KENDLE INTERNATIONAL INC
S-8, 1997-08-22
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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    As filed with the Securities and Exchange Commission on August 22, 1997.
                                                  Registration No. 333-
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933


   Incorporated             KENDLE INTERNATIONAL INC.          I.R.S. Employer
  Under the Laws           441 VINE STREET, SUITE 700         Identification No.
   of Ohio                  CINCINNATI, OHIO  45202              31-1274091
                               (513) 771-8221


              1995 AND 1997 STOCK OPTION AND STOCK INCENTIVE PLANS


                              Gary P. Kreider, Esq.
                           Keating, Muething & Klekamp
                             One East Fourth Street
                             Cincinnati, Ohio 45202
                                 (513) 579-6411
- --------------------------------------------------------------------------------
                         (Agent for Service of Process)



                         CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------
                                         Proposed     Proposed
                                         Maximum      Maximum
     Title of             Amount         Offering     Aggregate      Amount of
    Securities             To Be           Price      Offering     Registration
 To Be Registered       Registered     Per Share(1)   Price(1)        Fee(2)
- -------------------  ----------------  ------------   ---------    -------------
   Common Stock,
   No par value      1,743,907 Shares     $14.00     $24,414,698      $7,399
- --------------------------------------------------------------------------------

(1)  Estimated to calculate  registration  fee. 
(2)  Calculated pursuant to Rule 457(h) based on the average of the high and low
     prices of the Common Stock on the Nasdaq National Market on August 21, 1997
     of $14 per share.



<PAGE>
                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference

        The  following  documents  filed  by  Kendle   International  Inc.  (the
"Company"),  with the Securities and Exchange Commission are incorporated herein
by reference and made a part hereof:

     1.   Prospectus  dated August 22, 1997 filed  pursuant to Rule 424(b) under
          the Securities Act of 1933.

        All  reports  and  other  documents  subsequently  filed by the  Company
pursuant to Sections 13(a),  13(c), 14 and 15(d) of the Securities  Exchange Act
of 1934, prior to the filing of a post-effective  amendment which indicates that
all Common  Stock  offered has been sold or which  deregisters  all Common Stock
then remaining  unsold,  shall be deemed to be incorporated by reference in this
Registration  Statement  and to be a part  hereof  from the date of filing  such
documents.


Item 4. Description of Securities

        Not Applicable.


Item 5. Interests of Named Experts and Counsel

        The legality of the Common Stock offered  hereby will be passed upon for
the Company by Keating,  Muething & Klekamp,  P.L.L.,  1800 Provident Tower, One
East Fourth Street,  Cincinnati,  Ohio 45202.  Attorneys of Keating,  Muething &
Klekamp own 6,000 shares of the Company's Common Stock.


Item 6. Indemnification of Directors and Officers

        Ohio Revised Code,  Section  1701.13(E),  allows  indemnification by the
registrant  to  any  person  made  or  threatened  to be  made  a  party  to any
proceedings,  other than a proceeding by or in the right of the  registrant,  by
reason of the fact that he is or was a director,  officer,  employee or agent of
the registrant,  against expenses,  including judgment and fines, if he acted in
good faith and in a manner  reasonably  believed  to be in or not opposed to the
best interests of the registrant and, with respect to criminal actions, in which
he had no  reasonable  cause to believe that his conduct was  unlawful.  Similar
provisions apply to actions brought by or in the right of the registrant, except
that


<PAGE>

no  indemnification  shall be made in such cases when the person shall have been
adjudged to be liable for  negligence  or misconduct  to the  registrant  unless
deemed otherwise by the court.  Indemnification is to be made by a majority vote
of a quorum of  disinterested  directors or the written  opinion of  independent
counsel  or by the  shareholders  or by the  court.  The  registrant's  Code  of
Regulations extends such indemnification.


Item 7. Exemption from Registration Claimed

        Not Applicable.


Item 8. Exhibits*


  Exhibit 4.1            1995 Stock Option and Stock Incentive Plan
  Exhibit 4.2            1997 Stock Option and Stock Incentive Plan
  Exhibit 5              Opinion of Keating, Muething & Klekamp, P.L.L.
  Exhibit 23.1           Consent of Coopers & Lybrand L.L.P.
  Exhibit 23.2           Consent of Keating, Muething & Klekamp, P.L.L.
                          (included in Exhibit 5)
  Exhibit 24             Power of Attorney (contained on the signature page)
- --------------
  *All Exhibits filed herewith.


Item 9. Undertakings

     9.1 The undersigned  registrant  hereby  undertakes to include any material
information with respect to the plan of distribution not previously disclosed in
the  Registration  Statement or any material  change to such  information in the
Registration Statement.

     9.2 The undersigned  registrant  hereby undertakes that, for the purpose of
determining   any  liability  under  the  Securities  Act  of  1933,  each  such
post-effective  amendment  shall be  deemed to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     9.3  The   undersigned   registrant   hereby   undertakes  to  remove  from
registration by means of a post-effective  amendment any of the securities being
registered which remain unsold at the termination of the offering.


<PAGE>

     9.4 The  undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     9.5 Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers and controlling  persons of
the  registrant  pursuant  to  the  foregoing  provisions,   or  otherwise,  the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

<PAGE>

                                   SIGNATURES

        Pursuant  to  the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in Cincinnati, Ohio, on August 22, 1997.

                                                   KENDLE INTERNATIONAL INC.


                                                   By:/S/ Candace Kendle Bryan
                                                      --------------------------
                                                      Candace Kendle Bryan
                                                      Chairman of the Board and
                                                      Chief Executive Officer

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities  and on the dates  indicated.  Persons whose names are marked with an
asterisk (*) below hereby designate Candace Kendle Bryan or Timothy M. Mooney as
their  attorney-in-fact  to sign all  amendments,  including any  post-effective
amend ments, to this Registration Statement.


           Signature                       Capacity                 Date
           ---------                       --------                 ----


*/S/ Candace Kendle Bryan       Chairman of the Board and       August 22,1997
- ---------------------------     Chief Executive Officer 
Candace Kendle Bryan            Principal Executive Officer)
                            

*/S/ Christopher C. Bergen      President, Chief Operating      August 22,1997
- ---------------------------     Officer, Secretary  
Christopher C. Bergen           and Director

*/S/ Timothy M. Mooney          Vice President- Finance,        August 22,1997
- ---------------------------     Chief Financial Officer, 
Timothy M. Mooney               Treasurer, Assistant 
                                Secretary (principal
                                financial officer and 
                                principal accounting 
                                officer) and Director

*                           
- ---------------------------     Director                        August 22,1997
Philip E. Beekman

*                           
- ---------------------------     Director                        August 22,1997
Charles A. Sanders




                                                                     EXHIBIT 4.1

                               KENDLE RESEARCH ASSOCIATES, INC.

                                       1995 STOCK OPTION
                                   AND STOCK INCENTIVE PLAN

(1)  ESTABLISHMENT OF THE PLAN

        Kendle  Research  Associates,  Inc.,  an Ohio  corporation  (hereinafter
referred  to as the  "Company"),  herein  sets forth the terms of its 1995 Stock
Option and Stock  Incentive Plan  (hereinafter  referred to as the "Plan").  

(2)  DEFINITIONS

     For  purposes of the Plan,  the  following  terms shall have the  following
meanings:

     (a)  "BOARD" means the Board of Directors of the Company.

     (b)  "CODE"  means  the  U.S.   Internal  Revenue  Code  of  1986  and  the
          Regulations thereunder, as now or hereafter amended.

     (c)  "COMMON  STOCK" or "SHARES"  means  shares of the no par value  common
          stock of the Company.

     (d)  "COMPANY" means Kendle Research Associates, Inc., an Ohio corporation,
          and any of its parent  corporations or wholly-owned or  majority-owned
          subsidiary corporations.

     (e)  "FAIR MARKET  VALUE," when used in reference to Shares of Common Stock
          shall  mean:  (i)  the  value  determined  by the  application  of the
          following formula (the "Fair Market Value Formula"):

<PAGE>

          A.   First,  the Company's  "Debt-Free  Cash Flow" for the fiscal year
               ending  immediately  prior to the date of the  event in  question
               (i.e., a grant or award under the Plan, the Company's exercise of
               a purchase  option,  or any other event requiring a determination
               of the Shares'  Fair Market  Value)  shall be  determined  by the
               Board.  For purposes of this Plan, the Company's "Debt- Free Cash
               Flow" shall mean the  Company's  net income after  income  taxes,
               plus  depreciation,  amortization,  interest  income and interest
               expense, as adjusted for any extraordinary gains, losses or other
               items,  discontinued  operations,  and  non-operating  income  or
               losses.

          B.   Second,  the  Company's  Fair Market Value shall be determined by
               multiplying  the  Company's  "Debt-Free  Cash Flow" as determined
               above by a  valuation  multiple  determined  by the Board in good
               faith on an annual  basis and based on  reasonable  business  and
               economic factors. 

          C.   Third,  the Fair Market  Value per Share shall be  determined  by
               dividing the Corporation's  Fair Market Value as determined above
               by the number of shares which are issued and  outstanding  on the
               date  of  the  event  in  question.  

          or (ii) such value as is  determined  by the Board in good faith using
          any reasonable  valuation method.

     (f)  "PARTICIPANT"  means an officer,  employee,  director,  consultant  or
          advisor of the Company  who has been  granted an option or award under
          the Plan.

     (g)  "PLAN SHARES" means any Shares of Common Stock issued to a Participant
          in connection with an option, grant or award under the Plan.


<PAGE>


(3)     PURPOSES OF THE PLAN
        The purposes of the Plan are to provide the Participants with additional
incentive  and  motivation  to  contribute  to the  Company's  future growth and
continued  success,  by providing  them with the  opportunity  to obtain a stock
ownership  interest  in the  Company,  and to enable the  Company to attract and
retain the services of qualified officers, employees, directors, consultants and
advisors.  The Plan is also  intended to reinforce the  commonality  of interest
between  the  Company's  shareholders  and  the  Participants  in the  Plan  

(4)     ADMINISTRATION

     (a)  The Plan  shall be  administered  by the  Board  of  Directors  of the
          Company.

     (b)  Subject to any specific  limitations  contained in the Plan, the Board
          shall  have  the  sole  and  complete  authority:  (i) to  select  the
          officers,  employees,  directors,  consultants  and advisors who shall
          participate in the Plan; (ii) to make awards in such forms and amounts
          as it shall determine; (iii) to impose such limitations,  restrictions
          or  conditions  upon  awards  as it shall  deem  appropriate;  (iv) to
          modify,  amend,  cancel or  suspend  awards,  with the  consent of any
          Participant  affected thereby; (v) to interpret the Plan and to adopt,
          amend  and  rescind  administrative  guidelines  and  other  rules and
          regulations  relating  to  the  Plan;  and  (vi)  to  make  all  other
          determinations  and to take all other  actions  necessary or advisable
          for the proper administration of the Plan. The Board's  interpretation
          and construction of any provision of the Plan, or of any award granted
          under it, and any actions taken by the Board under the Plan,  shall be
          final and conclusive upon the Company,  the Participants and all other
          parties.

<PAGE>


     (c)  With respect to actions  taken  affecting  the Plan, a majority of the
          Board  shall  constitute  a quorum,  and the acts of a majority of the
          members  present  at any  meeting  of the  Board at which a quorum  is
          present, or acts approved in writing by a majority of the Board, shall
          be considered  as valid actions by the Board.  The Board may designate
          one or more officers or employees of the Company to execute  documents
          on its behalf or to perform such other non- discretionary, ministerial
          duties as the Board may determine,

 (5) TYPES OF AWARDS

     The following  kinds or types of awards may be granted under the Plan:  (a)
Incentive Stock Options;  (b) Non-Qualified Stock Options; (c) Restricted Stock;
(d) Performance  Units; and (e) other stock awards or bonuses valued in whole or
in pan by reference to or which relay be payable in Shares.  In connection  with
any award or any deferred  award  granted  under the Plan,  payments may also be
made representing dividends,  interest, or their equivalent.  

(6) ELIGIBILITY TO PARTICIPATE 

     Only  persons  who  are  officers,  employees,  directors,  consultants  or
advisors of the  Company  shall be  eligible  to  participate  in and to receive
awards  under the Plan.  For  purposes of this Plan,  the term  "consultant"  or
"advisor"  shall mean a  consultant  or advisor who has or will render bona fide
services  to the  Company  other  than in  connection  with the offer or sale of
securities in a capital raising transaction.  An individual Participant may hold
more than one award  under the Plan or under any  similar  plans  adopted by the
Company.  

(7)  SHARES  SUBJECT  TO THE  PLAN 

     (a) The Shares to be issued and  delivered by the Company upon the exercise
of options or the payment of other awards granted under the Plan shall be Shares
of the no par value Common Stock,  which may be either  authorized  but unissued
shares or treasury shares as determined by the Board.


<PAGE>


     (b) The maximum  number of Shares of Common Stock which may be issued under
the Plan  shall be One  Hundred  Thousand  (100,000)  Shares.  In the event of a
change in the  number or nature of the  Shares of  outstanding  Common  Stock by
reason of a stock dividend, stock split, reverse stock split,  recapitalization,
reorganization,   merger,   exchange  of  shares,   or  other  similar   capital
adjustments: (i) equitable proportionate adjustments may be made by the Board in
the number or kind of reserved for issuance pursuant to awards granted under the
Plan; and (ii) with to any outstanding options or other awards granted under the
Plan,  equitable  proportionate  adjustments  shall be made by the  Board to the
number,  class,  exercise  price,  or other  price  of  Shares  subject  to such
outstanding options or awards as the Board shall deem to be appropriate in order
to maintain the purpose of the original grant. The determination of the Board as
to any such adjustment shall be final,  binding and conclusive 

     (c) If any option  granted under the Plan shall expire or terminate for any
reason  without having been exercised in full, the Shares subject to such option
shall again be available for issuance in  connection  with the grant of any type
of award  under the Plan.  If any Shares  subject to any other type of award are
forfeited,  or the award is terminated  without  issuance of the Shares or other
consideration,  the Shares  subject to such award shall again be  available  for
issuance in connection  with the grant of any type of award under the Plan.  

(8)  STOCK OPTIONS 

     All Stock Options  granted under the Plan shall be subject to the following
terms and  conditions:  

     (a) The Board  may,  from time to time in its  discretion,  subject  to the
provisions of the Plan,  grant to any eligible  Participant  options to purchase
Shares of Common Stock in such amounts as it shall determine,  which options may
be "Incentive  Stock Options" (as defined in ss.422 of the Code and  hereinafter
referred  to as "ISOs") or  "Non-Qualified  Stock  Options"  (all other  options
granted hereunder); provided, that ISOs may only be granted to a person who is a
bona fide  "employee"  of the Company at the time of the grant,  as that term is
defined in the Code. All options granted pursuant to the Plan shall be evidenced
by a written Stock Option Agreement between the Company and the Participant. The
Stock Option  Agreement  shall be in such form and shall  contain such terms and
conditions  as the Board  shall  determine.  The Stock  Option  Agreement  shall
indicate whether the option is an ISO or a Non-Qualified  Stock Option.  

     (b) The purchase price per share payable by a Participant upon the exercise
of each option  granted  under the Plan shall be  determined by the Board at the
time of the grant of the option;  provided,  that:  (i) the exercise or purchase
price per share of each Non-Qualified Stock Option shall not be less than ninety
percent  (90%) of the Fair Market  Value of the Shares on the date of the grant,
and (ii) the exercise or purchase  price per share of each ISO shall not be less
than One Hundred  (100%)  percent of the Fair Market  Value of the Shares on the
date of the grant,  except as  hereinafter  provided.  The  exercise or purchase
price per share of each ISO  granted to a  Participant  who,  at the time of the
grant,  owns more than Ten (10%) percent of the total  combined  voting power of
all  classes of stock of the  Company,  shall not be less than One  Hundred  Ten
(110%)  percent of the Fair Market Value of the Shares on the date of the grant.
An option shall be considered  granted on the effective date of the Stock Option
Agreement,  or on such later date as the Board shall specify in the Stock Option
Agreement.  

<PAGE>


     (c) The  term  during  which  each  option  granted  under  the Plan may be
exercised  shall be  determined  by the  Board  at the time of the  grant of the
option;  provided,  that in no event  shall  an ISO  granted  under  the Plan be
exercisable  in whole or in part  more than ten (10)  years  from the date it is
granted.  In addition,  in the case of the grant of an ISO to a Participant who,
at the time of the grant, owns more than Ten (10%) percent of the total combined
voting power of all classes of stock of the Company,  in no event shall such ISO
be  exercisable in whole or in part more than five (5) years from the date it is
granted. Each Stock Option Agreement shall set forth a termination date on which
the option shall expire in all events.

     The  date(s)  on which each  option  granted  under the Plan  shall  become
exercisable  shall be  determined  by the  Board at the time of the grant of the
option. Options granted under the Plan may be exercisable immediately,  or after
some  specified  period of time,  or  according  to some  specified  schedule of
exercise,  as  determined by the Board.  The Board may, in its sole  discretion,
accelerate  the date(s) on which an option may be  exercised.  

     (d) More than one (1) option may be granted to any  individual  Participant
under the Plan,  and the terms and  conditions  of  options  granted to the same
Participant or to other Participants may differ. Other than the overall limit on
the number of Shares reserved for issuance under the Plan,  there is no specific
limitation  on the  number of Shares  for which  options  may be  granted to any
individual  Participant,  except as  hereinafter  provided.  No option  which is
intended to be an ISO shall be granted to a Participant during any calendar year
if the  aggregate  fair  market  value  (determined  at the time the  option  is
granted) of Shares with respect to which ISOs are exercisable for the first time
by such  Participant  during  that  calendar  year under this or any other stock
option plan of the Company exceeds One Hundred Thousand  ($100,000.00)  Dollars.


<PAGE>

     (e) An option granted under the Plan shall be exercised by the  Participant
or by such other person as may be entitled to exercise the option, by sending or
delivering a written notice to the Board,  or to such officer or other person as
the Board shall  designate.  The written notice shall state the number of Shares
with respect to which the option is being exercised, and shall be accompanied by
the payment of the full exercise or purchase price for such Shares. The exercise
or purchase  price for the Shares may be paid in cash,  or in the  discretion of
the  Board  with  shares  of  Common  Stock  or any  other  property,  or in any
combination  thereof. In addition,  the Board, in its discretion,  may allow for
the cashless exercise or conversion of an option, in which the Participant sells
or the Company  retains option shares equal in Fair Market Value to the exercise
price. Any Shares of Common Stock that are delivered in total or partial payment
of the  exercise  or purchase  price shall be valued at the Shares'  Fair Market
Value on the date of the  exercise of the  option,  or on such other date as the
Board may  determine.  A stock  certificate(s)  for the Shares  purchased by the
exercise  of an option  shall be issued in the regular  course of the  Company's
business,  subsequent  to the  exercise  of the  option  and the  payment of the
purchase price. No Participant  entitled to exercise an option granted under the
Plan shall have any of the rights or privileges of a shareholder  of the Company
with  respect  to any  Shares  issuable  upon  exercise  of such  option,  until
certificates  representing  such Shares shall have been issued and delivered and
the  Participant's  name entered as a shareholder  of record on the books of the
Company. 


<PAGE>

     (f)  Options  granted  under the Plan shall not be  assigned,  transferred,
pledged or otherwise  encumbered in any way, except in the event of the death of
a Participant,  by the  Participant's  Will or by the applicable laws of descent
and distribution, or except pursuant to a qualified domestic relations order. In
the event of the death of a  Participant,  the  Participant's  estate,  personal
representative, or the person or persons who acquire (by bequest or inheritance)
the rights to exercise  any options  granted  under the Plan,  may  exercise any
available  options or parts  thereof,  prior to the  expiration  of the exercise
period  described in Paragraph (8)(g) of the Plan. Each option granted under the
Plan  shall  be  exercisable  during  the  Participants  lifetime  only  by  the
Participant  or, if  permissible  under  applicable  law,  by the  Participant's
guardian or legal representative.

        (g) (i) events upon the date  determined by the Board at the time of the
grant of the option and specified in the Stock Option Agreement, which date with
respect to ISOs shall not exceed the periods  described in  Paragraph  (8)(c) of
the Plan.

        (ii) Unless otherwise  specified in the Stock Option  Agreement  between
the Company and the Participant, if a Participant's employment, directorship, or
consulting  relationship  with  the  Company  (hereinafter  referred  to as  the
"Company Relationship") is terminated for any reason, other than "for cause," as
hereinafter  defined,  or other  than  because  of the  Participant's  permanent
disability or death,  any  outstanding  vested options may be exercised,  to the
extent such options were vested and  exercisable  on the date the  Participant's
Company Relationship was terminated,  for a period of 90 days following the date
of such  termination.  If not exercised within such 90 day period,  such options
shall  terminate.  Any options which were not vested or  exercisable on the date
the   Participant's   Company   Relationship   was  terminated  shall  terminate
immediately on that date. The Board may, in its sole  discretion,  grant options
under the Plan which survive,  either in whole or in part, the  termination of a
Participants  Company  Relationship for a period shorter or longer than 90 days,
upon such terms and  conditions  as the Board may  determine.  In addition,  the
Board  may,  in its  sole  discretion,  at the  time  of  the  termination  of a
Participants Company Relationship, extend the exercise period of any option that
would otherwise have terminated.  In no event, however, shall any option granted
under the Plan survive beyond the date described in Paragraph (8)(g)(i) above.


<PAGE>



     (iii) All options granted to a Participant  under the Plan,  whether or not
vested or exercisable, shall terminate immediately on the date the Participant's
Company  Relationship  is terminated  "for cause' as  hereinafter  defined.  For
purposes  of the Plan,  a  Participant's  Company  Relationship  shall be deemed
terminated "for cause" if terminated because of: (i) the Participant's  material
breach  of an  employment  agreement,  consulting  agreement,  agreement  not to
compete, confidentiality agreement or other agreement with the Company, (ii) the
Participants theft of Company property,  (iii) the Participant's conviction of a
felony or of a misdemeanor which materially impairs the Participant's ability to
perform his duties with the Company,  (iv) the willful and continued  failure by
the  Participant  to  substantially  perform his duties with the Company,  (v) a
material  misrepresentation  in or omission from a Participant's job application
or job interview, (vi) unlawful possession or use of drugs, or (vii) willful and
continued  conduct  by the  Participant  which is  demonstrably  and  materially
injurious  to the  Company,  monetarily  or  otherwise.  

     (iv) Unless otherwise  specified in the Stock Option Agreement  between the
Company  and  the  Participant,  if  a  Participant's  Company  Relationship  is
terminated by reason of the  Participant's  permanent  disability or death,  any
outstanding  vested  options may be  exercised,  to the extent such options were
vested and exercisable on the date of the Participant's  permanent disability or
death, for a period of 12 months  following the date of permanent  disability or
death.  If not  exercised  within  such 12  month  period,  such  options  shall
terminate.  Any options which were not vested or  exercisable on the date of the
Participant's death or permanent disability shall terminate  immediately on that
date. The Board may, in its sole discretion,  grant options under the Plan which
survive,  either in whole or in part,  the  permanent  disability  or death of a
Participant  for a period of up to 36 months,  upon such terms and conditions as
the Board may determine.  In no event,  however,  shall any option granted under
the Plan survive beyond the date described in Paragraph (8)(g)(i) above.

<PAGE>



(9)     RESTRICTED STOCK

     All awards of Restricted  Stock made under the Plan shall be subject to the
following terms and conditions:

     (a) The Board  may,  from time to time in its  discretion,  subject  to the
provisions of the Plan,  award Shares of Restricted  Stock to any Participant in
such  amounts as it shall  determine.  The Company  shall issue and deliver to a
Participant  to whom an award of Restricted  Stock has been made,  the number of
Shares  specified by the Board.  A  Participant  to whom an award of  Restricted
Stock has been made shall not be required to provide and  consideration  for the
Shares,  other than the  rendering  of  services  or the  payment of any minimum
amount  required by applicable law,  unless  otherwise  determined by the Board.
Each award of  Restricted  Stock made  under the Plan  shall be  evidenced  by a
written Restricted Stock Agreement between the Company and the Participant.  The
Restricted  Stock  Agreement  shall be in such form and shall contain such terms
and  conditions  as the  Board  shall  determine  More  than  one (1)  award  of
Restricted Stock may be granted to an individual Participant under the Plan, and
the  terms  and  conditions  of  Restricted  Stock  Awards  granted  to the same
Participant  or to other  Participants  may  differ.  

     (b) Except as hereinafter  provided,  Shares of Restricted Stock may not be
sold,  assigned,  transferred,  pledged or otherwise encumbered by a Participant
during the "Restricted  Period." The Restricted Period is the period of time, if
any, determined by the Board in its discretion, during which the Participant may
not sell, assign, transfer,  pledge, or otherwise encumber the Shares and during
which the Shares are subject to  forfeiture  back to the Company.  The Board may



<PAGE>



impost such additional  limitations on the ownership of Restricted  Stock during
the Restricted Period as it may determine.  The Restricted Period shall commence
upon the date of the award of the Restricted  Stock to the Participant and shall
terminate  on the  date(s)  determined  by the  Board  in  its  discretion.  The
termination  date(s) of the Restricted  Period may be a single date on which all
of the Shares  subject to the award are  released  from the  transfer  and other
restrictions  or may be several  dates on which a specified  percentage  of such
Shares are released from such restrictions.  Except as hereinafter provided, the
Board  may,  in its  sole  discretion,  accelerate  the  date(s)  on  which  the
Restricted  Period will terminate.  Except for the  restrictions on transfer and
unless  otherwise  determined by the Board,  any  Participant who owns Shares of
Restricted  Stock shall have all of the rights of a shareholder  with respect to
such  Shares,  Including  but not limited to, the right to vote and the right to
receive dividends.

     (c) Each  stock  certificate  issued by the  Company  evidencing  Shares of
Restricted  Stock  awarded under the Plan shall be registered in the name of the
Participant  and shall bear the  following or a similar  legend:  "The shares of
stock  represented by this  Certificate  are subject to the terms and conditions
(including  forfeiture)  contained in the Kendle Research Associates,  Inc. 1995
Stock  Option  and  Stock  Incentive  Plan  and  may  not  be  sold,   assigned,
transferred,  pledged or otherwise encumbered in any manner until _____________,
_______.

     (d) If a  Participant's  Company  Relationship  is  terminated  during  the
Restricted  Period for any reason,  all of the Shares of Restricted  Stock which
are not then vested  shall be  forfeited  back to the  Company,  subject to such
exceptions,  if  any,  as  are  authorized  by the  Board  with  respect  to the
termination of a Participant's  Company  Relationship due to normal  retirement,
permanent disability,  death, change of control, or other special circumstances.
Awards  of  Restricted  Stock  made  under  the  Plan  shall  not  be  assigned,


<PAGE>



transferred,  pledged or otherwise encumbered in any way. except in the event of
the death of a Participant,  by the Participants  Will or by the applicable laws
of  descent  and  distribution,  or  except  pursuant  to a  qualified  domestic
relations order.

     (e) Upon the lapse of the Restricted Period, the Shares of Restricted Stock
shall no longer be subject to the  restrictions  described in this Paragraph (9)
and the Company shall issue new stock  certificates for the Shares registered in
the name of the  Participant  without the legend  described in Paragraph  (9)(c)
hereof.

     (f) Any Shares of the Company's  Common Stock issued to a Participant  with
respect to  Restricted  Stock as a result of a stock  split,  stock  dividend or
similar  transaction  shall be restricted to the same extent as such  Restricted
Stock, unless otherwise determined by the Board.

     (g) All other terms and conditions of an award of Restricted Stock shall be
determined by the Board.

(10)    PERFORMANCE UNIT AWARDS

        All awards of Performance  Units made under the Plan shall be subject to
the following terms and conditions:

     (a) The Board  may,  from time to time in its  discretion,  subject  to the
provisions  of the Plan,  award  Performance  Units to any  Participant  in such
amounts as it shall  determine.  Each Performance Unit shall represent the right
of a Participant  to receive an amount equal to a Payment  Value,  which Payment
Value shall be determined  by the Board and shall be based upon the  performance
of the Participant, the Company, or a division of the Company over a Performance
Period. A Participant to whom an award of Performance  Units has been made shall
not be required to provide any  consideration  for a Performance Unit other than


<PAGE>


the  rendering  of services or the  payment of any  minimum  amount  required by
applicable law, unless otherwise  determined by the Board. Each Performance Unit
awarded  under  the Plan  shall  be  evidenced  by a  written  Performance  Unit
Agreement  between  the  Company  and  the  Participant.  The  Performance  Unit
Agreement  shall be in such form and shall contain such terms and  conditions as
the Board shall determine.

     (b) The Performance Period for each Performance Unit awarded under the Plan
shall be of such duration as the Board shall establish at the time of the award.
The performance  criteria for each Performance Unit awarded under the Plan shall
be  determined  by the Board.  More than one award of  Performance  Units may be
granted  to any  individual  Participant  under  the  Plan,  and the  terms  and
condition  of  Performance  Units  granted to the same  Participant  or to other
Participants,  such as the  Performance  Periods and performance  criteria,  may
differ. If during a Performance Period there should occur, in the opinion of the
Board,  significant  changes  in  economic  conditions  or in the  nature of the
operations  of the Company which the Board did not foresee in  establishing  the
performance  criteria for such Performance Period, and which in the Board's sole
judgment,   have,  or  are  expected  to  have,  a  substantial  effect  on  the
Participant's  or the Company's  ability to meet the performance  criteria,  the
Board may revise the performance  criteria  formerly  determined by it in such a
manner as the Board, in its sole judgment, may deem appropriate

     (c) An award of Performance  Units to a Participant shall terminate for all
purposes if the  Participant  does not remain,  during the  Performance  Period,
continuously  in the  employ or other  service of the  Company,  subject to such
exceptions,  if  any,  as are  authorized  by the  Board,  with  respect  to the
termination of a Participants  Company  Relationship  due to normal  retirement,
permanent disability,  death or other special  circumstances.  Performance Units
awarded under the Plan shall not be assigned, transferred,  pledged or otherwise
encumbered in any way, except in the event of the death of a Participant, by the
Participant's  Will or by the applicable  laws of descent and  distribution,  or
except pursuant to a qualified domestic relations order.

<PAGE>


     (d) The Payment Value of a Performance  Unit shall be paid to a Participant
in cash,  in Shares of Common Stock,  or in a combination  of cash and Shares as
determined  by  the  Board  in its  sole  discretion.  The  Payment  Value  of a
Performance  Unit shall be paid to the  Participant  on such date  following the
conclusion of the Performance Period as the Board shall designate at the time of
the award.

     (e) All other terms and conditions of an award of  Performance  Units shall
be determined by the Board.

(11)    OTHER STOCK UNIT AWARDS

     (a) The Board  may,  from time to time in its  discretion,  subject  to the
provisions of the Plan, grant to any Participant, either alone or in addition to
other awards made under the Plan, awards of Shares of the Company's Common Stock
and  other  awards  that  are  valued  in whole  or in part by  reference  to or
otherwise based on Shares of the Company's Common Stock. Other Stock Unit Awards
may  be  paid  in  cash,  in  Shares  of the  Company's  Common  Stock,  or in a
combination  of  cash  and  Shares,  as  determined  by the  Board  in its  sole
discretion.

     (b) The Board shall  determine  the  Participants  to whom other Stock Unit
Awards are to be  granted,  the times at which such  awards are to be made,  the
number of Shares to be granted pursuant to such awards,  and all other terms and
conditions  of such awards.  More than one Stock Unit Award may be granted to an
individual  Participant  under the Plan,  and the terms and  conditions of Stock
Unit Awards granted to the same Participant or to other Participants may differ.
A  Participant  shall not be permitted to sell,  assign,  transfer,  pledge,  or
otherwise  encumber any Shares of Common Stock received pursuant to a Stock Unit



<PAGE>

Award prior to the later of the date on which the Shares are issued, or the date
on which any applicable  restriction,  performance or deferral period determined
by the Board  lapses.  A  Participant  to whom an award of Shares  has been made
pursuant   to  a  Stock  Unit  Award  shall  not  be  required  to  provide  any
consideration  for the  Shares,  other than the  rendering  of  services  or the
payment of any minimum  amount  required by  applicable  law,  unless  otherwise
determined by the Board,

(12)    DEFERRALS OF AWARDS

        The Board may permit  Participants  to defer the  distribution of all or
any part of any award  made  under the Plan in  accordance  with such  terms and
conditions as the Board shall establish.

(13)    RESTRICTIONS ON TRANSFER OF SHARES

     (a)  Notwithstanding  anything to the contrary  contained in the Plan,  the
Company shall not be obligated to issue Plan Shares to a Participant pursuant to
any  option,  award or other  grant  under the Plan,  unless at the time of such
issuance, the Participant agrees not to sell, assign, give, encumber,  pledge or
otherwise  transfer  legal  or  beneficial  ownership  of all or any of the Plan
Shares  to any  person,  corporation  or  other  entity,  during  life  (whether
voluntarily  or  by  involuntary   legal  action),   or  at  death  (whether  by
testamentary  disposition,  intestate  succession or contractual  survivorship),
except as provided in this Paragraph (13). The  Participant's  acceptance of any
Plan Shares shall be deemed to constitute the Participant's  agreement to comply
with the terms and  conditions of this  Paragraph  (13). Any attempt to transfer
any interest in Plan Shares in violation of the  restrictions  contained in this
Paragraph  (13),  or in violation of the transfer  restrictions  and  procedures
contained  elsewhere in this  Agreement,  shall be ineffective and void, and the
Company shall refuse to register the Shares in the name of the transferee.


<PAGE>


     (b) If a Participant  should  receive a bona fide offer for the purchase of
any Plan Shares or should  otherwise  desire to voluntarily sell or transfer any
Plan Shares,  the Participant  shall first give written notice to the Company of
his or her  receipt  of the bona fide  offer or of his or her  desire to sell or
transfer  the Plan  Shares.  The  written  notice  shall  describe  the offer or
proposed sale,  including the name and address of the proposed  transferee,  the
number of Plan  Shares to be  transferred,  the  price per  Share,  the terms of
payment and all other  material terms of the proposed  transaction.  The Company
shall have the first right, but not the obligation, to purchase the Participants
Plan Shares for the lesser of: (i) the price per Share being offered by the bona
fide offeror as described in the Participant's written notice to the Company; or
(ii) the amount  determined  under the Fair Market Value formula price described
in Paragraph  (2)(e) hereof.  

     The Company  shall  exercise its option by sending a written  notice to the
Participant  within  30 days  of the  date of the  Participant's  notice  to the
Company.  If the Company  exercises  its option  within such  30-day  period,  a
closing shall be held at the  Company's  principal  place of business  within 30
days thereafter on a mutually agreed-upon date and time. The Company may pay the
purchase price for the Plan Shares,  as determined above, to the Participant (i)
in full in cash at the Closing, or (ii) at the election of the Company, in equal
monthly,  quarterly  or annual  installments  over a period not to exceed  three
years from the date of Closing.  If the Company elects to pay the purchase price
in installments, the Company shall deliver a promissory note (the "Note") to the
Participant at the Closing  reflecting the payment terms and bearing interest on
the unpaid  balance  thereof at the "Prime  Rate," plus two  percent  (2.0%) per
annum.  Interest  shall be  payable  on the same  dates as the  installments  of
principal.  The  "Prime  Rate"  shall  mean  the  prime  rate  announced  by the
______________  Bank,  Cincinnati,  Ohio on the Closing date.  The Note shall be
unsecured,  The Note may be  prepaid  by the  Company in whole or in part at any
time without penalty.



<PAGE>



     If the Company  fails to exercise  its option to purchase  the Plan Shares,
the Plan  Shares or any  number  of them may be sold at any time  within 90 days
from the date of the Participant's  original notice to the Company, but only for
the price and on the terms  specified  in the  original  notice.  No sale of the
Participants Plan Shares shall be made after the end of the 120-day period,  nor
shall any change in the price or terms of sale or transfer be permitted, without
a new notice of intention to transfer in  compliance  with the  requirements  of
this Paragraph (13).

     (c) For a period  of 180  days  after  the  termination  of a  Participants
Company Relationship with the Company, the Company shall have the right, but not
the obligation,  to purchase all of the  Participant's  Plan Shares for the Fair
Market Value formula price described in Paragraph (2)(e) hereof. The Company may
exercise its option by sending a written  notice to the  Participant  within the
180 day period. If the Company exercises its option within the 180 day period, a
closing shall be held at the  Company's  principal  place of business  within 30
days thereafter on a mutually agreed-upon date and time. The Company may pay the
purchase  price for the Plan Shares to the  Participant:  (i) in full in cash at
the Closing, or (ii) at the election of the Company, in installments on the same
terms and conditions as provided in Paragraph (13)(b) hereof.

     (d) All stock  certificates  now or hereafter  issued by the Company to any
Participant  under the Plan shall be subject to the  transfer  restrictions  and
limitations  of this  Paragraph  (13) and shall contain a restrictive  legend to
that effect.

     (e) The restrictions and provisions  contained in this Paragraph (13) shall
terminate  and be of no further  force or effect with  respect to Plan shares on
the  earlier  of: (i) the date the  Company  successfully  completes  an initial
public  offering of its Common Stock  pursuant to the Securities Act of 1933, as
amended, or (ii) the effective date of the Company's  registration of its Common
Stock as a Class under the Securities Exchange Act of 1934, as amended.



<PAGE>


(14)    EFFECT OF PLAN ON EMPLOYMENT STATUS

     The fact that the Participant has been granted an option or award under the
Plan shall not affect the right of the Company to  terminate  the  Participant's
Company  Relationship  at any time,  subject to the  provisions  of any  written
employment   agreement  or  other   agreement   between  the  Company  and  such
Participant.

(15)    AMENDMENT, MODIFICATION OR TERMINATION OF THE PLAN

     The Board of  Directors  may  terminate,  amend or  modify  the Plan in its
discretion, at any time; provided,  however, that no amendment,  modification or
termination  of  the  Plan  shall  affect  any  outstanding  options  or  awards
theretofore  granted  under the Plan in any  manner,  without the consent of the
Participant or his or her  successor-in-interest.  In addition, any amendment or
modification  that would  increase  the number of Shares  reserved  for issuance
under the Plan or change the requirements as to eligibility for participation in
the Plan,  must also be approved  by the holders of a majority of the  Company's
issued and outstanding Shares of Common Stock.

(16)    WITHHOLDING

     Upon the  transfer of Common  Stock as a result of the  exercise of a stock
option,  the payment of a Restricted  Stock  award,  or the payment of any other
award or qrant,  the  Company  shall  have the  right to retain or sell  without
notice,  sufficient  Shares  to cover  the  amount  of any tax  required  by any
governmental  authority  to be  withheld  or  otherwise  deducted  and paid with
respect to such  payment,  remitting any balance to the  Participant;  provided,
however,  that the Participant shall have the option to provide the Company with
the funds,  including  previously  acquired Shares of the Company's Common Stock
(if  acceptable  to the Board in its  discretion),  to enable it to pay any such
tax.


<PAGE>


(17)    SECURITIES LAWS

     Notwithstanding anything to the contrary contained in the Plan, the Company
shall not be  obligated  to issue  Shares of its Common  Stock to a  Participant
pursuant to any option,  award or other grant under the Plan, unless at the time
of such issuance the Shares are registered,  exempt, or the subject matter of an
exempt  transaction  under both federal and applicable state securities laws. if
requested to do so by the Board,  as a condition to the exercise of an option or
the receipt of Shares,  each Participant shall execute a certificate  indicating
that he or she is purchasing  the Common Stock for  investment  and not with any
present intention to sell or distribute the same.

(18)    TERM OF THE PLAN

     The  Plan  shall  become  effective  on the  date  of its  adoption  by the
Company's  shareholders.  The Plan shall terminate ten years after its effective
date, or on such earlier date as may be determined by the Board of Directors. No
option shall be granted or other award made under the Plan  following the Plan's
termination.  The  termination  of the Plan  shall  not  affect  the  rights  of
Participants  under outstanding  options or awards previously  granted under the
Plan, and all of such unexpired  options and awards shall continue in full force
and  effect  after  termination  of the  Plan,  except  as they may  lapse or be
terminated under the terms and conditions of each individual grant or award.



<PAGE>


                                                                    EXHIBIT 4.2












                            KENDLE INTERNATIONAL INC.

                   1997 STOCK OPTION AND STOCK INCENTIVE PLAN

<PAGE>

                            KENDLE INTERNATIONAL INC.

                   1997 STOCK OPTION AND STOCK INCENTIVE PLAN


                                    SECTION 1

                                   OBJECTIVES

        The objectives of this 1997 Stock Option and Stock Incentive Plan are to
enable Kendle  International  Inc. (the  "Company") to compete  successfully  in
retaining and attracting key employees of outstanding  ability, to stimulate the
efforts of such employees  toward the Company's  objectives and to encourage the
identification of their interests with those of the Company's shareholders.


                                    SECTION 2

                                   DEFINITIONS

        For purposes of this Plan, the following  terms shall have the following
meanings:

        2.1 "Advisor" means any person,  not including Eligible  Employees,  who
provides bona fide advisory or  consultation  services to the Company other than
services in connection with the offer or sale of securities in a capital-raising
transaction.

        2.2 "Award" means any form of Stock Option,  Stock  Appreciation  Right,
Restricted Stock Award,  Unrestricted  Stock Award or Performance  Award granted
under this Plan.

        2.3 "Award  Agreement" means a written agreement setting forth the terms
of an Award.

        2.4  "Award  Date" or  "Grant  Date"  means the date  designated  by the
Committee as the date upon which an Award is granted.

        2.5 "Award Period" or "Term" means the period beginning on an Award Date
and ending on the expiration date of such Award.

        2.6    "Board" means the Board of Directors of the Company.

        2.7 "Code"  means the  Internal  Revenue  Code of 1986,  as amended,  or
successor legislation.



<PAGE>


        2.8  "Committee"  means  the  committee   appointed  by  the  Board  and
consisting of three or more Directors. Members of the Committee who grant awards
pursuant to this Plan must qualify as Non-Employee  Directors as defined by Rule
16b-3(b)(3)(i).  To the extent that it is desired  that  compensation  resulting
from an Award be excluded from the deduction limitation of Section 162(m) of the
Code,  all  members of the  Committee  granting  an Award also shall be "outside
directors"  within the meaning of Code  Section  162(m).  To the extent Ohio law
permits, the Committee may be comprised fewer than three directors.

        2.9  "Disability"  means a "permanent and total  disability"  within the
meaning of Section 22(e)(3) of the Code.

        2.10  "Eligible  Employee"  means anyone who  performs  services for the
Company or a  Subsidiary,  including  an officer or director of the Company or a
Subsidiary;  and  is  compensated  on  a  regular  basis  by  the  Company  or a
Subsidiary.  Directors  who are not  full-time  employees  of the  Company  or a
Subsidiary  are not eligible to receive  Awards  under this Plan,  except as set
forth in Subsection 6.4.  Eligibility under this Plan shall be determined by the
Committee.

        2.11 "Fair  Market  Value"  means,  as of any date,  the  average of the
highest and lowest quoted  selling prices of a Share as reported on the National
Market System of The Nasdaq Stock Market (or such other consolidated transaction
reporting  system on which the Shares are  primarily  traded),  or if the Shares
were not traded on such date,  then the next  preceding  day on which the Shares
were traded,  all as reported by such source as the Committee may select. If the
Shares are not traded on a national  securities exchange or other market system,
Fair Market Value shall be set under procedures established by the Committee.

        2.12  "Incentive  Option" means any Stock Option awarded under Section 6
of this Plan intended to be and designated as an "Incentive Stock Option" within
the meaning of Section 422 of the Code or any successor provision.

        2.13 "Non-Employee Director" means any member of the Board who would not
qualify as an Eligible Employee.

        2.14  "Non-Qualified  Option" means any Stock Option  awarded under this
Plan that is not an Incentive Stock Option.

        2.15 "Officer"  means a person who is considered to be an officer of the
Company under Rule 16a-1(f).

        2.16  "Option  Price" or  "Exercise  Price" means the price per share at
which Common Stock may be purchased upon the exercise of an Option or an Award.

        2.17 "Participant" means an Eligible Employee,  Non-Employee Director or
Advisor to whom an Award has been made pursuant to this Plan.



<PAGE>


        2.18  "Restricted  Stock" means Shares  issued  pursuant to a Restricted
Stock Award which are subject to the restrictions set forth in the related Award
Agreement.

        2.19 "Restricted Stock Award" means an award of a fixed number of Shares
to a Participant which is subject to forfeiture  provisions and other conditions
set forth in the Award Agreement.

        2.20 "Retirement"  means any termination of employment or service on the
Board (other than by death or Disability) by an employee or a director who is at
least 65 years of age (or 55 years of age with at least ten years of  employment
with, or service on the Board of, the Company or a Subsidiary).

        2.21   "Rule 16b-3"  and  "Rule 16a-1(f)" mean Securities  and  Exchange
Commission  Regulations  Sect. 240.16b-3  and  Sect.  240.16a-1(f)  or  any
corresponding successor regulations.

        2.22   "Share" means one share of the Company's Common Stock.

        2.23 "Stock Appreciation Right" or "SAR" means the right to receive, for
each unit of the SAR,  cash  and/or  Shares  equal in value to the excess of the
Fair  Market  Value of one  Share on the  date of  exercise  of the SAR over the
reference price per Share established on the date the SAR was granted.

        2.24  "Stock  Option" or  "Option"  means the right to  purchase  Shares
granted pursuant to Section 6 of this Plan.

        2.25 "Subsidiary" means any corporation,  partnership, joint venture, or
other entity (i) of which the Company owns or controls,  directly or indirectly,
25% or more of the outstanding voting stock (or comparable equity  participation
and voting power) or (ii) which the Company  otherwise  controls (by contract or
any other means);  except that when the term "Subsidiary" is used in the context
of an award of an Incentive  Option,  the term shall have the same meaning given
to it in the Code. "Control" means the power to direct or cause the direction of
the management and policies of a corporation or other entity.

        2.26 "Transfer" means alienation,  attachment, sale, assignment, pledge,
encumbrance,  charge  or  other  disposition;  and the  terms  "Transferred"  or
"Transferable" have corresponding meanings.


                                    SECTION 3

                                 ADMINISTRATION

        3.1    This Plan shall be administered and interpreted by the Committee.



<PAGE>


        3.2 The Committee  shall have full  authority to grant,  pursuant to the
terms of this Plan, to Eligible Employees and Advisors:  (i) Stock Options, (ii)
Stock Appreciation  Rights,  (iii) Restricted Stock, (iv) Unrestricted Stock and
(v) Performance Awards. In particular, the Committee shall have the authority:

          (a) to select the Eligible  Employees  and Advisors to whom Awards may
     be granted;

          (b) to determine the types and combinations of Awards to be granted to
     Eligible Employees and Advisors;

          (c) to determine  the number of Shares or monetary  units which may be
     subject to each Award;

          (d) to determine the terms and conditions,  not inconsistent  with the
     terms of this Plan, of any Award (including,  but not limited to, the term,
     price, exercisability, method of exercise, any restriction or limitation on
     transfer,   any  vesting  schedule  or  acceleration,   or  any  forfeiture
     provisions or waiver, regarding any Award) and the related Shares, based on
     such factors as the Committee shall determine; and

          (e) to modify or waive any  restrictions or limitations  contained in,
     and grant  extensions  to the terms of or  accelerate  the vestings of, any
     outstanding Awards as long as such  modifications,  waivers,  extensions or
     accelerations are not inconsistent with the terms of this Plan, but no such
     changes  shall  impair the  rights of any  Participant  without  his or her
     consent.

        3.3 The Committee  shall have the  authority to adopt,  alter and repeal
administrative  rules,  guidelines and practices governing this Plan and perform
all acts, including the delegation of its administrative responsibilities, as it
deems advisable; to construe and interpret the terms and provisions of this Plan
and  any  Award  issued  under  this  Plan;  and  to  otherwise   supervise  the
administration  of this Plan.  The Committee may correct any defect,  supply any
omission or reconcile  any  inconsistency  in this Plan or in any related  Award
Agreement in the manner and to the extent it deems  necessary to carry this Plan
into effect.

        3.4 Any action,  decision,  interpretation or determination by or at the
direction of the Committee  concerning the application or administration of this
Plan shall be final and binding  upon all  persons and need not be uniform  with
respect to its  determination  of recipients,  amount,  timing,  form,  terms or
provisions of Awards.


                                    SECTION 4

                             SHARES SUBJECT TO PLAN

        4.1 Shares.  Subject to adjustment  as provided in  Subsection  4.2, the
aggregate  number of Shares which may be issued under this Plan shall not exceed
One Million (1,000,000) Shares.


<PAGE>

     If any Award granted under this Plan shall expire, terminate or be canceled
for any reason  without  having been exercised in full, the number of unacquired
Shares  subject to such Award shall again be available  for future  grants.  The
Committee  may make such other  determinations  regarding the counting of Shares
issued pursuant to this Plan as it deems  necessary or advisable,  provided that
such determinations shall be permitted by law.

        4.2    Adjustment Provisions.

        (a) If the Company  shall at any time change the number of issued Shares
without new  consideration  to the  Company  (such as by stock  dividend,  stock
split,  recapitalization,   reorganization,  exchange  of  shares,  liquidation,
combination or other change in corporate structure affecting the Shares) or make
a distribution  of cash or property which has a substantial  impact on the value
of issued  Shares,  the total number of Shares  reserved for issuance  under the
Plan shall be  appropriately  adjusted and the number of Shares  covered by each
outstanding  Award  and the  reference  price  or Fair  Market  Value  for  each
outstanding Award shall be adjusted so that the aggregate  consideration payable
to the Company and the value of each such Award shall not be changed.

        (b)  Notwithstanding  any  other  provision  of the  Plan,  and  without
affecting the number of Shares  reserved or available  hereunder,  the Committee
may authorize the issuance,  continuation or assumption of Awards or provide for
other  equitable  adjustments  after  changes in the Shares  resulting  from any
merger,  consolidation,  sale of  assets,  acquisition  of  property  or  stock,
recapitalization,  reorganization or similar  occurrence in which the Company is
the  continuing or surviving  corporation,  upon such terms and conditions as it
may deem equitable and appropriate.

        4.3  Dissolution  or  Liquidation.  In the event of the  dissolution  or
liquidation of the Company or any merger,  consolidation or combination in which
the Company is not the surviving  corporation or in which the outstanding Shares
of the Company are converted into cash, other securities or other property, each
outstanding Award shall terminate as of a date fixed by the Committee,  provided
that not less than 20 days' written  notice of the date of  expiration  shall be
given to each  holder  of an Award  and each such  holder  shall  have the right
during  such  period  following  notice to  exercise  the Award as to all of the
shares covered by the option.


                                    SECTION 5

                                DURATION OF PLAN

        This Plan  shall  continue  in effect  until  August  __,  2007,  unless
terminated sooner by the Board pursuant to Section 12.




<PAGE>


                                    SECTION 6

                                  STOCK OPTIONS

        6.1 Grants.  Stock  options may be granted alone or in addition to other
Awards  granted  under this Plan.  Each Option  granted  shall be  designated as
either a  Non-Qualified  Option  or an  Incentive  Option  and in each case such
Option  may or may not  include  Stock  Appreciation  Rights.  One or more Stock
Options and/or Stock Appreciation Rights may be granted to any Eligible Employee
or Advisor, except that only Non-Qualified Options may be granted to Advisors.

        6.2  Incentive  Options.  Any option  designated  by the Committee as an
Incentive Stock Option will be subject to the general  provisions  applicable to
all Options granted under the Plan plus the following specific provisions:

               (a) If an Incentive Stock Option is granted to a person who owns,
        directly  or  indirectly,  stock  representing  more than 10% of (i) the
        total combined  voting power of all classes of stock of the Company,  or
        (ii) a corporation  that owns 50% or more of the total  combined  voting
        power of all classes of stock of the Company,

                    (i) The  Option  Price  must equal at least 110% of the Fair
               Market Value on the date of grant; and

                    (ii) The term of the Option  shall not be greater  than five
               years from the date of grant.

               (b) The aggregate Fair Market Value of Shares,  determined at the
        date of grant, with respect to which Incentive Stock Options that may be
        exercised for the first time during any calendar year under this Plan or
        any other plan maintained by the Company shall not exceed $100,000.

               (c)  Qualification  under the Code.  Notwithstanding  anything in
        this Plan to the  contrary,  no term of this Plan  relating to Incentive
        Options  shall  be  interpreted,  amended  or  altered,  nor  shall  any
        discretion or authority  granted under this Plan be exercised,  so as to
        disqualify  this Plan under  Section  422 of the Code,  or,  without the
        consent of the Participants affected, to disqualify any Incentive Option
        under Section 422 of the Code.

        6.3 Terms of Options.  Except as otherwise  required by Subsections  6.2
and 6.4, Options granted under this Plan shall be subject to the following terms
and conditions and shall be in such form and contain such  additional  terms and
conditions, not inconsistent with the terms of this Plan, as the Committee shall
deem desirable:

               (a)  Option  Price.  The Option  Price per share of Common  Stock
        purchasable under a Stock Option shall be determined by the Committee at
        the time of grant, except that no Incentive Option may be granted for an
        Option Price less than 100% of  Fair  Market Value on the Grant Date and
        no Non-Qualified Stock Option  may  be granted for an Option  Price less
        than 95% of the Fair Market  Value on the Date of Grant.

<PAGE>


               (b)    Option Term.  The Term of each Stock Option shall be fixed
        by the Committee, but no Option shall be exercisable more than ten years
        after its Award Date.

               (c)  Exercisability.  A Stock Option shall be exercisable at such
        time or times  and  subject  to such  terms and  conditions  as shall be
        specified in the Award Agreement.

               (d) Method of Exercise.  Stock  Options may be exercised in whole
        or in part at any time during the Option Term by giving  written  notice
        of  exercise  to the  Company  specifying  the  number  of  Shares to be
        purchased.  Such notice shall be  accompanied  by payment in full of the
        Option Price in cash unless some other form of consideration is approved
        by the Committee at or after the grant. If and to the extent  determined
        by the Committee at or after grant,  payment in full or in part may also
        be made in the form of  Common  Stock  owned by the  Participant  for at
        least six months  prior to  exercise  or by  reduction  in the number of
        Shares  issuable upon exercise  based,  in each case, on the Fair Market
        Value of the Common Stock on the payment date.

               (e)   Transferability   of  Options.   Stock   Options  shall  be
        Transferable as provided in Section 10 of this Plan.

        6.4    Award of Options to Non-Employee Directors.

               (a) Grants.  The  Company  shall make the  following  immediately
        exercisable  grants  of  Non-Qualified  Stock  Options  to  Non-Employee
        Directors under this Plan:

                      (i) On the  date on  which  the  Company  consummates  its
               initial public  offering of Common Stock as registered  under the
               Securities Act of 1933, an Option for Ten Thousand Shares.

                      (ii)  On the  date on  which  a  person  first  becomes  a
               Non-Employee  Director,  whether by election or  appointment,  an
               Option for Five Thousand Shares.

                      (iii) An Option for Five Thousand  Shares upon election as
               a director at the first Annual  Shareholders'  Meeting held after
               the Company's initial public offering and

                      (iv) An Option for One  Thousand  Shares  upon each annual
               election as a director thereafter.



<PAGE>


               (b) Terms and  Conditions  of  Options  Granted  to  Non-Employee
          Directors.

                    (i) Term. The Term of all Options shall be 10 years from the
               Award Date of the Option.

                    (ii) Option Price.  The Option Price of all Options shall be
               the Fair Market Value of a Share on the Grant Date.

                    (iii) Transferability and Termination.  All Options shall be
               Transferable  as  provided  in  Section 10 of this Plan and shall
               terminate in accordance with Section 11 of this Plan, except that
               the timing  provisions  of  Subsections  11.2 and 11.3 may not be
               varied by Committee determination.


                                    SECTION 7

                            STOCK APPRECIATION RIGHTS

        7.1 Grant.  A Stock  Appreciation  Right may be granted  either  with or
without  reference to all or any part of a Stock Option. A "Tandem SAR" means an
SAR granted  with  reference  to a Stock  Option  (the  "Reference  Option").  A
"Non-Tandem  SAR" means an SAR granted without  reference to a Stock Option.  If
the Reference  Option is a Non-Qualified  Option, a Tandem SAR may be granted at
or  after  the date of the  Reference  Option;  if the  Reference  Option  is an
Incentive  Option,  the Grant Date of a Tandem SAR must be the same as the Grant
Date of the Reference Option. Any SAR shall have such terms and conditions,  not
inconsistent  with this Plan, as are  established by the Committee in connection
with the Award.

        7.2 Term. A Tandem SAR shall terminate and no longer be exercisable upon
the  termination  of its Reference  Option.  A Non-Tandem SAR may have a term no
longer than 10 years from its Grant Date.

        7.3 Exercise.  A Tandem SAR may only be exercisable at the times and, in
whole or in part, to the extent that its Reference  Option is  exercisable.  The
exercise  of a Tandem SAR shall  automatically  result in the  surrender  of the
applicable  portion  of  its  Reference  Option.  A Non-  Tandem  SAR  shall  be
exercisable  in whole or in part as  provided  in its Award  Agreement.  Written
notice of any exercise must be given in the form prescribed by the Committee.

        7.4 Payment.  For purposes of payment of an SAR, the reference price per
Share shall be the Option Price of the Reference  Option in the case of a Tandem
SAR and shall be the Fair Market  Value of a Share on the Grant Date in the case
of a Non-Tandem SAR. The Committee shall determine the form of payment.



<PAGE>

        7.5 Transferability and Termination.  Stock Appreciation Rights shall be
Transferable  as provided in Section  11.1 of this Plan and shall  terminate  in
accordance with Section 11 of this Plan.


                                    SECTION 8

                    RESTRICTED AND UNRESTRICTED STOCK AWARDS

        8.1  Grants of  Restricted  Stock  Awards.  The  Committee  may,  in its
discretion,  grant one or more Restricted Stock Awards to any Eligible  Employee
or Advisor. Each Restricted Stock Award shall specify the number of Shares to be
issued to the Participant,  the date of such issuance,  the price, if any, to be
paid for such Shares by the  Participant  and the  restrictions  imposed on such
Shares.  The  Committee  may grant  Awards of  Restricted  Stock  subject to the
attainment of specified  performance goals,  continued  employment or such other
limitations or restrictions as the Committee may determine.

        8.2  Terms and Conditions of Restricted Awards.  Restricted Stock Awards
shall be subject to the following provisions:

          (a)  Issuance  of  Shares.  Shares of  Restricted  Stock may be issued
     immediately upon grant or upon vesting as determined by the Committee.

          (b) Stock Powers and Custody. If Shares of Restricted Stock are issued
     immediately  upon grant,  the  Committee  may require  the  Participant  to
     deliver a duly  signed  stock  power,  endorsed  in blank,  relating to the
     Restricted  Stock covered by such an Award.  The Committee may also require
     that the stock  certificates  evidencing  such shares be held in custody by
     the Company until the restrictions on them shall have lapsed.

          (c) Shareholder Rights.  Unless otherwise  determined by the Committee
     at the time of grant,  Participants receiving Restricted Stock Awards shall
     not be  entitled to dividend  or voting  rights for the  Restricted  Shares
     until they are fully vested.

        8.3  Unrestricted  Stock  Awards.  The  Committee  may  make  awards  of
unrestricted  Common Stock to key Eligible Employees and Advisors in recognition
of outstanding  achievements  or  contributions  by such employees and advisors.
Unrestricted  Shares  issued on a bonus basis under this  Subsection  8.3 may be
issued for no cash consideration. Each certificate for unrestricted Common Stock
shall be registered in the name of the Participant and delivered  immediately to
the Participant.




<PAGE>


                                    SECTION 9

                               PERFORMANCE AWARDS

        9.1    Performance Awards.

               (a)  Grant.   The  Committee  may,  in  its   discretion,   grant
        Performance  Awards to Eligible  Employees and  Advisors.  A Performance
        Award shall  consist of the right to receive  either (i) Common Stock or
        cash of an equivalent  value,  or a combination of both, at the end of a
        specified  Performance  Period  (defined  below) or (ii) a fixed  dollar
        amount  payable in cash or Shares,  or a combination of both, at the end
        of a specified  Performance  Period.  The Committee  shall determine the
        Eligible  Employees  and Advisors to whom and the time or times at which
        Performance Awards shall be granted,  the number of Shares or the amount
        of cash to be awarded to any  person,  the  duration  of the period (the
        "Performance  Period") during which,  and the conditions  under which, a
        Participant's  Performance  Award  will  vest,  and the other  terms and
        conditions  of the  Performance  Award in addition to those set forth in
        Subsection 9.2.

               (b) Criteria for Award.  The Committee may condition the grant or
        vesting  of  a  Performance  Award  upon  the  attainment  of  specified
        performance goals; the appreciation in the Fair Market Value, book value
        or other measure of value of the Common Stock;  the  performance  of the
        Company  based on  earnings  or cash  flow;  or such  other  factors  or
        criteria as the Committee shall determine.

        9.2    Terms and Conditions of Performance  Awards.   Performance Awards
granted pursuant to  this Section 9  shall be subject to the following terms and
 conditions:

               (a) Dividends.  Unless  otherwise  determined by the Committee at
        the  time of the  grant of the  Award,  amounts  equal to any  dividends
        declared  during  the  Performance  Period  with  respect  to any Shares
        covered by a Performance Award will not be paid to the Participant.

               (b) Payment. Subject to the provisions of the Award Agreement and
        this  Plan,  at  the  expiration  of  the  Performance   Period,   share
        certificates,  cash or both (as the  Committee may  determine)  shall be
        delivered  to the  Participant,  or his or her legal  representative  or
        guardian,  in a number or an amount  equal to the vested  portion of the
        Performance Award.

               (c)    Transferability.  Performance Awards shall be Transferable
        as provided in Section 10 of this Plan.

               (d)   Termination of Employment or Advisory Relationship. Subject
        to the applicable provisions of the Award  Agreement and this Plan, upon

<PAGE>


        termination  of a  Participant's  employment or  advisory  relationship
        with the  Company or a Subsidiary for any reason during the  Performance
        Period for  a given Award, the Performance  Award in question  will vest
        or  be  forfeited  in  accordance   with   the  terms  and    conditions
        established by the Committee.


                                   SECTION 10

                            TRANSFERABILITY OF AWARDS

        No Award or benefit payable under this Plan shall be Transferable by the
Participant  during  his or her  lifetime  and may not be  assigned,  exchanged,
pledged, transferred or otherwise encumbered or disposed of except by a domestic
relations order pursuant to Section  414(p)(1)(B) of the Code, or by will or the
laws  of  descent  and  distribution.  Awards  shall  be  exercisable  during  a
Participant's  lifetime only by the Participant or by the Participant's guardian
or legal representative.


                                   SECTION 11

                                   TERMINATION

        11.1 Termination at Expiration of Term.  During any period of continuous
employment or business  relationship with the Company or a Subsidiary,  an Award
will be  terminated  only if it is fully  exercised  or if it has expired by its
terms.  For purposes of this Plan, any leave of absence  approved by the Company
shall not be deemed to be a termination of employment.

        11.2 Termination by Death, Disability or Retirement.  If a Participant's
employment  by the  Company  or a  Subsidiary  terminates  by  reason  of death,
Disability or Retirement,  or in the case of an advisory  relationship,  if such
business  relationship  terminates by reason of death or  Disability,  any Award
held by such Participant, unless otherwise determined by the Committee at grant,
shall be fully vested and may  thereafter be exercised by the  Participant or by
the Participant's beneficiary or legal representative,  for a period of one year
following  termination of employment (or such longer period as the Committee may
specify at or after  grant in all cases other than  Incentive  Options) or until
the expiration of the stated term of such Award, whichever period is shorter.

        11.3 Other Termination.  Unless otherwise determined by the Committee at
or after grant, if a Participant's employment by, or business relationship with,
the  Company  or a  Subsidiary  terminates  for any  reason  other  than  death,
Disability or  Retirement,  the Award will  terminate on the earlier to occur of
the  stated  expiration  date  or 90  calendar  days  after  termination  of the
employment or business  relationship.  If a  Participant  dies during the 90 day
period following the termination of the employment or business relationship, any
unexercised  Award held by the Participant (or transferred by the Participant in
accordance  with  Section 10 of this  Plan)  shall be  exercisable,  to the full
extent  that  such  Award  was exercisable at the time of death, for a period of
90  calendar  days  from  the  date of death  of the  Participant  or until  the
expiration of the stated term of the Award, whichever occurs first.

<PAGE>



                                   SECTION 12

                      TERMINATION OR AMENDMENT OF THIS PLAN

        12.1  Termination  or Amendment.  The Board may at any time,  amend,  in
whole or in part,  any or all of the  provisions  of this  Plan,  or  suspend or
terminate it entirely;  provided,  however,  that, unless otherwise  required by
law, the rights of a  Participant  with respect to any Awards  granted  prior to
such  amendment,  suspension  or  termination  may not be  impaired  without the
consent of such Participant;  and,  provided  further,  no amendment which would
increase  the number of shares  available  under  this Plan may be made  without
shareholder approval.


                                   SECTION 13

                               GENERAL PROVISIONS

        13.1 No Right to Continued Employment or Business Relationship.  Neither
the  establishment  of the Plan nor the  granting of any Award  hereunder  shall
confer  upon any  Participant  any right to continue in the employ of, or in any
business  relationship with, the Company or any Subsidiary,  or interfere in any
way with the right of the Company or any Subsidiary to terminate such employment
or business relationship at any time.

        13.2  Other  Plans.  In no event  shall the value of, or income  arising
from, any Awards issued under this Plan be treated as compensation  for purposes
of any pension,  profit sharing, life insurance,  disability or other retirement
or welfare  benefit plan now  maintained or hereafter  adopted by the Company or
any Subsidiary, unless such plan specifically provides to the contrary.

        13.3  Withholding  of Taxes.  The Company shall have the right to deduct
from any payment to be made  pursuant  to this Plan,  or to  otherwise  require,
prior to the  issuance or delivery of any Shares or the payment of any cash to a
Participant,  payment by the Participant of any Federal, state, local or foreign
taxes  required  by law to be  withheld.  The  Committee  may  permit  any  such
withholding  obligation  to be  satisfied  by  reducing  the  number  of  Shares
otherwise  deliverable or by accepting the delivery of previously  owned Shares.
Any  fraction  of a Share  required  to satisfy  such tax  obligations  shall be
disregarded and the amount due shall be paid instead in cash by the Participant.

        13.4 Reimbursement of Taxes. The Committee may provide in its discretion
that the Company may  reimburse a  Participant  for  federal,  state,  local and
foreign  tax  obligations  incurred  as a result of the grant or  exercise of an
Award issued under this Plan.



<PAGE>


        13.5   Governing Law.  This Plan and actions taken in connection with it
shall be governed by the laws  of  the  State  of  Ohio,  without  regard to the
principles of conflict of laws.

        13.6  Liability.  No employee of the Company nor member of the Committee
or the Board  shall be liable for any action or  determination  taken or made in
good faith with respect to the Plan or any Award granted  hereunder  and, to the
fullest extent  permitted by law, all employees and members shall be indemnified
by the Company for any liability and expenses  which may occur through any claim
or cause of action  arising under or in connection  with this Plan or any Awards
granted under this Plan.





                                    EXHIBIT 5

                     OPINION OF KEATING, MUETHING & KLEKAMP



                            FACSIMILE (513) 579-6956



                                 August 22, 1997

Direct D(513) 579-6411
E-Mail:  gkreideKMKlaw.com



Ladies and Gentlemen:

     This firm is general counsel to Kendle  International  Inc.(the  "Company")
and as such, we are familiar with the Company's Articles of Incorporation,  Code
of  Regulations  and  corporate  proceedings  generally.  We have  reviewed  the
corporate  records as to the  establishment of the Company's 1995 and 1997 Stock
Option  Plans which call for the issuance of shares of Common Stock to employees
of the Company and its  subsidiaries  upon exercise of options  granted to them.
Based solely upon such examination, we are of the opinion that:

     1. The Company is a duly organized and validly existing  corporation  under
the laws of the State of Ohio; and

     2. The Company has taken all  necessary and required  corporate  actions in
connection  with the  proposed  issuance  of  1,743,907  shares of Common  Stock
pursuant to the 1995 and 1997 Stock Option Plans,  and such Common  Stock,  when
issued and  delivered,  will be validly  issued,  fully paid and  non-assessable
shares of Common Stock of the Company free of any claim of pre-emptive rights.

     We  hereby  consent  to be  named  in the  Registration  Statement  and the
Prospectus  part thereof as the  attorneys who have passed upon legal matters in
connection with the issuance of the aforesaid  Common Stock and to the filing of
this opinion as an exhibit to the Registration Statement.

                                          Yours truly,

                                          KEATING, MUETHING & KLEKAMP, P.L.L.


                                          BY:  /S/Edward E. Steiner
                                             --------------------------------
                                                  Edward E. Steiner






                                  EXHIBIT 23.1


                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

We consent to the incorporation by reference in this  registration  statement on
Form S-8 to be filed on August  22,  1997 of our  report  dated  March 21,  1997
except as to the information presented in Notes 10 and 11, for which the date is
August 20,  1997,  on our audits of the  consolidated  financial  statements  of
Kendle  International  Inc. as of December 31, 1995 and 1996,  and for the three
years in the period  ended  December 31,  1996,  appearing  in the  registration
statement on Form S-1 (File No.  333-30581) of Kendle  International  Inc. filed
with the  Securities and Exchange  Commission  pursuant to the Securities Act of
1933.

/s/Coopers & Lybrand L.L.P.

Cincinnati, Ohio
August 20, 1997




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