SELECT THERAPEUTICS INC
10KSB, EX-4.6, 2000-09-28
PHARMACEUTICAL PREPARATIONS
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                             STOCK OPTION AGREEMENT


     AGREEMENT, dated as of March 2, 2000, between SELECT THERAPEUTICS INC. (the
"Company"),  a Delaware  corporation  with offices at 124 Mount  Auburn  Street,
Suite  200  North,  Cambridge,  Massachusetts,  02138,  and DAWN  VAN ZANT  (the
"Optionee"),  residing at 145 Tyee Drive, Number 1573, Point Roberts, Washington
98281.

     WHEREAS,  the Company desires to recognize the Optionee's  achievements for
the Company  and provide  additional  incentive  to the  Optionee to utilize the
Optionee's  utmost  efforts to contribute to the  Company's  future  success and
prosperity  by giving the  Optionee an  opportunity  to  purchase  shares of its
common stock (the "Common Stock"), subject to the terms and conditions set forth
in this Agreement.

     NOW, THEREFORE, the parties hereto hereby agree as follows:

1. Option  Grant.  The Company  hereby  grants to the  Optionee  the option (the
"Option") to purchase 25,000 shares (the "Optioned Shares") of Common Stock from
the Company at a price of US $5.00 per share.  The Optionee shall have the right
to exercise the Option  immediately upon the execution of this Agreement through
and including March 1, 2007. The Option may be exercised in whole at any time or
in part  from  time  to time  during  the  exercise  period  and is  subject  to
adjustment as to price and number of shares as set forth in Section 5 hereof.

<PAGE>


2. Option Exercise;  Cashless Exercise. The Option may be exercised by notice to
the Company of the intent to exercise the Option,  an  acceptable  form of which
notice is set forth as Exhibit A hereto and made a part hereof,  specifying  the
number of Optioned  Shares in respect of which the Option is being exercised and
the Option  exercise  price and  accompanied by payment for such Shares by cash,
wire transfer or a bank or certified  check payable to the order of the Company.
This Option also is  exercisable  by a broker-  dealer,  acting on behalf of the
Optionee,  if (a) such broker-dealer and the Optionee shall agree to comply with
the applicable  provisions of Section 220.3(e)(4) of Regulation T of the Federal
Reserve  Board,  (b) if the  broker-dealer  agrees to remit the Option  exercise
price to the Company out of the net sales proceeds of the Optioned  Shares being
acquired and (c) if the Company  receives  written  instructions,  signed by the
Optionee,  requesting  the Company to deliver such Shares to such broker  dealer
and  specifying  the account  into which such Shares  should be  deposited.  The
Optionee  agrees to make adequate  provision for the payment of any  withholding
taxes due upon exercise of the Option.

3. Option  Transferable Only Upon the Death of the Optionee.  During the life of
the Optionee,  the Option shall not be transferable and may be exercised only by
the Optionee;  provided, however, that in the event of the death of the Optionee
prior  to the  Expiration  Date,  the  Option,  to the  extent  not  theretofore
exercised,  shall be  exercisable  in full by the  person to whom the  Option is
transferred by will or by the applicable laws of descent and  distribution,  and
the Option shall terminate upon its expiration date and not prior to such date.


                                       -2-
<PAGE>


4. Reservation of Common Stock. During the period within which the Option may be
exercised  the  Company  shall at all times have  authorized  and  reserved  for
issuance  upon such  exercise a  sufficient  number of shares of Common Stock to
provide for its exercise. The Company agrees that its issuance of this Agreement
shall constitute full authority to its officers who are charged with the duty of
causing  the  issuance of stock  certificates  of the Company to take all action
necessary or appropriate to cause to be issued the necessary stock  certificates
for the shares of Common Stock issuable upon the proper exercise of the Option.

5. Adjustment of Option Price and Number of Optioned Shares. With respect to the
Option granted hereunder, the Option price and the number and kind of securities
purchasable  upon the exercise of the Option shall be subject to adjustment from
time to time upon the occurrence of certain events as follows:

          (a) In case the  Company  shall  (i) pay a  dividend  in shares of its
     capital stock, (ii) subdivide its outstanding shares of Common Stock, (iii)
     reduce, consolidate, or combine its outstanding shares of Common Stock into
     a smaller number of shares, or (iv) issue by reclassification of its shares
     of Common Stock any shares of Common Stock of the Company, the Option price
     in effect  immediately  prior  thereto  shall be adjusted  to that  amount,
     determined by multiplying the Option price in effect  immediately  prior to
     such date by a  fraction,  of which the  numerator  shall be the  number of
     shares of Common Stock  outstanding  on such date before  giving  effect to
     such event,  and of which the denominator  shall be the number of shares of
     Common Stock outstanding after


                                       -3-
<PAGE>


     giving effect  thereto.  An  adjustment  made pursuant to this Section 5(a)
     shall become effective retroactively,  immediately after the record date in
     the case of a dividend,  and  immediately  after the effective  date in the
     case  of  a   subdivision,   reduction,   consolidation,   combination   or
     reclassification.  Each such adjustment shall be made successively whenever
     any such effective date or record date shall occur.

          (b) If the Common Stock issuable upon the exercise of the Option shall
     be changed  into the same or a  different  number of shares of any class or
     classes of stock,  whether by capital  reorganization,  reclassification or
     otherwise  (other  than a  subdivision  or  combination  of shares or stock
     dividend,  or a  reorganization,  merger,  consolidation  or sale of assets
     provided for in this Section 5), then, and in each such event, the Optionee
     shall  have  the  right  thereafter  to  receive,  without  payment  of any
     additional  consideration therefor, the kind and amount of shares of Common
     Stock and other securities  properly  receivable upon such  reorganization,
     reclassification  or other  change by  holders  of the  number of shares of
     Common Stock into which the Option might have been exercised, as reasonably
     determined by the Company's Board of Directors,  immediately  prior to such
     reorganization,   reclassification   or  change,  all  subject  to  further
     adjustment as provided in this Section 5.

          (c) If at any  time or from  time to time  there  shall  be a  capital
     reorganization of the Common Stock (other than a subdivision,  combination,
     reclassification or exchange of shares provided for in this Section 5) or a
     merger or consolidation of the Company with or into another corporation, or
     the sale of all or substantially all of the Company's properties and assets
     to any


                                       -4-
<PAGE>


     other person, then, as a part of such reorganization, merger, consolidation
     or sale, provision shall be made as reasonably  determined by the Company's
     Board of  Directors so that the Optionee  shall  thereafter  be entitled to
     receive  upon  exercise of the Option,  without  payment of any  additional
     consideration  therefor,  the  number of shares of  capital  stock or other
     securities  or  property  of the  Company or of the  successor  corporation
     resulting from such merger or  consolidation  or sale, to which a holder of
     Common  Stock  deliverable  upon  exercise  of the  Option  would have been
     entitled on such capital reorganization, merger, consolidation or sale.

          (d) Upon each adjustment in the Option price,  the number of shares of
     Common Stock purchasable  hereunder shall be adjusted, to the nearest whole
     share to the  product  obtained,  by  multiplying  the  number of shares of
     Common Stock purchasable immediately prior to such adjustment in the Option
     price by a  fraction,  the  numerator  of which  shall be the Option  price
     immediately  prior to such adjustment and the denominator of which shall be
     the Option price immediately thereafter.

          (e) The adjustments  provided for in this Section 5 are cumulative and
     shall   apply   to   successive   divisions,   subdivisions,    reductions,
     combinations,   consolidations,   issues,  distributions  or  other  events
     contemplated  herein  resulting in any  adjustment  under the provisions of
     this  Section  5;  provided,   however,  that,  notwithstanding  any  other
     provision  of this  Section 5, no  adjustment  of the Option price shall be
     required  if (1) the issue of Common  Stock is being made  pursuant  to any
     stock option or stock purchase plan in force from time to time for officers
     and/or employees of the Company, or any other option(including warrants)


                                       -5-
<PAGE>


     outstanding  at the date of  issuance  of this  Option or (2)  unless  such
     adjustment  would require an increase or decrease of more than five percent
     (5%) in the Option  price then in effect;  and provided  further,  however,
     that any  adjustments in the Option price,  which by reason of this Section
     5(e),  are not required then to be made shall be carried  forward and taken
     into account in any subsequent adjustment.

6. Certificate of Adjustment. Whenever the Option price is adjusted, as provided
in  Section 5 above,  the  Company  shall  promptly  deliver  to the  Optionee a
certificate of the principal  financial officer of the Company setting forth the
Option price after such  adjustment  and setting forth a brief  statement of the
facts requiring such adjustments and the calculation thereof.

7. No Fractional  Shares. No fractional shares of Common Stock will be issued in
connection  with any exercise of the Option.  In lieu of any  fractional  shares
which would  otherwise  be  issuable,  the  Company  shall pay cash equal to the
product of such fraction multiplied by the Option price in effect on the date of
exercise.

8.  Notice of Certain  Events.  If at any time prior to the  expiration  or full
exercise of the Option, the Company shall:

          (a) Take a record of the  holders  of any class of  securities  of the
     Company for the purpose of determining the holders thereof who are entitled
     to receive any dividend (other than a cash dividend at the same rate as the
     rate of the last cash dividend theretofore paid) or other distribution,  or
     any rights to subscribe  for,  purchase or otherwise  acquire any shares of
     capital


                                       -6-
<PAGE>


     stock of any class or any other  securities or property,  or to receive any
     other right;

          (b) Offer for  subscription pro rata to holders of Common Stock of the
     Company  any  additional  shares  of  capital  stock of any  class or other
     rights;

          (c)  Propose  any  capital   reorganization   of  the   Company,   any
     reclassification or recapitalization of the capital stock of the Company or
     any  consolidation  or  merger  of the  Company  with,  or  sale  of all or
     substantially  all  of its  assets  to,  another  corporation  or  business
     organization; or

          (d) Be  the  subject  of any  voluntary  or  involuntary  dissolution,
     liquidation or winding-up;

then,  in each such  event,  the  Company  shall  mail to the  Optionee a notice
specifying (i) the date or expected date on which any such record is to be taken
for the purpose of such dividend,  distribution  or right,  and (ii) the date or
expected   date   upon   which   any  such   reorganization,   reclassification,
recapitalization,  dissolution,  liquidation,  winding-up or offering is to take
place and the time,  if any,  to be fixed,  as of which the holders of record of
Common  Stock shall be entitled to  exchange  their  shares of Common  Stock for
securities   or   other   property   deliverable   upon   such   reorganization,
reclassification, recapitalization, dissolution, liquidation or winding-up. Such
notice shall be mailed at least forty-five (45) days prior to the earlier of the
dates specified in clauses (i) and (ii) above.


                                       -7-
<PAGE>


9. Rights as a Stockholder.

     (a) The Optionee  shall not be deemed for any purposes to be a  stockholder
of the Company with respect to any of the Optioned  Shares  except to the extent
that the Option shall have been duly  exercised  with respect  thereto.

     (b) The  existence  of an Option  shall not  affect in any way the right or
power  of the  Company  or its  stockholders  to  make or  authorize  any or all
adjustments, recapitalization, reorganizations or other changes in the Company's
capital  structure  or its  business,  or any  merger  or  consolidation  of the
Company, or any issue of bonds, debentures,  preferred or prior preference stock
ahead of or affecting the Common Stock or the rights thereof,  or dissolution or
liquidation  of the  Company or any sale or  transfer  of all or any part of its
assets or  business,  or any other  corporate  act or  proceeding,  whether of a
similar character or otherwise.

10. Compliance with Securities Laws.

     (a)  Until  such  time  as the  Optioned  Shares  shall  have  been  either
registered under the Securities Act of 1933, as amended (the "Securities  Act"),
or sold pursuant to an exemption  from  registration,  the Company shall utilize
its best efforts to comply with the  reporting  requirements  of Sections 13 and
15(d)  of the  Securities  Exchange  Act of 1934  (whether  or not it  shall  be
required to do so pursuant to such  sections)  and will use its best  efforts to
comply  with  all  other  public  information  reporting   requirements  of  the
Securities and Exchange  Commission (the "SEC") (including,  without limitation,
Rule 144  promulgated by the SEC under the Securities  Act) from time to time in
effect and relating


                                       -8-
<PAGE>


to the availability of an exemption from  registration  under the Securities Act
for the sale of restricted securities.  The Company also will cooperate with the
Optionee in supplying  such  information as may be necessary for the Optionee to
complete  and  file any  information  reporting  forms  presently  or  hereafter
required by the SEC as a condition to the availability of such an exemption.

     (b) Unless  prior to the  issuance  thereof the  Optioned  Shares  shall be
registered  under the  Securities  Act,  as a condition  precedent  to the valid
exercise of an Option the  Optionee  shall  represent  in writing to the Company
that he is acquiring  such Shares for his own account as an  investment  and not
with a view to, or for sale in connection with, the distribution of any thereof.
If the Optioned  Shares shall not be registered  under the  Securities Act at or
prior to the issuance  thereof,  each certificate  representing  Optioned Shares
shall bear a legend customary for securities not registered under the Securities
Act.

     (c) The Company will use its best efforts to qualify,  file or register the
Optioned  Shares in accordance  with the  securities  laws of such states of the
United States of America as may be reasonably  designated by the Optionee and to
obtain  the  consent,  authorization  or  approval  of any  governmental  agency
required in connection with the issuance of such Shares or which may be required
in order that the Optionee may otherwise publicly sell such Shares.

11. Notices.  All notices  required or desired to be given hereunder shall be in
writing and shall be deemed properly given to a party if personally delivered or
mailed by certified mail, return receipt requested, to such party at the address
set forth at the


                                       -9-
<PAGE>


head of this  Agreement or to such other address as shall be specified by notice
duly given. Notices given by certified mail shall be deemed given three business
days after the date of mailing,  and notices delivered in person shall be deemed
given on the date of delivery.

12. Entire  Agreement;  Breach and Waiver.  The provisions hereof constitute the
entire  agreement  between the parties with respect to the subject matter hereof
and supersede any prior written or oral understanding. This Agreement may not be
amended or modified in any manner,  except by an instrument in writing signed by
both parties  hereto.  The failure of either party hereto to enforce at any time
any of the provisions  hereof shall in no way be construed to be a waiver of any
such provision or any other provision,  or of the right of such party thereafter
to enforce each and every such  provision  or other  provision in the event of a
subsequent breach. Any waiver must be in writing and duly authorized.

13. Agreement Binding Upon Successors. This Agreement shall inure to the benefit
of, and shall be binding upon the Company,  its successors and assigns, and upon
the Optionee, his successors and assigns, heirs,  executors,  administrators and
legal representatives.


                                      -10-
<PAGE>


14. Counterparts.  This Agreement may be executed in several counterparts,  each
of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

15.  Construction.  This  Agreement  shall be  governed  by,  and  construed  in
accordance with, the local laws of the State of New York.

16.  Headings.  The headings  herein are solely for the convenience of reference
and shall be given no effect in the  construction or  interpretation  hereof and
shall not constitute, or be deemed to constitute, a part hereof.

     IN WITNESS  WHEREOF,  the  Company  and the  Optionee  have  executed  this
Agreement as of the day and year first above written.

                                              SELECT THERAPEUTICS INC.


                                              By:
                                                  ------------------------------
                                                  Robert Bender, Chairman


                                              Optionee:


                                              ----------------------------------
                                              Dawn van Zant


                                      -11-
<PAGE>


                                    EXHIBIT A


                                                  Date: __________________, 200_


Select Therapeutics Inc.
124 Mount Auburn Street
Suite 200 North
Cambridge, Massachusetts 02138

Attn: Chairman

          Re:  Exercise of Stock Option


Gentlemen:

     Please be advised  that I wish to  exercise my Stock  Option by  purchasing
_________  shares of Common Stock of the Company at the option price of US $ per
share. I enclose herewith a check in the amount of US  $_______________  in full
payment for said shares.

     Please deliver the certificate(s) to me at the following address:

                                                     Sincerely,


                                                     Name:
                                                          ----------------------

                                                     Address:
                                                             -------------------

                                                     ---------------------------

                                                     ---------------------------

                                                     Social Security Number:

                                                     ---------------------------

Enclosure

                                      -12-



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