MEDICAL SCIENCE SYSTEMS INC
S-8, 1998-11-12
MEDICAL LABORATORIES
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<PAGE>   1
       As filed with the Securities and Exchange Commission on November 12, 1998

                                               REGISTRATION NO. 333-____________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                           --------------------------

                                    FORM S-8

             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                              -------------------

                          MEDICAL SCIENCE SYSTEMS, INC.
             (Exact name of registrant as specified in its charter)


<TABLE>
         <S>                                                                 <C>       
                          TEXAS                                                  94-3123681
             (State or other jurisdiction of                                  (I.R.S. Employer
              incorporation or organization)                                 Identification No.)

               100 N.E. LOOP 410, SUITE 820                                      78216-4749
                    SAN ANTONIO, TEXAS                                           (Zip Code)
         (Address of Principal Executive Offices)
</TABLE>

                          EMPLOYEE STOCK PURCHASE PLAN
                            (Full title of the Plans)

                                U. SPENCER ALLEN
                             CHIEF FINANCIAL OFFICER
                          MEDICAL SCIENCE SYSTEMS, INC.
                          100 N.E. LOOP 410, SUITE 820
                            SAN ANTONIO, TEXAS 78216
                     (Name and address of agent for service)

                                 (210) 349-6400
          (Telephone number, including area code, of agent for service)

                              -------------------

                                  With Copy to:

                           FULBRIGHT & JAWORSKI L.L.P.
                             300 CONVENT, SUITE 2200
                            SAN ANTONIO, TEXAS 78205
                                 (210) 224-5575
                       ATTENTION: PHILLIP M. RENFRO, ESQ.

                              -------------------

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
================================================================================================================
                                                      PROPOSED           PROPOSED MAXIMUM
  TITLE OF SECURITIES         AMOUNT TO           MAXIMUM OFFERING      AGGREGATE OFFERING          AMOUNT OF
   TO BE REGISTERED         BE REGISTERED        PRICE PER UNIT(1)           PRICE(1)           REGISTRATION FEE
- ----------------------------------------------------------------------------------------------------------------
<S>                          <C>                 <C>                    <C>                     <C>     
     Common Stock,
     no par value            500,000(2)               $ 1.813               $ 906,500               $ 267.42

- ----------------------------------------------------------------------------------------------------------------

         Total                 500,000                   -                  $ 906,500               $ 267.42
================================================================================================================
</TABLE>

(1)      Pursuant to Rule 457(c), the maximum offering price per security and
         maximum aggregate offering price of the Common Stock have been
         calculated on the basis of the average of the high and low sale prices
         of the Common Stock as reported in the NASDAQ SmallCap Market System on
         November 5, 1998.

(2)      Pursuant to Rule 416(a), this Registration Statement shall also cover
         any additional shares of Common Stock which become issuable by reason
         of any stock dividend, stock split, recapitalization or other similar
         transactions effected without the receipt of consideration which
         results in an increase in the number of the outstanding shares of
         Common Stock.

================================================================================

                                       -1-

<PAGE>   2



                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.           INCORPORATION OF DOCUMENTS BY REFERENCE

                  The following documents are hereby incorporated by reference
in this Registration Statement:

                  1. The Annual Report on Form 10-KSB of Medical Science
Systems, Inc., a Texas corporation (the "Registrant"), for the year ended
December 31, 1997;

                  2. The Registrant's Quarterly Reports on Form 10-QSB for the
quarter ended March 31, and June 30, 1998;

                  3. The Registrant's Current Report on Form 8-K filed November
2, 1998; and

                  4. The description of the Registrant's Common Stock, no par
value, set forth under the caption "Description of Capital Stock" in the
prospectus that is included in the Registrant's Registration Statement on Form
SB-2 (File No. 333-37441), is hereby incorporated herein by reference.

                  All documents filed by the Registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the filing hereof
and prior to the filing of a post-effective amendment which indicates that all
securities offered have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference in this
Registration Statement and to be a part hereof from the date of filing such
documents.

                  For purposes of this Registration Statement, any document or
any statement contained in a document incorporated or deemed to be incorporated
herein by reference shall be deemed to be modified or superseded to the extent
that a subsequently filed document or a statement contained herein or in any
other subsequently filed document which also is or is deemed to be incorporated
herein by reference modifies or supersedes such document or such statement in
such document. Any statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Registration
Statement.

ITEM 4.           DESCRIPTION OF SECURITIES

                  Not Applicable.

ITEM 5.           INTERESTS OF NAMED EXPERTS AND COUNSEL

                  Not Applicable.



                                       -2-

<PAGE>   3



ITEM 6.           INDEMNIFICATION OF DIRECTORS AND OFFICERS

                  Article 2.02-1 of the Texas Business Corporation Act provides
that any director or officer of a Texas corporation may be indemnified against
judgments, penalties, fines, settlements and reasonable expenses actually
incurred by him in connection with or in defending any action, suit or
proceeding in which he is a party by reason of his position. With respect to any
proceeding arising from actions taken in his official capacity, as a director or
officer, he may be indemnified so long as it shall be determined that he
conducted himself in good faith and that he reasonably believed that such
conduct was in the corporation's best interests. In cases not concerning conduct
in his official capacity as a director or officer, a director may be indemnified
as long as he reasonably believed that his conduct was not opposed to the
corporation's best interests. In the case of any criminal proceeding, a director
or officer may be indemnified if he had no reasonable cause to believe his
conduct was unlawful. If a director or officer is wholly successful, on the
merits or otherwise, in connection with such a proceeding, such indemnification
is mandatory.

               The Company's Amended and Restated Articles of Incorporation and
Bylaws provide for indemnification of its present and former directors and
officers. The Company's Bylaws further provide for indemnification of officers
and directors against reasonable expenses actually incurred in connection with
the defense of any such action, suit or proceeding in advance of the final
disposition of the proceeding.

               The Amended and Restated Articles of Incorporation of the Company
contain a provision that limits the liability of the Company's directors as
permitted under Texas law. The provision eliminates the liability of a director
to the Company or its shareholders for monetary damages for an act or omission
in the director's capacity as a director. The provision does not affect the
liability of a director for (i) breach of the director's duty of loyalty to the
Company or its shareholders, (ii) an act or omission not in good faith that
constitutes a breach of duty of the director to the Company, or that involves
intentional misconduct or a knowing violation of law, (iii) a transaction from
which the director received an improper benefit, whether or not the benefit
resulted from an action taken within the scope of the director's office, or (iv)
an act or omission for which the liability of a director is expressly provided
by an applicable statute. In addition, the limitation of liability of directors
applies only to claims against a director arising out of his or her role as a
director and not, if he or she is also an officer his or her role as an officer
and does not limit a director's liability under any other law, such as federal
securities law.

ITEM 7.           EXEMPTION FROM REGISTRATION CLAIMED

                  Not applicable.

ITEM 8.           EXHIBITS

                   3.1       Amended and Restated Articles of Incorporation.*

                   3.2       Articles of Amendment to the Amended and Restated
                             Articles of Incorporation.*

                   3.3       Amended and Restated Bylaws of the Company.*


                                       -3-

<PAGE>   4



                   3.4       Amendment to the Amended and Restated Bylaws.*

                   4.1       Form of Stock Certificate.*

                   4.2       Form of Representative's Warrant.*

                   4.3       Form of Subordinated Promissory Note.*

                   4.4       Form of Security Agreement.*

                   4.5       Form of Warrant Agreement.*

                   4.6       Form of Warrant Certificate.*

                   5.1       Opinion of Fulbright & Jaworski L.L.P.

                  10.1       Medical Science Systems, Inc. Employee Stock
                             Purchase Plan.

                  23.1       Consent of Fulbright & Jaworski L.L.P. (included in
                             Exhibit 5.1).

                  23.2       Consent of Singer Lewak Greenbaum & Goldstein LLP.

                  24.1       Powers of Attorney from the members of the Board of
                             Directors of the Registrant (contained on signature
                             page).

- -------------------
*    Previously filed with the Commission as Exhibits to, and incorporated
     herein by reference from, the Company's Registration Statement filed on
     Form SB-2, File No. 333-37441.


ITEM 9.  UNDERTAKINGS

                The undersigned Registrant hereby undertakes:

                (1) To file, during any period in which offers or sales are
being made, a post-effective amendment to this Registration Statement:

                         (i)      To include any prospectus required by Section
                10(a)(3) of the Securities Act of 1933, as amended (the
                "Securities Act");

                         (ii) To reflect in the prospectus any facts or events
                arising after the effective date of this Registration Statement
                (or the most recent post-effective amendment hereof) which,
                individually or in the aggregate, represent a fundamental change
                in the information set forth in this Registration Statement; and


                                       -4-

<PAGE>   5



                         (iii) To include any material information with respect
                to the plan of distribution not previously disclosed in this
                Registration Statement or any material change to such
                information in this Registration Statement;

Provided, however, that paragraphs (i) and (ii) above do not apply if the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the Registrant pursuant to
Section 13 or Section 15(d) of the Exchange Act, that are incorporated by
reference in this Registration Statement.

                (2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered herein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

                (3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

                The undersigned Registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in this Registration Statement
shall be deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be deemed
to be the initial bona fide offering thereof.

                Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.


                                       -5-

<PAGE>   6



                                   SIGNATURES

                Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Antonio, State of Texas, on November 9, 1998.

                MEDICAL SCIENCE SYSTEMS, INC.


                By:      /s/    U. Spencer Allen
                   ------------------------------------------------------------
                         U. Spencer Allen
                         Chief Financial Officer



                                       -6-

<PAGE>   7



                                POWER OF ATTORNEY


                  KNOW ALL MEN BY THESE PRESENTS, that each individual whose
signature appears below constitutes and appoints Paul J. White and U. Spencer
Allen, or either of them, his true and lawful attorneys-in-fact and agents, with
full power of substitution and resubstitution, severally, for him and in his
name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement, and to
file the same and all exhibits thereto, and all documents in connection
therewith, with the Securities and Exchange Commission, granting said
attorney-in-fact and agent, and each of them, full power and authority to do and
perform each and every act and thing requisite and necessary to be done in and
about the premises, as fully to all intents and purposes as he might or could do
in person, hereby ratifying and confirming all that said attorney-in-fact and
agent or either of them, or their or his substitute or substitutes, may lawfully
do or cause to be done by virtue hereof.

                  Pursuant to the requirements of the Securities Act, this
registration statement has been signed by the following persons in the
capacities and on the dates indicated.


<TABLE>
<CAPTION>
SIGNATURE                                   TITLE                                DATE
- ---------                                   -----                                ----
<S>                                         <C>                                  <C>
/s/ Paul J. White                           President, Chief Executive           November 9, 1998
- ------------------------------------        Officer and Director         
Paul J. White                               (principal executive officer)
                                            

/s/ U. Spencer Allen                        Chief Financial Officer              November 9, 1998
- ------------------------------------        and Treasurer           
U. Spencer Allen                            (principal financial and
                                            accounting officer)     
                                            

/s/ Kenneth S. Kornman                      Director                             November 9, 1998
- ------------------------------------
Kenneth S. Kornman


/s/ Michael G. Newman                       Director                             November 9, 1998
- ------------------------------------
Michael G. Newman


/s/ Thomas A. Moore                         Director                             November 9, 1998
- ------------------------------------
Thomas A. Moore


/s/ Ronald L. LaRosa                        Director                             November 9, 1998
- ------------------------------------
Ronald L. LaRosa
</TABLE>



                                       -7-

<PAGE>   8


INDEX TO EXHIBITS

<TABLE>
<CAPTION>
Exhibit
Number            Description of Exhibits
- -------           -----------------------
<S>               <C>
    3.1           Amended and Restated Articles of Incorporation.*

    3.2           Articles of Amendment to the Amended and Restated Articles of Incorporation.*

    3.3           Amended and Restated Bylaws of the Company.*

    3.4           Amendment to the Amended and Restated Bylaws.*

    4.1           Form of Stock Certificate.*

    4.2           Form of Representative's Warrant.*

    4.3           Form of Subordinated Promissory Note.*

    4.4           Form of Security Agreement.*

    4.5           Form of Warrant Agreement.*

    4.6           Form of Warrant Certificate.*

    5.1           Opinion of Fulbright & Jaworski L.L.P.

   10.1           Medical Science Systems, Inc. Employee Stock Purchase Plan.

   23.1           Consent of Fulbright & Jaworski L.L.P. (included in Exhibit 5.1).

   23.2           Consent of Singer Lewak Greenbaum & Goldstein LLP.

   24.1           Powers of Attorney from the members of the Board of Directors of the Registrant
                  (contained on signature page).
</TABLE>

- ------------

*    Previously filed with the Commission as Exhibits to, and incorporated
     herein by reference from, the Company's Registration Statement filed on
     Form SB-2, File No. 333-37441.

<PAGE>   1
                                                                     EXHIBIT 5.1

                    [FULBRIGHT & JAWORSKI L.L.P. LETTERHEAD]


November 9, 1998



Medical Science Systems, Inc.
100 N.E. Loop 410, Suite 820
San Antonio, Texas  78216-4749

Gentlemen:

              We have acted as counsel for Medical Science Systems, Inc., a
Texas corporation (the "Company"), in connection with the authorization of
500,000 shares (the "Shares") of Common Stock, no par value ("Common Stock"), of
the Company to be issued pursuant to the Medical Science Systems, Inc.'s
Employee Stock Purchase Plan (the "Plan").

              In connection therewith, we have examined, among other things, the
Plan, the Articles of Incorporation and Bylaws of the Company and the corporate
proceedings with respect to the issuance of the Shares and such other corporate
documents as we have deemed appropriate.

              Based on the foregoing, and having due regard for such legal
considerations as we have deemed relevant, we are of the opinion that the Shares
to be issued by the Company pursuant to the terms of the Plan have been duly
authorized by all requisite corporate action and, when issued in accordance with
the terms thereof, will be validly issued, fully paid and nonassessable.

              We hereby consent to the filing of this opinion as an exhibit to
the Registration Statement and to the use of our names in the Registration
Statement.

              The opinions expressed herein are limited exclusively to the laws
of the State of Texas and the federal securities law of the United States of
America.

              The opinions expressed herein are for your sole benefit and may be
relied upon only by you.

                                                Very truly yours,


                                                /s/ Fulbright & Jaworski L.L.P.



<PAGE>   1
                                                                    EXHIBIT 10.1



                          MEDICAL SCIENCE SYSTEMS, INC.

                          EMPLOYEE STOCK PURCHASE PLAN




<PAGE>   2



                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                 SECTION
<S>      <C>                                                                      <C> 
ARTICLE I - PURPOSE, COMMITMENT AND INTENT

         Purpose.................................................................  1.1
         Share Commitment........................................................  1.2
         Intent..................................................................  1.3
         Shareholder Approval....................................................  1.4
                                                                                   
                                                                                   
ARTICLE II - DEFINITIONS                                                           
                                                                                   
         Affiliate...............................................................  2.1
         Beneficiary.............................................................  2.2
         Board of Directors......................................................  2.3
         Code....................................................................  2.4
         Committee...............................................................  2.5
         Company.................................................................  2.6
         Compensation............................................................  2.7
         Employee................................................................  2.8
         Employer................................................................  2.9
         Exercise Date........................................................... 2.10
         Fair Market Value....................................................... 2.11
         Five Percent Owner...................................................... 2.12
         Grant Date.............................................................. 2.13
         Offering Period......................................................... 2.14
         Option.................................................................. 2.15
         Option Price............................................................ 2.16
         Participant............................................................. 2.17
         Plan.................................................................... 2.18
         Shares.................................................................. 2.19
         Stock................................................................... 2.20
         Trading Day............................................................. 2.21
                                                                                   
                                                                                   
ARTICLE III - ELIGIBILITY                                                          
                                                                                   
         General Requirements....................................................  3.1
         Limitations Upon Participation..........................................  3.2
                                                                                   
                                                                                   
ARTICLE IV - PARTICIPATION                                                         

         Grant of Option.........................................................  4.1
</TABLE>

                                       -i-

<PAGE>   3


<TABLE>
<S>      <C>                                                                      <C> 
         Payroll Deduction.......................................................  4.2
         Payroll Deductions Continuing...........................................  4.3
         Right to Stop Payroll Deductions........................................  4.4
         Accounting for Funds....................................................  4.5
         Employer's Use of Funds.................................................  4.6
                                                                                   
                                                                                   
ARTICLE V - IN SERVICE WITHDRAWAL, TERMINATION OR DEATH                            
                                                                                   
         In Service Withdrawal...................................................  5.1
         Termination of Employment for any Reason Other Than Death...............  5.2
         Death...................................................................  5.3
                                                                                   
                                                                                   
ARTICLE VI - EXERCISE OF OPTION                                                    
                                                                                   
         Purchase of Stock.......................................................  6.1
         Accounting for Stock....................................................  6.2
         Issuance of Shares......................................................  6.3
                                                                                   
                                                                                   
ARTICLE VII - ADMINISTRATION                                                       
                                                                                   
         Appointment, Term of Service & Removal..................................  7.1
         Powers..................................................................  7.2
         Quorum and Majority Action..............................................  7.3
         Standard of Judicial Review of Committee Actions........................  7.4
                                                                                   
                                                                                   
ARTICLE VIII - ADOPTION OF PLAN BY OTHER EMPLOYERS                                 
                                                                                   
         Adoption Procedure......................................................  8.1
         No Joint Venture Implied................................................  8.2
                                                                                   
                                                                                   
ARTICLE IX - TERMINATION AND AMENDMENT OF THE PLAN                                 
                                                                                   
         Termination.............................................................  9.1
         Amendment...............................................................  9.2


ARTICLE X - MISCELLANEOUS

         Designation of Beneficiary.............................................. 10.1
         Plan Not An Employment Contract......................................... 10.2
         All Participants' Rights Are Equal...................................... 10.3
</TABLE>

                                      -ii-

<PAGE>   4



<TABLE>
         <S>                                                                      <C> 
         Options Are Not Transferable...........................................  10.4
         Voting of Stock........................................................  10.5
         No Rights of Stockholder...............................................  10.6
         Governmental Regulations...............................................  10.7
         Notices................................................................  10.8
         Indemnification of Committee...........................................  10.9
         Tax Withholding........................................................ 10.10
         Gender and Number...................................................... 10.11
         Severability........................................................... 10.12
         Governing Law; Parties to Legal Actions................................ 10.13
</TABLE>

                                      -iii-

<PAGE>   5



                                    ARTICLE I

                         PURPOSE, COMMITMENT AND INTENT


         1.1 PURPOSE. The purpose of this Plan is to provide Employees of the
Company and its Affiliates that adopt the Plan with an opportunity to purchase
Stock of the Company through quarterly offerings of options at a discount on the
first day of each calendar quarter and thus develop a stronger incentive to work
for the continued success of the Company and its Affiliates. Therefore, this
Plan is available to all Employees of every Employer upon their fulfilling the
eligibility requirements of Section 3.1. It is sponsored by the Company. Any
Affiliate may adopt it with the approval of the Committee by fulfilling the
requirements of Section 8.1.

         1.2 SHARE COMMITMENT. The aggregate number of Shares authorized to be
sold pursuant to Options granted under this Plan is 500,000, subject to
adjustment as provided in this Section. In computing the number of Shares
available for grant, any Shares relating to Options which are granted, but which
subsequently lapse, are cancelled or are otherwise not exercised by the final
date for exercise, shall be available for future grants of Options.

         In the event of any stock dividend, split-up, recapitalization, merger,
consolidation, combination or exchange of shares of Stock, or the like, as a
result of which shares shall be issued in respect of the outstanding Shares, or
the Shares shall be changed into the same or a different number of the same or
another class of stock, the total number of shares of Stock authorized to be
committed to this Plan, the number of Shares subject to each outstanding Option,
the Option Price applicable to each Option, and/or the consideration to be
received upon exercise of each Option shall be appropriately adjusted by the
Committee. In addition, the Committee shall, in its sole discretion, have
authority to provide, in appropriate cases, for (a) acceleration of the Exercise
Date of outstanding Options or (b) the conversion of outstanding Options into
cash or other property to be received in certain of the transactions specified
in this paragraph above upon the completion of the transaction.

         1.3 INTENT. It is the intention of the Company to have the Plan qualify
as an "employee stock purchase plan" under section 423 of the Code. Therefore,
the provisions of the Plan are to be construed to govern participation in a
manner consistent with the requirements of section 423 of the Code.

         1.4 SHAREHOLDER APPROVAL. To be effective, this Plan must be approved
by the stockholders of each of the Employers within 12 months after the Plan is
adopted. The approval of stockholders must comply with all applicable provisions
of the corporate charter, bylaws and applicable laws of the jurisdiction
prescribing the method and degree of stockholder approval required for the
issuance of corporate stock or options.

                                       I-1

<PAGE>   6



                                   ARTICLE II

                                   DEFINITIONS


         The words and phrases defined in this Article shall have the meaning
set out in these definitions throughout this Plan, unless the context in which
any word or phrase appears reasonably requires a broader, narrower, or different
meaning.

         2.1 "AFFILIATE" means any parent corporation and any subsidiary
corporation. The term "parent corporation" means any corporation (other than the
Company) in an unbroken chain of corporations ending with the Company if, at the
time of the action or transaction, each of the corporations (other than the
Company) owns stock possessing 50% or more of the total combined voting power of
all classes of stock in one of the other corporations in the chain. The term
"subsidiary corporation" means any corporation (other than the Company) in an
unbroken chain of corporations beginning with the Company if, at the time of the
granting of the Option, each of the corporations other than the last corporation
in the unbroken chain owns stock possessing 50% or more of the total combined
voting power of all classes of stock in one of the other corporations in the
chain.

         2.2 "BENEFICIARY" means the person who is entitled to receive amounts
under the Plan upon the death of a Participant.

         2.3 "BOARD OF DIRECTORS" means the board of directors of the Company.

         2.4 "CODE" means the Internal Revenue Code of 1986, as amended from
time to time.

         2.5 "COMMITTEE" means the committee appointed by the Board of
Directors.

         2.6 "COMPANY" means Medical Science Systems, Inc., a Texas corporation.

         2.7 "COMPENSATION" means the base cash compensation paid by the
Employer to the Participant which is required to be reported as wages on the
Participant's Form W-2, including such additional amounts which are not
includable in gross income by reason of Sections 125, 402(e) or 402(h)(1)(B) of
the Code, and excluding any bonuses, overtime pay, expense allowances and other
irregular payments (except commissions).

         2.8 "EMPLOYEE" means any person who is a common-law employee of the
Company or any Affiliate. Provided, however, the term "Employee" shall not
include an employee whose customary employment is twenty (20) hours or less per
week.

         2.9 "EMPLOYER" means the Company and all Affiliates that have adopted
the Plan.

         2.10 "EXERCISE DATE" means the last day of each Offering Period, which
is the day that all Options that eligible Employees have elected to exercise are
to be exercised.



                                      II-1

<PAGE>   7



         2.11 "FAIR MARKET VALUE" of the Stock as of any date means the average
of the high and low sale prices of the Stock on a given date (or if there was no
sale on that date, the next preceding date on which there was a sale) on the
principal securities exchange on which the Stock is listed.

         2.12 "FIVE PERCENT OWNER" means an owner of five percent or more of the
total combined voting power of all classes of stock of the Company or any
Affiliate. An individual is considered to own any stock that is owned directly
or indirectly by or for his brothers and sisters (whether by whole or
half-blood), spouse, ancestors and lineal descendants. Stock owned, directly or
indirectly, by or for a corporation, partnership, estate or trust is considered
as owned proportionately by or for its shareholders, partners, or beneficiaries.
An individual is considered to own stock that he may purchase under outstanding
options. The determination of the percentage of the total combined voting power
of all classes of stock of the Company or any Affiliate that is owned by an
individual is made by comparing the voting power or value of the shares owned
(or treated as owned) by the individual to the aggregate voting power of all
shares actually issued and outstanding immediately after the grant of the option
to the individual. The aggregate voting power or value of all shares actually
issued and outstanding immediately after the grant of the option does not
include the voting power or value of treasury shares or shares authorized for
issue under outstanding options held by the individual or any other person.

         2.13 "GRANT DATE" means the first day of each Offering Period, which is
the day the Committee grants all eligible Employees an Option under this Plan.

         2.14 "OFFERING PERIOD" means the period beginning on the Grant Date and
ending on the Exercise Date. The first Offering Period under the Plan shall
commence on October 14, 1998, and shall end on the last Trading Day on or before
December 31, 1998. Thereafter, the Offering Period shall commence on the first
day of each calendar quarter and shall end on the last Trading Day on or before
the last day of each calendar quarter, unless the Committee specifies another
Offering Period (which may not exceed 27 months).

         2.15 "OPTION" means an option granted under this Plan to purchase
shares of Stock at the Option Price on the Exercise Date.

         2.16 "OPTION PRICE" means the price to be paid for each Share upon
exercise of an Option, which shall be the lesser of 85% of the Fair Market Value
of a Share on the Exercise Date or Grant Date.

         2.17 "PARTICIPANT" means a person who is eligible to be granted an
Option under this Plan and who elects to have payroll deductions withheld under
the Plan for the purpose of exercising that Option on the Exercise Date.

         2.18 "PLAN" means Medical Science Systems, Inc. Employee Stock Purchase
Plan, as set out in this document and as it may be amended from time to time.

         2.19     "SHARES" means shares of Stock.

         2.20     "STOCK" means the Company's common stock, no par value.


                                      II-2

<PAGE>   8



         2.21 "TRADING DAY" shall mean a day on which the principal securities
exchange on which the Stock is listed is open for trading.

                                      II-3

<PAGE>   9



                                   ARTICLE III

                                   ELIGIBILITY


         3.1 GENERAL REQUIREMENTS. Subject to Section 3.2, each Employee of each
Employer is eligible to participate in the Plan for a given Offering Period if,
prior to the Grant Date, he is in the employ of an Employer on the Grant Date
and he completes a subscription form authorizing payroll deductions and files it
with the Employer's payroll office prior to the Grant Date.

         3.2 LIMITATIONS UPON PARTICIPATION. No Employee shall be granted an
Option to the extent that the Option would:

                  (a) cause the Employee to be a Five Percent Owner immediately
         after the grant;

                  (b) permit the Employee to purchase Stock under all employee
         stock purchase plans, as defined in section 423 of the Code, of the
         Company and all Affiliates at a rate which exceeds $25,000 in Fair
         Market Value of the Stock (determined at the time the Option is
         granted) for each calendar year in which the option granted to the
         Employee is outstanding at any time as provided in sections 423 and 424
         of the Code; or

                  (c) permit the Employee to purchase Stock in excess of the
         number of Shares determined under Section 4.1.



                                      III-1

<PAGE>   10



                                   ARTICLE IV

                                  PARTICIPATION


         4.1 GRANT OF OPTION. Effective as of the Grant Date of each Offering
Period, the Committee shall grant an Option to each Participant which shall be
exercisable on the Exercise Date only through funds accumulated by the Employee
through payroll deductions made during the Offering Period together with any
funds remaining in the Participant's payroll deduction account at the beginning
of the Offering Period. The Option shall be for that number of whole Shares that
may be purchased by the amount in the Participant's payroll deduction account on
the Exercise Date at the Option Price.

         4.2 PAYROLL DEDUCTION. For an Employee to participate during a given
Offering Period, he must complete a payroll deduction form and file it with his
Employer no earlier than 60 days prior to the beginning of the Offering Period
and he must be employed by an Employer on the day before the start of the
Offering Period. The payroll deduction form shall permit a Participant to elect
to have withheld from his Compensation a specified percentage or dollar amount
each pay period during the Offering Period; provided, however, no more than
twenty percent (20%) of a Participant's Compensation may be withheld under the
Plan on any pay date, and provided further that the Committee, acting in its
discretion in any uniform and nondiscriminatory manner, may establish a minimum
required amount or percentage of Compensation which must be withheld during the
Offering Period. Payroll deductions shall normally begin with the first pay date
during the Offering Period. However, if a Participant files his subscription
agreement with the Employer less than ten days before the Grant Date, his
payroll deductions shall begin with the second pay date during the Offering
Period. Payroll deductions shall continue through the last pay date prior to the
Exercise Date. A Participant may not make additional payments to his Plan
account.

         4.3 PAYROLL DEDUCTIONS CONTINUING. A Participant's payroll deduction
election shall remain in effect for all ensuing Offering Periods until changed
by him by filing an appropriate amended payroll deduction form no earlier than
60 days prior to the commencement of the Offering Period for which it is to be
effective.

         4.4 RIGHT TO STOP PAYROLL DEDUCTIONS. A Participant shall have the
right to discontinue payroll deductions by filing subscription cancellation form
with the Company. The payroll deduction cancellation shall become effective with
the first full pay date following ten business days after the Company's receipt
of the subscription cancellation agreement unless the Company elects to process
a given cancellation in participation more quickly. With the exception of a
complete discontinuance of payroll deductions, a Participant may not change his
participation rate during an Offering Period.

         4.5 ACCOUNTING FOR FUNDS. As of each payroll deduction period, the
Employer shall cause to be credited to the Participant's payroll deduction
account in a ledger established for that purpose the funds withheld from and
attributable to the Employee's cash compensation for that period. No interest
shall be credited to the Participant's payroll deduction account at any time.
The obligation of the Employer to the Participant for this account shall be a
general corporate obligation


                                      IV-1

<PAGE>   11



and shall not be funded through a trust nor secured by any assets which would
cause the Participant to be other than a general creditor of the Employer.

         4.6 EMPLOYER'S USE OF FUNDS. All payroll deductions received or held by
an Employer may be used by the Employer for any corporate purpose, and the
Employer shall not be obligated to segregate such payroll deductions.


                                      IV-2

<PAGE>   12



                                    ARTICLE V

                   IN SERVICE WITHDRAWAL, TERMINATION OR DEATH


         5.1 IN SERVICE WITHDRAWAL. A Participant may, at any time on or before
15 days prior to the Exercise Date, or such other date as shall be selected by
the Committee from time to time, elect to withdraw all or a portion of the funds
and Stock then credited to his Plan account by giving notice in accordance with
the rules established by the Committee. The amount elected to be withdrawn by
the Participant shall be paid to him as soon as administratively feasible. Any
election by a Participant to withdraw all or a portion of his cash balance under
the Plan terminates his right to exercise his Option on the Exercise Date and
his entitlement to elect any further payroll deductions for the then-current
Offering Period. If the Participant wishes to participate in any future Offering
Period, he must file a new payroll deduction election within the time frame
required by the Committee for participation for that Offering Period.

         5.2 TERMINATION OF EMPLOYMENT FOR ANY REASON OTHER THAN DEATH. If a
Participant's employment is terminated for any reason other than death prior to
the Exercise Date, the Option granted to the Participant for that Offering
Period shall lapse. The Participant's funds and Stock then credited to his Plan
Account shall be returned to him as soon as administratively feasible.

         5.3 DEATH. If a Participant dies before the Exercise Date, the Option
granted to the Participant for that Offering Period shall lapse. The
Participant's Shares and funds then credited to his Plan account shall be
delivered to his Beneficiary (or to his estate if he has no Beneficiary) as soon
as administratively feasible. If the Participant dies after the Exercise Date
but prior to the delivery of his certificate, the Stock and funds credited to
the Participant's account shall be delivered to his Beneficiary (or to his
estate if he has no Beneficiary). If there is no Beneficiary, the Stock and
funds credited to a Participant's account may be held in the Participant's Plan
account until the representative of the estate has been appointed and provides
such evidence as may be required by the Committee.



                                       V-1

<PAGE>   13



                                   ARTICLE VI

                               EXERCISE OF OPTION


         6.1 PURCHASE OF STOCK. Subject to Section 3.2, on the Exercise Date of
each Offering Period, each Participant's payroll deduction account shall be used
to purchase the maximum number of whole shares of Stock that can be purchased at
the Option Price for that Offering Period. Any funds remaining in a
Participant's payroll deduction account after the exercise of his Option for the
Offering Period shall remain in the Participant's account to be used in the
ensuing Offering Period, together with new payroll deductions, if any, for that
Offering Period to exercise the next succeeding Option which is to be exercised.
If in any Offering Period the total number of shares of Stock to be purchased by
all Participants exceeds the number of shares of Stock committed to the Plan,
then each Participant shall be entitled to purchase only his pro rata portion of
the shares of Stock remaining available under the Plan based on the balances in
each Participant's payroll deduction account as of the Exercise Date. No
fractional shares of Stock shall be purchased under this Plan. After the
purchase of all shares of Stock available on the Exercise Date, all Options
granted for the Offering Period to the extent not used are terminated because no
Option shall remain exercisable after one year from the date of Grant.

         6.2 ACCOUNTING FOR STOCK. After the Exercise Date of each Offering
Period, a report shall be given to each Participant stating the amount of his
payroll deduction account, the number of shares of Stock purchased and the
Option Price.

         6.3 ISSUANCE OF SHARES. As soon as administratively feasible after the
end of the Offering Period, the Committee shall advise the appropriate officer
of the Company that the terms of the Plan have been complied with and that it is
appropriate for the officer to cause to be issued the shares of Stock upon which
Options have been exercised under the Plan. The Committee may determine in its
discretion the manner of delivery of the shares of Stock purchased under the
Plan, which may be by electronic account entry into new or existing accounts,
delivery of Stock certificates or any other means as the Committee, in its
discretion, deems appropriate. The Committee may, in its discretion, hold the
Stock certificate for any shares of Stock or cause it to be legended in order to
comply with the securities laws of the applicable jurisdiction.



                                      VI-1

<PAGE>   14



                                   ARTICLE VII

                                 ADMINISTRATION


         7.1 APPOINTMENT, TERM OF SERVICE & REMOVAL. The Board of Directors
shall appoint a Committee to administer this Plan. The members shall serve until
their resignation, death or removal. Any member may resign at any time by
mailing a written resignation to the Board of Directors. Any member may be
removed by the Board of Directors, with or without cause. Vacancies may be
filled by the Board of Directors from time to time.

         7.2 POWERS. The Committee has the exclusive responsibility for the
general administration of the Plan, and has all powers necessary to accomplish
that purpose, including but not limited to the following rights, powers, and
authorities:

                  (a) to make rules for administering the Plan so long as they
         are not inconsistent with the terms of the Plan;

                  (b) to construe all provisions of the Plan;

                  (c) to correct any defect, supply any omission, or reconcile
         any inconsistency which may appear in the Plan;

                  (d) to select, employ, and compensate at any time any
         consultants, accountants, attorneys, and other agents the Committee
         believes necessary or advisable for the proper administration of the
         Plan;

                  (e) to determine all questions relating to eligibility, Fair
         Market Value, Option Price and all other matters relating to benefits
         or Participants' entitlement to benefits;

                  (f) to determine all controversies relating to the
         administration of the Plan, including but not limited to any
         differences of opinion arising between an Employer and a Participant,
         and any questions it believes advisable for the proper administration
         of the Plan; and

                  (g) to delegate any clerical or recordation duties of the
         Committee as the Committee believes is advisable to properly administer
         the Plan.

         7.3 QUORUM AND MAJORITY ACTION. A majority of the Committee constitutes
a quorum for the transaction of business. The vote of a majority of the members
present at any meeting shall decide any question brought before that meeting. In
addition, the Committee may decide any question by a vote, taken without a
meeting, of a majority of its members via telephone, computer, fax or any other
media of communication.


                                      VII-1

<PAGE>   15



         7.4 STANDARD OF JUDICIAL REVIEW OF COMMITTEE ACTIONS. The Committee has
full and absolute discretion in the exercise of each and every aspect of its
authority under the Plan. Notwithstanding anything to the contrary, any action
taken, or ruling or decision made by the Committee in the exercise of any of its
powers and authorities under the Plan shall be final and conclusive as to all
parties other than the Company, including without limitation all Participants
and their beneficiaries, regardless of whether the Committee or one or more of
its members may have an actual or potential conflict of interest with respect to
the subject matter of the action, ruling, or decision. No final action, ruling,
or decision of the Committee shall be subject to de novo review in any judicial
proceeding; and no final action, ruling, or decision of the Committee may be set
aside unless it is held to have been arbitrary and capricious by a final
judgment of a court having jurisdiction with respect to the issue.



                                      VII-2

<PAGE>   16



                                  ARTICLE VIII

                       ADOPTION OF PLAN BY OTHER EMPLOYERS


         8.1 ADOPTION PROCEDURE. With the approval of the Committee, any
Affiliate may adopt this Plan by:

                  (a) a certified resolution or consent of the board of
         directors of the adopting Affiliate or an executed adoption instrument
         (approved by the board of directors of the adopting Affiliate) agreeing
         to be bound as an Affiliate by all the terms, conditions and
         limitations of this Plan; and

                  (b) providing all information required by the Committee.

         8.2 NO JOINT VENTURE IMPLIED. The document which evidences the adoption
of the Plan by an Affiliate shall become a part of this Plan. However, neither
the adoption of this Plan by an Affiliate nor any act performed by it in
relation to this Plan shall create a joint venture or partnership relation
between it and the Company or any other Affiliate.


                                     VIII-1

<PAGE>   17



                                   ARTICLE IX

                      TERMINATION AND AMENDMENT OF THE PLAN


         9.1 TERMINATION. The Company may, by action of the Board of Directors,
terminate the Plan at any time and for any reason. The Plan shall automatically
terminate upon the purchase by Participants of all shares of Stock committed to
the Plan, unless the number of Shares committed to the Plan is increased by the
Board of Directors and approved by the shareholders of the Company. Upon
termination of the Plan, as soon as administratively feasible there shall be
refunded to each Participant the remaining funds in his payroll deduction
account, and there shall be forwarded to the Participants certificates for all
shares of Stock held under the Plan for the account of Participants. The
termination of this Plan shall not affect the current Options already
outstanding under the Plan to the extent there are Shares committed, unless the
Participants agree.

         9.2 AMENDMENT. The Board of Directors reserves the right to modify,
alter or amend the Plan at any time and from time to time to any extent that it
deems advisable, including, without limiting the generality of the foregoing,
any amendment deemed necessary to ensure compliance of the Plan with section 423
of the Code. The Board of Directors may suspend the operation of the Plan for
any period as it may deem advisable. However, no amendment or suspension shall
operate to reduce any amounts previously allocated to a Participant's payroll
deduction account, to reduce a Participant's rights with respect to shares of
Stock previously purchased and held on his behalf under the Plan nor to affect
the current Option a Participant already has outstanding under the Plan without
the Participant's agreement. Any amendment changing the aggregate number of
shares to be committed to the Plan, the class of employees eligible to receive
Options under the Plan or the description of the group of corporations eligible
to adopt this Plan must have stockholder approval as set forth in Section 1.4.


                                      IX-1

<PAGE>   18



                                    ARTICLE X

                                  MISCELLANEOUS


         10.1     DESIGNATION OF BENEFICIARY.

                           (a) A Participant may file a written designation of a
                  Beneficiary who is to receive any cash and Shares credited to
                  the Participant's account under the Plan. If a Participant is
                  married and the designated Beneficiary is not the
                  Participant's spouse, written spousal consent shall be
                  required for the designation to be effective.

                           (b) A Participant may change his designation of a
                  Beneficiary at any time by written notice. If a Participant
                  dies when he has not validly designated a Beneficiary under
                  the Plan, the Company shall deliver such Shares and cash to
                  the executor or administrator of the estate of the
                  Participant, or if no such executor or administrator has been
                  appointed (to the knowledge of the Company), the Company, in
                  its discretion, may deliver such Shares and cash to the spouse
                  or to any one or more dependents or relatives of the
                  Participant, or if no spouse, dependent or relative is known
                  to the Company, then to such other person as the Company may
                  designate.

         10.2 PLAN NOT AN EMPLOYMENT CONTRACT. The adoption and maintenance of
this Plan is not a contract between any Employer and its Employees which gives
any Employee the right to be retained in its employment. Likewise, it is not
intended to interfere with the rights of any Employer to discharge any Employee
at any time or to interfere with the Employee's right to terminate his
employment at any time.

         10.3 ALL PARTICIPANTS' RIGHTS ARE EQUAL. All Participants will have the
same rights and privileges under this Plan as required by section 423 of the
Code and Department of Treasury Regulation section 1.423-2(f).

         10.4 OPTIONS ARE NOT TRANSFERABLE. No Option granted a Participant
under this Plan is transferable by the Participant otherwise than by will or the
laws of descent and distribution, and must be exercisable, during his lifetime,
only by him. In the event any Participant attempts to violate the terms of this
Section, any Option held by the Participant shall be terminated by the Company
and, upon return to the Participant of the remaining funds in his payroll
deduction account, all of his rights under the Plan will terminate.

         10.5 VOTING OF STOCK. Shares of Stock held under the Plan for the
account of each Participant shall be voted by the holder of record of those
Shares in accordance with the Participant's instructions.


                                       X-1

<PAGE>   19


         10.6 NO RIGHTS OF STOCKHOLDER. No eligible Employee or Participant
shall by reason of participation in the Plan have any rights of a stockholder of
the Company until he acquires Shares of Stock as provided in this Plan.

         10.7 GOVERNMENTAL REGULATIONS. The obligation to sell or deliver the
shares of Stock under this Plan is subject to the approval of all governmental
authorities required in connection with the authorization, purchase, issuance or
sale of that Stock.

         10.8 NOTICES. All notices and other communication in connection with
the Plan shall be in the form specified by the Committee and shall be deemed to
have been duly given when sent to the Participant at his last known address or
to his designated personal representative or beneficiary, or to the Employer or
its designated representative, as the case may be.

         10.9 INDEMNIFICATION OF COMMITTEE. In addition to all other rights of
indemnification as they may have as directors or as members of the Committee,
the members of the Committee shall be indemnified by the Company against the
reasonable expenses, including attorneys' fees, actually and necessarily
incurred in connection with the defense of any action, suit or proceeding, or in
connection with any appeal, to which they or any of them may be a party by
reason of any action taken or failure to act under or in connection with the
Plan or any Option granted under the Plan, and against all amounts paid in
settlement (provided the settlement is approved by independent legal counsel
selected by the Company) or paid by them in satisfaction of a judgment in any
action, suit or proceeding, except in relation to matters as to which it is
adjudged in the action, suit or proceeding, that the Committee member is liable
for gross negligence or willful misconduct in the performance of his duties.

         10.10 TAX WITHHOLDING. At the time a Participant's Option is exercised
or at the time a Participant disposes of some or all of the Stock purchased
under the Plan, the Participant must make adequate provision for the Employer's
federal, state or other tax withholding obligations, if any, which arise upon
the exercise of the Option or the disposition of the Stock. At any time, the
Employer may, but shall not be obligated to, withhold from the Participant's
compensation the amount necessary for the Employer to meet applicable
withholding obligations.

         10.11 GENDER AND NUMBER. If the context requires it, words of one
gender when used in this Plan shall include the other genders, and words used in
the singular or plural shall include the other.

         10.12 SEVERABILITY. Each provision of this Plan may be severed. If any
provision is determined to be invalid or unenforceable, that determination shall
not affect the validity or enforceability of any other provision.

         10.13 GOVERNING LAW; PARTIES TO LEGAL ACTIONS. The provisions of this
Plan shall be construed, administered, and governed under the laws of the State
of Texas and, to the extent applicable, by the securities, tax, employment and
other laws of the United States.

                                      X-2

<PAGE>   1
                                                                    EXHIBIT 23.2



              CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS


We have issued our report dated March 13, 1998 accompanying the consolidated 
financial statements of Medical Science Systems, Inc. appearing in the 1997 
Annual Report of the Company to its shareholders on Form 10-KSB for the year 
ended December 31, 1997 which are incorporated by reference in this 
Registration Statement of the aforementioned report and to the use of our name 
as it appears under the caption "Experts."

/s/ SINGER LEWAK GREENBAUM & GOLDSTEIN LLP

SINGER LEWAK GREENBAUM & GOLDSTEIN LLP

Los Angeles, California
November 10, 1998


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