DELTAGEN INC
S-1/A, EX-1.1, 2000-07-24
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                   EXHIBIT 1.1

                                 Deltagen, Inc.

                               7,000,000 Shares (1)
                                  Common Stock
                               ($0.001 par value)

                             Underwriting Agreement

                                                              New York, New York
                                                                          , 2000

Salomon Smith Barney Inc.
Robertson Stephens Inc.
U.S. Bancorp Piper Jaffray Inc.
Donaldson Lufkin & Jenrette Securities Corporation
As Representatives of the several Underwriters,
c/o Salomon Smith Barney Inc.
388 Greenwich Street
New York, New York 10013

Ladies and Gentlemen:

     Deltagen, Inc., a corporation organized under the laws of Delaware (the
"Company"), proposes to sell to the several underwriters named in Schedule I
hereto (the "Underwriters"), for whom you (the "Representatives") are acting as
representatives, 7,000,000 shares of Common Stock, $0.001 par value ("Common
Stock") of the Company (said shares to be issued and sold by the Company being
hereinafter called the "Underwritten Securities"). The Company also proposes to
grant to the Underwriters an option to purchase up to 1,050,000 additional
shares of Common Stock to cover over-allotments (the "Option Securities"; the
Option Securities, together with the Underwritten Securities, being hereinafter
called the "Securities"). To the extent there are no additional Underwriters
listed on Schedule I other than you, the term Representatives as used herein
shall mean you, as Underwriters, and the terms Representatives and Underwriters
shall mean either the singular or plural as the context requires. Certain terms
used herein are defined in Section 17 hereof.

     As part of the offering contemplated by this Agreement, Salomon Smith
Barney Inc. has agreed to reserve out of the Securities set forth opposite its
name on the Schedule II to this Agreement up to 700,000 shares, for sale to the
Company's directors, officers and employees as well as its clients, vendors and
other parties associated with the

--------
    (1) Plus an option to purchase from the Company, up to 1,050,000 additional
Securities to cover over-allotments.


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                                                                               2

Company (the "Participants"), as set forth in the Prospectus under the heading
"Underwriting" (the "Directed Share Program"). The Securities to be sold by
Salomon Smith Barney Inc. pursuant to the Directed Share Program (the "Directed
Shares") will be sold by Salomon Smith Barney Inc. pursuant to this Agreement at
the public offering price. Any Directed Shares not orally confirmed for purchase
by any Participants by the end of the business day on which this Agreement is
executed will be offered to the public by Salomon Smith Barney Inc. as set forth
in the Prospectus.

     1.   REPRESENTATIONS AND WARRANTIES. The Company represents and warrants
to, and agrees with, each Underwriter as set forth below in this Section 1.

          (a)  The Company has prepared and filed with the Commission a
     registration statement (file number 333-34668) on Form S-1, including a
     related preliminary prospectus, for registration under the Act of the
     offering and sale of the Securities. The Company may have filed one or more
     amendments thereto, including a related preliminary prospectus, each of
     which has previously been furnished to you. The Company will next file with
     the Commission either (1) prior to the Effective Date of such registration
     statement, a further amendment to such registration statement (including
     the form of final prospectus) or (2) after the Effective Date of such
     registration statement, a final prospectus in accordance with Rules 430A
     and 424(b). In the case of clause (2), the Company has included in such
     registration statement, as amended at the Effective Date, all information
     (other than Rule 430A Information) required by the Act and the rules
     thereunder to be included in such registration statement and the
     Prospectus. As filed, such amendment and form of final prospectus, or such
     final prospectus, shall contain all Rule 430A Information, together with
     all other such required information, and, except to the extent the
     Representatives shall agree in writing to a modification, shall be in all
     substantive respects in the form furnished to you prior to the Execution
     Time or, to the extent not completed at the Execution Time, shall contain
     only such specific additional information and other changes (beyond that
     contained in the latest Preliminary Prospectus) as the Company has advised
     you, prior to the Execution Time, will be included or made therein.

          (b)  On the Effective Date, the Registration Statement did or will,
     and when the Prospectus is first filed (if required) in accordance with
     Rule 424(b) and on the Closing Date (as defined herein) and on any date on
     which Option Securities are purchased, if such date is not the Closing Date
     (a "Settlement Date"), the Prospectus (and any supplements thereto) will,
     comply in all material respects with the applicable requirements of the Act
     and the rules thereunder; on the Effective Date and at the Execution Time,
     the Registration Statement did not or will not contain any untrue statement
     of a material fact or omit to state any material fact required to be stated
     therein or necessary in order to make the statements therein not
     misleading; and, on the Effective Date, the Prospectus, if not filed
     pursuant to Rule 424(b), will not, and on the date of any filing pursuant
     to Rule 424(b) and on the Closing Date and any Settlement Date, the
     Prospectus (together with any supplement thereto) will not, include any
     untrue statement of a material fact or omit to state a material fact
     necessary in order to make the statements therein, in the light of the
     circumstances under which they were made, not misleading; PROVIDED,
     HOWEVER, that the Company


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                                                                               3

     makes no representations or warranties as to the information contained in
     or omitted from the Registration Statement, or the Prospectus (or any
     supplement thereto) in reliance upon and in conformity with information
     furnished in writing to the Company by or on behalf of any Underwriter
     through the Representatives specifically for inclusion in the Registration
     Statement or the Prospectus (or any supplement thereto).

          (c)  The Company has been duly incorporated and is validly existing as
     a corporation in good standing under the laws of the State of Delaware with
     full corporate power and authority to own or lease, as the case may be, and
     to operate its properties and conduct its business as described in the
     Prospectus, and is duly qualified to do business as a foreign corporation
     and is in good standing under the laws of each jurisdiction which requires
     such qualification.

          (d)  The Company's authorized equity capitalization is as set forth in
     the Prospectus; the capital stock of the Company conforms in all material
     respects to the description thereof contained in the Prospectus; the
     outstanding shares of Common Stock have been duly and validly authorized
     and issued and are fully paid and non assessable; the Securities have been
     duly and validly authorized, and, when issued and delivered to and paid for
     by the Underwriters pursuant to this Agreement, will be fully paid and
     nonassessable; the Securities are duly listed, and admitted and authorized
     for trading, subject to official notice of issuance and evidence of
     satisfactory distribution, on the Nasdaq National Market; the certificates
     for the Securities are in valid and sufficient form; the holders of
     outstanding shares of capital stock of the Company are not entitled to
     preemptive or other rights to subscribe for the Securities; and, except as
     set forth in the Prospectus, no options, warrants or other rights to
     purchase, agreements or other obligations to issue, or rights to convert
     any obligations into or exchange any securities for, shares of capital
     stock of or ownership interests in the Company are outstanding.

          (e)  There is no franchise, contract or other document of a character
     required to be described in the Registration Statement or Prospectus, or to
     be filed as an exhibit thereto, which is not described or filed as
     required.

          (f)  This Agreement has been duly authorized, executed and delivered
     by the Company and constitutes a valid and binding obligation of the
     Company enforceable in accordance with its terms.

          (g)  The Company is not and, after giving effect to the offering and
     sale of the Securities and the application of the proceeds thereof as
     described in the Prospectus, will not be an "investment company" as defined
     in the Investment Company Act of 1940, as amended.


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                                                                               4

          (h)  No consent, approval, authorization, filing with or order of any
     court or governmental agency or body is required in connection with the
     transactions contemplated herein, except such as have been obtained under
     the Act and such as may be required under the blue sky laws of any
     jurisdiction in connection with the purchase and distribution of the
     Securities by the Underwriters in the manner contemplated herein and in the
     Prospectus.

          (i)  Neither the issue and sale of the Securities nor the consummation
     of any other of the transactions herein contemplated nor the fulfillment of
     the terms hereof will conflict with, or result in a breach or violation or
     imposition of any lien, charge or encumbrance upon any property or assets
     of the Company pursuant to, (i) the Amended and Restated Certificate of
     Incorporation, as amended or by-laws of the Company, (ii) the terms of any
     indenture, contract, lease, mortgage, deed of trust, note agreement, loan
     agreement or other agreement, obligation, condition, covenant or instrument
     to which the Company is a party or bound or to which its or their property
     is subject, or (iii) any statute, law, rule, regulation, judgment, order or
     decree applicable to the Company of any court, regulatory body,
     administrative agency, governmental body, arbitrator or other authority
     having jurisdiction over the Company or any of its properties, which
     violation or default would, in the case of clauses (ii) and (iii) above,
     either individually or in the aggregate, have a material adverse effect on
     the condition (financial or otherwise), prospects, earnings, business or
     properties of the Company, whether or not arising from transactions in the
     ordinary course of business.

          (j)  No holders of securities of the Company have rights to the
     registration of such securities under the Registration Statement that have
     not been waived.

          (k)  The historical financial statements and schedules of the Company
     included in the Prospectus and the Registration Statement present fairly in
     all material respects the financial condition, results of operations and
     cash flows of the Company as of the dates and for the periods indicated,
     comply as to form with the applicable accounting requirements of the Act
     and have been prepared in conformity with generally accepted accounting
     principles applied on a consistent basis through out the periods involved
     (except as otherwise noted therein). The selected financial data set forth
     under the caption "Selected Financial Data" in the Prospectus and
     Registration Statement fairly present, on the basis stated in the
     Prospectus and the Registration Statement, the information included
     therein.

          (l)  No action, suit or proceeding by or before any court or
     governmental agency, authority or body or any arbitrator involving the
     Company or its property is pending or, to the best knowledge of the
     Company, threatened that (i) could reason-


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                                                                               5

     ably be expected to have a material adverse effect on the performance of
     this Agreement or the consummation of any of the transactions contemplated
     hereby or (ii) could reasonably be expected to have a material adverse
     effect on the condition (financial or otherwise), prospects, earnings,
     business or properties of the Company whether or not arising from
     transactions in the ordinary course of business, except as set forth in or
     contemplated in the Prospectus (exclusive of any supplement thereto).

          (m)  The Company owns or leases all such properties as are necessary
     to the conduct of its operations as presently conducted.

          (n)  The Company is not in violation or default of (i) any provision
     of its Amended and Restated Certificate of Incorporation, as amended or
     bylaws, (ii) the terms of any indenture, contract, lease, mortgage, deed of
     trust, note agreement, loan agreement or other agreement, obligation,
     condition, covenant or instrument to which it is a party or bound or to
     which its property is subject, or (iii) any statute, law, rule, regulation,
     judgment, order or decree of any court, regulatory body, administrative
     agency, governmental body, arbitrator or other authority having
     jurisdiction over the Company or any of its properties, as applicable,
     which violation or default would, in the case of clauses (ii) and (iii)
     above, either individually or in the aggregate, have a material adverse
     effect on the condition (financial or otherwise), prospects, earnings,
     business or properties of the Company, whether or not arising from
     transactions in the ordinary course of business.

          (o)  PricewaterhouseCoopers LLP, who have certified certain financial
     statements of the Company and delivered their report with respect to the
     audited consolidated financial statements and schedules included in the
     Prospectus, are independent public accountants with respect to the Company
     within the meaning of the Act and the applicable published rules and
     regulations thereunder.

          (p)  There are no transfer taxes or other similar fees or charges
     under Federal law or the laws of any state, or any political subdivision
     thereof, required to be paid in connection with the execution and delivery
     of this Agreement or the issuance by the Company or sale by the Company of
     the Securities.

          (q)  The Company has filed all foreign, federal, state and local tax
     returns that are required to be filed or has requested extensions thereof
     (except in any case in which the failure so to file would not have a
     material adverse effect on the condition (financial or otherwise),
     prospects, earnings, business or properties of the Company whether or not
     arising from transactions in the ordinary course of business, except as set
     forth in or contemplated in the Prospectus (exclusive of any supplement
     thereto)) and has paid all taxes required to be paid by it and any other
     assessment, fine or penalty levied against it, to the extent that any of
     the foregoing is due and pay-


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                                                                               6

          able, except for any such assessment, fine or penalty that is
          currently being contested in good faith or as would not have a
          material adverse effect on the condition (financial or otherwise),
          prospects, earnings, business or properties of the Company whether or
          not arising from transactions in the ordinary course of business,
          except as set forth in or contemplated in the Prospectus (exclusive of
          any supplement thereto).

               (r)  No labor problem or dispute with the employees of the
          Company exists or, to the Company's best knowledge, is threatened or
          imminent, and the Company is not aware of any existing or imminent
          labor disturbance by the employees of any of its principal suppliers,
          contractors or customers, that could have a material adverse effect on
          the condition (financial or otherwise), prospects, earnings, business
          or properties of the Company whether or not arising from transactions
          in the ordinary course of business, except as set forth in or
          contemplated in the Prospectus (exclusive of any supplement thereto).

               (s)  The Company is insured by insurers of recognized financial
          responsibility against such losses and risks and in such amounts as
          are prudent and customary in the businesses in which the Company is
          engaged; all policies of insurance insuring the Company and its
          businesses, assets, employees, officers and directors are in full
          force and effect; the Company is in compliance with the terms of such
          policies in all material respects; and there are no claims by the
          Company under any such policy as to which any insurance company is
          denying liability or defending under a reservation of rights clause;
          the Company has not been refused any insurance coverage sought or
          applied for; and the Company has no reason to believe that it will not
          be able to renew its existing insurance coverage as and when such
          coverage expires or to obtain similar coverage from similar insurers
          as may be necessary to continue its business at a cost that would not
          have a material adverse effect on the condition (financial or
          otherwise), prospects, earnings, business or properties of the Company
          whether or not arising from transactions in the ordinary course of
          business, except as set forth in or contemplated in the Prospectus
          (exclusive of any supplement thereto).

               (t)  The Company possess all licenses, certificates, permits and
          other authorizations issued by the appropriate federal, state or
          foreign regulatory authorities necessary to conduct its businesses,
          and the Company has not received any notice of proceedings relating to
          the revocation or modification of any such certificate, authorization
          or permit which, singly or in the aggregate, if the subject of an
          unfavorable decision, ruling or finding, would have a material adverse
          effect on the condition (financial or otherwise), prospects, earnings,
          business or properties of the Company whether or not arising from
          transactions in the ordinary course of business, except as set forth
          in or contemplated in the Prospectus (exclusive of any supplement
          thereto).


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                                                                               7

               (u)  The Company maintains a system of internal accounting
          controls sufficient to provide reasonable assurance that (i)
          transactions are executed in accordance with management's general or
          specific authorizations; (ii) transactions are recorded as necessary
          to permit preparation of financial statements in conformity with
          generally accepted accounting principles and to maintain asset
          accountability; (iii) access to assets is permitted only in accordance
          with management's general or specific authorization; and (iv) the
          recorded accountability for assets is compared with the existing
          assets at reasonable intervals and appropriate action is taken with
          respect to any differences.

               (v)  The Company has not taken, directly or indirectly, any
          action that has constituted or that was designed to or might
          reasonably be expected to cause or result in, under the Exchange Act
          or otherwise, the stabilization or manipulation of the price of any
          security of the Company to facilitate the sale or resale of the
          Securities.

               (w)  The Company (i) is in compliance with any and all applicable
          foreign, federal, state and local laws and regulations relating to the
          protection of human health and safety, the environment or hazardous or
          toxic substances or wastes, pollutants or contaminants ("Environmental
          Laws"), (ii) has received and is in compliance with all permits,
          licenses or other approvals required of it under applicable
          Environmental Laws to conduct its businesses and (iii) has not
          received notice of any actual or potential liability for the
          investigation or remediation of any disposal or release of hazardous
          or toxic substances or wastes, pollutants or contaminants, except
          where such non-compliance with Environmental Laws, failure to receive
          required permits, licenses or other approvals, or liability would not,
          individually or in the aggregate, have a material adverse change in
          the condition (financial or otherwise), prospects, earnings, business
          or properties of the Company whether or not arising from transactions
          in the ordinary course of business, except as set forth in or
          contemplated in the Prospectus (exclusive of any supplement thereto).
          Except as set forth in the Prospectus, the Company has not been named
          as a "potentially responsible party" under the Comprehensive
          Environmental Response, Compensation, and Liability Act of 1980, as
          amended.

               (x)  The Company periodically has reviewed the effect of
          Environmental Laws on the business, operations and properties of the
          Company, in the course of which it identified and evaluated associated
          costs and liabilities (including, without limitation, any capital or
          operating expenditures required for clean-up, closure of properties or
          compliance with Environmental Laws, or any permit, license or
          approval, any related constraints on operating activities and any
          potential liabilities to third parties). On the basis of such review,
          the Company has reasonably concluded that such associated costs and
          liabilities would not, singly or in the


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                                                                               8

          aggregate, have a material adverse effect on the condition (financial
          or otherwise), prospects, earnings, business or properties of the
          Company whether or not arising from transactions in the ordinary
          course of business, except as set forth in or contemplated in the
          Prospectus (exclusive of any supplement thereto).

               (y)  The Company has fulfilled its obligations, if any, under the
          minimum funding standards of Section 302 of the United States Employee
          Retirement Income Security Act of 1974 ("ERISA") and the regulations
          and published interpretations thereunder with respect to each "plan"
          (as defined in Section 3(3) of ERISA and such regulations and
          published interpretations) in which employees of the Company are
          eligible to participate and each such plan is in compliance in all
          material respects with the presently applicable provisions of ERISA
          and such regulations and published interpretations. The Company has
          not incurred any unpaid liability to the Pension Benefit Guaranty
          Corporation (other than for the payment of premiums in the ordinary
          course) or to any such plan under Title IV of ERISA.

               (z)  The Company does not own any equity interests of any other
          entity.

               (aa) The Company has no issued patents. The Company owns,
          possesses, licenses or has other rights to use all patents, patent
          applications, trade and service marks, trade and service mark
          registrations, trade names, copyrights, licenses, inventions,
          trade secrets, technology, know-how and other intellectual property
          necessary for the conduct of the Company's business as now
          conducted and, to the Company's knowledge, as proposed in the
          Prospectus to be conducted (collectively, the "Intellectual
          Property"). With respect to the Intellectual Property, other than
          as set forth in the Prospectus or disclosed to the Representatives,
          (a) there are no rights of third parties to any Intellectual
          Property or Deltagen's rights under the License Agreements; (b) to
          the Company's knowledge, there is no infringement by third parties
          of any patent claim, service mark or trademark under the
          Intellectual Property; (c) there is no pending or, to the Company's
          knowledge, threatened action, suit, proceeding or claim by others
          challenging the Company's title, license or other rights in and to
          any Intellectual Property, and the Company does not have actual
          current knowledge of any facts which would form the reasonable
          basis for any such claim; (d) there is no pending or, to the
          Company's knowledge, threatened action, suit, proceeding or claim
          by others challenging the validity or scope of any patent claim,
          service mark or trademark under the Intellectual Property, and the
          Company does not have actual current knowledge of any facts which
          would form the reasonable basis for any such claim; (e) there is no
          pending or, to the Company's knowledge, threatened action, suit,
          proceeding or claim by others that the Company infringes or
          otherwise violates any patent, trademark, copyright, trade secret
          or other proprietary rights of others, and the Company does not
          have actual current knowledge of any facts which would form the
          reasonable basis for any such claim other than claims as to which
          the Company believes it would prevail; and (f)

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                                                                               9

          Deltagen is in compliance with 37 C.F.R. Section 1.56 to the extent
          that such compliance is required; except, in each case, other than
          such rights, infringements, actions, suits, proceedings or claims
          that, either individually or in the aggregate, would not have a
          Material Adverse Effect.

               (bb) The statements contained in the Prospectus under the
          captions "Risk Factors--We currently have no patents, and if we are
          unable to protect our proprietary information, our business will be
          adversely affected," "Risk Factors--We may be subject to litigation
          and infringement claims which may be costly and divert management's
          attention," "Risk Factors--Because we do not have any issued patents,
          and because knockout mouse and gene-related patents even if obtained
          may not be enforceable, our intellectual property may not have any
          material value, which would diminish our business prospects," "Risk
          Factors--Our rights to the use of technologies licensed to us by third
          parties are not within our control, and without these technologies,
          our products and programs may not be successful and our business
          prospects could be harmed," "Risk Factors--Compliance with
          governmental regulations could increase our operating costs or
          adversely affect our customers' ability to obtain governmental
          approval of gene-based products, which would adversely affect the
          commercialization of our technology," "Risk Factors--Our incorporation
          documents and Delaware law may inhibit a takeover that stockholders
          consider favorable and could also limit the market price of your
          stock," "Risk Factors--The future sale of common stock could
          negatively affect our stock price," "Business--Intellectual Property,"
          "Business--Governmental Regulation," "Business--Legal Proceedings,"
          "Description of Capital Stock--Anti-Takeover Provisions of our Amended
          and Restated Certificate of Incorporation and By-laws and Delaware
          law," "Shares Eligible for Future Sale," and "U.S. Tax Consequences to
          Non-U.S. Holders," insofar as such statements summarize legal matters,
          agreements, documents or proceedings discussed therein, are accurate
          and fair summaries of such legal matters, agreements, documents or
          proceedings.

               (cc) The Company has such permits, licenses, franchises,
          authorizations and clearances ("Permits") of governmental or
          regulatory authorities, and/or any committee thereof, as are necessary
          to own, lease and operate its properties and to conduct its business
          in the manner described in the Prospectus, except where such failure
          to receive such Permits would not, individually or in the aggregate,
          have a material adverse effect on the condition (financial or
          otherwise), prospects, earnings, business or properties of the Company
          whether or not arising from transactions in the ordinary course of
          business, except as set forth in or contemplated in the Prospectus
          (exclusive of any supplement thereto); the Company has fulfilled and
          performed all its material obligations with respect to the Permits; no
          event has occurred which allows, or after notice or lapse of time
          would allow, revocation or termination thereof or results in any other
          material impairment of the rights of the holder of any Permit;


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                                                                              10

          and none of the Permits contains any restriction that is materially
          burdensome to the Company.

                    (dd) Except as disclosed in the Registered Statement and the
          Prospectus, the Company (i) does not have any material lending or
          other relationship with any bank or lending institution which is an
          affiliate of any of the Underwriters and (ii) does not intend to use
          any of the proceeds from the sale of the Securities hereunder to repay
          any outstanding debt owed to any affiliate of any of the Underwriters.

     Any certificate signed by any officer of the Company and delivered to the
Representatives or counsel for the Underwriters in connection with the offering
of the Securities shall be deemed a representation and warranty by the Company,
as to matters covered thereby, to each Underwriter.

     Furthermore, the Company represents and warrants to Salomon Smith Barney
Inc. that (i) the Registration Statement, the Prospectus and any preliminary
prospectus comply, and any further amendments or supplements thereto will
comply, with any applicable laws or regulations of non-U.S. jurisdictions in
which the Prospectus or any preliminary prospectus, as amended or supplemented,
if applicable, are distributed in connection with the Directed Share Program,
and that (ii) no authorization, approval, consent, license, order, registration
or qualification of or with any government, governmental instrumentality or
court, other than such as have been obtained, is necessary under the securities
laws and regulations of foreign jurisdictions in which the Directed Shares are
offered outside the United States.

     2.   PURCHASE AND SALE. (a) Subject to the terms and conditions and in
reliance upon the representations and warranties herein set forth, the Company
agrees to sell to each Underwriter, and each Underwriter agrees, severally and
not jointly, to purchase from the Company, at a purchase price of $       per
share, the amount of the Underwritten Securities set forth opposite such
Underwriter's name in Schedule I hereto.

     (b)  Subject to the terms and conditions and in reliance upon the
representations and warranties herein set forth, the Company hereby grants an
option to the several Underwriters to purchase, severally and not jointly, up to
1,050,000 Option Securities at the same purchase price per share as the
Underwriters shall pay for the Underwritten Securities. Said option may be
exercised only to cover over-allotments in the sale of the Underwritten
Securities by the Underwriters. Said option may be exercised in whole or in part
at any time (but not more than once) on or before the 30th day after the date of
the Prospectus upon written or facsimile notice by the Representatives to the
Company setting forth the number of shares of the Option Securities as to which
the several Underwriters are exercising the option and the settlement date. The
number of Option Securities to be purchased by each Underwriter shall be the
same percentage of the total number of shares of the Option


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                                                                              11

Securities to be purchased by the several Underwriters as such Underwriter is
purchasing of the Underwritten Securities, subject to such adjustments as you in
your absolute discretion shall make to eliminate any fractional shares.

     3.   DELIVERY AND PAYMENT. Delivery of and payment for the Underwritten
Securities and the Option Securities (if the option provided for in Section 2(b)
hereof shall have been exercised on or before the third Business Day prior to
the Closing Date) shall be made at 10:00 AM, New York City time, on [      ],
2000, or at such time on such later date not more than three Business Days after
the foregoing date as the Representatives shall designate, which date and time
may be postponed by agreement between the Representatives and the Company or as
provided in Section 9 hereof (such date and time of delivery and payment for the
Securities being herein called the "Closing Date"). Delivery of the Securities
shall be made to the Representatives for the respective accounts of the several
Underwriters against payment by the several Underwriters through the
Representatives of the purchase price thereof to or upon the order of the
Company by wire transfer payable in same-day funds to an account specified by
the Company. Delivery of the Underwritten Securities and the Option Securities
shall be made through the facilities of The Depository Trust Company unless the
Representatives shall otherwise instruct.

     If the option provided for in Section 2(b) hereof is exercised after the
third Business Day prior to the Closing Date, the Company will deliver the
Option Securities (at the expense of the Company) to the Representatives, at 388
Greenwich Street, New York, New York, on the date specified by the
Representatives (which shall be within three Business Days after exercise of
said option) for the respective accounts of the several Underwriters, against
payment by the several Underwriters through the Representatives of the purchase
price thereof to or upon the order of the Company by wire transfer payable in
same-day funds to an account specified by the Company. If settlement for the
Option Securities occurs after the Closing Date, the Company will deliver to the
Representatives on the settlement date for the Option Securities, and the
obligation of the Underwriters to purchase the Option Securities shall be
conditioned upon receipt of, supplemental opinions, certificates and letters
confirming as of such date the opinions, certificates and letters delivered on
the Closing Date pursuant to Section 6 hereof.

     4.   OFFERING BY UNDERWRITERS. It is understood that the several
Underwriters propose to offer the Securities for sale to the public as set forth
in the Prospectus.


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                                                                              12

     5.   AGREEMENTS. The Company agrees with the several Underwriters that:

          (a)  The Company will use its best efforts to cause the Registration
     Statement, if not effective at the Execution Time, and any amendment
     thereof, to become effective. Prior to the termination of the offering of
     the Securities, the Company will not file any amendment of the Registration
     Statement or supplement to the Prospectus or any Rule 462(b) Registration
     Statement unless the Company has furnished you a copy for your review prior
     to filing and will not file any such proposed amendment or supplement to
     which you reasonably object. Subject to the foregoing sentence, if the
     Registration Statement has become or becomes effective pursuant to Rule
     430A, or filing of the Prospectus is otherwise required under Rule 424(b),
     the Company will cause the Prospectus, properly completed, and any
     supplement thereto to be filed with the Commission pursuant to the
     applicable paragraph of Rule 424(b) within the time period prescribed and
     will provide evidence satisfactory to the Representatives of such timely
     filing. The Company will promptly advise the Representatives (1) when the
     Registration Statement, if not effective at the Execution Time, shall have
     become effective, (2) when the Prospectus, and any supplement thereto,
     shall have been filed (if required) with the Commission pursuant to Rule
     424(b) or when any Rule 462(b) Registration Statement shall have been filed
     with the Commission, (3) when, prior to termination of the offering of the
     Securities, any amendment to the Registration Statement shall have been
     filed or become effective, (4) of any request by the Commission or its
     staff for any amendment of the Registration Statement, or any Rule 462(b)
     Registration Statement, or for any supplement to the Prospectus or for any
     additional information, (5) of the issuance by the Commission of any stop
     order suspending the effectiveness of the Registration Statement or the
     institution or threatening of any proceeding for that purpose and (6) of
     the receipt by the Company of any notification with respect to the
     suspension of the qualification of the Securities for sale in any
     jurisdiction or the institution or threatening of any proceeding for such
     purpose. The Company will use its best efforts to prevent the issuance of
     any such stop order or the suspension of any such qualification and, if
     issued, to obtain as soon as possible the withdrawal thereof.

          (b)  If, at any time when a prospectus relating to the Securities is
     required to be delivered under the Act, any event occurs as a result of
     which the Prospectus as then supplemented would include any untrue
     statement of a material fact or omit to state any material fact necessary
     to make the statements therein in the light of the circumstances under
     which they were made not misleading, or if it shall be necessary to amend
     the Registration Statement or supplement the Prospectus to comply with the
     Act or the rules thereunder, the Company promptly will (1) notify the
     Representatives of any such event, (2) prepare and file with the
     Commission, subject to the second sentence of paragraph (a) of this Section
     5, an amendment or supplement which will correct such statement or omission
     or effect such compliance;


<PAGE>

                                                                              13

     and (3) supply any supplemented Prospectus to you in such quantities as you
     may reasonably request.

          (c)  As soon as practicable, the Company will make generally available
     to its security holders and to the Representatives an earnings statement or
     statements of the Company which will satisfy the provisions of Section
     11(a) of the Act and Rule 158 under the Act.

          (d)  The Company will furnish to the Representatives and counsel for
     the Underwriters signed copies of the Registration Statement (including
     exhibits thereto) and to each other Underwriter a copy of the Registration
     Statement (without exhibits thereto) and, so long as delivery of a
     prospectus by an Underwriter or dealer may be required by the Act, as many
     copies of each Preliminary Prospectus and the Prospectus and any supplement
     thereto as the Representatives may reasonably request.

          (e)  The Company will arrange, if necessary, for the qualification of
     the Securities for sale under the laws of such jurisdictions as the
     Representatives may designate and will maintain such qualifications in
     effect so long as required for the distribution of the Securities; provided
     that in no event shall the Company be obligated to qualify to do business
     or subject itself to taxation in respect thereof in any jurisdiction where
     it is not now so qualified or to take any action that would subject it to
     service of process in suits, other than those arising out of the offering
     or sale of the Securities, in any jurisdiction where it is not now so
     subject.

          (f)  The Company will not, without the prior written consent of
     Salomon Smith Barney Inc., offer, sell, contract to sell, pledge, or
     otherwise dispose of, (or enter into any transaction which is designed to,
     or might reasonably be expected to, result in the disposition (whether by
     actual disposition or effective economic disposition due to cash settlement
     or otherwise) by the Company or any affiliate of the Company or any person
     in privity with the Company or any affiliate of the Company) directly or
     indirectly, including the filing (or participation in the filing) of a
     registration statement with the Commission in respect of, or establish or
     increase a put equivalent position or liquidate or decrease a call
     equivalent position within the meaning of Section 16 of the Exchange Act,
     any other shares of Common Stock or any securities convertible into, or
     exercisable, or exchangeable for, shares of Common Stock; or publicly
     announce an intention to effect any such transaction, for a period of 180
     days after the date of the Underwriting Agreement, PROVIDED, HOWEVER, that
     the Company may issue and sell Common Stock or options to purchase Common
     Stock, pursuant to any employee stock option plan, stock ownership plan,
     employee stock purchase plan or dividend reinvestment plan of the Company
     in effect at the Execution Time and the Company may issue Common Stock
     issuable upon the con-


<PAGE>

                                                                              14

     version of securities or the exercise of warrants outstanding at the
     Execution Time.

          (g)  The Company will not take, directly or indirectly, any action
     designed to or which has constituted or which might reasonably be expected
     to cause or result, under the Exchange Act or otherwise, in stabilization
     or manipulation of the price of any security of the Company to facilitate
     the sale or resale of the Securities.

          (h)  The Company agrees to pay the costs and expenses relating to the
     following matters: (i) the preparation, printing or reproduction and filing
     with the Commission of the Registration Statement (including financial
     statements and exhibits thereto), each Preliminary Prospectus, the
     Prospectus, and each amendment or supplement to any of them; (ii) the
     printing (or reproduction) and delivery (including postage, air freight
     charges and charges for counting and packaging) of such copies of the
     Registration Statement, each Preliminary Prospectus, the Prospectus, and
     all amendments or supplements to any of them, as may, in each case, be
     reasonably requested for use in connection with the offering and sale of
     the Securities; (iii) the preparation, printing, authentication, issuance
     and delivery of certificates for the Securities, including any stamp or
     transfer taxes in connection with the original issuance and sale of the
     Securities; (iv) the printing (or reproduction) and delivery of this
     Agreement, any blue sky memorandum and all other agreements or documents
     printed (or reproduced) and delivered in connection with the offering of
     the Securities; (v) the registration of the Securities under the Exchange
     Act and the listing of the Securities on the Nasdaq National Market; (vi)
     any registration or qualification of the Securities for offer and sale
     under the securities or blue sky laws of the several states (including
     filing fees and the reasonable fees and expenses of counsel for the
     Underwriters relating to such registration and qualification); (vii) any
     filings required to be made with the National Association of Securities
     Dealers, Inc. (including filing fees and the reasonable fees and expenses
     of one counsel for the Underwriters relating to such filings); (viii) the
     transportation and other expenses incurred by or on behalf of Company
     representatives in connection with presentations to prospective purchasers
     of the Securities; (ix) the fees and expenses of the Company's accountants
     and the fees and expenses of counsel (including local and special counsel)
     for the Company; and (x) all other costs and expenses incident to the
     performance by the Company of its obligations hereunder.

          (i)  In connection with the Directed Share Program, the Company will
     ensure that certain of the Directed Shares will be restricted to the extent
     required by the National Association of Securities Dealers, Inc. (the
     "NASD") or the NASD rules from sale, transfer, assignment, pledge or
     hypothecation for a period of three months following the date of the
     effectiveness of the Registration Statement. Salomon Smith Barney Inc. will
     notify the Company as to which Participants will need to be so restricted.
     The Company will direct the removal of such transfer restrictions upon


<PAGE>

                                                                              15

     the expiration of such period of time.

          (j)  The Company will pay all fees and disbursements of counsel
     incurred by the Underwriters in connection with the Directed Share Program
     and stamp duties, similar taxes or duties or other taxes, if any, incurred
     by the Underwriters in connection with the Directed Share Program.

          (k)  The Company will comply with all applicable securities and other
     applicable laws, rules and regulations in each foreign jurisdiction in
     which the Directed Shares are offered in connection with the Directed Share
     Program.

     6.   CONDITIONS TO THE OBLIGATIONS OF THE UNDERWRITERS. The obligations of
the Underwriters to purchase the Underwritten Securities and the Option
Securities, as the case may be, shall be subject to the accuracy of the
representations and warranties on the part of the Company contained herein as of
the Execution Time, the Closing Date and any settlement date pursuant to Section
3 hereof, to the accuracy of the statements of the Company made in any
certificates pursuant to the provisions hereof, to the performance by the
Company of its obligations hereunder and to the following additional conditions:

          (a)  If the Registration Statement has not become effective prior to
     the Execution Time, unless the Representatives agree in writing to a later
     time, the Registration Statement will become effective not later than (i)
     6:00 PM New York City time on the date of determination of the public
     offering price, if such determination occurred at or prior to 3:00 PM New
     York City time on such date or (ii) 9:30 AM on the Business Day following
     the day on which the public offering price was determined, if such
     determination occurred after 3:00 PM New York City time on such date; if
     filing of the Prospectus, or any supplement thereto, is required pursuant
     to Rule 424(b), the Prospectus, and any such supplement, will be filed in
     the manner and within the time period required by Rule 424(b); and no stop
     order suspending the effectiveness of the Registration Statement shall have
     been issued and no proceedings for that purpose shall have been instituted
     or threatened.


<PAGE>

                                                                              16

          (b)  The Company shall have requested and caused Pillsbury Madison &
     Sutro LLP, counsel for the Company, to have furnished to the
     Representatives their opinion, dated the Closing Date and addressed to the
     Representatives, to the effect that:

               (i)   The Company has been duly incorporated and is validly
          existing and is in good standing under the laws of the State of
          Delaware, and has all requisite corporate power and authority to own
          or lease, as the case may be, and to operate its properties and
          conduct its business as described in the Prospectus, and is duly
          qualified to do business as a foreign corporation and is in good
          standing under the laws of each jurisdiction which requires such
          qualification, except where the failure to be so qualified would not
          have a material adverse effect on the condition (financial or
          otherwise), prospects, earnings, business or properties of the
          Company, whether or not arising from transactions in the ordinary
          course of business;

               (ii)  the Company's authorized equity capitalization is as set
          forth in the Prospectus; the capital stock of the Company conforms in
          all material respects to the description thereof contained in the
          Prospectus; the outstanding shares of Common Stock have been duly and
          validly authorized and issued and are fully paid and nonassessable;
          the Securities have been duly and validly authorized, and, when issued
          and delivered to and paid for by the Underwriters pursuant to this
          Agreement, will be fully paid and nonassessable; the Securities are
          duly listed, and admitted and authorized for trading, subject to
          official notice of issuance and evidence of satisfactory distribution,
          on the Nasdaq National Market; the certificates for the Securities are
          in valid and sufficient form; the holders of outstanding shares of
          capital stock of the Company are not entitled to preemptive or other
          rights to subscribe for the Securities; and, except as set forth in
          the Prospectus, to the knowledge of such counsel, no options, warrants
          or other rights to purchase, agreements or other obligations to issue,
          or rights to convert any obligations into or exchange any securities
          for, shares of capital stock of or ownership interests in the Company
          are outstanding;

               (iii) to the knowledge of such counsel, there is no pending or
          threatened action, suit or proceeding by or before any court or
          governmental agency, authority or body or any arbitrator involving the
          Company or its property of a character required to be disclosed in the
          Registration Statement which is not adequately disclosed in the
          Prospectus, and there is no franchise, contract or other document of a
          character required to be described in the Registration Statement or
          Prospectus, or to be filed as an exhibit thereto, which is not
          described or filed as required; and the statements included in the


<PAGE>

                                                                              17

          Prospectus under the headings "Risk Factors -- Our incorporation
          documents and Delaware law may inhibit a takeover that stockholders
          consider favorable and could also limit the market price of your
          stock", "Risk Factors -- The future sale of common stock could
          negatively affect our stock price", "Business -- Legal Proceedings",
          "Description of Capital Stock -- Anti-Takeover Provisions of our
          Amended and Restated Certificate of Incorporation and By-laws and
          Delaware Law", "Shares Eligible For Future Sale" and "U.S.
          Consequences to Non-United States Holders", insofar as such statements
          summarize legal matters, agreements, documents, or proceedings
          discussed therein, are accurate and fair summaries of such legal
          matters, agreements, documents or proceedings;

               (iv)   the Registration Statement has become effective under the
          Act; any required filing of the Prospectus, and any supplements
          thereto, pursuant to Rule 424(b) has been made in the manner and
          within the time period required by Rule 424(b); to the knowledge of
          such counsel, no stop order suspending the effectiveness of the
          Registration Statement has been issued, no proceedings for that
          purpose have been instituted or, to the knowledge of such counsel,
          threatened and the Registration Statement and the Prospectus (other
          than the financial statements and other financial information
          contained therein, as to which such counsel need express no opinion)
          comply as to form in all material respects with the applicable
          requirements of the Act and the rules thereunder;

               (v)    this Agreement has been duly authorized, executed and
          delivered by the Company;

               (vi)   the Company is not and, immediately after giving effect to
          the offering and sale of the Securities and the receipt of the
          proceeds thereof as described in the Prospectus, will not be, an
          "investment company" as defined in the Investment Company Act of 1940,
          as amended;

               (vii)  no consent, approval, authorization, filing with or order
          of any court or governmental agency or body is required in connection
          with the transactions contemplated herein, except such as have been
          obtained under the Act and such as may be required under the blue sky
          laws of any jurisdiction in connection with the purchase and
          distribution of the Securities by the Underwriters in the manner
          contemplated in this Agreement and in the Prospectus and such other
          approvals (specified in such opinion) as have been obtained;

               (viii) neither the issue and sale of the Securities, nor the
          consummation of


<PAGE>

                                                                              18

          any other of the transactions herein contemplated nor the fulfillment
          of the terms hereof will conflict with, result in a breach or
          violation of or imposition of any lien, charge or encumbrance upon
          any property or assets of the Company pursuant to, (i) the Amended and
          Restated Certificate of Incorporation or by-laws of the Company, (ii)
          the terms of any indenture, contract, lease, mortgage, deed of trust,
          note agreement, loan agreement or other agreement, obligation,
          condition, covenant or instrument to which the Company is a party or
          bound or to which its property is subject and which are listed on an
          exhibit to such opinion, or (iii) any statute, law, rule, regulation,
          or, to our knowledge, any judgment, order or decree applicable to the
          Company of any court, regulatory body, administrative agency,
          governmental body, arbitrator or other authority having jurisdiction
          over the Company or any of its or their properties, which violation or
          default would, in the case of clauses (ii) and (iii) above, either
          individually or in the aggregate, have a material adverse effect on
          the condition (financial or otherwise), prospects, earnings, business
          or properties of the Company, whether or not arising from transactions
          in the ordinary course of business; and

               (ix) no holders of securities of the Company have rights to the
          registration of such securities under the Registration Statement.

     Such counsel shall also state that such counsel has no reason to believe
     that on the Effective Date or such later date, if any, the Registration
     Statement was last deemed amended the Registration Statement contained any
     untrue statement of a material fact or omitted to state any material fact
     required to be stated therein or necessary to make the statements therein
     not misleading or that the Prospectus as of its date and on the Closing
     Date included or includes any untrue statement of a material fact or
     omitted or omits to state a material fact necessary to make the statements
     therein, in the light of the circumstances under which they were made, not
     misleading (in each case, other than the financial statements and other
     financial information contained therein, as to which such counsel need
     express no opinion);

     Such opinion shall be limited in all respects to matters governed by the
     laws of the State of California, the General Corporate Law of Delaware and
     the Federal laws of the United States. As to matters of fact, to the extent
     they deem proper, on certificates of responsible officers of the Company
     and public officials. References to the Prospectus in this paragraph (b)
     include any supplements thereto at the Closing Date.

          (c)  Augustine Yee, Esq., the Company's General Counsel, shall have
     furnished to the Representatives his opinion, dated the Closing Date and
     addressed to the Representatives, to the effect that:

               (i)  to his knowledge, there is no pending or threatened action,
          suit or


<PAGE>

                                                                              19

          proceeding by or before any court or governmental agency, authority or
          body or any arbitrator involving the Company or its property of a
          character required to be disclosed in the Registration Statement which
          is not adequately disclosed in the Prospectus, and there is no
          franchise, contract or other document of a character required to be
          described in the Registration Statement or Prospectus, or to be filed
          as an exhibit thereto, which is not described or filed as required;
          and the statements included in the Prospectus under the headings "Risk
          Factors -- Our incorporation documents and Delaware law may inhibit a
          takeover that stockholders consider favorable and could also limit the
          market price of your stock", "Risk Factors -- The future sale of
          common stock could negatively affect our stock price", "Business --
          Legal Proceedings", "Description of Capital Stock -- Anti-Takeover
          Provisions of our Amended and Restated Certificate of Incorporation
          and By-laws and Delaware Law", "Shares Eligible For Future Sale" and
          "U.S. Consequences to Non-United States Holders", insofar as such
          statements summarize legal matters, agreements, documents, or
          proceedings discussed therein, are accurate and fair summaries of such
          legal matters, agreements, documents or proceedings;

               (ii)  he has no reason to believe that on the Effective Date or
          the date the Registration Statement was last deemed amended the
          Registration Statement contained any untrue statement of a material
          fact or omitted to state any material fact required to be stated
          therein or necessary to make the statements therein not misleading or
          that the Prospectus as of its date and on the Closing Date included or
          includes any untrue statement of a material fact or omitted or omits
          to state a material fact necessary to make the statements therein, in
          the light of the circumstances under which they were made, not
          misleading (in each case, other than the financial statements and
          other financial information contained therein, as to which he need
          express no opinion); and

               (iii) the Statements as they relate to the Intellectual Property
          and the License Agreements are accurate and fair summaries of the
          material legal matters and such License Agreements referred to
          therein.

          (d)  The Company shall have requested and caused Pillsbury Madison &
     Sutro LLP, patent counsel for the Company, to have furnished to the
     Representatives their opinion, dated the Closing Date and addressed to the
     Representatives, in the form of Exhibit B hereto.


<PAGE>

                                                                              20

          (e)  John Burke, Esq., the Company's Vice President of Intellectual
     Property, shall have furnished to the Representatives his opinion, dated
     the Closing Date and addressed to the Representatives in the form of
     Exhibit C hereto.

          (f)  The Company shall have requested and caused Hogan & Hartson
     L.L.P., regulatory counsel for the Company, to have furnished their
     opinion, dated the Closing Date and addressed to the Representatives in the
     form of Exhibit D hereto.

          (g)  Cooper & Dunham, patent counsel for Salomon Smith Barney Inc.
     shall have furnished to Salomon Smith Barney Inc. their opinions dated the
     Closing Date and addressed to Salomon Smith Barney Inc. which opinion shall
     be satisfactory in all respects to Salomon Smith Barney Inc.

          (h)  The Representatives shall have received from Cravath, Swaine &
     Moore, counsel for the Underwriters, such opinion or opinions, dated the
     Closing Date and addressed to the Representatives, with respect to the
     issuance and sale of the Securities, the Registration Statement, the
     Prospectus (together with any supplement thereto) and other related matters
     as the Representatives may reasonably require, and the Company shall have
     furnished to such counsel such documents as they request for the purpose of
     enabling them to pass upon such matters.

          (i)  The Company shall have furnished to the Representatives a
     certificate of the Company, signed by the Chairman of the Board or the
     President and the principal financial or accounting officer of the Company,
     dated the Closing Date, to the effect that the signers of such certificate
     have carefully examined the Registration Statement, the Prospectus, any
     supplements to the Prospectus and this Agreement and that:

               (i)   the representations and warranties of the Company in this
          Agreement are true and correct on and as of the Closing Date with the
          same effect as if made on the Closing Date and the Company has
          complied with all the agreements and satisfied all the conditions on
          its part to be performed or satisfied at or prior to the Closing Date;

               (ii)  no stop order suspending the effectiveness of the
          Registration Statement has been issued and no proceedings for that
          purpose have been instituted or, to the Company's knowledge,
          threatened; and

               (iii) since the date of the most recent financial statements
          included in the Prospectus (exclusive of any supplement thereto),
          there has been no material adverse effect on the condition (financial
          or otherwise), prospects, earnings, business or properties of the
          Company whether or not arising from trans-


<PAGE>

                                                                              21

          actions in the ordinary course of business, except as set forth in or
          contem plated in the Prospectus (exclusive of any supplement thereto).

          (j)  The Company shall have requested and caused
     PricewaterhouseCoopers LLP to have furnished to the Representatives, at the
     Execution Time and at the Closing Date, letters, dated respectively as of
     the Execution Time and as of the Closing Date, in form and substance
     satisfactory to the Representatives, confirming that they are independent
     accountants within the meaning of the Act and the applicable rules and
     regulations adopted by the Commission thereunder and that they have
     performed a review of the unaudited interim financial information of the
     Company for the three-month period ended March 31, 2000, and as at March
     31, 2000, in accordance with Statement on Auditing Standards No. 71 and
     stating in effect that:

               (i)  in their opinion the audited financial statements and
          financial statement schedules included in the Registration Statement
          and the Prospectus and reported on by them comply as to form in all
          material respects with the applicable accounting requirements of the
          Act and the related rules and regulations adopted by the Commission;


<PAGE>

                                                                             22

               (ii) on the basis of a reading of the latest unaudited financial
          statements made available by the Company; their limited review, in
          accordance with standards established under Statement on Auditing
          Standards No. 71, of the unaudited interim financial information for
          the three-month period ended March 31, 2000, and as at March 31, 2000;
          carrying out certain specified procedures (but not an examination in
          accordance with generally accepted auditing standards) which would not
          necessarily reveal matters of significance with respect to the
          comments set forth in such letter; a reading of the minutes of the
          meetings of the stockholders, directors and audit committee of the
          Company; and inquiries of certain officials of the Company who have
          responsibility for financial and accounting matters of the Company as
          to transactions and events subsequent to December 31, 1999, nothing
          came to their attention which caused them to believe that:

                    (1)  any unaudited financial statements included in the
               Registration Statement and the Prospectus do not comply as to
               form in all material respects with applicable accounting
               requirements of the Act and with the related rules and
               regulations adopted by the Commission with respect to
               registration statements on Form S-1; and said unaudited financial
               statements are not in conformity with generally accepted
               accounting principles applied on a basis substantially
               consistent with that of the audited financial statements included
               in the Registration Statement and the Prospectus;

                    (2)  with respect to the period subsequent to March 31,
               2000, there were any changes, at a specified date not more than
               five days prior to the date of the letter, in the capital lease
               obligations, less current portion and loans payable, less current
               portion of the Company or common stock of the Company or
               increases in the stockholders' deficit or decreases in total
               assets of the Company as compared with the amounts shown on the
               March 31, 2000, consolidated balance sheet included in the
               Registration Statement and the Prospectus, or for the period from
               April 1, 2000, to such specified date there were any (i)
               increases, as compared with the corresponding period in the
               immediately preceding quarter, in net loss or per share amounts
               of net loss or losses from operations of the Company or (ii)
               decreases, as compared with the corresponding period in the
               immediately preceding quarter, in contract revenue of the Company
               except, in all instances for changes, increases or decreases set
               forth in such letter, in which case the letter shall be
               accompanied by an explanation by the Company as to the
               significance thereof unless said explanation is not deemed
               necessary by the Representatives; or


<PAGE>

                                                                              23

                    (3)  the information included in the Registration Statement
               and Prospectus in response to Regulation S-K, Item 301 (Selected
               Financial Data), Item 302 (Supplementary Financial Information)
               and Item 402 (Executive Compensation) is not in conformity with
               the applicable disclosure requirements of Regulation S-K; and

               (iii) they have performed certain other specified procedures as a
          result of which they determined that certain information of an
          accounting, financial or statistical nature (which is limited to
          accounting, financial or statistical information derived from the
          general accounting records of the Company) set forth in the
          Registration Statement and the Prospectus, including the information
          set forth under the captions "Management's Discussion And Analysis Of
          Financial Condition And Results Of Operations", "Selected Financial
          Data", "Prospectus Summary--Summary Financial Data", "Capitalization",
          "Dilution", "Business" and "Risk Factors" in the Prospectus, agrees
          with the accounting records of the Company, excluding any questions of
          legal interpretation.

          References to the Prospectus in this paragraph (i) include any
     supplement thereto at the date of the letter.

          (k)  Subsequent to the Execution Time or, if earlier, the dates as of
     which information is given in the Registration Statement (exclusive of any
     amendment thereof) and the Prospectus (exclusive of any supplement
     thereto), there shall not have been (i) any change, increase or decrease
     specified in the letter or letters referred to in paragraph (h) of this
     Section 6 or (ii) any change, or any development involving a prospective
     change, in or affecting the condition (financial or otherwise), earnings,
     business or properties of the Company whether or not arising from
     transactions in the ordinary course of business, except as set forth in or
     contemplated in the Prospectus (exclusive of any supplement thereto) the
     effect of which, in any case referred to in clause (i) or (ii) above, is,
     in the sole judgment of the Representatives, so material and adverse as to
     make it impractical or inadvisable to proceed with the offering or delivery
     of the Securities as contemplated by the Registration Statement (exclusive
     of any amendment thereof) and the Prospectus (exclusive of any supplement
     thereto).

          (l)  Prior to the Closing Date, the Company shall have furnished to
     the Representatives such further information, certificates and documents as
     the Representatives may reasonably request.

          (m)  The Securities shall have been listed and admitted and authorized
     for trading on the Nasdaq National Market, and satisfactory evidence of
     such actions shall have been provided to the Representatives.


<PAGE>

                                                                              24

          (n)  At the Execution Time, the Company shall have furnished to the
     Representatives a letter substantially in the form of Exhibit A hereto from
     each officer and director of the Company and each other Shareholder of the
     Company addressed to the Representatives.

     If any of the conditions specified in this Section 6 shall not have been
fulfilled in all material respects when and as provided in this Agreement, or
if any of the opinions and certificates mentioned above or elsewhere in this
Agreement shall not be in all material respects reasonably satisfactory in form
and substance to the Representatives and counsel for the Underwriters, this
Agreement and all obligations of the Underwriters here under may be canceled at,
or at any time prior to, the Closing Date by the Representatives. Notice of such
cancelation shall be given to the Company in writing or by telephone or
facsimile confirmed in writing.

     The documents required to be delivered by this Section 6 shall be delivered
at the office of Cravath, Swaine & Moore, counsel for the Underwriters, at 825
Eight Avenue, New York, NY 10019, on the Closing Date.

     7.   REIMBURSEMENT OF UNDERWRITERS' EXPENSES. If the sale of the Securities
provided for herein is not consummated because any condition to the obligations
of the Underwriters set forth in Section 6 hereof is not satisfied, because of
any termination pursuant to Section 10 hereof or because of any refusal,
inability or failure on the part of the Company to perform any agreement herein
or comply with any provision hereof other than by reason of a default by any of
the Underwriters, the Company will reimburse the Underwriters severally through
Salomon Smith Barney Inc. on demand for all reasonable out-of-pocket expenses
(including reasonable fees and disbursements of counsel) that shall have been
incurred by them in connection with the proposed purchase and sale of the
Securities but the Company shall in no event be liable to any of the several
Underwriters for damages on account of the loss of anticipated profits from sale
of the Securities.

     8.   INDEMNIFICATION AND CONTRIBUTION. (a) The Company agrees to indemnify
and hold harmless each Underwriter, the directors, officers, employees and
agents of each Underwriter and each person who controls any Underwriter within
the meaning of either the Act or the Exchange Act against any and all losses,
claims, damages or liabilities, joint or several, to which they or any of them
may become subject under the Act, the Exchange Act or other Federal or state
statutory law or regulation, at common law or otherwise, insofar as such losses,
claims, damages or liabilities (or actions in respect thereof) arise out of or
are based upon any untrue statement or alleged untrue statement of a material
fact contained in the registration statement for the registration of the
Securities as originally filed or in any amendment thereof, or in any
Preliminary Prospectus or the Prospectus, or in any amendment thereof or
supplement thereto, or arise out of or are based upon the omission or alleged


<PAGE>

                                                                              25

omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, and agrees to reimburse
each such indemnified party, as incurred, for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; PROVIDED, HOWEVER, that the
Company will not be liable in any such case to the extent that any such loss,
claim, damage or liability arises out of or is based upon any such untrue
statement or alleged untrue statement or omission or alleged omission made
therein in reliance upon and in conformity with written information furnished to
the Company by or on behalf of any Underwriter through the Representatives
specifically for inclusion therein; provided further, that with respect to any
untrue statement or omission of material fact made in any Preliminary
Prospectus, the indemnity agreement contained in this Section 8(a) shall not
inure to the benefit of any Underwriter from whom the person asserting any such
loss, claim, damage or liability purchased the Securities concerned, to the
extent that any such loss, claim, damage or liability of such Underwriter occurs
under the circumstance where it shall have been determined by a court of
competent jurisdiction by final judgment that (w) the Company had previously
furnished copies of the Prospectus to the Representatives, (x) delivery of the
Prospectus was required by the Act to be made to such person, (y) the untrue
statement or omission of a material fact contained in the Preliminary Prospectus
was corrected in the Prospectus and (z) there was not sent or given to such
person, at or prior to the written confirmation of the sale of such securities
to such person, a copy of the Prospectus. This indemnity agreement will be in
addition to any liability which the Company may otherwise have.

     (b)  Each Underwriter severally and not jointly agrees to indemnify and
hold harmless the Company, each of its directors, each of its officers who signs
the Registration Statement, and each person who controls the Company within the
meaning of either the Act or the Exchange Act, to the same extent as the
foregoing indemnity from the Company to each Underwriter, but only with
reference to written information relating to such Underwriter furnished to the
Company by or on behalf of such Underwriter through the Representatives
specifically for inclusion in the documents referred to in the foregoing
indemnity. This indemnity agreement will be in addition to any liability which
any Underwriter may otherwise have. The Company acknowledges that the statements
set forth in the last paragraph of the cover page regarding delivery of the
Securities and, under the heading "Underwriting", (i) the list of Underwriters
and their respective participation in the sale of the Securities, (ii) the
sentences related to concessions and reallowances and (iii) the paragraph
related to stabilization, syndicate covering transactions and penalty bids in
any Preliminary Prospectus and the Prospectus constitute the only information
furnished in writing by or on behalf of the several Underwriters for inclusion
in any Preliminary Prospectus or the Prospectus.

     (c)  Promptly after receipt by an indemnified party under this Section 8 of
notice of the commencement of any action, such indemnified party will, if a
claim in respect


<PAGE>

                                                                              26

thereof is to be made against the indemnifying party under this Section 8,
notify the indemnifying party in writing of the commencement thereof; but the
failure so to notify the indemnifying party (i) will not relieve it from
liability under paragraph (a) or (b) above unless and to the extent it did not
otherwise learn of such action and such failure results in the forfeiture by the
indemnifying party of substantial rights and defenses and (ii) will not, in any
event, relieve the indemnifying party from any obligations to any indemnified
party other than the indemnification obligation provided in paragraph (a) or (b)
above. The indemnifying party shall be entitled to assume the defense and
appoint counsel of the indemnifying party's choice at the indemnifying party's
expense to represent the indemnified party in any action for which
indemnification is sought (in which case the indemnifying party shall not
thereafter be responsible for the fees and expenses of any separate counsel
retained by the indemnified party or parties except as set forth below);
PROVIDED, HOWEVER, that such counsel shall be satisfactory to the indemnified
party. Notwithstanding the indemnifying party's election to appoint counsel to
represent the indemnified party in an action, the indemnified party shall have
the right to employ separate counsel (including local counsel), and the
indemnifying party shall bear the reasonable fees, costs and expenses of such
separate counsel if (i) the use of counsel chosen by the indemnifying party to
represent the indemnified party would present such counsel with a conflict of
interest, (ii) the actual or potential defendants in, or targets of, any such
action include both the indemnified party and the indemnifying party and the
indemnified party shall have reasonably concluded that there may be legal
defenses available to it and/or other indemnified parties which are different
from or additional to those available to the indemnifying party, (iii) the
indemnifying party shall not have employed counsel satisfactory to the
indemnified party to represent the indemnified party within a reasonable time
after notice of the institution of such action or (iv) the indemnifying party
shall authorize the indemnified party to employ separate counsel at the expense
of the indemnifying party. An indemnifying party will not, without the prior
written consent of the indemnified parties, settle or compromise or consent to
the entry of any judgment with respect to any pending or threatened claim,
action, suit or proceeding in respect of which indemnification or contribution
may be sought hereunder (whether or not the indemnified parties are actual or
potential parties to such claim or action) unless such settlement, compromise or
consent includes an unconditional release of each indemnified party from all
liability arising out of such claim, action, suit or proceeding. Notwithstanding
anything contained herein to the contrary, if indemnity may be sought pursuant
to paragraph (e) of Section 8 hereof in respect of such action or proceeding,
then in addition to such separate firm for the indemnified parties, the
indemnifying party shall be liable for the reasonable fees and expenses of not
more than one separate firm (in addition to any local counsel) for Salomon Smith
Barney Inc., the directors, officers, employees and agents of Salomon Smith
Barney Inc., and all persons, if any, who control Salomon Smith Barney Inc.
within the meaning of either the Act or the Exchange Act for the defense of any
losses, claims, damages and liabilities arising out of the Directed Share
Program.

     (d)  In the event that the indemnity provided in paragraph (a), (b) or (e)
of


<PAGE>

                                                                              27

this Section 8 is unavailable to or insufficient to hold harmless an indemnified
party for any reason, the Company and the Underwriters severally agree to
contribute to the aggregate losses, claims, damages and liabilities (including
legal or other expenses reasonably incurred in connection with investigating or
defending same) (collectively "Losses") to which the Company and one or more of
the Underwriters may be subject in such proportion as is appropriate to reflect
the relative benefits received by the Company on the one hand and by the
Underwriters on the other from the offering of the Securities; PROVIDED,
HOWEVER, that in no case shall any Underwriter (except as may be provided in any
agreement among underwriters relating to the offering of the Securities) be
responsible for any amount in excess of the underwriting discount or commission
applicable to the Securities purchased by such Underwriter hereunder or (ii)
Salomon Smith Barney (the "Independent Underwriter") in its capacity as
"qualified independent underwriter" (within the meaning of National Association
of Securities Dealers, Inc. Conduct Rule 2720) be responsible for any amount in
excess of the compensation received by the Independent Underwriter for acting in
such capacity. If the allocation provided by the immediately preceding sentence
is unavailable for any reason, the Company and the Underwriters severally shall
contribute in such proportion as is appropriate to reflect not only such
relative benefits but also the relative fault of the Company on the one hand and
of the Underwriters on the other in connection with the statements or omissions
which resulted in such Losses as well as any other relevant equitable
considerations. Benefits received by the Company shall be deemed to be equal to
the total net proceeds from the offering (before deducting expenses) received by
it, and benefits received by the Underwriters shall be deemed to be equal to the
total underwriting discounts and commissions, in each case as set forth on the
cover page of the Prospectus. Benefits received by the Independent Underwriter
in its capacity as "qualified independent underwriter" shall be deemed to be
equal to the compensation received by the Independent Underwriter for acting in
such capacity. Relative fault shall be determined by reference to, among other
things, whether any untrue or any alleged untrue statement of a material fact or
the omission or alleged omission to state a material fact relates to information
provided by the Company on the one hand or the Underwriters on the other, the
intent of the parties and their relative knowledge, access to information and
opportunity to correct or prevent such untrue statement or omission. The Company
and the Underwriters agree that it would not be just and equitable if
contribution were determined by pro rata allocation or any other method of
allocation which does not take account of the equitable considerations referred
to above. Notwithstanding the provisions of this paragraph (d), no person guilty
of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act)
shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation. For purposes of this Section 8, each person who
controls an Underwriter within the meaning of either the Act or the Exchange Act
and each director, officer, employee and agent of an Underwriter shall have the
same rights to contribution as such Underwriter, and each person who controls
the Company within the meaning of either the Act or the Exchange Act, each
officer of the Company who shall have signed the Registration Statement and each
director of the Company shall have the same rights to contribution as the
Company, subject in each


<PAGE>

                                                                              28

case to the applicable terms and conditions of this paragraph (d).

     (e)  The Company agrees to indemnify and hold harmless Salomon Smith Barney
Inc., the directors, officers, employees and agents of Salomon Smith Barney Inc.
and each person, who controls Salomon Smith Barney Inc. within the meaning of
either the Act or the Exchange Act ("Salomon Smith Barney Inc. Entities"), from
and against any and all losses, claims, damages and liabilities to which they
may become subject under the Act, the Exchange Act or other federal or state
statutory law or regulation, at common law or otherwise (including, without
limitation, any legal or other expenses reasonably incurred in connection with
defending or investigating any such action or claim), insofar as such losses,
claims damages or liabilities (or actions in respect thereof) (i) arise out of
or are based upon any untrue statement or alleged untrue statement of a material
fact contained in the prospectus wrapper material prepared by or with the
consent of the Company for distribution in foreign jurisdictions in connection
with the Directed Share Program attached to the Prospectus or any preliminary
prospectus, or arise out of or are based upon the omission or alleged omission
to state therein a material fact required to be stated therein or necessary to
make the statement therein, when considered in conjunction with the Prospectus
or any applicable preliminary prospectus, not misleading; (ii) caused by the
failure of any Participant to pay for and accept delivery of the securities
which immediately following the Effective Date of the Registration Statement,
were subject to a properly confirmed agreement to purchase; PROVIDED that in any
such event the Company shall have the express right to mitigate such claims,
losses, liabilities or damages through the reallocation of any such Directed
Shares to the Participants; or (iii) related to, arising out of, or in
connection with the Directed Share Program, provided that, the Company will not
be liable in any such case to the extent that any such loss, claim, damage or
liability arises out of or is based upon any such untrue statement or alleged
untrue statement or omission or alleged omission made therein in reliance upon
and in conformity with written information furnished to the Company by or on
behalf of Salomon Smith Barney Inc. specifically for inclusion therein.

     (f)  Without limitation of and in addition to its obligations under the
other paragraphs of this Section 8, the Company agrees to indemnify and hold
harmless the Independent Underwriter, its directors, officers, employees and
agents and each person who controls Independent Underwriter within the meaning
of either the Act or the Exchange Act against any and all losses, claims,
damages or liabilities, joint or several, to which they or any of them may
become subject, insofar as such losses, claims, damages or liabilities (or
action in respect thereof) arise out of or are based upon Independent
Underwriter's acting as a "qualified independent underwriter" (within the
meaning of National Association of Securities Dealers, Inc. Conduct Rule 2720)
in connection with the offering contemplated by this Agreement, and agrees to
reimburse each such indemnified party, as incurred, for any legal or other
expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability or action; PROVIDED, HOWEVER,
that the Company will not be liable in any such case to the extent that any such
loss, claim, damage


<PAGE>

                                                                              29

or liability results from the gross negligence or willful misconduct of the
Independent Underwriter.

     9.   DEFAULT BY AN UNDERWRITER. If any one or more Underwriters shall fail
to purchase and pay for any of the Securities agreed to be purchased by such
Underwriter or Underwriters hereunder and such failure to purchase shall
constitute a default in the performance of its or their obligations under this
Agreement, the remaining Underwriters shall be obligated severally to take up
and pay for (in the respective proportions which the amount of Securities set
forth opposite their names in Schedule I hereto bears to the aggregate amount of
Securities set forth opposite the names of all the remaining Underwriters) the
Securities which the defaulting Underwriter or Underwriters agreed but failed to
purchase; PROVIDED, HOWEVER, that in the event that the aggregate amount of
Securities which the defaulting Underwriter or Underwriters agreed but failed to
purchase shall exceed 10% of the aggregate amount of Securities set forth in
Schedule I hereto, the remaining Underwriters shall have the right to purchase
all, but shall not be under any obligation to purchase any, of the Securities,
and if such nondefaulting Underwriters do not purchase all the Securities, this
Agreement will terminate without liability to any nondefaulting Underwriter or
the Company. In the event of a default by any Underwriter as set forth in this
Section 9, the Closing Date shall be postponed for such period, not exceeding
five Business Days, as the Representatives shall determine in order that the
required changes in the Registration Statement and the Prospectus or in any
other documents or arrangements may be effected. Nothing contained in this
Agreement shall relieve any defaulting Underwriter of its liability, if any, to
the Company and any nondefaulting Underwriter for damages occasioned by its
default hereunder.

     10.  TERMINATION. This Agreement shall be subject to termination in the
absolute discretion of the Representatives, by notice given to the Company prior
to delivery of and payment for the Securities, if at any time prior to such time
(i) trading in the Company's Common Stock shall have been suspended by the
Commission or the Nasdaq National Market or trading in securities generally on
the New York Stock Exchange or the Nasdaq National Market shall have been
suspended or limited or minimum prices shall have been established on such
Exchange or the Nasdaq National Market, (ii) a banking moratorium shall have
been declared either by Federal or New York State authorities or (iii) there
shall have occurred any outbreak or escalation of hostilities, declaration by
the United States of a national emergency or war, or other calamity or crisis
the effect of which on financial markets is such as to make it, in the sole
judgment of the Representatives, impractical or inadvisable to proceed with the
offering or delivery of the Securities as contemplated by the Prospectus
(exclusive of any supplement thereto).

     11.  REPRESENTATIONS AND INDEMNITIES TO SURVIVE. The respective agreements,
representations, warranties, indemnities and other statements of the Company or
its officers and of the Underwriters set forth in or made pursuant to this
Agreement will remain in full


<PAGE>

                                                                              30

force and effect, regardless of any investigation made by or on behalf of any
Underwriter or the Company or any of the officers, directors, employees, agents
or controlling persons referred to in Section 8 hereof, and will survive
delivery of and payment for the Securities. The provisions of Sections 7 and 8
hereof shall survive the termination or cancelation of this Agreement.

     12.  NOTICES. All communications hereunder will be in writing and effective
only on receipt, and, if sent to the Representatives, will be mailed, delivered
or telefaxed to the Salomon Smith Barney Inc. General Counsel (fax no.: (212)
816-7912) and confirmed to the General Counsel, Salomon Smith Barney Inc., at
388 Greenwich Street, New York, New York, 10013, Attention: General Counsel; or,
if sent to the Company, will be mailed, delivered or telefaxed to Deltagen,
Inc., 1005 Hamilton Avenue, Menlo Park, California 94025, Attention: General
Counsel (fax no.:(650) 752-0202) and confirmed to it at Pillsbury Madison &
Sutro LLP, 50 Fremont Street, San Francisco, California 94105, attention of
Cameo F. Jones.

     13.  SUCCESSORS. This Agreement will inure to the benefit of and be binding
upon the parties hereto and their respective successors and the officers,
directors, employees, agents and controlling persons referred to in Section 8
hereof, and no other person will have any right or obligation hereunder.

     14.  APPLICABLE LAW. This Agreement will be governed by and construed in
accordance with the laws of the State of New York applicable to contracts made
and to be performed within the State of New York.

     15.  COUNTERPARTS. This Agreement may be signed in one or more
counterparts, each of which shall constitute an original and all of which
together shall constitute one and the same agreement.

     16.  HEADINGS. The section headings used herein are for convenience only
and shall not affect the construction hereof.

     17.  DEFINITIONS. The terms which follow, when used in this Agreement,
shall have the meanings indicated.

          "Act" shall mean the Securities Act of 1933, as amended, and the rules
     and regulations of the Commission promulgated thereunder.

          "Business Day" shall mean any day other than a Saturday, a Sunday or a
     legal holiday or a day on which banking institutions or trust companies are
     authorized or obligated by law to close in New York City.

          "Commission" shall mean the Securities and Exchange Commission.


<PAGE>

                                                                              31

          "Effective Date" shall mean each date and time that the Registration
     Statement, any post-effective amendment or amendments thereto and any Rule
     462(b) Registration Statement became or become effective.

          "Exchange Act" shall mean the Securities Exchange Act of 1934, as
     amended, and the rules and regulations of the Commission promulgated
     thereunder.

          "Execution Time" shall mean the date and time that this Agreement is
     executed and delivered by the parties hereto.

          "Preliminary Prospectus" shall mean any preliminary prospectus
     referred to in paragraph 1(a) above and any preliminary prospectus included
     in the Registration Statement at the Effective Date that omits Rule 430A
     Information.

          "Prospectus" shall mean the prospectus relating to the Securities that
     is first filed pursuant to Rule 424(b) after the Execution Time or, if no
     filing pursuant to Rule 424(b) is required, shall mean the form of final
     prospectus relating to the Securities included in the Registration
     Statement at the Effective Date.

          "Registration Statement" shall mean the registration statement
     referred to in paragraph 1(a) above, including exhibits and financial
     statements, as amended at the Execution Time (or, if not effective at the
     Execution Time, in the form in which it shall become effective) and, in the
     event any post-effective amendment thereto or any Rule 462(b) Registration
     Statement becomes effective prior to the Closing Date, shall also mean such
     registration statement as so amended or such Rule 462(b) Registration
     Statement, as the case may be. Such term shall include any Rule 430A
     Information deemed to be included therein at the Effective Date as provided
     by Rule 430A.

          "Rule 424", "Rule 430A" and "Rule 462" refer to such rules under the
     Act.

          "Rule 430A Information" shall mean information with respect to the
     Securities and the offering thereof permitted to be omitted from the
     Registration Statement when it becomes effective pursuant to Rule 430A.

          "Rule 462(b) Registration Statement" shall mean a registration
     statement and any amendments thereto filed pursuant to Rule 462(b) relating
     to the offering covered by the registration statement referred to in
     Section 1(a) hereof.


<PAGE>

                                                                              32

     If the foregoing is in accordance with your understanding of our agreement,
please sign and return to us the enclosed duplicate hereof, whereupon this
letter and your acceptance shall represent a binding agreement among the Company
and the several Underwriters.

                                        Very truly yours,

                                        Deltagen, Inc.

                                        By:
                                           -------------------------------------
                                            Name:  William Matthews, Ph.D.
                                            Title: President and Chief Executive
                                                   Officer

The foregoing Agreement is hereby
confirmed and accepted as of the
date first above written.

Salomon Smith Barney Inc.
Robertson Stephens Inc.
U.S. Bancorp Piper Jaffray Inc.
Donaldson Lufkin & Jenrette Securities Corporation

By:  Salomon Smith Barney Inc.

By:
   --------------------------------
   Name:
   Title:

For themselves and the other
several Underwriters named in
Schedule I to the foregoing
Agreement.


<PAGE>

                                   SCHEDULE I

<TABLE>
<CAPTION>
                                                       NUMBER OF UNDERWRITTEN
                                                         SECURITIES TO BE
UNDERWRITERS                                                 PURCHASED
------------                                           ----------------------
<S>                                                    <C>
Salomon Smith Barney Inc.............................
Robertson Stephens Inc...............................
U.S. Bancorp Piper Jaffray Inc.......................
Donaldson, Lufkin & Jenrette Securities
  Corporation........................................

                                                           ------------

                  Total..............................         7,000,000
                                                           ============
</TABLE>


<PAGE>

                                                                       EXHIBIT A

                           [FORM OF LOCK-UP AGREEMENT]

                                 DELTAGEN, INC.
                         PUBLIC OFFERING OF COMMON STOCK

                                                                          [Date]

[Name underwriters]
 As Representatives of the several Underwriters
c/o [Lead underwriter]

Ladies and Gentlemen:

     This letter agreement is being delivered to you in connection with the
proposed Underwriting Agreement (the "Underwriting Agreement"), between
Deltagen, Inc., a Delaware corporation (the "Company"), and each of you as
representatives of a group of Underwriters named therein, relating to an
underwritten public offering (the "Offering") of Common Stock, $0.001 par value
(the "Common Stock"), of the Company.

     In order to induce you and the other Underwriters to enter into the
Underwriting Agreement, the undersigned will not, without the prior written
consent of Salomon Smith Barney Inc., offer, sell, contract to sell, pledge or
otherwise dispose of, or enter into any transaction which is designed to, or
might reasonably be expected to, result in the disposition (whether by actual
disposition or effective economic disposition due to cash settlement or
otherwise) by the undersigned or any affiliate of the undersigned or any person
in privity with the undersigned or any affiliate of the undersigned, directly or
indirectly, including the filing (or participation in the filing of) a
registration statement with the Securities and Exchange Commission in respect
of, or establish or increase a put equivalent position or liquidate or decrease
a call equivalent position within the meaning of Section 16 of the Securities
Exchange Act of 1934, as amended, and the rules and regulations of the
Securities and Exchange Commission promulgated thereunder with respect to, any
shares of capital stock of the Company or any securities convertible into, or
exercisable or exchangeable for such capital stock, or publicly announce an
intention to effect any such transaction, for a period of 180 days after the
date of the Underwriting Agreement, other than shares of capital stock (i)
disposed of as bona fide gifts approved by Salomon Smith Barney Inc., (ii)
distributed by will or intestacy to the undersigned's immediate family or to a
trust, the beneficiaries of which are exclusively the undersigned and/or a
member or members of his or her immediate family or (iii) as a distribution to
the limited partners or stockholders of the undersigned; provided that (A) any
such partner, affiliate, donee or other transferee of capital stock shall
acknowledge in writing that it is bound by the provisions of this lock-up
agreement and (B) no filing by any party (transferor or transferee) under
Section 16(a) of the Securities Exchange Act of 1934, as amended, shall be
required or shall be made voluntarily in connection with such transfer


<PAGE>

                                                                       EXHIBIT A

or distribution (other than a filing on Form 5 made after the expiration of the
180-day period referred to above). "Immediate family" shall mean the
undersigned's children, stepchildren, grandchildren, parents, stepparents,
grandparents, spouse, former spouses, siblings, nieces, nephews, mother-in-law,
father-in-law, sons-in-law, daughters-in-law, brothers-in-law or sisters-in-
law, including adoptive relationships, any person sharing the undersigned's
household (other than a tenant or employee), a trust in which these persons have
more than fifty percent of the beneficial interest, a foundation in which these
persons (or the undersigned) control the management of assets, and any other
entity in which those persons (or the undersigned) own more than fifty percent
of the voting interests.

     The undersigned further hereby agrees and consents to the entry of stop
transfer restrictions with the Company's transfer agent against the transfer of
capital stock held by the undersigned except in compliance with this letter
agreement.

     If for any reason the Underwriting Agreement shall be terminated prior to
the Closing Date (as defined in the Underwriting Agreement), this letter
agreement shall likewise be terminated. Additionally, this letter agreement
shall terminate and be of no further force and effect if the registration
statement with respect to the Offering is not declared effective by the
Securities and Exchange Commission by September 30, 2000.

                                        Yours very truly,


                                        -----------------------------
                                                  (Signature)

                                        -----------------------------
                                           (Print Name if an Entity)

                                        -----------------------------
                                          (Print Title if an Entity)

<PAGE>
                                                                      EXHIBIT B

                     [FORM OF INTELLECTUAL PROPERTY OPINION]

                  [Letterhead of Pillsbury Madison & Sutro LLP]

                                     [Date]

[Name underwriters]
  As Representatives of the several Underwriters
c/o [Lead underwriter]

Ladies and Gentlemen:

     We represent Deltagen, Inc., a Delaware corporation ("Deltagen"), in
connection with certain matters involving Deltagen's patent applications,
trademarks, trademark applications and service marks listed on Schedule 1 hereto
(collectively, "Intellectual Property").

     We are familiar with the Intellectual Property used in connection with
Deltagen's business and the manner of the use of such Intellectual Property as
described in the Prospectus dated ________, 2000 (the "Prospectus") that is part
of the Registration Statement on Form S-1 (File No. 333-34668) under the
Securities Act of 1933, as amended, and as further disclosed to us by Deltagen.
We have read the statements (the "Statements") under the following sections of
the Prospectus:

     1. "Risk Factors--We currently have no patents, and if we are unable to
     protect our proprietary information, our business will be adversely
     affected;"

     2. "Risk Factors--We may be subject to litigation and infringement claims
     which may be costly and divert management's attention;"

     3. "Risk Factors--Because we do not have any issued patents and because
     knockout mouse and gene-related patents, even if obtained, may not be
     enforceable, our intellectual property may not have any material value
     which would diminish our business prospects;"

     4. "Risk Factors--Our rights to the use of technologies licensed to us by
     third parties are not within our control, and without these technologies,
     our products and programs may not be successful and our business prospects
     could be harmed;" and

     5. "Business--Intellectual Property."

     Based upon and subject to the foregoing and further qualifications set
     forth below, it is our opinion that:

     (i) to our knowledge, after due inquiry, there are no facts that would
     preclude Deltagen from having (A) title to the Intellectual Property, free


<PAGE>

     and clear of liens which have been perfected by filing with the United
     States Patent and Trademark Office, or (B) valid and binding obligations
     under the license agreements listed on Schedule 2 attached hereto (the
     "License Agreements");

     (ii) except as described in the Prospectus or disclosed to the Underwriters
     in writing by Deltagen, (A) to our knowledge, there are no rights of third
     parties to any Intellectual Property; (B) to our knowledge, there is no
     infringement by third parties of any patent claim, service mark or
     trademark under such Intellectual Property; (C) to our knowledge after due
     inquiry, there is no pending or, to our knowledge, threatened action, suit,
     proceeding or claim against Deltagen by others challenging title to the
     Intellectual Property or Deltagen's rights under the License Agreements,
     and we are not aware of material facts which would form a reasonable basis
     for any such claim; (D) to our knowledge after due inquiry, there is no
     pending or, to our knowledge, threatened action, suit, proceeding or claim
     against Deltagen by others challenging the validity or scope of any patent
     claim, service mark or trademark under the Intellectual Property, and we
     are not aware of material facts which would form a reasonable basis for any
     such claim; (E) to our knowledge after due inquiry, there is no pending or,
     to our knowledge, threatened action, suit, proceeding or claim against
     Deltagen by others that Deltagen infringes or violates any patent,
     trademark or service mark of others, and we are not aware of material facts
     which would form a reasonable basis for any such claim; or (F) to our
     knowledge, Deltagen is in compliance with 37 C.F.R. Section 1.56 to the
     extent that such compliance is required; except, in each case, other than
     such rights, infringements, actions, suits, proceedings or claims that,
     either individually or in the aggregate, would not have a material adverse
     effect on the condition (financial or otherwise), prospects, earnings,
     business or properties of Deltagen, whether or not arising from
     transactions in the ordinary course of business;

     (iii) each of the patent applications, service mark applications and
     trademark applications set forth on Schedule 1 has been filed in the PTO or
     other comparable patent and trademark offices as set forth on Schedule 1
     and, to our knowledge, has not been abandoned, and we are not aware of any
     defects in the prosecution of any such application that would irrevocably
     foreclose pursuit of the patent rights thereunder; and

     (iv) the Statements as they relate to the Intellectual Property and the
     License Agreements are accurate and fair summaries of the material legal
     matters and such License Agreements referred to therein, provided that we
     express no opinion as to the legal proceedings between Deltagen and Lexicon
     Genetics, Inc.

     The foregoing opinions are subject to such matters as are set forth in the
Prospectus and the following qualifications:

     We have assumed the genuineness of all signatures, the authenticity of all
documents submitted to us as originals, the conformity to original documents of
all documents submitted to us as photostatic or telecopied


<PAGE>

originals, the legal capacity of all natural persons, and as to documents
executed by entities other than Deltagen, that each such entity has complied
with any applicable requirement to file tax returns and pay taxes under
California Franchise Tax law and had the power to enter into and perform its
obligations under such documents, and that such documents have been duly
authorized, executed and delivered by, and are binding upon and enforceable
against such entities.

     This opinion is limited in all respects to matters governed by the laws of
the State of California and the laws of the United States, and we express no
opinion concerning the laws or regulations of any other jurisdiction.

     Whenever a statement herein is qualified by "known to us," "to our
knowledge," "we are not aware" or similar phrase, it indicates that based solely
upon a review of materials in our files with respect to the Intellectual
Property and License Agreements and discussions with Deltagen's Chief Executive
Officer, Chief Scientific Officer and internal legal counsel, no information
that would give us knowledge of the inaccuracy of such statement has come to the
attention of the attorneys in this firm who have rendered legal services to
Deltagen and are working at Pillsbury Madison & Sutro LLP, as of the date
hereof. The phrase "after due inquiry" as used in paragraph (ii) above indicates
that we have only made a search of filings with United States District Court for
the Northern District of California. We have not made any other independent
investigation to determine the accuracy of such statements, except as expressly
described herein.

     This opinion is furnished by us as counsel for Deltagen to you as the
Underwriters and is solely for the benefit of the Underwriters.


                                           Very truly yours,



<PAGE>

                                   SCHEDULE 1

    PATENT APPLICATIONS, TRADEMARKS, TRADEMARK APPLICATIONS AND SERVICE MARKS

       [list of Deltagen patent applications, service marks, and trademark
                        applications in the PM&S docket]



<PAGE>

                                   SCHEDULE 2

                               LICENSE AGREEMENTS

Agreement dated as of December 23, 1998 between University of Edinburgh and
Deltagen, Inc.

Collaboration Agreement dated as of June 27, 2000 by and among Deltagen, Inc.,
Glaxo Group Limited and Glaxo Research and Development Limited.



<PAGE>
                                                                       EXHIBIT C

                     [FORM OF INTELLECTUAL PROPERTY OPINION]

                         [Letterhead of Deltagen, Inc.]

                                     [Date]

[Name underwriters]
  As Representatives of the several Underwriters
c/o [Lead underwriter]

Ladies and Gentlemen:

     I represent Deltagen, Inc., a Delaware corporation ("Deltagen"), in
connection with certain matters involving Deltagen's patent applications,
trademarks, trademark applications and service marks listed on Schedule 1 hereto
(collectively, "Intellectual Property").

     I am familiar with the Intellectual Property used in connection with
Deltagen's business and the manner of the use of such Intellectual Property as
described in the Prospectus dated ________, 2000 (the "Prospectus") that is part
of the Registration Statement on Form S-1 (File No. 333-34668) under the
Securities Act of 1933, as amended, and as further disclosed to me by the
officers of Deltagen. I have read the statements (the "Statements") under the
following sections of the Prospectus:

     1. "Risk Factors--We currently have no patents, and if we are unable to
     protect our proprietary information, our business will be adversely
     affected;"

     2. "Risk Factors--We may be subject to litigation and infringement claims
     which may be costly and divert management's attention;"

     3. "Risk Factors--Because we do not have any issued patents and because
     knockout mouse and gene-related patents, even if obtained, may not be
     enforceable, our intellectual property may not have any material value
     which would diminish our business prospects;"

     4. "Risk Factors--Our rights to the use of technologies licensed to us by
     third parties are not within our control, and without these technologies,
     our products and programs may not be successful and our business prospects
     could be harmed;" and

     5. "Business--Intellectual Property."

     Based upon and subject to the foregoing and further qualifications set
forth below, it is my opinion that:


<PAGE>

     (i) to my knowledge, after due inquiry, there are no facts that would
     preclude Deltagen from having (A) title to the Intellectual Property, free
     and clear of liens which have been perfected by filing with the United
     States Patent and Trademark Office, or (B) valid and binding obligations
     under the license agreements listed on Schedule 2 attached hereto (the
     "License Agreements");

     (ii) except as described in the Prospectus or disclosed to the Underwriters
     in writing by Deltagen, (A) to my knowledge, there are no rights of third
     parties to any Intellectual Property; (B) to my knowledge, there is no
     infringement by third parties of any patent claim, service mark or
     trademark under such Intellectual Property; (C) to my knowledge after due
     inquiry, there is no pending or, to my knowledge, threatened action, suit,
     proceeding or claim against Deltagen by others challenging title to the
     Intellectual Property or Deltagen's rights under the License Agreements,
     and we are not aware of material facts which would form a reasonable basis
     for any such claim; (D) to my knowledge after due inquiry, there is no
     pending or, to my knowledge, threatened action, suit, proceeding or claim
     against Deltagen by others challenging the validity or scope of any patent
     claim, service mark or trademark under the Intellectual Property, and we
     are not aware of material facts which would form a reasonable basis for any
     such claim; (E) to my knowledge after due inquiry, there is no pending or,
     to my knowledge, threatened action, suit, proceeding or claim against
     Deltagen by others that Deltagen infringes or violates any patent,
     trademark or service mark of others, and we are not aware of material facts
     which would form a reasonable basis for any such claim; or (F) to my
     knowledge, Deltagen is in compliance with 37 C.F.R. Section 1.56 to the
     extent that such compliance is required; except, in each case, other than
     such rights, infringements, actions, suits, proceedings or claims that,
     either individually or in the aggregate, would not have a material adverse
     effect on the condition (financial or otherwise), prospects, earnings,
     business or properties of Deltagen, whether or not arising from
     transactions in the ordinary course of business;

     (iii) each of the patent applications, service mark applications and
     trademark applications set forth on Schedule 1 has been filed in the PTO or
     other comparable patent and trademark offices as set forth on Schedule 1
     and has not been abandoned, and I am not aware of any defects in the
     prosecution of any such application that would irrevocably foreclose
     pursuit of the patent rights thereunder; and

     (iv) the Statements as they relate to the Intellectual Property are
     accurate and fair summaries of the material legal matters referred to
     therein.

     The foregoing opinions are subject to such matters as are set forth in the
Prospectus and the following qualifications:

     I have assumed the genuineness of all signatures, the authenticity of all
documents submitted to me as originals, the conformity to original documents of
all documents submitted to me as photostatic or telecopied originals, the


<PAGE>

legal capacity of all natural persons, and as to documents executed by entities
other than Deltagen, that each such entity has complied with any applicable
requirement to file tax returns and pay taxes under California Franchise Tax law
and had the power to enter into and perform its obligations under such
documents, and that such documents have been duly authorized, executed and
delivered by, and are binding upon and enforceable against such entities.

     This opinion is limited in all respects to matters governed by the laws of
the State of California and the laws of the United States, and I express no
opinion concerning the laws or regulations of any other jurisdiction.

     Whenever a statement herein is qualified by "known to me," "to my
knowledge," or similar phrase, it indicates that based solely upon a review of
materials in the Deltagen files with respect to the Intellectual Property and
License Agreements and discussions with the Deltagen's Chief Executive Officer,
Chief Scientific Officer and other internal legal counsel, no information that
would give me current actual knowledge of the inaccuracy of such statement has
come to my attention. The phrase "after due inquiry" as used in paragraph (ii)
above indicates that I have only made a search of filings with United States
District Court for the Northern District of California. I have not made any
other independent investigation to determine the accuracy of such statements,
except as expressly described herein.

     This opinion is furnished by me as counsel for Deltagen to you as the
Underwriters and is solely for the benefit of the Underwriters.


                                       Very truly yours,

<PAGE>

                                   SCHEDULE 1

    PATENT APPLICATIONS, TRADEMARKS, TRADEMARK APPLICATIONS AND SERVICE MARKS

        [list of Deltagen patent applications, service marks, trademarks,
                             trademark applications]



<PAGE>

                                   SCHEDULE 2

                               LICENSE AGREEMENTS

Agreement dated as of December 23, 1998 between University of Edinburgh and
Deltagen, Inc.

Collaboration Agreement dated as of June 27, 2000 by and among Deltagen, Inc.,
Glaxo Group Limited and Glaxo Research and Development Limited.



<PAGE>

                                                                       EXHIBIT D

                     [FORM OF GOVERNMENT REGULATION OPINION]

                     [Letterhead of Hogan & Hartson L.L.P.]

                                     [Date]

[Name underwriters]
  As Representatives of the several Underwriters
c/o [Lead underwriter]

Ladies and Gentlemen:

     This letter is furnished to you pursuant to Section _(_) of the
Underwriting Agreement dated _____ __, 2000 (the "Underwriting Agreement")
between you and Deltagen, Inc. (the "Company") relating to the sale by the
Company and purchase by you as Representatives of the several Underwriters of
___________ shares of common stock (the "Shares").

     This firm serves as special regulatory counsel to the Company with
respect to U.S. Food and Drug Administration ("FDA") and U.S. Department of
Agriculture ("USDA") regulatory matters arising under the Federal Food, Drug,
and Cosmetic Act, as amended (the "FDC Act"), the Animal Welfare Act ("AWA"),
a statute relating to the prevention of contagious diseases (21 U.S.C.
Section 111), and regulations promulgated thereunder (collectively, the
"FDA/USDA Regulatory Provisions"). In such limited capacity, we have reviewed
certain information under the captions "Risk Factors -- Compliance with
governmental regulations could increase our operating costs or adversely
affect our customers' ability to obtain governmental approval of gene based
products" and "Business -- Government Regulation," in the Company's final
Prospectus dated _____ __, 2000 (the "Prospectus"), forming a part of the
Company's Registration Statement on Form S-1, as amended (Registration No.
333-_____). We have not been retained or engaged by the Company to perform,
nor have we performed, any review of any other information in the Prospectus,
nor have we acted as the Company's corporate or securities counsel in
connection with the sale of the Shares. Terms used herein that are defined in
the Underwriting Agreement shall have the respective meanings set forth in
the Underwriting Agreement, unless otherwise defined herein.

     For purposes of the Opinion (as defined below), we have examined copies of
the following:

     1.   An executed copy of the Underwriting Agreement.


<PAGE>

                                                                               2

     2.   The information contained in the Prospectus under the captions "Risk
Factors -- Compliance with governmental regulations could increase our operating
costs or adversely affect our customers' ability to obtain governmental approval
of gene based products" and "Business -- Government Regulation,"

     3.   A certificate dated as of _______ __, 2000 of certain officers of the
Company as to certain facts relating to the Company.

     For purposes of the Opinion, we have not made any independent review or
investigation of factual or other matters, including the assets, business or
affairs of the Company. We have assumed the authenticity, accuracy and
completeness of the foregoing documents, certification and statements of fact,
on which we are relying, and have made no independent investigations thereof.
Further, for purposes of the Opinion, we have not independently verified, nor do
we take any responsibility for nor are we addressing in any way any statements
of fact, any statements concerning state or foreign law, any legal conclusions
or any statements of belief attributable to the Company or whether or not the
Company is in compliance with applicable FDA or USDA or other regulatory
requirements. The Opinion is given in the context of the foregoing.

     This letter is based as to matters of law solely on the FDA/USDA Regulatory
Provisions, and we express no view as to any other laws, statutes, regulations
or ordinances, including without limitation any foreign, federal or state
licensing, tax or securities laws or regulations.

     Nothing herein shall be construed to cause us to be considered "experts"
within the meaning of Section 11 of the Securities Act of 1933, as amended.

     Based upon, subject to and limited by the foregoing, we are of the opinion
that the statements in the Prospectus under the captions "Risk Factors --
Compliance with governmental regulations could increase our operating costs or
adversely affect our customers' ability to obtain governmental approval of gene
based products" and "Business -- Government Regulation," insofar as such
statements purport to summarize applicable provisions of the FDA/USDA Regulatory
Provisions, are accurate summaries in all material respects of the provisions
purported to be summarized under such captions in the Prospectus (the
"Opinion").

     During the course of preparation of the Registration Statement, we
participated in certain discussions with certain officers and employees of the
Company as to the FDA/USDA regulatory matters arising under the FDA/USDA
Regulatory Provisions and dealt with under the captions "Risk Factors --
Compliance with governmental regulations could increase our operating costs or
adversely affect our


<PAGE>

                                                                               3

customers' ability to obtain governmental approval of gene based products" and
"Business -- Government Regulation" in the Prospectus. While we have not
undertaken to determine independently, and we do not assume any responsibility
for, the accuracy, completeness, or fairness of the statements under the
above-referenced captions in the Prospectus, we may state on the basis of these
discussions and our activities as special regulatory counsel to the Company in
connection with our review of the statements contained in such captioned
sections that no facts have come to our attention that cause us to believe that
the statements in the Prospectus under such captioned sections, insofar as such
statements relate to FDA/USDA regulatory matters arising under the FDA/USDA
Regulatory Provisions, at the time the Registration Statement became effective,
contained an untrue statement of a material fact or omitted to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading, or as of the date hereof, contains an untrue statement of a
material fact or omits to state a material fact necessary in order to make the
statements therein, in the light of the circumstances under which they were
made, not misleading.

     We assume no obligation to advise you of any changes in the foregoing
subsequent to the delivery of this letter. This letter has been prepared solely
for your use in connection with the Closing under the Underwriting Agreement on
the date hereof, and should not be quoted in whole or in part or otherwise be
referred to, nor be filed with or furnished to any governmental agency or other
person or entity, without the prior written consent of this firm.


                                            Very truly yours,

                                            HOGAN & HARTSON
                                            L.L.P.




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