UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: March 31, 2000
Check here if Amendment [ ]; Amendment Number:
------------
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisers Inc.
Address: 767 Third Avenue, 6th Floor
New York, NY 10010
Form 13F File Number: 28-6776
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: President
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY May 12, 2000
[Signature] [City, State] [Date]
Report Type (Check only one.):
[X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager
are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report, and all
holdings are reported by other reporting manager(s).)
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this
reporting manager are reported in this report and a portion are reported by
other reporting manager(s).)
<PAGE>
Form 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 72
Form 13F Information Table Value Total: $868,700,213
(thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings
and list entries.]
No. Form 13F File Number Name
2 28-6774 OrbiMed Advisors LLC
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Form 13F INFORMATION TABLE
Quarter Ended March 31, 2000
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<CAPTION>
Manager Key: (1) Orbimed Advisers, Inc. (Eaton Vance Worldwide Health Sciences Fund, Paine Webber Eucalyptus LLC and LTD)
(2) Orbimed Advisors LLC (Other Funds)
Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
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Investment Discretion Voting Authority
(Shares)
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Name of Issuer Title of CUSIP Number Market Value SHRS Sole Shared Shared Other Sole Shared None
Class Defined Other Managers
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<S> <C> <C> <C> <C> <C> <C> <C>
Abgenix, Inc COM 00339B107 16,022,500 116,000 X 1 116,000
Abgenix, Inc COM 00339B107 13,577,687 48,500 X 2 48,500
Aclara Biosciences COM 00461P106 2,169,062 55,000 X 1 55,000
Aclara Biosciences COM 00461P106 1,912,719 48,500 X 2 48,500
Affymetrix Inc. COM 00826T108 17,025,781 114,700 X 1 114,700
Affymetrix Inc. COM 00826T108 4,527,344 30,500 X 2 30,500
Alexion Pharmaceuticals, COM 015351109 14,647,500 210,000 X 1 210,000
Inc.
Alexion Pharmaceuticals, COM 015351109 14,682,375 210,500 X 2 210,500
Inc.
Alza Corp. COM 22615108 24,453,187 651,000 X 1 651,000
Alza Corp. COM 22615108 5,784,625 154,000 X 2 154,000
American Home Products COM 26609107 32,948,750 613,000 X 1 613,000
American Home Products COM 26609107 24,940,000 464,000 X 2 464,000
Aviron COM 053762100 6,953,125 250,000 X 1 250,000
Aviron COM 053762100 4,171,875 150,000 X 2 150,000
Bio-Technology General COM 090578105 15,306,250 987,500 X 1 987,500
Bio-Technology General COM 090578105 14,763,750 952,500 X 2 952,500
Biotransplant Inc. COM 09066Y107 2,030,625 190,000 X 2 190,000
Caliper Technologies COM 130876105 3,526,150 43,600 X 1 43,600
Caliper Technologies COM 130876105 33,074,505 408,958 X 2 408,958
Cell Genesys Inc. COM 150921104 1,577,125 74,000 X 1 74,000
Cell Genesys Inc. COM 150921104 1,150,875 54,000 X 2 54,000
Cell Therapeutics COM 150934107 3,925,781 167,500 X 2 167,500
Cell Therapeutics COM 150934107 10,838,156 462,428 X 2 462,428
Chiron Corp. COM 170040109 22,777,912 456,700 X 1 456,700
Chiron Corp. COM 170040109 13,366,500 268,000 X 2 268,000
COR Therapeutics Inc. COM 217753102 4,251,961 64,500 X 1 64,500
COR Therapeutics Inc. COM 217753102 3,032,406 46,000 X 2 46,000
Discovery Laboratories COM 254668106 22,828,318 3,512,049 X 2 3,512,049
Inc.
Eli Lilly & Company COM 532457108 19,225,875 307,000 X 1 307,000
Eli Lilly & Company COM 532457108 21,668,250 346,000 X 2 346,000
Enzon Inc. COM 293904108 10,096,481 267,900 X 1 267,900
Enzon Inc. COM 293904108 5,276,249 140,000 X 2 140,000
Forest Laboratories - COM 345838106 23,322,000 276,000 X 1 276,000
CL A
Forest Laboratories - COM 345838106 24,167,000 286,000 X 2 286,000
CL A
Geltex Pharmaceuticals COM 368538104 10,912,625 651,500 X 1 651,500
Inc.
Geltex Pharmaceuticals COM 368538104 14,564,125 869,500 X 2 869,500
Inc.
Genta Inc. COM 37245M207 1,937,500 200,000 X 2 200,000
Genzyme Corp. General COM 372917104 18,380,837 366,700 X 1 366,700
Division
Genzyme Corp. General COM 372917104 17,914,675 357,400 X 2 357,400
Division
Gilead Sciences Inc. COM 375558103 19,329,375 305,000 X 1 305,000
Gilead Sciences Inc. COM 375558103 23,924,062 377,500 X 2 377,500
IntraBiotics Pharma COM 46116T100 6,100,005 406,667 X 1 406,667
IntraBiotics Pharma COM 46116T100 1,725,000 115,000 X 2 115,000
LJL Biosystems Inc. COM 501873103 6,652,125 540,000 X 1 540,000
LJL Biosystems Inc. COM 501873103 2,555,000 140,000 X 2 140,000
Monsanto COM 611662107 24,745,000 490,000 X 1 490,000
Monsanto COM 611662107 26,815,500 531,000 X 2 531,000
NPS Pharmaceuticals Inc. COM 62936P103 3,027,562 201,000 X 1 201,000
NPS Pharmaceuticals Inc. COM 62936P103 3,342,368 221,900 X 2 221,900
Orapharma Inc. COM 68554E106 2,719,500 147,000 X 1 147,000
Orphan Medical, Inc. COM 687303107 7,449,375 685,000 X 1 685,000
Orphan Medical, Inc. COM 687303107 6,307,500 580,000 X 2 580,000
PathoGenesis Corp. COM 70321E104 8,149,050 358,200 X 2 358,200
PathoGenesis Corp. COM 70321E104 10,278,450 451,800 X 2 451,800
PE Corp - Celera COM 693325201 3,961,375 43,000 X 2 43,000
PE Corp - Celera COM 693325201 3,592,875 39,000 X 2 39,000
Pharmacia and Upjohn Inc. COM 716941109 7,140,000 120,000 X 1 120,000
Pharmacia and Upjohn Inc. COM 716941109 14,875,000 250,000 X 2 250,000
Pharmacopeia Inc. COM 71713B104 6,370,000 130,000 X 1 130,000
Pharmacopeia Inc. COM 71713B104 5,488,000 112,000 X 2 112,000
Repligen Corp. COM 759916109 1,703,625 177,000 X 1 177,000
Repligen Corp. COM 759916109 1,799,875 187,000 X 2 187,000
SangStat Medical Corp. COM 801003104 10,410,500 376,000 X 1 376,000
SangStat Medical Corp. COM 801003104 12,229,569 441,700 X 2 441,700
Tularik Inc. COM 899165104 11,022,375 357,000 X 1 357,000
Tularik Inc. COM 899165104 7,502,625 243,000 X 2 243,000
Vertex Pharmaceutical COM 92532F100 16,641,844 355,500 X 1 355,500
Inc.
Vertex Pharmaceutical COM 92532F100 17,788,750 380,000 X 2 380,000
Inc.
Warner-Lambert Co. COM 934488107 30,771,562 315,000 X 1 315,000
Warner-Lambert Co. COM 934488107 51,481,312 527,000 X 2 527,000
Watson Pharmaceutical COM 942683103 4,564,062 115,000 X 1 115,000
Inc.
Watson Pharmaceutical COM 942683103 4,504,531 113,500 X 2 113,500
Inc.
Total 868,700,213 24,703,202 24,703,202
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