses incurred or paid
by a director, officer or controlling person of the Company in the successful
defense of any action, suit or proceeding) is asserted by such director, officer
or controlling person in connection with the securities being registered, the
Company will, unless in the opinion of its counsel the matter has been settled
by controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication
of such issue.

                                      II-5
<PAGE>

                                  SIGNATURES

          Pursuant to the requirements of the Securities Act of 1933, the
Company certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in Warminster, Commonwealth of Pennsylvania on this 29th day of
June, 2000.

                                    ORAPHARMA, INC.


                                    By: /s/    Michael D. Kishbauch
                                        _____________________________
                                        Name:  Michael D. Kishbauch
                                        Title: President and Chief
                                               Executive Officer

          Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by or on behalf of the following persons in the
capacities and on the dates indicated.

          Each person, in so signing, also makes, constitutes and appoints
Michael D. Kishbauch and James A. Ratigan, and each such officer acting singly,
his true and lawful attorney-in-fact, in his name, place and stead to execute
and cause to be filed with the Securities and Exchange Commission any or all
amendments to this Registration Statement, with all exhibits and any and all
documents required to be filed with respect thereto, and to do and perform each
and every act and thing necessary to effectuate the same.

Name                    Title                            Date
----                    -----                            ----

/s/ Michael D. Kishbauch  President, Chief Executive       June 29, 2000
------------------------  Officer, and Director
Michael D. Kishbauch      (Principal Executive Officer)

/s/ James A. Ratigan      Executive Vice President,        June 29, 2000
----------------------    Chief Financial Officer and
James A. Ratigan          Secretary (Principal Financial
                          Officer)

/s/ Robert D. Haddow      Controller (Principal            June 29, 2000
----------------------    Accounting Officer)
Robert D. Haddow

/s/ James J. Mauzey                  Director              June 29, 2000
----------------------
James J. Mauzey

/s/ Christopher Moller               Director              June 29, 2000
----------------------
Christopher Moller

/s/ Eileen M. More                   Director              June 29, 2000
----------------------
Eileen M. More

/s/ Harry T. Rein                    Director              June 29, 2000
----------------------
Harry T. Rein

/s/ Seth A. Rudnick                  Director              June 29, 2000
----------------------
Seth A. Rudnick

/s/ David I. Scheer                  Director              June 29, 2000
----------------------
David I. Scheer

/s/ Jesse I. Treu                    Director              June 29, 2000
----------------------
Jesse I. Treu

<PAGE>

                               INDEX TO EXHIBITS


Exhibit Numbers                                Exhibit
-------------------------------------------------------------------------------

       4       Fourth Amended and Restated Certificate of Incorporation and
               Amended and Restated By-laws of OraPharma, Inc. (incorporated by
               reference to Exhibits 3.1 and 3.2, respectively, to Amendment No.
               1 to OraPharma, Inc.'s Registration Statement on Form S-1, filed
               on February 7, 2000)

       5.1     Opinion of Morgan, Lewis & Bockius LLP, counsel to the Company

      23.1     Consent of Arthur Andersen LLP

      23.2     Consent of Morgan, Lewis & Bockius LLP (included as part of
               Exhibit 5.1)

      24       Power of Attorney (included as part of the signature page)

      99.1     OraPharma, Inc. 1999 Equity Compensation Plan (incorporated by
               reference to Exhibit 10.2 to OraPharma, Inc.'s Registration
               Statement on Form S-1, filed December 30, 1999


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