Quarter Ended: June 30, 2000
Manager Key: (1) Orbimed Advisers, Inc. (Eaton Vance Worldwide Health Sciences
Fund, Paine Webber Eucalyptus LLC and LTD)
(2) Orbimed Advisors LLC (Other Funds)
<TABLE>
<CAPTION>
Investment Discretion Voting Authority
Title of CUSIP Market Shared Shared Other (Shares)
Name of Issuer Class Number Value SHRS Sole Defined Other Managers Sole Shared None
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<S> <C> <C> <C> <C> <C> <C> <C>
Abgenix, Inc COM 00339B107 28,190,925 235,200 X 1 235,200
Abgenix, Inc COM 00339B107 22,965,056 191,600 X 2 191,600
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Alexion Pharmaceuticals, Inc. COM 015351109 15,015,000 210,000 X 1 210,000
Alexion Pharmaceuticals, Inc. COM 015351109 15,050,750 210,500 X 2 210,500
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Alza Corp. COM 22615108 33,583,000 568,000 X 1 568,000
Alza Corp. COM 22615108 9,105,250 154,000 X 2 154,000
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American Home Products COM 26609107 33,135,000 564,000 X 1 564,000
American Home Products COM 26609107 33,135,000 564,000 X 2 564,000
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Amgen Inc. COM 31162100 6,814,250 97,000 X 1 97,000
Amgen Inc. COM 31162100 16,649,250 237,000 X 2 237,000
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Arqule Inc. COM 04269E107 3,450,687 178,100 X 1 178,100
Arqule Inc. COM 04269E107 3,136,812 161,900 X 2 161,900
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Aviron COM 053762100 7,718,750 250,000 X 1 250,000
Aviron COM 053762100 4,631,250 150,000 X 2 150,000
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Bio-Technology General COM 090578105 13,022,656 987,500 X 1 987,500
Bio-Technology General COM 090578105 12,561,094 952,500 X 2 952,500
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Biotransplant Inc. COM 09066Y107 1,828,750 190,000 X 2 190,000
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Caliper Technologies COM 130876105 23,630,200 513,700 X 1 513,700
Caliper Technologies COM 130876105 23,435,083 509,458 X 2 509,458
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Cell Genesys Inc. COM 150921104 3,869,600 138,200 X 1 138,200
Cell Genesys Inc. COM 150921104 3,080,000 110,000 X 2 110,000
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Cell Therapeutics COM 150934107 9,340,625 305,000 X 2 305,000
Cell Therapeutics COM 150934107 17,915,319 584,990 X 2 584,990
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Chiron Corp. COM 170040109 37,919,250 798,300 X 1 798,300
Chiron Corp. COM 170040109 21,755,000 458,000 X 2 458,000
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COR Therapeutics Inc. COM 217753102 7,268,625 85,200 X 1 85,200
COR Therapeutics Inc. COM 217753102 6,142,500 72,000 X 2 72,000
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Discovery Laboratories Inc. COM 254668106 15,804,220 3,512,049 X 2 3,512,049
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Eli Lilly & Company COM 532457108 40,596,000 408,000 X 1 408,000
Eli Lilly & Company COM 532457108 39,800,000 400,000 X 2 400,000
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Enzon Inc. COM 293904108 14,556,250 342,500 X 1 342,500
Enzon Inc. COM 293904108 5,950,000 140,000 X 2 140,000
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Forest Laboratories - CL A COM 345838106 23,735,000 235,000 X 1 235,000
Forest Laboratories - CL A COM 345838106 26,058,000 258,000 X 2 258,000
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Geltex Pharmaceuticals Inc. COM 368538104 17,488,369 855,700 X 1 855,700
Geltex Pharmaceuticals Inc. COM 368538104 18,005,437 881,000 X 2 881,000
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Genta Inc. COM 37245M207 1,424,085 219,090 X 2 219,090
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Genzyme Corp. General Division COM 372917104 27,739,481 466,700 X 1 466,700
Genzyme Corp. General Division COM 372917104 27,638,437 465,000 X 2 465,000
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Gilead Sciences Inc. COM 375558103 22,980,487 323,100 X 1 323,100
Gilead Sciences Inc. COM 375558103 19,843,875 279,000 X 2 279,000
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Insmed Incorporated COM 457669208 1,374,292 422,859 X 1 422,859
Insmed Incorporated COM 457669208 2,340,006 720,002 X 2 720,002
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IntraBiotics Pharma COM 46116T100 4,447,926 166,667 X 1 166,667
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LJL Biosystems Inc. COM 501873103 9,869,624 509,400 X 1 509,400
LJL Biosystems Inc. COM 501873103 3,100,000 160,000 X 2 160,000
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NPS Pharmaceuticals Inc. COM 62936P103 5,376,750 201,000 X 1 201,000
NPS Pharmaceuticals Inc. COM 62936P103 6,069,575 226,900 X 2 226,900
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Orapharma Inc. COM 68554E106 6,000,000 600,000 X 1 600,000
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Orchid Biosciences COM 68571P100 42,002,284 1,106,233 X 1 1,106,233
Orchid Biosciences COM 68571P100 58,793,002 1,554,219 X 2 1,554,219
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Orphan Medical, Inc. COM 687303107 6,635,937 685,000 X 1 685,000
Orphan Medical, Inc. COM 687303107 5,618,750 580,000 X 2 580,000
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PathoGenesis Corp. COM 70321E104 13,582,400 522,400 X 2 522,400
PathoGenesis Corp. COM 70321E104 13,837,200 532,200 X 2 532,200
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PE Corp - Celera COM 69332S201 7,863,350 84,100 X 2 84,100
PE Corp - Celera COM 69332S201 6,685,250 71,500 X 2 71,500
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Pfizer Inc. COM 717081103 54,912,000 1,144,000 X 2 1,144,000
Pfizer Inc. COM 717081103 61,380,000 1,278,750 X 2 1,278,750
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Pharmacia Corp. COM 71713U102 32,759,537 633,800 X 1 633,800
Pharmacia Corp. COM 71713U102 38,843,156 751,500 X 2 751,500
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</TABLE>
<PAGE>
<TABLE>
<CAPTION>
Investment Discretion Voting Authority
Title of CUSIP Market Shared Shared Other (Shares)
Name of Issuer Class Number Value SHRS Sole Defined Other Managers Sole Shared None
------------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C>
Pharmacopeia Inc. COM 71713B104 23,094,750 498,000 X 1 498,000
Pharmacopeia Inc. COM 71713B104 12,266,187 264,500 X 2 264,500
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Praecis Pharmaceutical, Inc. COM 739421105 12,401,587 444,900 X 1 444,900
Praecis Pharmaceutical, Inc. COM 739421105 19,592,850 702,882 X 2 702,882
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Repligen Corp. COM 759916109 1,111,781 177,000 X 1 177,000
Repligen Corp. COM 759916109 1,174,594 187,000 X 2 187,000
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SangStat Medical Corp. COM 801003104 14,524,125 503,000 X 1 503,000
SangStat Medical Corp. COM 801003104 12,754,087 441,700 X 2 441,700
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Tularik Inc. COM 899165104 22,154,500 751,000 X 1 751,000
Tularik Inc. COM 899165104 19,765,000 670,000 X 2 670,000
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Vertex Pharmaceuticals Inc. COM 92532F100 13,698,750 130,000 X 1 130,000
Vertex Pharmaceuticals Inc. COM 92532F100 4,215,000 40,000 X 2 40,000
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Watson Pharmaceutical Inc. COM 942683103 30,530,000 568,000 X 1 568,000
Watson Pharmaceutical Inc. COM 942683103 7,686,250 143,000 X 2 143,000
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Total 1,292,429,823 35,732,799 35,732,799
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</TABLE>
