INTERNATIONAL ISOTOPES INC
S-8, 1999-02-03
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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    As filed with the Securities and Exchange Commission On January 29, 1999

                                                           Registration No. 333-

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                            ------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                           INTERNATIONAL ISOTOPES INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)

             Texas                                              74-2763837 
- ---------------------------------------                      -------------------
   (State or other jurisdiction of                                 (I.R.S.
Employer incorporation or organization)                      Identification No.)

          (Address and Telephone Number of Principal Executive Offices
                        and Principal Place of Business)
                            Ira Lon Morgan, Chairman
                             3100 Jim Christal Road
                               Denton, Texas 76207
                                 (940) 484-9492

            INTERNATIONAL ISOTOPES INC. 1997 LONG TERM INCENTIVE PLAN
                            (Full title of the Plan)
                             ----------------------
                               Dr. Ira Lon Morgan
                              Chairman of the Board
                               3100 Christal Road
                               Denton, Texas 76207
                     (Name and address of agent for service)
                                 (940) 484-9492
          (Telephone number, including area code, of agent for service)
                              ---------------------
                                    Copy to:
                                Curtis R. Ashmos
                            Locke Liddell & Sapp LLP
                             100 Congress, Suite 300
                               Austin, Texas 78701
                                 (512) 305-4716
                            ------------------------

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------
                                         Proposed         Proposed
     Title of                             Maximum          Maximum            
 Securities to be     Amount to be     Offering Price  Aggregate Offering      Amount of    
    Registered         Registered       Per Share (1)     Price (1)         Registration Fee
- -------------------------------------------------------------------------------------------
<S>                   <C>                 <C>              <C>                  <C>
Common Stock,         600,000 shares      $12.25           $7,350,000           $2,168.25
$.01 par value
- -------------------------------------------------------------------------------------------
</TABLE>

        (1) Estimated in accordance with Rule 457(h) under the Securities Act of
1933, as amended, (the "Act") solely for purposes of calculating the
registration fee, based on the closing sales price reported on the Nasdaq
SmallCap Market on January 27, 1999.


<PAGE>

                                     PART I
              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

        The information specified by Item 1 and Item 2 of Part I of Form S-8 is
omitted from this filing in accordance with provisions of Rule 428 under the
Securities Act of 1933 (the "Securities Act") and the introductory Note to Part
I of Form S-8.

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

        The documents set forth below are incorporated by reference in this
Registration Statement. All documents subsequently filed by International
Isotopes Inc. (the "Company") pursuant to Sections 13(a), 13(c), 14 and 15(d) of
the Securities Exchange Act of 1934 (the "Exchange Act"), prior to the filing of
a post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference in this Registration Statement and to be part
hereof from the date of filing of such documents.

        (1)    The Company's Annual Report on Form 10-KSB for the fiscal year
               ended December 31, 1997.

        (2)    All other reports filed pursuant to Section 13(a) or 15(d) of the
               Exchange Act since the end of the fiscal year covered by the
               Annual Report on Form 10-KSB described in (1) above.

        (3)    The description of the Common Stock that is contained in the
               Company's Registration Statement on Form 8-A dated August 1,
               1997, filed pursuant to Section 12 of the Exchange Act, and all
               amendments thereto and reports which have been filed for the
               purpose of updating such description.

Item 4.  Description of Securities.

         Not Applicable.

Item 5.  Interests of Named Experts and Counsel.

         Not Applicable.

                                      -2-


<PAGE>

Item 6.  Indemnification of Directors and Officers.

        Article 2.02-1 of the Texas Business Corporation Act (the "TBCA")
permits a corporation to indemnify certain persons, including officers and
directors and former officers and directors, and to purchase insurance with
respect to liability arising out of their capacity or status as officers and
directors.

        Article X of the Company's Restated Articles of Incorporation provides
as follows:

        The corporation shall indemnify any person who was, is, or is threatened
        to be made a named defendant or respondent in a proceeding (as
        hereinafter defined) because the person (a) is or was a director or
        officer of the corporation or (b) while a director or officer of the
        corporation, is or was serving at the request of the corporation as a
        director, officer, partner, venturer, proprietor, trustee, employee,
        agent, or similar functionary of another foreign or domestic
        corporation, partnership, joint venture, sole proprietorship, trust,
        employee benefit plan, or other enterprise, to the fullest extent that a
        corporation may grant indemnification to a person serving in such
        capacity under the Texas Business Corporation Act, as the same exists or
        may hereafter be amended. Such right shall be a contract right and as
        such shall run to the benefit of any director or officer who is elected
        and accepts the position of director or officer of the Corporation or
        elects to continue to serve as a director or officer of the Corporation
        while this Article X is in effect. Any repeal or amendment of this
        Article X shall be prospective only and shall not limit the rights of
        any such director or officer or the obligations of the corporation with
        respect to any claim arising from or related to the services of such
        director or officer in any of the foregoing capacities prior to any such
        repeal or amendment of this Article X and shall include the right to be
        paid or reimbursed by the corporation for all expenses incurred in
        defending any such proceeding in advance of its final disposition to the
        maximum extent permitted under the Texas Business Corporation Act, as
        the same exists or may hereafter be amended. If a claim for
        indemnification or advancement of expenses hereunder is not paid in full
        by the corporation within 90 days after a written claim has been
        received by the corporation, the claimant may at any time thereafter
        bring suit against the corporation to recover the unpaid amount of the
        claim and, if successful in whole or in part, the claimant shall be
        entitled to be paid also the expenses of prosecuting such claim. It
        shall be a defense to any such action that such indemnification or
        advancement of costs of defense is not permitted under the Texas
        Business Corporation Act, but the burden of proving such defense shall
        be on the corporation. Neither the failure of the corporation (including
        its Board of Directors or any committee thereof, special legal counsel,
        or shareholders) to have made its determination prior to the
        commencement of such action that indemnification of, or advancement of
        costs of defense to, the claimant is permissible in the circumstances

                                      -3-

<PAGE>

        nor an actual determination by the corporation (including its Board of
        Directors or any committee thereof, special legal counsel, or
        shareholders) that such indemnification or advancement is not
        permissible shall be a defense to the action or create a presumption
        that such indemnification or advancement is not permissible. In the
        event of the death of any person having a right of indemnification under
        the foregoing provisions, such right shall inure to the benefit of his
        heirs, executors, administrators, and personal representatives. The
        rights conferred above shall not be exclusive of any other right which
        any person may have or hereafter acquire under any statute, bylaw,
        resolution of shareholders or directors, agreement, or otherwise.

        The corporation may additionally indemnify any person covered by the
        grant of mandatory indemnification contained above to such further
        extent as is permitted by law and may indemnify any other person to the
        fullest extent permitted by law.

        To the extent permitted by then applicable law, the grant of mandatory
        indemnification to any person pursuant to this Article X shall extend to
        proceedings involving the negligence of such person.

        As used herein, the term "proceeding" means any threatened, pending, or
        completed action, suit, or proceeding, whether civil, criminal,
        administrative, arbitrative, or investigative, any appeal in such an
        action, suit, or proceeding, and any inquiry or investigation that could
        lead to such an action, suit, or proceeding.

        The Company has obtained liability insurance coverage for its officers
and directors which will entitle the Company to be reimbursed up to an aggregate
of $5 million for certain indemnity payments it may be required or permitted to
make to such persons with respect to actions arising out of the performance of
their duties.

Item 7.  Exemption from Registration Claimed.

         Not Applicable.

Item 8.  Exhibits.

         4.1    -     Specimen Stock Certificate of the Company (incorporated
                      by reference to the corresponding Exhibit Number in the
                      Company's Registration Statement on Form SB-2
                      (Registration No. 333-26269) filed with the Securities and
                      Exchange Commission on May 1, 1997.

         4.2    -     Articles of Incorporation of the Company (incorporated
                      by reference to Exhibit Number 3.1 in the Company's
                      Registration Statement on Form SB-2 (Registration No.
                      333-26269) filed with the Securities and Exchange
                      Commission on May 1, 1997.

                                      -4-

<PAGE>

         4.3    -     Bylaws of the  Company (incorporated by reference to 
                      Exhibit Number 3.2 in the Company's Registration
                      Statement on Form SB-2 ((Registration No. 333-26269)
                      filed with the Securities and Exchange Commission on
                      May 1, 1997.

         5.1    -     Opinion of Locke Liddell & Sapp LLP.

        23.1    -     Consent of KPMG LLP, Independent Accountants.

        23.2    -     Consent of Locke Liddell & Sapp LLP (included in its
                      opinion filed as Exhibit 5.1).

        24.1    -     Power of Attorney (included on the signature page of this
                      Registration Statement).

        99.1    -     International Isotopes Inc. 1997 Long Term Incentive Plan
                      (incorporated by reference to Exhibit 10.1 to Amendment 
                      No. 1 to the Company's Registration Statement on Form SB-2
                      (Registration No. 333-26269) previously filed with the
                      Securities and Exchange Commission)

Item 9. Undertakings.

        The Company herein undertakes:

        (1)    To file, during any period in which offers or sales are being
               made, a post-effective amendment to this Registration Statement:

               (i)    To include any prospectus required by Section 10(a)(3)
                      of the Securities Act;

               (ii)   To reflect in the prospectus any facts or events arising
                      after the effective date of this Registration Statement
                      (or the most recent post-effective amendment thereof)
                      which, individually or in the aggregate, represent a
                      fundamental change in the information set forth in this
                      Registration Statement;

               (iii)  To include any material information with respect to the
                      plan of distribution not previously disclosed in this
                      Registration Statement or any material change to such
                      information in the Registration Statement;

               Provided, however, that paragraphs (1) (i) and (1)(ii) above do
               not apply if the information required to be included in a
               post-effective amendment by those paragraphs is contained in
               periodic reports filed with or furnished to the Securities and
               Exchange Commission by the Company pursuant to Section 13 or
               Section 15(d) of the Exchange Act that are incorporated by
               reference in the Registration Statement.

                                      -5-

<PAGE>

        (2)    That, for the purpose of determining any liability under the
               Securities Act, each such post-effective amendment shall be
               deemed to be a new registration statement relating to the
               securities offered therein, and the offering of such securities
               at that time shall be deemed to be the initial bona fide offering
               thereof.

        (3)    To remove from registration by means of a post-effective
               amendment any of the securities being registered which remain
               unsold at the termination of the offering.

        (4)    That, for purposes of determining any liability under the
               Securities Act, each filing of the Company's annual report
               pursuant to Section 13(a) or Section 15(d) of the Exchange Act
               that is incorporated by reference in the Registration Statement
               shall be deemed to be a new registration statement relating to
               the securities offered therein, and the offering of such
               securities at that time shall be deemed to be the initial bona
               fide offering thereof.

        (5)    Insofar as indemnification for liabilities arising under the
               Securities Act may be permitted to directors, officers and
               controlling persons of the Company pursuant to the foregoing
               provisions, or otherwise, the Company has been advised that in
               the opinion of the Securities and Exchange Commission such
               indemnification is against public policy as expressed in the
               Securities Act and is, therefore, unenforceable. In the event
               that a claim for indemnification against such liabilities (other
               than the payment by the Company of expenses incurred or paid by a
               director, officer or controlling person of the Company in the
               successful defense of any action, suit or proceeding) is asserted
               by such director, officer or controlling person in connection
               with the securities being registered, the Company will, unless in
               the opinion of its counsel the matter has been settled by
               controlling precedent, submit to a court of appropriate
               jurisdiction the question whether such indemnification by it is
               against public policy as expressed in the Securities Act and will
               be governed by the final adjudication of such issue.

                                      -6-

<PAGE>

                                   SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, as amended,
the Company certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Denton, State of Texas on January 22, 1999.

                                    INTERNATIONAL ISOTOPES INC.

                                    By: /s/ Ira Lon Morgan
                                        -------------------------------------
                                        Ira Lon Morgan, Ph.D.
                                        Chairman of the Board of Directors


                                    By: /s/ Carl W. Seidel
                                        -------------------------------------
                                        Carl W. Seidel
                                        President, Chief Executive Officer
                                        and Director

                                      -7-

<PAGE>

                                POWER OF ATTORNEY

        KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below hereby constitutes and appoints Ira Lon Morgan, Ph.D. and Carl W. Seidel,
each of them or an one of them, as his or her true and lawful attorneys-in-fact
and agents with full power of substitution and resubstitution, for him or her
and in his or her name, place and stead, in any and all capacities, to sign any
and all amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and all other
documents in connection therewith, with the Securities and Exchange Commission
and any state or other securities authority, granting unto said
attorneys-in-fact and agents and each of them or any of them, full power and
authority to do and perform each and every act in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or his or her or their
substitute or substitutes may lawfully do or cause to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>

        Signature                           Title                              Date
        ---------                           -----                              ----
<S>                           <C>                                         <C>
/s/ Ira Lon Morgan            Chairman of the Board of Directors          January 22, 1999
- ---------------------------   and Treasurer
    Ira Lon Morgan, Ph.D.


/s/ Carl W. Seidel            President, Chief Executive Officer          January 22, 1999
- ---------------------------   and Director (Principal Executive Officer)
    Carl W. Seidel              


/s/ Tommy L. Thompson         Executive Vice President, Chief Operating   January 22, 1999
- ---------------------------   Officer and Director
    Tommy L. Thompson           


/s/ Joan H. Gillett           Chief Financial Officer (Principal          January 22, 1999
- ---------------------------   Financial and Principal Accounting
    Joan H. Gillett           Officer)


/s/ Virgil L. Simmons         Senior Vice President of International      January 22,1999
- ---------------------------   Marketing and Director
    Virgil L. Simmons           


/s/ John M. McCormack         Director                                    January 22, 1999
- ---------------------------
    John M. McCormack

                                      -8-

<PAGE>


/s/ William W. Nicholson      Director                                    January 22, 1999
- ---------------------------
    William W. Nicholson


/s/ Charles LeMaistre         Director                                    January 22, 1999
- ---------------------------
    Charles LeMaistre, M.D.


/s/ Robert J. Gary            Director                                    January 22, 1999
- ---------------------------
    Robert J. Gary


- ----------------------------  Director                                    January ___, 1999
    Frederick J. Bonte, M.D.

</TABLE>

                                      -9-

<PAGE>


                     INDEX TO EXHIBITS


                                                   Sequentially
Exhibit                                              Numbered
 Number                    Exhibit                     Page
- -------                    -------
  4.1           Specimen Stock Certificate
                of the Company (incorporated
                by reference to the
                corresponding Exhibit Number
                in the Company's Registration   
                Statement on Form SB-2 (Registration 
                No. 333-26269) filed with the
                Securities and Exchange
                Commission on May 1, 1997).

  4.2           Articles of Incorporation of
                the Company (incorporated by
                reference to Exhibit Number
                3.1 to the Company's Registration   
                Statement on Form SB-2 (Registration 
                No. 333-26269) filed with the
                Securities and Exchange
                Commission on May 1, 1997).

  4.3           Bylaws of the Company (incorporated
                by reference to Exhibit Number 3.2
                in the Company's Registration
                Statement on Form SB-2 (Registration
                No. 333-26269) filed with the 
                Securities and Exchange commission on
                May 1, 1997).

  5.1           Opinion of Locke Liddell & Sapp LLP.

  23.1          Consent of KPMG LLP, Independent Accountants.


<PAGE>


  23.2          Consent of Locke Liddell &
                Sapp LLP (included in  its
                opinion filed as Exhibit
                5.1).

  24.1          Power of Attorney (included
                on the signature page of
                this Registration Statement).

  99.1          International Isotopes Inc.
                1997 Long Term Incentive
                Plan (incorporated by
                reference to Exhibit 10.1 to
                Amendment No. 1 to the
                Company's Registration
                Statement on Form SB-2
                (Registration  No. 333-26269)
                previously filed with the
                Securities and Exchange
                Commission).




                                   EXHIBIT 5.1

                                  Legal Opinion


<PAGE>


                                                        (512) 305-4716


                                                        January 22, 1999

International Isotopes Inc.
3100 Jim Christal Road
Denton, TX 76207

         Re:      Registration of 600,000 shares of Common Stock pursuant to a
                  Registration Statement on Form S-8

Gentlemen:

        We have acted as counsel for International Isotopes Inc., a Texas
corporation (the "Company"), in connection with the registration under the
Securities Act of 1933, as amended (the "Securities Act"), pursuant to a
Registration Statement on Form S-8 (the "Registration Statement") of 600,000
shares of Common Stock, $.01 par value, of the Company ("Common Stock") to be
issued pursuant to the exercise of options (the "Options") granted or to be
granted by the Company to certain key employees, directors and consultants
pursuant to the Company's 1997 Long Term Incentive Plan (the "Plan").

        We have made such inquires and examined such documents as we have
considered necessary or appropriate for the purpose of giving the opinions
hereinafter set forth. We have assumed the genuineness and authenticity of all
signatures on all original documents, the authenticity of all documents
submitted to us as originals, the conformity to originals of all documents
submitted to us as copies and the due authorization, execution, delivery or
recordation of all documents where due authorization, execution or recordation
are prerequisites to the effectiveness thereof.

        Based upon the foregoing, having regard for such legal considerations as
we deem relevant, and assuming, with respect to the shares of Common Stock
issued under the Options (i) the receipt of proper consideration for the
issuance thereof in excess of the par value thereof, (ii) the availability of a
sufficient number of shares of Common Stock authorized by the Company's Articles
of Incorporation then in effect, (iii) compliance with the terms of the Plan,
and (iv) no change occurs in applicable law or the pertinent facts, we are of
the opinion that the 600,000 shares of Common Stock that may be issued and sold
by the Company from time to time upon exercise of the Options, as described in
the Registration Statement, will, upon issuance and delivery against payment
therefor, be duly authorized and legally issued, fully paid and nonassessable.


<PAGE>


International Isotopes Inc.
January 22, 1999
Page 2

        We hereby consent to the filing of this opinion with the Securities and
Exchange Commission as an exhibit to the Registration Statement. By so
consenting, we do not thereby admit that our firm's consent is required by
Section 7 of the Securities Act.

                                            Very truly yours,

                                            LOCKE LIDDELL & SAPP LLP


                                            /s/ Locke Liddell & Sapp LLP

CRA/bsa




                                                                    EXHIBIT 23.1


                       CONSENT OF INDEPENDENT ACCOUNTANTS

Board of Directors
International Isotopes Inc.

We consent to the use of our report incorporated herein by reference.


/s/ KPMG LLP
KPMG LLP
Dallas, Texas
January 28, 1999



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