CURAGEN CORP
424B3, 2000-12-19
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>

                                           Filed Pursuant to Rule 424(b)(3)
                                                 REGISTRATION NO. 333-32756

           PROSPECTUS SUPPLEMENT NO. 4 DATED DECEMBER 19, 2000 TO THE
                       PROSPECTUS DATED JUNE 30, 2000 OF
                              CURAGEN CORPORATION

     This Prospectus Supplement No. 4 amends the information in the table under
the caption "Selling Holders" in the Prospectus dated June 30, 2000, as
supplemented on August 7, 2000, September 15, 2000 and October 25, 2000, by
deleting the information contained in the table regarding the Selling
Securityholders and substituting therefor the following table:

<TABLE>
<CAPTION>
Name of Security Holder     Principal Amount of     Common Stock Owned     Common Stock Offered     Common Stock Owned
                          Debentures Beneficially                                                   After Completion of
                           Owned and Offered (in                                                       The Offering
                                thousands)

<S>                       <C>                      <C>                   <C>                      <C>
AIG SoundShore Holdings,          $ 8,725                 136,696                  136,696                    0
 LTD

AIG SoundShore                    $ 2,500                  39,168                   39,168                    0
 Opportunity Holdings
 Fund LTD

AIG SoundShore Strategic          $ 1,106                  17,328                   17,328                    0
 Holding
 Fund LTD

Alta Partners Holdings LDC        $ 4,000                  62,669                   62,669                    0

Argent Classic                    $ 5,875                  92,045                   92,045                    0
 Convertible Arbitrage
 Fund (Bermuda) L.P.

Argent Convertible                $ 1,000                  15,667                   15,667                    0
 Arbitrage Fund Ltd.

BNP Arbitrage SNC                 $ 3,750                  58,752                   58,752                    0

BNP Cooper Neff                   $   250                   3,917                    3,917                    0
 Convertible Strategies
 Fund, L.P.

CFFX, L.L.C.                      $ 1,000                  15,667                   15,667                    0

Chartwell Investment              $ 1,000                  15,667                   15,667                    0
 Partners

CLSP, L.P.                             --                 534,079                  226,913              307,166

CLSP-SBS I, L.P.                       --                  81,034                   81,034                    0

CSLP-SBS II, L.P.                      --                  30,397                   30,397                    0

CLSP II, L.P.                          --                  36,656                   36,656                    0

Credit Research and               $   680                  10,654                   10,654                    0
 Trading LLC

Credit Suisse First               $ 2,200                  34,468                   34,468                    0
 Boston Corporation

Deephaven Domestic                $ 3,500                  54,835                   54,835                    0
 Convertible Trading LTD

Depository Trust Company          $29,408                 460,742                                             0

Deutsche Bank                     $11,000                 172,339                  172,339                    0
 Securities, Inc.

Donaldson, Lufkin and             $ 4,125                  64,627                   64,627                    0
 Jenrette Securities
 Corporation
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
Name of Security Holder     Principal Amount of     Common Stock Owned     Common Stock Offered     Common Stock Owned
                          Debentures Beneficially                                                   After Completion of
                           Owned and Offered (in                                                       The Offering
                                thousands)

<S>                       <C>                      <C>                   <C>                      <C>
Family Services Life              $   300                   4,700                      4,700                  0
 Insurance Co.

Fidelity Financial Trust          $ 6,000                  94,003                     94,003                  0

Fir Tree Value Fund LP            $ 7,041                 110,309                    110,309                  0

Fir Tree Institutional            $ 2,611                  40,902                     40,902                  0
 Value Fund LP

Fir Tree Value Partners           $   725                  11,352                     11,352                  0
 LDC II

Fir Tree Value Fund LP #2         $ 1,000                  15,667                     15,667                  0

Guardian Life                     $ 6,500                 101,837                    101,837                  0
 Insurance Co.

Guardian Pension Trust            $   200                   3,133                      3,133                  0

Helix Convertible                 $ 1,620                  25,381                     25,381                  0
 Opportunities Fund Ltd

Helix Convertible                 $ 2,875                  45,043                     45,043                  0
 Opportunities, L.P.

JMG Capital Partners LP           $ 4,688                  73,448                     73,448                  0

JMG Convertible                   $   500                   7,834                      7,834                  0
 Investments LP

JMG Triton Offshore Fund          $ 8,207                 128,581                    128,581                  0
 LTD

J.P. Morgan Securities, Inc.      $ 3,000                  47,002                     47,002                  0

KBC Financial Products            $   200                   3,133                      3,133                  0

Lyxor Master Fund                 $ 2,750                  43,085                     43,085                  0

McMahan Securities Co. L.P.       $   250                   3,917                      3,917                  0

Merrill Lynch Convertible         $   250                   3,917                      3,917                  0
 Fund, Inc.

Michael Angelo, LP                $ 3,250                  50,918                     50,918                  0

Morgan Stanley & Co.              $ 2,500                  39,168                     39,168                  0

Paloma Securities LLC             $ 1,000                  15,667                     15,667                  0

</TABLE>
<PAGE>

<TABLE>
<CAPTION>
Name of Security Holder     Principal Amount of     Common Stock Owned     Common Stock Offered     Common Stock Owned
                          Debentures Beneficially                                                   After Completion of
                           Owned and Offered (in                                                       The Offering
                                thousands)

<S>                       <C>                      <C>                   <C>                      <C>

Pequot Partners                        --               3,638,000                  1,500,000          2,138,000
 Fund, LP

Pequot International                   --               1,500,000                  1,500,000                  0
 Fund, Inc.

Quantum Industrial                     --               3,626,517                    281,250          3,345,267
 Partners LDC

Quantum Partners LDC                   --                 281,250                    281,250                  0

R2 Investments LDC                $ 6,500                 101,837                    101,837                  0

Sagamore Hill Hub                 $   250                   3,917                      3,917                  0
 Fund Ltd.

St. Thomas Trading, Ltd.          $    50                     783                        783                  0

The Common Fund f/a/o             $   505                   7,912                      7,912                  0
 Absolute Return Fund

Tribeca Investments LLC           $29,825                 467,275                    467,275                  0

Value Line Convertible            $   500                   7,834                      7,834                  0
 Fund, Inc.

Warburg Dillon                    $    30                     470                        470                  0
 Read LLC

</TABLE>

  This Prospectus Supplement No. 4 should be read in conjunction with the
Prospectus dated June 30, 2000. In addition, the selling holders identified
above may have sold, transferred or otherwise disposed of all or a portion of
their debentures since the date on which they provided the information about
their debentures in transactions exempt from the registration requirements of
the Securities Act.


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