<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SECTION CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM ORAPHARMA,
INC'S SEPTEMBER 30, 2000 CONSOLIDATED FINANCIAL STATEMENTS AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH CONSOLIDATED FINANCIAL STATEMENTS.
</LEGEND>
<CIK> 0001028065
<NAME> ORAPHARMA, INC.
<MULTIPLIER> 1
<CURRENCY> U.S. DOLLARS

<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-2000
<PERIOD-START>                             JAN-01-2000
<PERIOD-END>                               SEP-30-2000
<EXCHANGE-RATE>                                      1
<CASH>                                      80,412,200
<SECURITIES>                                         0
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                            82,204,075
<PP&E>                                       2,107,988
<DEPRECIATION>                                 687,741
<TOTAL-ASSETS>                              84,314,147
<CURRENT-LIABILITIES>                        2,207,012
<BONDS>                                              0
                                0
                                          0
<COMMON>                                        13,381
<OTHER-SE>                                  82,093,754
<TOTAL-LIABILITY-AND-EQUITY>                84,314,147
<SALES>                                              0
<TOTAL-REVENUES>                                     0
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                             9,520,091
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                               8,889
<INCOME-PRETAX>                            (6,561,850)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                        (6,561,850)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                               (6,561,850)
<EPS-BASIC>                                     (0.65)
<EPS-DILUTED>                                   (0.65)


</TABLE>



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