UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: March 31, 1999
Check here if Amendment [ ]; Amendment Number: _________
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisers Inc.
Address: 767 Third Avenue, 6th Floor
New York, NY 10010
Form 13F File Number: 28-6776
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: President
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY April 14, 1999
[Signature] [City, State] [Date]
Report Type (Check only one.):
[X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting
manager are reported in this report.)
<PAGE>
[ ] 13F NOTICE. (Check here if no holdings reported are in this report,
and all holdings are reported by other reporting manager(s).)
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for
this reporting manager are reported in this report and a portion are
reported by other reporting manager(s).)
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Form 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 51
Form 13F Information Table Value Total: $321,056
(thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings
and list entries.]
No. Form 13F File Number Name
2 28-6774 OrbiMed Advisors LLC
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Form 13F INFORMATION TABLE
Quarter Ended March 31, 1999
Manager Key: (1) OrbiMed Advisers Inc.
(2) OrbiMed Advisors LLC
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Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
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Investment Discretion Voting Authority (Shares)
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Name of Issuer Title of Class CUSIP Number Market Value SHRS Sole Shared Shared Other Sole Shared None
(x $1,000) Defined Other Managers
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<S> <C> <C> <C> <C> <C> <C> <C>
Abgenix, Inc COM 00339B107 4,839 319,923 X 1 319,923
Abgenix, Inc COM 00339B107 4,305 284,615 X 2 284,615
Agouron COM 008488108 1,980 35,000 X 1 35,000
Pharmaceuticals Inc.
Agouron Pharmaceuticals COM 008488108 849 15,000 X 2 15,000
Inc.
Alexion Pharmaceuticals, COM 015351109 2,279 270,000 X 1 270,000
Inc.
Alexion Pharmaceuticals, COM 015351109 4,054 480,500 X 2 480,500
Inc.
Aquila COM 03839f107 1,079 523,000 X 2 523,000
Biopharmaceuticals
Aronex COM 42666206 1,875 600,000 X 2 600,000
Aviron COM 053762100 2,531 125,000 X 1 125,000
Aviron COM 053762100 6,397 315,880 X 2 315,880
Bio-Technology General COM 90578105 2,388 400,000 X 1 400,000
Bio-Technology General COM 90578105 4,697 6,684,906 X 2 6,684,906
BioChem Pharma COM 09058T108 4,497 211,000 X 1 211,000
BioChem Pharma COM 09058T108 9,955 467,110 X 2 467,110
CV Therapeutics COM 126667104 2,291 469,940 X 2 469,940
Centocor Inc. COM 152342101 8,325 225,000 X 1 225,000
Centocor Inc. COM 152342101 16,480 445,410 X 2 445,410
Depomed Inc. COM 249908104 3,629 360,100 X 2 360,100
Eli Lilly & Company COM 532457108 6,800 80,000 X 1 80,000
Eli Lilly & Company COM 532457108 12,583 148,030 X 2 148,030
Enzon Inc. COM 293904108 2,913 197,520 X 2 197,520
Genentech COM 368710307 6,647 75,000 X 1 75,000
Genentech COM 368710307 5,993 67,620 X 2 67,620
Genzyme Corp. General COM 372917104 7,566 150,000 X 1 150,000
Division
Genzyme Corp. General COM 372917104 15,827 313,800 X 2 313,800
Division
</TABLE>
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<TABLE>
<CAPTION>
<S> <C> <C> <C> <C> <C> <C> <C>
Gilead Sciences Inc. COM 375558103 6,984 153,500 X 1 153,500
Gilead Sciences Inc. COM 375558103 11,021 242,210 X 2 242,210
Hyseq Inc. COM 449163302 1,111 370,190 X 2 370,190
IDEC Pharmaceuticals COM 449370105 11,246 218,900 X 2 218,900
Incyte Pharmaceuticals COM 45337c102 4,013 200,000 X 1 200,000
Inc.
Incyte Pharmaceuticals COM 45337c102 4,863 242,410 X 2 242,410
Inc.
Merck, Inc. COM 589331107 8,013 100,000 X 1 100,000
Merck, Inc. COM 589331107 16,546 206,500 X 2 206,500
Monsanto COM 6116621078 9,188 200,000 X 1 200,000
Monsanto COM 6116621078 18,866 410,690 X 2 410,690
Pharmacia and Upjohn COM 716941109 7,485 120,000 X 1 120,000
Inc.
Pharmacia and Upjohn COM 716941109 19,147 306,970 X 2 306,970
Inc.
Pharmacopeia Inc. COM 71713B104 1,958 270,000 X 1 270,000
Pharmacopeia Inc. COM 71713B104 2,060 284,100 X 2 284,100
Premier Research COM 740568100 2,144 235,000 X 1 235,000
Worldwide
SangStat Medical Corp. COM 801003104 3,218 260,000 X 1 260,000
SangStat Medical Corp. COM 801003104 5,383 435,010 X 2 435,010
Sugen COM 865041107 1,727 90,000 X 2 90,000
Titan Pharmaceutical COM 888314101 1,969 525,000 X 2 525,000
Triangle Pharmaceutical COM 89589H1041 2,138 200,000 X 1 200,000
Triangle Pharmaceutical COM 89589H1041 1,454 136,000 X 2 136,000
Vertex Pharmaceuticals COM 92532F100 5,681 225,000 X 1 225,000
Inc.
Vertex Pharmaceuticals COM 92532F100 9,389 371,860 X 2 371,860
Inc.
Warner-Lambert Co. COM 934488107 7,288 110,000 X 1 110,000
Warner-Lambert Co. COM 934488107 16,594 250,480 X 2 250,480
Zonagen COM 98975L108 791 36,800 X 2 36,800
Total 321,056 19,464,974 19,464,974
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